SLC12A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.06263084
2ensheathment of neurons (GO:0007272)6.97538876
3axon ensheathment (GO:0008366)6.97538876
4myelination (GO:0042552)6.93341045
5intestinal epithelial cell development (GO:0060576)5.73759070
6long-chain fatty acid biosynthetic process (GO:0042759)5.46961192
7myelin maintenance (GO:0043217)5.25106757
8negative regulation of neurotransmitter secretion (GO:0046929)5.06419910
9asymmetric protein localization (GO:0008105)4.87341824
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.82412463
11apical protein localization (GO:0045176)4.58375567
12glycerophospholipid catabolic process (GO:0046475)4.58035566
13eye photoreceptor cell differentiation (GO:0001754)4.57688528
14photoreceptor cell differentiation (GO:0046530)4.57688528
15cholesterol biosynthetic process (GO:0006695)4.46355739
16positive regulation of glycoprotein biosynthetic process (GO:0010560)4.42788298
17negative regulation of neurotransmitter transport (GO:0051589)4.37596946
18creatine metabolic process (GO:0006600)4.35489146
19negative regulation of keratinocyte proliferation (GO:0010839)4.28594659
20desmosome organization (GO:0002934)4.24170288
21oligodendrocyte differentiation (GO:0048709)4.22720970
22astrocyte development (GO:0014002)4.18816746
23negative regulation of protein localization to cell surface (GO:2000009)4.10724001
24auditory receptor cell differentiation (GO:0042491)4.01536446
25regulation of collateral sprouting (GO:0048670)3.95797408
26regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.92814596
27sterol biosynthetic process (GO:0016126)3.89609165
28long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.86001030
29virion attachment to host cell (GO:0019062)3.85659947
30adhesion of symbiont to host cell (GO:0044650)3.85659947
31peripheral nervous system axon ensheathment (GO:0032292)3.76778511
32myelination in peripheral nervous system (GO:0022011)3.76778511
33peptidyl-tyrosine autophosphorylation (GO:0038083)3.76153169
34negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.75416281
35L-amino acid import (GO:0043092)3.74191337
36import into cell (GO:0098657)3.66159444
37positive regulation of glycoprotein metabolic process (GO:1903020)3.61403862
38long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.60839326
39positive regulation of actin filament depolymerization (GO:0030836)3.58942807
40prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.54680380
41limb bud formation (GO:0060174)3.51759155
42cellular glucuronidation (GO:0052695)3.51410061
43regulation of keratinocyte proliferation (GO:0010837)3.51097657
44establishment of mitochondrion localization (GO:0051654)3.50237860
45amyloid precursor protein metabolic process (GO:0042982)3.48190366
46response to redox state (GO:0051775)3.47777700
47magnesium ion transport (GO:0015693)3.46993231
48UDP-N-acetylglucosamine metabolic process (GO:0006047)3.45924449
49presynaptic membrane organization (GO:0097090)3.43468374
50isoprenoid biosynthetic process (GO:0008299)3.41039784
51substantia nigra development (GO:0021762)3.40969242
52positive regulation of oligodendrocyte differentiation (GO:0048714)3.38581921
53calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.37741015
54embryonic foregut morphogenesis (GO:0048617)3.34252848
55fatty-acyl-CoA biosynthetic process (GO:0046949)3.29141741
56uronic acid metabolic process (GO:0006063)3.28900276
57glucuronate metabolic process (GO:0019585)3.28900276
58presynaptic membrane assembly (GO:0097105)3.28687165
59response to lipoprotein particle (GO:0055094)3.25802961
60transcytosis (GO:0045056)3.24722002
61protein palmitoylation (GO:0018345)3.13029621
62nucleotide transmembrane transport (GO:1901679)3.12967701
63protein localization to endosome (GO:0036010)3.11651876
64L-serine transport (GO:0015825)3.11335791
65membrane tubulation (GO:0097320)3.11123599
66regulation of bile acid biosynthetic process (GO:0070857)3.10847922
67response to methylmercury (GO:0051597)3.10678435
68fatty-acyl-CoA metabolic process (GO:0035337)3.06542325
69GPI anchor metabolic process (GO:0006505)3.01884742
70GPI anchor biosynthetic process (GO:0006506)3.00683715
71glomerular filtration (GO:0003094)3.00421348
72flavonoid metabolic process (GO:0009812)2.99911718
73intestinal absorption (GO:0050892)2.99082344
74peripheral nervous system development (GO:0007422)2.98964183
75nerve growth factor signaling pathway (GO:0038180)2.97892098
76O-glycan processing (GO:0016266)2.95489876
77labyrinthine layer development (GO:0060711)2.95032719
78negative regulation of hormone metabolic process (GO:0032351)2.90140700
79fucose catabolic process (GO:0019317)2.90135867
80L-fucose metabolic process (GO:0042354)2.90135867
81L-fucose catabolic process (GO:0042355)2.90135867
82cerebral cortex radially oriented cell migration (GO:0021799)2.89714638
83organ growth (GO:0035265)2.88305963
84cytoskeletal anchoring at plasma membrane (GO:0007016)2.88003110
85Golgi to endosome transport (GO:0006895)2.85812052
86regulation of guanylate cyclase activity (GO:0031282)2.85475253
87phosphatidylserine metabolic process (GO:0006658)2.84548319
88regulation of protein glycosylation (GO:0060049)2.84533344
89tight junction assembly (GO:0070830)2.83911244
90cellular response to epinephrine stimulus (GO:0071872)2.82150244
91regulation of pigment cell differentiation (GO:0050932)2.80672347
92neuron remodeling (GO:0016322)2.78509145
93negative regulation of axonogenesis (GO:0050771)2.76172443
94keratinocyte development (GO:0003334)2.73923709
95adhesion of symbiont to host (GO:0044406)2.72515983
96Leydig cell differentiation (GO:0033327)2.72400117
97drug transmembrane transport (GO:0006855)2.72155442
98axon development (GO:0061564)2.71351151
99renal filtration (GO:0097205)2.69832844
100thioester biosynthetic process (GO:0035384)2.69779273
101acyl-CoA biosynthetic process (GO:0071616)2.69779273
102adult walking behavior (GO:0007628)2.68829480
103branching involved in prostate gland morphogenesis (GO:0060442)2.68791316
104digestion (GO:0007586)2.68554330
