SLC16A10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.09699459
2L-phenylalanine catabolic process (GO:0006559)6.09699459
3L-phenylalanine metabolic process (GO:0006558)5.72317843
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.72317843
5Golgi transport vesicle coating (GO:0048200)5.41075212
6COPI coating of Golgi vesicle (GO:0048205)5.41075212
7aromatic amino acid family catabolic process (GO:0009074)5.07953075
8L-alpha-amino acid transmembrane transport (GO:1902475)4.97303824
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.96058811
10behavioral response to nicotine (GO:0035095)4.72401172
11intestinal cholesterol absorption (GO:0030299)4.66845653
12piRNA metabolic process (GO:0034587)4.58558101
13peptidyl-glutamic acid carboxylation (GO:0017187)4.39694975
14protein carboxylation (GO:0018214)4.39694975
15cysteine metabolic process (GO:0006534)4.24920672
16complement activation, alternative pathway (GO:0006957)4.21674917
17urea metabolic process (GO:0019627)4.19578109
18urea cycle (GO:0000050)4.19578109
19tryptophan catabolic process (GO:0006569)4.17605584
20indole-containing compound catabolic process (GO:0042436)4.17605584
21indolalkylamine catabolic process (GO:0046218)4.17605584
22tryptophan metabolic process (GO:0006568)4.15702972
23alpha-linolenic acid metabolic process (GO:0036109)4.14635190
24COPII vesicle coating (GO:0048208)4.11449976
25bile acid biosynthetic process (GO:0006699)4.08799436
26high-density lipoprotein particle remodeling (GO:0034375)4.06293750
27kynurenine metabolic process (GO:0070189)4.04864784
28phospholipid efflux (GO:0033700)4.03780535
29sulfur amino acid catabolic process (GO:0000098)3.92510324
30nitrogen cycle metabolic process (GO:0071941)3.85752768
31regulation of cholesterol homeostasis (GO:2000188)3.85191430
32regulation of triglyceride catabolic process (GO:0010896)3.85157678
33reverse cholesterol transport (GO:0043691)3.84510865
34glyoxylate metabolic process (GO:0046487)3.84011731
35lysine metabolic process (GO:0006553)3.82169644
36lysine catabolic process (GO:0006554)3.82169644
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.81921527
38intestinal absorption (GO:0050892)3.81598374
39endocrine pancreas development (GO:0031018)3.81085235
40plasma lipoprotein particle clearance (GO:0034381)3.80784975
41bile acid metabolic process (GO:0008206)3.80355263
42triglyceride homeostasis (GO:0070328)3.78729024
43acylglycerol homeostasis (GO:0055090)3.78729024
44plasma lipoprotein particle assembly (GO:0034377)3.78623483
45regulation of protein activation cascade (GO:2000257)3.78192581
46cellular biogenic amine catabolic process (GO:0042402)3.77069881
47amine catabolic process (GO:0009310)3.77069881
48tyrosine metabolic process (GO:0006570)3.77048250
49homocysteine metabolic process (GO:0050667)3.67817132
50negative regulation of fibrinolysis (GO:0051918)3.65146692
51aromatic amino acid family metabolic process (GO:0009072)3.64556758
52peptide hormone processing (GO:0016486)3.63268866
53plasma lipoprotein particle remodeling (GO:0034369)3.61055289
54protein-lipid complex remodeling (GO:0034368)3.61055289
55macromolecular complex remodeling (GO:0034367)3.61055289
56cholesterol efflux (GO:0033344)3.60895984
57regulation of cholesterol esterification (GO:0010872)3.59938862
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56517462
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.56517462
60NADH dehydrogenase complex assembly (GO:0010257)3.56517462
61male meiosis I (GO:0007141)3.56407908
62regulation of complement activation (GO:0030449)3.54574650
63synapsis (GO:0007129)3.54268827
64platelet dense granule organization (GO:0060155)3.53336843
65regulation of fibrinolysis (GO:0051917)3.52315863
66serine family amino acid catabolic process (GO:0009071)3.51971486
67drug transmembrane transport (GO:0006855)3.50711936
68L-fucose catabolic process (GO:0042355)3.48900375
69fucose catabolic process (GO:0019317)3.48900375
70L-fucose metabolic process (GO:0042354)3.48900375
71regulation of meiosis I (GO:0060631)3.48653469
72bile acid and bile salt transport (GO:0015721)3.48429915
73positive regulation of heat generation (GO:0031652)3.42537082
74negative regulation of cholesterol transport (GO:0032375)3.42040713
75negative regulation of sterol transport (GO:0032372)3.42040713
76cellular response to ATP (GO:0071318)3.39874456
77protein-lipid complex assembly (GO:0065005)3.38938733
78lipoprotein metabolic process (GO:0042157)3.36469774
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.34954260
80negative regulation of systemic arterial blood pressure (GO:0003085)3.34416285
81amino-acid betaine metabolic process (GO:0006577)3.34187168
82DNA methylation involved in gamete generation (GO:0043046)3.30004939
83magnesium ion transport (GO:0015693)3.29478927
84response to pheromone (GO:0019236)3.27049401
85indole-containing compound metabolic process (GO:0042430)3.26698438
86retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.24495196
87indolalkylamine metabolic process (GO:0006586)3.24133008
88macroautophagy (GO:0016236)3.23627619
89male meiosis (GO:0007140)3.21587229
90negative regulation of digestive system process (GO:0060457)3.19463331
91plasma lipoprotein particle organization (GO:0071827)3.19073685
92very-low-density lipoprotein particle assembly (GO:0034379)3.17854291
93alpha-amino acid catabolic process (GO:1901606)3.17244151
94positive regulation of prostaglandin secretion (GO:0032308)3.17226716
95phospholipid homeostasis (GO:0055091)3.16053812
96mitochondrial calcium ion transport (GO:0006851)3.15313271
97positive regulation of triglyceride lipase activity (GO:0061365)3.14027372
98positive regulation of lipoprotein lipase activity (GO:0051006)3.14027372
99cholesterol homeostasis (GO:0042632)3.11793150
100positive regulation of fatty acid biosynthetic process (GO:0045723)3.10999494
101low-density lipoprotein particle clearance (GO:0034383)3.10751280
102protoporphyrinogen IX metabolic process (GO:0046501)3.10034170
103sterol homeostasis (GO:0055092)3.09379396
104regulation of heat generation (GO:0031650)3.08346477
105water-soluble vitamin biosynthetic process (GO:0042364)3.06969258
106neural tube formation (GO:0001841)3.04505753
107positive regulation of triglyceride metabolic process (GO:0090208)3.04420644
108positive regulation of glycolytic process (GO:0045821)3.02968358
109protein complex biogenesis (GO:0070271)3.02859646
110positive regulation of lipid catabolic process (GO:0050996)3.02154710
111activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.02000627
112NAD biosynthetic process (GO:0009435)3.01448901
