SLAIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)5.46926932
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.43036561
3cardiac myofibril assembly (GO:0055003)4.95112530
4myofibril assembly (GO:0030239)4.52583213
5actin-myosin filament sliding (GO:0033275)4.51350890
6muscle filament sliding (GO:0030049)4.51350890
7negative regulation of potassium ion transmembrane transport (GO:1901380)4.42939209
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.37727652
9hypotonic response (GO:0006971)4.32347754
10carnitine shuttle (GO:0006853)4.23198084
11plasma membrane repair (GO:0001778)4.17405480
12actin-mediated cell contraction (GO:0070252)4.03188583
13carnitine transmembrane transport (GO:1902603)4.01977610
14cardiac muscle cell development (GO:0055013)3.91622600
15fatty acid transmembrane transport (GO:1902001)3.90617864
16desmosome organization (GO:0002934)3.90614639
17regulation of skeletal muscle contraction (GO:0014819)3.83155733
18carnitine transport (GO:0015879)3.82676309
19amino-acid betaine transport (GO:0015838)3.82676309
20cardiac cell development (GO:0055006)3.72124165
21actin filament-based movement (GO:0030048)3.48911058
22actomyosin structure organization (GO:0031032)3.47141822
23retrograde transport, vesicle recycling within Golgi (GO:0000301)3.41443754
24protein targeting to Golgi (GO:0000042)3.35928362
25regulation of sequestering of triglyceride (GO:0010889)3.28988772
26establishment of protein localization to Golgi (GO:0072600)3.20603299
27positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.19830949
28regulation of cardioblast differentiation (GO:0051890)3.18269985
29embryonic process involved in female pregnancy (GO:0060136)3.18013411
30tricarboxylic acid cycle (GO:0006099)3.15323196
31keratinization (GO:0031424)3.11910828
32cardiac muscle contraction (GO:0060048)3.11472811
33heart trabecula formation (GO:0060347)3.08265094
34positive regulation of histone deacetylation (GO:0031065)3.06830662
35ventricular cardiac muscle cell action potential (GO:0086005)3.06104959
36cytoplasmic mRNA processing body assembly (GO:0033962)3.03495302
37protein localization to endosome (GO:0036010)3.03174780
38skeletal muscle adaptation (GO:0043501)3.02072292
39skin morphogenesis (GO:0043589)3.00454154
40intracellular lipid transport (GO:0032365)2.97065478
41axonemal dynein complex assembly (GO:0070286)2.93581357
42epithelial cell-cell adhesion (GO:0090136)2.90423262
43cardiac muscle hypertrophy (GO:0003300)2.90119484
44monoubiquitinated protein deubiquitination (GO:0035520)2.90075043
45establishment of skin barrier (GO:0061436)2.89718461
46cardiac muscle tissue morphogenesis (GO:0055008)2.86641831
47hemidesmosome assembly (GO:0031581)2.80960214
48vascular endothelial growth factor signaling pathway (GO:0038084)2.80592695
49mitotic sister chromatid cohesion (GO:0007064)2.80154383
50regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.80045312
51striated muscle hypertrophy (GO:0014897)2.78573464
52regulation of p38MAPK cascade (GO:1900744)2.77284885
53sarcoplasmic reticulum calcium ion transport (GO:0070296)2.75996624
54regulation of NFAT protein import into nucleus (GO:0051532)2.75492434
55stress fiber assembly (GO:0043149)2.74969931
56regulation of water loss via skin (GO:0033561)2.74505961
57NLS-bearing protein import into nucleus (GO:0006607)2.71224813
58fusion of sperm to egg plasma membrane (GO:0007342)2.71158861
59striated muscle atrophy (GO:0014891)2.70894207
60macroautophagy (GO:0016236)2.70723942
61coronary vasculature morphogenesis (GO:0060977)2.68750724
62striated muscle contraction (GO:0006941)2.68644130
63quaternary ammonium group transport (GO:0015697)2.68288643
64regulation of fatty acid oxidation (GO:0046320)2.66891963
65negative regulation of heart growth (GO:0061117)2.66812382
66negative regulation of cardiac muscle tissue growth (GO:0055022)2.66812382
67muscle tissue morphogenesis (GO:0060415)2.65974123
68growth hormone receptor signaling pathway (GO:0060396)2.64010913
69regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.58218044
70heart process (GO:0003015)2.57418004
71heart contraction (GO:0060047)2.57418004
72ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.57165504
73glomerular visceral epithelial cell development (GO:0072015)2.56630685
74regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.55919542
75cilium or flagellum-dependent cell motility (GO:0001539)2.55725373
76interleukin-6-mediated signaling pathway (GO:0070102)2.55189904
77regulation of transforming growth factor beta2 production (GO:0032909)2.53289479
78regulation of sarcomere organization (GO:0060297)2.52226561
79positive regulation of myotube differentiation (GO:0010831)2.51589676
80mesodermal cell differentiation (GO:0048333)2.51222115
81negative regulation of protein localization to plasma membrane (GO:1903077)2.51109937
82regulation of actin filament-based movement (GO:1903115)2.49542268
83regulation of relaxation of muscle (GO:1901077)2.49422951
842-oxoglutarate metabolic process (GO:0006103)2.49392061
85motile cilium assembly (GO:0044458)2.48857100
86nuclear pore complex assembly (GO:0051292)2.48089587
87negative regulation of homotypic cell-cell adhesion (GO:0034111)2.47675546
88fibroblast migration (GO:0010761)2.47271216