105amino acid import (GO:0043090)2.68428788
106inner ear receptor cell differentiation (GO:0060113)2.68362116
107artery development (GO:0060840)2.67949047
108hair cell differentiation (GO:0035315)2.66967921
109positive regulation of action potential (GO:0045760)2.66859985
110angiotensin maturation (GO:0002003)2.66661080
111Golgi to plasma membrane protein transport (GO:0043001)2.66530387
112transmission of nerve impulse (GO:0019226)2.65976069
113positive regulation of protein autophosphorylation (GO:0031954)2.65619699
114negative regulation of JUN kinase activity (GO:0043508)2.63697785
115regulation of lipoprotein metabolic process (GO:0050746)2.63544188
116positive regulation of pseudopodium assembly (GO:0031274)2.63117172
117inositol phosphate-mediated signaling (GO:0048016)2.61700264
1183-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.60981794
119purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.60981794
120maintenance of gastrointestinal epithelium (GO:0030277)2.60252083
121mammary gland alveolus development (GO:0060749)2.58604375
122negative regulation of axon extension (GO:0030517)2.56866902
123regulation of somitogenesis (GO:0014807)2.56826101
124organ formation (GO:0048645)2.56566496
125lipid translocation (GO:0034204)2.56538185
126phospholipid translocation (GO:0045332)2.56538185
127negative regulation of hormone biosynthetic process (GO:0032353)2.54554135
128preassembly of GPI anchor in ER membrane (GO:0016254)2.52011353
129membrane protein ectodomain proteolysis (GO:0006509)2.50817608
130positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.50760875
131regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.50477224
132regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.50183663
133positive regulation of neurological system process (GO:0031646)2.50078130
134interleukin-6-mediated signaling pathway (GO:0070102)2.49428071
135positive regulation of glial cell differentiation (GO:0045687)2.48318275
136zinc ion transport (GO:0006829)2.48159167
137lateral sprouting from an epithelium (GO:0060601)2.47128092
138positive regulation of gliogenesis (GO:0014015)2.46923531
139ear development (GO:0043583)2.46906564
140very long-chain fatty acid metabolic process (GO:0000038)2.46592089
141oocyte development (GO:0048599)2.45915339
142regulation of transforming growth factor beta2 production (GO:0032909)2.45874490
143positive regulation of guanylate cyclase activity (GO:0031284)2.45312765
144serine transport (GO:0032329)2.45191325
145smooth muscle tissue development (GO:0048745)2.45165645
146neuronal ion channel clustering (GO:0045161)2.44504570
147glial cell development (GO:0021782)2.44326804
148sphingosine metabolic process (GO:0006670)2.44282512
149membrane assembly (GO:0071709)2.43824709
150extracellular matrix assembly (GO:0085029)2.43747577
151lung lobe morphogenesis (GO:0060463)2.42962529
152dorsal/ventral axis specification (GO:0009950)2.41755490
153columnar/cuboidal epithelial cell development (GO:0002066)2.39032585
154bile acid and bile salt transport (GO:0015721)2.37001302
155striated muscle atrophy (GO:0014891)2.36534550
156renal system process involved in regulation of blood volume (GO:0001977)2.32683060
157branch elongation of an epithelium (GO:0060602)2.31998649
158sphingomyelin metabolic process (GO:0006684)2.30308569
159cell-cell junction assembly (GO:0007043)2.30290260
160genitalia morphogenesis (GO:0035112)2.30112888
161nephron tubule formation (GO:0072079)2.29805061
162kidney morphogenesis (GO:0060993)2.28204191
163oligosaccharide biosynthetic process (GO:0009312)2.27929022
164ventricular cardiac muscle cell action potential (GO:0086005)2.25439252
165regulation of systemic arterial blood pressure by hormone (GO:0001990)2.23394545
166regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.23394545
167endocrine process (GO:0050886)2.23394545
168regulation of Rac protein signal transduction (GO:0035020)2.22159238
169COPII vesicle coating (GO:0048208)2.21870011
170regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.21568066
171regulation of heart rate by cardiac conduction (GO:0086091)2.19782812
172ectoderm development (GO:0007398)2.16557144
173vascular smooth muscle contraction (GO:0014829)2.16219460
174gap junction assembly (GO:0016264)2.16021264
175regulation of keratinocyte differentiation (GO:0045616)2.15867246
176cobalamin metabolic process (GO:0009235)2.13954620
177protein O-linked glycosylation (GO:0006493)2.13625347
178sulfate transmembrane transport (GO:1902358)2.12375975
179positive regulation of glycolytic process (GO:0045821)2.11454088
180cardiac conduction (GO:0061337)2.11442440
181regulation of establishment or maintenance of cell polarity (GO:0032878)2.11440266
182skeletal muscle adaptation (GO:0043501)2.10973666
183retina vasculature morphogenesis in camera-type eye (GO:0061299)2.08680452
184glucocorticoid biosynthetic process (GO:0006704)2.08312750
185regulation of cardioblast differentiation (GO:0051890)2.07724126
186prostate gland growth (GO:0060736)2.07722583
187axon ensheathment in central nervous system (GO:0032291)10.8052991
188central nervous system myelination (GO:0022010)10.8052991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human2.64910180
2SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.63407456
3* CDX2_20551321_ChIP-Seq_CACO-2_Human2.46775511
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43303019
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26983499
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.25005055
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18917666
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.14757039
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07098469
10OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.05982328
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05541270
12TAF15_26573619_Chip-Seq_HEK293_Human2.04148268
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.02472460
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.01312134
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.98916318