113regulation of bile acid biosynthetic process (GO:0070857)3.00278838
114protein-lipid complex subunit organization (GO:0071825)2.99872849
115coenzyme catabolic process (GO:0009109)2.96950927
116drug catabolic process (GO:0042737)2.96155579
117protein retention in ER lumen (GO:0006621)2.95294096
118drug transport (GO:0015893)2.94955431
119cellular modified amino acid catabolic process (GO:0042219)2.94559967
120cellular amino acid catabolic process (GO:0009063)2.93414543
121cellular ketone body metabolic process (GO:0046950)2.93287715
122positive regulation of meiosis (GO:0045836)2.93095574
123urate metabolic process (GO:0046415)2.91153894
124protein K11-linked deubiquitination (GO:0035871)2.90769402
125valine metabolic process (GO:0006573)2.90322297
126cofactor catabolic process (GO:0051187)2.89603278
127positive regulation of nuclease activity (GO:0032075)2.89507316
128fatty acid oxidation (GO:0019395)2.88815788
129glycine metabolic process (GO:0006544)2.88441727
130glutamate metabolic process (GO:0006536)2.87929918
131proline transport (GO:0015824)2.87666527
132cholesterol transport (GO:0030301)2.87202780
133negative regulation of mast cell activation (GO:0033004)2.86293994
134mitochondrial respiratory chain complex assembly (GO:0033108)2.84725219
135positive regulation of cAMP-mediated signaling (GO:0043950)2.82839293
136positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.82077620
137response to caffeine (GO:0031000)2.81465026
138detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.80219782
139alanine transport (GO:0032328)2.76194626
140regulation of fever generation (GO:0031620)2.75449927
141positive regulation of meiotic cell cycle (GO:0051446)2.73918914
142regulation of cytokine secretion involved in immune response (GO:0002739)2.72595769
143detection of light stimulus involved in visual perception (GO:0050908)2.66711249
144detection of light stimulus involved in sensory perception (GO:0050962)2.66711249
145oxidative demethylation (GO:0070989)2.66646080
146regulation of prostaglandin secretion (GO:0032306)2.64110735
147DNA deamination (GO:0045006)2.63739053
148regulation of vitamin D biosynthetic process (GO:0060556)2.62207382
149synaptic transmission, cholinergic (GO:0007271)2.60311468
150ubiquinone biosynthetic process (GO:0006744)2.60004205
151sulfation (GO:0051923)2.59536026
152positive regulation of fatty acid transport (GO:2000193)2.59103693
153ovulation from ovarian follicle (GO:0001542)2.58381554
154basic amino acid transport (GO:0015802)2.58009208
155regulation of chronic inflammatory response (GO:0002676)2.57055676
156glycerophospholipid catabolic process (GO:0046475)2.55015821
157regulation of posttranscriptional gene silencing (GO:0060147)2.53670862
158regulation of gene silencing by miRNA (GO:0060964)2.53670862
159regulation of gene silencing by RNA (GO:0060966)2.53670862
160kidney morphogenesis (GO:0060993)2.51979585
161positive regulation of defense response to virus by host (GO:0002230)2.51321322
162negative regulation of DNA-dependent DNA replication (GO:2000104)2.50382085
163pyrimidine-containing compound transmembrane transport (GO:0072531)2.50259265
164phosphatidylinositol acyl-chain remodeling (GO:0036149)2.49963768
165meiosis I (GO:0007127)2.49641131
166RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46981245
167positive regulation of icosanoid secretion (GO:0032305)2.46589330
168somatic hypermutation of immunoglobulin genes (GO:0016446)2.45525575
169somatic diversification of immune receptors via somatic mutation (GO:0002566)2.45525575
170protein K6-linked ubiquitination (GO:0085020)2.43178485
171benzene-containing compound metabolic process (GO:0042537)2.41321889
172vitamin biosynthetic process (GO:0009110)2.40498895
173mitochondrial calcium ion homeostasis (GO:0051560)2.38498020
174negative regulation of interleukin-1 beta production (GO:0032691)2.33799123
175multicellular organism reproduction (GO:0032504)2.32942582
176regulation of nuclear cell cycle DNA replication (GO:0033262)2.31336421
177spinal cord motor neuron differentiation (GO:0021522)2.31164890
178pseudouridine synthesis (GO:0001522)2.31087425
179double-strand break repair via homologous recombination (GO:0000724)2.30996096
180sphingoid metabolic process (GO:0046519)2.30588257
181recombinational repair (GO:0000725)2.29797928
182hydrogen peroxide biosynthetic process (GO:0050665)2.29529745
183prostate gland growth (GO:0060736)2.29479951
184photoreceptor cell maintenance (GO:0045494)2.28062655
185nicotinamide nucleotide biosynthetic process (GO:0019359)2.25078117
186pyridine nucleotide biosynthetic process (GO:0019363)2.25078117
187positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.24431940
188ubiquinone metabolic process (GO:0006743)2.23447268
189reciprocal DNA recombination (GO:0035825)2.22556194
190reciprocal meiotic recombination (GO:0007131)2.22556194
191otic vesicle formation (GO:0030916)2.21809183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.57109464
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.43417196
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.64751626
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.12773776
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.10262452
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.93755018
7GATA1_22025678_ChIP-Seq_K562_Human4.53909404
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.14066418
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.12714086
10ZNF274_21170338_ChIP-Seq_K562_Hela3.67088386
11VDR_22108803_ChIP-Seq_LS180_Human3.58207376
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.23825119
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.16552308
14IGF1R_20145208_ChIP-Seq_DFB_Human3.13241311
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.11324711
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.06064865
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.74525091
18GBX2_23144817_ChIP-Seq_PC3_Human2.71600138
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40737695
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.34628156
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31738606
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26233979
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.21650943
24TAF15_26573619_Chip-Seq_HEK293_Human2.18227152
25EWS_26573619_Chip-Seq_HEK293_Human2.14737597
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13887131
27P300_19829295_ChIP-Seq_ESCs_Human2.02401242
28FUS_26573619_Chip-Seq_HEK293_Human2.01052772
