SLC16A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)8.60542977
2drug transmembrane transport (GO:0006855)8.23462421
3organic cation transport (GO:0015695)7.00946054
4drug transport (GO:0015893)6.96931864
5lysine catabolic process (GO:0006554)6.83815256
6lysine metabolic process (GO:0006553)6.83815256
7lymph vessel development (GO:0001945)6.75022317
8aminoglycoside antibiotic metabolic process (GO:0030647)6.38571376
9phosphate ion transport (GO:0006817)5.81555394
10quaternary ammonium group transport (GO:0015697)5.79640544
11metanephric tubule development (GO:0072170)5.73301520
12metanephric nephron tubule development (GO:0072234)5.73301520
13metanephric nephron epithelium development (GO:0072243)5.50924833
14surfactant homeostasis (GO:0043129)5.27562820
15metanephric epithelium development (GO:0072207)5.26905309
16excretion (GO:0007588)5.09117188
17response to mercury ion (GO:0046689)5.03411753
18renal absorption (GO:0070293)4.98516071
19phosphate ion transmembrane transport (GO:0035435)4.92843758
20cysteine metabolic process (GO:0006534)4.89660763
21endothelium development (GO:0003158)4.55844894
22glyoxylate metabolic process (GO:0046487)4.55384153
23peptidyl-tyrosine autophosphorylation (GO:0038083)4.48717987
24nephron tubule development (GO:0072080)4.47902975
25short-chain fatty acid metabolic process (GO:0046459)4.44197065
26toxin transport (GO:1901998)4.41575742
27polyol transport (GO:0015791)4.40440645
28modified amino acid transport (GO:0072337)4.34816518
29indole-containing compound catabolic process (GO:0042436)4.32464424
30indolalkylamine catabolic process (GO:0046218)4.32464424
31tryptophan catabolic process (GO:0006569)4.32464424
32sodium-independent organic anion transport (GO:0043252)4.30908255
33chemical homeostasis within a tissue (GO:0048875)4.30603301
34behavioral response to nicotine (GO:0035095)4.26753553
35nephron epithelium development (GO:0072009)4.18789046
36L-ascorbic acid metabolic process (GO:0019852)4.13675167
37vascular endothelial growth factor signaling pathway (GO:0038084)4.08614330
38aspartate family amino acid catabolic process (GO:0009068)4.06835792
39tryptophan metabolic process (GO:0006568)4.01650906
40homocysteine metabolic process (GO:0050667)4.00428561
41vitamin transmembrane transport (GO:0035461)3.99817794
42renal tubule development (GO:0061326)3.89994400
43valine metabolic process (GO:0006573)3.89158264
44carnitine transport (GO:0015879)3.83334079
45amino-acid betaine transport (GO:0015838)3.83334079
46proline metabolic process (GO:0006560)3.81371929
47protein K11-linked deubiquitination (GO:0035871)3.78645862
48aromatic amino acid family catabolic process (GO:0009074)3.78082238
49response to phenylpropanoid (GO:0080184)3.75900140
502-oxoglutarate metabolic process (GO:0006103)3.71841834
51drug catabolic process (GO:0042737)3.69959788
52vitamin D metabolic process (GO:0042359)3.68857190
53vitamin transport (GO:0051180)3.66628049
54regulation of hippo signaling (GO:0035330)3.62263346
55nonribosomal peptide biosynthetic process (GO:0019184)3.61621594
56Notch signaling involved in heart development (GO:0061314)3.60745678
57tricarboxylic acid metabolic process (GO:0072350)3.49832699
58glutamate metabolic process (GO:0006536)3.48142691
59branched-chain amino acid metabolic process (GO:0009081)3.46920606
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.41389304
61kynurenine metabolic process (GO:0070189)3.38622613
62amino-acid betaine metabolic process (GO:0006577)3.35021255
63exogenous drug catabolic process (GO:0042738)3.34468601
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33105210
65fucose catabolic process (GO:0019317)3.27883900
66L-fucose metabolic process (GO:0042354)3.27883900
67L-fucose catabolic process (GO:0042355)3.27883900
68sulfur compound transport (GO:0072348)3.20184968
69carnitine metabolic process (GO:0009437)3.15250866
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.08214920
71fatty acid beta-oxidation (GO:0006635)3.07713955
72phosphate ion homeostasis (GO:0055062)3.07705167
73trivalent inorganic anion homeostasis (GO:0072506)3.07705167
74amine catabolic process (GO:0009310)3.07587288
75cellular biogenic amine catabolic process (GO:0042402)3.07587288
76acetyl-CoA metabolic process (GO:0006084)3.06568234
77glutathione biosynthetic process (GO:0006750)3.04289008
78nephron tubule morphogenesis (GO:0072078)3.03873244
79nephron epithelium morphogenesis (GO:0072088)3.03873244
80kidney mesenchyme development (GO:0072074)3.02829283
81vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.99139298
82renal tubule morphogenesis (GO:0061333)2.98330673
83negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.97564043
84mesenchymal-epithelial cell signaling (GO:0060638)2.95729492
85fatty acid oxidation (GO:0019395)2.89395152
86oligosaccharide catabolic process (GO:0009313)2.89191865
87serine family amino acid catabolic process (GO:0009071)2.87474755
88endothelial cell morphogenesis (GO:0001886)2.87366768
89retina vasculature morphogenesis in camera-type eye (GO:0061299)2.87340187
90hyperosmotic salinity response (GO:0042538)2.87288797
91cornea development in camera-type eye (GO:0061303)2.86127196
92water-soluble vitamin biosynthetic process (GO:0042364)2.86114835
93pericardium development (GO:0060039)2.85358418
94response to pheromone (GO:0019236)2.85141545
95indolalkylamine metabolic process (GO:0006586)2.85137815
96cellular modified amino acid catabolic process (GO:0042219)2.85056347
97peptide catabolic process (GO:0043171)2.83860809
98flavonoid metabolic process (GO:0009812)2.83658319
99lipid oxidation (GO:0034440)2.83534820
100L-phenylalanine catabolic process (GO:0006559)2.80306760
101erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.80306760
102cilium morphogenesis (GO:0060271)2.80155825
103L-phenylalanine metabolic process (GO:0006558)2.79337731