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88729613
17AR_21909140_ChIP-Seq_LNCAP_Human1.84068363
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82455777
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81935718
20STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.73892527
21* GATA4_25053715_ChIP-Seq_YYC3_Human1.73363345
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.72877592
23AR_21572438_ChIP-Seq_LNCaP_Human1.71687061
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70693468
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67354331
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.66247562
27* CDX2_22108803_ChIP-Seq_LS180_Human1.66119472
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64582672
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.64507605
30EWS_26573619_Chip-Seq_HEK293_Human1.64448307
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63697449
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63556833
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63022917
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63022917
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.62905749
36ER_23166858_ChIP-Seq_MCF-7_Human1.60663084
37AHR_22903824_ChIP-Seq_MCF-7_Human1.60248001
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59155687
39BCAT_22108803_ChIP-Seq_LS180_Human1.57625103
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.56427902
41CJUN_26792858_Chip-Seq_BT549_Human1.53831801
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.52439129
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.51958814
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.51391914
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50747262
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50007521
47* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48120096
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47900366
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.47709887
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.47320144
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.47227548
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45821192
53IGF1R_20145208_ChIP-Seq_DFB_Human1.44752563
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42201511
55GATA6_25053715_ChIP-Seq_YYC3_Human1.38744427
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.38720624
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38617191
58AR_25329375_ChIP-Seq_VCAP_Human1.38556777
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.37421565
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36834086
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36834086
62DROSHA_22980978_ChIP-Seq_HELA_Human1.36751859
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.36625175
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35511625
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34192156
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33910517
67* SOX2_20726797_ChIP-Seq_SW620_Human1.33779208
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32541101
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32456376
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31023204
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30844948
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.30842303
73TCF4_22108803_ChIP-Seq_LS180_Human1.30653136
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.30227889
75FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.29603617
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28322895
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26973187
78* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24852587
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23716504
80CBP_20019798_ChIP-Seq_JUKART_Human1.23275416
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23275416
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22706053
83FUS_26573619_Chip-Seq_HEK293_Human1.21250302
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.21057287
85TP53_16413492_ChIP-PET_HCT116_Human1.20826902
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18421431
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17912208
88GATA3_24758297_ChIP-Seq_MCF-7_Human1.17658638
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16254870
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16080448
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16044778
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16021875
93EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15957533
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15953947
95STAT3_23295773_ChIP-Seq_U87_Human1.14402549
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.13970753
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13844134
98VDR_22108803_ChIP-Seq_LS180_Human1.13828562
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13569193
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13073652
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13030861
102FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12552971
103RXR_22108803_ChIP-Seq_LS180_Human1.12349239
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.12019393
105SMAD3_21741376_ChIP-Seq_HESCs_Human1.11853571
106CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10903719
107PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10703967
108P300_19829295_ChIP-Seq_ESCs_Human1.10226902
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10079422
110* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09957223
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09504231
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09484214
113P53_22387025_ChIP-Seq_ESCs_Mouse1.08966636
114EZH2_22144423_ChIP-Seq_EOC_Human1.08590450
115TP53_18474530_ChIP-ChIP_U2OS_Human1.07508162
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06788005
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.06756597
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.06270774
