SLC15A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.12456318
2vitamin A metabolic process (GO:0006776)8.05591834
3regulation of guanylate cyclase activity (GO:0031282)7.55108381
4adhesion of symbiont to host cell (GO:0044650)7.10666353
5virion attachment to host cell (GO:0019062)7.10666353
6positive regulation of guanylate cyclase activity (GO:0031284)6.09044703
7fat-soluble vitamin biosynthetic process (GO:0042362)6.02735664
8drinking behavior (GO:0042756)5.75009265
9oligosaccharide catabolic process (GO:0009313)5.70641119
10adhesion of symbiont to host (GO:0044406)5.52060327
11drug metabolic process (GO:0017144)5.41442166
12flavonoid metabolic process (GO:0009812)5.39610886
13phospholipid efflux (GO:0033700)5.34846113
14hormone catabolic process (GO:0042447)5.21735649
15NADH metabolic process (GO:0006734)5.14154383
16digestive system process (GO:0022600)5.08225724
17sulfate transmembrane transport (GO:1902358)5.00471903
18actin filament depolymerization (GO:0030042)4.99806716
19peptide hormone processing (GO:0016486)4.90569253
20exogenous drug catabolic process (GO:0042738)4.86922107
213-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.85243712
22purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.85243712
23sphingomyelin metabolic process (GO:0006684)4.82725924
24uronic acid metabolic process (GO:0006063)4.77822813
25glucuronate metabolic process (GO:0019585)4.77822813
26cellular glucuronidation (GO:0052695)4.76755686
27regulation of cGMP biosynthetic process (GO:0030826)4.70918939
28positive regulation of lipoprotein lipase activity (GO:0051006)4.61205675
29positive regulation of triglyceride lipase activity (GO:0061365)4.61205675
30fructose metabolic process (GO:0006000)4.60814357
31response to hepatocyte growth factor (GO:0035728)4.58251004
32cellular response to hepatocyte growth factor stimulus (GO:0035729)4.58251004
33alkaloid metabolic process (GO:0009820)4.56700855
34bile acid and bile salt transport (GO:0015721)4.55744783
35drug catabolic process (GO:0042737)4.54383269
36modified amino acid transport (GO:0072337)4.53256654
37peptide catabolic process (GO:0043171)4.49844547
38regulation of cholesterol esterification (GO:0010872)4.47135371
39very-low-density lipoprotein particle assembly (GO:0034379)4.45995800
40plasma lipoprotein particle assembly (GO:0034377)4.44766012
41sulfate transport (GO:0008272)4.40555197
42bundle of His cell to Purkinje myocyte communication (GO:0086069)4.40500892
43regulation of cellular extravasation (GO:0002691)4.33287452
44omega-hydroxylase P450 pathway (GO:0097267)4.27616524
45regulation of triglyceride catabolic process (GO:0010896)4.19783692
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.13822175
47lipoprotein metabolic process (GO:0042157)4.12149955
48cholesterol efflux (GO:0033344)4.09167043
49regulation of cGMP metabolic process (GO:0030823)4.04576989
50polyol transport (GO:0015791)4.01738031
51protein-lipid complex assembly (GO:0065005)4.00386741
52receptor guanylyl cyclase signaling pathway (GO:0007168)3.99361305
53* digestion (GO:0007586)3.98161111
54vitamin transport (GO:0051180)3.97712441
55transepithelial transport (GO:0070633)3.95856507
56arginine metabolic process (GO:0006525)3.95458770
57vitamin transmembrane transport (GO:0035461)3.94858139
58vitamin biosynthetic process (GO:0009110)3.91432549
59desmosome organization (GO:0002934)3.88269921
60renal system process involved in regulation of blood volume (GO:0001977)3.87888350
61regulation of systemic arterial blood pressure by hormone (GO:0001990)3.86412617
62regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.86412617
63endocrine process (GO:0050886)3.86412617
64sulfur compound transport (GO:0072348)3.82292149
65fat-soluble vitamin metabolic process (GO:0006775)3.81018925
66regulation of bile acid biosynthetic process (GO:0070857)3.76860506
67positive regulation of glycoprotein biosynthetic process (GO:0010560)3.76216010
68glucose 6-phosphate metabolic process (GO:0051156)3.75330463
69phospholipid scrambling (GO:0017121)3.69069817
70phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.69026705
71positive regulation of cGMP biosynthetic process (GO:0030828)3.65869500
72bile acid metabolic process (GO:0008206)3.62936023
73cobalamin metabolic process (GO:0009235)3.60928382
74quinone biosynthetic process (GO:1901663)3.57819721
75histamine secretion (GO:0001821)3.56100951
76maintenance of gastrointestinal epithelium (GO:0030277)3.54148503
77homocysteine metabolic process (GO:0050667)3.53895686
78phenylpropanoid metabolic process (GO:0009698)3.53428543
79cellular anion homeostasis (GO:0030002)3.52419515
80cytidine catabolic process (GO:0006216)3.51756950
81cytidine deamination (GO:0009972)3.51756950
82cytidine metabolic process (GO:0046087)3.51756950
83glycerol metabolic process (GO:0006071)3.50749286
84cholesterol transport (GO:0030301)3.50580188
85sterol transport (GO:0015918)3.50580188
86lipoprotein transport (GO:0042953)3.49841167
87adenosine metabolic process (GO:0046085)3.44062240
88negative regulation of keratinocyte proliferation (GO:0010839)3.41874259
89drug transmembrane transport (GO:0006855)3.40478642
90drug transport (GO:0015893)3.35436514
91auditory receptor cell differentiation (GO:0042491)3.34700967
92regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.32862859
93urea metabolic process (GO:0019627)3.32187575
94thyroid hormone metabolic process (GO:0042403)3.31787888
95epoxygenase P450 pathway (GO:0019373)3.30599087
96negative regulation of thymocyte apoptotic process (GO:0070244)3.29838825
