SLC13A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.71229864
2regulation of response to osmotic stress (GO:0047484)6.22565772
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.08446414
4regulation of nuclear cell cycle DNA replication (GO:0033262)5.81288500
5epithelial cilium movement (GO:0003351)5.51054980
6behavioral response to nicotine (GO:0035095)5.33182014
7cilium movement (GO:0003341)5.14198474
8somite rostral/caudal axis specification (GO:0032525)5.10500076
9regulation of mammary gland epithelial cell proliferation (GO:0033599)5.07337626
10notochord development (GO:0030903)4.86301063
11histone H4-K12 acetylation (GO:0043983)4.84113274
12negative regulation of telomerase activity (GO:0051974)4.76889583
13mitochondrion distribution (GO:0048311)4.73416709
14cilium or flagellum-dependent cell motility (GO:0001539)4.72105705
15positive regulation of DNA-dependent DNA replication (GO:2000105)4.59226453
16regulation of MHC class I biosynthetic process (GO:0045343)4.55175219
17regulation of telomere maintenance via telomerase (GO:0032210)4.49080612
18astrocyte development (GO:0014002)4.42607179
19rRNA methylation (GO:0031167)4.39653919
20axonemal dynein complex assembly (GO:0070286)4.38465732
21rRNA modification (GO:0000154)4.31816012
22regulation of apoptotic process involved in morphogenesis (GO:1902337)4.29984220
23presynaptic membrane assembly (GO:0097105)4.29332590
24interferon-gamma production (GO:0032609)4.26909550
25maintenance of protein location in nucleus (GO:0051457)4.24233940
26negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.17142382
27negative regulation of epidermis development (GO:0045683)4.07614223
28axoneme assembly (GO:0035082)4.00888939
29regulation of G0 to G1 transition (GO:0070316)3.99941396
30negative regulation of telomere maintenance (GO:0032205)3.97711195
31L-fucose catabolic process (GO:0042355)3.94561465
32fucose catabolic process (GO:0019317)3.94561465
33L-fucose metabolic process (GO:0042354)3.94561465
34histone H4-K8 acetylation (GO:0043982)3.92721241
35histone H4-K5 acetylation (GO:0043981)3.92721241
36nonmotile primary cilium assembly (GO:0035058)3.91365280
37kidney morphogenesis (GO:0060993)3.85447165
38DNA replication checkpoint (GO:0000076)3.82685235
39regulation of cilium movement (GO:0003352)3.79244618
40presynaptic membrane organization (GO:0097090)3.71526344
41quinone metabolic process (GO:1901661)3.70796144
42rRNA transcription (GO:0009303)3.64373635
43negative regulation of cell cycle G2/M phase transition (GO:1902750)3.63895295
44postsynaptic membrane organization (GO:0001941)3.54128018
45cyclooxygenase pathway (GO:0019371)3.52021714
46cilium morphogenesis (GO:0060271)3.50110896
47negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.49471336
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.47065787
49cullin deneddylation (GO:0010388)3.45027149
50astrocyte differentiation (GO:0048708)3.44875815
51cilium organization (GO:0044782)3.42338849
52neural tube formation (GO:0001841)3.42067510
53ventricular system development (GO:0021591)3.41682647
54cilium assembly (GO:0042384)3.37441416
55vitamin A metabolic process (GO:0006776)3.36651877
56omega-hydroxylase P450 pathway (GO:0097267)3.35143528
57atrial cardiac muscle cell action potential (GO:0086014)3.35140585
58protein polyglutamylation (GO:0018095)3.34235381
59receptor recycling (GO:0001881)3.31111288
60nucleoside transmembrane transport (GO:1901642)3.28319087
61piRNA metabolic process (GO:0034587)3.26779503
62negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.25124938
63regulation of microtubule-based movement (GO:0060632)3.24259883
64urinary tract smooth muscle contraction (GO:0014848)3.22660032
65neurotransmitter uptake (GO:0001504)3.19544709
66regulation of translation in response to stress (GO:0043555)3.18907222
67cell proliferation involved in metanephros development (GO:0072203)3.18823101
68regulation of telomerase activity (GO:0051972)3.17246954
69phenol-containing compound catabolic process (GO:0019336)3.16048354
70neuron cell-cell adhesion (GO:0007158)3.11190728
71response to dietary excess (GO:0002021)3.09882021
72intraciliary transport (GO:0042073)3.06972516
73muscle organ morphogenesis (GO:0048644)3.04932228
74branching involved in mammary gland duct morphogenesis (GO:0060444)3.04789382
75retinal cone cell development (GO:0046549)3.04378587
76positive regulation of developmental pigmentation (GO:0048087)3.04308914
77DNA damage response, detection of DNA damage (GO:0042769)3.02814828
78photoreceptor cell maintenance (GO:0045494)3.02061501
79detection of light stimulus involved in sensory perception (GO:0050962)3.00452681
80detection of light stimulus involved in visual perception (GO:0050908)3.00452681
81cytidine deamination (GO:0009972)3.00307992
82cytidine metabolic process (GO:0046087)3.00307992
83cytidine catabolic process (GO:0006216)3.00307992
84bone trabecula formation (GO:0060346)2.99693045
85regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.98874602
86centriole replication (GO:0007099)2.98584508
87negative regulation of systemic arterial blood pressure (GO:0003085)2.96069699
88regulation of hippo signaling (GO:0035330)2.94397688
89DNA methylation involved in gamete generation (GO:0043046)2.93784822
90protein deneddylation (GO:0000338)2.93236521
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.92682697
92DNA deamination (GO:0045006)2.92369585
93phagocytosis, recognition (GO:0006910)2.90868819
94negative regulation of keratinocyte proliferation (GO:0010839)2.90349534
95motile cilium assembly (GO:0044458)2.88291051
96regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.85981448
97protein localization to kinetochore (GO:0034501)2.85335301
98neuron fate determination (GO:0048664)2.83922248
99cornea development in camera-type eye (GO:0061303)2.83539715
100negative regulation of epidermal cell differentiation (GO:0045605)2.82040229
101cell fate commitment involved in formation of primary germ layer (GO:0060795)2.81986029
102protein K11-linked deubiquitination (GO:0035871)2.81730415
103cellular ketone body metabolic process (GO:0046950)2.79865607
104serotonin receptor signaling pathway (GO:0007210)2.78732799
105nucleoside transport (GO:0015858)2.78513995
106female genitalia development (GO:0030540)2.77667673
107limb bud formation (GO:0060174)2.77350807
108negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.76562137
109negative regulation of translation, ncRNA-mediated (GO:0040033)2.76562137
110regulation of translation, ncRNA-mediated (GO:0045974)2.76562137
111spinal cord motor neuron differentiation (GO:0021522)2.76127162
112regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.75255344
113cardiovascular system development (GO:0072358)2.74995730
114regulation of telomere maintenance (GO:0032204)2.74549175
115negative regulation of signal transduction by p53 class mediator (GO:1901797)2.73669736
116glycerophospholipid catabolic process (GO:0046475)2.73515556
117gamma-aminobutyric acid transport (GO:0015812)2.73483403
118multicellular organism reproduction (GO:0032504)2.72964977
119natural killer cell activation involved in immune response (GO:0002323)2.72778097
120cellular component assembly involved in morphogenesis (GO:0010927)2.72727850
121smoothened signaling pathway (GO:0007224)2.72287625
122regulation of pigment cell differentiation (GO:0050932)2.72166536
123mitochondrial DNA replication (GO:0006264)2.71331551
124photoreceptor cell development (GO:0042461)2.71251939
125hormone catabolic process (GO:0042447)2.70397624
126regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.69959459
127positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.69959459
128transmission of nerve impulse (GO:0019226)2.69687860
129mitotic sister chromatid segregation (GO:0000070)2.69489955
130cell proliferation involved in kidney development (GO:0072111)2.69221469
131response to pheromone (GO:0019236)2.68291893
132axon ensheathment in central nervous system (GO:0032291)2.67927109
133central nervous system myelination (GO:0022010)2.67927109
134diterpenoid biosynthetic process (GO:0016102)2.65928155
135regulation of double-strand break repair via homologous recombination (GO:0010569)2.65132889
136mitotic G2/M transition checkpoint (GO:0044818)2.64509906
137peristalsis (GO:0030432)2.63329668
138determination of left/right symmetry (GO:0007368)2.62995338
139vocalization behavior (GO:0071625)2.61944581
140neuronal action potential (GO:0019228)2.60403947
141pyrimidine nucleobase catabolic process (GO:0006208)2.59834221
142calcium-mediated signaling using intracellular calcium source (GO:0035584)2.59440076
143negative regulation of leukocyte chemotaxis (GO:0002689)2.59263321
144histone H4-K16 acetylation (GO:0043984)2.59062645
145negative regulation of interleukin-2 production (GO:0032703)2.58960205
146positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.58727740
147protein localization to cilium (GO:0061512)2.58722028
148terpenoid biosynthetic process (GO:0016114)2.57650949
149regulation of meiosis I (GO:0060631)2.57074695
150transepithelial transport (GO:0070633)2.55107611
151indolalkylamine metabolic process (GO:0006586)2.54352768
152eye photoreceptor cell development (GO:0042462)2.54004151
153negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.53688354
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.53628921
155GDP-mannose metabolic process (GO:0019673)2.53592800
156DNA double-strand break processing (GO:0000729)2.53574644
157regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.53304011
158ribosome biogenesis (GO:0042254)2.53217136
159ketone body metabolic process (GO:1902224)2.52966712
160cell differentiation in spinal cord (GO:0021515)2.52724652
161positive regulation of oligodendrocyte differentiation (GO:0048714)2.52472215
162mitochondrial respiratory chain complex I assembly (GO:0032981)2.51383419
163NADH dehydrogenase complex assembly (GO:0010257)2.51383419
164mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.51383419
165microtubule severing (GO:0051013)2.50067562
166regulation of collateral sprouting (GO:0048670)2.48648621
167cAMP catabolic process (GO:0006198)2.48638342
168anterior/posterior axis specification (GO:0009948)2.47140998
169head development (GO:0060322)2.46678261
170glutamate receptor signaling pathway (GO:0007215)2.44800842
171protein complex biogenesis (GO:0070271)2.44631392
172sulfation (GO:0051923)2.43517191
173determination of bilateral symmetry (GO:0009855)2.43298202
174limb development (GO:0060173)2.43255686
175appendage development (GO:0048736)2.43255686
176synaptic transmission, cholinergic (GO:0007271)2.43251288
177left/right axis specification (GO:0070986)2.42501773
178positive regulation of defense response to virus by host (GO:0002230)2.41928479
179RNA localization (GO:0006403)2.41307164
180signal transduction involved in regulation of gene expression (GO:0023019)2.40649408
181transcription from RNA polymerase I promoter (GO:0006360)2.40611478
182somite development (GO:0061053)2.38588929
183tryptophan catabolic process (GO:0006569)2.37667224
184indole-containing compound catabolic process (GO:0042436)2.37667224
185indolalkylamine catabolic process (GO:0046218)2.37667224
186negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36494889
187startle response (GO:0001964)2.36458109
188specification of symmetry (GO:0009799)2.36403048
189synapse assembly (GO:0007416)2.35563595
190respiratory chain complex IV assembly (GO:0008535)2.34753098
191doxorubicin metabolic process (GO:0044598)10.6766263
192daunorubicin metabolic process (GO:0044597)10.6766263
193polyketide metabolic process (GO:0030638)10.6766263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.15080193
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.75099853
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.75099853
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.75099853
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.84434009
6EZH2_22144423_ChIP-Seq_EOC_Human3.69128996
7ZNF274_21170338_ChIP-Seq_K562_Hela3.34611490
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.33308003
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.65774979
10IRF1_19129219_ChIP-ChIP_H3396_Human2.46195403
11IGF1R_20145208_ChIP-Seq_DFB_Human2.46047327
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45386283
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.38188340
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34887041
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24642512
16FUS_26573619_Chip-Seq_HEK293_Human2.20990767
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20696478
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.18587109
19NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.18309550