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05747948
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04667977
121NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04451603
122SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04078047
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03123607
124LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02552164
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02310550
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02228319
127FOXA1_25552417_ChIP-Seq_VCAP_Human1.01834110
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01347735
129CMYC_18555785_Chip-Seq_ESCs_Mouse1.01312825
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01069183
131SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99963490
132* SMAD4_21799915_ChIP-Seq_A2780_Human0.99604079
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99577977
134TAL1_26923725_Chip-Seq_HPCs_Mouse0.99326708
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98963458
136* TCF4_23295773_ChIP-Seq_U87_Human0.98495888
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97887018
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97002436
139FOXA2_19822575_ChIP-Seq_HepG2_Human0.96902383
140TP63_23658742_ChIP-Seq_EP156T_Human0.96845692
141KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96616845
142KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96616845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.05419560
2MP0003950_abnormal_plasma_membrane3.64898037
3MP0000462_abnormal_digestive_system3.41762386
4MP0004885_abnormal_endolymph3.37468972
5MP0010678_abnormal_skin_adnexa3.21647941
6MP0003690_abnormal_glial_cell3.09675783
7MP0010352_gastrointestinal_tract_polyps3.01415619
8MP0000537_abnormal_urethra_morphology2.98793454
9MP0004742_abnormal_vestibular_system2.84047098
10MP0004270_analgesia2.83032688
11MP0000566_synostosis2.72761650
12MP0001666_abnormal_nutrient_absorption2.58410911
13MP0005171_absent_coat_pigmentation2.56736044
14MP0000383_abnormal_hair_follicle2.50823342
15MP0003880_abnormal_central_pattern2.41867849
16MP0005085_abnormal_gallbladder_physiolo2.36541720
17MP0003329_amyloid_beta_deposits2.35014686
18MP0008057_abnormal_DNA_replication2.34558048
19MP0005360_urolithiasis2.32420743
20MP0010234_abnormal_vibrissa_follicle2.25827832
21MP0001346_abnormal_lacrimal_gland2.12909856
22MP0003634_abnormal_glial_cell2.06585567
23* MP0001485_abnormal_pinna_reflex2.06049002
24MP0006054_spinal_hemorrhage2.05227423
25MP0000427_abnormal_hair_cycle2.00458405
26MP0003868_abnormal_feces_composition1.97949203
27MP0003136_yellow_coat_color1.94178773
28MP0000778_abnormal_nervous_system1.93407832
29MP0000538_abnormal_urinary_bladder1.87593621
30MP0002272_abnormal_nervous_system1.76762440
31MP0003632_abnormal_nervous_system1.76718704
32MP0001299_abnormal_eye_distance/1.74175711
33MP0000516_abnormal_urinary_system1.73580275
34MP0005367_renal/urinary_system_phenotyp1.73580275
35* MP0001486_abnormal_startle_reflex1.65411611
36MP0005409_darkened_coat_color1.65068351
37MP0002009_preneoplasia1.63939576
38MP0003937_abnormal_limbs/digits/tail_de1.63537549
39MP0003252_abnormal_bile_duct1.61281839
40MP0005623_abnormal_meninges_morphology1.59936202
41MP0002229_neurodegeneration1.59616209
42MP0004043_abnormal_pH_regulation1.56798634
43MP0004134_abnormal_chest_morphology1.54416954
44MP0005365_abnormal_bile_salt1.51638626
45MP0001905_abnormal_dopamine_level1.51464565
46MP0002166_altered_tumor_susceptibility1.51280389
47MP0000762_abnormal_tongue_morphology1.51155704
48MP0005451_abnormal_body_composition1.50394750
49MP0001529_abnormal_vocalization1.49105976
50MP0000604_amyloidosis1.45873764
51MP0004215_abnormal_myocardial_fiber1.44592956
52MP0005410_abnormal_fertilization1.43520797
53MP0003283_abnormal_digestive_organ1.40736527
54MP0003943_abnormal_hepatobiliary_system1.37640353
55MP0002734_abnormal_mechanical_nocicepti1.34803444
56MP0009384_cardiac_valve_regurgitation1.34127993
57MP0004381_abnormal_hair_follicle1.33910817
58MP0000747_muscle_weakness1.33874788
59MP0001879_abnormal_lymphatic_vessel1.33429284
60MP0002876_abnormal_thyroid_physiology1.31958550
61MP0005408_hypopigmentation1.31427714
62MP0005187_abnormal_penis_morphology1.30160179
63MP0003183_abnormal_peptide_metabolism1.29344286
64MP0009780_abnormal_chondrocyte_physiolo1.27267781
65MP0003941_abnormal_skin_development1.27085898
66MP0002064_seizures1.26851765
67MP0004782_abnormal_surfactant_physiolog1.26545341
68MP0004272_abnormal_basement_membrane1.25936415
69MP0000647_abnormal_sebaceous_gland1.25910169
70MP0004147_increased_porphyrin_level1.24875347
71MP0004185_abnormal_adipocyte_glucose1.24065008
72MP0001177_atelectasis1.22392110
73MP0000467_abnormal_esophagus_morphology1.20962912
74MP0008438_abnormal_cutaneous_collagen1.20813314
75MP0002139_abnormal_hepatobiliary_system1.19625762
76MP0002138_abnormal_hepatobiliary_system1.17578591
77MP0005551_abnormal_eye_electrophysiolog1.15297855
78MP0003718_maternal_effect1.15095192
79MP0001873_stomach_inflammation1.13812773
80MP0002295_abnormal_pulmonary_circulatio1.13250527
81MP0005670_abnormal_white_adipose1.13220012
82MP0005646_abnormal_pituitary_gland1.12895642
83MP0004484_altered_response_of1.12244480
84MP0003938_abnormal_ear_development1.11055035
85MP0003631_nervous_system_phenotype1.10519897
86MP0004145_abnormal_muscle_electrophysio1.10116265
87MP0004142_abnormal_muscle_tone1.08490762
88MP0001661_extended_life_span1.07372467
89* MP0002882_abnormal_neuron_morphology1.06586595
90MP0002006_tumorigenesis1.06438214
91MP0002098_abnormal_vibrissa_morphology1.05786857
92MP0003890_abnormal_embryonic-extraembry1.05665781
93MP0001664_abnormal_digestion1.05593006
94MP0005275_abnormal_skin_tensile1.04228585
95MP0000613_abnormal_salivary_gland1.01741832
96MP0002896_abnormal_bone_mineralization1.00110315
97MP0005195_abnormal_posterior_eye0.99265197
98MP0000955_abnormal_spinal_cord0.99023651
99MP0006072_abnormal_retinal_apoptosis0.98924716
100MP0009697_abnormal_copulation0.98593715
101* MP0001963_abnormal_hearing_physiology0.97769251
