SLC16A11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.63186500
2cilium or flagellum-dependent cell motility (GO:0001539)8.00433029
3motile cilium assembly (GO:0044458)6.16282389
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.92174830
5L-phenylalanine catabolic process (GO:0006559)5.92174830
6L-phenylalanine metabolic process (GO:0006558)5.75508749
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.75508749
8cilium movement (GO:0003341)5.49516390
9GDP-mannose metabolic process (GO:0019673)5.11693917
10thyroid hormone generation (GO:0006590)4.97730564
11aromatic amino acid family catabolic process (GO:0009074)4.95595747
12ethanol oxidation (GO:0006069)4.78188324
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.63545396
14glyoxylate metabolic process (GO:0046487)4.48856913
15sulfur amino acid catabolic process (GO:0000098)4.47040129
16drug catabolic process (GO:0042737)4.38797234
17high-density lipoprotein particle remodeling (GO:0034375)4.37238051
18primary alcohol catabolic process (GO:0034310)4.37209248
19bile acid biosynthetic process (GO:0006699)4.35479974
20cysteine metabolic process (GO:0006534)4.32242648
21tryptophan metabolic process (GO:0006568)4.31904041
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.29168244
23epithelial cilium movement (GO:0003351)4.26874674
24alpha-linolenic acid metabolic process (GO:0036109)4.26750515
25thyroid hormone metabolic process (GO:0042403)4.21578785
26indolalkylamine catabolic process (GO:0046218)4.20916895
27tryptophan catabolic process (GO:0006569)4.20916895
28indole-containing compound catabolic process (GO:0042436)4.20916895
29kynurenine metabolic process (GO:0070189)4.18466603
30negative regulation of fibrinolysis (GO:0051918)4.07435511
31cellular glucuronidation (GO:0052695)4.05603688
32axoneme assembly (GO:0035082)4.05395724
33exogenous drug catabolic process (GO:0042738)3.99219675
34lung epithelium development (GO:0060428)3.97525131
35negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.94444465
36glutamate metabolic process (GO:0006536)3.88892879
37urea metabolic process (GO:0019627)3.88240843
38urea cycle (GO:0000050)3.88240843
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.87769903
40negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.86426744
41uronic acid metabolic process (GO:0006063)3.85541783
42glucuronate metabolic process (GO:0019585)3.85541783
43tyrosine metabolic process (GO:0006570)3.84899841
44amino-acid betaine metabolic process (GO:0006577)3.83959982
45aromatic amino acid family metabolic process (GO:0009072)3.81262532
46left/right pattern formation (GO:0060972)3.77787350
47regulation of humoral immune response (GO:0002920)3.74843853
48lysine metabolic process (GO:0006553)3.74691849
49lysine catabolic process (GO:0006554)3.74691849
50bile acid metabolic process (GO:0008206)3.73900953
51serine family amino acid catabolic process (GO:0009071)3.70377815
52regulation of fibrinolysis (GO:0051917)3.68299356
53regulation of cholesterol esterification (GO:0010872)3.67313937
54vitamin transmembrane transport (GO:0035461)3.66357537
55reverse cholesterol transport (GO:0043691)3.65673588
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.64552471
57nitrogen cycle metabolic process (GO:0071941)3.64438020
58response to nitrosative stress (GO:0051409)3.60831257
59flavonoid metabolic process (GO:0009812)3.60594129
60protein carboxylation (GO:0018214)3.60111832
61peptidyl-glutamic acid carboxylation (GO:0017187)3.60111832
62tolerance induction (GO:0002507)3.58334811
63negative regulation of lipase activity (GO:0060192)3.57142413
64cellular ketone body metabolic process (GO:0046950)3.54369198
65benzene-containing compound metabolic process (GO:0042537)3.51377910
66sensory perception of smell (GO:0007608)3.50677968
67regulation of apoptotic cell clearance (GO:2000425)3.50469624
68alpha-amino acid catabolic process (GO:1901606)3.50420503
69protein-lipid complex remodeling (GO:0034368)3.50053363
70macromolecular complex remodeling (GO:0034367)3.50053363
71plasma lipoprotein particle remodeling (GO:0034369)3.50053363
72short-chain fatty acid metabolic process (GO:0046459)3.49713588
73regulation of protein activation cascade (GO:2000257)3.46703591
74dicarboxylic acid biosynthetic process (GO:0043650)3.46208295
75xenobiotic catabolic process (GO:0042178)3.45984367
76antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.45579869
77mannose metabolic process (GO:0006013)3.40088212
78positive regulation of lipoprotein lipase activity (GO:0051006)3.38777239
79positive regulation of triglyceride lipase activity (GO:0061365)3.38777239
80negative regulation of sterol transport (GO:0032372)3.37765638
81negative regulation of cholesterol transport (GO:0032375)3.37765638
82ethanol metabolic process (GO:0006067)3.37733790
83drug transmembrane transport (GO:0006855)3.34905456
84indolalkylamine metabolic process (GO:0006586)3.34884605
85cellular amino acid catabolic process (GO:0009063)3.34455202
86phospholipid efflux (GO:0033700)3.30273426
87cellular modified amino acid catabolic process (GO:0042219)3.29834699
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28857351
89triglyceride homeostasis (GO:0070328)3.28368228
90acylglycerol homeostasis (GO:0055090)3.28368228
91positive regulation of tolerance induction (GO:0002645)3.26843827
92renal absorption (GO:0070293)3.23977313
93regulation of triglyceride catabolic process (GO:0010896)3.22074885
94negative regulation of stress fiber assembly (GO:0051497)3.22000316
95aldehyde catabolic process (GO:0046185)3.21367189
96regulation of complement activation (GO:0030449)3.21354092
97positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.20254652
98complement activation, alternative pathway (GO:0006957)3.18583081
99antigen processing and presentation of endogenous antigen (GO:0019883)3.17817647
100imidazole-containing compound metabolic process (GO:0052803)3.17143875
101coenzyme catabolic process (GO:0009109)3.16661622
102regulation of cholesterol homeostasis (GO:2000188)3.16660426
103regulation of bile acid biosynthetic process (GO:0070857)3.16012919