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99483063
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91728534
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90427361
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87268915
33ER_23166858_ChIP-Seq_MCF-7_Human1.84352624
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79228814
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79226653
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78045826
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76514144
38GATA1_19941826_ChIP-Seq_K562_Human1.76374366
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.72390753
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72390753
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71046579
42SOX2_27498859_Chip-Seq_STOMACH_Mouse1.69491746
43CLOCK_20551151_ChIP-Seq_293T_Human1.65238333
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62627564
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62343034
46BCAT_22108803_ChIP-Seq_LS180_Human1.61516199
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58480865
48NANOG_19829295_ChIP-Seq_ESCs_Human1.56253606
49SOX2_19829295_ChIP-Seq_ESCs_Human1.56253606
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55755376
51* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.54670970
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52987101
53EZH2_22144423_ChIP-Seq_EOC_Human1.51943219
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48560646
55CBP_20019798_ChIP-Seq_JUKART_Human1.48373484
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48373484
57IRF1_19129219_ChIP-ChIP_H3396_Human1.47958820
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47290743
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47116703
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45968753
61* FOXA2_19822575_ChIP-Seq_HepG2_Human1.45605652
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45430113
63* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44071562
64STAT3_23295773_ChIP-Seq_U87_Human1.43645191
65* EZH2_27294783_Chip-Seq_NPCs_Mouse1.40896027
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40170472
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39775045
68TCF4_23295773_ChIP-Seq_U87_Human1.38451525
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36940464
70* TP53_22573176_ChIP-Seq_HFKS_Human1.36083819
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.35359419
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35266632
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35001639
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34549911
75AR_25329375_ChIP-Seq_VCAP_Human1.33792888
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.33235619
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31869570
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.29847304
79* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29477407
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29277815
81* GATA1_19941827_ChIP-Seq_MEL_Mouse1.28800255
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.26571007
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26326931
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.26162099
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26062361
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24346466
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.24346466
88* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24205941
89* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24092962
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23179906
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22968628
92HOXB7_26014856_ChIP-Seq_BT474_Human1.22178223
93TCF4_22108803_ChIP-Seq_LS180_Human1.21211752
94* CRX_20693478_ChIP-Seq_RETINA_Mouse1.21053527
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20878289
96* HNF4A_19822575_ChIP-Seq_HepG2_Human1.19611381
97GATA4_25053715_ChIP-Seq_YYC3_Human1.19087046
98* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18365108
99* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17651708
100* FLI1_21867929_ChIP-Seq_TH2_Mouse1.16802722
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.16647853
102* SMAD4_21799915_ChIP-Seq_A2780_Human1.15516965
103MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14649645
104GATA2_19941826_ChIP-Seq_K562_Human1.14543850
105* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13914075
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.13635778
107MYC_18940864_ChIP-ChIP_HL60_Human1.13403156
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.12253383
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10938633
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.10080736
111AR_20517297_ChIP-Seq_VCAP_Human1.09802595
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.09396909
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.09367429
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09159558
115NCOR_22424771_ChIP-Seq_293T_Human1.08958813
116MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08450059
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07503756
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05930797
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05239400
120ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04331837
121* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04264528
122IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04233677
123RUNX2_22187159_ChIP-Seq_PCA_Human1.03878304
124* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03408517
125GATA6_25053715_ChIP-Seq_YYC3_Human1.03173385
126IRF8_21731497_ChIP-ChIP_J774_Mouse1.02738192
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.02727097
128SCL_19346495_ChIP-Seq_HPC-7_Human1.01611504
129* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01090107
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00821853
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00269910
132P53_22387025_ChIP-Seq_ESCs_Mouse0.99544463
133SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97926914
134* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97754854
135E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97578015
136CDX2_22108803_ChIP-Seq_LS180_Human0.97419774
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.96962248
138E2F1_18555785_Chip-Seq_ESCs_Mouse0.96758073
139AR_21572438_ChIP-Seq_LNCaP_Human0.96011687
140* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95756347
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95713401
142RNF2_27304074_Chip-Seq_NSC_Mouse0.95458498
143* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94429524
144E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94374265
145POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94252719
146BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93051826
147PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93048675
148TFEB_21752829_ChIP-Seq_HELA_Human0.92669564
149SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92215397
150RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91682143
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89752798
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88540205
153THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87683193
154* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87001982
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86474926
156ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85475211
157TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83582922
158FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82576593
159CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80740276
160FOXO3_23340844_ChIP-Seq_DLD1_Human0.79724338
161LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79101654
162CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78105543
163TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78103634
164LXR_22292898_ChIP-Seq_THP-1_Human0.77386006
165PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75777255
166EGR1_19374776_ChIP-ChIP_THP-1_Human0.74576387
167RXRA_24833708_ChIP-Seq_LIVER_Mouse0.74156981
168GATA3_27048872_Chip-Seq_THYMUS_Human0.73968761
169RARA_24833708_ChIP-Seq_LIVER_Mouse0.73278221
170SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72046373
171MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.71981587
172ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.71789326
173LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.70235740
174DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70086509
175ERG_20517297_ChIP-Seq_VCAP_Human0.69784332
176ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69680225
177SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68895197
178CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68892322
179ESR1_21235772_ChIP-Seq_MCF-7_Human0.68705407
180CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67585232
181KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.66313826
182TCF7_22412390_ChIP-Seq_EML_Mouse0.66155364
183* PU_27001747_Chip-Seq_BMDM_Mouse0.65075642
184NCOR1_26117541_ChIP-Seq_K562_Human0.64991942
185GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.64651004
186* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63410058
187SPI1_23127762_ChIP-Seq_K562_Human0.63063247
188PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62567078
189* HTT_18923047_ChIP-ChIP_STHdh_Human0.62273718
190* SOX2_20726797_ChIP-Seq_SW620_Human0.61274539
191* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.61177239
192UTX_26944678_Chip-Seq_JUKART_Human0.61119263
193RARB_24833708_ChIP-Seq_LIVER_Mouse0.61007437
194GATA3_26560356_Chip-Seq_TH2_Human0.60638191
195MYB_26560356_Chip-Seq_TH1_Human0.59646222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.32810818
2MP0005360_urolithiasis5.48843869
3MP0003646_muscle_fatigue4.88472437
4MP0005365_abnormal_bile_salt4.75610597
5MP0005085_abnormal_gallbladder_physiolo4.53634992
6MP0003195_calcinosis4.23858033
7MP0003252_abnormal_bile_duct3.60225733
8MP0008875_abnormal_xenobiotic_pharmacok3.41522817
9MP0009840_abnormal_foam_cell3.41023151
10MP0008877_abnormal_DNA_methylation2.89155438
11MP0003806_abnormal_nucleotide_metabolis2.73295219
12MP0005083_abnormal_biliary_tract2.73123506
13MP0002877_abnormal_melanocyte_morpholog2.69087431
14MP0010329_abnormal_lipoprotein_level2.67820408
15MP0001666_abnormal_nutrient_absorption2.52123769
16MP0003183_abnormal_peptide_metabolism2.42522334
17MP0005167_abnormal_blood-brain_barrier2.36445488
18MP0002138_abnormal_hepatobiliary_system2.32740944
19MP0003656_abnormal_erythrocyte_physiolo2.20072114
20MP0002693_abnormal_pancreas_physiology2.02333895
21MP0004043_abnormal_pH_regulation2.01963287
22MP0003191_abnormal_cellular_cholesterol2.01207774
23MP0005332_abnormal_amino_acid2.00908661
24MP0000609_abnormal_liver_physiology2.00669845
25MP0002148_abnormal_hypersensitivity_rea1.97402892
26MP0004145_abnormal_muscle_electrophysio1.91084127
27MP0005645_abnormal_hypothalamus_physiol1.90296125
28MP0001944_abnormal_pancreas_morphology1.86497970
29MP0009046_muscle_twitch1.85693271
30MP0005551_abnormal_eye_electrophysiolog1.83830303
31MP0001501_abnormal_sleep_pattern1.81948967
32MP0003868_abnormal_feces_composition1.81900474
33MP0002118_abnormal_lipid_homeostasis1.79070868
34MP0000569_abnormal_digit_pigmentation1.78278774
35MP0005058_abnormal_lysosome_morphology1.76342458
36MP0002102_abnormal_ear_morphology1.76279522
37MP0003300_gastrointestinal_ulcer1.76190842
38MP0009643_abnormal_urine_homeostasis1.73733298
39MP0002078_abnormal_glucose_homeostasis1.68922313
40MP0002909_abnormal_adrenal_gland1.68779985
41MP0000013_abnormal_adipose_tissue1.67848609
42MP0002277_abnormal_respiratory_mucosa1.66802925
43MP0000372_irregular_coat_pigmentation1.64723906
44MP0004019_abnormal_vitamin_homeostasis1.64219279
45MP0005220_abnormal_exocrine_pancreas1.63820078
46MP0003136_yellow_coat_color1.60178857
47MP0005646_abnormal_pituitary_gland1.59438769
48MP0000383_abnormal_hair_follicle1.55991249
49MP0005174_abnormal_tail_pigmentation1.55382566
50MP0005319_abnormal_enzyme/_coenzyme1.55323734
51MP0005379_endocrine/exocrine_gland_phen1.54808332
52MP0000427_abnormal_hair_cycle1.50498940
53MP0002876_abnormal_thyroid_physiology1.50113159
54MP0005636_abnormal_mineral_homeostasis1.41406213
55MP0005253_abnormal_eye_physiology1.39289209
56MP0005671_abnormal_response_to1.34792870
57MP0004264_abnormal_extraembryonic_tissu1.34407692
58MP0001764_abnormal_homeostasis1.33963449
59MP0004742_abnormal_vestibular_system1.33055350
60MP0003172_abnormal_lysosome_physiology1.31023274
61MP0002653_abnormal_ependyma_morphology1.27400813
62MP0009780_abnormal_chondrocyte_physiolo1.26339876
63MP0002837_dystrophic_cardiac_calcinosis1.26180738
64MP0009745_abnormal_behavioral_response1.25417464
65MP0005310_abnormal_salivary_gland1.22074826
66MP0004142_abnormal_muscle_tone1.21765719
67MP0008872_abnormal_physiological_respon1.21480910
68MP0004510_myositis1.21128297
69MP0002638_abnormal_pupillary_reflex1.20129683
70MP0005410_abnormal_fertilization1.18097894
71MP0005389_reproductive_system_phenotype1.18060439
72MP0001485_abnormal_pinna_reflex1.16814808
