SLC16A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)8.52178637
2* urate metabolic process (GO:0046415)7.82587653
3aminoglycoside antibiotic metabolic process (GO:0030647)7.37919634
4drug transport (GO:0015893)7.07466283
5organic cation transport (GO:0015695)6.78222133
6lysine metabolic process (GO:0006553)6.68826129
7lysine catabolic process (GO:0006554)6.68826129
8phosphate ion transport (GO:0006817)6.45311138
9glucocorticoid biosynthetic process (GO:0006704)6.41865560
10drug catabolic process (GO:0042737)5.91483975
11exogenous drug catabolic process (GO:0042738)5.67848741
12phosphate ion transmembrane transport (GO:0035435)5.53567828
13quaternary ammonium group transport (GO:0015697)5.43953771
14surfactant homeostasis (GO:0043129)5.39520502
15response to mercury ion (GO:0046689)5.28442063
16tricarboxylic acid metabolic process (GO:0072350)5.16511412
17presynaptic membrane assembly (GO:0097105)5.15788929
18cysteine metabolic process (GO:0006534)5.05744055
19renal absorption (GO:0070293)4.94212887
20glyoxylate metabolic process (GO:0046487)4.76410290
21excretion (GO:0007588)4.75091461
22toxin transport (GO:1901998)4.69278683
23peptide catabolic process (GO:0043171)4.65776700
24nonribosomal peptide biosynthetic process (GO:0019184)4.57889855
25pyrimidine nucleobase catabolic process (GO:0006208)4.55211694
26vitamin D metabolic process (GO:0042359)4.54316249
27phosphate ion homeostasis (GO:0055062)4.54199529
28trivalent inorganic anion homeostasis (GO:0072506)4.54199529
29metanephric tubule development (GO:0072170)4.52390690
30metanephric nephron tubule development (GO:0072234)4.52390690
31presynaptic membrane organization (GO:0097090)4.44005148
32valine metabolic process (GO:0006573)4.42287953
33branched-chain amino acid metabolic process (GO:0009081)4.41404821
34metanephric nephron epithelium development (GO:0072243)4.31934851
35glucocorticoid metabolic process (GO:0008211)4.29959132
36short-chain fatty acid metabolic process (GO:0046459)4.29718463
37aspartate family amino acid catabolic process (GO:0009068)4.20585980
38glutathione biosynthetic process (GO:0006750)4.18825362
39homocysteine metabolic process (GO:0050667)4.17494347
40chemical homeostasis within a tissue (GO:0048875)4.08636736
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.07457007
42carnitine transport (GO:0015879)4.04311002
43amino-acid betaine transport (GO:0015838)4.04311002
44metanephric epithelium development (GO:0072207)4.00523782
45cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.97927816
46fatty acid beta-oxidation (GO:0006635)3.91361788
47glycoside metabolic process (GO:0016137)3.86094237
48estrogen biosynthetic process (GO:0006703)3.83772438
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.79448793
50L-phenylalanine metabolic process (GO:0006558)3.79448793
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.72972723
52L-phenylalanine catabolic process (GO:0006559)3.72972723
532-oxoglutarate metabolic process (GO:0006103)3.70851041
54nucleobase catabolic process (GO:0046113)3.68419583
55fatty acid oxidation (GO:0019395)3.68055755
56branched-chain amino acid catabolic process (GO:0009083)3.67099032
57sodium-independent organic anion transport (GO:0043252)3.65996276
58modified amino acid transport (GO:0072337)3.61943919
59lipid oxidation (GO:0034440)3.61446197
60androgen biosynthetic process (GO:0006702)3.61158362
61aromatic amino acid family catabolic process (GO:0009074)3.59803236
62cellular modified amino acid catabolic process (GO:0042219)3.55729404
63C21-steroid hormone biosynthetic process (GO:0006700)3.50518700
64nephron tubule development (GO:0072080)3.48126737
65indole-containing compound catabolic process (GO:0042436)3.45516139
66indolalkylamine catabolic process (GO:0046218)3.45516139
67tryptophan catabolic process (GO:0006569)3.45516139
68proline metabolic process (GO:0006560)3.45082040
69amino-acid betaine metabolic process (GO:0006577)3.44255096
70peptide biosynthetic process (GO:0043043)3.42386358
71tryptophan metabolic process (GO:0006568)3.37539826
72response to growth hormone (GO:0060416)3.37451915
73vitamin transport (GO:0051180)3.36984641
74neuron cell-cell adhesion (GO:0007158)3.34728766
75drug metabolic process (GO:0017144)3.34453446
76response to phenylpropanoid (GO:0080184)3.34130168
77postsynaptic membrane organization (GO:0001941)3.28001519
78response to follicle-stimulating hormone (GO:0032354)3.27119427
79fatty acid catabolic process (GO:0009062)3.26254859
80fructose metabolic process (GO:0006000)3.20424395
81serine family amino acid catabolic process (GO:0009071)3.20087053
82carnitine metabolic process (GO:0009437)3.19741353
83nonmotile primary cilium assembly (GO:0035058)3.16972016
84intraciliary transport (GO:0042073)3.14370146
85regulation of development, heterochronic (GO:0040034)3.12558062
86renal tubule development (GO:0061326)3.11386457
87cellular ketone body metabolic process (GO:0046950)3.09441624
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07498747
89cellular response to vitamin D (GO:0071305)3.06648704
90hormone catabolic process (GO:0042447)3.05562817
91epithelial cilium movement (GO:0003351)3.02127023
92Leydig cell differentiation (GO:0033327)3.00813127
93nephron epithelium development (GO:0072009)2.93967522
94acetyl-CoA metabolic process (GO:0006084)2.93867561
95protein localization to cilium (GO:0061512)2.92996917
96glutathione metabolic process (GO:0006749)2.92518391
97sulfur amino acid catabolic process (GO:0000098)2.92429448
98monocarboxylic acid catabolic process (GO:0072329)2.92241420
99cellular response to gonadotropin stimulus (GO:0071371)2.92027666
100NADH metabolic process (GO:0006734)2.92000669
101L-ascorbic acid metabolic process (GO:0019852)2.91677174
102biotin metabolic process (GO:0006768)2.90795228
103retinal ganglion cell axon guidance (GO:0031290)2.90422757
104neuronal stem cell maintenance (GO:0097150)2.89518401
105toxin metabolic process (GO:0009404)2.89460890
106serine family amino acid metabolic process (GO:0009069)2.87898674
107cellular amino acid catabolic process (GO:0009063)2.87821924
108response to parathyroid hormone (GO:0071107)2.86998683
109glutamate metabolic process (GO:0006536)2.86660245
110polyol transport (GO:0015791)2.84256287
111neuron fate determination (GO:0048664)2.81313048
112oligosaccharide catabolic process (GO:0009313)2.80592332
113regulation of timing of cell differentiation (GO:0048505)2.79999689
114water-soluble vitamin biosynthetic process (GO:0042364)2.77467994
115cilium movement (GO:0003341)2.76488387
116organic acid catabolic process (GO:0016054)2.76443907