102MP0000627_abnormal_mammary_gland0.97226998
103MP0003045_fibrosis0.97086040
104MP0002796_impaired_skin_barrier0.96750999
105* MP0002752_abnormal_somatic_nervous0.96354102
106MP0005395_other_phenotype0.96239904
107MP0000579_abnormal_nail_morphology0.95376615
108MP0008004_abnormal_stomach_pH0.94683381
109MP0005381_digestive/alimentary_phenotyp0.94640006
110MP0003453_abnormal_keratinocyte_physiol0.93009989
111MP0004019_abnormal_vitamin_homeostasis0.92659499
112MP0003119_abnormal_digestive_system0.91625329
113MP0001756_abnormal_urination0.90380217
114MP0005423_abnormal_somatic_nervous0.90306514
115MP0002168_other_aberrant_phenotype0.89731736
116MP0003300_gastrointestinal_ulcer0.89196079
117MP0001765_abnormal_ion_homeostasis0.88811319
118MP0009250_abnormal_appendicular_skeleto0.88452238
119MP0001851_eye_inflammation0.86323737
120MP0010368_abnormal_lymphatic_system0.86218276
121MP0002233_abnormal_nose_morphology0.85169180
122* MP0000477_abnormal_intestine_morphology0.84912858
123MP0005388_respiratory_system_phenotype0.84487168
124MP0002133_abnormal_respiratory_system0.84487168
125MP0009046_muscle_twitch0.83956095
126MP0008875_abnormal_xenobiotic_pharmacok0.83427475
127MP0003633_abnormal_nervous_system0.82651208
128MP0001440_abnormal_grooming_behavior0.81747900
129MP0009745_abnormal_behavioral_response0.81388013
130MP0005220_abnormal_exocrine_pancreas0.81205150
131MP0002160_abnormal_reproductive_system0.81021892
132MP0001501_abnormal_sleep_pattern0.80858226
133MP0008260_abnormal_autophagy0.80455154
134MP0000377_abnormal_hair_follicle0.79394951
135* MP0002066_abnormal_motor_capabilities/c0.78040590
136MP0008872_abnormal_physiological_respon0.77517480
137MP0010386_abnormal_urinary_bladder0.75829693
138MP0008775_abnormal_heart_ventricle0.75828638
139MP0002282_abnormal_trachea_morphology0.75173697
140MP0008569_lethality_at_weaning0.74602165
141MP0003866_abnormal_defecation0.74592693
142MP0004036_abnormal_muscle_relaxation0.74291600
143MP0003635_abnormal_synaptic_transmissio0.73395904
144MP0000470_abnormal_stomach_morphology0.72177617
145MP0004264_abnormal_extraembryonic_tissu0.72047045
146MP0010329_abnormal_lipoprotein_level0.71560049
147MP0001970_abnormal_pain_threshold0.70695134
148MP0003936_abnormal_reproductive_system0.70602888
149MP0000003_abnormal_adipose_tissue0.68122289
150MP0005058_abnormal_lysosome_morphology0.67484542
151MP0010307_abnormal_tumor_latency0.67297382
152MP0005253_abnormal_eye_physiology0.66672025
153MP0001340_abnormal_eyelid_morphology0.66224082
154MP0003137_abnormal_impulse_conducting0.66182120
155MP0000432_abnormal_head_morphology0.65648721
156MP0003935_abnormal_craniofacial_develop0.65437497
157MP0004859_abnormal_synaptic_plasticity0.65426764
158MP0005332_abnormal_amino_acid0.64959085
159MP0009643_abnormal_urine_homeostasis0.63796697
160MP0001216_abnormal_epidermal_layer0.62755215
161MP0002067_abnormal_sensory_capabilities0.62398714
162MP0000534_abnormal_ureter_morphology0.62240900
163MP0004084_abnormal_cardiac_muscle0.61741085
164MP0003195_calcinosis0.61009773
165MP0003755_abnormal_palate_morphology0.59111813
166MP0005501_abnormal_skin_physiology0.59108833
167MP0010771_integument_phenotype0.58496039
168MP0000013_abnormal_adipose_tissue0.58311935

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.61548038
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.61548038
3Neurofibrillary tangles (HP:0002185)5.41079726
4Abnormality of the corticospinal tract (HP:0002492)4.78115802
5Sensory axonal neuropathy (HP:0003390)4.77931040
6Parakeratosis (HP:0001036)4.50728114
7Right ventricular cardiomyopathy (HP:0011663)4.40744594
8Peripheral hypomyelination (HP:0007182)4.06422017
9Cerebral inclusion bodies (HP:0100314)3.95447807
10Aplasia involving bones of the extremities (HP:0009825)3.72554474
11Aplasia involving bones of the upper limbs (HP:0009823)3.72554474
12Aplasia of the phalanges of the hand (HP:0009802)3.72554474
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.54580572
14Morphological abnormality of the inner ear (HP:0011390)3.49946989
15Intention tremor (HP:0002080)3.49536696
16Onion bulb formation (HP:0003383)3.48183765
17Insidious onset (HP:0003587)3.47075808
18Termporal pattern (HP:0011008)3.47075808
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.39506601
20Hyperactive renin-angiotensin system (HP:0000841)3.38770733
21Abnormality of the phalanges of the 2nd finger (HP:0009541)3.33157542
22Abnormal biliary tract morphology (HP:0012440)3.31815380
23Alacrima (HP:0000522)3.30455761
24Curly hair (HP:0002212)3.27043669
25Decreased circulating renin level (HP:0003351)3.21899392
26Cerebral hypomyelination (HP:0006808)3.21003886
27Spastic gait (HP:0002064)3.08319070
28Abnormality of cochlea (HP:0000375)3.00147257
29Breast carcinoma (HP:0003002)2.98896427
30Premature skin wrinkling (HP:0100678)2.98252697
31Malnutrition (HP:0004395)2.92093259
32Abnormal auditory evoked potentials (HP:0006958)2.91338749
33Fat malabsorption (HP:0002630)2.85832120
34Intrahepatic cholestasis (HP:0001406)2.84073952
35Congenital ichthyosiform erythroderma (HP:0007431)2.80154160
36Abnormality of proline metabolism (HP:0010907)2.78582083
37Hydroxyprolinuria (HP:0003080)2.78582083
38Anteriorly placed anus (HP:0001545)2.75968645
39Ileus (HP:0002595)2.75359346
40Abnormality of the 2nd finger (HP:0004100)2.74758956
41Abnormality of the middle phalanges of the toes (HP:0010183)2.74453590
42Akinesia (HP:0002304)2.72611233
43Hypoplasia of the uterus (HP:0000013)2.71816177
44Stridor (HP:0010307)2.71272419
45Posterior subcapsular cataract (HP:0007787)2.69348179
46Pili torti (HP:0003777)2.68399149
47Abnormality of the nasal septum (HP:0000419)2.68300904
48Abnormality of renin-angiotensin system (HP:0000847)2.68205520
49Abnormality of the vitamin B12 metabolism (HP:0004341)2.67843772
50Proximal tubulopathy (HP:0000114)2.67243894
51Coronal craniosynostosis (HP:0004440)2.67185911
52Abnormality of vitamin B metabolism (HP:0004340)2.64085074
53Supranuclear gaze palsy (HP:0000605)2.60758439
54Dysmetria (HP:0001310)2.57965560