97phenol-containing compound catabolic process (GO:0019336)3.28152353
98L-ascorbic acid metabolic process (GO:0019852)3.26601180
99urate metabolic process (GO:0046415)3.26130966
100fucose catabolic process (GO:0019317)3.26089610
101L-fucose metabolic process (GO:0042354)3.26089610
102L-fucose catabolic process (GO:0042355)3.26089610
103urea cycle (GO:0000050)3.25758351
104antibacterial humoral response (GO:0019731)3.20656204
105cellular response to nitric oxide (GO:0071732)3.18838732
106heme transport (GO:0015886)3.18396023
107pyrimidine ribonucleoside catabolic process (GO:0046133)3.18092566
108bicarbonate transport (GO:0015701)3.17683271
109positive regulation of icosanoid secretion (GO:0032305)3.17121025
110positive regulation of T cell differentiation in thymus (GO:0033089)3.15925825
111UDP-N-acetylglucosamine metabolic process (GO:0006047)3.15793773
112vitamin D metabolic process (GO:0042359)3.15617910
113high-density lipoprotein particle remodeling (GO:0034375)3.15465764
114mature B cell differentiation involved in immune response (GO:0002313)3.12896351
115regulation of systemic arterial blood pressure (GO:0003073)3.12895902
116positive regulation of glycoprotein metabolic process (GO:1903020)3.12884500
117positive regulation of cGMP metabolic process (GO:0030825)3.12375835
118diacylglycerol metabolic process (GO:0046339)3.11790410
119antimicrobial humoral response (GO:0019730)3.10351381
120alditol metabolic process (GO:0019400)3.09501240
121regulation of vitamin metabolic process (GO:0030656)3.08642597
122cholesterol homeostasis (GO:0042632)3.07975900
123phosphatidylserine acyl-chain remodeling (GO:0036150)3.07630843
124positive regulation of fatty acid transport (GO:2000193)3.07318735
125calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.07081332
126intestinal epithelial cell development (GO:0060576)3.06755992
127cGMP biosynthetic process (GO:0006182)3.06510125
128regulation of digestive system process (GO:0044058)3.05259367
129sterol homeostasis (GO:0055092)3.02998801
130regulation of germinal center formation (GO:0002634)3.02805661
131response to hydroperoxide (GO:0033194)3.02698650
132proline transport (GO:0015824)3.01900328
133nitrogen cycle metabolic process (GO:0071941)3.01617472
134sperm capacitation (GO:0048240)3.00476982
135regulation of penile erection (GO:0060405)3.00391822
136cellular carbohydrate catabolic process (GO:0044275)2.99813977
137thrombin receptor signaling pathway (GO:0070493)2.99148916
138glycosylceramide metabolic process (GO:0006677)2.93779846
139positive regulation of lipid catabolic process (GO:0050996)2.93716632
140reverse cholesterol transport (GO:0043691)2.93367860
141sulfation (GO:0051923)2.89186785
142dendritic cell migration (GO:0036336)2.87776044
143sphingoid metabolic process (GO:0046519)2.87706309
144dendritic cell chemotaxis (GO:0002407)2.87667066
145nucleobase catabolic process (GO:0046113)2.85594570
146diol metabolic process (GO:0034311)2.83510341
147negative regulation of cholesterol transport (GO:0032375)2.82268972
148negative regulation of sterol transport (GO:0032372)2.82268972
149purine nucleotide salvage (GO:0032261)2.81332237
150O-glycan processing (GO:0016266)2.78851755
151striated muscle atrophy (GO:0014891)2.77234586
152nucleoside transmembrane transport (GO:1901642)2.74742060
153intermediate filament organization (GO:0045109)2.74703398
154nucleoside transport (GO:0015858)2.74464952
155negative regulation of digestive system process (GO:0060457)2.73588425
156innate immune response in mucosa (GO:0002227)2.69946439
157regulation of actin nucleation (GO:0051125)2.69935951
158detection of bacterium (GO:0016045)2.69168673
159regulation of water loss via skin (GO:0033561)2.66003980
160histamine transport (GO:0051608)2.64138858
161angiotensin maturation (GO:0002003)13.1242308
162intestinal cholesterol absorption (GO:0030299)11.9085242
163intestinal absorption (GO:0050892)11.7567837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.92606883
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.69244280
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.82754761
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61952311
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.51818428
6VDR_22108803_ChIP-Seq_LS180_Human2.36945660
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34857795
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31685412
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.25443650
10GATA4_25053715_ChIP-Seq_YYC3_Human2.21549634
11SOX2_27498859_Chip-Seq_STOMACH_Mouse2.16377215
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10792058
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04249306
14PCGF2_27294783_Chip-Seq_NPCs_Mouse1.97902902
15SOX2_20726797_ChIP-Seq_SW620_Human1.95884365
16IRF8_22096565_ChIP-ChIP_GC-B_Human1.95515461
17LXR_22158963_ChIP-Seq_LIVER_Mouse1.87036830
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.85608052
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.81609045
20RXR_22158963_ChIP-Seq_LIVER_Mouse1.80176546
21TCF4_18268006_ChIP-ChIP_LS174T_Human1.77281912
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.76608432
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.72236492
24PPARA_22158963_ChIP-Seq_LIVER_Mouse1.69677938
25GATA1_22025678_ChIP-Seq_K562_Human1.65069129
26AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.64112192
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63364061
28GATA6_25053715_ChIP-Seq_YYC3_Human1.60827371
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.57731946
30ZNF274_21170338_ChIP-Seq_K562_Hela1.54306621
