SLC14A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.16060073
2ribosomal small subunit assembly (GO:0000028)5.71975250
3definitive hemopoiesis (GO:0060216)5.46483848
4protoporphyrinogen IX metabolic process (GO:0046501)4.66883648
5protoporphyrinogen IX biosynthetic process (GO:0006782)4.63412533
6DNA deamination (GO:0045006)4.59994316
7telomere maintenance via semi-conservative replication (GO:0032201)4.55625564
8DNA strand elongation involved in DNA replication (GO:0006271)4.48941660
9DNA strand elongation (GO:0022616)4.47242853
10heme biosynthetic process (GO:0006783)4.46078311
11oxygen transport (GO:0015671)4.37959198
12megakaryocyte development (GO:0035855)4.29872003
13embryonic hemopoiesis (GO:0035162)4.29384143
14daunorubicin metabolic process (GO:0044597)4.25611745
15polyketide metabolic process (GO:0030638)4.25611745
16doxorubicin metabolic process (GO:0044598)4.25611745
17positive regulation of B cell differentiation (GO:0045579)4.22844663
18erythrocyte maturation (GO:0043249)4.21164947
19axon ensheathment in central nervous system (GO:0032291)4.17018741
20central nervous system myelination (GO:0022010)4.17018741
21DNA unwinding involved in DNA replication (GO:0006268)4.12656929
22regulation of erythrocyte differentiation (GO:0045646)4.09269944
23positive regulation of granulocyte differentiation (GO:0030854)4.07813894
24CENP-A containing nucleosome assembly (GO:0034080)4.03363851
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.03182564
26DNA replication initiation (GO:0006270)4.00443680
27blood coagulation, intrinsic pathway (GO:0007597)3.99375564
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99094770
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.99094770
30viral transcription (GO:0019083)3.98764871
31telomere maintenance via recombination (GO:0000722)3.96238387
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.94086999
33porphyrin-containing compound biosynthetic process (GO:0006779)3.89231058
34translational termination (GO:0006415)3.81105827
35erythrocyte development (GO:0048821)3.76358414
36kinetochore organization (GO:0051383)3.68551835
37negative regulation of cytosolic calcium ion concentration (GO:0051481)3.68427234
38hemoglobin metabolic process (GO:0020027)3.67983583
39mitotic recombination (GO:0006312)3.67444443
40platelet dense granule organization (GO:0060155)3.65853237
41chromatin remodeling at centromere (GO:0031055)3.63273201
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.59420072
43translational elongation (GO:0006414)3.58897699
44synaptic vesicle docking involved in exocytosis (GO:0016081)3.57923284
45tetrapyrrole biosynthetic process (GO:0033014)3.51964539
46regulation of neurotransmitter uptake (GO:0051580)3.50139539
47kinetochore assembly (GO:0051382)3.49646039
48positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.46494441
49heme metabolic process (GO:0042168)3.45820421
50response to gravity (GO:0009629)3.44561426
51telomere maintenance via telomere lengthening (GO:0010833)3.42885929
52L-amino acid import (GO:0043092)3.41535237
53myeloid cell development (GO:0061515)3.38154957
54DNA replication-independent nucleosome assembly (GO:0006336)3.37574345
55DNA replication-independent nucleosome organization (GO:0034724)3.37574345
56response to methylmercury (GO:0051597)3.35458082
57potassium ion import (GO:0010107)3.35082686
58antigen processing and presentation of endogenous antigen (GO:0019883)3.34018372
59* one-carbon compound transport (GO:0019755)3.33808105
60positive regulation of gamma-delta T cell activation (GO:0046645)3.33702387
61histamine transport (GO:0051608)3.32782341
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31406944
63positive regulation of erythrocyte differentiation (GO:0045648)3.30900200
64protein localization to kinetochore (GO:0034501)3.30014302
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.28658010
66protein localization to chromosome, centromeric region (GO:0071459)3.26836683
67neurotransmitter uptake (GO:0001504)3.25986081
68maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.25412648
69cotranslational protein targeting to membrane (GO:0006613)3.24901387
70gamma-aminobutyric acid transport (GO:0015812)3.24685471
71import into cell (GO:0098657)3.19633496
72protein targeting to ER (GO:0045047)3.16841457
73regulation of protein glycosylation (GO:0060049)3.15276344
74secretory granule organization (GO:0033363)3.14137563
75replication fork processing (GO:0031297)3.11526935
76cellular potassium ion homeostasis (GO:0030007)3.11245600
77positive regulation of fibroblast migration (GO:0010763)3.06220742
78astrocyte differentiation (GO:0048708)3.05101414
79ribosomal small subunit biogenesis (GO:0042274)3.05069309
80relaxation of cardiac muscle (GO:0055119)3.04670807
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02589198
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.02560339
83positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.02408399
84erythrocyte differentiation (GO:0030218)3.01701376
85protein localization to endoplasmic reticulum (GO:0070972)3.01139025
86mast cell activation (GO:0045576)3.00814045
87establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99856207
88response to interferon-beta (GO:0035456)2.98797631
89antigen processing and presentation via MHC class Ib (GO:0002475)2.98188836
90pseudouridine synthesis (GO:0001522)2.97982477
91regulation of DNA endoreduplication (GO:0032875)2.97751881
92gas transport (GO:0015669)2.96151400
93porphyrin-containing compound metabolic process (GO:0006778)2.95468085
94modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.95370027
95positive regulation by organism of defense response of other organism involved in symbiotic interact2.95370027
96modulation by symbiont of host immune response (GO:0052553)2.95370027
97positive regulation by symbiont of host defense response (GO:0052509)2.95370027
98modulation by symbiont of host defense response (GO:0052031)2.95370027
99modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.95370027
100glutamate secretion (GO:0014047)2.95280132
101maturation of SSU-rRNA (GO:0030490)2.93947710
102attachment of spindle microtubules to kinetochore (GO:0008608)2.92726933
103positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92358344
104telomere maintenance (GO:0000723)2.92334508
105IMP biosynthetic process (GO:0006188)2.92212235
106relaxation of smooth muscle (GO:0044557)2.92119804
107metallo-sulfur cluster assembly (GO:0031163)2.92066638
108iron-sulfur cluster assembly (GO:0016226)2.92066638
109positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.91163191
110synaptic vesicle maturation (GO:0016188)2.90977790
111DNA replication checkpoint (GO:0000076)2.90690387
112regulation of inositol phosphate biosynthetic process (GO:0010919)2.90571875
113telomere organization (GO:0032200)2.90538891