117carboxylic acid catabolic process (GO:0046395)2.76443907
118sulfur compound transport (GO:0072348)2.76002324
119regulation of hexokinase activity (GO:1903299)2.74806234
120regulation of glucokinase activity (GO:0033131)2.74806234
121beta-amyloid metabolic process (GO:0050435)2.74484839
122hormone biosynthetic process (GO:0042446)2.74430043
123response to insecticide (GO:0017085)2.73549150
124growth hormone receptor signaling pathway (GO:0060396)2.72693630
125axonal fasciculation (GO:0007413)2.72685112
126alpha-amino acid catabolic process (GO:1901606)2.72177845
127benzene-containing compound metabolic process (GO:0042537)2.71618098
128flavonoid metabolic process (GO:0009812)2.71083493
129dendritic spine morphogenesis (GO:0060997)2.70588785
130aromatic amino acid family metabolic process (GO:0009072)2.70141721
131ketone body metabolic process (GO:1902224)2.69478758
132hippocampus development (GO:0021766)2.68905617
133glutathione derivative biosynthetic process (GO:1901687)2.67807188
134glutathione derivative metabolic process (GO:1901685)2.67807188
135positive regulation of amino acid transport (GO:0051957)2.67245624
136negative regulation of oligodendrocyte differentiation (GO:0048715)2.65902703
137calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.65666604
138regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57385450
139negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55371494
140neuron recognition (GO:0008038)2.53345890
141regulation of cilium movement (GO:0003352)2.53163764
142positive regulation of hormone biosynthetic process (GO:0046886)2.52131415
143vocalization behavior (GO:0071625)2.49776090
144limb bud formation (GO:0060174)2.49306254
145cilium assembly (GO:0042384)2.48503819
146cilium organization (GO:0044782)2.47915865
147cilium morphogenesis (GO:0060271)2.47393706
148synapse assembly (GO:0007416)2.47003705
149kidney morphogenesis (GO:0060993)2.42310357
150neurotransmitter-gated ion channel clustering (GO:0072578)2.40327601
151regulation of male gonad development (GO:2000018)2.38271421
152lactate metabolic process (GO:0006089)2.37968491
153hindbrain development (GO:0030902)2.37683837
154aggressive behavior (GO:0002118)2.37624200
155cellular response to cholesterol (GO:0071397)2.32603514
156regulation of oligodendrocyte differentiation (GO:0048713)2.32226010
157olfactory bulb development (GO:0021772)2.30892136
158lung-associated mesenchyme development (GO:0060484)2.29903914
159regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.29825943
160atrial cardiac muscle cell action potential (GO:0086014)2.28242087
161brain morphogenesis (GO:0048854)2.27958629
162cochlea development (GO:0090102)2.26927502
163protein polyglutamylation (GO:0018095)2.26718770
164forebrain neuron differentiation (GO:0021879)2.26008926
165appendage development (GO:0048736)2.25825354
166limb development (GO:0060173)2.25825354
167axoneme assembly (GO:0035082)2.25569411
168response to leptin (GO:0044321)2.24443298
169C21-steroid hormone metabolic process (GO:0008207)2.24056212
170smoothened signaling pathway (GO:0007224)2.23945631
171somite development (GO:0061053)2.23521760
172axonemal dynein complex assembly (GO:0070286)2.21500213
173negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.21462785
174negative regulation of translation, ncRNA-mediated (GO:0040033)2.21462785
175regulation of translation, ncRNA-mediated (GO:0045974)2.21462785
176cell proliferation in forebrain (GO:0021846)2.21384095
177lateral sprouting from an epithelium (GO:0060601)2.19330489
178positive regulation of synapse assembly (GO:0051965)2.18970536
179nephron tubule morphogenesis (GO:0072078)2.18507649
180nephron epithelium morphogenesis (GO:0072088)2.18507649
181negative regulation of glial cell differentiation (GO:0045686)2.16678511
182cellular response to sterol (GO:0036315)2.16335383
183sequestering of actin monomers (GO:0042989)2.16292451
184mechanosensory behavior (GO:0007638)2.15043336
185regulation of feeding behavior (GO:0060259)2.14524191
186regulation of non-canonical Wnt signaling pathway (GO:2000050)2.13956080
187prostate gland growth (GO:0060736)2.13417319
188DNA double-strand break processing (GO:0000729)2.13045164
189cellular response to antibiotic (GO:0071236)2.11931045
190positive regulation of oligodendrocyte differentiation (GO:0048714)2.10784782
191transmission of nerve impulse (GO:0019226)2.10604290
192establishment of nucleus localization (GO:0040023)2.10383103
193behavioral response to nicotine (GO:0035095)2.10139867
194cranial nerve development (GO:0021545)2.09508725
195photoreceptor cell maintenance (GO:0045494)2.09146343
196startle response (GO:0001964)2.08576368
197pituitary gland development (GO:0021983)2.08239168
198membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.07647698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.36419123
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.74684113
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.38508913
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.14632096
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.02568960
6* ESR1_21235772_ChIP-Seq_MCF-7_Human2.97361247
7GBX2_23144817_ChIP-Seq_PC3_Human2.94743262
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.91790911
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.76957420
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69890534
11ZNF274_21170338_ChIP-Seq_K562_Hela2.69224334
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59812120
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.52515891
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.49510793
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48133485
16CLOCK_20551151_ChIP-Seq_293T_Human2.44335779
17EZH2_22144423_ChIP-Seq_EOC_Human2.42076932
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38426161
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35359400
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.34421914
21IGF1R_20145208_ChIP-Seq_DFB_Human2.33051217
22FUS_26573619_Chip-Seq_HEK293_Human2.30354676
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.29885416
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26562299
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.21975161
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.18838622
27EWS_26573619_Chip-Seq_HEK293_Human2.14155039
28TAF15_26573619_Chip-Seq_HEK293_Human2.12163196
29GATA2_21666600_ChIP-Seq_HMVEC_Human2.07312137
30ESR2_21235772_ChIP-Seq_MCF-7_Human2.04664696
31* P300_19829295_ChIP-Seq_ESCs_Human2.02298731