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.14972851
21P300_19829295_ChIP-Seq_ESCs_Human2.14066914
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01942192
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01205135
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99342236
25EWS_26573619_Chip-Seq_HEK293_Human1.99272166
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.98234177
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95925674
28TCF3_18692474_ChIP-Seq_MESCs_Mouse1.94017147
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.93523021
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92700649
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92362508
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.89492112
33TAF15_26573619_Chip-Seq_HEK293_Human1.88615618
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86950746
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84545119
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81182876
37RNF2_27304074_Chip-Seq_NSC_Mouse1.80987035
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.80438641
39SMAD4_21799915_ChIP-Seq_A2780_Human1.79349464
40ER_23166858_ChIP-Seq_MCF-7_Human1.75870870
41* STAT3_23295773_ChIP-Seq_U87_Human1.72100243
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.70825796
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70662153
44VDR_22108803_ChIP-Seq_LS180_Human1.68682288
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.67730931
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66722083
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64912336
48TCF4_23295773_ChIP-Seq_U87_Human1.62422234
49REST_21632747_ChIP-Seq_MESCs_Mouse1.60839899
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60563845
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60178478
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.57720059
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57277333
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52975092
55AR_21572438_ChIP-Seq_LNCaP_Human1.51362959
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51070216
57CBP_20019798_ChIP-Seq_JUKART_Human1.51070216
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50447452
59BCAT_22108803_ChIP-Seq_LS180_Human1.48921827
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46068516
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44989357
62AR_25329375_ChIP-Seq_VCAP_Human1.43739430
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40626551
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39187738
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38248424
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.37163782
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35693009
68GBX2_23144817_ChIP-Seq_PC3_Human1.34657148
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34457632
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34404163
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.33295687
72RUNX2_22187159_ChIP-Seq_PCA_Human1.33158981
73TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.31823575
74DROSHA_22980978_ChIP-Seq_HELA_Human1.30808768
75TCF4_22108803_ChIP-Seq_LS180_Human1.29733745
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28718019
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28513197
78TP53_22573176_ChIP-Seq_HFKS_Human1.28310930
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.26842176
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.24451573
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24311806
82TP53_16413492_ChIP-PET_HCT116_Human1.23944020
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22676337
84NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.21382053
85E2F1_17053090_ChIP-ChIP_MCF-7_Human1.20628927
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.19714967
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19698712
88* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19076919
89JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16614067
90* NANOG_19829295_ChIP-Seq_ESCs_Human1.16575599
91* SOX2_19829295_ChIP-Seq_ESCs_Human1.16575599
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.16465889
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.15904942
94POU5F1_16518401_ChIP-PET_MESCs_Mouse1.15738272
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14435588
96ZFX_18555785_Chip-Seq_ESCs_Mouse1.14067475
97* NANOG_16153702_ChIP-ChIP_HESCs_Human1.13718815
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13011676
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12471183
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.11735708
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11469832
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.11391488
103SMAD1_18555785_Chip-Seq_ESCs_Mouse1.11209569
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10056659
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.09686110
106STAT3_18555785_ChIP-Seq_MESCs_Mouse1.09601668
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09560237
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09233950
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09186819
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08357072
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07480647
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07388704
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07313030
114RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06169771
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.06163071
116PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05585118
117KLF4_18555785_Chip-Seq_ESCs_Mouse1.05393343
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05361784
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05357732
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.05279869
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05159321
122NANOG_18692474_ChIP-Seq_MESCs_Mouse1.04852317
123SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04288697
124FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04109113
125FOXA1_25329375_ChIP-Seq_VCAP_Human1.04109113
126EED_16625203_ChIP-ChIP_MESCs_Mouse1.03855771
127SALL1_21062744_ChIP-ChIP_HESCs_Human1.03636398
128E2F1_18555785_Chip-Seq_ESCs_Mouse1.03406938
129CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03339322