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.79337731
105daunorubicin metabolic process (GO:0044597)2.78853376
106polyketide metabolic process (GO:0030638)2.78853376
107doxorubicin metabolic process (GO:0044598)2.78853376
108sulfation (GO:0051923)2.78754470
109estrogen biosynthetic process (GO:0006703)2.77259691
110response to growth hormone (GO:0060416)2.76471795
111transepithelial transport (GO:0070633)2.75857481
112kidney morphogenesis (GO:0060993)2.75078886
113regulation of steroid hormone biosynthetic process (GO:0090030)2.74940995
114retinal metabolic process (GO:0042574)2.74579021
115transcytosis (GO:0045056)2.74263823
116nephron tubule formation (GO:0072079)2.74244324
117glomerular filtration (GO:0003094)2.73321528
118protein-cofactor linkage (GO:0018065)2.73148789
119indole-containing compound metabolic process (GO:0042430)2.73035725
120regulation of apoptotic process involved in morphogenesis (GO:1902337)2.72934945
121insulin-like growth factor receptor signaling pathway (GO:0048009)2.72450211
122nonmotile primary cilium assembly (GO:0035058)2.72202366
123cellular ketone body metabolic process (GO:0046950)2.71655603
124serine family amino acid metabolic process (GO:0009069)2.70341026
125thyroid hormone metabolic process (GO:0042403)2.70215450
126histamine transport (GO:0051608)2.69531747
127cellular glucuronidation (GO:0052695)2.68285847
128negative regulation of axon extension involved in axon guidance (GO:0048843)2.65565992
129ketone body metabolic process (GO:1902224)2.63984414
130protein localization to cilium (GO:0061512)2.63396425
131oxidative demethylation (GO:0070989)2.61110112
132glucuronate metabolic process (GO:0019585)2.60974587
133uronic acid metabolic process (GO:0006063)2.60974587
134negative regulation of axon guidance (GO:1902668)2.59966214
135gamma-aminobutyric acid transport (GO:0015812)2.57437459
136arginine metabolic process (GO:0006525)2.57230426
137platelet dense granule organization (GO:0060155)2.54311447
138coenzyme catabolic process (GO:0009109)2.53945069
139detection of light stimulus involved in visual perception (GO:0050908)2.51145831
140detection of light stimulus involved in sensory perception (GO:0050962)2.51145831
141nucleotide transmembrane transport (GO:1901679)2.51025607
142epithelial cilium movement (GO:0003351)2.50148037
143positive regulation of fatty acid transport (GO:2000193)2.48960913
144preassembly of GPI anchor in ER membrane (GO:0016254)2.48373307
145dopamine transport (GO:0015872)2.45101727
146phosphatidylinositol acyl-chain remodeling (GO:0036149)2.44816368
147keratinocyte development (GO:0003334)2.44797472
148purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.44715852
1493-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.44715852
150detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42603409
151negative regulation of mast cell activation (GO:0033004)2.41768839
152inner ear receptor stereocilium organization (GO:0060122)2.41289456
153positive regulation of icosanoid secretion (GO:0032305)2.40786398
154regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.39561790
155photoreceptor cell maintenance (GO:0045494)2.38704277
156reflex (GO:0060004)2.38674270
157phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.38010967
158glomerular basement membrane development (GO:0032836)2.37127055
159arginine catabolic process (GO:0006527)2.36691055
160S-adenosylmethionine metabolic process (GO:0046500)2.34554726
161drug metabolic process (GO:0017144)2.34292250
162positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.31513361
163somite development (GO:0061053)2.30679213
164cilium organization (GO:0044782)2.29676677
165intraciliary transport (GO:0042073)2.28357150
166diterpenoid biosynthetic process (GO:0016102)2.27765152
167cilium assembly (GO:0042384)2.27236396
168response to redox state (GO:0051775)2.26378210
169regulation of protein glycosylation (GO:0060049)2.26142448
170phosphatidylserine acyl-chain remodeling (GO:0036150)2.25974034
171estrogen metabolic process (GO:0008210)2.25812645
172quinone metabolic process (GO:1901661)2.24135529
173cellular response to vitamin D (GO:0071305)2.23722239
174neural tube formation (GO:0001841)2.22040994
175thyroid hormone generation (GO:0006590)2.21427274
176phenylpropanoid metabolic process (GO:0009698)2.21163882
177regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.20974598
178regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.20877812
179head development (GO:0060322)2.19880631
180regulation of glucokinase activity (GO:0033131)2.19400817
181regulation of hexokinase activity (GO:1903299)2.19400817
182nucleobase catabolic process (GO:0046113)2.19259667
183positive regulation of fatty acid oxidation (GO:0046321)2.18881065

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.96922738
2ZNF274_21170338_ChIP-Seq_K562_Hela2.84703113
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.82657581
4CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.79886526
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.66980050
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63232747
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.43970112
8VDR_22108803_ChIP-Seq_LS180_Human2.43919754
9GBX2_23144817_ChIP-Seq_PC3_Human2.39425537
10PIAS1_25552417_ChIP-Seq_VCAP_Human2.31138065
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.13558678
12* GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13228751
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10074335
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.01878081
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.00958111
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99046568
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.95050826
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.91768933