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.99774201
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98540181
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96719084
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95161317
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85291295
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81768745
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.78412750
39GATA1_22025678_ChIP-Seq_K562_Human1.77773962
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76453843
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73344792
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.72087221
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65247964
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65193736
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65067650
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63262317
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.62019265
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61857447
49* SOX2_20726797_ChIP-Seq_SW620_Human1.61717524
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61385007
51* SMAD4_21799915_ChIP-Seq_A2780_Human1.60160893
52RNF2_27304074_Chip-Seq_NSC_Mouse1.54197508
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53578077
54* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52161529
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.50648444
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48949340
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.47185986
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46871022
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44495761
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42745502
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41232699
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40260229
63REST_21632747_ChIP-Seq_MESCs_Mouse1.39811458
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39138952
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39079613
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39026852
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.38344391
68GATA4_25053715_ChIP-Seq_YYC3_Human1.38120715
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38115709
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37743877
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.34245191
72AR_25329375_ChIP-Seq_VCAP_Human1.32789354
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.31760501
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.30994127
75SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30414364
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29635251
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29280833
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29233149
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29003145
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28575073
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27588815
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27155174
83EST1_17652178_ChIP-ChIP_JURKAT_Human1.27073867
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.26482673
85IRF1_19129219_ChIP-ChIP_H3396_Human1.24372467
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24183174
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23140536
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.23080981
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22393226
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.21919406
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.21919406
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20797233
93CJUN_26792858_Chip-Seq_BT549_Human1.19940395
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19514000
95ER_23166858_ChIP-Seq_MCF-7_Human1.19050910
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.18797504
97* STAT3_23295773_ChIP-Seq_U87_Human1.17110982
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17033341
99PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16801458
100* FOXA2_19822575_ChIP-Seq_HepG2_Human1.16653025
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16331839
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15297971
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15297971
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14460683
105VDR_22108803_ChIP-Seq_LS180_Human1.13284727
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12525766
107GABP_17652178_ChIP-ChIP_JURKAT_Human1.12299208
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11424281
109* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11385326
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11231543
111EED_16625203_ChIP-ChIP_MESCs_Mouse1.11014479
112ELK1_19687146_ChIP-ChIP_HELA_Human1.09921045
113MYC_18940864_ChIP-ChIP_HL60_Human1.09304415
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09177537
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07770451
116* TCF4_23295773_ChIP-Seq_U87_Human1.07682658
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.07283093
118* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07221231
119* REST_18959480_ChIP-ChIP_MESCs_Mouse1.06984430
120* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06710489
121* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06710489
122IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06709016
123CBP_20019798_ChIP-Seq_JUKART_Human1.06701424
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06701424
125RUNX2_22187159_ChIP-Seq_PCA_Human1.06001409
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05727875
127SOX9_26525672_Chip-Seq_HEART_Mouse1.04914746
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04910280
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04898642
130BCAT_22108803_ChIP-Seq_LS180_Human1.03446251
131TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02173090
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02010001
133SOX2_21211035_ChIP-Seq_LN229_Gbm1.01946181
134* RACK7_27058665_Chip-Seq_MCF-7_Human1.01904877
135* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01514234
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01322401
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01193180
138* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00937718
139JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00770083
140* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00514090
141AR_21572438_ChIP-Seq_LNCaP_Human1.00415476
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00337760
