SLC10A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hair cycle (GO:0042633)7.93826515
2molting cycle (GO:0042303)7.93826515
3epidermal cell differentiation (GO:0009913)7.82994910
4positive regulation of cellular amide metabolic process (GO:0034250)7.77196196
5keratinocyte proliferation (GO:0043616)7.24930204
6epidermis development (GO:0008544)6.53992018
7cellular response to nitric oxide (GO:0071732)6.30694150
8regulation of transforming growth factor beta1 production (GO:0032908)6.29792804
9positive regulation of glomerulus development (GO:0090193)5.75166728
10long-chain fatty acid biosynthetic process (GO:0042759)5.73599369
11positive regulation of interleukin-8 secretion (GO:2000484)5.63747627
12negative regulation of complement activation (GO:0045916)5.59653906
13phosphatidylserine acyl-chain remodeling (GO:0036150)5.14890214
14response to nitric oxide (GO:0071731)5.02137646
15lipoxygenase pathway (GO:0019372)4.98500436
16phosphatidylinositol acyl-chain remodeling (GO:0036149)4.96204417
17detection of bacterium (GO:0016045)4.92951327
18defense response to Gram-negative bacterium (GO:0050829)4.80854894
19negative regulation of protein activation cascade (GO:2000258)4.77402852
20lymph vessel development (GO:0001945)4.77162177
21keratinization (GO:0031424)4.74749228
22linoleic acid metabolic process (GO:0043651)4.73167161
23intermediate filament organization (GO:0045109)4.71019463
24positive regulation of p38MAPK cascade (GO:1900745)4.69030016
25positive regulation of humoral immune response (GO:0002922)4.65094292
26cellular response to reactive nitrogen species (GO:1902170)4.62613824
27keratan sulfate catabolic process (GO:0042340)4.59641559
28regulation of cell proliferation involved in kidney development (GO:1901722)4.55238173
29phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.50583228
30intermediate filament cytoskeleton organization (GO:0045104)4.47340003
31detection of other organism (GO:0098543)4.44277153
32phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.36336155
33intermediate filament-based process (GO:0045103)4.32492232
34blood vessel maturation (GO:0001955)4.30867470
35regulation of endothelial cell differentiation (GO:0045601)4.28585799
36retina vasculature morphogenesis in camera-type eye (GO:0061299)4.27325803
37defense response to fungus (GO:0050832)4.21781750
38regulation of natural killer cell differentiation (GO:0032823)4.17280537
39negative regulation of interferon-gamma production (GO:0032689)4.15403561
40opsonization (GO:0008228)4.11957533
41ectoderm development (GO:0007398)4.00891941
42surfactant homeostasis (GO:0043129)3.99149207
43positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.94658188
44regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.94658188
45positive regulation of epidermis development (GO:0045684)3.93853417
46peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.90561169
47regulation of interleukin-8 secretion (GO:2000482)3.89908835
48cellular response to cadmium ion (GO:0071276)3.87407244
49positive regulation of transforming growth factor beta production (GO:0071636)3.81518651
50phosphatidylcholine acyl-chain remodeling (GO:0036151)3.80115581
51positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.78745828
52establishment of skin barrier (GO:0061436)3.77011414
53regulation of cellular amide metabolic process (GO:0034248)3.75322295
54regulation of complement activation (GO:0030449)3.75314135
55regulation of integrin-mediated signaling pathway (GO:2001044)3.73637470
56positive regulation of cholesterol efflux (GO:0010875)3.71675091
57peptide cross-linking (GO:0018149)3.71004612
58endothelial cell morphogenesis (GO:0001886)3.69092178
59positive regulation of endothelial cell differentiation (GO:0045603)3.67962070
60positive regulation of epidermal cell differentiation (GO:0045606)3.67017599
61skin morphogenesis (GO:0043589)3.65367976
62negative regulation of interleukin-17 production (GO:0032700)3.63813661
63regulation of glomerulus development (GO:0090192)3.62758404
64antimicrobial humoral response (GO:0019730)3.61673538
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.60487872
66myoblast migration (GO:0051451)3.60403293
67regulation of p38MAPK cascade (GO:1900744)3.55740959
68hemidesmosome assembly (GO:0031581)3.55381281
69regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.50685724
70regulation of protein activation cascade (GO:2000257)3.45083196
71vascular endothelial growth factor signaling pathway (GO:0038084)3.44267514
72peripheral nervous system axon ensheathment (GO:0032292)3.43251029
73myelination in peripheral nervous system (GO:0022011)3.43251029
74pericardium development (GO:0060039)3.41357618
75endothelial cell proliferation (GO:0001935)3.41059438
76negative regulation of humoral immune response (GO:0002921)3.40316981
77regulation of vasculogenesis (GO:2001212)3.39510078
78growth hormone secretion (GO:0030252)3.38886233
79regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.38272286
80basement membrane organization (GO:0071711)3.34668754
81positive regulation of macrophage cytokine production (GO:0060907)3.34061113
82regulation of macrophage cytokine production (GO:0010935)3.33306909
83positive regulation of keratinocyte differentiation (GO:0045618)3.33265301
84regulation of water loss via skin (GO:0033561)3.32080630
85positive regulation of T-helper 1 type immune response (GO:0002827)3.31062713
86fatty acid elongation (GO:0030497)3.29461645
87positive regulation of cholesterol transport (GO:0032376)3.29461591
88positive regulation of sterol transport (GO:0032373)3.29461591