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86121720
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.84259935
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81019215
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74581110
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74087733
24EWS_26573619_Chip-Seq_HEK293_Human1.73410815
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.71787982
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68063581
27CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.67710303
28TP53_16413492_ChIP-PET_HCT116_Human1.67246665
29CJUN_26792858_Chip-Seq_BT549_Human1.66688605
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.66665894
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.66665894
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.66345663
33STAT3_23295773_ChIP-Seq_U87_Human1.66323509
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65084248
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64793547
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63933100
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63147353
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.62371851
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59935125
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59430013
41AHR_22903824_ChIP-Seq_MCF-7_Human1.57962845
42IGF1R_20145208_ChIP-Seq_DFB_Human1.57070766
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54374909
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.52778593
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.51714484
46CBP_20019798_ChIP-Seq_JUKART_Human1.51385862
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51385862
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.49620116
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48733296
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.48677056
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48346901
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47842927
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47103515
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.46505298
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.45811364
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.45167379
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44549348
58TAF15_26573619_Chip-Seq_HEK293_Human1.43791801
59TCF4_23295773_ChIP-Seq_U87_Human1.43656183
60EZH2_22144423_ChIP-Seq_EOC_Human1.43274177
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42524925
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42524925
63P300_19829295_ChIP-Seq_ESCs_Human1.41849987
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.41098077
65CLOCK_20551151_ChIP-Seq_293T_Human1.40907739
66TP53_18474530_ChIP-ChIP_U2OS_Human1.40644116
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40634972
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40613264
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40562212
70AR_21909140_ChIP-Seq_LNCAP_Human1.39191583
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38327807
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38250859
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37337503
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35483666
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35256826
76RXR_22108803_ChIP-Seq_LS180_Human1.35069447
77AR_21572438_ChIP-Seq_LNCaP_Human1.35064507
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.34560635
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34218732
80TCF4_22108803_ChIP-Seq_LS180_Human1.33933659
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33192509
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31096724
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30323950
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29170901
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28578842
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28506255
87SMAD3_21741376_ChIP-Seq_HESCs_Human1.28246291
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27686943
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27652481
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27639140
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.27460312
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27118365
93* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27082369
94* SOX2_20726797_ChIP-Seq_SW620_Human1.26658396
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.26638188
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.26081236
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23959684
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22869465
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.21332464
100TCF4_18268006_ChIP-ChIP_LS174T_Human1.21085739
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20383577
102RUNX2_22187159_ChIP-Seq_PCA_Human1.20029823
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19992545
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.19944167
105P53_22387025_ChIP-Seq_ESCs_Mouse1.19657673
106ESR1_20079471_ChIP-ChIP_T-47D_Human1.19639538
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19077029
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17783442
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16822620
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16315294
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15848760
112SOX2_19829295_ChIP-Seq_ESCs_Human1.14844703
113NANOG_19829295_ChIP-Seq_ESCs_Human1.14844703
114EZH2_27304074_Chip-Seq_ESCs_Mouse1.14038241
115BCAT_22108803_ChIP-Seq_LS180_Human1.13567377
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13481974
117ISL1_27105846_Chip-Seq_CPCs_Mouse1.12495083
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.12461541
119MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11808580
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11642983
121* SMAD4_21799915_ChIP-Seq_A2780_Human1.10772715
122VDR_24787735_ChIP-Seq_THP-1_Human1.10481461
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.08467984
124FUS_26573619_Chip-Seq_HEK293_Human1.07963994
125BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04630636
126TP53_22573176_ChIP-Seq_HFKS_Human1.03919257
127BRD4_25478319_ChIP-Seq_HGPS_Human1.03469425
128ER_23166858_ChIP-Seq_MCF-7_Human1.02632305
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02030558
130SMAD4_21741376_ChIP-Seq_EPCs_Human1.01817385
131CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01617286
132SMAD4_21741376_ChIP-Seq_HESCs_Human1.01311221
133TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01091962
134TBL1_22424771_ChIP-Seq_293T_Human1.00932531
135SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00769934
136FLI1_21867929_ChIP-Seq_TH2_Mouse1.00625745
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00523194
138ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00471830
139FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99864896
140FOXA1_25329375_ChIP-Seq_VCAP_Human0.99864896
141GATA4_25053715_ChIP-Seq_YYC3_Human0.99661861
142CDX2_22108803_ChIP-Seq_LS180_Human0.99585306
143OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99262643
144TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99149078
145SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98938767
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98880279
147SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97973249
148FOXA2_19822575_ChIP-Seq_HepG2_Human0.97507547
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97302239
150JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96596243
151AR_25329375_ChIP-Seq_VCAP_Human0.96296683
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96099939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.43241249
2MP0004043_abnormal_pH_regulation4.78199444
3MP0005332_abnormal_amino_acid3.69971259
4MP0003195_calcinosis3.54439393
5MP0004272_abnormal_basement_membrane3.45331282
6MP0004019_abnormal_vitamin_homeostasis3.41635204
7MP0001879_abnormal_lymphatic_vessel3.40402959
8MP0002138_abnormal_hepatobiliary_system3.03843056
9MP0003878_abnormal_ear_physiology2.95147735
10MP0005377_hearing/vestibular/ear_phenot2.95147735
11MP0010386_abnormal_urinary_bladder2.88486112
12MP0001958_emphysema2.87846859
13MP0009643_abnormal_urine_homeostasis2.84979039
14MP0002139_abnormal_hepatobiliary_system2.62580812
15MP0005167_abnormal_blood-brain_barrier2.50142259
16MP0001765_abnormal_ion_homeostasis2.48295803
17MP0001756_abnormal_urination2.42806341
18MP0002136_abnormal_kidney_physiology2.33822922
19MP0006054_spinal_hemorrhage2.28284461
20MP0005084_abnormal_gallbladder_morpholo2.27759271
21MP0004147_increased_porphyrin_level2.24758196
22MP0003950_abnormal_plasma_membrane2.14696467
23MP0005636_abnormal_mineral_homeostasis1.97623600
24MP0003252_abnormal_bile_duct1.92465259
25MP0003136_yellow_coat_color1.92121843
26MP0000372_irregular_coat_pigmentation1.90518567
27MP0000427_abnormal_hair_cycle1.88329553
28MP0005551_abnormal_eye_electrophysiolog1.84381588
29MP0005174_abnormal_tail_pigmentation1.71086094
30MP0002089_abnormal_postnatal_growth/wei1.70719431
31MP0002896_abnormal_bone_mineralization1.68566448
32MP0008875_abnormal_xenobiotic_pharmacok1.66370182
33MP0001986_abnormal_taste_sensitivity1.60191766
34MP0002837_dystrophic_cardiac_calcinosis1.55998864
35MP0006072_abnormal_retinal_apoptosis1.50047347
36MP0003279_aneurysm1.47807702
37MP0010368_abnormal_lymphatic_system1.46997670
38MP0004484_altered_response_of1.44992050
39MP0009780_abnormal_chondrocyte_physiolo1.44971958
40MP0002282_abnormal_trachea_morphology1.44640380
41MP0004142_abnormal_muscle_tone1.44133335
42MP0005253_abnormal_eye_physiology1.40409886
43MP0009384_cardiac_valve_regurgitation1.39884878
44MP0005171_absent_coat_pigmentation1.38752654
45MP0005275_abnormal_skin_tensile1.36580110
46MP0005623_abnormal_meninges_morphology1.34682911
47MP0002928_abnormal_bile_duct1.34283913
48MP0005408_hypopigmentation1.33490109
49MP0002249_abnormal_larynx_morphology1.32686789
50MP0005503_abnormal_tendon_morphology1.32534433
51MP0000538_abnormal_urinary_bladder1.31891971
52MP0002234_abnormal_pharynx_morphology1.29876864
53MP0008961_abnormal_basal_metabolism1.29769763
54MP0004133_heterotaxia1.29572385
55MP0001485_abnormal_pinna_reflex1.28826295
56MP0000163_abnormal_cartilage_morphology1.28067811
57MP0009379_abnormal_foot_pigmentation1.27684874
58MP0005257_abnormal_intraocular_pressure1.26467075
59MP0003011_delayed_dark_adaptation1.26156433
60MP0003937_abnormal_limbs/digits/tail_de1.25963840
61MP0002108_abnormal_muscle_morphology1.22872876
62MP0005085_abnormal_gallbladder_physiolo1.22570412
63MP0004885_abnormal_endolymph1.21301296
64MP0002168_other_aberrant_phenotype1.19068905
65MP0002653_abnormal_ependyma_morphology1.18952978
66MP0003646_muscle_fatigue1.17227236
67MP0003300_gastrointestinal_ulcer1.16756999
68MP0005365_abnormal_bile_salt1.16233667
69MP0002009_preneoplasia1.15970186
70MP0000762_abnormal_tongue_morphology1.15409827
71MP0006276_abnormal_autonomic_nervous1.15192576
72MP0000383_abnormal_hair_follicle1.14153681
73MP0009250_abnormal_appendicular_skeleto1.13989281
74MP0000230_abnormal_systemic_arterial1.12380874
75MP0002115_abnormal_skeleton_extremities1.09533587
76MP0005195_abnormal_posterior_eye1.04033587
77MP0001324_abnormal_eye_pigmentation1.03275289
78MP0003283_abnormal_digestive_organ1.02244284
79MP0003755_abnormal_palate_morphology1.02049345
80MP0002938_white_spotting1.00861775
81MP0008789_abnormal_olfactory_epithelium1.00754116
82MP0001968_abnormal_touch/_nociception0.98729601
83MP0005197_abnormal_uvea_morphology0.98630423