114retinal cone cell development (GO:0046549)2.88113805
115DNA topological change (GO:0006265)2.87654299
116cellular protein complex disassembly (GO:0043624)2.87609982
117protein K11-linked deubiquitination (GO:0035871)2.87278486
118T cell homeostasis (GO:0043029)2.86543891
119histone exchange (GO:0043486)2.85234973
120gamma-aminobutyric acid signaling pathway (GO:0007214)2.84398204
121long-term synaptic potentiation (GO:0060291)2.84228991
122viral life cycle (GO:0019058)2.83989756
123negative regulation of cell aging (GO:0090344)2.83776015
124neuronal action potential propagation (GO:0019227)2.83165696
125interferon-gamma production (GO:0032609)2.83023945
126regulation of histone H3-K9 methylation (GO:0051570)2.82858207
127positive regulation of macrophage differentiation (GO:0045651)2.82009987
128cyclic nucleotide catabolic process (GO:0009214)2.80792971
129potassium ion homeostasis (GO:0055075)2.79169706
130negative regulation of erythrocyte differentiation (GO:0045647)2.78878363
131regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.76815645
132negative regulation of cAMP-mediated signaling (GO:0043951)2.74417130
133granulocyte differentiation (GO:0030851)2.73815253
134macroautophagy (GO:0016236)2.73607873
135mitotic sister chromatid cohesion (GO:0007064)2.73562265
136regulation of spindle organization (GO:0090224)2.73437955
137translational initiation (GO:0006413)2.73169652
138regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.72055065
139negative regulation of neurotransmitter transport (GO:0051589)2.71345703
140postsynaptic membrane organization (GO:0001941)2.70391956
141establishment of chromosome localization (GO:0051303)2.70218246
142proline transport (GO:0015824)2.70046056
143membrane depolarization during action potential (GO:0086010)2.65282852
144relaxation of muscle (GO:0090075)2.65141421
145amino acid import (GO:0043090)2.61197579
146response to nitrosative stress (GO:0051409)2.60638461
147synaptic transmission, glutamatergic (GO:0035249)2.60031698
148presynaptic membrane assembly (GO:0097105)2.59317193
149regulation of female receptivity (GO:0045924)2.57149995
150L-fucose catabolic process (GO:0042355)2.56017310
151fucose catabolic process (GO:0019317)2.56017310
152L-fucose metabolic process (GO:0042354)2.56017310
153startle response (GO:0001964)2.54863564
154glycine transport (GO:0015816)2.51091091
155negative regulation of mast cell activation (GO:0033004)2.49418451
156locomotory exploration behavior (GO:0035641)2.47081163
157neuron-neuron synaptic transmission (GO:0007270)2.42609753
158dopamine transport (GO:0015872)2.41842538
159ionotropic glutamate receptor signaling pathway (GO:0035235)2.41620530
160positive regulation of meiosis (GO:0045836)2.41486383
161negative regulation of execution phase of apoptosis (GO:1900118)2.39961570
162synaptic vesicle exocytosis (GO:0016079)2.39811329
163presynaptic membrane organization (GO:0097090)2.39198324
164response to lead ion (GO:0010288)2.38475224
165regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.37162576
166regulation of cell communication by electrical coupling (GO:0010649)2.36762902
167regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.34749420
168adaptation of signaling pathway (GO:0023058)2.31540903
169positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.30351898
170regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.29878880
171regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.29878880
172xenobiotic catabolic process (GO:0042178)2.29615929
173positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.28018789
174cAMP catabolic process (GO:0006198)2.27419132
175neurotransmitter secretion (GO:0007269)2.26995964
176regulation of platelet aggregation (GO:0090330)2.26484093
177regulation of neurotransmitter transport (GO:0051588)2.25300563
178glutamate receptor signaling pathway (GO:0007215)2.24129512
179detection of calcium ion (GO:0005513)2.23515636
180regulation of voltage-gated calcium channel activity (GO:1901385)2.22814361
181regulation of short-term neuronal synaptic plasticity (GO:0048172)2.21901664
182negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.18975631
183astrocyte development (GO:0014002)2.18262099
184regulation of fibroblast migration (GO:0010762)2.18056829
185regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.17477872
186positive regulation of neurological system process (GO:0031646)2.16882115
187positive regulation of meiotic cell cycle (GO:0051446)2.16842080
188regulation of synaptic vesicle transport (GO:1902803)2.16063417
189detection of mechanical stimulus involved in sensory perception (GO:0050974)2.14277988
190cellular potassium ion transport (GO:0071804)2.14152284
191potassium ion transmembrane transport (GO:0071805)2.14152284
192positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.13267509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.24826913
2SCL_19346495_ChIP-Seq_HPC-7_Human4.28231829
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.11139826
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.05771486
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42561065
6GBX2_23144817_ChIP-Seq_PC3_Human3.25206328
7EZH2_22144423_ChIP-Seq_EOC_Human3.14694764
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.95524037
9GATA1_22025678_ChIP-Seq_K562_Human2.88567903
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.86812838
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86003192
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79200092
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.67591472
14TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.63640922
15* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.50240751
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.49035081
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46836010
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38874855
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.28442147
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26155539
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.24644436
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24250368
23GATA1_22383799_ChIP-Seq_G1ME_Mouse2.21653884
24HOXB4_20404135_ChIP-ChIP_EML_Mouse2.18980510
25GATA1_19941827_ChIP-Seq_MEL_Mouse2.18804892
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13471517
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11094399
28MYC_22102868_ChIP-Seq_BL_Human2.10994350
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09156753
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.08463483
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08457777
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06417514
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04560304
34AR_21909140_ChIP-Seq_LNCAP_Human2.01978689