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00281097
144FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99551341
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.99277833
146* HNF4A_19822575_ChIP-Seq_HepG2_Human0.98810984
147SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98584090
148P53_22387025_ChIP-Seq_ESCs_Mouse0.98331818
149GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97902154
150KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96261127
151NANOG_16153702_ChIP-ChIP_HESCs_Human0.95991776
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.95643576
153* EZH2_27294783_Chip-Seq_NPCs_Mouse0.95567881
154LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95321210
155LXR_22292898_ChIP-Seq_THP-1_Human0.94333246
156NFE2_27457419_Chip-Seq_LIVER_Mouse0.94323872
157* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93531021
158GATA1_19941826_ChIP-Seq_K562_Human0.92656059
159RXR_22108803_ChIP-Seq_LS180_Human0.92513551
160NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92352743
161CDX2_22108803_ChIP-Seq_LS180_Human0.92345550
162GATA6_25053715_ChIP-Seq_YYC3_Human0.91505051
163TP63_23658742_ChIP-Seq_EP156T_Human0.90911953
164ARNT_22903824_ChIP-Seq_MCF-7_Human0.89696396
165GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88364506
166ESR1_20079471_ChIP-ChIP_T-47D_Human0.88069788
167* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87934327
168GATA2_19941826_ChIP-Seq_K562_Human0.87891306
169SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86211399
170WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84925143
171TCF4_18268006_ChIP-ChIP_LS174T_Human0.79849335
172AHR_22903824_ChIP-Seq_MCF-7_Human0.78997390
173KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77111188
174CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76389216
175P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76353616
176ERG_21242973_ChIP-ChIP_JURKAT_Human0.76095856
177SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76044878
178AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75677172
179TCF4_22108803_ChIP-Seq_LS180_Human0.75508248
180* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.75008171
181GATA3_24758297_ChIP-Seq_MCF-7_Human0.73792704
182* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.73227222
183IRF8_22096565_ChIP-ChIP_GC-B_Human0.72493618
184RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71744692
185* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.71451293
186EGR1_19032775_ChIP-ChIP_M12_Human0.70288622
187WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.69905116
188FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.69726564
189PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.69586460
190SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.68626336
191* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.68607269
192FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.68175321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.31169954
2MP0004043_abnormal_pH_regulation5.76084277
3MP0004019_abnormal_vitamin_homeostasis4.47478840
4MP0002138_abnormal_hepatobiliary_system3.99274719
5MP0002139_abnormal_hepatobiliary_system3.97078923
6MP0005332_abnormal_amino_acid3.81851804
7MP0001958_emphysema3.51900772
8MP0009643_abnormal_urine_homeostasis3.46391759
9MP0001765_abnormal_ion_homeostasis3.36523274
10MP0003195_calcinosis3.34456720
11MP0003122_maternal_imprinting3.03699140
12MP0008875_abnormal_xenobiotic_pharmacok2.98015399
13MP0001984_abnormal_olfaction2.87022984
14MP0001756_abnormal_urination2.76974262
15MP0005636_abnormal_mineral_homeostasis2.62329568
16MP0000566_synostosis2.42864299
17MP0002136_abnormal_kidney_physiology2.32600473
18MP0005365_abnormal_bile_salt2.18276805
19MP0003880_abnormal_central_pattern2.12802636
20MP0003121_genomic_imprinting2.12690753
21MP0003252_abnormal_bile_duct2.06342194
22MP0000778_abnormal_nervous_system2.05854213
23MP0000631_abnormal_neuroendocrine_gland2.05382813
24MP0005085_abnormal_gallbladder_physiolo2.04558005
25MP0003787_abnormal_imprinting1.95499701
26MP0003878_abnormal_ear_physiology1.94231355
27MP0005377_hearing/vestibular/ear_phenot1.94231355
28MP0005167_abnormal_blood-brain_barrier1.89805397
29MP0005058_abnormal_lysosome_morphology1.88403237
30MP0006072_abnormal_retinal_apoptosis1.85824497
31MP0006276_abnormal_autonomic_nervous1.81970781
32MP0002822_catalepsy1.80420183
33MP0002938_white_spotting1.77927122
34MP0003283_abnormal_digestive_organ1.76305767
35MP0008877_abnormal_DNA_methylation1.75040440
36MP0000639_abnormal_adrenal_gland1.74161949
37MP0002638_abnormal_pupillary_reflex1.74119051
38MP0001293_anophthalmia1.72708473
39MP0003300_gastrointestinal_ulcer1.72059698
40MP0005253_abnormal_eye_physiology1.70774923
41MP0003724_increased_susceptibility_to1.69012410
42MP0003136_yellow_coat_color1.68161794
43MP0005084_abnormal_gallbladder_morpholo1.67942311
44MP0008995_early_reproductive_senescence1.66758507
45MP0008789_abnormal_olfactory_epithelium1.64416111
46MP0009780_abnormal_chondrocyte_physiolo1.63341157
47MP0005394_taste/olfaction_phenotype1.62110117
48MP0005499_abnormal_olfactory_system1.62110117
49MP0002234_abnormal_pharynx_morphology1.60047386
50MP0004272_abnormal_basement_membrane1.59308948
51MP0010368_abnormal_lymphatic_system1.58905657
52MP0004133_heterotaxia1.57411278
53MP0001879_abnormal_lymphatic_vessel1.57119596
54MP0004147_increased_porphyrin_level1.56105730
55MP0002837_dystrophic_cardiac_calcinosis1.53607752
56MP0001529_abnormal_vocalization1.52381032
57MP0002653_abnormal_ependyma_morphology1.52296518
58MP0000538_abnormal_urinary_bladder1.50595331
59MP0004264_abnormal_extraembryonic_tissu1.50430412
60MP0006054_spinal_hemorrhage1.49185367
61MP0010030_abnormal_orbit_morphology1.48958550
62MP0004782_abnormal_surfactant_physiolog1.48823520
63MP0003119_abnormal_digestive_system1.48219364
64MP0001485_abnormal_pinna_reflex1.45469057
65MP0002557_abnormal_social/conspecific_i1.41946541
66MP0002102_abnormal_ear_morphology1.41067677
67MP0004510_myositis1.39540937
68MP0002876_abnormal_thyroid_physiology1.39483643
69MP0009046_muscle_twitch1.39469520
70MP0003937_abnormal_limbs/digits/tail_de1.38044740
71MP0003890_abnormal_embryonic-extraembry1.35434787
72MP0001486_abnormal_startle_reflex1.33915935
73MP0003191_abnormal_cellular_cholesterol1.32027120
74MP0008961_abnormal_basal_metabolism1.30992499
75MP0002233_abnormal_nose_morphology1.29989435
76MP0002896_abnormal_bone_mineralization1.26872525
77MP0005248_abnormal_Harderian_gland1.26655844
78MP0001666_abnormal_nutrient_absorption1.25598314
79MP0000230_abnormal_systemic_arterial1.22954630
