SLC16A6P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.71672723
2nuclear pore organization (GO:0006999)6.57171311
3DNA replication initiation (GO:0006270)5.83915795
4regulation of translational fidelity (GO:0006450)5.83540907
5pore complex assembly (GO:0046931)5.47703167
6DNA unwinding involved in DNA replication (GO:0006268)5.24914501
7negative regulation of DNA repair (GO:0045738)5.24563973
8regulation of histone H3-K27 methylation (GO:0061085)5.00951736
9mitotic chromosome condensation (GO:0007076)4.66045905
10regulation of RNA export from nucleus (GO:0046831)4.57707315
11DNA topological change (GO:0006265)4.05447865
12mRNA cleavage (GO:0006379)4.00311025
13regulation of double-strand break repair via homologous recombination (GO:0010569)3.83912112
14mitotic sister chromatid segregation (GO:0000070)3.83116320
15sister chromatid segregation (GO:0000819)3.82624266
16DNA duplex unwinding (GO:0032508)3.80300058
17negative regulation of histone methylation (GO:0031061)3.79958676
18DNA synthesis involved in DNA repair (GO:0000731)3.77445862
19regulation of nucleobase-containing compound transport (GO:0032239)3.72642323
20mitotic nuclear envelope disassembly (GO:0007077)3.68875970
21DNA geometric change (GO:0032392)3.60947381
22mitotic sister chromatid cohesion (GO:0007064)3.57122936
23positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.54697787
24regulation of histone H3-K4 methylation (GO:0051569)3.44210839
25nuclear envelope disassembly (GO:0051081)3.43062364
26membrane disassembly (GO:0030397)3.43062364
27folic acid-containing compound biosynthetic process (GO:0009396)3.42742866
28regulation of double-strand break repair (GO:2000779)3.40833474
29regulation of translational elongation (GO:0006448)3.36739857
30formation of translation preinitiation complex (GO:0001731)3.36187070
31regulation of NFAT protein import into nucleus (GO:0051532)3.34945516
32DNA conformation change (GO:0071103)3.34366292
33chromosome condensation (GO:0030261)3.27515268
34protein export from nucleus (GO:0006611)3.26283219
35heterochromatin organization (GO:0070828)3.26064011
36RNA stabilization (GO:0043489)3.25140192
37mRNA stabilization (GO:0048255)3.25140192
38proline biosynthetic process (GO:0006561)3.23781272
39response to laminar fluid shear stress (GO:0034616)3.23751716
40ribosomal small subunit biogenesis (GO:0042274)3.18611297
41DNA strand elongation involved in DNA replication (GO:0006271)3.18253185
42positive regulation of protein import into nucleus, translocation (GO:0033160)3.17814304
43peptidyl-lysine dimethylation (GO:0018027)3.17593835
44COPII vesicle coating (GO:0048208)3.13807376
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.12391051
46regulation of histone methylation (GO:0031060)3.10725992
47DNA strand elongation (GO:0022616)3.10677318
48regulation of centriole replication (GO:0046599)3.09795727
49glucocorticoid receptor signaling pathway (GO:0042921)3.03811938
50pre-miRNA processing (GO:0031054)3.00672503
51poly(A)+ mRNA export from nucleus (GO:0016973)2.98710887
52histone deubiquitination (GO:0016578)2.98194489
53spliceosomal tri-snRNP complex assembly (GO:0000244)2.91435393
54Golgi transport vesicle coating (GO:0048200)2.88384165
55COPI coating of Golgi vesicle (GO:0048205)2.88384165
56DNA packaging (GO:0006323)2.87581433
57histone H3-K4 trimethylation (GO:0080182)2.86003346
58mRNA transport (GO:0051028)2.84287295
59DNA replication checkpoint (GO:0000076)2.83121890
60cytoplasmic mRNA processing body assembly (GO:0033962)2.82537752
61monoubiquitinated protein deubiquitination (GO:0035520)2.81596980
62definitive hemopoiesis (GO:0060216)2.81546685
63tetrahydrofolate metabolic process (GO:0046653)2.81267992
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80841196
65nuclear envelope organization (GO:0006998)2.80406302
66homocysteine metabolic process (GO:0050667)2.80365266
67folic acid metabolic process (GO:0046655)2.79643328
68histone H3-K9 demethylation (GO:0033169)2.78589403
69iron ion import (GO:0097286)2.76423227
70protoporphyrinogen IX metabolic process (GO:0046501)2.75891708
71regulation of centrosome cycle (GO:0046605)2.70431849