35E2F1_21310950_ChIP-Seq_MCF-7_Human2.01492059
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98482333
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95554812
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.94379800
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.94026243
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90635886
41VDR_23849224_ChIP-Seq_CD4+_Human1.88949568
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.85284768
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83772316
44CIITA_25753668_ChIP-Seq_RAJI_Human1.79723240
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.79514810
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77028937
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76987645
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76696936
49VDR_21846776_ChIP-Seq_THP-1_Human1.76230076
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75785452
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74733789
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.74162197
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74047147
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.73598335
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73501232
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71032548
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70369077
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67670205
59FOXP3_21729870_ChIP-Seq_TREG_Human1.62395419
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59168103
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58970353
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58789891
63DROSHA_22980978_ChIP-Seq_HELA_Human1.58095052
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56890686
65XRN2_22483619_ChIP-Seq_HELA_Human1.56691028
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.56527368
67SPI1_23547873_ChIP-Seq_NB4_Human1.56512020
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.56404297
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55583004
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55361261
71SMAD4_21799915_ChIP-Seq_A2780_Human1.54648011
72MYB_26560356_Chip-Seq_TH2_Human1.54471555
73RUNX_20019798_ChIP-Seq_JUKART_Human1.54452642
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52948800
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.50800752
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.50590515
77* REST_21632747_ChIP-Seq_MESCs_Mouse1.49683674
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48086524
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.47870007
80ZNF274_21170338_ChIP-Seq_K562_Hela1.47295393
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46604060
82TP53_16413492_ChIP-PET_HCT116_Human1.46355309
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45357858
84STAT3_23295773_ChIP-Seq_U87_Human1.44516340
85* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43976935
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42878578
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42836598
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.42152732
89* GATA1_19941826_ChIP-Seq_K562_Human1.41809310
90* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41622072
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41534069
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40678630
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39722111
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38717403
95TCF4_23295773_ChIP-Seq_U87_Human1.38485136
96MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37877093
97MYB_26560356_Chip-Seq_TH1_Human1.37119612
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36420819
99TAF15_26573619_Chip-Seq_HEK293_Human1.36406287
100NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35631222
101P300_19829295_ChIP-Seq_ESCs_Human1.35473692
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.34575240
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34214785
104MAF_26560356_Chip-Seq_TH1_Human1.32727710
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32075642
106JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31734010
107AR_25329375_ChIP-Seq_VCAP_Human1.31504501
108SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31113610
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29524874
110CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29517521
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28982095
112UTX_26944678_Chip-Seq_JUKART_Human1.27647522
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27525532
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25021982
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24440277
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23997957
117GATA2_21666600_ChIP-Seq_HMVEC_Human1.23142066
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22191006
119* AR_21572438_ChIP-Seq_LNCaP_Human1.22170444
120KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22119837
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21530166
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20694175
123GABP_19822575_ChIP-Seq_HepG2_Human1.20560524
124PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18877230
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.18824524
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.18427360
127VDR_22108803_ChIP-Seq_LS180_Human1.18288165
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.16813898
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16690932
130BCAT_22108803_ChIP-Seq_LS180_Human1.15327325
131* VDR_24763502_ChIP-Seq_THP-1_Human1.15289450
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15175123
133FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14247877
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13609927
135CJUN_26792858_Chip-Seq_BT549_Human1.13428280
136SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13375454
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12000113
138NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12000113
139SMAD3_21741376_ChIP-Seq_EPCs_Human1.11511916
140ER_23166858_ChIP-Seq_MCF-7_Human1.11470783
141SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11152647
142SOX2_21211035_ChIP-Seq_LN229_Gbm1.10579646
143RNF2_27304074_Chip-Seq_ESCs_Mouse1.10500127
144DCP1A_22483619_ChIP-Seq_HELA_Human1.10320733
145JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09355115
146IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09218729
147ELK1_19687146_ChIP-ChIP_HELA_Human1.08976044
148E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08673545
149PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08244453
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08169993
151ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07683989
152WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07495559