80MP0002928_abnormal_bile_duct1.22380966
81MP0005551_abnormal_eye_electrophysiolog1.22088402
82MP0005187_abnormal_penis_morphology1.21533165
83MP0001299_abnormal_eye_distance/1.20660038
84MP0009745_abnormal_behavioral_response1.20628758
85MP0003638_abnormal_response/metabolism_1.19848984
86MP0000647_abnormal_sebaceous_gland1.19134139
87MP0005391_vision/eye_phenotype1.18788472
88MP0002572_abnormal_emotion/affect_behav1.18587138
89MP0003011_delayed_dark_adaptation1.17800211
90MP0004142_abnormal_muscle_tone1.17747313
91MP0002751_abnormal_autonomic_nervous1.17648367
92MP0004270_analgesia1.17237045
93MP0005408_hypopigmentation1.17218729
94MP0010386_abnormal_urinary_bladder1.16126348
95MP0002272_abnormal_nervous_system1.15947795
96MP0004859_abnormal_synaptic_plasticity1.15767540
97MP0005584_abnormal_enzyme/coenzyme_acti1.14812614
98MP0002697_abnormal_eye_size1.12765747
99MP0002184_abnormal_innervation1.12680613
100MP0000955_abnormal_spinal_cord1.12315311
101MP0000026_abnormal_inner_ear1.12290105
102MP0002736_abnormal_nociception_after1.12158116
103MP0000049_abnormal_middle_ear1.11286559
104MP0004885_abnormal_endolymph1.11202535
105MP0003635_abnormal_synaptic_transmissio1.10783085
106MP0000013_abnormal_adipose_tissue1.10291244
107MP0003938_abnormal_ear_development1.09030536
108MP0002063_abnormal_learning/memory/cond1.08667382
109MP0005646_abnormal_pituitary_gland1.08652595
110MP0003186_abnormal_redox_activity1.07848728
111MP0005319_abnormal_enzyme/_coenzyme1.06993955
112MP0002734_abnormal_mechanical_nocicepti1.05786998
113MP0002168_other_aberrant_phenotype1.04671189
114MP0002160_abnormal_reproductive_system1.02828630
115MP0002064_seizures1.02401598
116MP0003861_abnormal_nervous_system1.00348963
117MP0008058_abnormal_DNA_repair0.99936898
118MP0001764_abnormal_homeostasis0.99273130
119MP0010234_abnormal_vibrissa_follicle0.98669706
120MP0003279_aneurysm0.97494678
121MP0001286_abnormal_eye_development0.97278774
122MP0002877_abnormal_melanocyte_morpholog0.95975357
123MP0001968_abnormal_touch/_nociception0.95831664
124MP0002152_abnormal_brain_morphology0.95684266
125MP0005220_abnormal_exocrine_pancreas0.95371502
126MP0002118_abnormal_lipid_homeostasis0.93366378
127MP0002135_abnormal_kidney_morphology0.92408076
128MP0002752_abnormal_somatic_nervous0.91462986
129MP0002882_abnormal_neuron_morphology0.91353826
130MP0000678_abnormal_parathyroid_gland0.91073002
131MP0005195_abnormal_posterior_eye0.88999998
132MP0005379_endocrine/exocrine_gland_phen0.88708187
133MP0009672_abnormal_birth_weight0.88179227
134MP0010329_abnormal_lipoprotein_level0.86821261
135MP0002796_impaired_skin_barrier0.85064771
136MP0005535_abnormal_body_temperature0.84462291
137MP0003755_abnormal_palate_morphology0.84036663
138MP0009703_decreased_birth_body0.81846307
139MP0002735_abnormal_chemical_nociception0.80869355
140MP0004811_abnormal_neuron_physiology0.79975485
141MP0008004_abnormal_stomach_pH0.79895924
142MP0001963_abnormal_hearing_physiology0.79296817
143MP0005165_increased_susceptibility_to0.78725843
144MP0001970_abnormal_pain_threshold0.78427397
145MP0002067_abnormal_sensory_capabilities0.77516237
146MP0005670_abnormal_white_adipose0.77092794
147MP0005645_abnormal_hypothalamus_physiol0.76677635
148MP0003806_abnormal_nucleotide_metabolis0.75834137
149MP0002092_abnormal_eye_morphology0.75527813
150MP0001944_abnormal_pancreas_morphology0.74918092
151MP0001502_abnormal_circadian_rhythm0.74378258
152MP0003567_abnormal_fetal_cardiomyocyte0.74313024
153MP0002078_abnormal_glucose_homeostasis0.74130433
154MP0002090_abnormal_vision0.74127163
155MP0003698_abnormal_male_reproductive0.74103098
156MP0003172_abnormal_lysosome_physiology0.74088245
157MP0001929_abnormal_gametogenesis0.74050704
158MP0000427_abnormal_hair_cycle0.74046176
159MP0000371_diluted_coat_color0.73570043
160MP0006036_abnormal_mitochondrial_physio0.72935201
161MP0002108_abnormal_muscle_morphology0.72285043
162MP0006292_abnormal_olfactory_placode0.69862407
163MP0009642_abnormal_blood_homeostasis0.68315545
164MP0000749_muscle_degeneration0.67326120
165MP0003879_abnormal_hair_cell0.66936059
166MP0003566_abnormal_cell_adhesion0.65626230
167MP0002098_abnormal_vibrissa_morphology0.65282576
168MP0002089_abnormal_postnatal_growth/wei0.64811395
169MP0009764_decreased_sensitivity_to0.63156715
170MP0005595_abnormal_vascular_smooth0.61859689
171MP0001664_abnormal_digestion0.57963109
172MP0005666_abnormal_adipose_tissue0.57402003
173MP0002998_abnormal_bone_remodeling0.57003846
174MP0000609_abnormal_liver_physiology0.56353478
175MP0005395_other_phenotype0.55295402
176MP0003953_abnormal_hormone_level0.54985945
177MP0002295_abnormal_pulmonary_circulatio0.54677849
178MP0001177_atelectasis0.53405047
179MP0004130_abnormal_muscle_cell0.51670782
180MP0002909_abnormal_adrenal_gland0.50669591
181MP0005388_respiratory_system_phenotype0.50030012
182MP0002133_abnormal_respiratory_system0.50030012
183MP0003959_abnormal_lean_body0.49555656
184MP0004484_altered_response_of0.48915158
185MP0003795_abnormal_bone_structure0.47534297
186MP0002115_abnormal_skeleton_extremities0.45496379
187MP0000598_abnormal_liver_morphology0.44866645
188MP0005275_abnormal_skin_tensile0.42744597
189MP0001270_distended_abdomen0.42375157

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.59772317
2Hypokalemic alkalosis (HP:0001949)6.82071353
3Gout (HP:0001997)6.66397690
4Increased circulating renin level (HP:0000848)6.57322636
5Metabolic alkalosis (HP:0200114)6.33677321
6Abnormality of chloride homeostasis (HP:0011422)6.06510285
7Hypomagnesemia (HP:0002917)5.97705149
8Polyuria (HP:0000103)5.40738201
9Abnormal urine output (HP:0012590)5.33145467
10Abnormality of renal excretion (HP:0011036)5.22521490
11Abnormality of magnesium homeostasis (HP:0004921)5.13869484
12Abnormality of renin-angiotensin system (HP:0000847)5.03141682
13Renal salt wasting (HP:0000127)4.87824948
14Hyperaldosteronism (HP:0000859)4.82713571
15Increased purine levels (HP:0004368)4.71945723
16Hyperuricemia (HP:0002149)4.71945723
17Proximal tubulopathy (HP:0000114)4.57499020
18Alkalosis (HP:0001948)4.41362832
19Tetany (HP:0001281)4.40261695
20Abnormality of purine metabolism (HP:0004352)4.39249997
21Abnormal drinking behavior (HP:0030082)4.33994539
22Polydipsia (HP:0001959)4.33994539
23Hyperglycinuria (HP:0003108)4.26771416
24Ketoacidosis (HP:0001993)4.19831640
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.15725706
26Generalized aminoaciduria (HP:0002909)4.08224805
27Hypokalemia (HP:0002900)3.87612382
28Hypercalciuria (HP:0002150)3.45067498
29Abnormality of glycine metabolism (HP:0010895)3.36591125