104cholesterol efflux (GO:0033344)3.15930137
105regulation of cholesterol biosynthetic process (GO:0045540)3.15405507
106negative regulation of B cell mediated immunity (GO:0002713)3.12045740
107negative regulation of immunoglobulin mediated immune response (GO:0002890)3.12045740
108drug metabolic process (GO:0017144)3.11140757
109negative regulation of humoral immune response (GO:0002921)3.07299758
110regulation of cholesterol metabolic process (GO:0090181)3.04477410
111L-ascorbic acid metabolic process (GO:0019852)3.03317826
112ketone body metabolic process (GO:1902224)3.03169752
113response to pheromone (GO:0019236)3.00030822
114bile acid and bile salt transport (GO:0015721)2.99686012
115carnitine metabolic process (GO:0009437)2.99602678
116carboxylic acid catabolic process (GO:0046395)2.97782398
117organic acid catabolic process (GO:0016054)2.97782398
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.95112092
119negative regulation of protein activation cascade (GO:2000258)2.94813183
120homocysteine metabolic process (GO:0050667)2.92330865
121gamma-aminobutyric acid transport (GO:0015812)2.91413133
122positive regulation of fatty acid biosynthetic process (GO:0045723)2.90613400
123arginine metabolic process (GO:0006525)2.89503872
124monocarboxylic acid catabolic process (GO:0072329)2.89339692
125drug transport (GO:0015893)2.87613139
126regulation of tolerance induction (GO:0002643)2.86925573
127fatty acid oxidation (GO:0019395)2.86816843
128plasma lipoprotein particle clearance (GO:0034381)2.85405252
129positive regulation of extracellular matrix organization (GO:1903055)2.85045156
130pyrimidine nucleoside catabolic process (GO:0046135)2.83122592
131cellular biogenic amine catabolic process (GO:0042402)2.83089177
132amine catabolic process (GO:0009310)2.83089177
133aspartate family amino acid catabolic process (GO:0009068)2.82984114
134positive regulation of protein kinase C signaling (GO:0090037)2.82724725
135low-density lipoprotein particle remodeling (GO:0034374)2.81811677
136lipid oxidation (GO:0034440)2.81678065
137CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.80454034
138regulation of interleukin-13 production (GO:0032656)2.78879268
139positive thymic T cell selection (GO:0045059)2.78719810
140regulation of plasminogen activation (GO:0010755)2.77028847
141negative regulation of toll-like receptor signaling pathway (GO:0034122)2.74941897
142phenylpropanoid metabolic process (GO:0009698)2.74274202
143phosphate ion transmembrane transport (GO:0035435)2.72615541
144peptidyl-glutamic acid modification (GO:0018200)2.68836808
145fibrinolysis (GO:0042730)2.66994624
146proline metabolic process (GO:0006560)2.66924814
147phosphatidylcholine biosynthetic process (GO:0006656)2.66577302
148negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66027113
149negative regulation of cell killing (GO:0031342)2.66027113
150regulation of cytokine production involved in inflammatory response (GO:1900015)2.65346165
151negative regulation of actin filament bundle assembly (GO:0032232)2.64785000
152negative regulation of fatty acid biosynthetic process (GO:0045717)2.63160439
153regulation of gamma-delta T cell differentiation (GO:0045586)2.63103791
154phosphatidylethanolamine biosynthetic process (GO:0006646)2.61222656
155detection of bacterium (GO:0016045)2.58574373
156hydrogen peroxide biosynthetic process (GO:0050665)2.57352590
157thymic T cell selection (GO:0045061)2.57214562
158adenosine receptor signaling pathway (GO:0001973)2.56731949
159negative regulation of erythrocyte differentiation (GO:0045647)2.56084950
160response to phenylpropanoid (GO:0080184)2.54475061
161muscle organ morphogenesis (GO:0048644)2.53011044
162protein activation cascade (GO:0072376)2.51983141
163positive regulation of steroid metabolic process (GO:0045940)2.51255954
164primary alcohol metabolic process (GO:0034308)2.48921841
165glutathione biosynthetic process (GO:0006750)2.46897707
166regulation of skeletal muscle contraction (GO:0014819)2.46494422
167multicellular organismal water homeostasis (GO:0050891)2.44547721
168plasma lipoprotein particle assembly (GO:0034377)2.44462661
169regulation of fatty acid biosynthetic process (GO:0042304)2.43697851
170cellular response to ATP (GO:0071318)2.42526459
171sperm capacitation (GO:0048240)2.42453263
172regulation of gamma-delta T cell activation (GO:0046643)2.41185004
173progesterone metabolic process (GO:0042448)2.39944759
174acute-phase response (GO:0006953)2.39431340
175regulation of interleukin-5 production (GO:0032674)2.38657461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.87594433
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.24772057
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.32220680
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.05726859
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.30072942
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.22817566
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.19565964
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.15325213
9VDR_21846776_ChIP-Seq_THP-1_Human3.13345793
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.82709824
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.78365966
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.74177326
13EZH2_22144423_ChIP-Seq_EOC_Human2.59812178
14P68_20966046_ChIP-Seq_HELA_Human2.41638929
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.41303779
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19593003
17MAF_26560356_Chip-Seq_TH1_Human2.14202807
18DROSHA_22980978_ChIP-Seq_HELA_Human2.03969666
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.03787319
20MAF_26560356_Chip-Seq_TH2_Human2.02209981
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.00921642
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.99762978
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98487312
24MYC_22102868_ChIP-Seq_BL_Human1.93075877
25SA1_27219007_Chip-Seq_ERYTHROID_Human1.92165601
26BCL6_27268052_Chip-Seq_Bcells_Human1.84077953