89negative regulation of stress fiber assembly (GO:0051497)3.29253973
90growth hormone receptor signaling pathway (GO:0060396)3.27279614
91UDP-N-acetylglucosamine metabolic process (GO:0006047)3.24811405
92lymphangiogenesis (GO:0001946)3.24657934
93positive regulation of Cdc42 GTPase activity (GO:0043089)3.23521811
94complement activation, alternative pathway (GO:0006957)3.22623035
95keratinocyte development (GO:0003334)3.20132224
96activation of MAPKKK activity (GO:0000185)3.18742841
97phosphatidylserine metabolic process (GO:0006658)3.18290080
98epithelium development (GO:0060429)3.18223303
99ovulation from ovarian follicle (GO:0001542)3.16350908
100extracellular matrix assembly (GO:0085029)3.15817158
101adhesion of symbiont to host (GO:0044406)3.15649090
102collagen fibril organization (GO:0030199)3.14930602
103ventricular cardiac muscle cell development (GO:0055015)3.11381710
104desmosome organization (GO:0002934)3.04112079
105establishment of tissue polarity (GO:0007164)3.03216453
106establishment of planar polarity (GO:0001736)3.03216453
107transcytosis (GO:0045056)3.02747920
108ceramide biosynthetic process (GO:0046513)3.02622758
109radial glial cell differentiation (GO:0060019)3.00450586
110positive regulation of vasculogenesis (GO:2001214)3.00449600
111fibroblast migration (GO:0010761)3.00046404
112cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.96273857
113regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.95901334
114water homeostasis (GO:0030104)2.95493577
115chemical homeostasis within a tissue (GO:0048875)2.94069138
116epithelial cell-cell adhesion (GO:0090136)2.92940050
117bundle of His cell to Purkinje myocyte communication (GO:0086069)2.92394595
118sphingosine metabolic process (GO:0006670)2.89902510
119low-density lipoprotein particle clearance (GO:0034383)2.88854590
120response to fungus (GO:0009620)2.86886492
121extracellular fibril organization (GO:0043206)2.86553818
122cellular response to arsenic-containing substance (GO:0071243)2.86375879
123homocysteine metabolic process (GO:0050667)2.85666538
124negative regulation of keratinocyte proliferation (GO:0010839)2.84915717
125regulation of cardioblast differentiation (GO:0051890)2.84797448
126regulation of hair cycle (GO:0042634)2.84529394
127atrioventricular valve morphogenesis (GO:0003181)2.83357917
128regulation of epidermis development (GO:0045682)2.83308346
129fibrinolysis (GO:0042730)2.81652218
130negative regulation of Rho protein signal transduction (GO:0035024)2.81299529
131skeletal muscle adaptation (GO:0043501)2.81251566
132regulation of keratinocyte differentiation (GO:0045616)2.81093386
133phagocytosis, recognition (GO:0006910)2.79752096
134endothelial cell differentiation (GO:0045446)2.77864808
135phospholipid efflux (GO:0033700)2.77785519
136gap junction assembly (GO:0016264)2.77054602
137glomerular filtration (GO:0003094)2.76527066
138regulation of neuron projection regeneration (GO:0070570)2.74760177
139regulation of axon regeneration (GO:0048679)2.74760177
140negative regulation of lipid storage (GO:0010888)2.72213793
141branching involved in labyrinthine layer morphogenesis (GO:0060670)2.70919692
142regulation of transforming growth factor beta production (GO:0071634)2.70049655
143glomerular basement membrane development (GO:0032836)2.69293351
144cellular response to growth hormone stimulus (GO:0071378)2.68442228
145alditol phosphate metabolic process (GO:0052646)2.67862061
146renal filtration (GO:0097205)2.66136254
147regulation of protein localization to cell surface (GO:2000008)2.65323611
148negative regulation of protein autophosphorylation (GO:0031953)2.64593498
149regulation of cholesterol homeostasis (GO:2000188)2.64206909
150regulation of sequestering of triglyceride (GO:0010889)2.63751808
151virion attachment to host cell (GO:0019062)2.62057252
152adhesion of symbiont to host cell (GO:0044650)2.62057252
153multicellular organismal water homeostasis (GO:0050891)2.60028050
154regulation of transforming growth factor beta2 production (GO:0032909)2.57064101
155interleukin-6-mediated signaling pathway (GO:0070102)2.56756574
156regulation of collagen biosynthetic process (GO:0032965)2.56122535
157muscle cell migration (GO:0014812)2.55790486
158nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.55180634
159detection of molecule of bacterial origin (GO:0032490)2.51588754
160fibril organization (GO:0097435)2.51367732
161fatty acid transmembrane transport (GO:1902001)2.50291381
162regulation of MHC class I biosynthetic process (GO:0045343)2.48064315
163positive regulation of response to biotic stimulus (GO:0002833)2.47397704
164regulation of ruffle assembly (GO:1900027)2.46665512
165regulation of endothelial cell chemotaxis (GO:2001026)2.46568628
166venous blood vessel morphogenesis (GO:0048845)2.46290127
167ventricular cardiac muscle cell action potential (GO:0086005)2.45726762
168dendritic cell migration (GO:0036336)2.45546119
169endothelium development (GO:0003158)2.43364742
170keratinocyte differentiation (GO:0030216)2.43049354
171regulation of epidermal cell differentiation (GO:0045604)2.42093369
172diol metabolic process (GO:0034311)2.41868569
173planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41234806
174cellular response to ATP (GO:0071318)2.41208856
175detection of external biotic stimulus (GO:0098581)2.40741214
176endothelial cell chemotaxis (GO:0035767)2.39708230
177regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.39407658
178regulation of T-helper 1 type immune response (GO:0002825)2.39238075
179sequestering of extracellular ligand from receptor (GO:0035581)2.38775360