30Abnormality of serine family amino acid metabolism (HP:0010894)3.36591125
31Ketosis (HP:0001946)3.36316846
32Hypoglycemic coma (HP:0001325)3.29538985
33Abnormality of potassium homeostasis (HP:0011042)3.27047143
34Glycosuria (HP:0003076)3.09367869
35Abnormality of urine glucose concentration (HP:0011016)3.09367869
36Abnormality of the labia minora (HP:0012880)3.05977069
37Abnormality of nucleobase metabolism (HP:0010932)3.00805522
38Renal tubular acidosis (HP:0001947)2.97641324
39Enlarged penis (HP:0000040)2.96968360
40Abnormality of fatty-acid metabolism (HP:0004359)2.92696902
41Decreased circulating renin level (HP:0003351)2.86208810
42Widely patent fontanelles and sutures (HP:0004492)2.75944034
43Hyperphosphaturia (HP:0003109)2.75043009
44Nephrolithiasis (HP:0000787)2.74692068
45Abnormality of proline metabolism (HP:0010907)2.71362067
46Hydroxyprolinuria (HP:0003080)2.71362067
47Medial flaring of the eyebrow (HP:0010747)2.70870573
48Colon cancer (HP:0003003)2.70131037
49Gait imbalance (HP:0002141)2.64461489
50Abnormal urine phosphate concentration (HP:0012599)2.63061742
51Hypoglycemic seizures (HP:0002173)2.60965363
52Potter facies (HP:0002009)2.60399953
53Facial shape deformation (HP:0011334)2.60399953
54Nephronophthisis (HP:0000090)2.59937079
55Aplasia/hypoplasia of the uterus (HP:0008684)2.58946491
56Pancreatic cysts (HP:0001737)2.57455151
57Symptomatic seizures (HP:0011145)2.52504411
58Vascular calcification (HP:0004934)2.51860293
59Pancreatic fibrosis (HP:0100732)2.50515286
60Adrenal overactivity (HP:0002717)2.50457688
61Dehydration (HP:0001944)2.47571083
62Congenital primary aphakia (HP:0007707)2.47218441
63Hyponatremia (HP:0002902)2.47042650
64Genital tract atresia (HP:0001827)2.45338732
65Delayed CNS myelination (HP:0002188)2.44362594
66Hypophosphatemia (HP:0002148)2.44252655
67Nephrocalcinosis (HP:0000121)2.44188763
68Vacuolated lymphocytes (HP:0001922)2.40946256
69Delayed epiphyseal ossification (HP:0002663)2.40059809
70Molar tooth sign on MRI (HP:0002419)2.38182802
71Abnormality of midbrain morphology (HP:0002418)2.38182802
72Vaginal atresia (HP:0000148)2.36030356
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34641550
74True hermaphroditism (HP:0010459)2.34158389
75Cardiovascular calcification (HP:0011915)2.34140953
76Nephrogenic diabetes insipidus (HP:0009806)2.33938634
77Hyperkalemia (HP:0002153)2.31616404
78Hyperinsulinemic hypoglycemia (HP:0000825)2.30751430
79Abnormality of sodium homeostasis (HP:0010931)2.30609549
80Abnormality of the renal medulla (HP:0100957)2.29750996
81Hyperglycinemia (HP:0002154)2.29719159
82Hypotension (HP:0002615)2.29609700
83Oligodactyly (hands) (HP:0001180)2.28500111
84Intestinal atresia (HP:0011100)2.28422734
85Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27865559
86Confusion (HP:0001289)2.27848388
87Rickets (HP:0002748)2.22458626
88Thin bony cortex (HP:0002753)2.22438831
89Metaphyseal cupping (HP:0003021)2.21721155
90Hepatoblastoma (HP:0002884)2.21255255
91Metabolic acidosis (HP:0001942)2.20791590
92Dicarboxylic aciduria (HP:0003215)2.20042854
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20042854
94Male pseudohermaphroditism (HP:0000037)2.17835368
95Decreased testicular size (HP:0008734)2.17004331
96Chronic bronchitis (HP:0004469)2.11671308
97Drooling (HP:0002307)2.10054306
98Optic nerve hypoplasia (HP:0000609)2.09530629
99Tubulointerstitial fibrosis (HP:0005576)2.09283458
100Hyperammonemia (HP:0001987)2.08533426
101Labial hypoplasia (HP:0000066)2.07631411
102Thyroid-stimulating hormone excess (HP:0002925)2.07399597
103Late onset (HP:0003584)2.06287263
104Hypoplasia of the uterus (HP:0000013)2.05834446
105Enlarged kidneys (HP:0000105)2.05740498
106Abnormal respiratory epithelium morphology (HP:0012253)2.05076253
107Abnormal respiratory motile cilium morphology (HP:0005938)2.05076253
108Abnormal ciliary motility (HP:0012262)2.04674788
109Tachypnea (HP:0002789)2.02953471
110Postaxial hand polydactyly (HP:0001162)2.02094315
111Hypsarrhythmia (HP:0002521)1.99151578
112Septo-optic dysplasia (HP:0100842)1.98325600
113Hypothermia (HP:0002045)1.98255864
114Lymphangioma (HP:0100764)1.98071960
115Scrotal hypoplasia (HP:0000046)1.97017617
116Mucopolysacchariduria (HP:0008155)1.96621712
117Urinary glycosaminoglycan excretion (HP:0003541)1.96621712
118Vomiting (HP:0002013)1.96424918
119Anophthalmia (HP:0000528)1.95804199
120Polycythemia (HP:0001901)1.95192776
121Hypoplastic female external genitalia (HP:0012815)1.94728120
122Abnormal enzyme/coenzyme activity (HP:0012379)1.94613262
123Gastrointestinal atresia (HP:0002589)1.94170578
124Chondrocalcinosis (HP:0000934)1.93886252
125EEG with generalized epileptiform discharges (HP:0011198)1.93791117
126Renal hypoplasia (HP:0000089)1.93057765
127Rhinitis (HP:0012384)1.91814352
128Epileptiform EEG discharges (HP:0011182)1.90475703
129Abnormality of alkaline phosphatase activity (HP:0004379)1.89364572
130Abnormal sex determination (HP:0012244)1.89223361
131Sex reversal (HP:0012245)1.89223361
132Abnormality of the costochondral junction (HP:0000919)1.89217573
133Polyphagia (HP:0002591)1.88153422
134Abnormality of calcium-phosphate metabolism (HP:0100530)1.87486477
135Dysostosis multiplex (HP:0000943)1.86463504
136Split foot (HP:0001839)1.85872669
137Methylmalonic aciduria (HP:0012120)1.85615143
138Malnutrition (HP:0004395)1.85540114
139Type II lissencephaly (HP:0007260)1.84805110
140Abnormality of the metopic suture (HP:0005556)1.84677565
141Bicornuate uterus (HP:0000813)1.83219499
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83144819
143Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82196296
144Chronic hepatic failure (HP:0100626)1.81982740
145Excessive salivation (HP:0003781)1.81774088
146Limb dystonia (HP:0002451)1.81275758
147Aqueductal stenosis (HP:0002410)1.81019837
148Abnormality of Sharpey fibers (HP:0100685)1.80846864
149Micropenis (HP:0000054)1.79865154
150Occipital encephalocele (HP:0002085)1.79738107
151Wide cranial sutures (HP:0010537)1.79516451
152Abnormal respiratory motile cilium physiology (HP:0012261)1.79407957
153Renal tubular dysfunction (HP:0000124)1.79177212
154Abnormality of polysaccharide metabolism (HP:0011012)1.78361450
155Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78361450
156Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78361450
157Poor coordination (HP:0002370)1.75208884
158Specific learning disability (HP:0001328)1.75043165
159Esophageal atresia (HP:0002032)1.75013059
160Oligodactyly (HP:0012165)1.74956192
161Tubular atrophy (HP:0000092)1.74627088