130EZH2_27294783_Chip-Seq_NPCs_Mouse1.01639809
131REST_18959480_ChIP-ChIP_MESCs_Mouse1.01308696
132EZH2_27294783_Chip-Seq_ESCs_Mouse1.01227307
133CDX2_20551321_ChIP-Seq_CACO-2_Human1.00863336
134EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00863003
135RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00863003
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00802766
137HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99922001
138ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99780749
139SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99529945
140NANOG_16518401_ChIP-PET_MESCs_Mouse0.99137590
141YY1_21170310_ChIP-Seq_MESCs_Mouse0.98657865
142OCT4_18555785_Chip-Seq_ESCs_Mouse0.98133961
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.97848188
144MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97537541
145STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97398042
146NCOR_22424771_ChIP-Seq_293T_Human0.97263003
147SMAD3_21741376_ChIP-Seq_ESCs_Human0.97028447
148MYC_18940864_ChIP-ChIP_HL60_Human0.96986787
149SOX2_18555785_Chip-Seq_ESCs_Mouse0.96802359
150NFE2_27457419_Chip-Seq_LIVER_Mouse0.96752035
151EZH2_27304074_Chip-Seq_ESCs_Mouse0.94164533
152P300_18555785_Chip-Seq_ESCs_Mouse0.93270106
153E2F7_22180533_ChIP-Seq_HELA_Human0.91860117
154CTCF_18555785_Chip-Seq_ESCs_Mouse0.90404819
155TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90117477
156SMAD3_21741376_ChIP-Seq_HESCs_Human0.88895631
157ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87935356
158RING1B_27294783_Chip-Seq_NPCs_Mouse0.87478213
159TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86624430
160CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86568096
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85782103
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85782103
163SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.85587291
164ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85545909
165TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85405781
166EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85181899
167NANOG_18555785_Chip-Seq_ESCs_Mouse0.85087524
168RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82686667
169RNF2_27304074_Chip-Seq_ESCs_Mouse0.82570255
170NANOG_18692474_ChIP-Seq_MEFs_Mouse0.81873741
171SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.81241502
172TP53_20018659_ChIP-ChIP_R1E_Mouse0.80941727
173SRF_21415370_ChIP-Seq_HL-1_Mouse0.80754302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation6.58342939
2MP0006292_abnormal_olfactory_placode5.16791867
3MP0005075_abnormal_melanosome_morpholog3.37986520
4MP0004264_abnormal_extraembryonic_tissu3.10251652
5MP0005499_abnormal_olfactory_system2.92558588
6MP0005394_taste/olfaction_phenotype2.92558588
7MP0003136_yellow_coat_color2.89522969
8MP0003122_maternal_imprinting2.69484161
9MP0004147_increased_porphyrin_level2.61736129
10MP0008877_abnormal_DNA_methylation2.52354930
11MP0003195_calcinosis2.50101692
12MP0002102_abnormal_ear_morphology2.38193375
13MP0002254_reproductive_system_inflammat2.37206205
14MP0001984_abnormal_olfaction2.35917035
15MP0005167_abnormal_blood-brain_barrier2.33690917
16MP0001968_abnormal_touch/_nociception2.24960800
17MP0000566_synostosis2.21404626
18MP0003938_abnormal_ear_development2.10242118
19MP0002735_abnormal_chemical_nociception2.09665153
20MP0002653_abnormal_ependyma_morphology2.07196143
21MP0003121_genomic_imprinting2.04299241
22MP0003880_abnormal_central_pattern2.03975489
23MP0004858_abnormal_nervous_system2.02765646
24MP0000569_abnormal_digit_pigmentation2.00809140
25MP0009745_abnormal_behavioral_response1.96823208
26MP0002277_abnormal_respiratory_mucosa1.96768512
27MP0002272_abnormal_nervous_system1.94185050
28MP0009046_muscle_twitch1.93445808
29MP0008057_abnormal_DNA_replication1.91336924
30MP0006276_abnormal_autonomic_nervous1.88720822
31MP0003890_abnormal_embryonic-extraembry1.87911312
32MP0004381_abnormal_hair_follicle1.85341033
33MP0000049_abnormal_middle_ear1.81959737
34MP0002736_abnormal_nociception_after1.79769471
35MP0005377_hearing/vestibular/ear_phenot1.74595937
36MP0003878_abnormal_ear_physiology1.74595937
37MP0002638_abnormal_pupillary_reflex1.67599880
38MP0010386_abnormal_urinary_bladder1.66726211
39MP0002734_abnormal_mechanical_nocicepti1.63792954
40MP0003646_muscle_fatigue1.61809235
41MP0003787_abnormal_imprinting1.60222891
42MP0005257_abnormal_intraocular_pressure1.58522448
43MP0000427_abnormal_hair_cycle1.58485057
44MP0001485_abnormal_pinna_reflex1.57411611
45MP0008789_abnormal_olfactory_epithelium1.57027888
46MP0001293_anophthalmia1.55845735
47MP0002332_abnormal_exercise_endurance1.54070792
48MP0003690_abnormal_glial_cell1.54007113
49MP0004885_abnormal_endolymph1.52814378
50MP0005171_absent_coat_pigmentation1.52682256
51MP0000678_abnormal_parathyroid_gland1.51193030
52MP0002572_abnormal_emotion/affect_behav1.50758110
53MP0008872_abnormal_physiological_respon1.49566738
54MP0001970_abnormal_pain_threshold1.48287708
55MP0002064_seizures1.47654945
56MP0004742_abnormal_vestibular_system1.47507764
57MP0001986_abnormal_taste_sensitivity1.45885000
58MP0003635_abnormal_synaptic_transmissio1.45503985
59MP0001501_abnormal_sleep_pattern1.42559506
60MP0002132_abnormal_respiratory_system1.39948644
61MP0002233_abnormal_nose_morphology1.38202794
62MP0003123_paternal_imprinting1.37916871
63MP0002837_dystrophic_cardiac_calcinosis1.34256453
64MP0006072_abnormal_retinal_apoptosis1.31458236
65MP0002063_abnormal_learning/memory/cond1.31120861
66MP0001188_hyperpigmentation1.30461691
67MP0002067_abnormal_sensory_capabilities1.27858735
68MP0002557_abnormal_social/conspecific_i1.26904608
69MP0005253_abnormal_eye_physiology1.26789184
70MP0000762_abnormal_tongue_morphology1.23737878
71MP0005386_behavior/neurological_phenoty1.21738443
72MP0004924_abnormal_behavior1.21738443
73MP0002234_abnormal_pharynx_morphology1.21099698
74MP0002160_abnormal_reproductive_system1.20759845
75MP0002733_abnormal_thermal_nociception1.19280236
76MP0004019_abnormal_vitamin_homeostasis1.18091369
77MP0006082_CNS_inflammation1.18038550
78MP0003786_premature_aging1.17894401
79MP0000372_irregular_coat_pigmentation1.17218889
80MP0002249_abnormal_larynx_morphology1.16684266
81MP0003186_abnormal_redox_activity1.16639771
82MP0001502_abnormal_circadian_rhythm1.14618039