27ELF1_20517297_ChIP-Seq_JURKAT_Human1.83955176
28* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83753780
29BCOR_27268052_Chip-Seq_Bcells_Human1.82426924
30GATA1_22025678_ChIP-Seq_K562_Human1.81710898
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78408602
32TET1_21451524_ChIP-Seq_MESCs_Mouse1.76282745
33* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.76046782
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75466987
35UTX_26944678_Chip-Seq_JUKART_Human1.74286755
36VDR_24763502_ChIP-Seq_THP-1_Human1.72792210
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70733665
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70486271
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70486271
40KDM2B_26808549_Chip-Seq_DND41_Human1.69725293
41TCF7_22412390_ChIP-Seq_EML_Mouse1.69426965
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68831174
43E2F1_20622854_ChIP-Seq_HELA_Human1.67195299
44PHF8_20622854_ChIP-Seq_HELA_Human1.64113115
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56629956
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.56445841
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56118137
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52466724
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50233376
50* RARB_24833708_ChIP-Seq_LIVER_Mouse1.49050934
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.45586065
52* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44469428
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.43647053
54* CTCF_21964334_Chip-Seq_Bcells_Human1.43233831
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42307049
56* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42210323
57* EZH2_27294783_Chip-Seq_ESCs_Mouse1.40605808
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39914308
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.39841313
60TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.39548865
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38983127
62CTCF_20526341_ChIP-Seq_ESCs_Human1.38361458
63YY1_22570637_ChIP-Seq_MALME-3M_Human1.37388703
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34948437
65* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34285067
66LXR_22292898_ChIP-Seq_THP-1_Human1.32893105
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29356141
68REST_21632747_ChIP-Seq_MESCs_Mouse1.29143239
69* SA1_27219007_Chip-Seq_Bcells_Human1.29051405
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28941316
71CTCF_21964334_ChIP-Seq_BJAB-B_Human1.28789407
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27318641
73RARA_24833708_ChIP-Seq_LIVER_Mouse1.26917974
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26087081
75TP53_22127205_ChIP-Seq_IMR90_Human1.26004241
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25938656
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.25866570
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24619280
79TP63_22573176_ChIP-Seq_HFKS_Human1.24061283
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23989159
81* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23280405
82* KDM2B_26808549_Chip-Seq_JURKAT_Human1.22849981
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.20715112
84RUNX1_27514584_Chip-Seq_MCF-7_Human1.20022697
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18383988
86RARB_27405468_Chip-Seq_BRAIN_Mouse1.18166844
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15733837
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.14858134
89* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14838007
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14415974
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14044303
92SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12880164
93P300_27268052_Chip-Seq_Bcells_Human1.12431913
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12167320
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11841611
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11763439
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10782641
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09519570
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09001224
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08845054
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08399977
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07801187
103GATA1_19941827_ChIP-Seq_MEL_Mouse1.07443565
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07269727
105ETS1_21867929_ChIP-Seq_TH2_Mouse1.07181718
106* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06430779
107* CTCF_26484167_Chip-Seq_Bcells_Mouse1.05145535
108KDM2B_26808549_Chip-Seq_K562_Human1.04466269
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04015475
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03904204
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03104278
112RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02840433
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02208232
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01819081
115STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01570215
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01189358
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00281537
118* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00040178
119GBX2_23144817_ChIP-Seq_PC3_Human0.99784580
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96715672
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95780845
122CLOCK_20551151_ChIP-Seq_293T_Human0.94652559
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93720784
124SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93409612
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.92299024
126ZNF263_19887448_ChIP-Seq_K562_Human0.91426770
127EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87817809
128* CTCF_27219007_Chip-Seq_Bcells_Human0.87214229
129RNF2_27304074_Chip-Seq_ESCs_Mouse0.86783308
130* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85324210
131HNF4A_19822575_ChIP-Seq_HepG2_Human0.83513160