89peptide cross-linking (GO:0018149)2.46524853
90muscle hypertrophy (GO:0014896)2.45928411
91negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.44783505
92cell adhesion mediated by integrin (GO:0033627)2.44743486
93interkinetic nuclear migration (GO:0022027)2.44319516
94positive thymic T cell selection (GO:0045059)2.42951686
95regulation of platelet aggregation (GO:0090330)2.42415226
96piRNA metabolic process (GO:0034587)2.42411301
97carnitine metabolic process (GO:0009437)2.40507044
98positive regulation of p38MAPK cascade (GO:1900745)2.38336053
99positive regulation of fatty acid oxidation (GO:0046321)2.38252697
100mRNA stabilization (GO:0048255)2.38020364
101RNA stabilization (GO:0043489)2.38020364
102positive regulation of fatty acid beta-oxidation (GO:0032000)2.37471570
103positive regulation of granulocyte differentiation (GO:0030854)2.37245070
104acrosome assembly (GO:0001675)2.36920804
105negative regulation of protein localization to cell surface (GO:2000009)2.36714714
106keratinocyte differentiation (GO:0030216)2.36440088
107cellular response to osmotic stress (GO:0071470)2.36383376
108cell-substrate junction assembly (GO:0007044)2.35356981
109striated muscle adaptation (GO:0014888)2.33058397
110histone H3-K9 demethylation (GO:0033169)2.31209842
111early endosome to late endosome transport (GO:0045022)2.31027131
112positive regulation of lipid storage (GO:0010884)2.30712896
113fatty acid beta-oxidation (GO:0006635)2.29737387
114negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.28696432
115regulation of RNA export from nucleus (GO:0046831)2.28647345
116valine metabolic process (GO:0006573)2.28446875
117creatine metabolic process (GO:0006600)2.28428428
118adult heart development (GO:0007512)2.28146037
119skeletal muscle contraction (GO:0003009)2.28110434
120cell migration involved in sprouting angiogenesis (GO:0002042)2.27861035
121positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.26790655
122negative regulation of cell size (GO:0045792)2.26391522
123myoblast fusion (GO:0007520)2.25750148
124striated muscle cell development (GO:0055002)2.25503777
125synaptonemal complex organization (GO:0070193)2.25254767
126positive regulation of blood vessel endothelial cell migration (GO:0043536)2.24470708
127thrombin receptor signaling pathway (GO:0070493)2.23306944
128seminiferous tubule development (GO:0072520)2.22561857
129synaptonemal complex assembly (GO:0007130)2.22009002
130cellular response to growth hormone stimulus (GO:0071378)2.21845697
131glomerular epithelial cell development (GO:0072310)2.20790999
132SMAD protein complex assembly (GO:0007183)2.18921785
133linoleic acid metabolic process (GO:0043651)2.17774335
134regulation of fatty acid beta-oxidation (GO:0031998)2.17713680
135definitive hemopoiesis (GO:0060216)2.16727209
136regulation of cAMP-dependent protein kinase activity (GO:2000479)2.16584736
137syncytium formation by plasma membrane fusion (GO:0000768)2.16195592
138antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.16065615
139protein localization to microtubule (GO:0035372)2.15455858
140positive regulation of T cell cytokine production (GO:0002726)2.15266972
141iron ion import (GO:0097286)2.14355708
142COPII vesicle coating (GO:0048208)2.13709216
143vesicle transport along microtubule (GO:0047496)2.13326244
144positive regulation of macrophage differentiation (GO:0045651)2.13094857
145positive regulation of Rho protein signal transduction (GO:0035025)2.13080072
146positive regulation of receptor recycling (GO:0001921)2.12775110
147relaxation of cardiac muscle (GO:0055119)2.12733212
148negative regulation of anoikis (GO:2000811)2.10828184
149peptide catabolic process (GO:0043171)2.07777142
150cellular response to thyroid hormone stimulus (GO:0097067)2.07244662
151cell-substrate adherens junction assembly (GO:0007045)2.06903331
152focal adhesion assembly (GO:0048041)2.06903331
153regulation of integrin-mediated signaling pathway (GO:2001044)2.06247940
154negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.04505299
155negative regulation of T-helper cell differentiation (GO:0045623)2.04505299
156negative regulation of necroptotic process (GO:0060546)2.02101967
157positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.01646245
158regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.01227516
159regulation of transforming growth factor beta1 production (GO:0032908)2.00777047
160negative regulation of fatty acid transport (GO:2000192)2.00622322
161regulation of tight junction assembly (GO:2000810)2.00278338
162regulation of lipoprotein metabolic process (GO:0050746)1.99480352
163negative regulation of norepinephrine secretion (GO:0010700)1.99213667
164negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)1.98215497
165receptor recycling (GO:0001881)1.97871855
166cellular response to arsenic-containing substance (GO:0071243)1.96655075
167protein localization to Golgi apparatus (GO:0034067)1.96629866
168pericardium development (GO:0060039)1.95884195
169skeletal muscle tissue regeneration (GO:0043403)1.95377282
170N-terminal protein amino acid acetylation (GO:0006474)1.94828911
171peptidyl-threonine modification (GO:0018210)1.93479441
172hippo signaling (GO:0035329)1.93450404