72histone H3-K4 methylation (GO:0051568)2.70129302
73establishment of mitotic spindle localization (GO:0040001)2.68518579
74dosage compensation (GO:0007549)2.67434596
75histone H3-K36 demethylation (GO:0070544)2.66549248
76TOR signaling (GO:0031929)2.65869049
77cranial suture morphogenesis (GO:0060363)2.64203297
78regulation of centrosome duplication (GO:0010824)2.63829965
79corticosteroid receptor signaling pathway (GO:0031958)2.62375726
80peptidyl-arginine omega-N-methylation (GO:0035247)2.58140473
81telomere maintenance via semi-conservative replication (GO:0032201)2.56896093
82response to vitamin A (GO:0033189)2.55891037
83protein localization to chromosome, centromeric region (GO:0071459)2.55751568
84folic acid-containing compound metabolic process (GO:0006760)2.55047976
85maturation of SSU-rRNA (GO:0030490)2.53822799
86positive regulation of cell cycle checkpoint (GO:1901978)2.53532082
87mannose metabolic process (GO:0006013)2.53137990
88negative regulation of fatty acid biosynthetic process (GO:0045717)2.52253405
89response to epidermal growth factor (GO:0070849)2.51862165
90regulation of mitotic spindle organization (GO:0060236)2.51831238
91non-recombinational repair (GO:0000726)2.50768554
92double-strand break repair via nonhomologous end joining (GO:0006303)2.50768554
93IMP biosynthetic process (GO:0006188)2.50114792
94mRNA export from nucleus (GO:0006406)2.49432696
95spindle organization (GO:0007051)2.47299493
96embryonic process involved in female pregnancy (GO:0060136)2.46536926
97protein-DNA complex disassembly (GO:0032986)2.45702782
98nucleosome disassembly (GO:0006337)2.45702782
99nucleic acid transport (GO:0050657)2.44949542
100establishment of RNA localization (GO:0051236)2.44949542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.26415550
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.46314295
3MYC_22102868_ChIP-Seq_BL_Human3.44258724
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.11125296
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.92295747
6ZNF263_19887448_ChIP-Seq_K562_Human2.73610364
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65479251
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63078067
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53957351
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41338556
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.36656504
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.33825293
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33664412
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32829006
15AR_21909140_ChIP-Seq_LNCAP_Human2.32285662
16VDR_21846776_ChIP-Seq_THP-1_Human2.15137250
17XRN2_22483619_ChIP-Seq_HELA_Human2.06273658
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04263166
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03640168
20CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.94957282
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.93858897
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91719156
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86371802
24KDM5A_27292631_Chip-Seq_BREAST_Human1.85447920
25CIITA_25753668_ChIP-Seq_RAJI_Human1.85098209
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74235031
27GATA1_22025678_ChIP-Seq_K562_Human1.73810332
28NCOR1_26117541_ChIP-Seq_K562_Human1.71467710
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67598867
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63303658
31DCP1A_22483619_ChIP-Seq_HELA_Human1.62630269
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61510731
33ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59305602
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.58797824
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57284470
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.52924538
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50765329
38CHD1_26751641_Chip-Seq_LNCaP_Human1.46491086
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44643159
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44313831
41CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.44125857