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.83512572
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82625854
134RING1B_27294783_Chip-Seq_ESCs_Mouse0.82235871
135HTT_18923047_ChIP-ChIP_STHdh_Human0.81610166
136GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81395106
137GATA1_19941826_ChIP-Seq_K562_Human0.79041091
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79029831
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.78010761
140* RACK7_27058665_Chip-Seq_MCF-7_Human0.77959152
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76742099
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.76433294
143EZH2_27304074_Chip-Seq_ESCs_Mouse0.75432847
144* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75133449
145SMC4_20622854_ChIP-Seq_HELA_Human0.74956099
146PIAS1_25552417_ChIP-Seq_VCAP_Human0.73975462
147RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.72953243
148AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72789494
149HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72372737
150GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71509537
151AHR_22903824_ChIP-Seq_MCF-7_Human0.70110462
152MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.70083906
153* CREB1_26743006_Chip-Seq_LNCaP_Human0.66821152
154PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.66331925
155SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.66066218
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.65588925
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.65009934
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64963055
159KDM2B_26808549_Chip-Seq_SUP-B15_Human0.64519292
160CDX2_20551321_ChIP-Seq_CACO-2_Human0.64322868
161CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.63582760
162BCAT_22108803_ChIP-Seq_LS180_Human0.63440956
163RXRA_24833708_ChIP-Seq_LIVER_Mouse0.63389442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.67558370
2MP0008875_abnormal_xenobiotic_pharmacok5.75845074
3MP0005360_urolithiasis5.71536183
4MP0005365_abnormal_bile_salt4.93895742
5MP0005085_abnormal_gallbladder_physiolo4.40798523
6MP0001984_abnormal_olfaction3.74124898
7MP0002132_abnormal_respiratory_system3.57396976
8MP0005377_hearing/vestibular/ear_phenot3.17080679
9MP0003878_abnormal_ear_physiology3.17080679
10MP0009840_abnormal_foam_cell3.14958592
11MP0010329_abnormal_lipoprotein_level2.96985254
12MP0003806_abnormal_nucleotide_metabolis2.93421811
13MP0003252_abnormal_bile_duct2.91483315
14MP0001986_abnormal_taste_sensitivity2.86126931
15MP0003195_calcinosis2.65063846
16MP0005083_abnormal_biliary_tract2.52881184
17MP0003136_yellow_coat_color2.47860391
18MP0005332_abnormal_amino_acid2.41589851
19MP0002277_abnormal_respiratory_mucosa2.31424572
20MP0004381_abnormal_hair_follicle2.20794479
21MP0005409_darkened_coat_color2.19375680
22MP0001661_extended_life_span2.03174641
23MP0004043_abnormal_pH_regulation1.99516520
24MP0003763_abnormal_thymus_physiology1.96577322
25MP0004859_abnormal_synaptic_plasticity1.95310822
26MP0003436_decreased_susceptibility_to1.85710803
27MP0009333_abnormal_splenocyte_physiolog1.85334654
28MP0004019_abnormal_vitamin_homeostasis1.84786685
29MP0001666_abnormal_nutrient_absorption1.82679135
30MP0003172_abnormal_lysosome_physiology1.78503266
31MP0003303_peritoneal_inflammation1.74913191
32MP0002118_abnormal_lipid_homeostasis1.73287213
33MP0003011_delayed_dark_adaptation1.72528611
34MP0005584_abnormal_enzyme/coenzyme_acti1.72359195
35MP0005387_immune_system_phenotype1.65140243
36MP0001790_abnormal_immune_system1.65140243
37MP0003191_abnormal_cellular_cholesterol1.65073637
38MP0003329_amyloid_beta_deposits1.62972258
39MP0002138_abnormal_hepatobiliary_system1.56086476
40MP0000003_abnormal_adipose_tissue1.55287752
41MP0000685_abnormal_immune_system1.53485418
42MP0000013_abnormal_adipose_tissue1.53230806
43MP0003868_abnormal_feces_composition1.47333300
44MP0010155_abnormal_intestine_physiology1.47106867
45MP0003453_abnormal_keratinocyte_physiol1.46287469
46MP0003635_abnormal_synaptic_transmissio1.44530535
47MP0000609_abnormal_liver_physiology1.42495771
48MP0002653_abnormal_ependyma_morphology1.41094960
49MP0009745_abnormal_behavioral_response1.41060659
50MP0005394_taste/olfaction_phenotype1.40357290
51MP0005499_abnormal_olfactory_system1.40357290
52MP0005319_abnormal_enzyme/_coenzyme1.38867650
53MP0000681_abnormal_thyroid_gland1.37633026
54MP0002933_joint_inflammation1.36822143
55MP0005666_abnormal_adipose_tissue1.36466349
56MP0009643_abnormal_urine_homeostasis1.35045446
57MP0005375_adipose_tissue_phenotype1.35043781
58MP0001800_abnormal_humoral_immune1.29973175
59MP0003879_abnormal_hair_cell1.27552761
60MP0005025_abnormal_response_to1.26015515
61MP0009046_muscle_twitch1.24219205
62MP0001501_abnormal_sleep_pattern1.22622439
63MP0002909_abnormal_adrenal_gland1.20255753
64MP0005671_abnormal_response_to1.20095769
65MP0005058_abnormal_lysosome_morphology1.19720356
66MP0004130_abnormal_muscle_cell1.19276790
67MP0002272_abnormal_nervous_system1.17372449
68MP0003690_abnormal_glial_cell1.14438280
69MP0002876_abnormal_thyroid_physiology1.14410368
70MP0010234_abnormal_vibrissa_follicle1.13824148
71MP0005076_abnormal_cell_differentiation1.13302301
72MP0000566_synostosis1.12881584
73MP0005623_abnormal_meninges_morphology1.11852923
74MP0005464_abnormal_platelet_physiology1.11724636
75MP0000604_amyloidosis1.11670651
76MP0002063_abnormal_learning/memory/cond1.11627326
77MP0010368_abnormal_lymphatic_system1.11359630
78MP0002064_seizures1.11074689
79MP0005000_abnormal_immune_tolerance1.11066964
80MP0000678_abnormal_parathyroid_gland1.10505654
81MP0005636_abnormal_mineral_homeostasis1.09698689
82MP0002136_abnormal_kidney_physiology1.06759031
83MP0004947_skin_inflammation1.06490923
84MP0002723_abnormal_immune_serum1.05999403
85MP0002822_catalepsy1.05608493
86MP0005423_abnormal_somatic_nervous1.02218670
87MP0001756_abnormal_urination1.02103182
88MP0003091_abnormal_cell_migration1.01520324
89MP0002249_abnormal_larynx_morphology1.01277764
90MP0008872_abnormal_physiological_respon1.01046965
91MP0002405_respiratory_system_inflammati1.00992879