180eyelid development in camera-type eye (GO:0061029)2.38064887
181positive regulation of meiotic cell cycle (GO:0051446)2.36627838
182natural killer cell activation involved in immune response (GO:0002323)2.32962913
183phosphatidic acid biosynthetic process (GO:0006654)2.31946385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.64190688
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.01975661
3CLOCK_20551151_ChIP-Seq_293T_Human3.47141526
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.45683021
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.18773100
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.18171711
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.97569143
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.94453816
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.83849840
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.83659089
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.68543658
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60330112
13CJUN_26792858_Chip-Seq_BT549_Human2.49778506
14GATA2_21666600_ChIP-Seq_HMVEC_Human2.49298809
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.45149763
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38154278
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.21946755
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.16659953
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.11940068
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96911048
21CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.94155529
22SALL4_18804426_ChIP-ChIP_XEN_Mouse1.92263844
23CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.87258567
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.84854724
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83317997
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.83140023
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80372046
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77227815
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71984940
30SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71984940
31SOX2_20726797_ChIP-Seq_SW620_Human1.70085432
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68329818
33JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66068200
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65934346
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.58816230
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.57571915
37* TP63_22573176_ChIP-Seq_HFKS_Human1.56967163
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.56801400
39JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55062408
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53962029
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51357719
42GATA1_22025678_ChIP-Seq_K562_Human1.44943941
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43324044
44* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41845325
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39877807
46CTCF_27219007_Chip-Seq_Bcells_Human1.37372600
47GATA6_21074721_ChIP-Seq_CACO-2_Human1.37278240
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35587900
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.33307651
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.33195342
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.33195342
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33037325
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.31657419
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31574358
55P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30404006
56* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30391243
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.29919589
58* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29646802
59EGR1_19032775_ChIP-ChIP_M12_Human1.27596948
60ATF3_27146783_Chip-Seq_COLON_Human1.27366229
61BCAT_22108803_ChIP-Seq_LS180_Human1.26825188
62PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.26494036
63TP53_18474530_ChIP-ChIP_U2OS_Human1.24958236
64BRD4_25478319_ChIP-Seq_HGPS_Human1.22393483
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20403144
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20403144
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15325790
68* TP63_23658742_ChIP-Seq_EP156T_Human1.14733337
69RXR_22108803_ChIP-Seq_LS180_Human1.14046147
70* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13701942
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08834215
72SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07078794
73PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.05950907
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04568759
75RACK7_27058665_Chip-Seq_MCF-7_Human1.01534892
76TCF4_18268006_ChIP-ChIP_LS174T_Human1.00902225
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00795083
78* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00128532
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99427642
80GATA3_24758297_ChIP-Seq_MCF-7_Human0.99326939
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99069288
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99016210
83KLF5_25053715_ChIP-Seq_YYC3_Human0.98032327
84SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96937574
85NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96385568
86PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95445517
87KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94267991
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93494203
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92302731
90* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90700283