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41463668
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40069930
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37340384
45RACK7_27058665_Chip-Seq_MCF-7_Human1.36953899
46TTF2_22483619_ChIP-Seq_HELA_Human1.34673444
47TCF7_22412390_ChIP-Seq_EML_Mouse1.34115093
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33938647
49CLOCK_20551151_ChIP-Seq_293T_Human1.33315953
50TFEB_21752829_ChIP-Seq_HELA_Human1.30768797
51KDM2B_26808549_Chip-Seq_DND41_Human1.29511141
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.29279621
53GABP_19822575_ChIP-Seq_HepG2_Human1.25921991
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25763334
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24143734
56E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24122115
57PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21244306
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20815304
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20324862
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20001877
61MAF_26560356_Chip-Seq_TH1_Human1.19851594
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16512943
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15576364
64LXR_22292898_ChIP-Seq_THP-1_Human1.15482726
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15003385
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15001481
67MAF_26560356_Chip-Seq_TH2_Human1.13824211
68NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.12660552
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11940002
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11500460
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11430031
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.09861710
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08552678
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.08085809
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04690324
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04352022
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03969622
78GATA6_25053715_ChIP-Seq_YYC3_Human1.03761263
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03536434
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03358287
81ATF3_27146783_Chip-Seq_COLON_Human1.02739222
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02344595
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00401755
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98054433
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97479065
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97322316
87KDM2B_26808549_Chip-Seq_JURKAT_Human0.97270147
88CREB1_26743006_Chip-Seq_LNCaP_Human0.95873353
89UBF1/2_26484160_Chip-Seq_HMECs_Human0.92921628
90GATA1_19941826_ChIP-Seq_K562_Human0.92562772
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91990285
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.91401625
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90789294
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90563321
95UTX_26944678_Chip-Seq_JUKART_Human0.89885435
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89798435
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89047072
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87636109
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86976703
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86242781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.91332412
2MP0002009_preneoplasia3.38952223
3MP0003111_abnormal_nucleus_morphology3.22611197
4MP0010094_abnormal_chromosome_stability3.11597442
5MP0005451_abnormal_body_composition3.09887563
6MP0005076_abnormal_cell_differentiation2.85897941
7MP0003077_abnormal_cell_cycle2.64520676
8MP0002877_abnormal_melanocyte_morpholog2.57468487
9MP0003693_abnormal_embryo_hatching2.54191399
10MP0000537_abnormal_urethra_morphology2.51237307
11MP0004957_abnormal_blastocyst_morpholog2.45451942
12MP0002396_abnormal_hematopoietic_system2.33513461
13MP0008007_abnormal_cellular_replicative2.24604917
14MP0004233_abnormal_muscle_weight2.22910682