84MP0001270_distended_abdomen0.97809162
85MP0006292_abnormal_olfactory_placode0.96930325
86MP0005165_increased_susceptibility_to0.96896863
87MP0003186_abnormal_redox_activity0.95832080
88MP0001501_abnormal_sleep_pattern0.95473360
89MP0000371_diluted_coat_color0.95011110
90MP0010234_abnormal_vibrissa_follicle0.94948803
91MP0001177_atelectasis0.94372304
92MP0005389_reproductive_system_phenotype0.93424698
93MP0002233_abnormal_nose_morphology0.92445247
94MP0010329_abnormal_lipoprotein_level0.90128214
95MP0002102_abnormal_ear_morphology0.89796207
96MP0002095_abnormal_skin_pigmentation0.89727735
97MP0002638_abnormal_pupillary_reflex0.89163815
98MP0008872_abnormal_physiological_respon0.88946303
99MP0002098_abnormal_vibrissa_morphology0.88001027
100MP0005595_abnormal_vascular_smooth0.87853083
101MP0001666_abnormal_nutrient_absorption0.87443012
102MP0004134_abnormal_chest_morphology0.87239292
103MP0003638_abnormal_response/metabolism_0.85204314
104MP0002135_abnormal_kidney_morphology0.85051261
105MP0001299_abnormal_eye_distance/0.84998825
106MP0000639_abnormal_adrenal_gland0.84553169
107MP0009278_abnormal_bone_marrow0.84527336
108MP0000647_abnormal_sebaceous_gland0.84486056
109MP0000026_abnormal_inner_ear0.83792136
110MP0008438_abnormal_cutaneous_collagen0.83500135
111MP0005409_darkened_coat_color0.83455708
112MP0000534_abnormal_ureter_morphology0.82607909
113MP0003943_abnormal_hepatobiliary_system0.82564205
114MP0001905_abnormal_dopamine_level0.82521986
115MP0000569_abnormal_digit_pigmentation0.81907470
116MP0002557_abnormal_social/conspecific_i0.81883187
117MP0002113_abnormal_skeleton_development0.81437687
118MP0002295_abnormal_pulmonary_circulatio0.79540179
119MP0004924_abnormal_behavior0.79394275
120MP0005386_behavior/neurological_phenoty0.79394275
121MP0000778_abnormal_nervous_system0.79315790
122MP0002160_abnormal_reproductive_system0.78565992
123MP0004085_abnormal_heartbeat0.77311896
124MP0000015_abnormal_ear_pigmentation0.77294393
125MP0000049_abnormal_middle_ear0.76917636
126MP0002075_abnormal_coat/hair_pigmentati0.76851498
127MP0005395_other_phenotype0.75590624
128MP0003936_abnormal_reproductive_system0.75505125
129MP0010678_abnormal_skin_adnexa0.75322955
130MP0002109_abnormal_limb_morphology0.75128197
131MP0003941_abnormal_skin_development0.74922182
132MP0002876_abnormal_thyroid_physiology0.72371666
133MP0005330_cardiomyopathy0.70421103
134MP0003795_abnormal_bone_structure0.70401726
135MP0001188_hyperpigmentation0.70043307
136MP0008775_abnormal_heart_ventricle0.68273412
137MP0005584_abnormal_enzyme/coenzyme_acti0.67604041
138MP0005670_abnormal_white_adipose0.62236458
139MP0002998_abnormal_bone_remodeling0.61382183
140MP0003942_abnormal_urinary_system0.60862408
141MP0009697_abnormal_copulation0.60512385
142MP0005508_abnormal_skeleton_morphology0.59940638
143MP0002933_joint_inflammation0.58904531
144MP0001915_intracranial_hemorrhage0.58774729
145MP0000432_abnormal_head_morphology0.58056671
146MP0003935_abnormal_craniofacial_develop0.57220165
147MP0002133_abnormal_respiratory_system0.56955685
148MP0005388_respiratory_system_phenotype0.56955685
149MP0003091_abnormal_cell_migration0.56521241
150MP0006138_congestive_heart_failure0.56343097
151MP0000767_abnormal_smooth_muscle0.55870174
152MP0005319_abnormal_enzyme/_coenzyme0.55852287
153MP0000377_abnormal_hair_follicle0.55617910
154MP0001784_abnormal_fluid_regulation0.55343434
155MP0002127_abnormal_cardiovascular_syste0.54724762
156MP0009764_decreased_sensitivity_to0.54688913

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)7.06616146
2Increased circulating renin level (HP:0000848)6.84267704
3Hypomagnesemia (HP:0002917)6.67112417
4Hypokalemic alkalosis (HP:0001949)6.50143068
5Polyuria (HP:0000103)6.22856721
6Abnormal urine output (HP:0012590)5.86179734
7Hyperactive renin-angiotensin system (HP:0000841)5.81770880
8Abnormality of chloride homeostasis (HP:0011422)5.45845047
9Polydipsia (HP:0001959)5.42772552
10Abnormal drinking behavior (HP:0030082)5.42772552
11Abnormality of magnesium homeostasis (HP:0004921)5.35447910
12Abnormality of renal excretion (HP:0011036)5.32916738
13Gout (HP:0001997)5.20949935
14Tetany (HP:0001281)5.00308416
15Hyperuricemia (HP:0002149)4.81005233
16Increased purine levels (HP:0004368)4.81005233
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.58833383
18Proximal tubulopathy (HP:0000114)4.38247141
19Pancreatic cysts (HP:0001737)4.05643252
20Hyperaldosteronism (HP:0000859)4.03809724
21Renal salt wasting (HP:0000127)4.03356253
22Abnormality of renin-angiotensin system (HP:0000847)3.96471730
23Delayed epiphyseal ossification (HP:0002663)3.87450490
24Pancreatic fibrosis (HP:0100732)3.83396557
25Alkalosis (HP:0001948)3.80593854
26Molar tooth sign on MRI (HP:0002419)3.75707372
27Abnormality of midbrain morphology (HP:0002418)3.75707372
28Abnormality of purine metabolism (HP:0004352)3.70393029
29Renal tubular acidosis (HP:0001947)3.55814656
30Epiphyseal dysplasia (HP:0002656)3.55440335
31Hyperglycinuria (HP:0003108)3.48632700
32True hermaphroditism (HP:0010459)3.46325091
33Abnormality of proline metabolism (HP:0010907)3.42809935
34Hydroxyprolinuria (HP:0003080)3.42809935
35Chorioretinal atrophy (HP:0000533)3.39935635
36Congenital stationary night blindness (HP:0007642)3.38929101
37Type II lissencephaly (HP:0007260)3.34219378
38Chronic hepatic failure (HP:0100626)3.27427971
39Hypercalciuria (HP:0002150)3.23019360
40Nephronophthisis (HP:0000090)3.17443301
41Confusion (HP:0001289)3.14000117
42Hypokalemia (HP:0002900)3.06350562
43Tubular atrophy (HP:0000092)2.97809626
44Abnormality of glycine metabolism (HP:0010895)2.96263273
45Abnormality of serine family amino acid metabolism (HP:0010894)2.96263273
46Abnormal tarsal ossification (HP:0008369)2.95989338
47Ketoacidosis (HP:0001993)2.94779101
48Keratoconus (HP:0000563)2.90810075