153EZH2_27294783_Chip-Seq_NPCs_Mouse1.07376198
154P53_22387025_ChIP-Seq_ESCs_Mouse1.06798299
155TTF2_22483619_ChIP-Seq_HELA_Human1.06018865
156VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05133636
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04845826
158NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02799990
159IGF1R_20145208_ChIP-Seq_DFB_Human1.02296081
160CBP_20019798_ChIP-Seq_JUKART_Human1.02246812
161IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02246812
162EP300_21415370_ChIP-Seq_HL-1_Mouse1.02163195
163ETS1_22383799_ChIP-Seq_G1ME_Mouse1.02069211
164AHR_22903824_ChIP-Seq_MCF-7_Human1.02068510
165* RUNX2_22187159_ChIP-Seq_PCA_Human1.01564768
166MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00920676
167* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00838514
168IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00161715
169BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00013386
170TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99817766
171E2F1_18555785_Chip-Seq_ESCs_Mouse0.99667598
172ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98595182
173CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97788078
174EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97439451
175EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96796510
176NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96214342
177STAT3_18555785_Chip-Seq_ESCs_Mouse0.96201352
178* GATA2_19941826_ChIP-Seq_K562_Human0.95863303
179CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95539493
180CMYC_18555785_Chip-Seq_ESCs_Mouse0.95515132
181CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95353701
182KDM5A_27292631_Chip-Seq_BREAST_Human0.94829463
183CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92411397
184TCF7_22412390_ChIP-Seq_EML_Mouse0.92260522
185CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92196935
186YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91522737
187SPI1_23127762_ChIP-Seq_K562_Human0.90538650
188IRF8_21731497_ChIP-ChIP_J774_Mouse0.88922714
189FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87844340
190YY1_21170310_ChIP-Seq_MESCs_Mouse0.86446086
191KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81687988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.38135077
2MP0002396_abnormal_hematopoietic_system5.00047831
3MP0003656_abnormal_erythrocyte_physiolo4.70024783
4MP0006054_spinal_hemorrhage3.75337689
5MP0009780_abnormal_chondrocyte_physiolo3.74720335
6MP0008057_abnormal_DNA_replication3.17633050
7MP0005397_hematopoietic_system_phenotyp2.99445213
8MP0001545_abnormal_hematopoietic_system2.99445213
9MP0005464_abnormal_platelet_physiology2.90429297
10MP0003693_abnormal_embryo_hatching2.82757376
11MP0000465_gastrointestinal_hemorrhage2.80416467
12MP0003111_abnormal_nucleus_morphology2.76505636
13MP0004859_abnormal_synaptic_plasticity2.74911445
14MP0003763_abnormal_thymus_physiology2.69896331
15MP0010094_abnormal_chromosome_stability2.63540410
16MP0009745_abnormal_behavioral_response2.63024200
17MP0004808_abnormal_hematopoietic_stem2.60937333
18MP0001853_heart_inflammation2.57388396
19MP0010386_abnormal_urinary_bladder2.55621627
20MP0002064_seizures2.35233719
21MP0001905_abnormal_dopamine_level2.34533314
22MP0003635_abnormal_synaptic_transmissio2.32698109
23MP0001501_abnormal_sleep_pattern2.32271228
24MP0002398_abnormal_bone_marrow2.31966566
25MP0002272_abnormal_nervous_system2.31907575
26MP0005671_abnormal_response_to2.31654863
27MP0004885_abnormal_endolymph2.30851272
28MP0001835_abnormal_antigen_presentation2.28501387
29MP0003880_abnormal_central_pattern2.24698295
30MP0003077_abnormal_cell_cycle2.20223829
31MP0008007_abnormal_cellular_replicative2.19158749
32MP0000490_abnormal_crypts_of2.16747192
33MP0008058_abnormal_DNA_repair2.12181643
34MP0004043_abnormal_pH_regulation2.09478680
35MP0000569_abnormal_digit_pigmentation2.09225665
36MP0001486_abnormal_startle_reflex2.04408609
37MP0001968_abnormal_touch/_nociception2.04101188
38MP0009046_muscle_twitch1.94528707
39MP0003045_fibrosis1.94154982
40MP0004270_analgesia1.91085029
41MP0000685_abnormal_immune_system1.90645645
42* MP0000689_abnormal_spleen_morphology1.90455155
43MP0003633_abnormal_nervous_system1.89663826
44* MP0002722_abnormal_immune_system1.87238725
45MP0002132_abnormal_respiratory_system1.85722312
46MP0005174_abnormal_tail_pigmentation1.83729653
47MP0001970_abnormal_pain_threshold1.82423168
48MP0002733_abnormal_thermal_nociception1.80257462
49MP0002006_tumorigenesis1.77515892
50MP0003950_abnormal_plasma_membrane1.76638335
51MP0003879_abnormal_hair_cell1.76229997
52MP0005551_abnormal_eye_electrophysiolog1.75009947
53MP0005075_abnormal_melanosome_morpholog1.74786137
54MP0002166_altered_tumor_susceptibility1.74663263
55MP0002734_abnormal_mechanical_nocicepti1.73507459
56MP0002063_abnormal_learning/memory/cond1.73356838
57MP0002735_abnormal_chemical_nociception1.72491326
58MP0003724_increased_susceptibility_to1.71545625
59MP0001958_emphysema1.66276778
60MP0002429_abnormal_blood_cell1.65751012
61MP0005083_abnormal_biliary_tract1.62448293
62MP0004957_abnormal_blastocyst_morpholog1.61275588
63MP0002572_abnormal_emotion/affect_behav1.60070812
64MP0001800_abnormal_humoral_immune1.59235252
65MP0000703_abnormal_thymus_morphology1.56185797
66MP0003631_nervous_system_phenotype1.55089418
67MP0001756_abnormal_urination1.53836173
68MP0000716_abnormal_immune_system1.53345210
69MP0006292_abnormal_olfactory_placode1.52727920
70MP0002420_abnormal_adaptive_immunity1.50700656
71MP0001873_stomach_inflammation1.48834287
72MP0001819_abnormal_immune_cell1.46470694
73MP0000920_abnormal_myelination1.43469439
74MP0002452_abnormal_antigen_presenting1.43298467
75MP0002723_abnormal_immune_serum1.41752194
76MP0005423_abnormal_somatic_nervous1.41617338
77MP0002405_respiratory_system_inflammati1.40255440
78MP0002067_abnormal_sensory_capabilities1.39544647
79MP0003186_abnormal_redox_activity1.37329297
80MP0010155_abnormal_intestine_physiology1.37289762
81MP0002095_abnormal_skin_pigmentation1.35530992
82MP0004130_abnormal_muscle_cell1.35359856
83MP0009333_abnormal_splenocyte_physiolog1.34033978
84MP0001502_abnormal_circadian_rhythm1.33679251
85MP0002736_abnormal_nociception_after1.29337248
86MP0005000_abnormal_immune_tolerance1.26887972
87MP0004484_altered_response_of1.26788452
88MP0005025_abnormal_response_to1.26648247
89MP0003866_abnormal_defecation1.25976064
90MP0002019_abnormal_tumor_incidence1.25955674
91MP0001984_abnormal_olfaction1.15914078
92MP0005387_immune_system_phenotype1.15604207
93MP0001790_abnormal_immune_system1.15604207
94MP0003329_amyloid_beta_deposits1.15396390
95MP0009764_decreased_sensitivity_to1.15151161
96MP0004924_abnormal_behavior1.14888306
97MP0005386_behavior/neurological_phenoty1.14888306
98MP0009785_altered_susceptibility_to1.14149755