15MP0005058_abnormal_lysosome_morphology2.03709051
16MP0008995_early_reproductive_senescence2.03329217
17MP0003315_abnormal_perineum_morphology1.98654470
18MP0004808_abnormal_hematopoietic_stem1.97628347
19MP0001730_embryonic_growth_arrest1.87091978
20MP0001346_abnormal_lacrimal_gland1.82814784
21MP0001661_extended_life_span1.81112802
22MP0008058_abnormal_DNA_repair1.80672384
23MP0003705_abnormal_hypodermis_morpholog1.80385588
24MP0000350_abnormal_cell_proliferation1.73037467
25MP0009697_abnormal_copulation1.71245225
26MP0003984_embryonic_growth_retardation1.69853546
27MP0002088_abnormal_embryonic_growth/wei1.67338265
28MP0004185_abnormal_adipocyte_glucose1.65519142
29MP0001672_abnormal_embryogenesis/_devel1.61719994
30MP0005380_embryogenesis_phenotype1.61719994
31MP0003656_abnormal_erythrocyte_physiolo1.60809994
32MP0010307_abnormal_tumor_latency1.60126666
33MP0005409_darkened_coat_color1.52719896
34MP0004264_abnormal_extraembryonic_tissu1.49238843
35MP0002086_abnormal_extraembryonic_tissu1.45002320
36MP0005248_abnormal_Harderian_gland1.44080126
37MP0010030_abnormal_orbit_morphology1.41689208
38MP0001697_abnormal_embryo_size1.40175899
39MP0008932_abnormal_embryonic_tissue1.39788171
40MP0002080_prenatal_lethality1.36659763
41MP0005187_abnormal_penis_morphology1.36323545
42MP0002132_abnormal_respiratory_system1.35284370
43MP0003942_abnormal_urinary_system1.34151470
44MP0010234_abnormal_vibrissa_follicle1.31192252
45MP0010352_gastrointestinal_tract_polyps1.30397588
46MP0000003_abnormal_adipose_tissue1.28995842
47MP0005408_hypopigmentation1.27167733
48MP0003786_premature_aging1.26194318
49MP0008961_abnormal_basal_metabolism1.21877332
50MP0004197_abnormal_fetal_growth/weight/1.17181181
51MP0003172_abnormal_lysosome_physiology1.15258851
52MP0002084_abnormal_developmental_patter1.13542533
53MP0002166_altered_tumor_susceptibility1.12883457
54MP0002249_abnormal_larynx_morphology1.12816192
55MP0000313_abnormal_cell_death1.12097041
56MP0010630_abnormal_cardiac_muscle1.07830059
57MP0001915_intracranial_hemorrhage1.07243618
58MP0002085_abnormal_embryonic_tissue1.06804557
59MP0000747_muscle_weakness1.02756432
60MP0002269_muscular_atrophy1.01733776
61MP0003938_abnormal_ear_development0.98505958
62MP0003115_abnormal_respiratory_system0.97434645
63MP0003385_abnormal_body_wall0.96599260
64MP0002697_abnormal_eye_size0.94331644
65MP0005083_abnormal_biliary_tract0.92940398
66MP0004084_abnormal_cardiac_muscle0.91397663
67MP0003890_abnormal_embryonic-extraembry0.90620079
68MP0009672_abnormal_birth_weight0.90209190
69MP0000733_abnormal_muscle_development0.88420136
70MP0000383_abnormal_hair_follicle0.86852332
71MP0001545_abnormal_hematopoietic_system0.86267568
72MP0005397_hematopoietic_system_phenotyp0.86267568
73MP0009703_decreased_birth_body0.85637253
74MP0005220_abnormal_exocrine_pancreas0.84813149
75MP0005621_abnormal_cell_physiology0.84073342
76MP0006035_abnormal_mitochondrial_morpho0.83479983
77MP0002970_abnormal_white_adipose0.82196056
78MP0002019_abnormal_tumor_incidence0.82144371
79MP0000534_abnormal_ureter_morphology0.81777149
80MP0000358_abnormal_cell_content/0.81304078
81MP0002092_abnormal_eye_morphology0.80848829
82MP0005375_adipose_tissue_phenotype0.78913105
83MP0003221_abnormal_cardiomyocyte_apopto0.78574549
84MP0003937_abnormal_limbs/digits/tail_de0.78335996
85MP0010678_abnormal_skin_adnexa0.78143777
86MP0005384_cellular_phenotype0.77941938
87MP0000678_abnormal_parathyroid_gland0.77781539
88MP0000566_synostosis0.75640136
89MP0004087_abnormal_muscle_fiber0.75063298
90MP0002108_abnormal_muscle_morphology0.74317136
91MP0001849_ear_inflammation0.73952132
92MP0009115_abnormal_fat_cell0.72449859
93MP0000609_abnormal_liver_physiology0.72269480
94MP0000598_abnormal_liver_morphology0.71960238
95MP0001348_abnormal_lacrimal_gland0.71874259
96MP0000759_abnormal_skeletal_muscle0.71622190
97MP0003943_abnormal_hepatobiliary_system0.70913694
98MP0004036_abnormal_muscle_relaxation0.70077489
99MP0005666_abnormal_adipose_tissue0.69657229
100MP0000703_abnormal_thymus_morphology0.68485739

Predicted human phenotypes

RankGene SetZ-score
1Dysmetric saccades (HP:0000641)3.79674484
