SLC12A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.26059608
2response to pheromone (GO:0019236)6.19081481
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.77806543
4positive regulation of gamma-delta T cell activation (GO:0046645)5.66566989
5antigen processing and presentation of endogenous antigen (GO:0019883)5.65308884
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.25156179
7detection of other organism (GO:0098543)5.01649112
8detection of bacterium (GO:0016045)4.91987708
9neutrophil activation involved in immune response (GO:0002283)4.91283788
10leukocyte aggregation (GO:0070486)4.70789004
11response to peptidoglycan (GO:0032494)4.52104202
12regulation of gamma-delta T cell activation (GO:0046643)4.31937948
13negative regulation of lymphocyte mediated immunity (GO:0002707)4.25854050
14detection of external biotic stimulus (GO:0098581)4.23413594
15cellular extravasation (GO:0045123)4.16935812
16negative regulation of interleukin-12 production (GO:0032695)4.14670338
17microglial cell activation (GO:0001774)4.05082671
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.02756898
19positive regulation by organism of defense response of other organism involved in symbiotic interact4.02756898
20modulation by symbiont of host immune response (GO:0052553)4.02756898
21positive regulation by symbiont of host defense response (GO:0052509)4.02756898
22modulation by symbiont of host defense response (GO:0052031)4.02756898
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.02756898
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.02436654
25neutrophil activation (GO:0042119)3.97957114
26detection of molecule of bacterial origin (GO:0032490)3.88200216
27leukocyte migration involved in inflammatory response (GO:0002523)3.88059454
28respiratory burst (GO:0045730)3.87798893
29response to interleukin-15 (GO:0070672)3.87646061
30regulation of gamma-delta T cell differentiation (GO:0045586)3.85058252
31macrophage activation involved in immune response (GO:0002281)3.84283005
32negative regulation of leukocyte mediated immunity (GO:0002704)3.83704563
33regulation of interferon-beta biosynthetic process (GO:0045357)3.75148571
34immunoglobulin mediated immune response (GO:0016064)3.73815086
35detection of biotic stimulus (GO:0009595)3.72473497
36negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.72029217
37regulation of mast cell degranulation (GO:0043304)3.69498148
38negative regulation of T cell mediated immunity (GO:0002710)3.58640029
39regulation of myeloid leukocyte mediated immunity (GO:0002886)3.58475468
40granulocyte activation (GO:0036230)3.58131306
41antigen processing and presentation via MHC class Ib (GO:0002475)3.56929651
42negative regulation of erythrocyte differentiation (GO:0045647)3.50456562
43cellular response to interleukin-15 (GO:0071350)3.48431951
44positive thymic T cell selection (GO:0045059)3.45932073
45positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.45403876
46B cell receptor signaling pathway (GO:0050853)3.42314902
47regulation of leukocyte degranulation (GO:0043300)3.40982353
48regulation of mast cell activation involved in immune response (GO:0033006)3.39326971
49response to type I interferon (GO:0034340)3.37069905
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.36935399
51germinal center formation (GO:0002467)3.34971852
52response to muramyl dipeptide (GO:0032495)3.34479894
53cellular response to type I interferon (GO:0071357)3.33159637
54type I interferon signaling pathway (GO:0060337)3.33159637
55negative regulation of phagocytosis (GO:0050765)3.30882616
56positive regulation of mast cell activation (GO:0033005)3.30334219
57production of molecular mediator involved in inflammatory response (GO:0002532)3.30111135
58negative thymic T cell selection (GO:0045060)3.27473045
59regulation of T cell tolerance induction (GO:0002664)3.27010682
60dicarboxylic acid biosynthetic process (GO:0043650)3.26494738
61regulation of B cell differentiation (GO:0045577)3.19230125
62L-amino acid import (GO:0043092)3.18717248
63regulation of mast cell activation (GO:0033003)3.18564475
64negative regulation of granulocyte differentiation (GO:0030853)3.18465052
65negative T cell selection (GO:0043383)3.16124580
66defense response to protozoan (GO:0042832)3.14722112
67regulation of T-helper 2 cell differentiation (GO:0045628)3.13513131
68regulation of T cell mediated cytotoxicity (GO:0001914)3.12672976
69T cell selection (GO:0045058)3.12579093
70regulation of tolerance induction (GO:0002643)3.10341867
71positive regulation of T cell mediated cytotoxicity (GO:0001916)3.09657708
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.09378267
73activated T cell proliferation (GO:0050798)3.08747783
74regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07051063
75negative regulation of T-helper cell differentiation (GO:0045623)3.05936099
76negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.05936099
77thymic T cell selection (GO:0045061)3.03706882
78regulation of regulated secretory pathway (GO:1903305)3.02448898
79alanine transport (GO:0032328)3.01779953
80mannose metabolic process (GO:0006013)3.01280455
81negative regulation of interleukin-6 production (GO:0032715)3.01166328
82leukocyte degranulation (GO:0043299)3.00875131
83positive regulation of Rap GTPase activity (GO:0032854)2.99474852
84regulation of natural killer cell mediated immunity (GO:0002715)2.98199050
85regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98199050
86negative regulation of innate immune response (GO:0045824)2.98144731
87tolerance induction (GO:0002507)2.97925495
88response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97456856
89response to host immune response (GO:0052572)2.97456856
90interferon-gamma-mediated signaling pathway (GO:0060333)2.97069343
91positive regulation of B cell differentiation (GO:0045579)2.96200197
92negative regulation of type 2 immune response (GO:0002829)2.94870609
93positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.93218817
94regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91390836
95positive T cell selection (GO:0043368)2.88936477
96synaptic vesicle maturation (GO:0016188)2.88583152
97positive regulation of mast cell degranulation (GO:0043306)2.87230604
98positive regulation of mast cell activation involved in immune response (GO:0033008)2.87230604
99locomotory exploration behavior (GO:0035641)2.80812107
100response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77695730
101response to host (GO:0075136)2.77695730
102response to host defenses (GO:0052200)2.77695730
103negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.76860947
104regulation of Rap GTPase activity (GO:0032317)2.72911266
105regulation of ARF GTPase activity (GO:0032312)2.71691327
106glycine transport (GO:0015816)2.69310732
107regulation of B cell receptor signaling pathway (GO:0050855)2.67662374
108adenosine receptor signaling pathway (GO:0001973)2.63072204
109I-kappaB phosphorylation (GO:0007252)2.62902634
110macrophage activation (GO:0042116)2.60867696
111regulation of ARF protein signal transduction (GO:0032012)2.57810468
112chondroitin sulfate catabolic process (GO:0030207)2.52922987
113membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.50970514
114positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.49785104
115amino acid import (GO:0043090)2.46680144
116positive regulation of toll-like receptor signaling pathway (GO:0034123)2.41785730
117positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.41520370
118sodium ion export (GO:0071436)2.39209544
119regulation of synapse structural plasticity (GO:0051823)2.39122150
120positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.36110053
121central nervous system myelination (GO:0022010)2.35947860
122axon ensheathment in central nervous system (GO:0032291)2.35947860
123adult walking behavior (GO:0007628)2.34548721
124response to auditory stimulus (GO:0010996)2.33129710
125glycosylceramide metabolic process (GO:0006677)2.32363057
126negative regulation of cell killing (GO:0031342)2.32088786
127negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.32088786
128regulation of granulocyte differentiation (GO:0030852)2.30595427
129regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.29744964
130alpha-linolenic acid metabolic process (GO:0036109)2.29394463
131clathrin coat assembly (GO:0048268)2.27711117
132regulation of short-term neuronal synaptic plasticity (GO:0048172)2.27488658
133glutamate secretion (GO:0014047)2.27088357
134lipoprotein transport (GO:0042953)2.26800692
135regulation of beta-amyloid formation (GO:1902003)2.26662649
136nerve growth factor signaling pathway (GO:0038180)2.24548694
137ionotropic glutamate receptor signaling pathway (GO:0035235)2.21354729
138triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.18852551
139positive regulation of cellular amide metabolic process (GO:0034250)2.18523509
140L-phenylalanine catabolic process (GO:0006559)2.18209476
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.18209476
142cellular potassium ion homeostasis (GO:0030007)2.18009065
143semaphorin-plexin signaling pathway (GO:0071526)2.15066949
144lysosome organization (GO:0007040)2.13517337
145lytic vacuole organization (GO:0080171)2.13517337
146glycosphingolipid catabolic process (GO:0046479)2.13291022
147glutamate metabolic process (GO:0006536)2.11733041
148positive regulation of antigen processing and presentation (GO:0002579)2.11317395
149regulation of extracellular matrix disassembly (GO:0010715)2.10358500
150cortical actin cytoskeleton organization (GO:0030866)2.09356379
151negative regulation of tissue remodeling (GO:0034104)2.07428159
152G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.07349631
153gamma-aminobutyric acid transport (GO:0015812)2.07196234
154stress granule assembly (GO:0034063)2.06827656
155potassium ion import (GO:0010107)2.06235913
156protein-lipid complex assembly (GO:0065005)2.06021242
157protein kinase C signaling (GO:0070528)2.04348526
158positive regulation of interferon-alpha production (GO:0032727)2.03799208
159myeloid cell activation involved in immune response (GO:0002275)2.01466217
160cellular modified amino acid catabolic process (GO:0042219)2.00472667
161fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.00079641
162neuromuscular process controlling balance (GO:0050885)1.99215207
163response to lipoprotein particle (GO:0055094)1.99032497
164low-density lipoprotein particle remodeling (GO:0034374)1.98563609
165peptidyl-tyrosine autophosphorylation (GO:0038083)1.97043046
166L-amino acid transport (GO:0015807)1.97026389
167positive regulation of chemokine secretion (GO:0090197)1.96914580
168Golgi to endosome transport (GO:0006895)1.96428864
169synaptic vesicle endocytosis (GO:0048488)1.96254868
170ovulation cycle (GO:0042698)1.95934616
171positive regulation of histone deacetylation (GO:0031065)1.94620862
172neutrophil mediated immunity (GO:0002446)1.93773320
173amyloid precursor protein catabolic process (GO:0042987)1.93655651
174N-glycan processing (GO:0006491)1.92812217
175regulation of acrosome reaction (GO:0060046)1.92139594
176L-alpha-amino acid transmembrane transport (GO:1902475)1.91555256
177regulation of cellular amide metabolic process (GO:0034248)1.90540289
178regulation of interferon-alpha production (GO:0032647)1.90308611

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.72368800
2MYC_22102868_ChIP-Seq_BL_Human2.67375279
3IKZF1_21737484_ChIP-ChIP_HCT116_Human2.58525643
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.50204894
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49711437
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42025343
7MAF_26560356_Chip-Seq_TH1_Human2.34919613
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.28137289
9* SPI1_23547873_ChIP-Seq_NB4_Human2.24081452
10DROSHA_22980978_ChIP-Seq_HELA_Human2.22325957