173peptidyl-threonine phosphorylation (GO:0018107)1.92756273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.70836169
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.56753206
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.99699206
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.73103950
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.62202333
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50153855
7* TBX20_22328084_ChIP-Seq_HEART_Mouse2.40149780
8* TBX20_22080862_ChIP-Seq_HEART_Mouse2.40149780
9* EP300_21415370_ChIP-Seq_HL-1_Mouse2.38703117
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34316852
11ZNF263_19887448_ChIP-Seq_K562_Human2.28925328
12CLOCK_20551151_ChIP-Seq_293T_Human2.15851090
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.10498030
14FOXO3_23340844_ChIP-Seq_DLD1_Human2.03410516
15WT1_19549856_ChIP-ChIP_CCG9911_Human1.99067581
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94731639
17GATA1_22025678_ChIP-Seq_K562_Human1.93201719
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87851610
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.85998303
20LXR_22158963_ChIP-Seq_LIVER_Mouse1.85553983
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.80502475
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.79504568
23* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.77455843
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76881339
25TCF7_22412390_ChIP-Seq_EML_Mouse1.76164842
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74499980
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71596387
28SOX9_24532713_ChIP-Seq_HFSC_Mouse1.69527032
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68440578
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.61823582
31* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60420149
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.59513060
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59279424
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59279424
35* TP63_23658742_ChIP-Seq_EP156T_Human1.58397738
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.58303219
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57603975
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57501900
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56785314
40* CJUN_26792858_Chip-Seq_BT549_Human1.54806159
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50702229
42* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50142286
43* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.49942561
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.48725901
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48673297
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.47075685
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46954181
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46153864
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.45338300
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44797217
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44259978
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44259978
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43865202
54FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.43350581
55AHR_22903824_ChIP-Seq_MCF-7_Human1.40186210
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39328107
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38263697
58* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38048843
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.37995854
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36842906
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36511901
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36216444
63FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35905171
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35538325
65NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.33561228
66* RUNX1_27514584_Chip-Seq_MCF-7_Human1.32780903
67* PIAS1_25552417_ChIP-Seq_VCAP_Human1.30673276
68TP53_18474530_ChIP-ChIP_U2OS_Human1.30417696
69* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28711213
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28445247
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28019235
72ATF3_27146783_Chip-Seq_COLON_Human1.27751123
73GATA6_25053715_ChIP-Seq_YYC3_Human1.27703820
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27097768
75KDM2B_26808549_Chip-Seq_DND41_Human1.26944184
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.26286297
77MAF_26560356_Chip-Seq_TH1_Human1.25621554
78GATA2_19941826_ChIP-Seq_K562_Human1.25261352
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25119529
80PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.24374502
81SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23967810
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23136969
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23065244
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.23008488
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22976643
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22618905
87BP1_19119308_ChIP-ChIP_Hs578T_Human1.21622856
88* BRD4_25478319_ChIP-Seq_HGPS_Human1.21191458
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21095675