92MP0008469_abnormal_protein_level0.98324296
93MP0008874_decreased_physiological_sensi0.98205374
94MP0008789_abnormal_olfactory_epithelium0.98158479
95MP0001879_abnormal_lymphatic_vessel0.96923780
96MP0003075_altered_response_to0.96508116
97MP0002452_abnormal_antigen_presenting0.95947535
98MP0000751_myopathy0.94476198
99MP0002572_abnormal_emotion/affect_behav0.94147097
100MP0005670_abnormal_white_adipose0.93466922
101MP0005535_abnormal_body_temperature0.92899391
102MP0003186_abnormal_redox_activity0.92831974
103MP0009764_decreased_sensitivity_to0.91667899
104MP0002420_abnormal_adaptive_immunity0.91367566
105MP0009785_altered_susceptibility_to0.90726881
106MP0008569_lethality_at_weaning0.90601607
107MP0001819_abnormal_immune_cell0.90551821
108MP0005330_cardiomyopathy0.90217698
109MP0001765_abnormal_ion_homeostasis0.90209998
110MP0005084_abnormal_gallbladder_morpholo0.89111511
111MP0004185_abnormal_adipocyte_glucose0.88823812
112MP0004885_abnormal_endolymph0.86941020
113MP0005174_abnormal_tail_pigmentation0.85783424
114MP0005645_abnormal_hypothalamus_physiol0.84229903
115MP0009765_abnormal_xenobiotic_induced0.84020703
116MP0003866_abnormal_defecation0.82231759
117MP0003638_abnormal_response/metabolism_0.82203931
118MP0002398_abnormal_bone_marrow0.81426217
119MP0001764_abnormal_homeostasis0.81134709
120MP0000249_abnormal_blood_vessel0.80991739
121MP0000858_altered_metastatic_potential0.80835109
122MP0002419_abnormal_innate_immunity0.79132548
123MP0002557_abnormal_social/conspecific_i0.78977793
124MP0002078_abnormal_glucose_homeostasis0.78963621
125MP0001958_emphysema0.78199625
126MP0001845_abnormal_inflammatory_respons0.77511094
127MP0009697_abnormal_copulation0.77208646
128MP0001849_ear_inflammation0.76894505
129MP0000716_abnormal_immune_system0.76827501
130MP0001873_stomach_inflammation0.76538028
131MP0002102_abnormal_ear_morphology0.76411825
132MP0005220_abnormal_exocrine_pancreas0.76222564
133MP0001968_abnormal_touch/_nociception0.74834616
134MP0005171_absent_coat_pigmentation0.73926069
135MP0001835_abnormal_antigen_presentation0.73905695
136MP0002734_abnormal_mechanical_nocicepti0.73535212
137MP0006036_abnormal_mitochondrial_physio0.72881840
138MP0001440_abnormal_grooming_behavior0.72016070
139MP0002067_abnormal_sensory_capabilities0.71893801
140MP0004270_analgesia0.70829601
141MP0009642_abnormal_blood_homeostasis0.70620527
142MP0003633_abnormal_nervous_system0.70234376
143MP0003953_abnormal_hormone_level0.70017930
144MP0005647_abnormal_sex_gland0.68585564
145MP0003705_abnormal_hypodermis_morpholog0.66864089
146MP0005167_abnormal_blood-brain_barrier0.65882343
147MP0002184_abnormal_innervation0.65651242
148MP0002736_abnormal_nociception_after0.64325170
149MP0004782_abnormal_surfactant_physiolog0.63958903
150MP0002168_other_aberrant_phenotype0.63257468
151MP0001177_atelectasis0.62921943
152MP0002971_abnormal_brown_adipose0.62840287
153MP0003656_abnormal_erythrocyte_physiolo0.62440577
154MP0002928_abnormal_bile_duct0.62392307
155MP0001502_abnormal_circadian_rhythm0.60617715
156MP0005187_abnormal_penis_morphology0.59586587
157MP0000598_abnormal_liver_morphology0.59214341
158MP0002069_abnormal_eating/drinking_beha0.59051473
159MP0001486_abnormal_startle_reflex0.58128591
160MP0005451_abnormal_body_composition0.57731330
161MP0005448_abnormal_energy_balance0.57491179
162MP0000639_abnormal_adrenal_gland0.57209401
163MP0005376_homeostasis/metabolism_phenot0.56753700
164MP0005595_abnormal_vascular_smooth0.55527382
165MP0002254_reproductive_system_inflammat0.55037414
166MP0004142_abnormal_muscle_tone0.53701451
167MP0002735_abnormal_chemical_nociception0.53376533

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.44651552
2Abnormal respiratory epithelium morphology (HP:0012253)6.93637998
3Abnormal respiratory motile cilium morphology (HP:0005938)6.93637998
4Abnormal respiratory motile cilium physiology (HP:0012261)6.56174411
5Abnormal ciliary motility (HP:0012262)6.42235124
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.42078475
7Absent/shortened dynein arms (HP:0200106)6.42078475
8Abnormality of aromatic amino acid family metabolism (HP:0004338)6.16980660
9Rhinitis (HP:0012384)5.93395487
10Nasal polyposis (HP:0100582)5.72186570
11Deep venous thrombosis (HP:0002625)5.47487006
12Abnormality of monocarboxylic acid metabolism (HP:0010996)5.06515900
13Bronchiectasis (HP:0002110)5.04831532
14Abnormality of the nasal mucosa (HP:0000433)5.03056819
15Intrahepatic cholestasis (HP:0001406)4.61950210
16Hyperactive renin-angiotensin system (HP:0000841)4.54468221
17Hemorrhage of the eye (HP:0011885)4.48342250
18Xanthomatosis (HP:0000991)4.45223172
19Hyperlipoproteinemia (HP:0010980)4.38945309
20Hypobetalipoproteinemia (HP:0003563)4.35441788
21Prolonged partial thromboplastin time (HP:0003645)4.34296501
22Recurrent sinusitis (HP:0011108)4.19619267
23Delayed CNS myelination (HP:0002188)4.08095811
24Ketosis (HP:0001946)3.81490195
25Testicular atrophy (HP:0000029)3.70247485
26Conjugated hyperbilirubinemia (HP:0002908)3.65504119
27Hypokalemic alkalosis (HP:0001949)3.64065729
28Recurrent otitis media (HP:0000403)3.45459100
29Bronchitis (HP:0012387)3.44666395
30Chronic bronchitis (HP:0004469)3.44155612
31Gout (HP:0001997)3.43853938
32Ketoacidosis (HP:0001993)3.40900842
33Hyperammonemia (HP:0001987)3.37325594
34Hyperglycinuria (HP:0003108)3.37251794
35Goiter (HP:0000853)3.32123419
36Alkalosis (HP:0001948)3.31202630
37Chronic sinusitis (HP:0011109)3.24719961
38Hyperglycinemia (HP:0002154)3.21830466
39Hyperaldosteronism (HP:0000859)3.20133133
40Abnormality of glutamine family amino acid metabolism (HP:0010902)3.17674219
41Hypolipoproteinemia (HP:0010981)3.17364749
42Joint hemorrhage (HP:0005261)3.09363237
43Thin bony cortex (HP:0002753)3.08765168
44Male infertility (HP:0003251)3.01321277
45Abnormality of serine family amino acid metabolism (HP:0010894)2.99185655
46Abnormality of glycine metabolism (HP:0010895)2.99185655
47Complement deficiency (HP:0004431)2.97665354
48Atelectasis (HP:0100750)2.94430925
49Infertility (HP:0000789)2.90935386
50Metabolic acidosis (HP:0001942)2.90384292