91AR_21572438_ChIP-Seq_LNCaP_Human0.90634565
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90492108
93CDX2_22108803_ChIP-Seq_LS180_Human0.90257617
94ERG_20517297_ChIP-Seq_VCAP_Human0.88379617
95PIAS1_25552417_ChIP-Seq_VCAP_Human0.87577783
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87563323
97CTCF_20526341_ChIP-Seq_ESCs_Human0.87252451
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87116549
99P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86659419
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86358445
101P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85903845
102GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84694308
103* SMC4_20622854_ChIP-Seq_HELA_Human0.84301456
104MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.84174273
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83463462
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83284710
107KDM2B_26808549_Chip-Seq_K562_Human0.82691844
108AHR_22903824_ChIP-Seq_MCF-7_Human0.82289045
109RBPJ_21746931_ChIP-Seq_IB4_Human0.81637922
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79654373
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.79590740
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79344783
113CSB_26484114_Chip-Seq_FIBROBLAST_Human0.78326630
114GATA4_25053715_ChIP-Seq_YYC3_Human0.77729348
115* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76938826
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76684160
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.76510092
118HNFA_21074721_ChIP-Seq_CACO-2_Human0.76098549
119P53_21459846_ChIP-Seq_SAOS-2_Human0.75370245
120* RUNX1_27514584_Chip-Seq_MCF-7_Human0.75331972
121LXR_22292898_ChIP-Seq_THP-1_Human0.74493298
122* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74370907
123ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74267053
124VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74129441
125TBL1_22424771_ChIP-Seq_293T_Human0.74013050
126KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73498457
127KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.73498457
128KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73498457
129AR_21909140_ChIP-Seq_LNCAP_Human0.73367316
130TP53_16413492_ChIP-PET_HCT116_Human0.72627459
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72487339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.48075345
2MP0005275_abnormal_skin_tensile6.42121963
3MP0008438_abnormal_cutaneous_collagen6.25456838
4MP0005503_abnormal_tendon_morphology4.56583352
5MP0003724_increased_susceptibility_to3.45111834
6MP0003705_abnormal_hypodermis_morpholog3.37306151
7MP0010368_abnormal_lymphatic_system3.35902505
8MP0004272_abnormal_basement_membrane3.02051922
9MP0004381_abnormal_hair_follicle2.68750894
10MP0001958_emphysema2.67291366
11MP0002796_impaired_skin_barrier2.63517840
12MP0002060_abnormal_skin_morphology2.58309573
13MP0002098_abnormal_vibrissa_morphology2.40046873
14MP0001879_abnormal_lymphatic_vessel2.35160257
15MP0000467_abnormal_esophagus_morphology2.34518332
16MP0002254_reproductive_system_inflammat2.25391533
17MP0003566_abnormal_cell_adhesion2.10330962
18MP0005257_abnormal_intraocular_pressure2.03394173
19MP0003011_delayed_dark_adaptation2.02464230
20MP0000377_abnormal_hair_follicle1.95518256
21MP0000579_abnormal_nail_morphology1.91930020
22MP0000343_altered_response_to1.81670618
23MP0003950_abnormal_plasma_membrane1.80915985
24MP0002877_abnormal_melanocyte_morpholog1.78643874
25MP0001542_abnormal_bone_strength1.76029037
26MP0004185_abnormal_adipocyte_glucose1.75608291
27MP0002108_abnormal_muscle_morphology1.72560293
28MP0003279_aneurysm1.71610176
29MP0000762_abnormal_tongue_morphology1.70482798
30MP0000750_abnormal_muscle_regeneration1.68538698
31MP0005451_abnormal_body_composition1.66619038
32MP0005508_abnormal_skeleton_morphology1.64885053
33MP0005670_abnormal_white_adipose1.63784336
34MP0003941_abnormal_skin_development1.63323032
35MP0000566_synostosis1.54134549
36MP0005409_darkened_coat_color1.54085559
37MP0005377_hearing/vestibular/ear_phenot1.52033850
38MP0003878_abnormal_ear_physiology1.52033850
39MP0005023_abnormal_wound_healing1.50843324
40MP0002295_abnormal_pulmonary_circulatio1.48960557
41MP0003828_pulmonary_edema1.46802999
42MP0000427_abnormal_hair_cycle1.45251427
43MP0000751_myopathy1.45043715
44MP0001851_eye_inflammation1.44860961
45MP0000767_abnormal_smooth_muscle1.41070856
46MP0006054_spinal_hemorrhage1.40733601
47MP0003191_abnormal_cellular_cholesterol1.40010387
48MP0005501_abnormal_skin_physiology1.32123284
49MP0010771_integument_phenotype1.27243921
50MP0000367_abnormal_coat/_hair1.26048977
51MP0000383_abnormal_hair_follicle1.24248098
52MP0004782_abnormal_surfactant_physiolog1.23422286
53MP0009053_abnormal_anal_canal1.21802023
54MP0001243_abnormal_dermal_layer1.20834583
55MP0000749_muscle_degeneration1.16755649
56MP0010030_abnormal_orbit_morphology1.14557764
57MP0001191_abnormal_skin_condition1.12089513
58MP0004885_abnormal_endolymph1.12054926
59MP0001986_abnormal_taste_sensitivity1.11582910
60MP0005666_abnormal_adipose_tissue1.09907015
61MP0003091_abnormal_cell_migration1.09088646
62MP0003453_abnormal_keratinocyte_physiol1.08962321
63MP0001881_abnormal_mammary_gland1.07022530
64MP0005388_respiratory_system_phenotype1.06542507
65MP0002133_abnormal_respiratory_system1.06542507
66MP0001661_extended_life_span1.05801010
67MP0005165_increased_susceptibility_to1.05552566
68MP0001188_hyperpigmentation1.05403177
69MP0005164_abnormal_response_to1.05052909
70MP0001216_abnormal_epidermal_layer0.99612161
71MP0000733_abnormal_muscle_development0.98671950
72MP0004510_myositis0.97166591
73MP0004264_abnormal_extraembryonic_tissu0.96777005
74MP0009379_abnormal_foot_pigmentation0.95975845
75MP0005390_skeleton_phenotype0.95955095
76MP0006138_congestive_heart_failure0.95241565
77MP0003718_maternal_effect0.94474256
78MP0000013_abnormal_adipose_tissue0.93044454
79MP0001533_abnormal_skeleton_physiology0.89845326
80MP0005375_adipose_tissue_phenotype0.87207719
81MP0001346_abnormal_lacrimal_gland0.86001269
82MP0005595_abnormal_vascular_smooth0.85957116
83MP0004883_abnormal_blood_vessel0.85555581
84MP0005076_abnormal_cell_differentiation0.85225593
85MP0005330_cardiomyopathy0.85200820
86MP0002933_joint_inflammation0.85097985
87MP0010678_abnormal_skin_adnexa0.84222272
88MP0004084_abnormal_cardiac_muscle0.82722251
89MP0009931_abnormal_skin_appearance0.81728723
90MP0004947_skin_inflammation0.80843712
91MP0001784_abnormal_fluid_regulation0.80538420
92MP0003448_altered_tumor_morphology0.80109988
93MP0002234_abnormal_pharynx_morphology0.79149909
94MP0005369_muscle_phenotype0.78023277
95MP0004858_abnormal_nervous_system0.77497173
96MP0009384_cardiac_valve_regurgitation0.76711626
97MP0001544_abnormal_cardiovascular_syste0.76340843
98MP0005385_cardiovascular_system_phenoty0.76340843
99MP0000647_abnormal_sebaceous_gland0.75773463
100MP0000249_abnormal_blood_vessel0.74620225
101MP0005397_hematopoietic_system_phenotyp0.74384956
102MP0001545_abnormal_hematopoietic_system0.74384956
103MP0000003_abnormal_adipose_tissue0.73975411
104MP0008004_abnormal_stomach_pH0.73323769
105MP0002972_abnormal_cardiac_muscle0.73042837
106MP0008775_abnormal_heart_ventricle0.72673813
107MP0004036_abnormal_muscle_relaxation0.72634897
108MP0002138_abnormal_hepatobiliary_system0.72315907
109MP0004087_abnormal_muscle_fiber0.72059626
110MP0000627_abnormal_mammary_gland0.71994504
111MP0001614_abnormal_blood_vessel0.71777395
112MP0000465_gastrointestinal_hemorrhage0.71181944
113MP0001177_atelectasis0.70663656
114MP0002971_abnormal_brown_adipose0.69943385
115MP0002128_abnormal_blood_circulation0.69078282
116MP0001756_abnormal_urination0.68045946
117MP0005620_abnormal_muscle_contractility0.66824187
118MP0004130_abnormal_muscle_cell0.65669772
119MP0003045_fibrosis0.65198057
120MP0003303_peritoneal_inflammation0.64897294
121MP0005395_other_phenotype0.64442602
122MP0010352_gastrointestinal_tract_polyps0.64342047
123MP0005410_abnormal_fertilization0.59709734
124MP0002095_abnormal_skin_pigmentation0.49701180
125MP0009840_abnormal_foam_cell0.46943643
126MP0002282_abnormal_trachea_morphology0.45140190
127MP0001340_abnormal_eyelid_morphology0.43838094
128MP0009780_abnormal_chondrocyte_physiolo0.39802001
129MP0001299_abnormal_eye_distance/0.38866690
130MP0004043_abnormal_pH_regulation0.38762491
131MP0008260_abnormal_autophagy0.37714621
132MP0003221_abnormal_cardiomyocyte_apopto0.37345829
133MP0002177_abnormal_outer_ear0.36985663
134MP0001502_abnormal_circadian_rhythm0.36861559
135MP0003656_abnormal_erythrocyte_physiolo0.36590655
136MP0003755_abnormal_palate_morphology0.35320611
137MP0002136_abnormal_kidney_physiology0.30033804
138MP0004484_altered_response_of0.29076940
139MP0009115_abnormal_fat_cell0.28127445
140MP0000015_abnormal_ear_pigmentation0.22928624
141MP0001984_abnormal_olfaction0.22692328
142MP0003315_abnormal_perineum_morphology0.20958118
143MP0003638_abnormal_response/metabolism_0.20149527

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.03897400
2Congenital ichthyosiform erythroderma (HP:0007431)8.02094115
3Parakeratosis (HP:0001036)7.36073190
4Oral leukoplakia (HP:0002745)7.01950627
5Erythroderma (HP:0001019)6.83762280
6Premature rupture of membranes (HP:0001788)6.30740238
7Onycholysis (HP:0001806)5.20394324
8Corneal erosion (HP:0200020)5.01609818
9Increased connective tissue (HP:0009025)4.86573808
10Broad metatarsal (HP:0001783)4.83342999
11Protrusio acetabuli (HP:0003179)4.68077562
12Palmoplantar keratoderma (HP:0000982)4.59973944
13Ankle contracture (HP:0006466)4.52270741
14Ectropion (HP:0000656)4.51099828
15Wrist flexion contracture (HP:0001239)4.41203504
16Muscle fiber splitting (HP:0003555)4.24816960
17Fragile nails (HP:0001808)4.20379334
18Lip pit (HP:0100267)4.11199052
19Hypohidrosis (HP:0000966)4.09060313
20Gangrene (HP:0100758)3.89986116
21Nail dystrophy (HP:0008404)3.86990704
22Abnormality of the axillary hair (HP:0100134)3.73999758
23Abnormality of secondary sexual hair (HP:0009888)3.73999758
24Aortic dissection (HP:0002647)3.72258206
25Spinal rigidity (HP:0003306)3.59020534
26Right ventricular cardiomyopathy (HP:0011663)3.44908663
27Abnormal blistering of the skin (HP:0008066)3.43135213
28Increased IgE level (HP:0003212)3.40179326
29Polycythemia (HP:0001901)3.31843256
30Hematochezia (HP:0002573)3.30282418
31Follicular hyperkeratosis (HP:0007502)3.29812701
32Natal tooth (HP:0000695)3.19672261
33Systemic lupus erythematosus (HP:0002725)3.19217444
34Shallow orbits (HP:0000586)3.17009426
35Short nail (HP:0001799)3.16566367
36Type 1 muscle fiber predominance (HP:0003803)3.13581355
37Pruritus (HP:0000989)3.11040575
38Laryngomalacia (HP:0001601)3.09593870
39Alopecia of scalp (HP:0002293)3.09329096
40Abnormality of the salivary glands (HP:0010286)3.05772269
41Sparse scalp hair (HP:0002209)2.99931851
42Woolly hair (HP:0002224)2.98902022
43Complement deficiency (HP:0004431)2.90406659
44Hyperhidrosis (HP:0000975)2.85967193
45Pustule (HP:0200039)2.84927859
46Osteolytic defects of the hand bones (HP:0009699)2.84544481
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.84544481
48Round ear (HP:0100830)2.83206628
49Abnormality of complement system (HP:0005339)2.77257578
50Abnormal delivery (HP:0001787)2.75899562
51Soft skin (HP:0000977)2.75101364
52Aortic aneurysm (HP:0004942)2.74879144
53Cerebral aneurysm (HP:0004944)2.73015218
54Distal lower limb muscle weakness (HP:0009053)2.72270643
55Rectal prolapse (HP:0002035)2.69649279
56Milia (HP:0001056)2.69049515
57Difficulty climbing stairs (HP:0003551)2.67674138
58Acanthosis nigricans (HP:0000956)2.65536040
59Amyloidosis (HP:0011034)2.60100888
60Absent eyelashes (HP:0000561)2.59104632
61Advanced eruption of teeth (HP:0006288)2.49213952
62Hypotrichosis (HP:0001006)2.49178470
63Dehydration (HP:0001944)2.47306200
64Venous abnormality (HP:0002624)2.46182424
65Cervical subluxation (HP:0003308)2.45547159
66Spontaneous hematomas (HP:0007420)2.43380714
67Mildly elevated creatine phosphokinase (HP:0008180)2.42008332
68Camptodactyly of toe (HP:0001836)2.41944582
69Conjunctival hamartoma (HP:0100780)2.41515673
70Axonal loss (HP:0003447)2.41005927
71Prostate neoplasm (HP:0100787)2.40674738
72Pulmonary artery stenosis (HP:0004415)2.40431019
73Sparse eyelashes (HP:0000653)2.39917601
74Short hallux (HP:0010109)2.33752917
75Reduced subcutaneous adipose tissue (HP:0003758)2.33113991
76Hypoalphalipoproteinemia (HP:0003233)2.33052229
77Distal lower limb amyotrophy (HP:0008944)2.32405176
78Furrowed tongue (HP:0000221)2.30271143
79Hyporeflexia of lower limbs (HP:0002600)2.28960634
80Mitral valve prolapse (HP:0001634)2.27751300
81Patent foramen ovale (HP:0001655)2.25904514
82Corneal dystrophy (HP:0001131)2.25639271
83Esophageal varix (HP:0002040)2.24863794
84Ventricular tachycardia (HP:0004756)2.24593399
85Aplasia involving bones of the extremities (HP:0009825)2.24419415
86Aplasia involving bones of the upper limbs (HP:0009823)2.24419415
87Aplasia of the phalanges of the hand (HP:0009802)2.24419415
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24134963
89Atrophic scars (HP:0001075)2.22297654
90Anonychia (HP:0001798)2.21702384
91Erythema (HP:0010783)2.19907496
92Arterial tortuosity (HP:0005116)2.19224761
93Myocardial infarction (HP:0001658)2.19096733
94Vascular tortuosity (HP:0004948)2.18959921
95Interstitial pulmonary disease (HP:0006530)2.18812447
96Bronchomalacia (HP:0002780)2.18002622
97Eczematoid dermatitis (HP:0000976)2.16107416
98Aplasia/Hypoplasia of the hallux (HP:0008362)2.12997011
99Fragile skin (HP:0001030)2.11659559
100Dilatation of the ascending aorta (HP:0005111)2.10768442
101Spondylolisthesis (HP:0003302)2.10278936
102Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.09135071
103Absent hair (HP:0002298)2.07294440
104Striae distensae (HP:0001065)2.05782990
105Slender build (HP:0001533)2.05253208
106Insulin-resistant diabetes mellitus (HP:0000831)2.01628003
107Areflexia of lower limbs (HP:0002522)2.00720481
108Vertebral compression fractures (HP:0002953)2.00700733
109Deep venous thrombosis (HP:0002625)1.99594589
110Segmental peripheral demyelination/remyelination (HP:0003481)1.99314866
111Decreased subcutaneous fat (HP:0001002)1.98393796
112Ridged nail (HP:0001807)1.98244821
113Conjunctival telangiectasia (HP:0000524)1.96992641
114Palmoplantar hyperkeratosis (HP:0000972)1.96853850
115Hypergammaglobulinemia (HP:0010702)1.95820246
116Venous insufficiency (HP:0005293)1.95011653
117Popliteal pterygium (HP:0009756)1.94385381
118Pili torti (HP:0003777)1.93880446
119Thick nail (HP:0001805)1.93609321
120Abnormality of the calf musculature (HP:0001430)1.92893073
121Peritonitis (HP:0002586)1.92657068
122Muscle fiber inclusion bodies (HP:0100299)1.92587779
123Wormian bones (HP:0002645)1.92424489
124Knee flexion contracture (HP:0006380)1.91564331
125Stomach cancer (HP:0012126)1.90603017
126Abnormality of nail color (HP:0100643)1.89881532
127Aneurysm (HP:0002617)1.89496542
128Mesangial abnormality (HP:0001966)1.89105768
129Difficulty running (HP:0009046)1.88212715
130Blepharitis (HP:0000498)1.87622254
131Plantar hyperkeratosis (HP:0007556)1.86398434
132Hyperextensible skin (HP:0000974)1.85489178
133Hypoplastic labia majora (HP:0000059)1.84820228
134Lack of skin elasticity (HP:0100679)1.83504529
135Myotonia (HP:0002486)1.82686906
136Oligomenorrhea (HP:0000876)1.82247224
137Abnormality of the nasal mucosa (HP:0000433)1.81101342
138Carious teeth (HP:0000670)1.78525347
139Mitral stenosis (HP:0001718)1.77950600
140Flexion contracture of toe (HP:0005830)1.77274395
141Joint contractures involving the joints of the feet (HP:0100492)1.77274395
142Palmar hyperkeratosis (HP:0010765)1.75923351
143Elbow flexion contracture (HP:0002987)1.75689813
144Neck muscle weakness (HP:0000467)1.75333722
145Multifactorial inheritance (HP:0001426)1.73242032
146Dry skin (HP:0000958)1.68179043
147Abnormality of the labia majora (HP:0012881)1.67887731
148Sepsis (HP:0100806)1.65536417
149Amniotic constriction ring (HP:0009775)1.64423665
150Abnormality of placental membranes (HP:0011409)1.64423665
151Skin ulcer (HP:0200042)1.64325989
152Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.63868678
153Abnormal hair laboratory examination (HP:0003328)1.63587646
154Hamartoma of the eye (HP:0010568)1.62978132
155Verrucae (HP:0200043)1.61603189
156Papilloma (HP:0012740)1.61603189
157Dry hair (HP:0011359)1.55355637
158Autoamputation (HP:0001218)1.54696995
159Brittle hair (HP:0002299)1.53165185
160Paralysis (HP:0003470)1.52347485
161Abnormality of the fingernails (HP:0001231)1.52046030
162Curly hair (HP:0002212)1.49104257
163Epidermoid cyst (HP:0200040)1.42059809
164Sudden death (HP:0001699)1.37615576
165Abnormal auditory evoked potentials (HP:0006958)1.36748536
166Recurrent corneal erosions (HP:0000495)1.34096445
167Urticaria (HP:0001025)1.33597825
168Melanocytic nevus (HP:0000995)1.32783616
169Hyperkalemia (HP:0002153)1.32320807
170Skin pits (HP:0100276)1.31484642
171Abnormality of the neuromuscular junction (HP:0003398)1.31238710
172Fatigable weakness (HP:0003473)1.31238710
173Duplicated collecting system (HP:0000081)1.30664149
174Malignant hyperthermia (HP:0002047)1.29108223
175Oligodontia (HP:0000677)1.25840098
176Selective tooth agenesis (HP:0001592)1.25508307
177Villous atrophy (HP:0011473)1.21734031
178Abnormality of small intestinal villus morphology (HP:0011472)1.21734031
179Neonatal short-limb short stature (HP:0008921)1.20095032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.72233402
2LATS13.95532393
3EPHA33.52394060
4LATS23.29117448
5MAP3K63.03850940
6TGFBR22.93235399
7MAP3K92.75415895
8FGFR42.54243509
9MAP3K32.39655950
10NLK2.38277595
11EPHB12.37582293
12STK38L2.35624939
13TGFBR12.22030052
14MST1R2.18623633
15AKT32.10058067
16ERBB41.94929537
17ERN11.91497259
18FER1.89404151
19PDGFRA1.86433149
20ACVR1B1.86332984
21PDK21.80507147
22MAPKAPK31.68439614
23PRKD31.64321897
24FGFR11.58521298
25MYLK1.57929748
26MUSK1.54555386
27BMPR1B1.44766978
28IRAK11.44686999
29PIM21.42416457
30WNK11.41580979
31TTN1.40946334
32DDR21.33689541
33RIPK11.33413060
34TRIB31.32182904
35STK31.23564834
36KDR1.17353045
37JAK31.17284220
38DYRK31.17085477
39BCR1.15711277
40MET1.14501845
41PLK41.05123949
42TAOK31.03011410
43FGFR31.02838574
44MOS1.00906870
45MAP2K31.00874269
46MAP2K10.98643231
47EPHB20.98295713
48PIK3CG0.92187175
49TYK20.91680997
50PDGFRB0.91565620
51DMPK0.91437309
52IKBKE0.90899841
53ADRBK10.89613163
54JAK10.89071395
55IRAK20.88051048
56MAP3K140.87110281
57PRKCH0.84788155
58MARK20.83279668
59TSSK60.82614272
60MTOR0.81576312
61IKBKB0.79183739
62NEK90.78811046
63STK240.78305374
64GSK3A0.75972299
65DYRK20.75927528
66MELK0.74284791
67LRRK20.74276074
68TAOK20.74036270
69STK100.73345971
70CAMK1D0.72814234
71ABL20.72664785
72BMX0.72641413
73EEF2K0.72293051
74PRPF4B0.72253559
75SGK20.72020028
76IRAK40.71600923
77PRKD20.70580255
78JAK20.69948311
79CDK120.68578468
80PKN10.68478604
81SGK4940.67779484
82SGK2230.67779484
83MAPK70.66786201
84FGFR20.65717944
85MAPK40.64527338
86GRK70.63314681
87MAP3K70.61852378
88STK380.61281302
89MAP3K120.60431606
90ILK0.60404240
91NEK60.60227584
92PDK40.58298359
93PDK30.58298359
94TBK10.55329152
95RAF10.55257552
96MAP2K20.54624660
97OBSCN0.52674475
98NTRK10.51062309
99TESK10.49964653
100BRAF0.49578243
101MAPKAPK20.49086086
102SGK10.47590702
103SGK30.47363005
104MAP2K60.47249313
105RPS6KA40.46946114
106TAOK10.46808272
107ABL10.46252348
108EPHA20.45862803
109MAPKAPK50.45861298
110KSR20.45392684
111PRKCE0.45340302
112SIK10.44072597
113PLK20.43756936
114GRK50.42796283
115CSK0.42079859
116MAP3K130.41826495
117IRAK30.41358788
118MAP3K50.41145344
119RPS6KL10.39902224
120RPS6KC10.39902224
121PTK20.38714024
122PAK20.37961132
123ARAF0.37757735
124RPS6KA10.37408007
125TRPM70.37050740
126MAPK150.36447572
127PRKAA10.36107285
128PRKAA20.35526368
129MAP3K10.34918894
130MAPK120.34745274
131CHUK0.34197064
132DYRK1B0.32873641
133MARK30.32306223
134PTK2B0.32297473
135RPS6KA60.31801913
136CDK60.31390363
137BRD40.31075207
138PIM10.30605810
139RPS6KA20.29651764
140MAP3K20.28799828
141LMTK20.27494922
142RET0.27072223
143ROCK10.26886212

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.40702117
2Ether lipid metabolism_Homo sapiens_hsa005653.09868236
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.04271636
4Malaria_Homo sapiens_hsa051442.93341773
5Complement and coagulation cascades_Homo sapiens_hsa046102.56750576
6Caffeine metabolism_Homo sapiens_hsa002322.32717648
7Staphylococcus aureus infection_Homo sapiens_hsa051502.12936300
8Dorso-ventral axis formation_Homo sapiens_hsa043202.06928793
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.04633830
10TGF-beta signaling pathway_Homo sapiens_hsa043501.97266496
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.92113605
12PPAR signaling pathway_Homo sapiens_hsa033201.88772628
13Focal adhesion_Homo sapiens_hsa045101.88562354
14Circadian rhythm_Homo sapiens_hsa047101.78654666
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77000471
16Amoebiasis_Homo sapiens_hsa051461.73930102
17Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.70817862
18Dilated cardiomyopathy_Homo sapiens_hsa054141.57185852
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54336413
20Adherens junction_Homo sapiens_hsa045201.52778390
21Long-term depression_Homo sapiens_hsa047301.49313395
22Protein digestion and absorption_Homo sapiens_hsa049741.40139955
23Toxoplasmosis_Homo sapiens_hsa051451.39229129
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.36749461
25Pentose phosphate pathway_Homo sapiens_hsa000301.35256934
26Pancreatic cancer_Homo sapiens_hsa052121.32164652
27Arachidonic acid metabolism_Homo sapiens_hsa005901.31741326
28Proteoglycans in cancer_Homo sapiens_hsa052051.30873332
29Ovarian steroidogenesis_Homo sapiens_hsa049131.29362466
30Fat digestion and absorption_Homo sapiens_hsa049751.28461617
31Phenylalanine metabolism_Homo sapiens_hsa003601.27747186
32p53 signaling pathway_Homo sapiens_hsa041151.26871911
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.26129760
34Small cell lung cancer_Homo sapiens_hsa052221.24718070
35Vitamin B6 metabolism_Homo sapiens_hsa007501.19683027
36Insulin resistance_Homo sapiens_hsa049311.18730968
37Pertussis_Homo sapiens_hsa051331.15473856
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12748006
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09570115
40Bladder cancer_Homo sapiens_hsa052191.06882525
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06648746
42Arginine biosynthesis_Homo sapiens_hsa002201.05987330
43Prolactin signaling pathway_Homo sapiens_hsa049171.05060399
44FoxO signaling pathway_Homo sapiens_hsa040681.04874581
45Sphingolipid metabolism_Homo sapiens_hsa006001.04278314
46Prion diseases_Homo sapiens_hsa050201.03807915
47Fatty acid elongation_Homo sapiens_hsa000621.01510716
48Thyroid cancer_Homo sapiens_hsa052161.00892542
49MicroRNAs in cancer_Homo sapiens_hsa052060.99613166
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.97813767
51Choline metabolism in cancer_Homo sapiens_hsa052310.97205528
52Hippo signaling pathway_Homo sapiens_hsa043900.95341203
53Vitamin digestion and absorption_Homo sapiens_hsa049770.94367208
54Pathways in cancer_Homo sapiens_hsa052000.91611149
55Fatty acid biosynthesis_Homo sapiens_hsa000610.89889146
56TNF signaling pathway_Homo sapiens_hsa046680.89177335
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89047283
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.86819812
59Melanoma_Homo sapiens_hsa052180.86488459
60Renin secretion_Homo sapiens_hsa049240.85402628
61Serotonergic synapse_Homo sapiens_hsa047260.85177991
62African trypanosomiasis_Homo sapiens_hsa051430.84765261
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83856444
64Notch signaling pathway_Homo sapiens_hsa043300.82973052
65Ras signaling pathway_Homo sapiens_hsa040140.82575175
66Viral myocarditis_Homo sapiens_hsa054160.82391610
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81834734
68Pancreatic secretion_Homo sapiens_hsa049720.80271675
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80260965
70Inositol phosphate metabolism_Homo sapiens_hsa005620.79648768
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.76449075
72Hepatitis C_Homo sapiens_hsa051600.75312641
73ErbB signaling pathway_Homo sapiens_hsa040120.74746986
74Fatty acid degradation_Homo sapiens_hsa000710.74583993
75Histidine metabolism_Homo sapiens_hsa003400.72818938
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.72009369
77Chronic myeloid leukemia_Homo sapiens_hsa052200.71975602
78Rap1 signaling pathway_Homo sapiens_hsa040150.71558759
79Mineral absorption_Homo sapiens_hsa049780.70306286
80Prostate cancer_Homo sapiens_hsa052150.69860193
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.69300190
82Cell cycle_Homo sapiens_hsa041100.69115074
83Osteoclast differentiation_Homo sapiens_hsa043800.67563795
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67213001
85Influenza A_Homo sapiens_hsa051640.66490318
86GnRH signaling pathway_Homo sapiens_hsa049120.66390702
87Apoptosis_Homo sapiens_hsa042100.66390513
88Linoleic acid metabolism_Homo sapiens_hsa005910.65414084
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65140271
90Oxytocin signaling pathway_Homo sapiens_hsa049210.63811899
91Leishmaniasis_Homo sapiens_hsa051400.62563024
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62185133
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61960630
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60283723
95Insulin signaling pathway_Homo sapiens_hsa049100.59980305
96MAPK signaling pathway_Homo sapiens_hsa040100.59677745
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59463634
98Starch and sucrose metabolism_Homo sapiens_hsa005000.58490890
99Phagosome_Homo sapiens_hsa041450.58393272
100Tight junction_Homo sapiens_hsa045300.57823365
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.57275598
102Renal cell carcinoma_Homo sapiens_hsa052110.55421391
103HIF-1 signaling pathway_Homo sapiens_hsa040660.53870519
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53594531
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53287434
106Rheumatoid arthritis_Homo sapiens_hsa053230.52790558
107HTLV-I infection_Homo sapiens_hsa051660.52074001
108Glutamatergic synapse_Homo sapiens_hsa047240.51804751
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51403878
110Melanogenesis_Homo sapiens_hsa049160.50736998
111Calcium signaling pathway_Homo sapiens_hsa040200.49731958
112Estrogen signaling pathway_Homo sapiens_hsa049150.49421364
113Retinol metabolism_Homo sapiens_hsa008300.49314772
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48612257
115Glioma_Homo sapiens_hsa052140.48243318
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47304424
117Salmonella infection_Homo sapiens_hsa051320.47169934
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.47036813
119Fatty acid metabolism_Homo sapiens_hsa012120.45821690
120VEGF signaling pathway_Homo sapiens_hsa043700.44740807
121Endocytosis_Homo sapiens_hsa041440.42997251
122Hepatitis B_Homo sapiens_hsa051610.42916291
123Glutathione metabolism_Homo sapiens_hsa004800.42358215
124Acute myeloid leukemia_Homo sapiens_hsa052210.41946172
125mTOR signaling pathway_Homo sapiens_hsa041500.41460754
126Other glycan degradation_Homo sapiens_hsa005110.41331132
127Platelet activation_Homo sapiens_hsa046110.40188695
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40031706
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39883993
130AMPK signaling pathway_Homo sapiens_hsa041520.39095504
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38750397
132Salivary secretion_Homo sapiens_hsa049700.38571653
133ABC transporters_Homo sapiens_hsa020100.37549509
134Gastric acid secretion_Homo sapiens_hsa049710.36950599
135Hedgehog signaling pathway_Homo sapiens_hsa043400.36616192
136Tyrosine metabolism_Homo sapiens_hsa003500.36589825
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36094532
138Axon guidance_Homo sapiens_hsa043600.35313081
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34189937

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