55Congenital, generalized hypertrichosis (HP:0004540)2.54929613
56Biliary tract neoplasm (HP:0100574)2.52087304
57Decreased lacrimation (HP:0000633)2.51284017
58Esophageal atresia (HP:0002032)2.48548635
59Chin dimple (HP:0010751)2.41315079
60Congenital sensorineural hearing impairment (HP:0008527)2.38665676
61Hypoplasia of the iris (HP:0007676)2.37952614
62Retinal dysplasia (HP:0007973)2.35446033
63Hyperaldosteronism (HP:0000859)2.35179058
64Scanning speech (HP:0002168)2.32817313
65Pigmentary retinal degeneration (HP:0001146)2.32367264
66Hyporeflexia of lower limbs (HP:0002600)2.32253338
67Thickened helices (HP:0000391)2.29196586
68Short hallux (HP:0010109)2.28965448
69Subcapsular cataract (HP:0000523)2.28696766
70Papillary thyroid carcinoma (HP:0002895)2.27446101
71Stenosis of the external auditory canal (HP:0000402)2.26332254
72Increased serum pyruvate (HP:0003542)2.25708013
73Abnormality of glycolysis (HP:0004366)2.25708013
74Abnormal pancreas size (HP:0012094)2.22166427
75Abnormal tarsal ossification (HP:0008369)2.21899926
76Ankle clonus (HP:0011448)2.20158001
77Abnormality of chloride homeostasis (HP:0011422)2.19067308
78Autoamputation (HP:0001218)2.18814502
79Segmental peripheral demyelination/remyelination (HP:0003481)2.18274336
80Hypoplastic pelvis (HP:0008839)2.17990318
81Abnormality of vitamin metabolism (HP:0100508)2.17707683
82Hyperventilation (HP:0002883)2.15988795
83Cupped ear (HP:0000378)2.15249655
84Partial duplication of thumb phalanx (HP:0009944)2.15175428
85Split foot (HP:0001839)2.14103061
86CNS hypomyelination (HP:0003429)2.13182191
87Humeroradial synostosis (HP:0003041)2.13079465
88Synostosis involving the elbow (HP:0003938)2.13079465
89Symphalangism affecting the phalanges of the hand (HP:0009773)2.12458693
90Hamartoma of the eye (HP:0010568)2.12010543
91Hyperkalemia (HP:0002153)2.11507254
92Metabolic alkalosis (HP:0200114)2.10847364
93Woolly hair (HP:0002224)2.08671431
94Infantile muscular hypotonia (HP:0008947)2.08266462
95Cone-rod dystrophy (HP:0000548)2.07933913
96Cerebral hemorrhage (HP:0001342)2.07426880
97Increased circulating renin level (HP:0000848)2.06990973
98Volvulus (HP:0002580)2.06875179
99Muscle hypertrophy of the lower extremities (HP:0008968)2.05899805
100Muscle fiber splitting (HP:0003555)2.05344025
101Absent septum pellucidum (HP:0001331)2.04448609
102Bifid scrotum (HP:0000048)2.03924518
103Hypothermia (HP:0002045)2.02933058
104Aplasia/Hypoplasia of the hallux (HP:0008362)2.02755827
105Hypoplastic nipples (HP:0002557)2.01849346
106Hyperglycinuria (HP:0003108)2.01037473
107Spastic paraparesis (HP:0002313)2.01022722
108Hypomagnesemia (HP:0002917)2.00973314
109Exocrine pancreatic insufficiency (HP:0001738)2.00765720
110Barrel-shaped chest (HP:0001552)1.99859907
111Steatorrhea (HP:0002570)1.98604846
112Abnormality of the renal cortex (HP:0011035)1.94067079
113Leukodystrophy (HP:0002415)1.92064721
114Hypokalemic alkalosis (HP:0001949)1.90932974
115Abnormality of the salivary glands (HP:0010286)1.90400211
116Popliteal pterygium (HP:0009756)1.88126079
117Megalencephaly (HP:0001355)1.86868574
118Bell-shaped thorax (HP:0001591)1.85647181
119Gowers sign (HP:0003391)1.85240109
120Subacute progressive viral hepatitis (HP:0006572)1.85114166
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.84396575
122Chronic diarrhea (HP:0002028)1.84291601
123Chorioretinal atrophy (HP:0000533)1.84261133
124Slow saccadic eye movements (HP:0000514)1.84252910
125Aplasia/hypoplasia of the uterus (HP:0008684)1.84218587
126Neuroendocrine neoplasm (HP:0100634)1.83883532
127Partial duplication of the phalanx of hand (HP:0009999)1.83742327
128Abnormality of potassium homeostasis (HP:0011042)1.83307718
129Difficulty running (HP:0009046)1.82805920
130Midline defect of the nose (HP:0004122)1.82402656
131Arterial tortuosity (HP:0005116)1.81329970
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80870056
133Germ cell neoplasia (HP:0100728)1.80807550
134Abnormality of the 1st metacarpal (HP:0010009)1.80394558
135Uterine neoplasm (HP:0010784)1.80304465
136Lower limb muscle weakness (HP:0007340)1.79325180
137Abnormality of the ischium (HP:0003174)1.79066877
138Foot dorsiflexor weakness (HP:0009027)1.78743141
139Syncope (HP:0001279)1.78216709
140Abnormality of the septum pellucidum (HP:0007375)1.78008663
141Abnormal hair laboratory examination (HP:0003328)1.77564843
142Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77454637
143Abnormal foot bone ossification (HP:0010675)1.77117661
144Clumsiness (HP:0002312)1.76532977
145Decreased motor nerve conduction velocity (HP:0003431)1.76197166
146Conjugated hyperbilirubinemia (HP:0002908)1.75192002
147Hyperglycemia (HP:0003074)1.74296448
148Tracheal stenosis (HP:0002777)1.72689363
149Ulnar bowing (HP:0003031)1.72460708
150Micronodular cirrhosis (HP:0001413)1.71443300
151Stomach cancer (HP:0012126)1.71271640
152Neoplasm of the small intestine (HP:0100833)1.71221079
153Lip pit (HP:0100267)1.71184671
154Buphthalmos (HP:0000557)1.71081363
155Gaze-evoked nystagmus (HP:0000640)1.69054276
156Microglossia (HP:0000171)1.67998660
157Visceral angiomatosis (HP:0100761)1.65831994
158Bowel incontinence (HP:0002607)1.64794885
159Fair hair (HP:0002286)1.64750506
160Renal cortical cysts (HP:0000803)1.64491407
161Spastic tetraparesis (HP:0001285)1.64128936
162White forelock (HP:0002211)1.63442857
163Scapular winging (HP:0003691)1.63441702
164Adrenal hypoplasia (HP:0000835)1.62918308
165Partial agenesis of the corpus callosum (HP:0001338)1.62744593
166Short middle phalanx of finger (HP:0005819)1.62193370
167Exotropia (HP:0000577)1.61624835
168Pheochromocytoma (HP:0002666)1.61323951
169Focal segmental glomerulosclerosis (HP:0000097)1.60970372
170Relative macrocephaly (HP:0004482)1.60358724
171Tetraparesis (HP:0002273)1.60302158
172Bundle branch block (HP:0011710)1.59563222
173Hypokalemia (HP:0002900)1.59454938
174Thyroid carcinoma (HP:0002890)1.59367944
175Abnormal glucose tolerance (HP:0001952)1.57415969
176Rhabdomyosarcoma (HP:0002859)1.55796357
177Tubular atrophy (HP:0000092)1.55406873