2Chromsome breakage (HP:0040012)3.73342707
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34783043
4Poikiloderma (HP:0001029)3.07397437
5Acanthocytosis (HP:0001927)2.98452661
6Deep venous thrombosis (HP:0002625)2.96768970
7Reticulocytosis (HP:0001923)2.91158071
8Abnormality of the fingertips (HP:0001211)2.81705206
9Right ventricular cardiomyopathy (HP:0011663)2.78668943
10Sparse lateral eyebrow (HP:0005338)2.75979952
11Ulnar bowing (HP:0003031)2.71651621
12Microvesicular hepatic steatosis (HP:0001414)2.67118510
13Septate vagina (HP:0001153)2.64550389
14Overlapping toe (HP:0001845)2.63752383
15Asymmetry of the thorax (HP:0001555)2.56908911
16Ankyloglossia (HP:0010296)2.51020134
17Broad palm (HP:0001169)2.50034850
18Abnormality of reticulocytes (HP:0004312)2.49404709
19Abnormality of homocysteine metabolism (HP:0010919)2.48873622
20Homocystinuria (HP:0002156)2.48873622
21Acute myeloid leukemia (HP:0004808)2.43579680
22Flat acetabular roof (HP:0003180)2.41980009
23Deviation of the thumb (HP:0009603)2.41612675
24Proximal placement of thumb (HP:0009623)2.37446499
25High anterior hairline (HP:0009890)2.36790210
26Deep palmar crease (HP:0006191)2.30559702
27Progressive external ophthalmoplegia (HP:0000590)2.30463395
28Deep philtrum (HP:0002002)2.29362430
29Capillary hemangiomas (HP:0005306)2.28246908
3011 pairs of ribs (HP:0000878)2.28000576
31Heterotopia (HP:0002282)2.26936555
32Cholecystitis (HP:0001082)2.26317337
33Abnormal gallbladder physiology (HP:0012438)2.26317337
34Long eyelashes (HP:0000527)2.25536330
35Birth length less than 3rd percentile (HP:0003561)2.24987517
36Abnormality of cochlea (HP:0000375)2.23214642
37Limited elbow extension (HP:0001377)2.21211949
38Hyperacusis (HP:0010780)2.18881393
39Abnormality of the intrinsic pathway (HP:0010989)2.16076209
40Entropion (HP:0000621)2.09921909
41Self-mutilation (HP:0000742)2.09331207
42Colitis (HP:0002583)2.06297646
43Progressive muscle weakness (HP:0003323)2.06112049
44Decreased lacrimation (HP:0000633)2.04340889
45Hypobetalipoproteinemia (HP:0003563)1.99810871
46Sandal gap (HP:0001852)1.97758612
47Anal stenosis (HP:0002025)1.96149090
48Missing ribs (HP:0000921)1.94609089
49Pancreatic islet-cell hyperplasia (HP:0004510)1.93827735
50Poikilocytosis (HP:0004447)1.93482877
51Increased nuchal translucency (HP:0010880)1.93475653
52Prolonged partial thromboplastin time (HP:0003645)1.93266419
53Abnormality of the thoracic spine (HP:0100711)1.92602993
54Dislocated radial head (HP:0003083)1.91127056
55Abnormal foot bone ossification (HP:0010675)1.89804966
56Prominent nose (HP:0000448)1.89476267
57Abnormality of the calcaneus (HP:0008364)1.88618538
58Thoracic kyphosis (HP:0002942)1.87827001
59Obsessive-compulsive behavior (HP:0000722)1.85972228
60Abnormality of oral frenula (HP:0000190)1.85365726
61Duplication of thumb phalanx (HP:0009942)1.82845812
62Centrally nucleated skeletal muscle fibers (HP:0003687)1.82792296
63Truncus arteriosus (HP:0001660)1.81989756
64Abnormality of chromosome stability (HP:0003220)1.81175627
65Submucous cleft hard palate (HP:0000176)1.79418661
66Termporal pattern (HP:0011008)1.79083271
67Insidious onset (HP:0003587)1.79083271
68Facial hemangioma (HP:0000329)1.78686276
69Absent radius (HP:0003974)1.78470361
70Cafe-au-lait spot (HP:0000957)1.78237274
71Small epiphyses (HP:0010585)1.77794769
72Abnormality of the radial head (HP:0003995)1.77723873
73Anteriorly placed anus (HP:0001545)1.77419469
74Hemorrhage of the eye (HP:0011885)1.76697512
75Bowel incontinence (HP:0002607)1.76565125
76Seborrheic dermatitis (HP:0001051)1.75726034
77Alacrima (HP:0000522)1.75663200
78Cerebral aneurysm (HP:0004944)1.74740968
79Abnormality of the columella (HP:0009929)1.72792062
80Low anterior hairline (HP:0000294)1.72773418
81Hypoparathyroidism (HP:0000829)1.72008679
82Tapered finger (HP:0001182)1.70800760
83Broad alveolar ridges (HP:0000187)1.70158392
84Myelodysplasia (HP:0002863)1.69617691
85Macroorchidism (HP:0000053)1.69258755
86Increased number of teeth (HP:0011069)1.68951976
87Premature skin wrinkling (HP:0100678)1.68719750
88Atelectasis (HP:0100750)1.67237802