49Increased corneal curvature (HP:0100692)2.90810075
50Cerebellar dysplasia (HP:0007033)2.86684640
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.82924104
52Attenuation of retinal blood vessels (HP:0007843)2.79611535
53Delayed CNS myelination (HP:0002188)2.71168767
54Cystic liver disease (HP:0006706)2.70765861
55Hyperventilation (HP:0002883)2.68974613
56Neonatal short-limb short stature (HP:0008921)2.67787484
57Vitreoretinal degeneration (HP:0000655)2.62716760
58Congenital sensorineural hearing impairment (HP:0008527)2.60485740
59Abnormality of potassium homeostasis (HP:0011042)2.58596985
60Medial flaring of the eyebrow (HP:0010747)2.58310948
61Metaphyseal cupping (HP:0003021)2.57936608
62Enlarged kidneys (HP:0000105)2.48392116
63Occipital encephalocele (HP:0002085)2.44909945
64Abnormality of nucleobase metabolism (HP:0010932)2.44902567
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.43735049
66Generalized aminoaciduria (HP:0002909)2.40384240
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.40222072
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.33120017
69Lymphangioma (HP:0100764)2.28443811
70Nephrocalcinosis (HP:0000121)2.28163251
71Metaphyseal irregularity (HP:0003025)2.27592809
72Ketosis (HP:0001946)2.27450573
73Decreased circulating renin level (HP:0003351)2.24088553
74Abnormality of carpal bone ossification (HP:0006257)2.21261926
75Widely patent fontanelles and sutures (HP:0004492)2.16058363
76Hypoplastic ischia (HP:0003175)2.15390932
77Congenital hepatic fibrosis (HP:0002612)2.13321366
78Hip contracture (HP:0003273)2.13280713
79Renal cortical cysts (HP:0000803)2.12688985
80Abnormal foot bone ossification (HP:0010675)2.12544091
81Irregular epiphyses (HP:0010582)2.12246843
82Potter facies (HP:0002009)2.11398500
83Facial shape deformation (HP:0011334)2.11398500
84Glycosuria (HP:0003076)2.10715800
85Abnormality of urine glucose concentration (HP:0011016)2.10715800
86Bile duct proliferation (HP:0001408)2.07181460
87Abnormal biliary tract physiology (HP:0012439)2.07181460
88Hypoplasia of the iris (HP:0007676)2.06605200
89Stage 5 chronic kidney disease (HP:0003774)2.05002216
90Vascular calcification (HP:0004934)2.04387142
91Rickets (HP:0002748)2.03924392
92Flat acetabular roof (HP:0003180)2.03839168
93Abnormality of sulfur amino acid metabolism (HP:0004339)2.01214474
94Abnormality of fatty-acid metabolism (HP:0004359)1.99725667
95Tubulointerstitial fibrosis (HP:0005576)1.99458789
96Nephrolithiasis (HP:0000787)1.99101513
97Congenital primary aphakia (HP:0007707)1.98990678
98Nephrogenic diabetes insipidus (HP:0009806)1.98762354
99Gait imbalance (HP:0002141)1.98687721
100Chondrocalcinosis (HP:0000934)1.97789258
101Thyroid-stimulating hormone excess (HP:0002925)1.97076101
102Abnormality of the pons (HP:0007361)1.96998012
103Abolished electroretinogram (ERG) (HP:0000550)1.96951479
104Decreased central vision (HP:0007663)1.96496310
105Abnormality of the renal cortex (HP:0011035)1.96185150
106Cardiovascular calcification (HP:0011915)1.96074506
107Abnormality of Sharpey fibers (HP:0100685)1.93605798
108Abnormality of the nasal septum (HP:0000419)1.92867615
109Hypoplasia of the pons (HP:0012110)1.92200171
110Abnormal rod and cone electroretinograms (HP:0008323)1.90428506
111Abnormal hand bone ossification (HP:0010660)1.90168369
112Abnormality of the ischium (HP:0003174)1.88902071
113Short tibia (HP:0005736)1.87970325
114Mesomelia (HP:0003027)1.87883809
115Furrowed tongue (HP:0000221)1.87420572
116Postaxial foot polydactyly (HP:0001830)1.86269240
117Limited hip movement (HP:0008800)1.86107078
118Hypothermia (HP:0002045)1.85964750
119Abnormal ossification of hand bones (HP:0005921)1.85689027
120Hyperphosphaturia (HP:0003109)1.85101675
121Abnormality of sodium homeostasis (HP:0010931)1.84108372
122Cupped ribs (HP:0000887)1.83740306
123Genital tract atresia (HP:0001827)1.83608143
124Bilateral sensorineural hearing impairment (HP:0008619)1.82689898
125Choroideremia (HP:0001139)1.82351675
126Follicular hyperkeratosis (HP:0007502)1.82304432
127Dehydration (HP:0001944)1.81898271
128Abnormal urine phosphate concentration (HP:0012599)1.80701843
129Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78551242
130Hypophosphatemia (HP:0002148)1.77593368
131Fair hair (HP:0002286)1.77024776
132Concave nail (HP:0001598)1.76115021
133Vaginal atresia (HP:0000148)1.75770608
134Hyperglycinemia (HP:0002154)1.75197300
135Protuberant abdomen (HP:0001538)1.74805582
136Pendular nystagmus (HP:0012043)1.74484053
137Lissencephaly (HP:0001339)1.74276899
138Sclerocornea (HP:0000647)1.73563281
139Renal tubular dysfunction (HP:0000124)1.73347413
140Abnormality of alanine metabolism (HP:0010916)1.73016895
141Hyperalaninemia (HP:0003348)1.73016895
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73016895
143Bulbous nose (HP:0000414)1.72457425
144Tubulointerstitial abnormality (HP:0001969)1.72432335
145Aplasia/hypoplasia of the uterus (HP:0008684)1.71567844
146Abnormal vertebral ossification (HP:0100569)1.71321527
147Postaxial hand polydactyly (HP:0001162)1.70826270
148Bony spicule pigmentary retinopathy (HP:0007737)1.70220778
149Hypoplasia of the uterus (HP:0000013)1.70003035
150Aplasia/Hypoplasia of the fovea (HP:0008060)1.68860820
151Hypoplasia of the fovea (HP:0007750)1.68860820
152Metaphyseal dysplasia (HP:0100255)1.68041058
153Hypoplastic nipples (HP:0002557)1.67263273
154Vascular tortuosity (HP:0004948)1.67143734
155Enlarged epiphyses (HP:0010580)1.67084129
156Abnormal albumin level (HP:0012116)1.65239816
157Hypoalbuminemia (HP:0003073)1.65239816
158Hypoplastic labia majora (HP:0000059)1.64750754
159Albinism (HP:0001022)1.64133820
160Cervical subluxation (HP:0003308)1.64111587
161Increased number of teeth (HP:0011069)1.64064456
162Hyponatremia (HP:0002902)1.63884907
163Wide cranial sutures (HP:0010537)1.61677118