73MP0001756_abnormal_urination1.16777815
74MP0002160_abnormal_reproductive_system1.16119957
75MP0008469_abnormal_protein_level1.14649237
76MP0005584_abnormal_enzyme/coenzyme_acti1.13692417
77MP0000598_abnormal_liver_morphology1.12782996
78MP0005647_abnormal_sex_gland1.11019716
79MP0002095_abnormal_skin_pigmentation1.10238531
80MP0002928_abnormal_bile_duct1.09822299
81MP0004215_abnormal_myocardial_fiber1.09552867
82MP0002938_white_spotting1.08919756
83MP0006072_abnormal_retinal_apoptosis1.08246409
84MP0005670_abnormal_white_adipose1.08002250
85MP0003436_decreased_susceptibility_to1.07490127
86MP0000003_abnormal_adipose_tissue1.07029028
87MP0002332_abnormal_exercise_endurance1.06510517
88MP0002064_seizures1.06088745
89MP0003186_abnormal_redox_activity1.03078688
90MP0008057_abnormal_DNA_replication1.02962353
91MP0005408_hypopigmentation1.00820754
92MP0009642_abnormal_blood_homeostasis1.00794928
93MP0001919_abnormal_reproductive_system1.00471298
94MP0000631_abnormal_neuroendocrine_gland0.99709584
95MP0000604_amyloidosis0.99167896
96MP0001765_abnormal_ion_homeostasis0.99143500
97MP0004147_increased_porphyrin_level0.96758099
98MP0001324_abnormal_eye_pigmentation0.95021806
99MP0000371_diluted_coat_color0.94744270
100MP0003718_maternal_effect0.94412375
101MP0002210_abnormal_sex_determination0.94101320
102MP0005334_abnormal_fat_pad0.94015096
103MP0009763_increased_sensitivity_to0.93941315
104MP0005464_abnormal_platelet_physiology0.93878445
105MP0000678_abnormal_parathyroid_gland0.93344424
106MP0003698_abnormal_male_reproductive0.92509438
107MP0003303_peritoneal_inflammation0.92180381
108MP0003283_abnormal_digestive_organ0.90431257
109MP0005535_abnormal_body_temperature0.90085361
110MP0005448_abnormal_energy_balance0.89719083
111MP0003953_abnormal_hormone_level0.88838272
112MP0009764_decreased_sensitivity_to0.88586096
113MP0001929_abnormal_gametogenesis0.88250469
114MP0002163_abnormal_gland_morphology0.88029932
115MP0001968_abnormal_touch/_nociception0.85202061
116MP0005084_abnormal_gallbladder_morpholo0.84009623
117MP0000647_abnormal_sebaceous_gland0.83649029
118MP0004130_abnormal_muscle_cell0.82944235
119MP0010678_abnormal_skin_adnexa0.80750387
120MP0003724_increased_susceptibility_to0.80651808
121MP0005386_behavior/neurological_phenoty0.80027352
122MP0004924_abnormal_behavior0.80027352
123MP0009697_abnormal_copulation0.78904227
124MP0006036_abnormal_mitochondrial_physio0.78236856
125MP0008961_abnormal_basal_metabolism0.78188057
126MP0010386_abnormal_urinary_bladder0.78029615
127MP0005375_adipose_tissue_phenotype0.77016033
128MP0002971_abnormal_brown_adipose0.77005296
129MP0004947_skin_inflammation0.76730247
130MP0002229_neurodegeneration0.75475183
131MP0001845_abnormal_inflammatory_respons0.75373405
132MP0000653_abnormal_sex_gland0.75306960
133MP0003959_abnormal_lean_body0.75257428
134MP0006292_abnormal_olfactory_placode0.73807644
135MP0001145_abnormal_male_reproductive0.72045060
136MP0002272_abnormal_nervous_system0.71857285
137MP0003137_abnormal_impulse_conducting0.71419328
138MP0006054_spinal_hemorrhage0.71224539
139MP0002733_abnormal_thermal_nociception0.70538726
140MP0003705_abnormal_hypodermis_morpholog0.69844078
141MP0005195_abnormal_posterior_eye0.69290270
142MP0000015_abnormal_ear_pigmentation0.69215820
143MP0002136_abnormal_kidney_physiology0.67466000
144MP0001800_abnormal_humoral_immune0.66685248
145MP0001970_abnormal_pain_threshold0.64744672
146MP0002419_abnormal_innate_immunity0.64368238
147MP0006082_CNS_inflammation0.64213534
148MP0009765_abnormal_xenobiotic_induced0.62914984
149MP0002896_abnormal_bone_mineralization0.62185755
150MP0000639_abnormal_adrenal_gland0.61863149
151MP0005666_abnormal_adipose_tissue0.60105782
152MP0000230_abnormal_systemic_arterial0.59067412
153MP0001533_abnormal_skeleton_physiology0.56196682
154MP0005451_abnormal_body_composition0.56158595
155MP0002970_abnormal_white_adipose0.55360754
156MP0005376_homeostasis/metabolism_phenot0.53775038
157MP0009672_abnormal_birth_weight0.52666629
158MP0005025_abnormal_response_to0.51486871
159MP0001661_extended_life_span0.50130557
160MP0004185_abnormal_adipocyte_glucose0.50116324
161MP0005266_abnormal_metabolism0.47863156
162MP0005387_immune_system_phenotype0.47847043
163MP0001790_abnormal_immune_system0.47847043
164MP0003075_altered_response_to0.46774990
165MP0002254_reproductive_system_inflammat0.46693916
166MP0009785_altered_susceptibility_to0.46427197

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.84973398
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.76841533
3Hyperinsulinemic hypoglycemia (HP:0000825)5.45240883
4Intrahepatic cholestasis (HP:0001406)5.43936296
5Hypoglycemic seizures (HP:0002173)5.29499132
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.86432196
7Xanthomatosis (HP:0000991)4.77284949
8Ketoacidosis (HP:0001993)4.47312390
9Symptomatic seizures (HP:0011145)4.41179651
10Deep venous thrombosis (HP:0002625)4.36903143
11Prolonged partial thromboplastin time (HP:0003645)4.26254453
12Ketosis (HP:0001946)4.16403483
13Hypobetalipoproteinemia (HP:0003563)4.11584816
14Pancreatic cysts (HP:0001737)4.03813848
15Hyperglycemia (HP:0003074)4.01409480
16Abnormality of the common coagulation pathway (HP:0010990)4.01166078
17Conjugated hyperbilirubinemia (HP:0002908)3.97296412
18Abnormality of the intrinsic pathway (HP:0010989)3.92527797
19Complement deficiency (HP:0004431)3.90031428
20Late onset (HP:0003584)3.72006331
21Abnormality of midbrain morphology (HP:0002418)3.56904929
22Molar tooth sign on MRI (HP:0002419)3.56904929
23Pancreatic islet-cell hyperplasia (HP:0004510)3.50894881
24Abnormality of endocrine pancreas physiology (HP:0012093)3.48460454
25Abnormality of the pancreatic islet cells (HP:0006476)3.48460454
26Hyperlipoproteinemia (HP:0010980)3.45569140
27Epidermoid cyst (HP:0200040)3.43096041
28Joint hemorrhage (HP:0005261)3.39510221
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.31879842
30Hyperbilirubinemia (HP:0002904)3.27643120
31Abnormality of alanine metabolism (HP:0010916)3.24761746
32Hyperalaninemia (HP:0003348)3.24761746
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.24761746
34Hypolipoproteinemia (HP:0010981)3.20850364
35Acanthocytosis (HP:0001927)3.18370639
36Pancreatic fibrosis (HP:0100732)3.12913512
37Fat malabsorption (HP:0002630)3.12037668
38True hermaphroditism (HP:0010459)3.06063059
39Abnormality of glutamine family amino acid metabolism (HP:0010902)3.04647949
40Polydipsia (HP:0001959)3.00949279
41Abnormal drinking behavior (HP:0030082)3.00949279
42Skin nodule (HP:0200036)3.00785663