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.21106068
12RUNX1_22412390_ChIP-Seq_EML_Mouse2.20106817
13UTX_26944678_Chip-Seq_JUKART_Human2.15047906
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14009671
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08114766
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02665857
17MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99116469
18MAF_26560356_Chip-Seq_TH2_Human1.96163111
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95316179
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91309371
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84959137
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.81854175
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81546343
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.81271380
25MYB_26560356_Chip-Seq_TH2_Human1.78740774
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77870208
27DNAJC2_21179169_ChIP-ChIP_NT2_Human1.75163580
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74989798
29LXR_22292898_ChIP-Seq_THP-1_Human1.74166841
30MYB_26560356_Chip-Seq_TH1_Human1.69837173
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.68883874
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.67572066
33KDM2B_26808549_Chip-Seq_K562_Human1.66918009
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66906324
35SPI1_23127762_ChIP-Seq_K562_Human1.66069863
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64908817
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.60159034
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60133306
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60044979
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57026422
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55913957
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55780040
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51556733
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51556733
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50148392
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50009667
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49287386
48KDM2B_26808549_Chip-Seq_DND41_Human1.48610502
49* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48347962
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48324806
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47619551
52EZH2_22144423_ChIP-Seq_EOC_Human1.47111736
53RACK7_27058665_Chip-Seq_MCF-7_Human1.47045100
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46388391
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46140939
56SCL_19346495_ChIP-Seq_HPC-7_Human1.45858345
57BCL6_27268052_Chip-Seq_Bcells_Human1.45545970
58* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44825433
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.43513876
60BCOR_27268052_Chip-Seq_Bcells_Human1.42010348
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41138200
62* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40200020
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39742880
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37316151
65GBX2_23144817_ChIP-Seq_PC3_Human1.36628424
66P68_20966046_ChIP-Seq_HELA_Human1.36083256
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34838627
68VDR_21846776_ChIP-Seq_THP-1_Human1.34206032
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34113650
70TCF7_22412390_ChIP-Seq_EML_Mouse1.34074258
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33614430
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32888464
73GATA3_27048872_Chip-Seq_THYMUS_Human1.32870562
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32243252
75RUNX_20019798_ChIP-Seq_JUKART_Human1.30951480
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30545207
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29675168
78* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29626881
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29001984
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.28180118
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27947543
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27796048
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27741184
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27078891
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26868460
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26261228
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25817680
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.25546006
89BP1_19119308_ChIP-ChIP_Hs578T_Human1.25029998
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.24618592
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24036773
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.23367115
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23150414
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22954790
95VDR_24787735_ChIP-Seq_THP-1_Human1.22256029
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21206788
97AR_21572438_ChIP-Seq_LNCaP_Human1.20969099
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20535911
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19502629
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18249709
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16090365
102* GATA1_19941827_ChIP-Seq_MEL_Mouse1.15957518
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15489829
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15061216
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.13999050
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13509793
107ELF1_20517297_ChIP-Seq_JURKAT_Human1.12912563
108SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12842500
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11868365
110REST_21632747_ChIP-Seq_MESCs_Mouse1.10900729
111GATA1_19941826_ChIP-Seq_K562_Human1.10892089
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10747226
113CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08765169
114* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07730639
115BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06870652
116PU_27001747_Chip-Seq_BMDM_Mouse1.05623898
117IRF8_22096565_ChIP-ChIP_GC-B_Human1.04875518
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04525419
119NCOR1_26117541_ChIP-Seq_K562_Human1.03653628
120ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03533032
121EZH2_27304074_Chip-Seq_ESCs_Mouse1.03512016
122* ERG_21242973_ChIP-ChIP_JURKAT_Human1.03185889
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03090239
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01777426
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01699773
126VDR_24763502_ChIP-Seq_THP-1_Human1.01688676
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01127460
128PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99444767
129GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98225716
130E2F1_20622854_ChIP-Seq_HELA_Human0.97959147
131FOXA2_19822575_ChIP-Seq_HepG2_Human0.97617606
132ELK3_25401928_ChIP-Seq_HUVEC_Human0.97068902
133SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96805782
134FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96335721
135RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93583338
136CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93464784
137SMC4_20622854_ChIP-Seq_HELA_Human0.93222025
138CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92505825
139* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92073928
140NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91232066
141FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89916520
142EED_16625203_ChIP-ChIP_MESCs_Mouse0.89011134
143IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88395118
144RING1B_27294783_Chip-Seq_ESCs_Mouse0.88301280
145SMAD_19615063_ChIP-ChIP_OVARY_Human0.86804282
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86452472
147P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86022324
148RING1B_27294783_Chip-Seq_NPCs_Mouse0.85429408
149* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84929610
150* TET1_21490601_ChIP-Seq_MESCs_Mouse0.84003682
151GATA2_21666600_ChIP-Seq_HMVEC_Human0.83807201
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82664162
153ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82638473
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.81250028
155CTCF_27219007_Chip-Seq_Bcells_Human0.79829637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.51542224
2MP0004859_abnormal_synaptic_plasticity4.24676060
3MP0005058_abnormal_lysosome_morphology3.99496451
4MP0003172_abnormal_lysosome_physiology3.89755847
5MP0003690_abnormal_glial_cell3.39851140
6MP0009840_abnormal_foam_cell3.37380704
7MP0003191_abnormal_cellular_cholesterol2.93495665
8MP0003183_abnormal_peptide_metabolism2.77323769
9MP0003303_peritoneal_inflammation2.73219690
10MP0005360_urolithiasis2.62318528
11MP0009785_altered_susceptibility_to2.57304675
12MP0003075_altered_response_to2.57022900
13MP0005670_abnormal_white_adipose2.39664679
14MP0003763_abnormal_thymus_physiology2.31981598
15MP0004858_abnormal_nervous_system2.25266028
16MP0005167_abnormal_blood-brain_barrier2.23368296
17MP0002148_abnormal_hypersensitivity_rea2.10271395
18MP0006082_CNS_inflammation2.09463874
19MP0002405_respiratory_system_inflammati1.98852810
20MP0000604_amyloidosis1.94659509
21MP0000569_abnormal_digit_pigmentation1.94294189
22MP0004381_abnormal_hair_follicle1.93917952
23MP0005645_abnormal_hypothalamus_physiol1.93282844
24MP0010155_abnormal_intestine_physiology1.88363592
25MP0000716_abnormal_immune_system1.88176656
26MP0002396_abnormal_hematopoietic_system1.86866428
27MP0003252_abnormal_bile_duct1.86592467
28MP0002398_abnormal_bone_marrow1.86231328
29MP0000920_abnormal_myelination1.82864460
30MP0002132_abnormal_respiratory_system1.82263044
31MP0001835_abnormal_antigen_presentation1.81587876
32MP0003634_abnormal_glial_cell1.80363804
33MP0004947_skin_inflammation1.79781004
34MP0009333_abnormal_splenocyte_physiolog1.78729471
35MP0003329_amyloid_beta_deposits1.78605100
36MP0003635_abnormal_synaptic_transmissio1.74718533
37MP0003866_abnormal_defecation1.73514298
38MP0001845_abnormal_inflammatory_respons1.69199849
39MP0002064_seizures1.68454788
40MP0004885_abnormal_endolymph1.66628734
41MP0005085_abnormal_gallbladder_physiolo1.65117652
42MP0002419_abnormal_innate_immunity1.63221494
43MP0004510_myositis1.58834351
44MP0005464_abnormal_platelet_physiology1.58497056
45MP0005451_abnormal_body_composition1.56427301
46MP0002736_abnormal_nociception_after1.55554961
47MP0003300_gastrointestinal_ulcer1.55154314
48MP0002722_abnormal_immune_system1.53173689
49MP0000689_abnormal_spleen_morphology1.53122999
50MP0003828_pulmonary_edema1.50826001
51MP0002429_abnormal_blood_cell1.47517982
52MP0000703_abnormal_thymus_morphology1.47501502
53MP0001873_stomach_inflammation1.47322880
54MP0005310_abnormal_salivary_gland1.47266182
55MP0003436_decreased_susceptibility_to1.39299993
56MP0002063_abnormal_learning/memory/cond1.37457153
57MP0001501_abnormal_sleep_pattern1.36623142
58MP0002277_abnormal_respiratory_mucosa1.34904262
59MP0003633_abnormal_nervous_system1.33504255
60MP0002139_abnormal_hepatobiliary_system1.32498755
61MP0000858_altered_metastatic_potential1.32422331
62MP0005646_abnormal_pituitary_gland1.28562321
63MP0001486_abnormal_startle_reflex1.27512381
64MP0009764_decreased_sensitivity_to1.26089387
65MP0008961_abnormal_basal_metabolism1.24178559
66MP0002909_abnormal_adrenal_gland1.22531120
67MP0002572_abnormal_emotion/affect_behav1.22131502
68MP0010329_abnormal_lipoprotein_level1.21303538
69MP0002735_abnormal_chemical_nociception1.20399454
70MP0005387_immune_system_phenotype1.18917237
71MP0001790_abnormal_immune_system1.18917237
72MP0009278_abnormal_bone_marrow1.18406593
73MP0005365_abnormal_bile_salt1.14802861
74MP0003705_abnormal_hypodermis_morpholog1.14562054