164Abnormality of the middle phalanges of the toes (HP:0010183)1.60178551
165Hypoglycemic coma (HP:0001325)1.58379143
166Abnormality of the renal medulla (HP:0100957)1.58107063
167Mild short stature (HP:0003502)1.57404721
168Abnormality of incisor morphology (HP:0011063)1.57263687
169Distal lower limb muscle weakness (HP:0009053)1.55487081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK38.10272915
2OXSR16.32190649
3WNK46.00509395
4KDR3.68233796
5STK393.26207758
6ADRBK22.85667295
7TIE12.59067622
8PDK22.14960128
9PINK11.97293423
10TGFBR21.89033257
11STK38L1.78204331
12PTK2B1.73021998
13MAP4K21.72506893
14TLK11.68061252
15WNK11.61980921
16INSRR1.61181667
17ADRBK11.51754096
18SGK4941.49600499
19SGK2231.49600499
20DDR21.45518820
21MAP3K121.37723188
22TAOK31.32692886
23AKT31.29809743
24ZAK1.28800788
25NUAK11.26727141
26MST41.26622781
27NEK11.26357464
28TRIM281.18576054
29BRSK21.15672541
30MAPK131.14730478
31SGK21.10294636
32NTRK31.07637677
33FRK1.04828016
34CAMK1G1.00552985
35GRK10.97492259
36ERBB30.97111735
37GSK3A0.96472061
38NLK0.94238773
39PRKAA20.94040496
40TGFBR10.93825753
41PRKG20.91873274
42DAPK20.91622548
43CAMK1D0.90139811
44NEK60.88363910
45CAMKK20.86903759
46EPHA30.86099183
47LIMK10.84806658
48PIK3CA0.83592271
49PTK20.83325845
50FLT30.81675899
51PAK40.76884701
52LMTK20.75919184
53DMPK0.75671023
54MYLK0.74177972
55PIK3CG0.73630128
56PDK40.73522904
57PDK30.73522904
58PNCK0.73335604
59MKNK20.72422408
60EPHB20.72108330
61MAPKAPK30.71205889
62MST1R0.70370384
63MAP3K40.70274337
64SGK10.69857280
65SGK30.69306598
66PRKCG0.68075910
67RIPK10.67661005
68MAP3K30.67539174
69MAP3K140.67427822
70PTK60.67145693
71ACVR1B0.65123216
72PRKD20.65103541
73PHKG10.64786655
74PHKG20.64786655
75IGF1R0.63518559
76MET0.63355887
77FER0.62381625
78NTRK10.59428287
79PRKAA10.59015551
80MUSK0.58482027
81MKNK10.57391507
82MELK0.57053330
83INSR0.55826605
84PRKCI0.53954815
85STK380.53330057
86ROCK10.52204073
87PAK30.51790908
88FGFR20.50466482
89MAPK150.50398792
90TNIK0.50199721
91ERBB20.50167645
92BMPR1B0.49492651
93CAMK2A0.48849549
94MAPKAPK50.48760543
95PRKCH0.48179915
96MAPK70.47670342
97MAPK120.46821502
98ERBB40.46435215
99PLK20.45495388
100BCKDK0.45172281
101DYRK20.44790949
102GRK70.43974097
103TXK0.43803678
104IRAK10.42898748
105PKN10.42349569
106GRK50.42031954
107CASK0.41788150
108CSNK1G20.40716523
109ABL10.40612185
110CSNK1A1L0.40212658
111EIF2AK30.40035544
112BCR0.39845924
113PBK0.39828953
114PAK20.39639459
115PRKCQ0.39623567
116PRKACA0.39348122
117MARK10.39234377
118PDGFRA0.38294195
119YES10.37354263
120PRKCA0.37251609
121NTRK20.36905399
122TEC0.36758245
123ABL20.36664599
124LRRK20.36015797
125TRPM70.35936501
126FGR0.35754519
127CDK60.35643930
128PRKG10.33089324
129LATS10.32515840
130CSNK1G10.32405345
131SIK10.31055987
132AKT20.30060789
133MAP2K20.28561751
134PRKD10.27284414
135SRC0.26923414
136ITK0.26732943
137DYRK1B0.26419638
138CSK0.26307370
139MAP3K60.24851758
140PRKCE0.23909511
141IRAK20.22783729
142MAP2K10.21745849
143EIF2AK20.21609978
144MARK20.20973039
145MAP3K70.20177989
146STK30.19602238
147EPHA40.19042471
148BMX0.18920915
149PDGFRB0.18885595

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.49424873
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.45579001
3Caffeine metabolism_Homo sapiens_hsa002323.38300892
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.30049327
5Butanoate metabolism_Homo sapiens_hsa006503.20346189
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88510740
7Vitamin digestion and absorption_Homo sapiens_hsa049772.87939749
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.77366096
9Propanoate metabolism_Homo sapiens_hsa006402.75195136
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.69475922
11Linoleic acid metabolism_Homo sapiens_hsa005912.68912315
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.57780953
13Protein digestion and absorption_Homo sapiens_hsa049742.52717166
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.47955038
15Bile secretion_Homo sapiens_hsa049762.46192727
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.42489279
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.34356115
18Peroxisome_Homo sapiens_hsa041462.30732137
19Tryptophan metabolism_Homo sapiens_hsa003802.13269683
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05945941
21Lysine degradation_Homo sapiens_hsa003102.00204976
22Fatty acid degradation_Homo sapiens_hsa000711.93927390
23Phototransduction_Homo sapiens_hsa047441.87209003
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86364001
25beta-Alanine metabolism_Homo sapiens_hsa004101.79174297
26Sulfur metabolism_Homo sapiens_hsa009201.75403760
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.69364383
28Arginine biosynthesis_Homo sapiens_hsa002201.65184981
29Ether lipid metabolism_Homo sapiens_hsa005651.63343888
30Mineral absorption_Homo sapiens_hsa049781.62804059
31Glutathione metabolism_Homo sapiens_hsa004801.60632718
32Fat digestion and absorption_Homo sapiens_hsa049751.54181344
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53492075
34Arginine and proline metabolism_Homo sapiens_hsa003301.53261372
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.50304166
36Pyruvate metabolism_Homo sapiens_hsa006201.49387275
37Fatty acid metabolism_Homo sapiens_hsa012121.47612624
38ECM-receptor interaction_Homo sapiens_hsa045121.46370192
39Adherens junction_Homo sapiens_hsa045201.41541804
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40809642
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.40588096
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38698668
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37774043
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37183136
45Nitrogen metabolism_Homo sapiens_hsa009101.32718857
46PPAR signaling pathway_Homo sapiens_hsa033201.28295359