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54101641
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54066870
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53532885
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51683445
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48756122
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47193424
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.47045745
38* KLF5_25053715_ChIP-Seq_YYC3_Human1.46186495
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45944660
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45546433
41FOXA1_21572438_ChIP-Seq_LNCaP_Human1.41644123
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40997267
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39143154
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38509082
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36101591
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.36101591
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35600089
48TCF4_22108803_ChIP-Seq_LS180_Human1.34941617
49* NANOG_20526341_ChIP-Seq_ESCs_Human1.34262115
50PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.33291256
51RXR_22108803_ChIP-Seq_LS180_Human1.33210487
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.32740010
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30719407
54SMAD3_21741376_ChIP-Seq_HESCs_Human1.29938712
55NCOR_22424771_ChIP-Seq_293T_Human1.28760860
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.27250053
57AR_20517297_ChIP-Seq_VCAP_Human1.26496871
58CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.26192169
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.23779623
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21348544
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.21286474
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20065092
63FOXA1_25552417_ChIP-Seq_VCAP_Human1.20062226
64* P300_19829295_ChIP-Seq_ESCs_Human1.18815379
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18560121
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17876683
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17874306
68GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.17390299
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.15947124
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15393890
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14672411
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14235962
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13155413
74* TAF2_19829295_ChIP-Seq_ESCs_Human1.13038495
75HNF4A_19822575_ChIP-Seq_HepG2_Human1.11110717
76SOX2_19829295_ChIP-Seq_ESCs_Human1.10316226
77NANOG_19829295_ChIP-Seq_ESCs_Human1.10316226
78MYC_19829295_ChIP-Seq_ESCs_Human1.10307311
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.10270935
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10032415
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.09242955
82P53_22387025_ChIP-Seq_ESCs_Mouse1.08935493
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.08473515
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.07806749
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.06544085
86FUS_26573619_Chip-Seq_HEK293_Human1.06385092
87* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05048680
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04957900
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04807208
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03741384
91CEBPB_22108803_ChIP-Seq_LS180_Human1.03474176
92* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03215971
93P300_18555785_Chip-Seq_ESCs_Mouse1.03074586
94DROSHA_22980978_ChIP-Seq_HELA_Human1.03013151
95AHR_22903824_ChIP-Seq_MCF-7_Human1.02843718
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.02767594
97ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02327582
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.01860189
99ER_23166858_ChIP-Seq_MCF-7_Human1.01833217
100SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01422060
101FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00833301
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00829069
103HNFA_21074721_ChIP-Seq_CACO-2_Human1.00151477
104TP53_16413492_ChIP-PET_HCT116_Human1.00136985
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99882096
106IGF1R_20145208_ChIP-Seq_DFB_Human0.99823235
107ETV1_20927104_ChIP-Seq_GIST48_Human0.99594041
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99173194
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98397042
110P53_21459846_ChIP-Seq_SAOS-2_Human0.98343188
111RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98289169
112* TP53_18474530_ChIP-ChIP_U2OS_Human0.97811378
113RUNX1_27514584_Chip-Seq_MCF-7_Human0.97661232
114ZFX_18555785_Chip-Seq_ESCs_Mouse0.97249274
115STAT1_17558387_ChIP-Seq_HELA_Human0.97072958
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96802412
117CMYC_18555785_Chip-Seq_ESCs_Mouse0.96790650
118OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96515246
119GATA3_21878914_ChIP-Seq_MCF-7_Human0.96085022
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95416760
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95327429
122AR_25329375_ChIP-Seq_VCAP_Human0.95326406
123NANOG_18555785_Chip-Seq_ESCs_Mouse0.95062004
124OCT4_18555785_Chip-Seq_ESCs_Mouse0.94900569
125CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94776385
126KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94586664
127PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94472393