83MP0002127_abnormal_cardiovascular_syste1.14454635
84MP0005646_abnormal_pituitary_gland1.14045639
85MP0008875_abnormal_xenobiotic_pharmacok1.11319819
86MP0010030_abnormal_orbit_morphology1.10883623
87MP0000778_abnormal_nervous_system1.09915686
88MP0004133_heterotaxia1.08247149
89MP0002938_white_spotting1.06668768
90MP0004782_abnormal_surfactant_physiolog1.05882762
91MP0004142_abnormal_muscle_tone1.05454886
92MP0005174_abnormal_tail_pigmentation1.05023806
93MP0005508_abnormal_skeleton_morphology1.04437517
94MP0002163_abnormal_gland_morphology1.04266626
95MP0003755_abnormal_palate_morphology1.03538360
96MP0002928_abnormal_bile_duct1.03377514
97MP0003718_maternal_effect1.02630580
98MP0005645_abnormal_hypothalamus_physiol1.02314071
99MP0005389_reproductive_system_phenotype1.01256904
100MP0004215_abnormal_myocardial_fiber1.01018527
101MP0005248_abnormal_Harderian_gland1.00464052
102MP0001440_abnormal_grooming_behavior1.00349002
103MP0000432_abnormal_head_morphology1.00347092
104MP0002116_abnormal_craniofacial_bone0.99798046
105MP0003183_abnormal_peptide_metabolism0.99534497
106MP0001963_abnormal_hearing_physiology0.99511875
107MP0009250_abnormal_appendicular_skeleto0.99066567
108MP0005391_vision/eye_phenotype0.99052902
109MP0008004_abnormal_stomach_pH0.99024985
110MP0003137_abnormal_impulse_conducting0.98211311
111MP0005195_abnormal_posterior_eye0.98037248
112MP0003937_abnormal_limbs/digits/tail_de0.97812628
113MP0001486_abnormal_startle_reflex0.97149268
114MP0006035_abnormal_mitochondrial_morpho0.97100115
115MP0003941_abnormal_skin_development0.94430740
116MP0000631_abnormal_neuroendocrine_gland0.92079710
117MP0004085_abnormal_heartbeat0.91448329
118MP0000026_abnormal_inner_ear0.90400089
119MP0001324_abnormal_eye_pigmentation0.90190059
120MP0005410_abnormal_fertilization0.90092379
121MP0002184_abnormal_innervation0.89163731
122MP0000428_abnormal_craniofacial_morphol0.89081056
123MP0002229_neurodegeneration0.88877643
124MP0002932_abnormal_joint_morphology0.88853135
125MP0002095_abnormal_skin_pigmentation0.88204964
126MP0008058_abnormal_DNA_repair0.87710529
127MP0001286_abnormal_eye_development0.87488288
128MP0003698_abnormal_male_reproductive0.87424245
129MP0002114_abnormal_axial_skeleton0.86433117
130MP0005187_abnormal_penis_morphology0.85228919
131MP0004270_analgesia0.84499853
132MP0008775_abnormal_heart_ventricle0.83669149
133MP0003283_abnormal_digestive_organ0.83365320
134MP0002882_abnormal_neuron_morphology0.83317253
135MP0001929_abnormal_gametogenesis0.83208140
136MP0002751_abnormal_autonomic_nervous0.82084672
137MP0004145_abnormal_muscle_electrophysio0.81212091
138MP0003935_abnormal_craniofacial_develop0.79879477
139MP0004043_abnormal_pH_regulation0.79773415
140MP0001958_emphysema0.79249550
141MP0002752_abnormal_somatic_nervous0.78900289
142MP0004957_abnormal_blastocyst_morpholog0.78849292
143MP0000647_abnormal_sebaceous_gland0.76484072
144MP0000015_abnormal_ear_pigmentation0.75184198
145MP0005551_abnormal_eye_electrophysiolog0.74277639
146MP0004883_abnormal_blood_vessel0.73944496
147MP0002109_abnormal_limb_morphology0.70356283
148MP0003315_abnormal_perineum_morphology0.70136792
149MP0002092_abnormal_eye_morphology0.69934968
150MP0000163_abnormal_cartilage_morphology0.68778551
151MP0001270_distended_abdomen0.68711057
152MP0004272_abnormal_basement_membrane0.68582696
153MP0008932_abnormal_embryonic_tissue0.67951361
154MP0000955_abnormal_spinal_cord0.67753622
155MP0005379_endocrine/exocrine_gland_phen0.67434667
156MP0001905_abnormal_dopamine_level0.65619097
157MP0000920_abnormal_myelination0.65369160
158MP0002098_abnormal_vibrissa_morphology0.64818419
159MP0001915_intracranial_hemorrhage0.60256383
160MP0002876_abnormal_thyroid_physiology0.59673890
161MP0000383_abnormal_hair_follicle0.59547899
162MP0001672_abnormal_embryogenesis/_devel0.58918517
163MP0005380_embryogenesis_phenotype0.58918517
164MP0003111_abnormal_nucleus_morphology0.58104817

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.26381573
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.10789147
3Molar tooth sign on MRI (HP:0002419)4.55560700
4Abnormality of midbrain morphology (HP:0002418)4.55560700
5Pancreatic cysts (HP:0001737)4.51368436
6Chromsome breakage (HP:0040012)4.22655308
7Pancreatic fibrosis (HP:0100732)4.21756262
8Nephronophthisis (HP:0000090)4.21464134
9Hepatoblastoma (HP:0002884)4.19285067
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.94001823
11Absent/shortened dynein arms (HP:0200106)3.94001823
12Type II lissencephaly (HP:0007260)3.93287773
13Abnormal respiratory motile cilium morphology (HP:0005938)3.87418804
14Abnormal respiratory epithelium morphology (HP:0012253)3.87418804
15Nephroblastoma (Wilms tumor) (HP:0002667)3.86717372
16True hermaphroditism (HP:0010459)3.84541851
17Birth length less than 3rd percentile (HP:0003561)3.73891728
18Aplasia/Hypoplasia of the fovea (HP:0008060)3.65160482
19Hypoplasia of the fovea (HP:0007750)3.65160482
20Embryonal renal neoplasm (HP:0011794)3.58907773
21Abnormality of the fovea (HP:0000493)3.58650975
22Abnormal respiratory motile cilium physiology (HP:0012261)3.58277135
23Medial flaring of the eyebrow (HP:0010747)3.56957151
24Abnormality of the renal medulla (HP:0100957)3.55379226
25Congenital stationary night blindness (HP:0007642)3.43281236
26Abnormal lung lobation (HP:0002101)3.41389626
27Rib fusion (HP:0000902)3.21469215
28Hypochromic microcytic anemia (HP:0004840)3.20428370
29Nasolacrimal duct obstruction (HP:0000579)3.15799641
30Anomalous pulmonary venous return (HP:0010772)3.11605348
31Gait imbalance (HP:0002141)3.08667308
32Cystic liver disease (HP:0006706)3.07850704
33Rectovaginal fistula (HP:0000143)3.07724154
34Rectal fistula (HP:0100590)3.07724154
35Attenuation of retinal blood vessels (HP:0007843)3.05266286
36Partial duplication of thumb phalanx (HP:0009944)2.98352838
37Congenital primary aphakia (HP:0007707)2.95603640
38Meckel diverticulum (HP:0002245)2.91968512
39Rhinitis (HP:0012384)2.89235732
40Microvesicular hepatic steatosis (HP:0001414)2.88628506
41Type I transferrin isoform profile (HP:0003642)2.85863631
42Abnormality of the renal cortex (HP:0011035)2.82613103
43Nephrogenic diabetes insipidus (HP:0009806)2.76331839
44Abnormality of the ileum (HP:0001549)2.75306592
45Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.72020632
46Intestinal fistula (HP:0100819)2.70748746
47Lissencephaly (HP:0001339)2.69664928