162Cutaneous finger syndactyly (HP:0010554)1.71288982
163Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69773544
164Neoplasm of the adrenal cortex (HP:0100641)1.69490264
165Broad foot (HP:0001769)1.68487638
166Retinal dysplasia (HP:0007973)1.66701637
167Hyperglycemia (HP:0003074)1.65266220
168Lissencephaly (HP:0001339)1.64867483
169Hypoplastic pelvis (HP:0008839)1.64689463
170Progressive macrocephaly (HP:0004481)1.63557854
171Clitoromegaly (HP:0000057)1.63543099
172Bilateral microphthalmos (HP:0007633)1.61266361
173Large earlobe (HP:0009748)1.60966005
174Hemiparesis (HP:0001269)1.59185893
175Hemivertebrae (HP:0002937)1.58866627
176Hypoplastic labia majora (HP:0000059)1.56476618

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK37.10009554
2WNK46.86513090
3OXSR15.20126740
4TIE14.03234367
5CASK3.09338630
6FGFR22.96514987
7MAP3K42.88156998
8TNIK2.75609227
9BCKDK2.62711729
10MARK12.58451853
11STK392.57262000
12TGFBR22.52941074
13KDR2.25976971
14MAP2K72.20455234
15TRIM282.18922219
16ERN12.05830899
17MAPK152.01195426
18BCR1.88472569
19MST41.87439562
20DYRK21.84618343
21EPHB11.77348326
22INSRR1.75589980
23PNCK1.73994229
24MKNK11.59300566
25MKNK21.56634558
26PDK31.54944764
27PDK41.54944764
28SRPK11.53728329
29CSNK1G21.51869770
30PLK31.51369307
31STK38L1.50453154
32WNK11.49690392
33FGFR41.47488011
34CSNK1G11.46672442
35CAMKK21.44906059
36ERBB31.43665695
37CSNK1A1L1.39762139
38CSNK1G31.36880230
39GRK11.35217169
40TSSK61.33096500
41SGK2231.32945618
42SGK4941.32945618
43EPHA41.30583187
44FER1.29115436
45LRRK21.26847263
46MAPK131.26758486
47ZAK1.26497751
48PDK21.25434617
49NTRK31.21414160
50MST1R1.18098499
51VRK21.17831146
52NTRK21.15374983
53CDC71.14700070
54DYRK31.14445167
55UHMK11.10750372
56BMPR1B1.10457831
57MYLK1.09252074
58FRK1.09202801
59MAP4K21.08598308
60PTK61.07260878
61PAK41.06171568
62PRKCG1.05539462
63PTK21.03226857
64VRK11.01660966
65NEK10.96339609
66PLK20.94033505
67TTK0.93540319
68SGK20.92317669
69PLK40.90737668
70RIPK10.87931457
71EPHA30.86488457
72NUAK10.85969218
73TAF10.85336710
74MAP2K40.83356171
75PAK30.82344720
76TRIB30.81464740
77PINK10.81457189
78TGFBR10.80782011
79SGK30.80276786
80WEE10.79191670
81GSK3A0.79167583
82BRD40.78628829
83PDPK10.77915879
84RPS6KA40.77651206
85MAP3K30.74349559
86PLK10.73979372
87PDGFRA0.72972341
88DYRK1A0.70996739
89MET0.70371662
90MAP3K20.69207929
91DYRK1B0.68965808
92BUB10.67636306
93SIK10.67155116
94ACVR1B0.65624339
95PTK2B0.64570077
96PRKAA20.64465596
97STK30.63745462
98PRKAA10.63373256
99CAMK1G0.63040378
100BRSK20.60160665
101MUSK0.59219556
102EPHB20.58328676
103STK380.58245932
104PRKG20.57431312
105CDK30.55803200
106NLK0.55639505
107ATM0.52613578
108YES10.50839932
109PDK10.50119758
110GRK60.49409626
111LATS10.48534390
112CSK0.48471676
113MAP2K30.48162372
114PRKCZ0.47735266
115CDK190.47313632
116HIPK20.45208288
117CSNK1A10.43935756
118MINK10.43543099
119ADRBK20.42982288
120STK240.42582192
121MATK0.41848298
122ATR0.41715095
123PRKCH0.41458702
124TBK10.41337916
125CAMK1D0.40248785
126PRKDC0.39882322
127FGFR30.39676728
128CAMK2A0.39504688
129CDK50.39381944
130MAPK110.39379882
131SGK10.39078351
132AKT30.37882827
133DDR20.37607002
134CSNK1E0.37184644
135CSNK1D0.36986334
136PRKD20.36836209
137CHEK20.36575904
138JAK20.36444505
139FGFR10.35974879
140CAMK2D0.35792942
141PRKACB0.32964969
142NEK90.32276965
143MAP3K70.30929248
144NTRK10.29395898
145STK160.29058444
146DAPK20.28890154
147IRAK10.28870515
148PRKCE0.28370518
149JAK10.28229663
150LMTK20.27901525
151IRAK30.27636381
152MAP2K20.27604387
153PRKACG0.27006195
154PIK3CG0.26758428
155STK110.26654628
156PRKCI0.25193563
157RPS6KA20.24225665
158PASK0.23473202
159MAP2K10.22636912
160IGF1R0.22446457
161MAP3K10.22322965
162MAP3K140.21239880
163ADRBK10.20671365
164PHKG20.19129509
165PHKG10.19129509
166CAMKK10.16831483
167PRKACA0.16779718
168SCYL20.16591911
169RET0.16306901
170PRKCD0.15857229
171MAP3K120.15309256

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.14018202
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.10218326
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.10060043
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.85004936
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.84441844
6Propanoate metabolism_Homo sapiens_hsa006402.83457667
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.62548498
8Protein export_Homo sapiens_hsa030602.61062559
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61036250
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.55227416
11Tryptophan metabolism_Homo sapiens_hsa003802.42797796
12Steroid biosynthesis_Homo sapiens_hsa001002.40020265
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.38719893
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.38575496
15Fatty acid degradation_Homo sapiens_hsa000712.38167544
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32996819
17Peroxisome_Homo sapiens_hsa041462.29969651
18Vitamin digestion and absorption_Homo sapiens_hsa049772.22791118
19Vitamin B6 metabolism_Homo sapiens_hsa007502.14987736
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.14094725
21Sulfur metabolism_Homo sapiens_hsa009202.07316969
22Nitrogen metabolism_Homo sapiens_hsa009102.00830077
23Pyruvate metabolism_Homo sapiens_hsa006202.00438176
24Collecting duct acid secretion_Homo sapiens_hsa049661.93908819
25Nicotine addiction_Homo sapiens_hsa050331.91187271
26Bile secretion_Homo sapiens_hsa049761.79119431
27beta-Alanine metabolism_Homo sapiens_hsa004101.77600324
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75957344
29Fatty acid metabolism_Homo sapiens_hsa012121.70181235
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58890380
31Fanconi anemia pathway_Homo sapiens_hsa034601.53661519
32Basal cell carcinoma_Homo sapiens_hsa052171.51453454
33Ovarian steroidogenesis_Homo sapiens_hsa049131.50724993
34Protein digestion and absorption_Homo sapiens_hsa049741.48627316
35Mineral absorption_Homo sapiens_hsa049781.45399924
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45067416
37Parkinsons disease_Homo sapiens_hsa050121.43827920
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42980075
39Non-homologous end-joining_Homo sapiens_hsa034501.39919130
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38700758
41Histidine metabolism_Homo sapiens_hsa003401.38649630
42Hedgehog signaling pathway_Homo sapiens_hsa043401.38625640
43Selenocompound metabolism_Homo sapiens_hsa004501.29744495
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29254984
45Other glycan degradation_Homo sapiens_hsa005111.27687862
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26805230