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93980685
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93777593
130CRX_20693478_ChIP-Seq_RETINA_Mouse0.93228307
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91064838
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90780373
133* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90646602
134CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90632189
135PHF8_20622853_ChIP-Seq_HELA_Human0.90145385
136SOX2_18555785_Chip-Seq_ESCs_Mouse0.89620532
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89410023
138E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89270465
139NMYC_18555785_Chip-Seq_ESCs_Mouse0.89207750
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89203297
141ERG_20517297_ChIP-Seq_VCAP_Human0.89169705
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88640719
143BCAT_22108803_ChIP-Seq_LS180_Human0.88562035
144GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88419992
145GATA2_19941826_ChIP-Seq_K562_Human0.88272807
146IRF8_21731497_ChIP-ChIP_J774_Mouse0.87688445
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86899744
148RBPJ_21746931_ChIP-Seq_IB4_Human0.86868888
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86860434
150CDX2_22108803_ChIP-Seq_LS180_Human0.86792931
151SMAD1_18555785_Chip-Seq_ESCs_Mouse0.86446524
152VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86410724
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85397127
154ESR2_21235772_ChIP-Seq_MCF-7_Human0.85122301
155ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84812114
156P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84696500
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.84471848
158* TP63_23658742_ChIP-Seq_EP156T_Human0.83764100
159* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83397145
160KLF4_18555785_Chip-Seq_ESCs_Mouse0.82529953
161CJUN_26792858_Chip-Seq_BT549_Human0.82303164
162IRF1_19129219_ChIP-ChIP_H3396_Human0.81974372
163ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81856967
164IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81696932
165EED_16625203_ChIP-ChIP_MESCs_Mouse0.81476842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.00662791
2MP0001666_abnormal_nutrient_absorption5.84435391
3MP0003183_abnormal_peptide_metabolism4.32782408
4MP0005365_abnormal_bile_salt3.98112636
5MP0004264_abnormal_extraembryonic_tissu3.37293647
6MP0010234_abnormal_vibrissa_follicle3.24343783
7MP0009840_abnormal_foam_cell3.00145562
8MP0000462_abnormal_digestive_system2.89566485
9MP0003866_abnormal_defecation2.82693118
10MP0003252_abnormal_bile_duct2.69723741
11MP0008875_abnormal_xenobiotic_pharmacok2.60912297
12MP0002796_impaired_skin_barrier2.57297495
13MP0005377_hearing/vestibular/ear_phenot2.43742473
14MP0003878_abnormal_ear_physiology2.43742473
15MP0003941_abnormal_skin_development2.34571023
16MP0005332_abnormal_amino_acid2.31950411
17MP0004019_abnormal_vitamin_homeostasis2.30104558
18MP0005084_abnormal_gallbladder_morpholo2.04510546
19MP0005085_abnormal_gallbladder_physiolo2.04063798
20MP0002254_reproductive_system_inflammat2.03975977
21MP0004147_increased_porphyrin_level1.99849561
22MP0002822_catalepsy1.96621814
23MP0000566_synostosis1.91528043
24MP0005451_abnormal_body_composition1.87484036
25MP0002138_abnormal_hepatobiliary_system1.86406936
26MP0001188_hyperpigmentation1.85427173
27MP0010329_abnormal_lipoprotein_level1.79123270
28MP0002098_abnormal_vibrissa_morphology1.78866642
29MP0009697_abnormal_copulation1.76573923
30MP0000538_abnormal_urinary_bladder1.69689787
31MP0010155_abnormal_intestine_physiology1.69089396
32MP0005501_abnormal_skin_physiology1.68590128
33MP0003195_calcinosis1.68585519
34MP0009379_abnormal_foot_pigmentation1.67476815
35MP0005381_digestive/alimentary_phenotyp1.63425757
36MP0004381_abnormal_hair_follicle1.59443264
37MP0002139_abnormal_hepatobiliary_system1.57885931
38MP0001873_stomach_inflammation1.57316730
39MP0001663_abnormal_digestive_system1.55358447
40MP0000490_abnormal_crypts_of1.53920951
41MP0003868_abnormal_feces_composition1.49466403
42MP0002277_abnormal_respiratory_mucosa1.48852845
43MP0001501_abnormal_sleep_pattern1.48629942
44MP0000467_abnormal_esophagus_morphology1.43353306
45MP0005367_renal/urinary_system_phenotyp1.40279059
46MP0000516_abnormal_urinary_system1.40279059
47MP0001485_abnormal_pinna_reflex1.38645595
48MP0005636_abnormal_mineral_homeostasis1.37498628
49MP0005670_abnormal_white_adipose1.36439370
50MP0003806_abnormal_nucleotide_metabolis1.35892194
51MP0000477_abnormal_intestine_morphology1.34423527
52MP0010678_abnormal_skin_adnexa1.33727406
53MP0005448_abnormal_energy_balance1.33413020
54MP0003718_maternal_effect1.32518740
55MP0005409_darkened_coat_color1.31192624
56MP0004947_skin_inflammation1.28613983
57MP0000537_abnormal_urethra_morphology1.26639045
58MP0002118_abnormal_lipid_homeostasis1.26438330
59MP0000579_abnormal_nail_morphology1.26402814
60* MP0001664_abnormal_digestion1.25631186
61MP0005174_abnormal_tail_pigmentation1.20411044
62MP0003191_abnormal_cellular_cholesterol1.14233849
63MP0001756_abnormal_urination1.12946027
64MP0000230_abnormal_systemic_arterial1.12491856
65MP0001216_abnormal_epidermal_layer1.12162343
66MP0000383_abnormal_hair_follicle1.09739070
67MP0002148_abnormal_hypersensitivity_rea1.09541877
68MP0004043_abnormal_pH_regulation1.06812957
69MP0002876_abnormal_thyroid_physiology1.03932876
70MP0005535_abnormal_body_temperature1.00215033
71MP0005166_decreased_susceptibility_to0.97881127
72MP0000678_abnormal_parathyroid_gland0.96929003
73MP0003315_abnormal_perineum_morphology0.95654705