48Testicular atrophy (HP:0000029)2.67819013
49Osteomalacia (HP:0002749)2.67219429
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.66049978
51Reduced antithrombin III activity (HP:0001976)2.63926590
52Genital tract atresia (HP:0001827)2.60915692
53Cerebellar dysplasia (HP:0007033)2.60513441
54Abnormality of the pulmonary veins (HP:0011718)2.58759374
553-Methylglutaconic aciduria (HP:0003535)2.58442627
56Inability to walk (HP:0002540)2.57868002
57Vaginal atresia (HP:0000148)2.57107944
58Tubular atrophy (HP:0000092)2.54447856
59Abnormality of the lacrimal duct (HP:0011481)2.52961749
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.46195406
61Decreased central vision (HP:0007663)2.46058565
62Septo-optic dysplasia (HP:0100842)2.45781975
63Supernumerary spleens (HP:0009799)2.45597334
64Vaginal fistula (HP:0004320)2.42169200
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.41603875
66Duodenal stenosis (HP:0100867)2.41352115
67Small intestinal stenosis (HP:0012848)2.41352115
68Duplication of thumb phalanx (HP:0009942)2.39470259
69Poor coordination (HP:0002370)2.37609970
70Absent speech (HP:0001344)2.37329855
71Gaze-evoked nystagmus (HP:0000640)2.37030891
72Partial duplication of the phalanx of hand (HP:0009999)2.34419812
73Anencephaly (HP:0002323)2.32847543
74Congenital hepatic fibrosis (HP:0002612)2.32638712
75Ectopic kidney (HP:0000086)2.31960265
76Patellar aplasia (HP:0006443)2.31496980
77Increased CSF protein (HP:0002922)2.30369595
78Bifid tongue (HP:0010297)2.29789000
79Hypergonadotropic hypogonadism (HP:0000815)2.29338048
80Progressive cerebellar ataxia (HP:0002073)2.28287311
81Impulsivity (HP:0100710)2.26942372
82Febrile seizures (HP:0002373)2.25125595
83Irregular epiphyses (HP:0010582)2.24838341
84Occipital encephalocele (HP:0002085)2.24406719
85Widely spaced teeth (HP:0000687)2.24063979
86Facial cleft (HP:0002006)2.21679558
87Abnormality of the phalanges of the hallux (HP:0010057)2.21434147
88Postaxial foot polydactyly (HP:0001830)2.20313852
89Hemiparesis (HP:0001269)2.19344775
90Sclerocornea (HP:0000647)2.18332366
91Polydipsia (HP:0001959)2.18194706
92Abnormal drinking behavior (HP:0030082)2.18194706
93Furrowed tongue (HP:0000221)2.16376751
94Aplasia/Hypoplasia of the patella (HP:0006498)2.15342400
95Broad-based gait (HP:0002136)2.15258086
96Hyperventilation (HP:0002883)2.14305817
97Abnormal rod and cone electroretinograms (HP:0008323)2.13651115
98Abnormality of the nasolacrimal system (HP:0000614)2.13514244
99Large for gestational age (HP:0001520)2.11614869
100Horizontal nystagmus (HP:0000666)2.10996822
101Fused cervical vertebrae (HP:0002949)2.08466082
102Bony spicule pigmentary retinopathy (HP:0007737)2.07802266
103Preauricular pit (HP:0004467)2.07597409
104Periauricular skin pits (HP:0100277)2.07597409
105Protruding tongue (HP:0010808)2.07136906
106Abnormality of liposaccharide metabolism (HP:0010968)2.06459084
107Abnormality of glycosphingolipid metabolism (HP:0004343)2.06459084
108Abnormality of glycolipid metabolism (HP:0010969)2.06459084
109Embryonal neoplasm (HP:0002898)2.05501181
110Retinal dysplasia (HP:0007973)2.04494121
111Increased corneal curvature (HP:0100692)2.03773195
112Keratoconus (HP:0000563)2.03773195
113Duplicated collecting system (HP:0000081)2.02843351
114Aplasia/hypoplasia of the uterus (HP:0008684)2.02729254
115Abolished electroretinogram (ERG) (HP:0000550)2.02639161
116Postaxial hand polydactyly (HP:0001162)2.01890344
117Abnormality of molar (HP:0011077)2.01572389
118Abnormality of molar morphology (HP:0011070)2.01572389
119Abnormality of the dental root (HP:0006486)1.98582914
120Taurodontia (HP:0000679)1.98582914
121Abnormality of permanent molar morphology (HP:0011071)1.98582914
122Bronchiectasis (HP:0002110)1.98169926
123Short middle phalanx of the 5th finger (HP:0004220)1.98131493
124Flat capital femoral epiphysis (HP:0003370)1.97747646
125Hypoplasia of the uterus (HP:0000013)1.97693773
126Aplasia/Hypoplasia of the macula (HP:0008059)1.95872058
127Abnormality of the labia minora (HP:0012880)1.94798038
128Aplasia/hypoplasia of the humerus (HP:0006507)1.94742198
129Upper limb muscle weakness (HP:0003484)1.94347712
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.92963676
131Optic nerve hypoplasia (HP:0000609)1.92335077
132Recurrent corneal erosions (HP:0000495)1.92285592
133Abnormality of the preputium (HP:0100587)1.92232975
134Abnormal ciliary motility (HP:0012262)1.91874781
135Abnormality of the duodenum (HP:0002246)1.91305116
136Abnormality of the renal collecting system (HP:0004742)1.91078907
137Progressive inability to walk (HP:0002505)1.90872753
138Polyuria (HP:0000103)1.90487295
139Progressive external ophthalmoplegia (HP:0000590)1.90188875
140Sparse eyelashes (HP:0000653)1.89332857
141Chronic hepatic failure (HP:0100626)1.89167557
142Abnormality of the pons (HP:0007361)1.88876957
143Pendular nystagmus (HP:0012043)1.86849807
144Carpal bone hypoplasia (HP:0001498)1.85699294
145Abnormality of the pubic bones (HP:0003172)1.85663108
146Prominent nasal bridge (HP:0000426)1.85605791
147Renal duplication (HP:0000075)1.85573250
148Ectopic anus (HP:0004397)1.85357695
149Drooling (HP:0002307)1.83793445
150Aplasia/Hypoplasia of the spleen (HP:0010451)1.82711146
151Hypoplastic labia majora (HP:0000059)1.82319166
152Male pseudohermaphroditism (HP:0000037)1.81919262
153Preaxial hand polydactyly (HP:0001177)1.81480289
154Chorioretinal atrophy (HP:0000533)1.81146926
155Abnormal biliary tract physiology (HP:0012439)1.80772505
156Bile duct proliferation (HP:0001408)1.80772505
157Decreased circulating renin level (HP:0003351)1.80534621
158Hypoplasia of the pons (HP:0012110)1.79883072
159Breast hypoplasia (HP:0003187)1.79557557
160Abnormality of the dental pulp (HP:0006479)1.78062681
161Oculomotor apraxia (HP:0000657)1.77318824
162Myokymia (HP:0002411)1.77295020
163Anterior segment dysgenesis (HP:0007700)1.76695203
164Narrow forehead (HP:0000341)1.76460318
165Short humerus (HP:0005792)1.75284702
166Concave nail (HP:0001598)1.74030371
167Abnormality of the labia majora (HP:0012881)1.73341977
168Abnormality of the distal phalanx of the thumb (HP:0009617)1.72807110
169Highly arched eyebrow (HP:0002553)1.72458390
170Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.72231157
171Dyschromatopsia (HP:0007641)1.71640365
172Dandy-Walker malformation (HP:0001305)1.71179744