178Gastrointestinal carcinoma (HP:0002672)1.54980287
179Malignant gastrointestinal tract tumors (HP:0006749)1.54980287
180Abnormality of serine family amino acid metabolism (HP:0010894)1.53890371
181Abnormality of glycine metabolism (HP:0010895)1.53890371
182Abnormality of monocarboxylic acid metabolism (HP:0010996)1.50842527
183Transitional cell carcinoma of the bladder (HP:0006740)1.50452843
184Ovarian neoplasm (HP:0100615)1.50087396
185Alkalosis (HP:0001948)1.49714062
186Hypobetalipoproteinemia (HP:0003563)1.49685614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* STK394.57906047
2MST44.23835644
3ACVR1B3.84786117
4EPHB13.62226011
5EIF2AK33.15394415
6WNK43.00904328
7BCR2.93901999
8FGFR22.90534886
9MET2.81160513
10LMTK22.69828541
11PKN12.50143763
12MAP3K122.39611081
13PBK2.27377710
14WNK12.26122531
15MAPKAPK52.23735824
16TNIK2.11391128
17LIMK11.98580135
18CDK191.94370234
19* OXSR11.90721361
20STK38L1.83935089
21CSNK1A1L1.82363524
22ROCK21.78320082
23ICK1.74313090
24NEK61.73472817
25CSNK1G31.69165723
26MKNK21.61377416
27BRSK21.58201718
28TRIM281.57598206
29NTRK11.57072477
30ERBB31.49785975
31CSNK1G11.47753282
32CAMK2B1.46975519
33STK241.44928692
34TIE11.42914634
35TAF11.38790270
36FGR1.34508901
37CSNK1G21.30688949
38UHMK11.30208110
39CAMK2D1.29968108
40FRK1.28454100
41LATS11.23027581
42EPHB21.21142285
43TYRO31.18918030
44PAK31.18730352
45MAP3K21.17262548
46TESK21.16606944
47NUAK11.10241236
48CLK11.09535030
49PNCK1.09415706
50EPHA21.09306805
51TRPM71.08874816
52NLK1.03223713
53PAK61.01300106
54AKT31.01142960
55PHKG21.00122779
56PHKG11.00122779
57CAMK2G0.96979439
58PRKCI0.95956594
59CASK0.92461631
60SGK2230.92026961
61SGK4940.92026961
62PIK3CA0.91985107
63PRKCQ0.90757722
64PRPF4B0.87206862
65MAPKAPK30.85317153
66INSRR0.84811075
67FER0.84617386
68DMPK0.84429494
69PRKG20.84004441
70MUSK0.83275887
71EEF2K0.79744641
72DDR20.76105200
73MARK20.75913523
74MAP2K20.75889773
75PRKD10.74877890
76MAPK150.74286317
77RPS6KB20.72692443
78EIF2AK10.71805146
79MELK0.71081169
80CDK50.70899781
81RIPK10.70054890
82SCYL20.69920988
83MYLK0.69866421
84MAP2K10.69592994
85PDGFRB0.69249738
86PLK20.67625766
87PRKAA20.66837956
88STK100.66674095
89BMPR1B0.66223912
90FGFR10.66071891
91PRKCE0.65369178
92CAMK2A0.64737438
93BRD40.64347873
94TSSK60.64021230
95PDPK10.62361762
96ERBB40.62238645
97ROCK10.62111214
98MKNK10.62104729
99EPHA40.57177978
100GSK3A0.57164783
101FYN0.56074414
102CSNK1D0.55292299
103CDK140.52838573
104TTN0.52504533
105OBSCN0.51640474
106DYRK20.51357735
107FGFR30.51169694
108IRAK20.46286489
109MST1R0.46151592
110PAK20.45977353
111WEE10.45584103
112PAK40.45344442
113PDK20.44901463
114GRK10.44867531
115CSNK1A10.44746546
116CAMK1G0.42755974
117CDK150.42466001
118EIF2AK20.42451581
119TGFBR10.42034756
120PRKG10.41858766
121PRKACB0.40398950
122SGK20.38667580
123ZAK0.38483432
124STK30.38355949
125ERBB20.36697204
126INSR0.36523877
127BMPR20.36514889
128RPS6KB10.36220971
129CDK180.35926716
130CDK11A0.35054721
131RPS6KA50.35053433
132STK110.33748967
133MAPK130.33327061
134PLK30.32966890
135PIK3CG0.32804613
136CSNK1E0.32671761
137LRRK20.32607689
138PINK10.32603182
139PTK20.32276233
140KSR20.32109816
141TTK0.30963559
142MAP4K20.30772202
143PRKAA10.30240152
144PAK10.29233550
145AKT20.27498200
146PTK60.26921482
147PRKD30.26572391
148NEK90.26449606
149ABL10.25084944
150MARK10.24720108
151MINK10.24128156
152CHUK0.22525881

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.05885399
2Steroid biosynthesis_Homo sapiens_hsa001004.24267612
3Fatty acid elongation_Homo sapiens_hsa000623.86817473
4Sulfur metabolism_Homo sapiens_hsa009203.22622367
5Ether lipid metabolism_Homo sapiens_hsa005653.08978658
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.06987322
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74379929
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.71962497
9Caffeine metabolism_Homo sapiens_hsa002322.64337633
10Vitamin digestion and absorption_Homo sapiens_hsa049772.38259844
11Fat digestion and absorption_Homo sapiens_hsa049752.26645281
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.25003979
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.15742446
14Sphingolipid metabolism_Homo sapiens_hsa006002.14496569
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08484842
16Tight junction_Homo sapiens_hsa045302.05921097
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.05197391
18Axon guidance_Homo sapiens_hsa043601.94203106
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.90363372
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78004033
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.77321684
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77083959
23Retinol metabolism_Homo sapiens_hsa008301.75123113
24Protein export_Homo sapiens_hsa030601.68451553
25Vitamin B6 metabolism_Homo sapiens_hsa007501.63172939
26Starch and sucrose metabolism_Homo sapiens_hsa005001.55321375
27Nitrogen metabolism_Homo sapiens_hsa009101.55297947
28Bile secretion_Homo sapiens_hsa049761.49704895
29Chemical carcinogenesis_Homo sapiens_hsa052041.45700489
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40950891
31Histidine metabolism_Homo sapiens_hsa003401.39839119
32Linoleic acid metabolism_Homo sapiens_hsa005911.39687825
33Mineral absorption_Homo sapiens_hsa049781.35768215
34Tryptophan metabolism_Homo sapiens_hsa003801.35632871
35ABC transporters_Homo sapiens_hsa020101.34556965
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33270488
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32522543
38Renal cell carcinoma_Homo sapiens_hsa052111.31383318
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26312735
40ECM-receptor interaction_Homo sapiens_hsa045121.26164784
41Fatty acid degradation_Homo sapiens_hsa000711.24467274
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20399430
43Butanoate metabolism_Homo sapiens_hsa006501.13284031
44Oxidative phosphorylation_Homo sapiens_hsa001901.12283965
45Arginine and proline metabolism_Homo sapiens_hsa003301.12141121
46Arginine biosynthesis_Homo sapiens_hsa002201.06838084