99MP0000538_abnormal_urinary_bladder1.13239910
100MP0008874_decreased_physiological_sensi1.13209239
101MP0002419_abnormal_innate_immunity1.12666745
102MP0004142_abnormal_muscle_tone1.12491752
103MP0003632_abnormal_nervous_system1.10663347
104MP0002332_abnormal_exercise_endurance1.10636818
105MP0003787_abnormal_imprinting1.09004907
106MP0000427_abnormal_hair_cycle1.08429919
107MP0000230_abnormal_systemic_arterial1.06747684
108MP0005595_abnormal_vascular_smooth1.05334890
109MP0005171_absent_coat_pigmentation1.05272384
110MP0008877_abnormal_DNA_methylation1.04786900
111MP0001664_abnormal_digestion1.04726119
112MP0005409_darkened_coat_color1.03441311
113MP0002229_neurodegeneration1.02444744
114MP0005646_abnormal_pituitary_gland1.00080310
115MP0002876_abnormal_thyroid_physiology0.98556483
116MP0003195_calcinosis0.97759691
117MP0001986_abnormal_taste_sensitivity0.97267703
118MP0003279_aneurysm0.96881127
119MP0002557_abnormal_social/conspecific_i0.95391438
120MP0000313_abnormal_cell_death0.94794502
121MP0009379_abnormal_foot_pigmentation0.94582417
122MP0005645_abnormal_hypothalamus_physiol0.94402582
123MP0005253_abnormal_eye_physiology0.93540508
124MP0000749_muscle_degeneration0.92683726
125MP0001529_abnormal_vocalization0.91251922
126MP0001765_abnormal_ion_homeostasis0.91234637
127MP0002168_other_aberrant_phenotype0.89742950
128MP0002066_abnormal_motor_capabilities/c0.88357853
129MP0004085_abnormal_heartbeat0.87066167
130MP0008872_abnormal_physiological_respon0.86589520
131MP0001963_abnormal_hearing_physiology0.85145950
132MP0000350_abnormal_cell_proliferation0.84257944
133MP0000343_altered_response_to0.84046169
134MP0001440_abnormal_grooming_behavior0.83128342
135MP0001845_abnormal_inflammatory_respons0.82499992
136MP0008875_abnormal_xenobiotic_pharmacok0.81845724
137MP0003943_abnormal_hepatobiliary_system0.80511984
138MP0001188_hyperpigmentation0.80407819
139MP0004134_abnormal_chest_morphology0.79885006
140MP0000015_abnormal_ear_pigmentation0.79871626
141MP0003075_altered_response_to0.79730263
142MP0005167_abnormal_blood-brain_barrier0.79151491
143MP0002837_dystrophic_cardiac_calcinosis0.79014157
144MP0001485_abnormal_pinna_reflex0.78641009
145MP0002009_preneoplasia0.78218944
146MP0005620_abnormal_muscle_contractility0.76453436
147MP0010352_gastrointestinal_tract_polyps0.76255342
148MP0002148_abnormal_hypersensitivity_rea0.75699383
149MP0003183_abnormal_peptide_metabolism0.74984010
150MP0006036_abnormal_mitochondrial_physio0.74751038
151MP0002877_abnormal_melanocyte_morpholog0.74029779
152MP0002882_abnormal_neuron_morphology0.72812379
153MP0008469_abnormal_protein_level0.72253723
154MP0002928_abnormal_bile_duct0.71153196
155MP0004215_abnormal_myocardial_fiber0.70541284
156MP0006276_abnormal_autonomic_nervous0.68757384
157MP0004036_abnormal_muscle_relaxation0.67403914
158MP0003634_abnormal_glial_cell0.66914399
159MP0003300_gastrointestinal_ulcer0.66401076
160MP0001915_intracranial_hemorrhage0.66270216
161MP0005164_abnormal_response_to0.66138084
162MP0009278_abnormal_bone_marrow0.66052261
163MP0003172_abnormal_lysosome_physiology0.65869094
164MP0002653_abnormal_ependyma_morphology0.64635358
165MP0000631_abnormal_neuroendocrine_gland0.64260961
166MP0005636_abnormal_mineral_homeostasis0.63825014
167MP0004811_abnormal_neuron_physiology0.63644093
168MP0008789_abnormal_olfactory_epithelium0.62015769
169MP0008932_abnormal_embryonic_tissue0.61343252
170MP0000858_altered_metastatic_potential0.60626111
171MP0002089_abnormal_postnatal_growth/wei0.60553640
172MP0001764_abnormal_homeostasis0.59471887
173MP0003690_abnormal_glial_cell0.59161254
174MP0001663_abnormal_digestive_system0.59129601
175MP0008770_decreased_survivor_rate0.56975738
176MP0009763_increased_sensitivity_to0.55548278
177MP0005394_taste/olfaction_phenotype0.54658944
178MP0005499_abnormal_olfactory_system0.54658944
179MP0003786_premature_aging0.53333378
180MP0010307_abnormal_tumor_latency0.52857441
181MP0008569_lethality_at_weaning0.52058757
182MP0000477_abnormal_intestine_morphology0.50629703
183MP0005310_abnormal_salivary_gland0.47508755
184MP0009765_abnormal_xenobiotic_induced0.47184039

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)8.21708430
2Petechiae (HP:0000967)8.12053110
3Prolonged bleeding time (HP:0003010)7.37129563
4Purpura (HP:0000979)6.08752380
5Abnormal platelet volume (HP:0011876)5.78731153
6Hypochromic microcytic anemia (HP:0004840)5.72565909
7Increased mean platelet volume (HP:0011877)5.72249442
8Chronic otitis media (HP:0000389)5.46179998
9Poikilocytosis (HP:0004447)5.32661872
10Abnormal number of erythroid precursors (HP:0012131)5.24627612
11Aplastic anemia (HP:0001915)4.84221777
12Abnormality of cells of the erythroid lineage (HP:0012130)4.82213089
13Abnormality of binocular vision (HP:0011514)4.36275758
14Diplopia (HP:0000651)4.36275758
15Menorrhagia (HP:0000132)4.32665888
16Epistaxis (HP:0000421)4.25355101
17Focal motor seizures (HP:0011153)4.12362500
18Focal seizures (HP:0007359)3.90911066
19Hemiparesis (HP:0001269)3.85559385
20Febrile seizures (HP:0002373)3.72728610
21Increased circulating renin level (HP:0000848)3.68288684
22Gingival bleeding (HP:0000225)3.65948449
23Acanthocytosis (HP:0001927)3.52043394
24Hypokalemic alkalosis (HP:0001949)3.45568077
25IgM deficiency (HP:0002850)3.44085786
26Metabolic alkalosis (HP:0200114)3.41155790
27Polydipsia (HP:0001959)3.25562481
28Abnormal drinking behavior (HP:0030082)3.25562481
29Progressive cerebellar ataxia (HP:0002073)3.25553243
30Hyperventilation (HP:0002883)3.21549204
31Panhypogammaglobulinemia (HP:0003139)3.20495542
32Hypochromic anemia (HP:0001931)3.17635820
33Dialeptic seizures (HP:0011146)3.13951808
34Abnormal platelet function (HP:0011869)3.09426504
35Impaired platelet aggregation (HP:0003540)3.09426504
36Agammaglobulinemia (HP:0004432)3.05095261
37Reticulocytopenia (HP:0001896)3.00161821
38Short middle phalanx of the 5th finger (HP:0004220)2.96661374
39Recurrent viral infections (HP:0004429)2.94437544
40Gaze-evoked nystagmus (HP:0000640)2.93907075
41Thrombocytosis (HP:0001894)2.88737464
42Visual hallucinations (HP:0002367)2.83359580
43Acute lymphatic leukemia (HP:0006721)2.82570771
44Pallor (HP:0000980)2.81912216
45Hypomagnesemia (HP:0002917)2.78937043
46Postural instability (HP:0002172)2.77329625
47Absence seizures (HP:0002121)2.77186654
48Volvulus (HP:0002580)2.75125114
49Atonic seizures (HP:0010819)2.74612856
50Epileptic encephalopathy (HP:0200134)2.71678467
51Megalencephaly (HP:0001355)2.66137153
52Hemiplegia (HP:0002301)2.65841065
53Polyuria (HP:0000103)2.64525850
5411 pairs of ribs (HP:0000878)2.64107391
55Cellulitis (HP:0100658)2.63860635
56Congenital stationary night blindness (HP:0007642)2.62894337
57Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.61434546
58Genetic anticipation (HP:0003743)2.59285912
59Abnormality of reticulocytes (HP:0004312)2.56069412