74MP0003938_abnormal_ear_development0.93012310
75MP0003453_abnormal_keratinocyte_physiol0.92800499
76MP0003950_abnormal_plasma_membrane0.91848730
77MP0010352_gastrointestinal_tract_polyps0.91726600
78MP0004270_analgesia0.91486144
79MP0004782_abnormal_surfactant_physiolog0.88793936
80MP0002089_abnormal_postnatal_growth/wei0.87026144
81MP0000470_abnormal_stomach_morphology0.86007001
82MP0003136_yellow_coat_color0.85226016
83MP0003638_abnormal_response/metabolism_0.84660093
84MP0000609_abnormal_liver_physiology0.84644854
85MP0002132_abnormal_respiratory_system0.84521992
86MP0000613_abnormal_salivary_gland0.84063715
87MP0001191_abnormal_skin_condition0.83604684
88MP0000427_abnormal_hair_cycle0.82615521
89MP0002009_preneoplasia0.82188112
90MP0009764_decreased_sensitivity_to0.80835653
91MP0002971_abnormal_brown_adipose0.76148588
92MP0000377_abnormal_hair_follicle0.75528813
93MP0010771_integument_phenotype0.74327053
94MP0009765_abnormal_xenobiotic_induced0.72873985
95MP0002060_abnormal_skin_morphology0.72770093
96MP0001986_abnormal_taste_sensitivity0.72405958
97MP0008872_abnormal_physiological_respon0.72196669
98MP0001764_abnormal_homeostasis0.71886718
99MP0009642_abnormal_blood_homeostasis0.71321862
100MP0003300_gastrointestinal_ulcer0.71246640
101MP0005584_abnormal_enzyme/coenzyme_acti0.71065212
102MP0005319_abnormal_enzyme/_coenzyme0.70651598
103MP0005645_abnormal_hypothalamus_physiol0.70019975
104MP0005310_abnormal_salivary_gland0.69478750
105MP0010386_abnormal_urinary_bladder0.69219684
106MP0003953_abnormal_hormone_level0.64731294
107MP0001845_abnormal_inflammatory_respons0.64504779
108MP0000015_abnormal_ear_pigmentation0.64403793
109MP0000762_abnormal_tongue_morphology0.63820362
110MP0002102_abnormal_ear_morphology0.63114500
111MP0009053_abnormal_anal_canal0.62713007
112MP0009785_altered_susceptibility_to0.61799957
113MP0009115_abnormal_fat_cell0.60753871
114MP0005551_abnormal_eye_electrophysiolog0.60340321
115MP0004742_abnormal_vestibular_system0.59279456
116MP0002078_abnormal_glucose_homeostasis0.57987844
117MP0004885_abnormal_endolymph0.57850796
118MP0003385_abnormal_body_wall0.57028662
119MP0008469_abnormal_protein_level0.55555087
120MP0003724_increased_susceptibility_to0.55166952
121MP0009643_abnormal_urine_homeostasis0.53421302
122MP0001346_abnormal_lacrimal_gland0.53219436
123MP0001765_abnormal_ion_homeostasis0.52833990
124MP0002069_abnormal_eating/drinking_beha0.51974745
125MP0003011_delayed_dark_adaptation0.51424844
126MP0003879_abnormal_hair_cell0.50202039
127MP0005395_other_phenotype0.49779916
128MP0003283_abnormal_digestive_organ0.49281415
129MP0002249_abnormal_larynx_morphology0.48885303
130MP0005167_abnormal_blood-brain_barrier0.48640231
131MP0005334_abnormal_fat_pad0.47438198
132MP0000026_abnormal_inner_ear0.46334645
133MP0005025_abnormal_response_to0.46216119
134MP0002136_abnormal_kidney_physiology0.45775349
135MP0002638_abnormal_pupillary_reflex0.45714468
136MP0008775_abnormal_heart_ventricle0.45060521
137MP0002938_white_spotting0.43496123
138MP0004215_abnormal_myocardial_fiber0.42668997
139MP0006082_CNS_inflammation0.42627041
140MP0005464_abnormal_platelet_physiology0.42161177
141MP0005671_abnormal_response_to0.40679474
142MP0002733_abnormal_thermal_nociception0.40037791
143MP0002135_abnormal_kidney_morphology0.39534456
144MP0004484_altered_response_of0.39238374

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)6.60906838
2Acanthocytosis (HP:0001927)5.84728382
3Abnormality of glutamine family amino acid metabolism (HP:0010902)5.68435144
4Conjugated hyperbilirubinemia (HP:0002908)5.23875846
5Abnormality of proline metabolism (HP:0010907)5.20226336
6Hydroxyprolinuria (HP:0003080)5.20226336
7Autoimmune thrombocytopenia (HP:0001973)5.15854389
8Hypobetalipoproteinemia (HP:0003563)5.07499830
9Increased IgE level (HP:0003212)4.70561497
10Malnutrition (HP:0004395)4.60402414
11Chronic diarrhea (HP:0002028)4.55548954
12Widely patent fontanelles and sutures (HP:0004492)4.52673202
13Autoimmune hemolytic anemia (HP:0001890)4.51576465
14Right ventricular cardiomyopathy (HP:0011663)4.40852347
15Abnormality of serine family amino acid metabolism (HP:0010894)3.98145739
16Abnormality of glycine metabolism (HP:0010895)3.98145739
17Pigmentary retinal degeneration (HP:0001146)3.93608363
18Decreased circulating renin level (HP:0003351)3.64791708
19Proximal tubulopathy (HP:0000114)3.48423641
20Dehydration (HP:0001944)3.45066765
21Cupped ribs (HP:0000887)3.44343814
22Nausea (HP:0002018)3.29928807
23Severe combined immunodeficiency (HP:0004430)3.25480803
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.23663574
25Metabolic alkalosis (HP:0200114)3.22471377
26Poikilocytosis (HP:0004447)3.22078491
27Facial shape deformation (HP:0011334)3.20152452
28Potter facies (HP:0002009)3.20152452
29Congenital sensorineural hearing impairment (HP:0008527)3.17934096
30Posterior subcapsular cataract (HP:0007787)3.12519267
31Alkalosis (HP:0001948)3.12233136
32Fat malabsorption (HP:0002630)3.06021615
33Abnormality of B cell number (HP:0010975)3.01384545
34B lymphocytopenia (HP:0010976)3.01384545
35Megaloblastic anemia (HP:0001889)2.94584401
36Cheilitis (HP:0100825)2.89024850
37Thyroiditis (HP:0100646)2.87888969
38Villous atrophy (HP:0011473)2.82269165
39Abnormality of small intestinal villus morphology (HP:0011472)2.82269165
40Hyperuricemia (HP:0002149)2.80503487
41Increased purine levels (HP:0004368)2.80503487
42Xanthomatosis (HP:0000991)2.79862160
43Combined immunodeficiency (HP:0005387)2.79481422
44Steatorrhea (HP:0002570)2.76021363
45Systemic lupus erythematosus (HP:0002725)2.73545581