75MP0005166_decreased_susceptibility_to1.14392403
76MP0001986_abnormal_taste_sensitivity1.13077992
77MP0001502_abnormal_circadian_rhythm1.13060133
78MP0001545_abnormal_hematopoietic_system1.08579474
79MP0005397_hematopoietic_system_phenotyp1.08579474
80MP0008874_decreased_physiological_sensi1.08081744
81MP0009745_abnormal_behavioral_response1.07222536
82MP0000955_abnormal_spinal_cord1.04950730
83MP0008438_abnormal_cutaneous_collagen1.03261729
84MP0005377_hearing/vestibular/ear_phenot1.02330233
85MP0003878_abnormal_ear_physiology1.02330233
86MP0002452_abnormal_antigen_presenting1.00615088
87MP0002090_abnormal_vision1.00592949
88MP0003631_nervous_system_phenotype0.99383328
89MP0002118_abnormal_lipid_homeostasis0.99267170
90MP0009046_muscle_twitch0.98928514
91MP0002822_catalepsy0.98690289
92MP0001663_abnormal_digestive_system0.98670033
93MP0002933_joint_inflammation0.98060583
94MP0005671_abnormal_response_to0.97854391
95MP0001968_abnormal_touch/_nociception0.97511260
96MP0005390_skeleton_phenotype0.97283268
97MP0008569_lethality_at_weaning0.97140069
98MP0005075_abnormal_melanosome_morpholog0.95676380
99MP0002272_abnormal_nervous_system0.95210355
100MP0005076_abnormal_cell_differentiation0.94080122
101MP0000465_gastrointestinal_hemorrhage0.93693914
102MP0002254_reproductive_system_inflammat0.92885741
103MP0001533_abnormal_skeleton_physiology0.92195987
104MP0002723_abnormal_immune_serum0.91781422
105MP0001800_abnormal_humoral_immune0.91283409
106MP0003045_fibrosis0.90319297
107MP0005000_abnormal_immune_tolerance0.89584140
108MP0004270_analgesia0.88886805
109MP0008875_abnormal_xenobiotic_pharmacok0.88345922
110MP0003632_abnormal_nervous_system0.87919462
111MP0008260_abnormal_autophagy0.87565935
112MP0005025_abnormal_response_to0.87529982
113MP0004142_abnormal_muscle_tone0.85434254
114MP0002166_altered_tumor_susceptibility0.85427881
115MP0004130_abnormal_muscle_cell0.85003541
116MP0005164_abnormal_response_to0.84842056
117MP0001958_emphysema0.83214645
118MP0002733_abnormal_thermal_nociception0.83077370
119MP0009780_abnormal_chondrocyte_physiolo0.82555834
120MP0003879_abnormal_hair_cell0.82320554
121MP0000609_abnormal_liver_physiology0.82197127
122MP0002998_abnormal_bone_remodeling0.81862772
123MP0002928_abnormal_bile_duct0.81083003
124MP0000778_abnormal_nervous_system0.79795753
125MP0002229_neurodegeneration0.78649925
126MP0000490_abnormal_crypts_of0.78646062
127MP0002138_abnormal_hepatobiliary_system0.77465779
128MP0002067_abnormal_sensory_capabilities0.76410651
129MP0001970_abnormal_pain_threshold0.75846178
130MP0001819_abnormal_immune_cell0.75800188
131MP0002557_abnormal_social/conspecific_i0.75628539
132MP0004883_abnormal_blood_vessel0.75466101
133MP0001440_abnormal_grooming_behavior0.75312232
134MP0003091_abnormal_cell_migration0.73751066
135MP0000685_abnormal_immune_system0.73461371
136MP0008469_abnormal_protein_level0.73272164
137MP0004185_abnormal_adipocyte_glucose0.72776901
138MP0005584_abnormal_enzyme/coenzyme_acti0.72460817
139MP0004808_abnormal_hematopoietic_stem0.72374224
140MP0004811_abnormal_neuron_physiology0.71896239
141MP0002420_abnormal_adaptive_immunity0.71875451
142MP0000015_abnormal_ear_pigmentation0.71701365
143MP0001851_eye_inflammation0.71382818
144MP0000470_abnormal_stomach_morphology0.71138739
145MP0001853_heart_inflammation0.70649630
146MP0001849_ear_inflammation0.69543359
147MP0010368_abnormal_lymphatic_system0.69515996
148MP0003795_abnormal_bone_structure0.69379151
149MP0003448_altered_tumor_morphology0.67402918
150MP0009763_increased_sensitivity_to0.64541244
151MP0000249_abnormal_blood_vessel0.63436332
152MP0005381_digestive/alimentary_phenotyp0.61419645
153MP0005083_abnormal_biliary_tract0.61073348
154MP0008004_abnormal_stomach_pH0.60382813
155MP0003453_abnormal_keratinocyte_physiol0.59497396
156MP0000343_altered_response_to0.58666618
157MP0003806_abnormal_nucleotide_metabolis0.56367576
158MP0005319_abnormal_enzyme/_coenzyme0.53332734

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.68783789
2Systemic lupus erythematosus (HP:0002725)5.14556074
3Orchitis (HP:0100796)5.13376560
4Optic neuritis (HP:0100653)4.72699988
5Retrobulbar optic neuritis (HP:0100654)4.72699988
6Abnormality of liposaccharide metabolism (HP:0010968)4.65258248
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.65258248
8Abnormality of glycolipid metabolism (HP:0010969)4.65258248
9Stomatitis (HP:0010280)4.64550709
10Elevated erythrocyte sedimentation rate (HP:0003565)4.59971990
11Recurrent fungal infections (HP:0002841)4.29643323
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.09050577
13Gastrointestinal infarctions (HP:0005244)4.08813076
14Mediastinal lymphadenopathy (HP:0100721)4.00990814
15Dysostosis multiplex (HP:0000943)3.95130274
16Meningitis (HP:0001287)3.92761554
17Increased cerebral lipofuscin (HP:0011813)3.91279444
18Obstructive lung disease (HP:0006536)3.91069239
19Chronic obstructive pulmonary disease (HP:0006510)3.91069239
20Recurrent cutaneous fungal infections (HP:0011370)3.81975949
21Chronic mucocutaneous candidiasis (HP:0002728)3.81975949
22Glomerulonephritis (HP:0000099)3.71057991
23Complement deficiency (HP:0004431)3.67058821
24Supranuclear gaze palsy (HP:0000605)3.64853396
25Spontaneous hematomas (HP:0007420)3.61190605
26Increased IgE level (HP:0003212)3.60727614
27Encephalitis (HP:0002383)3.52254233
28Hypochromic anemia (HP:0001931)3.39744557
29Loss of speech (HP:0002371)3.36712071
30Neurofibrillary tangles (HP:0002185)3.30735439
31Increased neuronal autofluorescent lipopigment (HP:0002074)3.30247427
32Cerebral aneurysm (HP:0004944)3.29346627
33Hypochromic microcytic anemia (HP:0004840)3.27909215
34Vasculitis (HP:0002633)3.25575869
35Keratoconjunctivitis sicca (HP:0001097)3.25097864
36Prolonged bleeding time (HP:0003010)3.21595439
37Urticaria (HP:0001025)3.18419689
38Pustule (HP:0200039)3.17984141
39Cellulitis (HP:0100658)3.16658147
40Abnormality of polysaccharide metabolism (HP:0011012)3.14807155