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.98749281
44Congenital stationary night blindness (HP:0007642)2.98723401
45Mucopolysacchariduria (HP:0008155)2.95947719
46Urinary glycosaminoglycan excretion (HP:0003541)2.95947719
47Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.95870536
48Insulin-resistant diabetes mellitus (HP:0000831)2.95638812
49Poikilocytosis (HP:0004447)2.94620564
50Inability to walk (HP:0002540)2.93876739
51Generalized aminoaciduria (HP:0002909)2.90093763
52Abnormality of complement system (HP:0005339)2.89892063
53Nephronophthisis (HP:0000090)2.89174842
54Hyperammonemia (HP:0001987)2.85881425
55Recurrent gram-negative bacterial infections (HP:0005420)2.83509490
56Hypoalphalipoproteinemia (HP:0003233)2.83294378
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.82246021
58Abnormality of glycolipid metabolism (HP:0010969)2.82246021
59Abnormality of liposaccharide metabolism (HP:0010968)2.82246021
60Abnormality of purine metabolism (HP:0004352)2.81427384
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.81345903
62Dysostosis multiplex (HP:0000943)2.80674225
63Pendular nystagmus (HP:0012043)2.79765081
64Type II lissencephaly (HP:0007260)2.79703044
65Mutism (HP:0002300)2.79359898
66Hypercholesterolemia (HP:0003124)2.77888253
67Chronic hepatic failure (HP:0100626)2.77541598
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.76112085
69Hyperventilation (HP:0002883)2.75575884
70Abnormality of polysaccharide metabolism (HP:0011012)2.73909924
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.73909924
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.73909924
73Abnormality of the renal cortex (HP:0011035)2.72987937
74Abnormal gallbladder morphology (HP:0012437)2.64702477
75Abolished electroretinogram (ERG) (HP:0000550)2.60478251
76Stomatitis (HP:0010280)2.58483898
77Hyperglycinemia (HP:0002154)2.58268249
78Hyperglycinuria (HP:0003108)2.57541980
79Abnormality of nucleobase metabolism (HP:0010932)2.56959395
80Systemic lupus erythematosus (HP:0002725)2.54005369
81Tubular atrophy (HP:0000092)2.51562668
82Abnormality of the renal medulla (HP:0100957)2.50160969
83Myocardial infarction (HP:0001658)2.50014077
84Attenuation of retinal blood vessels (HP:0007843)2.49075592
85Increased cerebral lipofuscin (HP:0011813)2.48794944
86Hepatocellular carcinoma (HP:0001402)2.48498144
87Retinal atrophy (HP:0001105)2.44808127
88Abnormality of aspartate family amino acid metabolism (HP:0010899)2.44167787
89Abnormality of fatty-acid metabolism (HP:0004359)2.42029302
90Large for gestational age (HP:0001520)2.40251760
91Insulin resistance (HP:0000855)2.39680654
92Hypochromic microcytic anemia (HP:0004840)2.38418397
93Abnormality of methionine metabolism (HP:0010901)2.35845100
94Gout (HP:0001997)2.35016830
95Abnormality of glycine metabolism (HP:0010895)2.33544257
96Abnormality of serine family amino acid metabolism (HP:0010894)2.33544257
97Cholelithiasis (HP:0001081)2.32300409
98Progressive inability to walk (HP:0002505)2.32165761
99Global brain atrophy (HP:0002283)2.30463720
100Polyuria (HP:0000103)2.28970335
101Vacuolated lymphocytes (HP:0001922)2.25351592
102Hypomagnesemia (HP:0002917)2.24536975
103Metabolic acidosis (HP:0001942)2.20988720
104Irritability (HP:0000737)2.20692868
105Pancreatitis (HP:0001733)2.18809591
106Hypophosphatemia (HP:0002148)2.18162626
107Protuberant abdomen (HP:0001538)2.17948608
108Calf muscle hypertrophy (HP:0008981)2.17583648
109Muscle hypertrophy of the lower extremities (HP:0008968)2.16708238
110Gaze-evoked nystagmus (HP:0000640)2.16595752
111Abnormal rod and cone electroretinograms (HP:0008323)2.16141600
112Clumsiness (HP:0002312)2.15155027
113Congenital sensorineural hearing impairment (HP:0008527)2.14754161
114Decreased central vision (HP:0007663)2.14298563
115Reticulocytosis (HP:0001923)2.13293520
116Medial flaring of the eyebrow (HP:0010747)2.12799079
117Abnormal enzyme/coenzyme activity (HP:0012379)2.11614354
118Osteomalacia (HP:0002749)2.11574571
119Elevated alkaline phosphatase (HP:0003155)2.11231241
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10822186
121Abnormality of pyrimidine metabolism (HP:0004353)2.08023416
122Glomerulonephritis (HP:0000099)2.07205059
123Anencephaly (HP:0002323)2.06147322
124Tetany (HP:0001281)2.05761865
125Protruding tongue (HP:0010808)2.05294565
126Abnormality of calcium-phosphate metabolism (HP:0100530)2.05125339
127Abdominal distention (HP:0003270)2.03405423
128Abnormality of the gallbladder (HP:0005264)2.02680583
129Fair hair (HP:0002286)2.02594997
130Bilateral microphthalmos (HP:0007633)2.01550798
131Abnormality of alkaline phosphatase activity (HP:0004379)1.99634472
132Male pseudohermaphroditism (HP:0000037)1.96416711
133Colon cancer (HP:0003003)1.96245267
134Cystic liver disease (HP:0006706)1.95571123
135Congenital hepatic fibrosis (HP:0002612)1.94441393
136Mitral stenosis (HP:0001718)1.94398584
137Menorrhagia (HP:0000132)1.94040124
138Progressive cerebellar ataxia (HP:0002073)1.93217179
139Abnormality of transition element cation homeostasis (HP:0011030)1.92642449
140Glycosuria (HP:0003076)1.92142692
141Abnormality of urine glucose concentration (HP:0011016)1.92142692
142Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91412490
143Hypothermia (HP:0002045)1.90718716
144Abnormal gallbladder physiology (HP:0012438)1.89756171
145Cholecystitis (HP:0001082)1.89756171
146Bile duct proliferation (HP:0001408)1.89708579
147Abnormal biliary tract physiology (HP:0012439)1.89708579
148Inappropriate behavior (HP:0000719)1.89400198
149Limb hypertonia (HP:0002509)1.88468263
150Thyroid-stimulating hormone excess (HP:0002925)1.87871530
151Broad-based gait (HP:0002136)1.87110120
152Genetic anticipation (HP:0003743)1.86738026
153Death in childhood (HP:0003819)1.86112042
154Methylmalonic aciduria (HP:0012120)1.85696633
155Abnormal urine output (HP:0012590)1.85257260
156Increased corneal curvature (HP:0100692)1.84871692
157Keratoconus (HP:0000563)1.84871692
158Dialeptic seizures (HP:0011146)1.84576796
159Furrowed tongue (HP:0000221)1.82822592
1603-Methylglutaconic aciduria (HP:0003535)1.82727756
161Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81881454
162Steatorrhea (HP:0002570)1.80892353
163Disinhibition (HP:0000734)1.80517402
164Abnormality of proline metabolism (HP:0010907)1.79344859
165Hydroxyprolinuria (HP:0003080)1.79344859
166Dicarboxylic aciduria (HP:0003215)1.78786236
167Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78786236
168Brushfield spots (HP:0001088)1.78640421
169Widely spaced teeth (HP:0000687)1.74640293
170Abnormality of the pons (HP:0007361)1.74439571