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73202533
47Abnormality of renin-angiotensin system (HP:0000847)2.72824756
48Woolly hair (HP:0002224)2.71251456
49Hypolipoproteinemia (HP:0010981)2.68796713
50Hyperphosphaturia (HP:0003109)2.68283807
51Milia (HP:0001056)2.66367589
52Abdominal distention (HP:0003270)2.65254311
53Abnormality of the vitamin B12 metabolism (HP:0004341)2.62662188
54Aplasia cutis congenita (HP:0001057)2.62439550
55Abnormal urine phosphate concentration (HP:0012599)2.61043105
56Abnormal glucose tolerance (HP:0001952)2.59863979
57Hyperglycinuria (HP:0003108)2.58526445
58Metabolic acidosis (HP:0001942)2.55748657
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.53009000
60Osteomalacia (HP:0002749)2.52805909
61Hypoproteinemia (HP:0003075)2.52624081
62Hyperammonemia (HP:0001987)2.50262209
63Prostate neoplasm (HP:0100787)2.49031811
64Abnormality of purine metabolism (HP:0004352)2.48750519
65Abnormality of urine glucose concentration (HP:0011016)2.47725876
66Glycosuria (HP:0003076)2.47725876
67Enlarged epiphyses (HP:0010580)2.47668000
68Mesangial abnormality (HP:0001966)2.46136787
69Chorioretinal atrophy (HP:0000533)2.44048102
70Gingivitis (HP:0000230)2.42290775
71Pustule (HP:0200039)2.41827882
72Lip pit (HP:0100267)2.40082254
73Abnormality of vitamin B metabolism (HP:0004340)2.38826953
74Abnormality of eosinophils (HP:0001879)2.37662058
75Wide cranial sutures (HP:0010537)2.36910732
76Hyperactive renin-angiotensin system (HP:0000841)2.36562693
77Abnormality of the gastric mucosa (HP:0004295)2.34989021
78Plantar hyperkeratosis (HP:0007556)2.34173535
79Progressive sensorineural hearing impairment (HP:0000408)2.30841028
80Abnormality of sulfur amino acid metabolism (HP:0004339)2.30820556
81Abnormality of nucleobase metabolism (HP:0010932)2.27987820
82Abnormal albumin level (HP:0012116)2.26046276
83Chromsome breakage (HP:0040012)2.24823742
84White forelock (HP:0002211)2.22676796
85Lethargy (HP:0001254)2.21245197
86Congenital ichthyosiform erythroderma (HP:0007431)2.20780588
87Hyperventilation (HP:0002883)2.18855817
88Eosinophilia (HP:0001880)2.18253404
89Encephalitis (HP:0002383)2.15905367
90Dicarboxylic aciduria (HP:0003215)2.14961639
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14961639
92Cerebral palsy (HP:0100021)2.14713249
93Delayed epiphyseal ossification (HP:0002663)2.13353473
94Abnormality of magnesium homeostasis (HP:0004921)2.12344936
95Alopecia of scalp (HP:0002293)2.11872848
96Methylmalonic aciduria (HP:0012120)2.10944729
97Abnormal platelet volume (HP:0011876)2.08611346
98Thin bony cortex (HP:0002753)2.08509265
99Onycholysis (HP:0001806)2.07678362
100Amelogenesis imperfecta (HP:0000705)2.07507859
101Hypothermia (HP:0002045)2.07366337
102Gastrointestinal dysmotility (HP:0002579)2.05803239
103Parakeratosis (HP:0001036)2.05798103
104Fragile nails (HP:0001808)2.05340020
105Epidermoid cyst (HP:0200040)2.04591713
106Pancreatitis (HP:0001733)2.01213802
107Gout (HP:0001997)2.00828474
108Nephrolithiasis (HP:0000787)2.00577643
109Pruritus (HP:0000989)1.99930782
110Abnormality of the costochondral junction (HP:0000919)1.99886519
111Increased mean platelet volume (HP:0011877)1.99556141
112Curly hair (HP:0002212)1.99455280
113Focal segmental glomerulosclerosis (HP:0000097)1.98011080
114Abnormality of secondary sexual hair (HP:0009888)1.94025939
115Abnormality of the axillary hair (HP:0100134)1.94025939
116Progressive hearing impairment (HP:0001730)1.93156615
117Reduced antithrombin III activity (HP:0001976)1.91195586
118Patchy hypopigmentation of hair (HP:0011365)1.90786988
119Renal tubular dysfunction (HP:0000124)1.88833277
120Pili torti (HP:0003777)1.88578960
121Granulocytopenia (HP:0001913)1.87724946
122Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87563540
123Hyperparathyroidism (HP:0000843)1.87240648
124Renal tubular acidosis (HP:0001947)1.86374749
125Aplasia of the musculature (HP:0100854)1.84339840
126Abnormal biliary tract morphology (HP:0012440)1.83809472
127Abnormality of pyrimidine metabolism (HP:0004353)1.82687386
128Abnormality of vitamin metabolism (HP:0100508)1.82135115
129Recurrent fungal infections (HP:0002841)1.80375960
130Irritability (HP:0000737)1.79854994
131Abnormality of chloride homeostasis (HP:0011422)1.79475694
132Stomach cancer (HP:0012126)1.79317365
133Abnormality of the renal cortex (HP:0011035)1.79208845
134Petechiae (HP:0000967)1.79147107
135Hypoplasia of dental enamel (HP:0006297)1.78583615
136Hypokalemia (HP:0002900)1.76664343
137Delayed CNS myelination (HP:0002188)1.75531857
138Confusion (HP:0001289)1.75209872
139Palmoplantar hyperkeratosis (HP:0000972)1.74850303
140Anal stenosis (HP:0002025)1.74612389
141Symptomatic seizures (HP:0011145)1.74056632
142Duplicated collecting system (HP:0000081)1.73053999
143Abnormality of renal excretion (HP:0011036)1.72827895
144Palmar hyperkeratosis (HP:0010765)1.71535077
145Hypophosphatemic rickets (HP:0004912)1.70766664
146Urethral obstruction (HP:0000796)1.69935462
147Subcapsular cataract (HP:0000523)1.69610473
148Hyperphosphatemia (HP:0002905)1.68785514
149Generalized aminoaciduria (HP:0002909)1.68257525
150Abnormality of serum amino acid levels (HP:0003112)1.67061706
151Abnormal urine output (HP:0012590)1.65470685
152Mildly elevated creatine phosphokinase (HP:0008180)1.64808288
153Renal cortical cysts (HP:0000803)1.64532255
154Cone-rod dystrophy (HP:0000548)1.64428488
155Premature loss of primary teeth (HP:0006323)1.63926896
156Recurrent viral infections (HP:0004429)1.63859941
157Hypophosphatemia (HP:0002148)1.63550581
158Hypoalbuminemia (HP:0003073)1.63314952