173Hypoplastic scapulae (HP:0000882)1.70592102
174Aplasia/Hypoplasia of the scapulae (HP:0006713)1.70592102
175Oligodactyly (hands) (HP:0001180)1.70421831
176Abnormality of renal resorption (HP:0011038)1.70134940
177Aplasia/Hypoplasia of the sternum (HP:0006714)1.69826919
178Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.69546686
179Mesomelia (HP:0003027)1.66747740
180Atonic seizures (HP:0010819)1.66440282
181Aplasia/Hypoplasia of the lens (HP:0008063)1.65262977
182Focal seizures (HP:0007359)1.64856449
183Epileptic encephalopathy (HP:0200134)1.63274060
184Severe muscular hypotonia (HP:0006829)1.61951604
185Intestinal atresia (HP:0011100)1.61820471
186Excessive salivation (HP:0003781)1.61546182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.58902750
2FRK5.17394976
3GRK54.31237653
4ADRBK23.98827059
5ACVR1B3.93250760
6BMPR1B3.76405123
7GRK13.64282303
8CASK3.03225925
9DAPK22.57695294
10IRAK32.56215186
11GRK72.53220401
12GRK62.49260548
13WNK32.32408924
14ZAK2.30416319
15AKT32.27408086
16TTK2.24346993
17INSRR2.22933228
18CSF1R2.10072638
19MAPK72.09177720
20WNK12.09047990
21PLK41.98776208
22WNK41.98105785
23MAP3K41.82653064
24TGFBR21.78089743
25EIF2AK21.76209798
26MAPK151.71174652
27STK38L1.67745425
28FGFR21.57488081
29OXSR11.56425162
30EPHA41.54794388
31PNCK1.52231795
32TLK11.49929295
33TGFBR11.47461814
34STK101.46819814
35NEK61.39618681
36MATK1.37395047
37PRPF4B1.36290342
38PTK2B1.33604449
39SRPK11.32464675
40NUAK11.30220190
41TNIK1.29560222
42IRAK41.28764820
43CAMK41.25459361
44MAP4K21.24212890
45TRIM281.20239899
46MOS1.17894865
47CAMKK21.17537881
48ADRBK11.13381046
49YES11.06821653
50PRKG21.06183354
51PAK31.06021169
52VRK11.05399784
53CHEK21.04766550
54PLK11.02527108
55BMPR21.02095058
56CAMK2B0.99844168
57TAOK30.99589406
58CAMKK10.98498620
59PIK3CA0.98079957
60CDK70.97331658
61NME10.96487630
62TIE10.96068081
63TXK0.93817275
64CAMK1G0.92805272
65TYRO30.91987278
66MKNK20.90912998
67SIK30.90589268
68SIK20.89396223
69BUB10.83402051
70IRAK20.82725315
71MAP2K40.81136414
72CCNB10.80442693
73MAP2K70.80044357
74CAMK10.78097441
75CAMK2D0.77002247
76PBK0.75892363
77STK240.75207940
78CAMK1D0.75058160
79ROCK20.74860784
80MAP3K70.74075886
81ERN10.73970237
82EPHA20.72069875
83CAMK2G0.70638437
84BLK0.70262679
85EPHA30.69267351
86PHKG20.68777659
87PHKG10.68777659
88MAP3K140.68069246
89NTRK20.67039273
90STK110.66003445
91PLK20.65772422
92NLK0.64387183
93EIF2AK30.63736350
94TNK20.63446002
95NTRK30.62788284
96NTRK10.62523545
97PRKCI0.62265337
98PRKCQ0.61586519
99NEK20.60390606
100IKBKB0.60120559
101MST40.59954114
102PRKCZ0.58856088
103OBSCN0.57482717
104MUSK0.56605684
105STK160.54540290
106AKT20.54333359
107PINK10.53023770
108CSNK1G20.52918515
109BCKDK0.52463111
110CSNK1G10.51188753
111PDK20.51177598
112PRKCG0.49959170
113MAPK130.49891531
114IRAK10.47711390
115SGK20.47335020
116MKNK10.47299744
117MARK10.46998708
118MARK20.46822763
119PLK30.46610981
120TAOK20.46524347
121STK30.45950849
122PAK40.45804072
123CDK30.45539785
124PRKG10.45214514
125PRKCD0.43536208
126DYRK20.41660377
127MELK0.41338498
128MAPKAPK30.39843753
129CLK10.39834923
130ERBB30.39515741
131PRKAA20.38212698
132MAP2K60.37736488
133DYRK1A0.37710725
134ROCK10.36631719
135CSNK1D0.36530066
136IGF1R0.36304508
137PRKCH0.35954809
138BRD40.35624167
139LMTK20.34563874
140DDR20.34378693
141PKN10.34149756
142STK390.33535877
143SGK2230.33286519
144SGK4940.33286519
145RPS6KA50.33155261
146MAPK120.33116362
147CSNK1A1L0.32900001
148CSNK1A10.32326075
149CSNK1G30.31951154
150SGK10.31926114
151PRKACA0.31768600
152CHEK10.31760127
153PRKAA10.31497200
154LATS10.31234345
155PRKCE0.30256442
156MAP2K10.30017331
157CAMK2A0.29840476
158PRKACB0.29822847
159BCR0.28911284

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.37482316
2Vitamin B6 metabolism_Homo sapiens_hsa007504.68451760
3Arachidonic acid metabolism_Homo sapiens_hsa005903.24524961
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90093257
5Fanconi anemia pathway_Homo sapiens_hsa034602.66971061
6Butanoate metabolism_Homo sapiens_hsa006502.52852399
7Nitrogen metabolism_Homo sapiens_hsa009102.33224687
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29846144
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.25305688
10RNA polymerase_Homo sapiens_hsa030202.11636264
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.02110942
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00975117
13Linoleic acid metabolism_Homo sapiens_hsa005911.98259655
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.98102068
15Homologous recombination_Homo sapiens_hsa034401.94269813
16Ether lipid metabolism_Homo sapiens_hsa005651.92157369
17ABC transporters_Homo sapiens_hsa020101.87109572
18Fructose and mannose metabolism_Homo sapiens_hsa000511.76846867
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60466187
20Other glycan degradation_Homo sapiens_hsa005111.60237038
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54112317
22Olfactory transduction_Homo sapiens_hsa047401.51713456
23Propanoate metabolism_Homo sapiens_hsa006401.49544527
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49418961
25Tryptophan metabolism_Homo sapiens_hsa003801.47038857
26Circadian entrainment_Homo sapiens_hsa047131.45545155
27Insulin secretion_Homo sapiens_hsa049111.42474077
28Selenocompound metabolism_Homo sapiens_hsa004501.40798406
29Nicotine addiction_Homo sapiens_hsa050331.40224498
30Basal transcription factors_Homo sapiens_hsa030221.38574296
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33976032
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31937127
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31644681
34Vitamin digestion and absorption_Homo sapiens_hsa049771.29748519
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28797652
36beta-Alanine metabolism_Homo sapiens_hsa004101.26068168
37Graft-versus-host disease_Homo sapiens_hsa053321.23755718
38Basal cell carcinoma_Homo sapiens_hsa052171.20859959
39Ovarian steroidogenesis_Homo sapiens_hsa049131.20773526
40Galactose metabolism_Homo sapiens_hsa000521.18037043
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17841364
42Parkinsons disease_Homo sapiens_hsa050121.14610707
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.14276101
44DNA replication_Homo sapiens_hsa030301.14152458
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13200348
46Base excision repair_Homo sapiens_hsa034101.12347779