60Acute myeloid leukemia (HP:0004808)2.54055915
61Oral leukoplakia (HP:0002745)2.53895944
62Absent speech (HP:0001344)2.53429675
63Birth length less than 3rd percentile (HP:0003561)2.50555179
64Type 2 muscle fiber atrophy (HP:0003554)2.49813995
65Myelodysplasia (HP:0002863)2.48908434
66Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.39200252
67Abnormality of the prostate (HP:0008775)2.38078637
68Action tremor (HP:0002345)2.37931054
69Muscle fiber atrophy (HP:0100295)2.36469254
70Reduced antithrombin III activity (HP:0001976)2.31834562
71Reticulocytosis (HP:0001923)2.31267432
72Increased serum ferritin (HP:0003281)2.31205828
73Stomach cancer (HP:0012126)2.31178306
74Recurrent bronchitis (HP:0002837)2.30985994
75Pancytopenia (HP:0001876)2.29669815
76Pancreatic cysts (HP:0001737)2.27284014
77Clumsiness (HP:0002312)2.26962026
78Abnormality of the fingertips (HP:0001211)2.25104567
79Abnormality of the columella (HP:0009929)2.24586806
80Abnormality of the renal cortex (HP:0011035)2.22192118
81Type I transferrin isoform profile (HP:0003642)2.20003332
82Abnormal hemoglobin (HP:0011902)2.17898034
83Selective tooth agenesis (HP:0001592)2.17691713
84Generalized tonic-clonic seizures (HP:0002069)2.17560292
85Hyperaldosteronism (HP:0000859)2.17539446
86Encephalitis (HP:0002383)2.17273071
87Abnormal eating behavior (HP:0100738)2.16070424
88Hematochezia (HP:0002573)2.16003582
89Abnormality of magnesium homeostasis (HP:0004921)2.15677492
90Type II lissencephaly (HP:0007260)2.14498696
91Abnormal urine output (HP:0012590)2.13707197
92Amelogenesis imperfecta (HP:0000705)2.11718787
93Microcytic anemia (HP:0001935)2.10669670
94Pancreatic fibrosis (HP:0100732)2.10443185
95Macrocytic anemia (HP:0001972)2.09212077
96Hyperbilirubinemia (HP:0002904)2.07032059
97Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.05445531
98Severe visual impairment (HP:0001141)2.03037784
99Attenuation of retinal blood vessels (HP:0007843)2.02600072
100Ankle clonus (HP:0011448)2.02061615
101Albinism (HP:0001022)2.01524780
102Recurrent abscess formation (HP:0002722)2.00954240
103Glucose intolerance (HP:0000833)2.00787844
104Abnormality of lateral ventricle (HP:0030047)1.96924936
105Dysdiadochokinesis (HP:0002075)1.96579858
106Abnormality of renin-angiotensin system (HP:0000847)1.96374347
107Supranuclear gaze palsy (HP:0000605)1.95780276
108Prolonged QT interval (HP:0001657)1.95760414
109Onycholysis (HP:0001806)1.95463240
110Lymphoma (HP:0002665)1.95387610
111Aortic aneurysm (HP:0004942)1.95336817
112Abnormality of midbrain morphology (HP:0002418)1.93218254
113Molar tooth sign on MRI (HP:0002419)1.93218254
114Bundle branch block (HP:0011710)1.91274172
115Protruding tongue (HP:0010808)1.91210405
116Abnormality of the phalanges of the 5th finger (HP:0004213)1.90386780
117Exertional dyspnea (HP:0002875)1.90370252
118Abnormality of the renal medulla (HP:0100957)1.89908075
119Nephronophthisis (HP:0000090)1.89151881
120True hermaphroditism (HP:0010459)1.88956069
121Facial shape deformation (HP:0011334)1.88856439
122Potter facies (HP:0002009)1.88856439
123Abnormality of renal excretion (HP:0011036)1.88845736
124Hyperkalemia (HP:0002153)1.88706208
125Obstructive sleep apnea (HP:0002870)1.88526057
126Abnormality of iron homeostasis (HP:0011031)1.88062607
127Abnormal protein glycosylation (HP:0012346)1.86973486
128Abnormal glycosylation (HP:0012345)1.86973486
129Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86973486
130Abnormal protein N-linked glycosylation (HP:0012347)1.86973486
131Increased hepatocellular lipid droplets (HP:0006565)1.85876393
132Bruising susceptibility (HP:0000978)1.84530201
133IgG deficiency (HP:0004315)1.83898158
134Anxiety (HP:0000739)1.83182373
135Recurrent bacterial skin infections (HP:0005406)1.81967232
136Atrial fibrillation (HP:0005110)1.81352832
137Large for gestational age (HP:0001520)1.79269189
138Abnormality of chloride homeostasis (HP:0011422)1.78104670
139Primary atrial arrhythmia (HP:0001692)1.77840597
140Generalized hypopigmentation of hair (HP:0011358)1.77642348
141Bone marrow hypocellularity (HP:0005528)1.76573352
142Hypoplasia of the thymus (HP:0000778)1.76135536
143Delusions (HP:0000746)1.74685995
144Decreased central vision (HP:0007663)1.74595376
145Fair hair (HP:0002286)1.74328612
146Ocular albinism (HP:0001107)1.73655238
147Neutropenia (HP:0001875)1.73390486
148Increased CSF protein (HP:0002922)1.73304739
149Sleep apnea (HP:0010535)1.72998801
150Papilledema (HP:0001085)1.72684627
151Widely spaced teeth (HP:0000687)1.71479943
152Epileptiform EEG discharges (HP:0011182)1.71439112
153Palpebral edema (HP:0100540)1.70627579
154Intention tremor (HP:0002080)1.70543978
155Blepharitis (HP:0000498)1.70278397
156Episodic fever (HP:0001954)1.70207499
157Hepatocellular necrosis (HP:0001404)1.69426358
158Abnormal spermatogenesis (HP:0008669)1.69261993
159Abnormality of T cell physiology (HP:0011840)1.68615307
160Long eyelashes (HP:0000527)1.68564121
161Metaphyseal dysplasia (HP:0100255)1.68506291
162Congenital sensorineural hearing impairment (HP:0008527)1.68386490
163Tubular atrophy (HP:0000092)1.67898846
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67719502
165Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67719502
166Chromsome breakage (HP:0040012)1.67428082
167Lymphopenia (HP:0001888)1.66397820
168Truncal ataxia (HP:0002078)1.66258817
169Renal salt wasting (HP:0000127)1.66018866
170Respiratory difficulties (HP:0002880)1.65820086
171Microvesicular hepatic steatosis (HP:0001414)1.64255159
172Neurofibrillary tangles (HP:0002185)1.64150319
173Viral hepatitis (HP:0006562)1.62008771
174Meningitis (HP:0001287)1.61659096
175Increased intramyocellular lipid droplets (HP:0012240)1.61170938
176Abnormality of T cells (HP:0002843)1.61124686
177Keratoconus (HP:0000563)1.61110545
178Increased corneal curvature (HP:0100692)1.61110545
179Polycythemia (HP:0001901)1.60577590
180Hypoplastic iliac wings (HP:0002866)1.60332171
181Supraventricular tachycardia (HP:0004755)1.60222260
182Toxemia of pregnancy (HP:0100603)1.60088543
183Neoplasm of the heart (HP:0100544)1.59689405
184Abnormality of potassium homeostasis (HP:0011042)1.59269078
185Myositis (HP:0100614)1.59094778
186Patchy hypopigmentation of hair (HP:0011365)1.59013186
187Torticollis (HP:0000473)1.58639787
188Abnormality of chromosome stability (HP:0003220)1.57491975
189Fatigue (HP:0012378)1.55928527
190Clubbing of toes (HP:0100760)1.55450954
191Aplasia/Hypoplasia of the sacrum (HP:0008517)1.55176633
192Recurrent fungal infections (HP:0002841)1.53883290
193Abnormal delayed hypersensitivity skin test (HP:0002963)1.53724854
194Elevated erythrocyte sedimentation rate (HP:0003565)1.53647596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.73848621
2TNIK3.88516746
3MAP4K13.33975456
4CDC73.02744670
5CCNB12.92178985
6KIT2.72756947
7TEC2.60634614
8PINK12.54327354
9MUSK2.49305281