41Abnormality of glycosaminoglycan metabolism (HP:0004371)3.14807155
42Abnormality of mucopolysaccharide metabolism (HP:0011020)3.14807155
43Retinal atrophy (HP:0001105)3.12832781
44Abnormality of complement system (HP:0005339)3.11099967
45Mucopolysacchariduria (HP:0008155)3.11073988
46Urinary glycosaminoglycan excretion (HP:0003541)3.11073988
47Mutism (HP:0002300)3.08933163
48Keratoconjunctivitis (HP:0001096)3.07070652
49Amyloidosis (HP:0011034)3.04451622
50Hemoptysis (HP:0002105)3.04323927
51Axonal loss (HP:0003447)3.03353529
52Chest pain (HP:0100749)3.02641309
53Neuronal loss in central nervous system (HP:0002529)3.01088533
54Recurrent bacterial skin infections (HP:0005406)3.00433844
55Panhypogammaglobulinemia (HP:0003139)2.89596652
56Pulmonary infiltrates (HP:0002113)2.83019965
57Recurrent abscess formation (HP:0002722)2.79844294
58Episodic fever (HP:0001954)2.76909002
59Peritonitis (HP:0002586)2.64792154
60Recurrent viral infections (HP:0004429)2.64223491
61Arterial thrombosis (HP:0004420)2.62231761
62Pulmonary embolism (HP:0002204)2.61555497
63Cerebral inclusion bodies (HP:0100314)2.60134908
64Frequent falls (HP:0002359)2.59437406
65Anorexia (HP:0002039)2.59241403
66T lymphocytopenia (HP:0005403)2.58858407
67Epistaxis (HP:0000421)2.57136723
68Deep venous thrombosis (HP:0002625)2.55733713
69Postural instability (HP:0002172)2.53769607
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.45466721
71Abnormality of T cell number (HP:0011839)2.45130579
72Leukocytosis (HP:0001974)2.41849579
73Colitis (HP:0002583)2.39480556
74Petechiae (HP:0000967)2.38996181
75Abnormality of T cells (HP:0002843)2.38743028
76Progressive neurologic deterioration (HP:0002344)2.37802713
77Cardiomegaly (HP:0001640)2.36636690
78Osteomyelitis (HP:0002754)2.34424002
79Apathy (HP:0000741)2.31238597
80Status epilepticus (HP:0002133)2.30584175
81Lymphopenia (HP:0001888)2.30283355
82Microcytic anemia (HP:0001935)2.24573893
83Granulocytopenia (HP:0001913)2.21231216
84Sepsis (HP:0100806)2.20182437
85Premature loss of primary teeth (HP:0006323)2.19997925
86Centrally nucleated skeletal muscle fibers (HP:0003687)2.19704255
87Eczematoid dermatitis (HP:0000976)2.19231640
88Vacuolated lymphocytes (HP:0001922)2.19208099
89Nephritis (HP:0000123)2.19035079
90Abnormality of the pleura (HP:0002103)2.18382313
91Cheilitis (HP:0100825)2.18303698
92Sensorimotor neuropathy (HP:0007141)2.17116710
93Increased serum ferritin (HP:0003281)2.16179727
94Peripheral demyelination (HP:0011096)2.16019741
95Abnormality of T cell physiology (HP:0011840)2.14776614
96Abnormality of the endocardium (HP:0004306)2.14227975
97Arterial tortuosity (HP:0005116)2.14086330
98Abnormality of cells of the lymphoid lineage (HP:0012140)2.13361179
99Disinhibition (HP:0000734)2.12275644
100Increased IgM level (HP:0003496)2.10740002
101Clumsiness (HP:0002312)2.10609289
102Disproportionate tall stature (HP:0001519)2.09919711
103Diminished motivation (HP:0000745)2.08987680
104Hemiplegia (HP:0002301)2.08026062
105Restrictive lung disease (HP:0002091)2.06128709
106Inflammation of the large intestine (HP:0002037)2.05816077
107Purpura (HP:0000979)2.05586945
108Hyperacusis (HP:0010780)2.02850180
109Abnormality of the peritoneum (HP:0002585)2.02081183
110Gastrointestinal inflammation (HP:0004386)2.01714692
111Agammaglobulinemia (HP:0004432)2.01627353
112Malnutrition (HP:0004395)2.01246920
113Hypergammaglobulinemia (HP:0010702)2.00791959
114Pathologic fracture (HP:0002756)2.00707372
115Recurrent gram-negative bacterial infections (HP:0005420)1.99546741
116Recurrent skin infections (HP:0001581)1.99528262
117Dementia (HP:0000726)1.98429448
118Mitral stenosis (HP:0001718)1.97823923
119Abnormality of iron homeostasis (HP:0011031)1.97071732
120Gingivitis (HP:0000230)1.96321045
121Acne (HP:0001061)1.96281372
122Metaphyseal cupping (HP:0003021)1.96265286
123Limb-girdle muscle atrophy (HP:0003797)1.96023620
124Abnormality of the pericardium (HP:0001697)1.95335475
125Abnormality of macrophages (HP:0004311)1.95175524
126Asymmetric septal hypertrophy (HP:0001670)1.95137028
127Skin ulcer (HP:0200042)1.94972093
128Hematochezia (HP:0002573)1.92857304
129Chronic otitis media (HP:0000389)1.92833163
130Hemiparesis (HP:0001269)1.92592567
131Papilledema (HP:0001085)1.91325820
132Hepatosplenomegaly (HP:0001433)1.91040408
133Exotropia (HP:0000577)1.89991321
134Polygenic inheritance (HP:0010982)1.89114295
135Viral hepatitis (HP:0006562)1.88952032
136Turricephaly (HP:0000262)1.88605694
137Abnormality of the fingertips (HP:0001211)1.88545050
138Myocardial infarction (HP:0001658)1.88521757
139Xanthomatosis (HP:0000991)1.88101746
140Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87888254
141Gastrointestinal stroma tumor (HP:0100723)1.87705603
142Gangrene (HP:0100758)1.87547741
143Interstitial pulmonary disease (HP:0006530)1.86588125
144Slow saccadic eye movements (HP:0000514)1.85888523
145Abnormality of the Achilles tendon (HP:0005109)1.82772354
146Vertigo (HP:0002321)1.82041171
147Basal ganglia calcification (HP:0002135)1.81634169
148Keratitis (HP:0000491)1.81306901
149Hydroxyprolinuria (HP:0003080)1.80282586
150Abnormality of proline metabolism (HP:0010907)1.80282586
151Action tremor (HP:0002345)1.79972250
152Cerebellar dysplasia (HP:0007033)1.78938831
153Striae distensae (HP:0001065)1.78736336
154Onion bulb formation (HP:0003383)1.77543167
155Achilles tendon contracture (HP:0001771)1.76961715
156Rigidity (HP:0002063)1.76649555
157Abnormality of the periventricular white matter (HP:0002518)1.75420701
158Type II lissencephaly (HP:0007260)1.74140833
159Periodontitis (HP:0000704)1.73783385
160Insomnia (HP:0100785)1.72914166
161Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72419669
162Increased CSF protein (HP:0002922)1.72109613
163Vascular tortuosity (HP:0004948)1.71944246
164Paraparesis (HP:0002385)1.71745407
165Upper limb amyotrophy (HP:0009129)1.70981004
166Distal upper limb amyotrophy (HP:0007149)1.70981004
167Gingival bleeding (HP:0000225)1.68053434