47Sphingolipid metabolism_Homo sapiens_hsa006001.09990293
48Taste transduction_Homo sapiens_hsa047421.09762331
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08888904
50Autoimmune thyroid disease_Homo sapiens_hsa053201.07947931
51Serotonergic synapse_Homo sapiens_hsa047261.07558399
52Histidine metabolism_Homo sapiens_hsa003401.05326300
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04853832
54Circadian rhythm_Homo sapiens_hsa047101.04336784
55Mismatch repair_Homo sapiens_hsa034301.02707133
56Pyrimidine metabolism_Homo sapiens_hsa002401.01610444
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01488997
58Retinol metabolism_Homo sapiens_hsa008301.00228082
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00081605
60Regulation of autophagy_Homo sapiens_hsa041400.99422835
61Cardiac muscle contraction_Homo sapiens_hsa042600.98145756
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97701021
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.97184691
64Peroxisome_Homo sapiens_hsa041460.96645324
65RNA degradation_Homo sapiens_hsa030180.96545795
66Salivary secretion_Homo sapiens_hsa049700.96185002
67Inositol phosphate metabolism_Homo sapiens_hsa005620.96095616
68Dorso-ventral axis formation_Homo sapiens_hsa043200.93350056
69Collecting duct acid secretion_Homo sapiens_hsa049660.92931343
70Caffeine metabolism_Homo sapiens_hsa002320.92818670
71Glutamatergic synapse_Homo sapiens_hsa047240.92787322
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.90478846
73Allograft rejection_Homo sapiens_hsa053300.88434396
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88256674
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87614437
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85900238
77Gastric acid secretion_Homo sapiens_hsa049710.85341144
78Dopaminergic synapse_Homo sapiens_hsa047280.83043146
79Hedgehog signaling pathway_Homo sapiens_hsa043400.82844084
80One carbon pool by folate_Homo sapiens_hsa006700.81967911
81Purine metabolism_Homo sapiens_hsa002300.81736646
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80391079
83Hippo signaling pathway_Homo sapiens_hsa043900.79026045
84GABAergic synapse_Homo sapiens_hsa047270.78879754
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.76167661
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75559902
87Spliceosome_Homo sapiens_hsa030400.74304715
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.74096436
89Cell cycle_Homo sapiens_hsa041100.74046135
90Nucleotide excision repair_Homo sapiens_hsa034200.71540281
91Glycerolipid metabolism_Homo sapiens_hsa005610.71530237
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.70756892
93Alzheimers disease_Homo sapiens_hsa050100.70637837
94Mineral absorption_Homo sapiens_hsa049780.70075305
95African trypanosomiasis_Homo sapiens_hsa051430.69636150
96Protein digestion and absorption_Homo sapiens_hsa049740.68796909
97ECM-receptor interaction_Homo sapiens_hsa045120.65215091
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64940875
99Cholinergic synapse_Homo sapiens_hsa047250.64747770
100Asthma_Homo sapiens_hsa053100.63186520
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61237156
102Amphetamine addiction_Homo sapiens_hsa050310.59970417
103RNA transport_Homo sapiens_hsa030130.59658692
104Non-homologous end-joining_Homo sapiens_hsa034500.59016295
105Wnt signaling pathway_Homo sapiens_hsa043100.58927250
106Oxytocin signaling pathway_Homo sapiens_hsa049210.58793986
107Bile secretion_Homo sapiens_hsa049760.57146943
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54873203
109Cocaine addiction_Homo sapiens_hsa050300.54408008
110Pathways in cancer_Homo sapiens_hsa052000.54356016
111Long-term depression_Homo sapiens_hsa047300.53618573
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53379476
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53369790
114Calcium signaling pathway_Homo sapiens_hsa040200.53178089
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52383449
116Proteasome_Homo sapiens_hsa030500.50467175
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50444157
118Axon guidance_Homo sapiens_hsa043600.49236680
119Synaptic vesicle cycle_Homo sapiens_hsa047210.48774337
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.48705329
121Hematopoietic cell lineage_Homo sapiens_hsa046400.44725984
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44607393
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44168950
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.43889306
125Huntingtons disease_Homo sapiens_hsa050160.43602534
126Lysine degradation_Homo sapiens_hsa003100.43519508
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43449238
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43340803
129Rheumatoid arthritis_Homo sapiens_hsa053230.43092677
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.42691202
131Fatty acid degradation_Homo sapiens_hsa000710.42327531
132Renin secretion_Homo sapiens_hsa049240.42269696
133mRNA surveillance pathway_Homo sapiens_hsa030150.41368402
134Malaria_Homo sapiens_hsa051440.40752198
135Metabolic pathways_Homo sapiens_hsa011000.40292975
136Pancreatic secretion_Homo sapiens_hsa049720.39888723
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39208330
138Morphine addiction_Homo sapiens_hsa050320.39184354
139Choline metabolism in cancer_Homo sapiens_hsa052310.38788134
140p53 signaling pathway_Homo sapiens_hsa041150.38649592
141Phototransduction_Homo sapiens_hsa047440.37367682
142Herpes simplex infection_Homo sapiens_hsa051680.36695627
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36469630
144Protein export_Homo sapiens_hsa030600.36349341
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36287255
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35901028
147Ras signaling pathway_Homo sapiens_hsa040140.35676228
148TGF-beta signaling pathway_Homo sapiens_hsa043500.34690574
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34567391
150Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34438176
151Chemical carcinogenesis_Homo sapiens_hsa052040.34302169
152Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34194183
153Oxidative phosphorylation_Homo sapiens_hsa001900.34141169
154cAMP signaling pathway_Homo sapiens_hsa040240.32759969
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.31821058

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