159Hypotension (HP:0002615)1.62375719
160Enlarged kidneys (HP:0000105)1.60398550
161Congenital stationary night blindness (HP:0007642)1.59565221
162Pancreatic cysts (HP:0001737)1.58093551
163Metaphyseal irregularity (HP:0003025)1.58028338
164Abolished electroretinogram (ERG) (HP:0000550)1.57617243

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.02870659
2MST46.44713832
3FRK4.73539005
4AKT34.20349639
5MST1R3.56387014
6EPHA23.03591962
7GRK62.83944198
8STK392.82327822
9IRAK32.69301408
10OXSR12.67229181
11NME12.58401640
12PRKG22.53566963
13LMTK22.51247573
14NUAK12.51147335
15CASK2.19990104
16TNIK2.19773605
17ERN11.94546973
18MAP3K141.88340620
19GRK11.86497305
20EPHB21.85414679
21BLK1.60082173
22MAP2K21.56882766
23IRAK41.53291555
24WNK41.53150795
25PINK11.50724891
26STK101.47938949
27PDK21.30040133
28DAPK21.28527571
29NLK1.26177947
30EPHA41.25478365
31TTK1.23305916
32ZAK1.21438087
33TLK11.20928744
34YES11.18854876
35WNK31.18086377
36PRKCI1.13214862
37TXK1.05996634
38PBK1.01089893
39MAP4K21.00775089
40LATS10.96604921
41EIF2AK20.96428953
42MATK0.95600604
43BMPR1B0.92837407
44RIPK40.91788415
45RIPK10.90158729
46MAP2K60.88932522
47FER0.87181074
48CDK120.85529513
49PIM20.84735720
50IKBKE0.81869244
51TAOK30.80270770
52PRKAA20.80150368
53PRKCZ0.79482510
54STK160.78196796
55MAP3K70.77958771
56SIK30.77301124
57PIK3CA0.76923262
58MAPKAPK30.76843495
59ADRBK20.76044300
60ADRBK10.75285541
61MAP3K100.75142536
62PTK60.74642825
63MAP3K20.74571375
64PRKACG0.71115742
65MAPK150.70254986
66MAPK130.70038201
67NEK60.65875930
68STK240.59393187
69INSRR0.56913165
70CDK30.56779072
71CSK0.56669462
72BMX0.56407836
73MET0.54802723
74CHUK0.54750044
75ERBB20.53827031
76BCR0.52345680
77TESK20.51800092
78TRPM70.51488301
79MAP3K40.50847844
80PRKACA0.50296805
81IKBKB0.50124233
82BMPR20.49996353
83MYLK0.49879928
84IRAK10.49666629
85DDR20.49628144
86EPHB10.48546756
87PRKCG0.46460265
88CAMK2A0.46095886
89GRK70.45413894
90MAPKAPK20.43842991
91MAPKAPK50.43102511
92FGFR20.42501542
93CAMK2D0.42333162
94PRKCE0.42330733
95KIT0.42184593
96IGF1R0.41461693
97STK110.40513495
98PRKCQ0.40427437
99FGR0.40358382
100CLK10.40284748
101TGFBR10.40001632
102PAK30.39504268
103EPHA30.38571897
104PIK3CG0.38148158
105CDK70.38122004
106MKNK20.37531792
107TBK10.36118580
108SYK0.35864291
109STK30.34209256
110PRKCA0.33893039
111PRKD20.33528097
112TNK20.33208742
113BRD40.32947357
114CDK190.32808414
115PRKCD0.32658969
116PRKG10.32073460
117STK38L0.31504548
118FGFR30.30463165
119MAPK110.28521115
120PDPK10.28446447
121SRC0.28338370
122TESK10.28171641
123MAP4K10.27727254
124PIM10.27673149
125MAP3K120.27159453
126TEC0.26530200
127STK40.25954153
128CDK90.25243092
129JAK30.25185118
130GRK50.24228636
131CSNK1A10.24016509
132PTK20.23936579
133ABL20.23395221
134TYK20.22684859
135MAP3K110.22267566
136CHEK20.21783143
137MAP3K80.21574008
138ERBB30.21471287
139DMPK0.21469057
140AURKB0.21407220
141TRIM280.20925679
142ITK0.20174151

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.81243513
2Renin-angiotensin system_Homo sapiens_hsa046145.54864998
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.83416126
4Vitamin digestion and absorption_Homo sapiens_hsa049774.62015891
5Mineral absorption_Homo sapiens_hsa049784.40728065
6Caffeine metabolism_Homo sapiens_hsa002323.07294203
7Galactose metabolism_Homo sapiens_hsa000523.00371797
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.77750273
9Starch and sucrose metabolism_Homo sapiens_hsa005002.69799612
10Sphingolipid metabolism_Homo sapiens_hsa006002.49502675
11* Protein digestion and absorption_Homo sapiens_hsa049742.18425071
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02831353
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.02011555
14Folate biosynthesis_Homo sapiens_hsa007901.99260111
15Arginine biosynthesis_Homo sapiens_hsa002201.85755771
16Histidine metabolism_Homo sapiens_hsa003401.82420897
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66126270
18Sulfur metabolism_Homo sapiens_hsa009201.51729574
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47315466
20Bile secretion_Homo sapiens_hsa049761.38887613
21Fructose and mannose metabolism_Homo sapiens_hsa000511.29417901
22Fatty acid degradation_Homo sapiens_hsa000711.28421358
23Glutathione metabolism_Homo sapiens_hsa004801.23876785
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22023550
25Arachidonic acid metabolism_Homo sapiens_hsa005901.17126467
26ABC transporters_Homo sapiens_hsa020101.13358838
27Asthma_Homo sapiens_hsa053101.11700184
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10881376
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.10152880
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.08849087
31Primary bile acid biosynthesis_Homo sapiens_hsa001200.96894334
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95269773
33Hematopoietic cell lineage_Homo sapiens_hsa046400.94100535
34Glycerolipid metabolism_Homo sapiens_hsa005610.93279496
35Phenylalanine metabolism_Homo sapiens_hsa003600.93037226
36Butanoate metabolism_Homo sapiens_hsa006500.91957637
37Peroxisome_Homo sapiens_hsa041460.89986397
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87384592
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87317360
40PPAR signaling pathway_Homo sapiens_hsa033200.86224694
41Tryptophan metabolism_Homo sapiens_hsa003800.82400053
42Retinol metabolism_Homo sapiens_hsa008300.78160079
43Linoleic acid metabolism_Homo sapiens_hsa005910.75044830
44Primary immunodeficiency_Homo sapiens_hsa053400.74769184
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74570162
46Arginine and proline metabolism_Homo sapiens_hsa003300.72328203