47Arginine and proline metabolism_Homo sapiens_hsa003301.24436829
48Starch and sucrose metabolism_Homo sapiens_hsa005001.24263476
49Phototransduction_Homo sapiens_hsa047441.22417874
50PPAR signaling pathway_Homo sapiens_hsa033201.22066451
51Carbon metabolism_Homo sapiens_hsa012001.21369525
52Basal transcription factors_Homo sapiens_hsa030221.21040879
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18809879
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18080798
55Huntingtons disease_Homo sapiens_hsa050161.16019836
56Glutathione metabolism_Homo sapiens_hsa004801.14969499
57Arginine biosynthesis_Homo sapiens_hsa002201.12137754
58Taste transduction_Homo sapiens_hsa047421.11641634
59RNA polymerase_Homo sapiens_hsa030201.10458301
60Folate biosynthesis_Homo sapiens_hsa007901.10283901
61Homologous recombination_Homo sapiens_hsa034401.08730021
62GABAergic synapse_Homo sapiens_hsa047271.06895531
63RNA degradation_Homo sapiens_hsa030181.03327326
64Lysine degradation_Homo sapiens_hsa003101.02448277
65Mismatch repair_Homo sapiens_hsa034300.99358343
66Phenylalanine metabolism_Homo sapiens_hsa003600.98939800
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95751526
68Alzheimers disease_Homo sapiens_hsa050100.95140896
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.93914477
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93889282
71Hippo signaling pathway_Homo sapiens_hsa043900.92295716
72Lysosome_Homo sapiens_hsa041420.91600127
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.89645190
74Cardiac muscle contraction_Homo sapiens_hsa042600.88209734
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87957174
76Renin-angiotensin system_Homo sapiens_hsa046140.87786025
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86786692
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86056892
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86031205
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85709333
81Axon guidance_Homo sapiens_hsa043600.84819131
82Circadian entrainment_Homo sapiens_hsa047130.84054521
83One carbon pool by folate_Homo sapiens_hsa006700.83321481
84Fructose and mannose metabolism_Homo sapiens_hsa000510.81360944
85Dopaminergic synapse_Homo sapiens_hsa047280.80733230
86Spliceosome_Homo sapiens_hsa030400.79892862
87Glycerolipid metabolism_Homo sapiens_hsa005610.79892785
88Cocaine addiction_Homo sapiens_hsa050300.78581964
89Glutamatergic synapse_Homo sapiens_hsa047240.78360478
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77117712
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77044481
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76125360
93mRNA surveillance pathway_Homo sapiens_hsa030150.74981643
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74275532
95ABC transporters_Homo sapiens_hsa020100.73518571
96Nucleotide excision repair_Homo sapiens_hsa034200.72673752
97Morphine addiction_Homo sapiens_hsa050320.70748429
98Ether lipid metabolism_Homo sapiens_hsa005650.67335735
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67139440
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65123528
101Fatty acid elongation_Homo sapiens_hsa000620.64994538
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63116832
103Chemical carcinogenesis_Homo sapiens_hsa052040.63073585
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62908476
105Wnt signaling pathway_Homo sapiens_hsa043100.62782261
106Oocyte meiosis_Homo sapiens_hsa041140.61740904
107RNA transport_Homo sapiens_hsa030130.61543802
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60757404
109Amphetamine addiction_Homo sapiens_hsa050310.60729482
110Vibrio cholerae infection_Homo sapiens_hsa051100.59668772
111Thyroid hormone synthesis_Homo sapiens_hsa049180.58942262
112Purine metabolism_Homo sapiens_hsa002300.58857675
113Base excision repair_Homo sapiens_hsa034100.56498431
114Serotonergic synapse_Homo sapiens_hsa047260.56238829
115Biosynthesis of amino acids_Homo sapiens_hsa012300.55590165
116Regulation of autophagy_Homo sapiens_hsa041400.54299297
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53478328
118Retinol metabolism_Homo sapiens_hsa008300.51892688
119Gastric acid secretion_Homo sapiens_hsa049710.51853311
120Type II diabetes mellitus_Homo sapiens_hsa049300.48304405
121Insulin resistance_Homo sapiens_hsa049310.47653422
122Galactose metabolism_Homo sapiens_hsa000520.47532606
123Linoleic acid metabolism_Homo sapiens_hsa005910.46353491
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.46091898
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45064553
126Tyrosine metabolism_Homo sapiens_hsa003500.44675819
127Olfactory transduction_Homo sapiens_hsa047400.44061406
128Metabolic pathways_Homo sapiens_hsa011000.39489356
129Caffeine metabolism_Homo sapiens_hsa002320.39211372
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.36186843
131Sphingolipid metabolism_Homo sapiens_hsa006000.34911205
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31620634
133Complement and coagulation cascades_Homo sapiens_hsa046100.27053804
134Insulin secretion_Homo sapiens_hsa049110.26177186
135Arachidonic acid metabolism_Homo sapiens_hsa005900.26052440
136ECM-receptor interaction_Homo sapiens_hsa045120.25911783
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.24822077
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.23208165
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.22692078
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22523124
141Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22113337
142Pentose phosphate pathway_Homo sapiens_hsa000300.20265179
143Circadian rhythm_Homo sapiens_hsa047100.20049652
144Pancreatic secretion_Homo sapiens_hsa049720.18808754
145Glucagon signaling pathway_Homo sapiens_hsa049220.18689758
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17640393
147Focal adhesion_Homo sapiens_hsa045100.16904916
148Tight junction_Homo sapiens_hsa045300.16695763
149Oxidative phosphorylation_Homo sapiens_hsa001900.14243858
150Synaptic vesicle cycle_Homo sapiens_hsa047210.13796477
151Rheumatoid arthritis_Homo sapiens_hsa053230.13505267
152Fat digestion and absorption_Homo sapiens_hsa049750.11553533
153Choline metabolism in cancer_Homo sapiens_hsa052310.11241041
154Inositol phosphate metabolism_Homo sapiens_hsa005620.11066639
155AMPK signaling pathway_Homo sapiens_hsa041520.10005116
156Phagosome_Homo sapiens_hsa041450.07726826
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.07497120
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07250020

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