51Abnormality of the common coagulation pathway (HP:0010990)2.90266898
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.85715180
53Hypoalphalipoproteinemia (HP:0003233)2.83319312
54Hypoglycemic coma (HP:0001325)2.82679979
55Renal salt wasting (HP:0000127)2.81507502
56Hyperbilirubinemia (HP:0002904)2.78945477
57Chronic otitis media (HP:0000389)2.77401280
58Annular pancreas (HP:0001734)2.73284560
59Epidermoid cyst (HP:0200040)2.73269853
60Decreased circulating renin level (HP:0003351)2.72213550
61Fat malabsorption (HP:0002630)2.69151279
62Recurrent bronchitis (HP:0002837)2.67840546
63Vascular calcification (HP:0004934)2.65825234
64Status epilepticus (HP:0002133)2.65192816
65Abnormality of the intrinsic pathway (HP:0010989)2.63038592
66Abnormality of sulfur amino acid metabolism (HP:0004339)2.61002546
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56198725
68Mesangial abnormality (HP:0001966)2.55455948
69Abnormality of purine metabolism (HP:0004352)2.54991863
70Abnormality of fatty-acid metabolism (HP:0004359)2.52526251
71Vaginal fistula (HP:0004320)2.51189166
72Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.50024160
73Glomerulonephritis (HP:0000099)2.48704004
74Aplasia of the musculature (HP:0100854)2.46358100
75Abnormality of chloride homeostasis (HP:0011422)2.43806791
76Hypercholesterolemia (HP:0003124)2.41012185
77Neonatal onset (HP:0003623)2.40559468
78Abnormality of nucleobase metabolism (HP:0010932)2.37984182
79Thyroid-stimulating hormone excess (HP:0002925)2.35210299
80Abnormality of renin-angiotensin system (HP:0000847)2.34742905
81Late onset (HP:0003584)2.34141272
82Cardiovascular calcification (HP:0011915)2.29581143
83Systemic lupus erythematosus (HP:0002725)2.28704647
84Obstructive sleep apnea (HP:0002870)2.28136311
85Visual hallucinations (HP:0002367)2.24918117
86Pili torti (HP:0003777)2.24770008
87Popliteal pterygium (HP:0009756)2.22923998
88Sensorimotor neuropathy (HP:0007141)2.19728597
89Hyperkalemia (HP:0002153)2.19643809
90Action tremor (HP:0002345)2.19567856
91Abnormality of methionine metabolism (HP:0010901)2.19341854
92Spontaneous abortion (HP:0005268)2.18704270
93Purpura (HP:0000979)2.18244759
94Irritability (HP:0000737)2.16321972
95Esophageal varix (HP:0002040)2.16072618
96Ulnar bowing (HP:0003031)2.15656827
97Confusion (HP:0001289)2.15000807
98Abnormality of the lower motor neuron (HP:0002366)2.14119484
99Gastrointestinal stroma tumor (HP:0100723)2.08724524
100Emphysema (HP:0002097)2.08702603
101Amyloidosis (HP:0011034)2.05043336
102Spastic diplegia (HP:0001264)2.05039945
103Hepatocellular carcinoma (HP:0001402)2.04902524
104Focal dystonia (HP:0004373)2.04053854
105Abnormality of pyrimidine metabolism (HP:0004353)2.03968820
106Nephritis (HP:0000123)2.03891061
107Occipital encephalocele (HP:0002085)2.02821544
108Abnormality of complement system (HP:0005339)2.01765033
109Craniofacial dystonia (HP:0012179)2.00928283
110Hypoglycemic seizures (HP:0002173)2.00156526
111Decreased central vision (HP:0007663)1.99510238
112Hypochromic microcytic anemia (HP:0004840)1.99150974
113Dyschromatopsia (HP:0007641)1.98705820
114Torticollis (HP:0000473)1.98047639
115Abnormality of sodium homeostasis (HP:0010931)1.97431282
116Atrioventricular block (HP:0001678)1.97096385
117Hyperuricemia (HP:0002149)1.97060000
118Increased purine levels (HP:0004368)1.97060000
119Focal motor seizures (HP:0011153)1.96874150
120Rib fusion (HP:0000902)1.96803082
121Myokymia (HP:0002411)1.96327295
122Lethargy (HP:0001254)1.94680059
123Poikilocytosis (HP:0004447)1.94399655
124Fetal akinesia sequence (HP:0001989)1.93406236
125Steatorrhea (HP:0002570)1.93218431
126Epistaxis (HP:0000421)1.92924078
127Intestinal fistula (HP:0100819)1.91817517
128Urinary glycosaminoglycan excretion (HP:0003541)1.90533171
129Mucopolysacchariduria (HP:0008155)1.90533171
130Abnormal hair laboratory examination (HP:0003328)1.89735417
131Cholelithiasis (HP:0001081)1.89715282
132Tetany (HP:0001281)1.89666329
133Abnormality of serum amino acid levels (HP:0003112)1.89657565
134Abnormal gallbladder morphology (HP:0012437)1.89384772
135Renal tubular acidosis (HP:0001947)1.88000729
136Menorrhagia (HP:0000132)1.87820391
137Turricephaly (HP:0000262)1.87496610
138Vomiting (HP:0002013)1.85674204
139Death in childhood (HP:0003819)1.85105824
140Joint stiffness (HP:0001387)1.84798897
141Recurrent gram-negative bacterial infections (HP:0005420)1.84120253
142Malnutrition (HP:0004395)1.84114996
143Nephrolithiasis (HP:0000787)1.84059469
144Tetraplegia (HP:0002445)1.84022314
145Polycythemia (HP:0001901)1.83721063
146Metabolic alkalosis (HP:0200114)1.83459124
147Abnormal gallbladder physiology (HP:0012438)1.82850135
148Cholecystitis (HP:0001082)1.82850135
149Rectal fistula (HP:0100590)1.82666326
150Rectovaginal fistula (HP:0000143)1.82666326
151Colitis (HP:0002583)1.82449520
152Hypertriglyceridemia (HP:0002155)1.80991286
153Hyponatremia (HP:0002902)1.80842185
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80274968
155Abnormality of polysaccharide metabolism (HP:0011012)1.80274968
156Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80274968
157Brushfield spots (HP:0001088)1.79637522
158Adrenal overactivity (HP:0002717)1.78323239
159Eczematoid dermatitis (HP:0000976)1.77929158
160Anteriorly placed anus (HP:0001545)1.72436930
161Stridor (HP:0010307)1.70327349
162Gastrointestinal infarctions (HP:0005244)1.69150540
163Increased serum ferritin (HP:0003281)1.67621680
164Hypophosphatemic rickets (HP:0004912)1.66497121
165Cervical subluxation (HP:0003308)1.66474584
166Poikiloderma (HP:0001029)1.62043824
167Attenuation of retinal blood vessels (HP:0007843)1.58119248
168Myopathic facies (HP:0002058)1.56707840
169Rickets (HP:0002748)1.56121657
170Increased IgE level (HP:0003212)1.55860177
171Increased muscle lipid content (HP:0009058)1.53116609
172Abnormality of the radial head (HP:0003995)1.52108170
173Polygenic inheritance (HP:0010982)1.51597972
174Dislocated radial head (HP:0003083)1.49448771
175Hyperinsulinemic hypoglycemia (HP:0000825)1.46820648
176Widely patent fontanelles and sutures (HP:0004492)1.44846007