10VRK12.38187247
11WEE12.37522262
12PTK2B2.33305055
13BUB12.31563369
14NTRK32.29039770
15TXK2.21934619
16BTK2.21471621
17GRK52.11412960
18EEF2K2.05339828
19TSSK62.02836853
20PAK32.00436838
21MAPKAPK51.99550931
22NME21.88170650
23ADRBK21.88142294
24EPHA41.82048902
25PAK61.81777081
26PHKG21.79221100
27PHKG11.79221100
28DAPK21.79112578
29JAK31.75820768
30STK41.72399802
31PLK21.71428771
32WNK31.68925944
33SGK21.64892612
34STK161.64672037
35EIF2AK11.62323481
36MYLK1.58838514
37MST41.57366880
38STK101.56880934
39STK381.55432041
40MATK1.52207066
41RPS6KB21.49033889
42PIM21.48332638
43SYK1.45719723
44MAPK131.45608133
45CDK191.45299387
46MARK11.43537077
47CASK1.41349723
48TLK11.36998684
49ADRBK11.34115348
50FGFR21.31809405
51CAMKK21.30546758
52KDR1.30333163
53GRK11.29470154
54LMTK21.29053210
55SGK31.28152494
56PLK41.27771821
57SGK2231.25404104
58SGK4941.25404104
59MKNK11.25252372
60ZAK1.21302365
61CDK81.21016749
62AKT31.19637941
63ITK1.18051335
64ATR1.17258439
65CDK41.15802236
66TAOK31.15785313
67WNK11.13280336
68ZAP701.12899863
69BRSK21.12686435
70SCYL21.12376899
71PIM11.11632939
72NEK21.11096125
73CLK11.10634218
74TNK21.08736658
75MAP4K21.08557931
76LYN1.08303026
77CDK71.08028263
78CSF1R1.07546133
79OXSR11.06460959
80LRRK21.05198715
81AURKB1.04536620
82JAK11.00731532
83MKNK21.00511531
84NTRK20.98727015
85IKBKE0.96510850
86SGK10.95968652
87TYK20.95653139
88GRK60.93536129
89STK110.90562466
90CAMK2A0.89380378
91PRKD20.86758896
92BRSK10.86276841
93CAMK10.85499112
94ROCK10.84888902
95DYRK30.84301903
96MAP2K10.83391912
97MAP3K130.83176010
98LIMK10.83125150
99PIK3CG0.82000672
100UHMK10.80232783
101CAMKK10.79109926
102FLT30.78772920
103MAP3K80.78154735
104TBK10.77539879
105PRKD30.75892545
106TTK0.74984586
107STK30.74429030
108MAP2K60.74397386
109PRKCE0.73393188
110FGFR30.69114337
111PIK3CA0.68834211
112LCK0.67656246
113MAPK110.66866889
114WNK40.66543758
115NLK0.64344566
116FES0.63622915
117ACVR1B0.62369468
118MAP3K60.62007327
119PLK10.61844198
120MAP2K30.61272146
121INSRR0.61180199
122PRKCH0.60910227
123CAMK40.60905350
124MARK30.60675391
125STK240.60507322
126NTRK10.60074056
127BMPR1B0.59846649
128CAMK2B0.59806165
129IKBKB0.59528246
130SRPK10.58225959
131MAP3K120.56888828
132ROCK20.56058765
133HIPK20.55809033
134RPS6KA50.55259536
135TIE10.55247632
136STK38L0.54864509
137BMX0.54607143
138PRKCG0.54242869
139CDK50.53163534
140PDK10.53058896
141GRK70.52862269
142EIF2AK30.52411588
143MAPK120.52384876
144NEK10.51815924
145PASK0.51481191
146TGFBR10.51204125
147CAMK2D0.51194335
148MAPK40.50397741
149PRKD10.50110906
150KSR10.49857399
151DYRK1A0.49558103
152BMPR20.48821694
153NME10.47940114
154TAOK10.46781985
155IRAK40.46676016
156PRKCZ0.46611394
157MARK20.44945689
158MET0.44940696
159MINK10.44926428
160CHEK10.44053404
161DMPK0.44004956
162PRKG10.42740344
163BLK0.42468091
164MAP3K70.42032206
165ATM0.41882905
166TAOK20.41503184
167MAP3K40.40635655
168RAF10.40122870
169PRKG20.39655002
170CAMK2G0.39421360
171CDK60.39197475
172JAK20.38565240
173MELK0.38407360
174TRPM70.37741662
175NUAK10.36789500
176RPS6KB10.35719158
177MAP2K70.33531248
178CHEK20.32870205
179RPS6KA40.32779054
180PRKCQ0.31842487
181TRIB30.31798736
182CDK20.31248038

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.44671564
2Mismatch repair_Homo sapiens_hsa034303.61255025
3Ribosome_Homo sapiens_hsa030103.55025859
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.01841922
5Hematopoietic cell lineage_Homo sapiens_hsa046402.89343436
6Base excision repair_Homo sapiens_hsa034102.70497660
7Homologous recombination_Homo sapiens_hsa034402.48322070
8Cell cycle_Homo sapiens_hsa041102.46758859
9Insulin secretion_Homo sapiens_hsa049112.37562713
10Nicotine addiction_Homo sapiens_hsa050332.36367916
11Morphine addiction_Homo sapiens_hsa050322.25630001
12Circadian entrainment_Homo sapiens_hsa047132.22282667
13Nucleotide excision repair_Homo sapiens_hsa034202.20374465
14Primary immunodeficiency_Homo sapiens_hsa053402.18549471
15Spliceosome_Homo sapiens_hsa030402.11134340
16Pyrimidine metabolism_Homo sapiens_hsa002402.10998849
17GABAergic synapse_Homo sapiens_hsa047272.09070891
18Salivary secretion_Homo sapiens_hsa049702.07974979
19Systemic lupus erythematosus_Homo sapiens_hsa053221.88370979
20Platelet activation_Homo sapiens_hsa046111.88071963
21RNA polymerase_Homo sapiens_hsa030201.87849113
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81368682
23Glutamatergic synapse_Homo sapiens_hsa047241.79793040
24RNA degradation_Homo sapiens_hsa030181.78858388
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75582081
26Phototransduction_Homo sapiens_hsa047441.74258902
27Gastric acid secretion_Homo sapiens_hsa049711.73122232
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72684305
29p53 signaling pathway_Homo sapiens_hsa041151.67634247
30Renin secretion_Homo sapiens_hsa049241.67620868
31Non-homologous end-joining_Homo sapiens_hsa034501.66037768
32Amphetamine addiction_Homo sapiens_hsa050311.64035296
33Calcium signaling pathway_Homo sapiens_hsa040201.59437045
34One carbon pool by folate_Homo sapiens_hsa006701.58367538
35Herpes simplex infection_Homo sapiens_hsa051681.52708886
36Synaptic vesicle cycle_Homo sapiens_hsa047211.52062452
37Fanconi anemia pathway_Homo sapiens_hsa034601.48530728
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45569330
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44350762
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42700362
41Measles_Homo sapiens_hsa051621.42670073
42Circadian rhythm_Homo sapiens_hsa047101.41626194
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.40184391
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40136125
45Dopaminergic synapse_Homo sapiens_hsa047281.38414302
46Long-term potentiation_Homo sapiens_hsa047201.38063822
47Antigen processing and presentation_Homo sapiens_hsa046121.37113952
48RNA transport_Homo sapiens_hsa030131.35867614
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33810220
50cAMP signaling pathway_Homo sapiens_hsa040241.33460913
51N-Glycan biosynthesis_Homo sapiens_hsa005101.31809835
52Dorso-ventral axis formation_Homo sapiens_hsa043201.31226380
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30222303
54Taste transduction_Homo sapiens_hsa047421.30117090
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26284140
56Olfactory transduction_Homo sapiens_hsa047401.25471061
57Regulation of autophagy_Homo sapiens_hsa041401.23727714
58B cell receptor signaling pathway_Homo sapiens_hsa046621.23459125
59Cocaine addiction_Homo sapiens_hsa050301.22687842
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21833032
61Oxytocin signaling pathway_Homo sapiens_hsa049211.21045882
62Cholinergic synapse_Homo sapiens_hsa047251.20818587
63Serotonergic synapse_Homo sapiens_hsa047261.20764619
64Collecting duct acid secretion_Homo sapiens_hsa049661.15683140