168Broad metatarsal (HP:0001783)1.67021163
169Abnormality of aromatic amino acid family metabolism (HP:0004338)1.65709662
170Arnold-Chiari malformation (HP:0002308)1.65550336
171Intrahepatic cholestasis (HP:0001406)1.64496655
172J-shaped sella turcica (HP:0002680)1.62911457
173Hypoalphalipoproteinemia (HP:0003233)1.62782300
174Spastic tetraparesis (HP:0001285)1.62655346
175Myokymia (HP:0002411)1.62114526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.03131947
2MAP2K32.78121954
3MAPK152.54542022
4TGFBR22.42349607
5CAMK1D2.41375049
6WNK32.23855571
7SIK12.23455607
8GRK62.22900891
9CAMK1G2.19490205
10CSF1R2.16674771
11PRPF4B2.14634866
12TRIB32.09375723
13TYK22.00374249
14ZAP701.96630249
15MAP3K131.94218024
16EEF2K1.91857648
17BTK1.80687835
18EPHB11.78937349
19RIPK41.78455687
20TAOK11.77389541
21SIK21.74703091
22JAK11.73988424
23MAP3K31.71425668
24JAK31.68827777
25KSR21.62894510
26MAP3K111.61082668
27MAP4K11.56051303
28PAK61.54542107
29PTK61.53413270
30MAP3K91.53036879
31SMG11.51966128
32NTRK21.48192209
33CAMKK11.45854989
34TXK1.42953022
35FES1.42572129
36EPHA41.40539051
37CAMKK21.40249949
38TAOK31.37726511
39ICK1.36045187
40PKN11.35461542
41NTRK31.33929967
42HCK1.31915385
43DAPK21.31855057
44MAP3K141.28938595
45KIT1.23290820
46BLK1.13704914
47MAP3K11.12422329
48CASK1.10640824
49LCK1.07007605
50FGFR41.04732968
51DMPK1.03224376
52CSNK1A1L1.01604207
53SIK31.00339163
54CDC42BPA0.97949235
55TBK10.96482167
56PRKCH0.94875654
57FGFR20.92831024
58JAK20.90771147
59PDPK10.89933135
60TAOK20.89744557
61MOS0.89716204
62MARK30.87583677
63IKBKB0.87297433
64PKN20.85208209
65PRKD30.84380633
66RET0.84345327
67NTRK10.83939110
68IRAK40.82808300
69PRKD20.81323451
70PHKG10.80972581
71PHKG20.80972581
72CSNK1G20.79678007
73MAPK120.79266290
74LMTK20.79081186
75CLK10.78397097
76MAP3K60.77440731
77MAP2K60.76835866
78YES10.76612898
79PDK10.76219050
80CAMK40.75786464
81PRKD10.75376401
82CDK50.72639247
83CSK0.69797336
84IRAK20.68638510
85CAMK10.68149976
86TYRO30.68079983
87IRAK10.67411659
88ALK0.65535077
89BMPR20.65375599
90RPS6KL10.65046582
91RPS6KC10.65046582
92PTK2B0.64820166
93TEC0.64338827
94STK380.64179624
95MAPK70.63146471
96IKBKE0.62835336
97MARK20.62690845
98SGK30.61896450
99SYK0.61820701
100KSR10.60955635
101RPS6KA60.60928153
102SCYL20.60735099
103CSNK1G30.60611552
104TNK20.60407578
105STK110.59260495
106MAP2K20.58812940
107CSNK1G10.58061321
108RPS6KA20.56978395
109MAP3K70.56664903
110TESK20.54808709
111ABL10.54315468
112FYN0.53821927
113FGFR30.53358251
114LRRK20.53318403
115LYN0.53036394
116DYRK1B0.52857632
117MATK0.50488929
118PDGFRA0.50258602
119PRKG20.50112637
120EPHB20.49900411
121HIPK20.49167252
122SGK2230.49016672
123SGK4940.49016672
124ITK0.48543581
125UHMK10.48184588
126ERBB20.45624949
127TRPM70.45352978
128PRKCQ0.44742235
129MAP3K20.44407595
130MAP3K100.44343274
131PAK40.43080702
132MAPKAPK20.42951226
133FGR0.41838200
134PRKCZ0.40868379
135BMX0.40604350
136CDK120.40564550
137MAPK110.40514002
138STK100.40507759
139RIPK10.38997592
140MAP2K40.38716313
141IRAK30.38640761
142CDK190.35967714
143CHUK0.35949434
144CDK40.30605620

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.28672558
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.63807835
3Staphylococcus aureus infection_Homo sapiens_hsa051502.48501274
4Graft-versus-host disease_Homo sapiens_hsa053322.21620710
5Allograft rejection_Homo sapiens_hsa053302.17746537
6Lysosome_Homo sapiens_hsa041422.17549845
7Autoimmune thyroid disease_Homo sapiens_hsa053202.06359561
8Primary immunodeficiency_Homo sapiens_hsa053402.06098183
9Arginine biosynthesis_Homo sapiens_hsa002201.98239405
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.95700365
11Acute myeloid leukemia_Homo sapiens_hsa052211.89500794
12Other glycan degradation_Homo sapiens_hsa005111.85823556
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85801592
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72049161
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69377660
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.65443868
17T cell receptor signaling pathway_Homo sapiens_hsa046601.62492129
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60292169
19Type I diabetes mellitus_Homo sapiens_hsa049401.57232482
20Malaria_Homo sapiens_hsa051441.56546100
21Measles_Homo sapiens_hsa051621.53818840
22Hematopoietic cell lineage_Homo sapiens_hsa046401.49424107
23Toxoplasmosis_Homo sapiens_hsa051451.48791876
24Antigen processing and presentation_Homo sapiens_hsa046121.48198633
25Complement and coagulation cascades_Homo sapiens_hsa046101.46607725
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.44453157
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38541925
28Prion diseases_Homo sapiens_hsa050201.38329645
29Influenza A_Homo sapiens_hsa051641.37318585
30Viral myocarditis_Homo sapiens_hsa054161.35545873
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33019890
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.32559247
33ABC transporters_Homo sapiens_hsa020101.29411609
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25969988
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.24362050
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24136642
37Osteoclast differentiation_Homo sapiens_hsa043801.23549051
38B cell receptor signaling pathway_Homo sapiens_hsa046621.20774755
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20673900
40Herpes simplex infection_Homo sapiens_hsa051681.20187445
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20107802
42TNF signaling pathway_Homo sapiens_hsa046681.17835390
43VEGF signaling pathway_Homo sapiens_hsa043701.17528914
44Glutamatergic synapse_Homo sapiens_hsa047241.16934311
45Hepatitis C_Homo sapiens_hsa051601.11879487
46Lysine degradation_Homo sapiens_hsa003101.11830636
47Cocaine addiction_Homo sapiens_hsa050301.10584906
48African trypanosomiasis_Homo sapiens_hsa051431.09027265
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08485780