89Bifid scrotum (HP:0000048)1.67085931
90Squamous cell carcinoma (HP:0002860)1.66779305
91Nasolacrimal duct obstruction (HP:0000579)1.66416656
92Abnormally folded helix (HP:0008544)1.65674147
93Disproportionate tall stature (HP:0001519)1.64481411
94Abnormality of the common coagulation pathway (HP:0010990)1.64290345
95Relative macrocephaly (HP:0004482)1.63328936
96Broad face (HP:0000283)1.63318223
97Orthostatic hypotension (HP:0001278)1.63289878
98Abnormal large intestine physiology (HP:0012700)1.63262268
99Biconcave vertebral bodies (HP:0004586)1.62538270
100Premature ovarian failure (HP:0008209)1.62202446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.08234089
2EEF2K3.98928128
3ICK3.51605340
4TRIB33.36912250
5NEK22.85446300
6BRD42.23869273
7MAP3K102.12396823
8AKT32.11374812
9CAMK1G1.95891751
10MST1R1.92553800
11IRAK31.87217953
12SCYL21.81308725
13CDC71.78288584
14SRPK11.76720596
15RPS6KB21.75810050
16EIF2AK11.67096819
17LATS11.63625753
18PKN21.62196207
19CAMK1D1.54101586
20SMG11.47916611
21SIK11.47036628
22RIPK41.43972715
23MTOR1.41808834
24KSR21.30509240
25NME21.28259453
26FGFR41.26689275
27TTK1.24912026
28WNK41.22352573
29WNK11.18190863
30CDK41.18035464
31MAPK111.17358663
32PNCK1.16581725
33LATS21.13737516
34CDK71.08869053
35CLK11.08741407
36CHEK11.04647589
37ATR1.03193643
38ERN11.03140954
39RIPK11.02352758
40BRSK21.02052588
41SIK21.01891233
42MARK31.01144455
43BMPR20.98651654
44CDK60.96784328
45FGFR20.95762204
46MAP3K130.89044131
47MAP2K30.88890174
48BLK0.86279758
49PBK0.83410290
50CHEK20.83360613
51RPS6KA40.83003432
52MAP3K70.82716101
53PAK20.81030652
54PRPF4B0.79414135
55PDGFRA0.75423679
56CDK20.75103314
57CDK80.74240293
58FGFR30.73352115
59CDK10.72569045
60PDK20.71535770
61ATM0.69727743
62SGK30.69427495
63AURKB0.66213182
64TRPM70.65789285
65RAF10.65610851
66RPS6KB10.64987788
67MAPK150.64909302
68MAP3K80.64378986
69WEE10.64305747
70MAP3K20.62702370
71RET0.62238581
72MAP3K60.61798810
73MELK0.59881748
74SGK20.57401389
75CDK30.57224219
76PINK10.57148117
77CDC42BPA0.56813195
78AKT20.55384503
79BRSK10.53789761
80MAPK100.52819700
81PRKAA20.52753728
82FGFR10.52349535
83ALK0.52190986
84SGK4940.50516388
85SGK2230.50516388
86PDPK10.50047136
87PLK40.49894211
88MAP3K140.48310226
89MAPK140.47020609
90NEK10.45692198
91BMX0.45640216
92EIF2AK30.43843831
93TSSK60.43018583
94AKT10.42728388
95PRKAA10.42595954
96NEK60.41662581
97MKNK10.38891873
98GSK3B0.38838206
99IRAK20.38106726
100PASK0.36691784

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.08470220
2DNA replication_Homo sapiens_hsa030302.72240851
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.58924172
4One carbon pool by folate_Homo sapiens_hsa006702.55328763
5mRNA surveillance pathway_Homo sapiens_hsa030152.45453200
6Cell cycle_Homo sapiens_hsa041102.08726467
7RNA transport_Homo sapiens_hsa030132.07510577
8Chronic myeloid leukemia_Homo sapiens_hsa052202.05379103
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90825335
10Lysine degradation_Homo sapiens_hsa003101.89280048
11Fructose and mannose metabolism_Homo sapiens_hsa000511.86481518
12Non-homologous end-joining_Homo sapiens_hsa034501.86093536
13Non-small cell lung cancer_Homo sapiens_hsa052231.83962645
14Spliceosome_Homo sapiens_hsa030401.83062478
15mTOR signaling pathway_Homo sapiens_hsa041501.68180515
16Fanconi anemia pathway_Homo sapiens_hsa034601.61214890
17Central carbon metabolism in cancer_Homo sapiens_hsa052301.60242988
18Pancreatic cancer_Homo sapiens_hsa052121.59817310
19Biosynthesis of amino acids_Homo sapiens_hsa012301.52850242
20Other glycan degradation_Homo sapiens_hsa005111.48376840
21Nucleotide excision repair_Homo sapiens_hsa034201.46805012
22Acute myeloid leukemia_Homo sapiens_hsa052211.45864140
23Mismatch repair_Homo sapiens_hsa034301.41807418
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40583225
25Thyroid cancer_Homo sapiens_hsa052161.40020820
26Pentose phosphate pathway_Homo sapiens_hsa000301.36720923
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29633667
28Prostate cancer_Homo sapiens_hsa052151.29389690
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27979014