47Protein export_Homo sapiens_hsa030601.22044011
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.15677177
49Focal adhesion_Homo sapiens_hsa045101.11630974
50Collecting duct acid secretion_Homo sapiens_hsa049661.10927714
51Basal transcription factors_Homo sapiens_hsa030221.00743024
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00247425
53Nicotine addiction_Homo sapiens_hsa050330.99276999
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99126304
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98569128
56Starch and sucrose metabolism_Homo sapiens_hsa005000.98081808
57One carbon pool by folate_Homo sapiens_hsa006700.96115963
58Fanconi anemia pathway_Homo sapiens_hsa034600.95242403
59Thyroid hormone synthesis_Homo sapiens_hsa049180.94124366
60Complement and coagulation cascades_Homo sapiens_hsa046100.93259973
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.91738852
62Circadian rhythm_Homo sapiens_hsa047100.88504940
63Selenocompound metabolism_Homo sapiens_hsa004500.81419762
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81200799
65Other glycan degradation_Homo sapiens_hsa005110.79959433
66Taste transduction_Homo sapiens_hsa047420.79278140
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.75766278
68Sphingolipid metabolism_Homo sapiens_hsa006000.75756921
69Oxidative phosphorylation_Homo sapiens_hsa001900.75350730
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74520550
71Renin-angiotensin system_Homo sapiens_hsa046140.73402669
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72731952
73Carbon metabolism_Homo sapiens_hsa012000.72193034
74Dorso-ventral axis formation_Homo sapiens_hsa043200.71940404
75Homologous recombination_Homo sapiens_hsa034400.69543653
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64914088
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64247264
78Regulation of autophagy_Homo sapiens_hsa041400.63791257
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63776060
80Prostate cancer_Homo sapiens_hsa052150.63758582
81Histidine metabolism_Homo sapiens_hsa003400.63705352
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62355470
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61810728
84Steroid biosynthesis_Homo sapiens_hsa001000.61437095
85Gastric acid secretion_Homo sapiens_hsa049710.60526088
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60445576
87Choline metabolism in cancer_Homo sapiens_hsa052310.57562391
88Tight junction_Homo sapiens_hsa045300.56882684
89Serotonergic synapse_Homo sapiens_hsa047260.56743669
90Morphine addiction_Homo sapiens_hsa050320.56588960
91Rap1 signaling pathway_Homo sapiens_hsa040150.54653192
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.52595306
93RNA polymerase_Homo sapiens_hsa030200.52395498
94TGF-beta signaling pathway_Homo sapiens_hsa043500.49777017
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.48165645
96Glycerolipid metabolism_Homo sapiens_hsa005610.47322788
97Phenylalanine metabolism_Homo sapiens_hsa003600.47241656
98Olfactory transduction_Homo sapiens_hsa047400.45948439
99Hedgehog signaling pathway_Homo sapiens_hsa043400.45895319
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44714100
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44500305
102Arachidonic acid metabolism_Homo sapiens_hsa005900.43506006
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.42376380
104Biosynthesis of amino acids_Homo sapiens_hsa012300.41864607
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41366675
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41137465
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40244185
108Hippo signaling pathway_Homo sapiens_hsa043900.40242985
109Basal cell carcinoma_Homo sapiens_hsa052170.40134317
110Vitamin B6 metabolism_Homo sapiens_hsa007500.39551779
111Insulin secretion_Homo sapiens_hsa049110.38656112
112Sulfur relay system_Homo sapiens_hsa041220.38410154
113FoxO signaling pathway_Homo sapiens_hsa040680.38034450
114Axon guidance_Homo sapiens_hsa043600.37878851
115Chemical carcinogenesis_Homo sapiens_hsa052040.37761483
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36207580
117Salivary secretion_Homo sapiens_hsa049700.36148144
118N-Glycan biosynthesis_Homo sapiens_hsa005100.35965089
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35485021
120Parkinsons disease_Homo sapiens_hsa050120.35031140
121Cardiac muscle contraction_Homo sapiens_hsa042600.34923046
122Small cell lung cancer_Homo sapiens_hsa052220.34445767
123Proteoglycans in cancer_Homo sapiens_hsa052050.34161235
124ABC transporters_Homo sapiens_hsa020100.31724794
125GABAergic synapse_Homo sapiens_hsa047270.31300022
126Melanoma_Homo sapiens_hsa052180.31066490
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31037363
128Insulin resistance_Homo sapiens_hsa049310.30209239
129Ovarian steroidogenesis_Homo sapiens_hsa049130.29958634
130HIF-1 signaling pathway_Homo sapiens_hsa040660.29198105
131Fatty acid elongation_Homo sapiens_hsa000620.28198925
132Retinol metabolism_Homo sapiens_hsa008300.27340464
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26236125
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24607266
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24484698
136Ras signaling pathway_Homo sapiens_hsa040140.22620477
137Metabolic pathways_Homo sapiens_hsa011000.21728690
138Folate biosynthesis_Homo sapiens_hsa007900.21727996
139Renin secretion_Homo sapiens_hsa049240.21057397
140MicroRNAs in cancer_Homo sapiens_hsa052060.20632082
141Tyrosine metabolism_Homo sapiens_hsa003500.20384839
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18521595
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17850763
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16127175
145Pathways in cancer_Homo sapiens_hsa052000.15264923

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