50Asthma_Homo sapiens_hsa053101.08019446
51Legionellosis_Homo sapiens_hsa051341.03562525
52Type II diabetes mellitus_Homo sapiens_hsa049301.01045105
53Bile secretion_Homo sapiens_hsa049761.00942591
54Hepatitis B_Homo sapiens_hsa051610.99358665
55Leishmaniasis_Homo sapiens_hsa051400.99130584
56GABAergic synapse_Homo sapiens_hsa047270.94528360
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93965304
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93048564
59Fatty acid metabolism_Homo sapiens_hsa012120.92211289
60Circadian entrainment_Homo sapiens_hsa047130.90751901
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88942493
62Notch signaling pathway_Homo sapiens_hsa043300.88627382
63Salivary secretion_Homo sapiens_hsa049700.88010755
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87977214
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87096748
66Synaptic vesicle cycle_Homo sapiens_hsa047210.86724031
67PPAR signaling pathway_Homo sapiens_hsa033200.85886575
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85752648
69Morphine addiction_Homo sapiens_hsa050320.84490164
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.83373444
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83321912
72Chemokine signaling pathway_Homo sapiens_hsa040620.82663832
73Apoptosis_Homo sapiens_hsa042100.82385955
74Prolactin signaling pathway_Homo sapiens_hsa049170.80466711
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79199083
76Pertussis_Homo sapiens_hsa051330.79166641
77Rheumatoid arthritis_Homo sapiens_hsa053230.78802150
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76279736
79Shigellosis_Homo sapiens_hsa051310.75576694
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74464705
81Endometrial cancer_Homo sapiens_hsa052130.73743018
82Salmonella infection_Homo sapiens_hsa051320.72813088
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72669114
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72578032
85Olfactory transduction_Homo sapiens_hsa047400.72528576
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71921178
87Tryptophan metabolism_Homo sapiens_hsa003800.71745339
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.71735910
89Chronic myeloid leukemia_Homo sapiens_hsa052200.71697293
90Histidine metabolism_Homo sapiens_hsa003400.71612049
91Nicotine addiction_Homo sapiens_hsa050330.70254101
92Fatty acid degradation_Homo sapiens_hsa000710.68862945
93Renin secretion_Homo sapiens_hsa049240.67157461
94Dorso-ventral axis formation_Homo sapiens_hsa043200.67062647
95Butanoate metabolism_Homo sapiens_hsa006500.66834982
96Axon guidance_Homo sapiens_hsa043600.66749356
97mTOR signaling pathway_Homo sapiens_hsa041500.65713702
98Long-term depression_Homo sapiens_hsa047300.65643889
99Long-term potentiation_Homo sapiens_hsa047200.65561313
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64714296
101Choline metabolism in cancer_Homo sapiens_hsa052310.64712038
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64426577
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63139125
104Tuberculosis_Homo sapiens_hsa051520.63092298
105cAMP signaling pathway_Homo sapiens_hsa040240.61642243
106FoxO signaling pathway_Homo sapiens_hsa040680.61251043
107Endocytosis_Homo sapiens_hsa041440.60496858
108Glioma_Homo sapiens_hsa052140.59537638
109Estrogen signaling pathway_Homo sapiens_hsa049150.58817840
110Insulin secretion_Homo sapiens_hsa049110.58478221
111Epstein-Barr virus infection_Homo sapiens_hsa051690.58175146
112Cholinergic synapse_Homo sapiens_hsa047250.58057072
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57215914
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56523474
115Insulin resistance_Homo sapiens_hsa049310.56444995
116Amphetamine addiction_Homo sapiens_hsa050310.55915815
117Gastric acid secretion_Homo sapiens_hsa049710.55127035
118Oxytocin signaling pathway_Homo sapiens_hsa049210.55088314
119beta-Alanine metabolism_Homo sapiens_hsa004100.54655418
120HTLV-I infection_Homo sapiens_hsa051660.54519806
121Amoebiasis_Homo sapiens_hsa051460.53696788
122Fatty acid biosynthesis_Homo sapiens_hsa000610.53074829
123Viral carcinogenesis_Homo sapiens_hsa052030.52845650
124MAPK signaling pathway_Homo sapiens_hsa040100.52602104
125Renal cell carcinoma_Homo sapiens_hsa052110.52390342
126Platelet activation_Homo sapiens_hsa046110.52322874
127Rap1 signaling pathway_Homo sapiens_hsa040150.52068616
128GnRH signaling pathway_Homo sapiens_hsa049120.51663020
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.51136228
130Non-small cell lung cancer_Homo sapiens_hsa052230.50833773
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50494953
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49359362
133ErbB signaling pathway_Homo sapiens_hsa040120.49355412
134Arginine and proline metabolism_Homo sapiens_hsa003300.49158242
135Phagosome_Homo sapiens_hsa041450.49015293
136Pancreatic cancer_Homo sapiens_hsa052120.48892721
137Colorectal cancer_Homo sapiens_hsa052100.48600607
138Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48357109
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47225132
140HIF-1 signaling pathway_Homo sapiens_hsa040660.46585586
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46226935
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46214323
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45602106
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.44148077
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.43113568
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41720188
147Inositol phosphate metabolism_Homo sapiens_hsa005620.41619940
148Insulin signaling pathway_Homo sapiens_hsa049100.41049024
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.40950375
150Regulation of autophagy_Homo sapiens_hsa041400.37979280
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36817294
152Prostate cancer_Homo sapiens_hsa052150.36290260

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