171Sclerocornea (HP:0000647)1.73430675
172Genital tract atresia (HP:0001827)1.72770448
173Febrile seizures (HP:0002373)1.71795673
174Increased CSF lactate (HP:0002490)1.70812475
175Decreased circulating renin level (HP:0003351)1.70457238
176Hypoplasia of the pons (HP:0012110)1.69338764
177Vaginal atresia (HP:0000148)1.69213575
178Tubulointerstitial fibrosis (HP:0005576)1.67625065
179Dynein arm defect of respiratory motile cilia (HP:0012255)1.66287536
180Absent/shortened dynein arms (HP:0200106)1.66287536
181Azoospermia (HP:0000027)1.63121499
182Aplasia/Hypoplasia of the uvula (HP:0010293)1.62445615
183Stomach cancer (HP:0012126)1.61977149
184Agnosia (HP:0010524)1.60715267
185Congenital, generalized hypertrichosis (HP:0004540)1.59323523
186Cerebellar dysplasia (HP:0007033)1.59075879
187Aplasia/Hypoplasia of the tongue (HP:0010295)1.58841126
188Abnormality of renal excretion (HP:0011036)1.58750085
189Hypoplastic iliac wings (HP:0002866)1.58542111
190Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.58067374
191Abnormal protein N-linked glycosylation (HP:0012347)1.58067374
192Abnormal protein glycosylation (HP:0012346)1.58067374
193Abnormal glycosylation (HP:0012345)1.58067374
194Metaphyseal irregularity (HP:0003025)1.57452662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.43818208
2INSRR5.23774465
3ERN14.24659004
4ACVR1B4.12749998
5MAPK154.12453280
6ADRBK23.62793014
7PIK3CG3.04531169
8BMPR1B2.79741276
9BCKDK2.65081714
10OBSCN2.64475205
11IRAK32.57450558
12FRK2.52713635
13WNK32.41104099
14TRIB32.30980085
15FLT32.26440787
16ZAK2.23478541
17PASK2.22829697
18NUAK12.13348507
19FGFR42.06417348
20TLK12.05440344
21TNIK1.99189836
22SIK11.98492503
23PTK61.97940063
24TAF11.90259146
25VRK21.83561126
26GRK11.79116121
27TYK21.75482319
28HIPK21.74660234
29PINK11.69617376
30PNCK1.67909831
31PHKG21.65040037
32PHKG11.65040037
33PKN21.62771857
34SCYL21.60424053
35MAP4K21.58673742
36MAP3K21.54646927
37TBK11.50713542
38CASK1.48137639
39GRK71.47292144
40VRK11.46460640
41JAK21.42717971
42BLK1.41206416
43MAP3K11.39239383
44WNK41.29907794
45TGFBR11.29505677
46MAP3K101.27040141
47TXK1.26949084
48JAK11.26570526
49MAP3K41.19440095
50RIPK11.17386819
51STK38L1.14989538
52DAPK21.09560620
53MAPK131.05523210
54PRKD31.05401241
55MATK1.05151010
56DYRK1B1.04255899
57ERBB41.02458525
58MKNK21.01326684
59OXSR11.01011448
60MAP2K61.00975837
61BRSK20.97907180
62EPHA30.96970475
63MAPK110.96806336
64STK390.96802285
65STK30.96353908
66CSK0.95178102
67DYRK30.95084587
68NEK90.91472903
69CSNK1G10.89285146
70CSNK1G20.88592011
71JAK30.87907946
72MAP3K30.87072076
73AKT30.85874075
74STK240.85873223
75MAP3K140.85863813
76MST1R0.84759183
77TYRO30.84539111
78CAMKK20.82990948
79TRIM280.82873073
80ZAP700.82825774
81IKBKE0.81139752
82CSNK1G30.80200693
83EIF2AK20.79382877
84WEE10.79212092
85PTK20.79173037
86PRKCG0.79106073
87LATS10.78972954
88MAPKAPK50.76868219
89CAMK1D0.75826153
90PRKAA10.75502488
91IRAK40.74726357
92CAMK40.73921194
93PDGFRA0.70914282
94CSNK1A1L0.70017210
95MARK30.69225328
96MAP2K30.68487280
97PRKCH0.68294174
98PKN10.66526623
99MAP4K10.65964602
100PRKAA20.65385461
101CDK60.64139351
102CAMK10.63008856
103MAP2K70.61559215
104DYRK20.60970716
105FGR0.60485986
106ITK0.59227234
107CHUK0.58676860
108IRAK10.58620766
109SGK20.58156387
110STK160.57513369
111MET0.57307644
112CHEK20.57180329
113EPHB10.56703116
114KIT0.56017690
115ADRBK10.56006195
116MAP2K20.55545114
117PRKCE0.54690154
118MTOR0.53930064
119GSK3A0.53115119
120FGFR20.51925973
121BTK0.51826269
122UHMK10.50907189
123ERBB30.50780970
124PRKACG0.50607113
125PLK40.50118604
126RPS6KA60.49785595
127ABL20.48989420
128FGFR30.47970508
129CSNK1A10.46909751
130MKNK10.45470745
131MAP3K50.45038862
132KDR0.43581054
133RET0.43366174
134CDK120.41591722
135EIF2AK30.40485325
136STK110.38965777
137TEC0.38240824
138SYK0.37914928
139PDPK10.36772882
140SGK30.36709713
141ERBB20.35753325
142MAPKAPK30.35518213
143MAP3K110.35273194
144PLK20.35220796
145RPS6KA50.35177122
146RPS6KA40.35156847
147CAMK2A0.34908480
148TGFBR20.34836572
149CSNK1D0.33374734
150CDC42BPA0.33143643
151CAMK1G0.33116915
152GRK60.32806665
153CLK10.32698776
154PRKCQ0.32387333
155IGF1R0.32304938
156LYN0.31712761
157EGFR0.31076143
158CDK40.30197372
159EIF2AK10.30104945
160SGK10.29329255
161PAK30.28450666
162PRKD20.27870555
163IKBKB0.27833867
164STK40.26796773
165TAOK10.24755928
166STK100.24301478
167KSR20.24004124
168PIM10.23767519
169BRD40.23153313
170NLK0.22692884
171PRKG20.22214160

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.11324427
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.65355883
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.60351133
4Nitrogen metabolism_Homo sapiens_hsa009102.93059412
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.81484104
6Tryptophan metabolism_Homo sapiens_hsa003802.62327327
7Arginine biosynthesis_Homo sapiens_hsa002202.40899364
8Sulfur metabolism_Homo sapiens_hsa009202.31618332
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30570813
10Selenocompound metabolism_Homo sapiens_hsa004502.30108270
11Complement and coagulation cascades_Homo sapiens_hsa046102.29931547
12Phototransduction_Homo sapiens_hsa047442.25855815
13Fatty acid degradation_Homo sapiens_hsa000712.18182650
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01583893
15Ether lipid metabolism_Homo sapiens_hsa005651.95988757
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95638054
17Homologous recombination_Homo sapiens_hsa034401.95567062
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94099975
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88900629
20Staphylococcus aureus infection_Homo sapiens_hsa051501.86506042
21Caffeine metabolism_Homo sapiens_hsa002321.86153256
22ABC transporters_Homo sapiens_hsa020101.85277377
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84781605
24Folate biosynthesis_Homo sapiens_hsa007901.82553038
25Rheumatoid arthritis_Homo sapiens_hsa053231.81179441
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.79376883
27Peroxisome_Homo sapiens_hsa041461.76939689
28Fat digestion and absorption_Homo sapiens_hsa049751.73035401
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71712512
30Histidine metabolism_Homo sapiens_hsa003401.70061670
31Oxidative phosphorylation_Homo sapiens_hsa001901.68279200
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66948742
33Starch and sucrose metabolism_Homo sapiens_hsa005001.65395696
34Butanoate metabolism_Homo sapiens_hsa006501.64148559
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.62177147
36Asthma_Homo sapiens_hsa053101.61889037
37Basal transcription factors_Homo sapiens_hsa030221.60238290