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04129685
48Sphingolipid signaling pathway_Homo sapiens_hsa040711.01679917
49Gastric acid secretion_Homo sapiens_hsa049710.97445182
50Glycerolipid metabolism_Homo sapiens_hsa005610.96893725
51Dorso-ventral axis formation_Homo sapiens_hsa043200.95889853
52Serotonergic synapse_Homo sapiens_hsa047260.94815708
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92826021
54Glutamatergic synapse_Homo sapiens_hsa047240.91648904
55Alzheimers disease_Homo sapiens_hsa050100.90748860
56Long-term depression_Homo sapiens_hsa047300.89841882
57Circadian rhythm_Homo sapiens_hsa047100.89332063
58Fatty acid biosynthesis_Homo sapiens_hsa000610.87419348
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.86939986
60Endocytosis_Homo sapiens_hsa041440.86019921
61PPAR signaling pathway_Homo sapiens_hsa033200.85111404
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84919201
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.84854425
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84811561
65Arachidonic acid metabolism_Homo sapiens_hsa005900.84630209
66beta-Alanine metabolism_Homo sapiens_hsa004100.80568830
67Hippo signaling pathway_Homo sapiens_hsa043900.79117449
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79059948
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78756475
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.78081487
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.77897647
72Glutathione metabolism_Homo sapiens_hsa004800.76216248
73ErbB signaling pathway_Homo sapiens_hsa040120.76158789
74Insulin secretion_Homo sapiens_hsa049110.75900461
75GABAergic synapse_Homo sapiens_hsa047270.73619049
76Ras signaling pathway_Homo sapiens_hsa040140.73221345
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72795174
78Peroxisome_Homo sapiens_hsa041460.71414570
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.71098728
80Propanoate metabolism_Homo sapiens_hsa006400.70540608
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69863267
82Fatty acid metabolism_Homo sapiens_hsa012120.69452067
83Protein digestion and absorption_Homo sapiens_hsa049740.68853111
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68006116
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67126195
86* Vibrio cholerae infection_Homo sapiens_hsa051100.66875315
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63493498
88Amphetamine addiction_Homo sapiens_hsa050310.63223011
89Focal adhesion_Homo sapiens_hsa045100.62568685
90Choline metabolism in cancer_Homo sapiens_hsa052310.61292481
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59893451
92* Pancreatic secretion_Homo sapiens_hsa049720.59668842
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57857382
94Selenocompound metabolism_Homo sapiens_hsa004500.57184292
95Prostate cancer_Homo sapiens_hsa052150.56804708
96Hedgehog signaling pathway_Homo sapiens_hsa043400.56646759
97Lysosome_Homo sapiens_hsa041420.56154661
98Renin-angiotensin system_Homo sapiens_hsa046140.55911658
99Inositol phosphate metabolism_Homo sapiens_hsa005620.55769116
100Non-homologous end-joining_Homo sapiens_hsa034500.55046195
101Parkinsons disease_Homo sapiens_hsa050120.54653468
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52973147
103* Salivary secretion_Homo sapiens_hsa049700.52546390
104Collecting duct acid secretion_Homo sapiens_hsa049660.52493544
105Glucagon signaling pathway_Homo sapiens_hsa049220.51856692
106Ovarian steroidogenesis_Homo sapiens_hsa049130.51385574
107Thyroid hormone synthesis_Homo sapiens_hsa049180.51381941
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50587124
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.49448757
110Morphine addiction_Homo sapiens_hsa050320.48369288
111Gap junction_Homo sapiens_hsa045400.47212587
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46324779
113Renin secretion_Homo sapiens_hsa049240.45916396
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45495094
115Wnt signaling pathway_Homo sapiens_hsa043100.45099226
116Basal cell carcinoma_Homo sapiens_hsa052170.44113992
117Cholinergic synapse_Homo sapiens_hsa047250.44070621
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43520096
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42889356
120Cardiac muscle contraction_Homo sapiens_hsa042600.42379788
121Insulin resistance_Homo sapiens_hsa049310.41018043
122Taste transduction_Homo sapiens_hsa047420.40896171
123Endometrial cancer_Homo sapiens_hsa052130.40730474
124Thyroid cancer_Homo sapiens_hsa052160.39557336
125Cocaine addiction_Homo sapiens_hsa050300.39122513
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38094281
127Rap1 signaling pathway_Homo sapiens_hsa040150.36526244
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36384403
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35810721
130Proteoglycans in cancer_Homo sapiens_hsa052050.34981074
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34972417
132Dopaminergic synapse_Homo sapiens_hsa047280.34911530
133TGF-beta signaling pathway_Homo sapiens_hsa043500.34557687
134Rheumatoid arthritis_Homo sapiens_hsa053230.33907238
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33273898
136Adherens junction_Homo sapiens_hsa045200.32685233
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32661472
138Phototransduction_Homo sapiens_hsa047440.32040156
139Metabolic pathways_Homo sapiens_hsa011000.31453263
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31398106
141Autoimmune thyroid disease_Homo sapiens_hsa053200.31215052
142Lysine degradation_Homo sapiens_hsa003100.30847739
143Folate biosynthesis_Homo sapiens_hsa007900.30669023
144Oocyte meiosis_Homo sapiens_hsa041140.29466629
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28936018
146Pyruvate metabolism_Homo sapiens_hsa006200.28351543
147cAMP signaling pathway_Homo sapiens_hsa040240.28345999
148Basal transcription factors_Homo sapiens_hsa030220.28101629
149Circadian entrainment_Homo sapiens_hsa047130.28092543

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