177Abnormal albumin level (HP:0012116)1.44796948
178Hypoalbuminemia (HP:0003073)1.44796948
179Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.41842916
180Myositis (HP:0100614)1.41515188
181Meningitis (HP:0001287)1.41368262
182Gastrointestinal inflammation (HP:0004386)1.39903150

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.61160623
2BCKDK3.53862410
3DAPK23.06036329
4CAMKK22.96252395
5SMG12.78597371
6RIPK12.57330340
7MAP2K42.53013876
8MAP4K12.51243642
9RIPK42.47195508
10ERN12.36444387
11NTRK32.24801677
12SIK12.03846710
13CAMKK12.00508793
14TBK11.94817689
15LMTK21.78889972
16EPHA21.78357672
17GRK61.77896447
18PRPF4B1.76573244
19BLK1.73592998
20MAP3K41.73146402
21TAOK11.72767175
22ERBB31.70453393
23STK381.67128777
24PINK11.64360897
25FLT31.62962222
26NME11.59478209
27CSK1.58288436
28MAP3K91.56673975
29TNIK1.55439827
30TRIB31.55211254
31EPHA41.49191884
32MAP3K21.44105392
33TYK21.43865533
34MINK11.43481807
35ZAP701.40005014
36MAP2K71.38813988
37STK161.36833608
38MAP2K31.34276524
39DAPK11.31726355
40KDR1.30872257
41MAPKAPK31.27628528
42STK241.27526852
43INSRR1.27322001
44MAP3K131.26032237
45PIM21.25299111
46CAMK2G1.21972327
47MST41.20463517
48ICK1.19893307
49LRRK21.17755446
50PASK1.17726493
51MAP3K61.16190682
52FRK1.15505283
53PRKCG1.14584509
54CAMK2B1.14534599
55CAMK11.14353866
56CDK191.13942075
57TNK21.11957606
58PAK31.11396294
59BTK1.10935529
60MAP3K31.09856324
61FGFR41.09471069
62CAMK41.09405599
63FER1.08373830
64MAP3K101.07281566
65PTK21.05077344
66CAMK1G1.04623334
67CAMK1D1.03176060
68PRKD20.98869715
69CAMK2D0.98488477
70TLK10.97757797
71MAP3K70.96610984
72NTRK20.96174456
73MAP2K60.95949622
74TESK10.95018004
75PTK60.93518422
76PIK3CG0.92621280
77PRKG20.91251240
78KSR20.89319122
79PAK60.87722464
80CDK40.87658809
81TIE10.87238650
82IKBKE0.87090784
83OXSR10.86523126
84TXK0.86467494
85CDC42BPA0.85870374
86EEF2K0.84824512
87WNK40.82482089
88TAOK30.82260586
89PHKG10.79963860
90PHKG20.79963860
91SGK4940.79742001
92SGK2230.79742001
93DYRK1B0.79697044
94SGK30.78831993
95MAPK70.78748637
96TEC0.78028873
97MAP3K10.76624747
98RET0.73155038
99NTRK10.72239742
100MAP2K20.72045769
101PRKCQ0.72011632
102PDPK10.70975449
103HIPK20.70255754
104JAK10.68345521
105MAP3K140.67973319
106SYK0.66600736
107SIK20.64802045
108SGK20.64767223
109BMPR20.64535688
110IRAK40.63900148
111CAMK2A0.63787416
112HCK0.63622001
113PKN20.61580133
114PRKCZ0.61207028
115CDK50.61191620
116ARAF0.60814656
117JAK30.60484396
118FES0.60425981
119MST1R0.60264278
120IKBKB0.60261941
121MARK20.59791971
122RPS6KC10.59065585
123RPS6KL10.59065585
124UHMK10.59045341
125WNK30.58338399
126PRKD30.57992545
127MAP2K10.57219632
128LYN0.56371263
129ITK0.56314300
130PRKCH0.55118516
131CSNK1G20.52752521
132FGFR20.52519557
133TESK20.51768599
134RPS6KA20.51723383
135MAP3K110.51718851
136FGFR30.51140195
137MAPK110.50107741
138PRKAA20.49965712
139BMX0.49626607
140MUSK0.49223744
141DAPK30.48524092
142RPS6KA60.47683604
143TAOK20.46975893
144ILK0.46503106
145STK110.46460939
146WNK10.43701085
147PRKACG0.43104874
148MAPK120.42835329
149PRKAA10.42111280
150PDK10.41979833
151PTK2B0.41943590
152EPHB10.41268082
153ERBB20.41163055
154LCK0.40938656
155CHUK0.40170297
156CDK120.40108811
157SIK30.39714080
158PRKD10.38025328
159NLK0.37164666
160STK100.36005531
161TRPM70.35741266
162RPS6KA50.34756501

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.73859719
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.44073855
3Nitrogen metabolism_Homo sapiens_hsa009102.92808238
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.69394992
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61026933
6Arginine biosynthesis_Homo sapiens_hsa002202.59147262
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.41891021
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30160933
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.23855205
10Chemical carcinogenesis_Homo sapiens_hsa052042.18455739
11Fatty acid degradation_Homo sapiens_hsa000712.17444090
12Tryptophan metabolism_Homo sapiens_hsa003802.12679119
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.12441411
14Bile secretion_Homo sapiens_hsa049762.08607082
15Butanoate metabolism_Homo sapiens_hsa006502.08341693
16Primary immunodeficiency_Homo sapiens_hsa053401.98400113
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.94553988
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87561122
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85232269
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80655937
21beta-Alanine metabolism_Homo sapiens_hsa004101.76495135
22Olfactory transduction_Homo sapiens_hsa047401.74356737
23Peroxisome_Homo sapiens_hsa041461.73080229
24Complement and coagulation cascades_Homo sapiens_hsa046101.71781376
25Fructose and mannose metabolism_Homo sapiens_hsa000511.70153249
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.69972346
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69476556
28Histidine metabolism_Homo sapiens_hsa003401.65878759
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65062748
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.63166462
31Retinol metabolism_Homo sapiens_hsa008301.61736738
32Caffeine metabolism_Homo sapiens_hsa002321.58664442
33Sulfur metabolism_Homo sapiens_hsa009201.57504261
34Other glycan degradation_Homo sapiens_hsa005111.56772727
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48854614
36Propanoate metabolism_Homo sapiens_hsa006401.45392698
37Autoimmune thyroid disease_Homo sapiens_hsa053201.43739215
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42669044
39Tyrosine metabolism_Homo sapiens_hsa003501.40604019
40PPAR signaling pathway_Homo sapiens_hsa033201.38347963
41Allograft rejection_Homo sapiens_hsa053301.34072338
42Fatty acid metabolism_Homo sapiens_hsa012121.32481853
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.26488841
44Graft-versus-host disease_Homo sapiens_hsa053321.25829172
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24230560
46ABC transporters_Homo sapiens_hsa020101.23853643
47Pyruvate metabolism_Homo sapiens_hsa006201.20597526