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25559044
31Homologous recombination_Homo sapiens_hsa034401.21249019
32Small cell lung cancer_Homo sapiens_hsa052221.21004980
33Arginine biosynthesis_Homo sapiens_hsa002201.20549258
34Bladder cancer_Homo sapiens_hsa052191.19920412
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17480348
36MicroRNAs in cancer_Homo sapiens_hsa052061.15057971
37Renal cell carcinoma_Homo sapiens_hsa052111.14767945
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13654249
39B cell receptor signaling pathway_Homo sapiens_hsa046621.12043760
40Base excision repair_Homo sapiens_hsa034101.11395802
41Insulin signaling pathway_Homo sapiens_hsa049101.10657588
42Fatty acid biosynthesis_Homo sapiens_hsa000611.09478907
43Sulfur relay system_Homo sapiens_hsa041221.08093783
44Carbon metabolism_Homo sapiens_hsa012001.05616292
45Viral carcinogenesis_Homo sapiens_hsa052031.04890284
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04158674
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00992191
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99829140
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97664558
50AMPK signaling pathway_Homo sapiens_hsa041520.97153241
51HIF-1 signaling pathway_Homo sapiens_hsa040660.95824621
52Hepatitis B_Homo sapiens_hsa051610.94760171
53Endometrial cancer_Homo sapiens_hsa052130.94488209
54Glioma_Homo sapiens_hsa052140.94309889
55Colorectal cancer_Homo sapiens_hsa052100.92975314
56ErbB signaling pathway_Homo sapiens_hsa040120.90456412
57FoxO signaling pathway_Homo sapiens_hsa040680.87905054
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81606854
59Insulin resistance_Homo sapiens_hsa049310.79907157
60Complement and coagulation cascades_Homo sapiens_hsa046100.79541684
61Pyruvate metabolism_Homo sapiens_hsa006200.77702746
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77123487
63VEGF signaling pathway_Homo sapiens_hsa043700.76934303
64Selenocompound metabolism_Homo sapiens_hsa004500.76141983
65Type II diabetes mellitus_Homo sapiens_hsa049300.75513302
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72526642
67Inositol phosphate metabolism_Homo sapiens_hsa005620.72418453
68N-Glycan biosynthesis_Homo sapiens_hsa005100.72049233
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71988270
70Herpes simplex infection_Homo sapiens_hsa051680.67806650
71Adherens junction_Homo sapiens_hsa045200.66544268
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65733667
73TGF-beta signaling pathway_Homo sapiens_hsa043500.65682171
74HTLV-I infection_Homo sapiens_hsa051660.65216260
75Choline metabolism in cancer_Homo sapiens_hsa052310.64847741
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.60446413
77ABC transporters_Homo sapiens_hsa020100.60156426
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58382244
79Oocyte meiosis_Homo sapiens_hsa041140.56477703
80Apoptosis_Homo sapiens_hsa042100.55659635
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.53447594
82Basal transcription factors_Homo sapiens_hsa030220.51566128
83Glucagon signaling pathway_Homo sapiens_hsa049220.50743070
84Notch signaling pathway_Homo sapiens_hsa043300.50487070
85Epstein-Barr virus infection_Homo sapiens_hsa051690.50235941
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49722571
87GnRH signaling pathway_Homo sapiens_hsa049120.48679935
88Proteoglycans in cancer_Homo sapiens_hsa052050.46529012
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46186174
90Systemic lupus erythematosus_Homo sapiens_hsa053220.45994587
91RNA degradation_Homo sapiens_hsa030180.45131371
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43658860
93Thyroid hormone synthesis_Homo sapiens_hsa049180.43227272
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.40706553
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.40423261
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40035928
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37997559
98Alcoholism_Homo sapiens_hsa050340.37750860
99Melanoma_Homo sapiens_hsa052180.37644370
100Influenza A_Homo sapiens_hsa051640.36175646

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