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14233747
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12517516
67Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10987983
68Long-term depression_Homo sapiens_hsa047301.10925005
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10145148
70Purine metabolism_Homo sapiens_hsa002301.09747223
71NF-kappa B signaling pathway_Homo sapiens_hsa040641.09441145
72cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09282843
73Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08331948
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07950955
75Pancreatic secretion_Homo sapiens_hsa049721.07829372
76Small cell lung cancer_Homo sapiens_hsa052221.04683766
77Sulfur relay system_Homo sapiens_hsa041221.02667824
78Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01981606
79Linoleic acid metabolism_Homo sapiens_hsa005911.01807375
80Folate biosynthesis_Homo sapiens_hsa007901.00918980
81Basal transcription factors_Homo sapiens_hsa030221.00042461
82Bile secretion_Homo sapiens_hsa049760.98631205
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97135850
84Viral carcinogenesis_Homo sapiens_hsa052030.97110726
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96517170
86African trypanosomiasis_Homo sapiens_hsa051430.95275064
87Ether lipid metabolism_Homo sapiens_hsa005650.94317207
88ABC transporters_Homo sapiens_hsa020100.90927761
89Hepatitis B_Homo sapiens_hsa051610.88888016
90Dilated cardiomyopathy_Homo sapiens_hsa054140.88722943
91Leishmaniasis_Homo sapiens_hsa051400.88373120
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.88079429
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.87706648
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87483301
95Butanoate metabolism_Homo sapiens_hsa006500.87227962
96Fatty acid biosynthesis_Homo sapiens_hsa000610.87174872
97Alcoholism_Homo sapiens_hsa050340.86611393
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84072732
99Malaria_Homo sapiens_hsa051440.82532678
100Inositol phosphate metabolism_Homo sapiens_hsa005620.81446902
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.80252485
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80032428
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77243011
104Ovarian steroidogenesis_Homo sapiens_hsa049130.77105602
105Histidine metabolism_Homo sapiens_hsa003400.76250515
106Influenza A_Homo sapiens_hsa051640.75603406
107Chronic myeloid leukemia_Homo sapiens_hsa052200.75219625
108Ras signaling pathway_Homo sapiens_hsa040140.75158437
109Non-small cell lung cancer_Homo sapiens_hsa052230.75143997
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74915033
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72838855
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.71438743
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71421821
114MAPK signaling pathway_Homo sapiens_hsa040100.71125394
115ECM-receptor interaction_Homo sapiens_hsa045120.70638578
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.69553899
117Arachidonic acid metabolism_Homo sapiens_hsa005900.69304781
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69158542
119Acute myeloid leukemia_Homo sapiens_hsa052210.68892634
120beta-Alanine metabolism_Homo sapiens_hsa004100.68652461
121Pentose phosphate pathway_Homo sapiens_hsa000300.68573085
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68235350
123Mineral absorption_Homo sapiens_hsa049780.67580484
124Epstein-Barr virus infection_Homo sapiens_hsa051690.67133249
125GnRH signaling pathway_Homo sapiens_hsa049120.67105025
126Toxoplasmosis_Homo sapiens_hsa051450.65132726
127Apoptosis_Homo sapiens_hsa042100.64962461
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63753424
129Estrogen signaling pathway_Homo sapiens_hsa049150.63467110
130Tryptophan metabolism_Homo sapiens_hsa003800.63355463
131Proteasome_Homo sapiens_hsa030500.62139889
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60709473
133mRNA surveillance pathway_Homo sapiens_hsa030150.60635159
134Pancreatic cancer_Homo sapiens_hsa052120.60331502
135FoxO signaling pathway_Homo sapiens_hsa040680.58528832
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57575627
137Rap1 signaling pathway_Homo sapiens_hsa040150.57494544
138Shigellosis_Homo sapiens_hsa051310.56563596
139Thyroid hormone synthesis_Homo sapiens_hsa049180.55369966
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.54252046
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53360841
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52769001
143HTLV-I infection_Homo sapiens_hsa051660.51675901
144Legionellosis_Homo sapiens_hsa051340.51444792
145mTOR signaling pathway_Homo sapiens_hsa041500.51135503
146Glioma_Homo sapiens_hsa052140.50016685
147Gap junction_Homo sapiens_hsa045400.48901713
148Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48166752
149Thyroid cancer_Homo sapiens_hsa052160.46943426
150Choline metabolism in cancer_Homo sapiens_hsa052310.46646232
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46580371
152Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45343024
153Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45330477
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.44564369
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44064090
156Osteoclast differentiation_Homo sapiens_hsa043800.43593447
157Endocytosis_Homo sapiens_hsa041440.42788954
158Melanoma_Homo sapiens_hsa052180.42736409
159Other glycan degradation_Homo sapiens_hsa005110.41310766
160Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39965138
161Focal adhesion_Homo sapiens_hsa045100.38796995
162Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38717462
163Glucagon signaling pathway_Homo sapiens_hsa049220.38430390
164Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36427359
165Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36370051
166Caffeine metabolism_Homo sapiens_hsa002320.32084776
167Nitrogen metabolism_Homo sapiens_hsa009100.30986821
168NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30856972
169Drug metabolism - other enzymes_Homo sapiens_hsa009830.29746934
170Tuberculosis_Homo sapiens_hsa051520.28647061
171T cell receptor signaling pathway_Homo sapiens_hsa046600.26589450
172Oocyte meiosis_Homo sapiens_hsa041140.25655928
173Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22273665
174Galactose metabolism_Homo sapiens_hsa000520.22061299
175Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20305822
176Protein export_Homo sapiens_hsa030600.17766880
177Hepatitis C_Homo sapiens_hsa051600.17708528
178Metabolic pathways_Homo sapiens_hsa011000.15106127
179Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14173962
180Colorectal cancer_Homo sapiens_hsa052100.13578183
181Chemokine signaling pathway_Homo sapiens_hsa040620.11162717

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