47Ether lipid metabolism_Homo sapiens_hsa005650.71934553
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66689988
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.63724475
50Tyrosine metabolism_Homo sapiens_hsa003500.63373856
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.62188923
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61495381
53African trypanosomiasis_Homo sapiens_hsa051430.61411368
54Type I diabetes mellitus_Homo sapiens_hsa049400.57907852
55Fatty acid metabolism_Homo sapiens_hsa012120.55092572
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53993079
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53012972
58Staphylococcus aureus infection_Homo sapiens_hsa051500.52263157
59Nitrogen metabolism_Homo sapiens_hsa009100.50205003
60Tight junction_Homo sapiens_hsa045300.47522149
61Sulfur relay system_Homo sapiens_hsa041220.46045639
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46039609
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45374591
64beta-Alanine metabolism_Homo sapiens_hsa004100.45280054
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44798737
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44543495
67Fatty acid biosynthesis_Homo sapiens_hsa000610.42552018
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42174761
69Chemical carcinogenesis_Homo sapiens_hsa052040.41830229
70Propanoate metabolism_Homo sapiens_hsa006400.40677396
71Salmonella infection_Homo sapiens_hsa051320.40439211
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40167484
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.39963459
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39196028
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38876607
76Serotonergic synapse_Homo sapiens_hsa047260.38314725
77Insulin secretion_Homo sapiens_hsa049110.38258595
78Graft-versus-host disease_Homo sapiens_hsa053320.37978788
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.37697920
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37466038
81Hepatitis C_Homo sapiens_hsa051600.37281497
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37130359
83Pancreatic secretion_Homo sapiens_hsa049720.34917976
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34611513
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33660314
86Adherens junction_Homo sapiens_hsa045200.31971183
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30155835
88Steroid biosynthesis_Homo sapiens_hsa001000.29340421
89Inositol phosphate metabolism_Homo sapiens_hsa005620.29254540
90Type II diabetes mellitus_Homo sapiens_hsa049300.27764794
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.26412530
92Cocaine addiction_Homo sapiens_hsa050300.25932483
93Fatty acid elongation_Homo sapiens_hsa000620.25697611
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24809185
95Ovarian steroidogenesis_Homo sapiens_hsa049130.24698740
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24026356
97Selenocompound metabolism_Homo sapiens_hsa004500.23579066
98Influenza A_Homo sapiens_hsa051640.22669555
99Insulin resistance_Homo sapiens_hsa049310.22106313
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21997301
101Metabolic pathways_Homo sapiens_hsa011000.21323204
102Thyroid hormone synthesis_Homo sapiens_hsa049180.20581992
103Renin secretion_Homo sapiens_hsa049240.19634143
104Antigen processing and presentation_Homo sapiens_hsa046120.19190902
105Allograft rejection_Homo sapiens_hsa053300.18290561
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18239581
107Other glycan degradation_Homo sapiens_hsa005110.18107265
108Purine metabolism_Homo sapiens_hsa002300.17812649
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.17347872
110TNF signaling pathway_Homo sapiens_hsa046680.17314711
111Pertussis_Homo sapiens_hsa051330.16635350
112Autoimmune thyroid disease_Homo sapiens_hsa053200.16415786
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16005897
114Amphetamine addiction_Homo sapiens_hsa050310.14944118
115Salivary secretion_Homo sapiens_hsa049700.14815621
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14777084
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.14029426
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.13373795
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13031727
120Gastric acid secretion_Homo sapiens_hsa049710.12594415
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.11549786
122Complement and coagulation cascades_Homo sapiens_hsa046100.10831908
123Apoptosis_Homo sapiens_hsa042100.10373107
124Phototransduction_Homo sapiens_hsa047440.10220814
125Glucagon signaling pathway_Homo sapiens_hsa049220.09364290
126Pyruvate metabolism_Homo sapiens_hsa006200.08919774
127Tuberculosis_Homo sapiens_hsa051520.08597092
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.07392780
129Leishmaniasis_Homo sapiens_hsa051400.06602972
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.06176544
131Measles_Homo sapiens_hsa051620.06048796
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.05670856
133Legionellosis_Homo sapiens_hsa051340.04760296
134Oxidative phosphorylation_Homo sapiens_hsa001900.04633310
135Long-term depression_Homo sapiens_hsa047300.04619297
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.04283379
137Taste transduction_Homo sapiens_hsa047420.03757536
138Herpes simplex infection_Homo sapiens_hsa051680.03635675
139Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.02953088
140Nicotine addiction_Homo sapiens_hsa050330.02850747

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