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.57578133
39Protein export_Homo sapiens_hsa030601.55797482
40PPAR signaling pathway_Homo sapiens_hsa033201.54069771
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51307524
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50103277
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47753732
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45156463
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44535347
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41788693
47Fatty acid metabolism_Homo sapiens_hsa012121.37035192
48Bile secretion_Homo sapiens_hsa049761.35723021
49Phenylalanine metabolism_Homo sapiens_hsa003601.32338593
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32160296
51beta-Alanine metabolism_Homo sapiens_hsa004101.30975441
52Fanconi anemia pathway_Homo sapiens_hsa034601.26643129
53RNA degradation_Homo sapiens_hsa030181.23916519
54Propanoate metabolism_Homo sapiens_hsa006401.22687119
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21906258
56NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21179440
57Collecting duct acid secretion_Homo sapiens_hsa049661.20371711
58Mineral absorption_Homo sapiens_hsa049781.19963092
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19440803
60RNA polymerase_Homo sapiens_hsa030201.19001046
61Chemical carcinogenesis_Homo sapiens_hsa052041.18166498
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.17811406
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16929428
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13864768
65NF-kappa B signaling pathway_Homo sapiens_hsa040641.11521267
66Glycosaminoglycan degradation_Homo sapiens_hsa005311.11071783
67Sphingolipid metabolism_Homo sapiens_hsa006001.10577773
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10524099
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08437147
70Type II diabetes mellitus_Homo sapiens_hsa049301.07340407
71Tyrosine metabolism_Homo sapiens_hsa003501.02686566
72Lysine degradation_Homo sapiens_hsa003101.00655449
73Retinol metabolism_Homo sapiens_hsa008300.97501049
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97314590
75Lysosome_Homo sapiens_hsa041420.94874191
76Allograft rejection_Homo sapiens_hsa053300.94489116
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94316635
78Vitamin digestion and absorption_Homo sapiens_hsa049770.91461594
79Arachidonic acid metabolism_Homo sapiens_hsa005900.91120928
80Nicotine addiction_Homo sapiens_hsa050330.87924975
81Parkinsons disease_Homo sapiens_hsa050120.85893018
82Insulin resistance_Homo sapiens_hsa049310.85788723
83TNF signaling pathway_Homo sapiens_hsa046680.84038042
84Graft-versus-host disease_Homo sapiens_hsa053320.81956834
85Pyruvate metabolism_Homo sapiens_hsa006200.81817296
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80258447
87African trypanosomiasis_Homo sapiens_hsa051430.79033860
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77360890
89Galactose metabolism_Homo sapiens_hsa000520.77272440
90Type I diabetes mellitus_Homo sapiens_hsa049400.75748899
91Sulfur relay system_Homo sapiens_hsa041220.73130406
92Carbon metabolism_Homo sapiens_hsa012000.72372304
93Insulin secretion_Homo sapiens_hsa049110.71316689
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.71263984
95One carbon pool by folate_Homo sapiens_hsa006700.69658256
96Prion diseases_Homo sapiens_hsa050200.69532246
97Dorso-ventral axis formation_Homo sapiens_hsa043200.69005608
98Arginine and proline metabolism_Homo sapiens_hsa003300.67129569
99Fatty acid elongation_Homo sapiens_hsa000620.65796785
100Ovarian steroidogenesis_Homo sapiens_hsa049130.65402252
101Other glycan degradation_Homo sapiens_hsa005110.64252628
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64018519
103Cardiac muscle contraction_Homo sapiens_hsa042600.62213089
104Biosynthesis of amino acids_Homo sapiens_hsa012300.62140707
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59305363
106Olfactory transduction_Homo sapiens_hsa047400.58675645
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57113509
108Huntingtons disease_Homo sapiens_hsa050160.56993225
109Alzheimers disease_Homo sapiens_hsa050100.54320110
110Steroid biosynthesis_Homo sapiens_hsa001000.54032596
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.54002392
112Autoimmune thyroid disease_Homo sapiens_hsa053200.53595381
113Osteoclast differentiation_Homo sapiens_hsa043800.51767295
114Renin-angiotensin system_Homo sapiens_hsa046140.51452445
115Glucagon signaling pathway_Homo sapiens_hsa049220.51084538
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50552110
117Taste transduction_Homo sapiens_hsa047420.50125326
118Glycerolipid metabolism_Homo sapiens_hsa005610.49476287
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48964532
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47779561
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46576882
122Legionellosis_Homo sapiens_hsa051340.46020382
123Tuberculosis_Homo sapiens_hsa051520.43783462
124Purine metabolism_Homo sapiens_hsa002300.42780602
125N-Glycan biosynthesis_Homo sapiens_hsa005100.42053337
126Pentose phosphate pathway_Homo sapiens_hsa000300.41824638
127Glutathione metabolism_Homo sapiens_hsa004800.38488357
128Fatty acid biosynthesis_Homo sapiens_hsa000610.38164912
129Serotonergic synapse_Homo sapiens_hsa047260.37905419
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37486321
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35616155
132Vitamin B6 metabolism_Homo sapiens_hsa007500.35033179
133Linoleic acid metabolism_Homo sapiens_hsa005910.34367505
134Metabolic pathways_Homo sapiens_hsa011000.32445980
135Fructose and mannose metabolism_Homo sapiens_hsa000510.32260212
136Regulation of autophagy_Homo sapiens_hsa041400.29172228
137AMPK signaling pathway_Homo sapiens_hsa041520.21355340
138Insulin signaling pathway_Homo sapiens_hsa049100.20723367
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19042848
140Systemic lupus erythematosus_Homo sapiens_hsa053220.17122503
141Prolactin signaling pathway_Homo sapiens_hsa049170.15958250
142Thyroid hormone synthesis_Homo sapiens_hsa049180.13418324
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12780713
144Pertussis_Homo sapiens_hsa051330.12497780
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.12430844
146Antigen processing and presentation_Homo sapiens_hsa046120.11580551
147Hepatitis C_Homo sapiens_hsa051600.11155034
148Circadian rhythm_Homo sapiens_hsa047100.09560810

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