48Phenylalanine metabolism_Homo sapiens_hsa003601.20306011
49Thyroid hormone synthesis_Homo sapiens_hsa049181.19530585
50Starch and sucrose metabolism_Homo sapiens_hsa005001.18477365
51Sulfur relay system_Homo sapiens_hsa041221.12407727
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09331777
53Nicotine addiction_Homo sapiens_hsa050331.04470533
54Sphingolipid metabolism_Homo sapiens_hsa006001.04149125
55Selenocompound metabolism_Homo sapiens_hsa004501.02003490
56Notch signaling pathway_Homo sapiens_hsa043301.01664209
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.01143530
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96836753
59B cell receptor signaling pathway_Homo sapiens_hsa046620.96404171
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.95854414
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95722173
62Taste transduction_Homo sapiens_hsa047420.92195041
63GABAergic synapse_Homo sapiens_hsa047270.91932079
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.91857270
65Type I diabetes mellitus_Homo sapiens_hsa049400.87848288
66Glutathione metabolism_Homo sapiens_hsa004800.84619847
67Synaptic vesicle cycle_Homo sapiens_hsa047210.83976049
68Hepatitis C_Homo sapiens_hsa051600.81132686
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78745484
70Hematopoietic cell lineage_Homo sapiens_hsa046400.78685307
71Systemic lupus erythematosus_Homo sapiens_hsa053220.78150489
72Arginine and proline metabolism_Homo sapiens_hsa003300.76646946
73Folate biosynthesis_Homo sapiens_hsa007900.76138144
74Circadian rhythm_Homo sapiens_hsa047100.75707573
75Gastric acid secretion_Homo sapiens_hsa049710.75576520
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74422636
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73964496
78Carbon metabolism_Homo sapiens_hsa012000.73354903
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73056871
80Biosynthesis of amino acids_Homo sapiens_hsa012300.72392066
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71414258
82Glycerolipid metabolism_Homo sapiens_hsa005610.70178730
83Circadian entrainment_Homo sapiens_hsa047130.69157347
84Glutamatergic synapse_Homo sapiens_hsa047240.67584791
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.65034960
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64561343
87Salivary secretion_Homo sapiens_hsa049700.64246972
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63483494
89Insulin secretion_Homo sapiens_hsa049110.63016371
90Acute myeloid leukemia_Homo sapiens_hsa052210.62552654
91Vitamin digestion and absorption_Homo sapiens_hsa049770.61688216
92Fatty acid elongation_Homo sapiens_hsa000620.61200013
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61089829
94Galactose metabolism_Homo sapiens_hsa000520.59754490
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55413412
96Staphylococcus aureus infection_Homo sapiens_hsa051500.55008487
97Fat digestion and absorption_Homo sapiens_hsa049750.54631124
98Morphine addiction_Homo sapiens_hsa050320.54506321
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53745287
100Amphetamine addiction_Homo sapiens_hsa050310.52118885
101Antigen processing and presentation_Homo sapiens_hsa046120.51243594
102T cell receptor signaling pathway_Homo sapiens_hsa046600.51057795
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49290154
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48940456
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47942592
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47669575
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.47585255
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46850796
109Long-term potentiation_Homo sapiens_hsa047200.46145168
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45095710
111Lysine degradation_Homo sapiens_hsa003100.44590533
112Leishmaniasis_Homo sapiens_hsa051400.43085776
113Fatty acid biosynthesis_Homo sapiens_hsa000610.42154922
114Linoleic acid metabolism_Homo sapiens_hsa005910.41396147
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41020859
116Pertussis_Homo sapiens_hsa051330.40922719
117Arachidonic acid metabolism_Homo sapiens_hsa005900.40667414
118Herpes simplex infection_Homo sapiens_hsa051680.40432942
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35693984
120Tuberculosis_Homo sapiens_hsa051520.35109435
121Mineral absorption_Homo sapiens_hsa049780.35014077
122VEGF signaling pathway_Homo sapiens_hsa043700.34904105
123Viral myocarditis_Homo sapiens_hsa054160.34123204
124Lysosome_Homo sapiens_hsa041420.33373394
125Dopaminergic synapse_Homo sapiens_hsa047280.33193002
126Endocytosis_Homo sapiens_hsa041440.32621630
127Insulin signaling pathway_Homo sapiens_hsa049100.31290644
128Asthma_Homo sapiens_hsa053100.30712743
129cAMP signaling pathway_Homo sapiens_hsa040240.30348687
130Influenza A_Homo sapiens_hsa051640.30315615
131Osteoclast differentiation_Homo sapiens_hsa043800.29663250
132Cocaine addiction_Homo sapiens_hsa050300.29271465
133Glucagon signaling pathway_Homo sapiens_hsa049220.29123617
134Collecting duct acid secretion_Homo sapiens_hsa049660.28978806
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.28920236
136Toxoplasmosis_Homo sapiens_hsa051450.28726528
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28075242
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.26903079
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25775086
140Metabolic pathways_Homo sapiens_hsa011000.25725226
141Type II diabetes mellitus_Homo sapiens_hsa049300.23997917
142Pentose phosphate pathway_Homo sapiens_hsa000300.23279363
143Ovarian steroidogenesis_Homo sapiens_hsa049130.21152279
144Prion diseases_Homo sapiens_hsa050200.19117932
145Long-term depression_Homo sapiens_hsa047300.17561273
146Insulin resistance_Homo sapiens_hsa049310.16485583
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.16350729
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.16287901
149Cholinergic synapse_Homo sapiens_hsa047250.15991304
150Vibrio cholerae infection_Homo sapiens_hsa051100.15356907

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »