SLC10A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.14809892
2epoxygenase P450 pathway (GO:0019373)7.74647636
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.62122395
4L-phenylalanine catabolic process (GO:0006559)7.62122395
5L-phenylalanine metabolic process (GO:0006558)7.27848256
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.27848256
7omega-hydroxylase P450 pathway (GO:0097267)7.06818413
8aromatic amino acid family catabolic process (GO:0009074)6.86201497
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.43615048
10oxidative demethylation (GO:0070989)6.31564371
11phenylpropanoid metabolic process (GO:0009698)6.26946186
12tryptophan catabolic process (GO:0006569)6.18612866
13indole-containing compound catabolic process (GO:0042436)6.18612866
14indolalkylamine catabolic process (GO:0046218)6.18612866
15drug metabolic process (GO:0017144)6.16714481
16kynurenine metabolic process (GO:0070189)6.06966019
17bile acid biosynthetic process (GO:0006699)6.00977129
18tryptophan metabolic process (GO:0006568)5.81977898
19glyoxylate metabolic process (GO:0046487)5.78569740
20alpha-linolenic acid metabolic process (GO:0036109)5.69407086
21urea metabolic process (GO:0019627)5.67730157
22urea cycle (GO:0000050)5.67730157
23negative regulation of fibrinolysis (GO:0051918)5.66157166
24high-density lipoprotein particle remodeling (GO:0034375)5.64880781
25regulation of fibrinolysis (GO:0051917)5.46079707
26peptidyl-glutamic acid carboxylation (GO:0017187)5.43145221
27protein carboxylation (GO:0018214)5.43145221
28sulfur amino acid catabolic process (GO:0000098)5.34170107
29cysteine metabolic process (GO:0006534)5.32203793
30complement activation, alternative pathway (GO:0006957)5.30167554
31regulation of protein activation cascade (GO:2000257)5.28445825
32nitrogen cycle metabolic process (GO:0071941)5.21903406
33serine family amino acid catabolic process (GO:0009071)5.14371744
34alkaloid metabolic process (GO:0009820)5.04823145
35* bile acid metabolic process (GO:0008206)4.98624973
36aromatic amino acid family metabolic process (GO:0009072)4.98249756
37regulation of cholesterol esterification (GO:0010872)4.92901445
38regulation of complement activation (GO:0030449)4.92885872
39reverse cholesterol transport (GO:0043691)4.92576833
40regulation of plasminogen activation (GO:0010755)4.89425968
41regulation of triglyceride catabolic process (GO:0010896)4.86018128
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85290310
43tyrosine metabolic process (GO:0006570)4.83950977
44protein-lipid complex remodeling (GO:0034368)4.81514930
45macromolecular complex remodeling (GO:0034367)4.81514930
46plasma lipoprotein particle remodeling (GO:0034369)4.81514930
47negative regulation of hemostasis (GO:1900047)4.78387869
48negative regulation of blood coagulation (GO:0030195)4.78387869
49homocysteine metabolic process (GO:0050667)4.73462203
50alpha-amino acid catabolic process (GO:1901606)4.66087135
51acylglycerol homeostasis (GO:0055090)4.65222643
52triglyceride homeostasis (GO:0070328)4.65222643
53negative regulation of sterol transport (GO:0032372)4.63121404
54negative regulation of cholesterol transport (GO:0032375)4.63121404
55amino-acid betaine metabolic process (GO:0006577)4.62786102
56phospholipid efflux (GO:0033700)4.61553748
57hormone catabolic process (GO:0042447)4.61082003
58lysine catabolic process (GO:0006554)4.58121341
59lysine metabolic process (GO:0006553)4.58121341
60ethanol metabolic process (GO:0006067)4.57097398
61cellular ketone body metabolic process (GO:0046950)4.52749744
62S-adenosylmethionine metabolic process (GO:0046500)4.48347932
63negative regulation of protein activation cascade (GO:2000258)4.46271587
64glycine metabolic process (GO:0006544)4.44107828
65plasma lipoprotein particle clearance (GO:0034381)4.42164092
66coenzyme catabolic process (GO:0009109)4.39107939
67imidazole-containing compound metabolic process (GO:0052803)4.38290201
68indolalkylamine metabolic process (GO:0006586)4.38053969
69negative regulation of wound healing (GO:0061045)4.36398569
70negative regulation of coagulation (GO:0050819)4.35707521
71steroid catabolic process (GO:0006706)4.34344866
72amine catabolic process (GO:0009310)4.29798440
73cellular biogenic amine catabolic process (GO:0042402)4.29798440
74cellular glucuronidation (GO:0052695)4.29193252
75cellular amino acid catabolic process (GO:0009063)4.28336876
76cholesterol efflux (GO:0033344)4.26241442
77glutamate metabolic process (GO:0006536)4.24117349
78heme transport (GO:0015886)4.21120389
79serine family amino acid metabolic process (GO:0009069)4.17568957
80benzene-containing compound metabolic process (GO:0042537)4.14685570
81ethanol oxidation (GO:0006069)4.13677728
82* bile acid and bile salt transport (GO:0015721)4.12735497
83regulation of humoral immune response (GO:0002920)4.05453488
84low-density lipoprotein particle remodeling (GO:0034374)4.04365149
85arginine metabolic process (GO:0006525)4.04333612
86cellular modified amino acid catabolic process (GO:0042219)4.04265737
87dicarboxylic acid biosynthetic process (GO:0043650)4.03439786
88fibrinolysis (GO:0042730)4.03256270
89plasma lipoprotein particle assembly (GO:0034377)4.01346117
90aldehyde catabolic process (GO:0046185)4.00874475
91serine family amino acid biosynthetic process (GO:0009070)4.00818882
92flavonoid metabolic process (GO:0009812)3.98136540
93positive regulation of blood coagulation (GO:0030194)3.97974127
94positive regulation of hemostasis (GO:1900048)3.97974127
95negative regulation of complement activation (GO:0045916)3.96949482
96acute-phase response (GO:0006953)3.96717958
97drug catabolic process (GO:0042737)3.95984135
98ketone body metabolic process (GO:1902224)3.92093167
99blood coagulation, intrinsic pathway (GO:0007597)3.89491088
100regulation of lipoprotein particle clearance (GO:0010984)3.88837558
101positive regulation of lipoprotein lipase activity (GO:0051006)3.82217669
102positive regulation of triglyceride lipase activity (GO:0061365)3.82217669
103glucuronate metabolic process (GO:0019585)3.80937896
104uronic acid metabolic process (GO:0006063)3.80937896
105cofactor catabolic process (GO:0051187)3.80700941
106negative regulation of lipase activity (GO:0060192)3.78570103
107positive regulation of lipid catabolic process (GO:0050996)3.78360575
108phospholipid homeostasis (GO:0055091)3.76949408
109cholesterol homeostasis (GO:0042632)3.76698741
110complement activation, classical pathway (GO:0006958)3.75365954
111regulation of bile acid biosynthetic process (GO:0070857)3.75252588
112organic acid catabolic process (GO:0016054)3.75184031
113carboxylic acid catabolic process (GO:0046395)3.75184031
114very-low-density lipoprotein particle assembly (GO:0034379)3.73225230
115complement activation (GO:0006956)3.72475941
116protein activation cascade (GO:0072376)3.72425273
117sterol homeostasis (GO:0055092)3.70454664
118short-chain fatty acid metabolic process (GO:0046459)3.70084513
119positive regulation of coagulation (GO:0050820)3.69825663
120acetyl-CoA metabolic process (GO:0006084)3.68788372
121drug transmembrane transport (GO:0006855)3.68265317
122xenobiotic metabolic process (GO:0006805)3.68179062
123plasma lipoprotein particle organization (GO:0071827)3.65467449
124cytolysis (GO:0019835)3.63804535
125regulation of cholesterol homeostasis (GO:2000188)3.61580499
126protein-lipid complex assembly (GO:0065005)3.59786537
127NAD biosynthetic process (GO:0009435)3.57900753
128nicotinamide nucleotide biosynthetic process (GO:0019359)3.54807252
129negative regulation of fatty acid biosynthetic process (GO:0045717)3.47551261
130polyketide metabolic process (GO:0030638)3.44276322
131doxorubicin metabolic process (GO:0044598)3.44276322
132daunorubicin metabolic process (GO:0044597)3.44276322
133intestinal cholesterol absorption (GO:0030299)3.44084224

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.42933963
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22557821
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.03044638
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.51813251
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.31727271
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.05011248
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.83502227
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05150440
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.89383322
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07828978
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0115066
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97211441
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95277059
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.59437480
15HTT_18923047_ChIP-ChIP_STHdh_Human1.58846589
16CLOCK_20551151_ChIP-Seq_293T_Human1.53105184
17GATA1_22025678_ChIP-Seq_K562_Human1.43422647
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39834508
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27100645
20RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20074776
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17853942
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17518336
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.15356541
24CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14064156
25HNFA_21074721_ChIP-Seq_CACO-2_Human1.08405655
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.05347204
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04966749
28PHF8_20622853_ChIP-Seq_HELA_Human1.03318444
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02962987
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02275114
31GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02140415
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99144325
33ER_23166858_ChIP-Seq_MCF-7_Human0.98147190
34SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96224591
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95856976
36GATA6_21074721_ChIP-Seq_CACO-2_Human0.94539474
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91856952
38SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90903124
39PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89897385
40NFYA_21822215_ChIP-Seq_K562_Human0.89192015
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87198606
42AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84976084
43CRX_20693478_ChIP-Seq_RETINA_Mouse0.84879271
44IRF1_19129219_ChIP-ChIP_H3396_Human0.84195410
45IRF8_22096565_ChIP-ChIP_GC-B_Human0.83803099
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83235247
47PIAS1_25552417_ChIP-Seq_VCAP_Human0.82016727
48CBX2_22325352_ChIP-Seq_293T-Rex_Human0.81443645
49RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80377789
50GATA4_25053715_ChIP-Seq_YYC3_Human0.80162515
51OCT4_21477851_ChIP-Seq_ESCs_Mouse0.79195465
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78778289
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78143137
54TP53_18474530_ChIP-ChIP_U2OS_Human0.77960640
55KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77458996
56SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77011022
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76668821
58ETV1_20927104_ChIP-Seq_GIST48_Human0.75379864
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.74672667
60SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74328847
61ETV2_25802403_ChIP-Seq_MESCs_Mouse0.74300262
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74032874
63RARA_24833708_ChIP-Seq_LIVER_Mouse0.73614917
64POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72037187
65RBPJ_21746931_ChIP-Seq_IB4_Human0.71190853
66ZNF263_19887448_ChIP-Seq_K562_Human0.70958767
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70658983
68SOX2_21211035_ChIP-Seq_LN229_Human0.70332571
69SOX2_20726797_ChIP-Seq_SW620_Human0.69960457
70TCF4_18268006_ChIP-ChIP_LS174T_Human0.69704843
71PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.69576741
72RUNX1_27457419_Chip-Seq_LIVER_Mouse0.68658970
73SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67021056
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66795338
75OCT4_18555785_Chip-Seq_ESCs_Mouse0.66740671
76TRIM28_21343339_ChIP-Seq_HEK293_Human0.66638451
77SMAD1_18555785_Chip-Seq_ESCs_Mouse0.65740301
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65562433
79GBX2_23144817_ChIP-Seq_PC3_Human0.65496919
80NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65349468
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65349468
82NFYB_21822215_ChIP-Seq_K562_Human0.65231734
83ESRRB_18555785_Chip-Seq_ESCs_Mouse0.64417829
84ESR2_21235772_ChIP-Seq_MCF-7_Human0.64394053
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.64115740
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.64111464
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.64074575
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.63552887
89CBP_20019798_ChIP-Seq_JUKART_Human0.63441070
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.63441070
91RARB_24833708_ChIP-Seq_LIVER_Mouse0.63425217
92* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.63253400
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.63207697
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62799544
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.62746033
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62394907
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61046529
98TP53_16413492_ChIP-PET_HCT116_Human0.59810449
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.58842028
100FOXA1_25329375_ChIP-Seq_VCAP_Human0.58842028
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58801213
102NANOG_19829295_ChIP-Seq_ESCs_Human0.57842171
103* CEBPB_22108803_ChIP-Seq_LS180_Human0.54455698
104* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53201304
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.53187886
106EGR1_19032775_ChIP-ChIP_M12_Human0.53092706
107FOXA1_25552417_ChIP-Seq_VCAP_Human0.52897211
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52131957
109LXR_22292898_ChIP-Seq_THP-1_Human0.51909134
110MYC_19915707_ChIP-ChIP_AK7_Human0.51309594
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51004600
112FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50365678
113ESET_19884257_ChIP-Seq_ESCs_Mouse0.49775016
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49435797
115TAF15_26573619_Chip-Seq_HEK293_Human0.49350553
116* AR_20517297_ChIP-Seq_VCAP_Human0.48803912
117CBP_21632823_ChIP-Seq_H3396_Human0.48483393
118STAT1_17558387_ChIP-Seq_HELA_Human0.48476609
119P53_21459846_ChIP-Seq_SAOS-2_Human0.46498890
120PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46239764
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.44753241
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44319954
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43122525
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.42630349
125CDX2_20551321_ChIP-Seq_CACO-2_Human0.42267588
126GATA1_19941826_ChIP-Seq_K562_Human0.42078878
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.41498276
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41413604
129TAF2_19829295_ChIP-Seq_ESCs_Human0.41081260
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.41031198
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40287236
132SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40192824
133BCAT_22108803_ChIP-Seq_LS180_Human0.39986334
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.39749279
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.39594537
136GATA2_19941826_ChIP-Seq_K562_Human0.39123306
137PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39021462
138GATA6_25053715_ChIP-Seq_YYC3_Human0.37502408
139MYC_27129775_Chip-Seq_CORNEA_Mouse0.37321353
140STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37003726
141SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36670619
142LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36493220
143GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.34722708
144SPI1_26923725_Chip-Seq_HPCs_Mouse0.34648138
145NCOR_22424771_ChIP-Seq_293T_Human0.33887658
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33485422
147FOXH1_21741376_ChIP-Seq_EPCs_Human0.33165181
148CDX2_22108803_ChIP-Seq_LS180_Human0.33114664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.35681907
2MP0005360_urolithiasis7.55664543
3MP0005085_abnormal_gallbladder_physiolo6.47642279
4MP0005365_abnormal_bile_salt6.18729072
5MP0008875_abnormal_xenobiotic_pharmacok5.19231281
6MP0003806_abnormal_nucleotide_metabolis4.26299956
7MP0003252_abnormal_bile_duct3.92536427
8MP0010329_abnormal_lipoprotein_level3.60056439
9MP0009840_abnormal_foam_cell3.32332309
10MP0005083_abnormal_biliary_tract3.11388836
11MP0003195_calcinosis2.83130904
12MP0005332_abnormal_amino_acid2.74814755
13MP0001666_abnormal_nutrient_absorption2.58936151
14MP0003191_abnormal_cellular_cholesterol2.28607033
15MP0000609_abnormal_liver_physiology2.16456014
16MP0004019_abnormal_vitamin_homeostasis2.11987283
17MP0002118_abnormal_lipid_homeostasis2.10842416
18MP0002138_abnormal_hepatobiliary_system1.95311764
19MP0003868_abnormal_feces_composition1.94257330
20MP0005319_abnormal_enzyme/_coenzyme1.82544978
21MP0001764_abnormal_homeostasis1.67550310
22MP0009697_abnormal_copulation1.61696911
23MP0005584_abnormal_enzyme/coenzyme_acti1.56929398
24MP0005451_abnormal_body_composition1.48377287
25MP0003011_delayed_dark_adaptation1.38051428
26MP0003656_abnormal_erythrocyte_physiolo1.27246967
27MP0003186_abnormal_redox_activity1.26031993
28MP0009643_abnormal_urine_homeostasis1.20759120
29MP0000598_abnormal_liver_morphology1.17579653
30MP0005647_abnormal_sex_gland1.14160666
31MP0003705_abnormal_hypodermis_morpholog1.13071256
32MP0005187_abnormal_penis_morphology1.12113447
33MP0000604_amyloidosis1.09220838
34MP0009764_decreased_sensitivity_to1.05367713
35MP0009763_increased_sensitivity_to1.02010123
36MP0002254_reproductive_system_inflammat1.00646768
37MP0010368_abnormal_lymphatic_system0.96910220
38MP0005636_abnormal_mineral_homeostasis0.88996346
39MP0001915_intracranial_hemorrhage0.88795502
40MP0008469_abnormal_protein_level0.88147898
41MP0009642_abnormal_blood_homeostasis0.86493345
42MP0005408_hypopigmentation0.85420401
43MP0006036_abnormal_mitochondrial_physio0.81671012
44MP0005376_homeostasis/metabolism_phenot0.79810441
45MP0009765_abnormal_xenobiotic_induced0.78490327
46MP0002078_abnormal_glucose_homeostasis0.77252401
47MP0005670_abnormal_white_adipose0.77076309
48MP0002876_abnormal_thyroid_physiology0.76339308
49MP0005084_abnormal_gallbladder_morpholo0.76003392
50MP0002971_abnormal_brown_adipose0.70773366
51MP0005220_abnormal_exocrine_pancreas0.70034509
52MP0003690_abnormal_glial_cell0.69048630
53MP0005334_abnormal_fat_pad0.69031295
54MP0004130_abnormal_muscle_cell0.68784184
55MP0005535_abnormal_body_temperature0.66939354
56MP0001661_extended_life_span0.65922119
57MP0009053_abnormal_anal_canal0.65559213
58MP0005266_abnormal_metabolism0.64692769
59MP0003329_amyloid_beta_deposits0.63537317
60MP0000639_abnormal_adrenal_gland0.61216161
61MP0010386_abnormal_urinary_bladder0.60100670
62MP0001756_abnormal_urination0.57686781
63MP0006035_abnormal_mitochondrial_morpho0.55981888
64MP0005448_abnormal_energy_balance0.55369797
65MP0003879_abnormal_hair_cell0.54507174
66MP0005464_abnormal_platelet_physiology0.53003888
67MP0002822_catalepsy0.52643801
68MP0005058_abnormal_lysosome_morphology0.51792935
69MP0005395_other_phenotype0.48492727
70MP0008874_decreased_physiological_sensi0.46584708
71MP0003638_abnormal_response/metabolism_0.45933040
72MP0003718_maternal_effect0.45899816
73MP0002928_abnormal_bile_duct0.44721224
74MP0008873_increased_physiological_sensi0.44424741
75MP0002136_abnormal_kidney_physiology0.43454333
76MP0004782_abnormal_surfactant_physiolog0.43366805
77MP0002282_abnormal_trachea_morphology0.42063148
78MP0003436_decreased_susceptibility_to0.42016471
79MP0002837_dystrophic_cardiac_calcinosis0.41810121
80MP0003724_increased_susceptibility_to0.41597498
81MP0003075_altered_response_to0.40910711
82MP0005248_abnormal_Harderian_gland0.40332190
83MP0003953_abnormal_hormone_level0.40085038
84MP0004381_abnormal_hair_follicle0.38973956
85MP0008872_abnormal_physiological_respon0.38873398
86MP0009672_abnormal_birth_weight0.37703454
87MP0005166_decreased_susceptibility_to0.37232829
88MP0005666_abnormal_adipose_tissue0.35344526
89MP0001986_abnormal_taste_sensitivity0.35234374
90MP0004883_abnormal_blood_vessel0.32997889
91MP0006082_CNS_inflammation0.32758904
92MP0000579_abnormal_nail_morphology0.32702725
93MP0000249_abnormal_blood_vessel0.32648798
94MP0001243_abnormal_dermal_layer0.32444086
95MP0009115_abnormal_fat_cell0.32249305
96MP0002796_impaired_skin_barrier0.31930011
97MP0002168_other_aberrant_phenotype0.30917845
98MP0001853_heart_inflammation0.30782155
99MP0009785_altered_susceptibility_to0.30750088
100MP0000230_abnormal_systemic_arterial0.30694994
101MP0003959_abnormal_lean_body0.30155437
102MP0002970_abnormal_white_adipose0.29560117
103MP0002089_abnormal_postnatal_growth/wei0.29310149
104MP0005023_abnormal_wound_healing0.29271063
105MP0001845_abnormal_inflammatory_respons0.27524775
106MP0001881_abnormal_mammary_gland0.26957466
107MP0009384_cardiac_valve_regurgitation0.26930764
108MP0005197_abnormal_uvea_morphology0.25442782
109MP0002090_abnormal_vision0.25346334
110MP0002132_abnormal_respiratory_system0.24943839
111MP0005164_abnormal_response_to0.24818256
112MP0002332_abnormal_exercise_endurance0.23091124
113MP0002060_abnormal_skin_morphology0.23071899
114MP0004142_abnormal_muscle_tone0.22433566
115MP0005167_abnormal_blood-brain_barrier0.18557846
116MP0001324_abnormal_eye_pigmentation0.17914524
117MP0003632_abnormal_nervous_system0.17587339
118MP0002249_abnormal_larynx_morphology0.15316191
119MP0005551_abnormal_eye_electrophysiolog0.14918465
120MP0003631_nervous_system_phenotype0.14304702
121MP0005646_abnormal_pituitary_gland0.14049042
122MP0000371_diluted_coat_color0.14027613

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.50757363
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.46008607
3Intrahepatic cholestasis (HP:0001406)7.34906406
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.69891953
5Prolonged partial thromboplastin time (HP:0003645)6.64908887
6Hypobetalipoproteinemia (HP:0003563)6.46521535
7Xanthomatosis (HP:0000991)6.28876867
8Hyperlipoproteinemia (HP:0010980)5.64819616
9Complement deficiency (HP:0004431)5.30383219
10Joint hemorrhage (HP:0005261)4.86069824
11Hypolipoproteinemia (HP:0010981)4.83801890
12Hyperammonemia (HP:0001987)4.61918714
13Epidermoid cyst (HP:0200040)4.47733673
14Abnormality of the common coagulation pathway (HP:0010990)4.45740359
15Hyperglycinemia (HP:0002154)4.44522598
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.42361796
17Abnormality of methionine metabolism (HP:0010901)4.32347413
18Ketosis (HP:0001946)4.27185050
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.25278857
20Hypoalphalipoproteinemia (HP:0003233)4.24394251
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13767810
22Fat malabsorption (HP:0002630)4.12189683
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09284778
24Abnormality of serine family amino acid metabolism (HP:0010894)3.90620033
25Abnormality of glycine metabolism (HP:0010895)3.90620033
26Hyperglycinuria (HP:0003108)3.90103102
27Abnormality of pyrimidine metabolism (HP:0004353)3.87658303
28Abnormality of complement system (HP:0005339)3.86748312
29Hypoglycemic coma (HP:0001325)3.84513516
30Abnormality of the intrinsic pathway (HP:0010989)3.79376178
31Conjugated hyperbilirubinemia (HP:0002908)3.74549821
32Reduced antithrombin III activity (HP:0001976)3.74540038
33Hypercholesterolemia (HP:0003124)3.64555315
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38892539
35Hyperbilirubinemia (HP:0002904)3.37824550
36Abnormality of fatty-acid metabolism (HP:0004359)3.35042879
37Osteomalacia (HP:0002749)3.18846988
38Delayed CNS myelination (HP:0002188)3.14219730
39Steatorrhea (HP:0002570)3.12612567
40Abnormality of serum amino acid levels (HP:0003112)3.08350435
41Abnormality of nucleobase metabolism (HP:0010932)3.06557146
42Hepatocellular carcinoma (HP:0001402)3.00213766
43Hypochromic microcytic anemia (HP:0004840)3.00133306
44Ketoacidosis (HP:0001993)2.99177418
45Spontaneous abortion (HP:0005268)2.97880583
46Myocardial infarction (HP:0001658)2.94791799
47Metabolic acidosis (HP:0001942)2.76591395
48Skin nodule (HP:0200036)2.75732165
49Systemic lupus erythematosus (HP:0002725)2.70551827
50Abnormality of purine metabolism (HP:0004352)2.66006567
51Pulmonary embolism (HP:0002204)2.64687887
52Lethargy (HP:0001254)2.60103851
53Vascular calcification (HP:0004934)2.59498046
54Dicarboxylic aciduria (HP:0003215)2.59028936
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59028936
56Fair hair (HP:0002286)2.56098233
57Acanthocytosis (HP:0001927)2.53519491
58Abnormal gallbladder morphology (HP:0012437)2.49622483
59Spastic diplegia (HP:0001264)2.46087815
60Glomerulonephritis (HP:0000099)2.45047218
61Arthropathy (HP:0003040)2.44885332
62Hypoglycemic seizures (HP:0002173)2.44440619
63Cholelithiasis (HP:0001081)2.42811588
64Mitral stenosis (HP:0001718)2.42623012
65Cerebral edema (HP:0002181)2.41353207
66Gout (HP:0001997)2.40235300
67Cholecystitis (HP:0001082)2.37651065
68Abnormal gallbladder physiology (HP:0012438)2.37651065
69Neonatal hypoglycemia (HP:0001998)2.36531488
70Irritability (HP:0000737)2.35087408
71Neonatal onset (HP:0003623)2.34146226
72Hyperphosphaturia (HP:0003109)2.34102552
73Recurrent gram-negative bacterial infections (HP:0005420)2.33777118
74Cardiovascular calcification (HP:0011915)2.30232545
75Amyloidosis (HP:0011034)2.29950717
76Glycosuria (HP:0003076)2.29631746
77Abnormality of urine glucose concentration (HP:0011016)2.29631746
78Malnutrition (HP:0004395)2.25153609
79Purpura (HP:0000979)2.21731626
80Gingival bleeding (HP:0000225)2.20977686
81Bile duct proliferation (HP:0001408)2.19598247
82Abnormal biliary tract physiology (HP:0012439)2.19598247
83Esophageal varix (HP:0002040)2.19014687
84Menorrhagia (HP:0000132)2.18513718
85Pancreatitis (HP:0001733)2.13921776
86Brushfield spots (HP:0001088)2.13582003
87Sensorimotor neuropathy (HP:0007141)2.12993989
88Elevated alkaline phosphatase (HP:0003155)2.11057652
89Enlarged kidneys (HP:0000105)2.09687190
90Late onset (HP:0003584)2.09232385
91Thrombophlebitis (HP:0004418)2.07704593
92Vomiting (HP:0002013)2.05939091
93Abnormality of the Achilles tendon (HP:0005109)2.04342864
94Opisthotonus (HP:0002179)2.03231076
95Generalized aminoaciduria (HP:0002909)2.03225309
96Abnormality of the gallbladder (HP:0005264)2.02300213
97Poikilocytosis (HP:0004447)2.02229166
98Hemorrhage of the eye (HP:0011885)2.01085666
99Hyperinsulinemic hypoglycemia (HP:0000825)1.97828385
100Rickets (HP:0002748)1.93027680
101Abnormality of alkaline phosphatase activity (HP:0004379)1.92117069
102Increased serum ferritin (HP:0003281)1.90573286
103Renal cortical cysts (HP:0000803)1.87893644
104Abnormality of iron homeostasis (HP:0011031)1.87308402
105Hypophosphatemic rickets (HP:0004912)1.87285249
106Gangrene (HP:0100758)1.86333462
107Abnormal urine phosphate concentration (HP:0012599)1.85960810
108Abnormal cartilage morphology (HP:0002763)1.85930664
109Abnormality of transition element cation homeostasis (HP:0011030)1.84236268
110Atrioventricular block (HP:0001678)1.83269130
111Abnormality of proline metabolism (HP:0010907)1.81532786
112Hydroxyprolinuria (HP:0003080)1.81532786
113Elevated hepatic transaminases (HP:0002910)1.81119332
114Status epilepticus (HP:0002133)1.81097317
115Retinal atrophy (HP:0001105)1.80579950
116Abnormal enzyme/coenzyme activity (HP:0012379)1.80398211
117Alkalosis (HP:0001948)1.78865683
118Generalized hypopigmentation of hair (HP:0011358)1.77820376
119Abnormality of vitamin metabolism (HP:0100508)1.74328958
120Nephritis (HP:0000123)1.73782317
121Hyperglycemia (HP:0003074)1.72657881
122Proximal tubulopathy (HP:0000114)1.71209413
123Epistaxis (HP:0000421)1.61185239
124Abnormal pupillary function (HP:0007686)1.56366688
125Joint swelling (HP:0001386)1.52973767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.24832682
2SIK14.64118288
3FGFR44.61214114
4ERN14.31984634
5MUSK3.36638511
6TAOK33.12692174
7INSRR2.96406762
8ERBB42.80986014
9MAP2K42.36896607
10PKN22.35313785
11PDK22.28461627
12ACVR1B2.22156355
13MAP3K122.10707273
14MST1R2.07520987
15FLT32.01184515
16PIK3CG1.86156284
17MAPK111.83217164
18BLK1.77566565
19CDK121.74716317
20TRIB31.73087776
21TYK21.71894156
22LATS11.63328878
23DAPK21.51352766
24ABL21.50500849
25PTK61.43835267
26FGFR21.41406979
27NEK91.36940026
28AKT31.35365625
29KDR1.34125297
30FRK1.32335069
31NTRK31.31062162
32MYLK1.26638365
33JAK21.22049217
34TESK21.20268714
35MAP3K71.19294935
36BRD41.16703043
37PINK11.16283032
38PRKAA21.12771117
39WNK31.09805106
40MAP2K31.08055613
41GRK61.07951262
42TBK11.05287535
43MAP3K141.01912224
44JAK11.01366779
45ERBB20.99722195
46MAPK40.99125196
47MAP3K100.97442980
48EIF2AK30.97428883
49CAMKK20.97415642
50MAP3K20.97089955
51PRKG10.93170356
52PRKCZ0.92869022
53NLK0.92544864
54CSNK1D0.87962807
55MET0.86719942
56EPHB10.86698446
57STK38L0.84705120
58PRKACA0.83140518
59TNK20.83105276
60CDK60.81780609
61MAPK120.81419688
62MAPK150.81195889
63MAP3K30.80929471
64TIE10.80541285
65MAP3K110.78232101
66SGK10.77849161
67PRKACG0.76357103
68EPHA30.75384844
69CSK0.74414864
70CAMK1D0.72683887
71FER0.71220302
72ARAF0.69312258
73DYRK1B0.68913605
74CAMK2G0.68756168
75MAP2K60.68126116
76STK380.67943924
77GSK3A0.66814541
78PRKAA10.64949137
79PRKCB0.64616948
80IRAK30.64456463
81CASK0.64396055
82MAP3K90.63726993
83PRKCE0.63026432
84SGK30.62336681
85CSF1R0.62242483
86TGFBR20.59741054
87MAPK70.59735619
88STK160.59157553
89PRKACB0.57819224
90FGFR30.56616505
91IKBKE0.55067695
92RIPK10.54991870
93PTK20.54254669
94PRKCQ0.53384520
95PDPK10.50943371
96EPHA40.50772816
97CSNK1G10.49721802
98RPS6KA30.49511514
99TAOK20.46511918
100GRK10.45696662
101SGK20.45147699
102IGF1R0.44832737
103MAP3K130.44250979
104RET0.44197275
105PRPF4B0.43330233
106PBK0.42746767
107MAP3K50.42349128
108BMPR1B0.42052740
109DYRK1A0.41982385
110CDK40.41512625
111PRKCG0.40684995
112CSNK1A10.40595782
113MAP2K10.39171431
114PKN10.38351713
115ICK0.37763768
116MAP3K60.37191523
117CDK90.35955862
118MTOR0.34938602
119KSR20.34281640
120MAP4K20.34130769
121EGFR0.33744769
122IKBKB0.33586943
123PDK10.32536270
124CAMK40.32275023
125CAMKK10.30998367
126SGK4940.30915323
127SGK2230.30915323
128CSNK1G20.29533331
129RAF10.29149454
130CHUK0.28666966
131MAP3K10.27449297
132IRAK20.27375594
133CSNK1G30.26597447
134LATS20.26591121
135CAMK1G0.26521629
136PRKCA0.25833499
137IRAK10.25464072
138PIK3CA0.24223211
139ABL10.21717814
140PAK30.21273219
141PDK40.20578342
142PDK30.20578342

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.54760275
2Nitrogen metabolism_Homo sapiens_hsa009103.55335142
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39542498
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37302491
5Arginine biosynthesis_Homo sapiens_hsa002203.05493889
6Complement and coagulation cascades_Homo sapiens_hsa046102.75836100
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.74164978
8Tryptophan metabolism_Homo sapiens_hsa003802.69016027
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63544330
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53071718
11Fatty acid degradation_Homo sapiens_hsa000712.48643912
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38364116
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27763697
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16599944
15Butanoate metabolism_Homo sapiens_hsa006502.16151897
16Peroxisome_Homo sapiens_hsa041462.07466748
17Chemical carcinogenesis_Homo sapiens_hsa052041.97424134
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.96967065
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95583873
20Propanoate metabolism_Homo sapiens_hsa006401.93298682
21Histidine metabolism_Homo sapiens_hsa003401.91286098
22PPAR signaling pathway_Homo sapiens_hsa033201.86736581
23Fatty acid metabolism_Homo sapiens_hsa012121.81914468
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.79609487
25Staphylococcus aureus infection_Homo sapiens_hsa051501.76340887
26Caffeine metabolism_Homo sapiens_hsa002321.76217206
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73405501
28Retinol metabolism_Homo sapiens_hsa008301.73104755
29beta-Alanine metabolism_Homo sapiens_hsa004101.71595755
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67202183
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63540317
32Selenocompound metabolism_Homo sapiens_hsa004501.56789570
33Phenylalanine metabolism_Homo sapiens_hsa003601.56080413
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50307325
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48736130
36Tyrosine metabolism_Homo sapiens_hsa003501.44242853
37* Bile secretion_Homo sapiens_hsa049761.40237051
38Pyruvate metabolism_Homo sapiens_hsa006201.37153525
39Fatty acid elongation_Homo sapiens_hsa000621.35454588
40Sulfur metabolism_Homo sapiens_hsa009201.34339417
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.30240218
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28748927
43Steroid biosynthesis_Homo sapiens_hsa001001.22019879
44Folate biosynthesis_Homo sapiens_hsa007901.20177302
45ABC transporters_Homo sapiens_hsa020101.19869814
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18837670
47Fat digestion and absorption_Homo sapiens_hsa049751.15548540
48Carbon metabolism_Homo sapiens_hsa012001.11570931
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02096194
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.99424311
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98967821
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.97557718
53Arginine and proline metabolism_Homo sapiens_hsa003300.96148228
54Sulfur relay system_Homo sapiens_hsa041220.93951843
55Vitamin B6 metabolism_Homo sapiens_hsa007500.92923773
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86143805
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84446565
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82140374
59Lysine degradation_Homo sapiens_hsa003100.81452028
60One carbon pool by folate_Homo sapiens_hsa006700.75973347
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69578986
62Glycerolipid metabolism_Homo sapiens_hsa005610.67395295
63Glutathione metabolism_Homo sapiens_hsa004800.63059039
64Pentose phosphate pathway_Homo sapiens_hsa000300.56149758
65Fatty acid biosynthesis_Homo sapiens_hsa000610.54451113
66Metabolic pathways_Homo sapiens_hsa011000.45679830
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45506060
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39232427
69Prion diseases_Homo sapiens_hsa050200.34979099
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25335852
71Galactose metabolism_Homo sapiens_hsa000520.24702231
72Linoleic acid metabolism_Homo sapiens_hsa005910.23170559
73Insulin resistance_Homo sapiens_hsa049310.22839506
74Fructose and mannose metabolism_Homo sapiens_hsa000510.22300329
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.21438268
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20959935
77Pertussis_Homo sapiens_hsa051330.19614811
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.15539875
79Other glycan degradation_Homo sapiens_hsa005110.09747240
80Glucagon signaling pathway_Homo sapiens_hsa049220.09499741
81Serotonergic synapse_Homo sapiens_hsa047260.04782080
82Mineral absorption_Homo sapiens_hsa049780.03261160
83AMPK signaling pathway_Homo sapiens_hsa041520.01742339
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2449336
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2420601
86Amoebiasis_Homo sapiens_hsa05146-0.2415716
87Circadian rhythm_Homo sapiens_hsa04710-0.2407820
88Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2360392
89Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2257630
90N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2220252
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2067881
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1989264
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1971781
94Renin-angiotensin system_Homo sapiens_hsa04614-0.1945025
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1853588
96Hepatitis C_Homo sapiens_hsa05160-0.1822929
97Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1654247
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1638430
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1609957
100Type II diabetes mellitus_Homo sapiens_hsa04930-0.1599645
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1466350
102Regulation of autophagy_Homo sapiens_hsa04140-0.1359583
103African trypanosomiasis_Homo sapiens_hsa05143-0.1310927
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1048726
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0856459
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0850713
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0639746
108Sphingolipid metabolism_Homo sapiens_hsa00600-0.0537392
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0428612

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