90GATA1_19941826_ChIP-Seq_K562_Human1.18771258
91MYB_26560356_Chip-Seq_TH2_Human1.18106867
92SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17247536
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.16400088
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16035670
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15331516
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15153710
97SMAD4_21799915_ChIP-Seq_A2780_Human1.15062384
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13021231
99GATA4_25053715_ChIP-Seq_YYC3_Human1.12876862
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11816841
101TP53_16413492_ChIP-PET_HCT116_Human1.11141720
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10057562
103UTX_26944678_Chip-Seq_JUKART_Human1.09919381
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.08321230
105FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08290187
106FOXA2_19822575_ChIP-Seq_HepG2_Human1.08197429
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08152049
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07916978
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07563349
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07295671
111ELK3_25401928_ChIP-Seq_HUVEC_Human1.06910488
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06074048
113VDR_24787735_ChIP-Seq_THP-1_Human1.05626771
114* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03983586
115MYB_26560356_Chip-Seq_TH1_Human1.03582763
116MYC_22102868_ChIP-Seq_BL_Human1.03475689
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03464476
118* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03125736
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01716970
120NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01370809
121* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01020207
122CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99997382
123TAF15_26573619_Chip-Seq_HEK293_Human0.98820870
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98077703
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97548340
126* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97095206
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96989286
128RXR_22108803_ChIP-Seq_LS180_Human0.96812078
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96630273
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.96280955
131KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95954669
132PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94434377
133* GATA3_27048872_Chip-Seq_THYMUS_Human0.94042704
134* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93762891
135RUNX_20019798_ChIP-Seq_JUKART_Human0.93744825
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92903441
137SPI1_23127762_ChIP-Seq_K562_Human0.92554902
138* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92514900
139GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90040880
140SOX2_20726797_ChIP-Seq_SW620_Human0.88460583
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87990719
142* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87455751
143* CDX2_22108803_ChIP-Seq_LS180_Human0.86493747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle3.56592891
2MP0002837_dystrophic_cardiac_calcinosis3.48560861
3MP0003646_muscle_fatigue3.46448547
4MP0000751_myopathy2.80227265
5MP0004036_abnormal_muscle_relaxation2.53368768
6MP0003705_abnormal_hypodermis_morpholog2.29516654
7MP0005464_abnormal_platelet_physiology2.28528744
8MP0004215_abnormal_myocardial_fiber2.28206115
9MP0004087_abnormal_muscle_fiber2.25374535
10MP0000750_abnormal_muscle_regeneration2.21428208
11MP0004185_abnormal_adipocyte_glucose2.16581520
12MP0004130_abnormal_muscle_cell2.16269143
13MP0005330_cardiomyopathy2.13715219
14MP0000749_muscle_degeneration2.13269941
15MP0010630_abnormal_cardiac_muscle2.06524180
16MP0009780_abnormal_chondrocyte_physiolo2.05416414
17MP0003828_pulmonary_edema1.95038715
18MP0003566_abnormal_cell_adhesion1.93077150
19MP0005666_abnormal_adipose_tissue1.84901536
20MP0005409_darkened_coat_color1.83391843
21MP0008004_abnormal_stomach_pH1.83176921
22MP0002106_abnormal_muscle_physiology1.80939222
23MP0002877_abnormal_melanocyte_morpholog1.79095819
24MP0002972_abnormal_cardiac_muscle1.76939603
25MP0008775_abnormal_heart_ventricle1.72839482
26MP0005385_cardiovascular_system_phenoty1.69318701
27MP0001544_abnormal_cardiovascular_syste1.69318701
28MP0003300_gastrointestinal_ulcer1.66761413
29MP0005670_abnormal_white_adipose1.65293423
30MP0004510_myositis1.62832899
31MP0005620_abnormal_muscle_contractility1.61497312
32MP0002332_abnormal_exercise_endurance1.61040045
33MP0010352_gastrointestinal_tract_polyps1.51772277
34MP0003656_abnormal_erythrocyte_physiolo1.50138800
35MP0006138_congestive_heart_failure1.49994223
36MP0003221_abnormal_cardiomyocyte_apopto1.49229347
37MP0000465_gastrointestinal_hemorrhage1.49070029
38MP0002269_muscular_atrophy1.48295853
39MP0004484_altered_response_of1.44096215
40MP0005275_abnormal_skin_tensile1.42620708
41MP0005501_abnormal_skin_physiology1.41774527
42MP0005076_abnormal_cell_differentiation1.38820761
43MP0005369_muscle_phenotype1.37399970
44MP0005410_abnormal_fertilization1.37285927
45MP0000759_abnormal_skeletal_muscle1.33917380
46MP0000733_abnormal_muscle_development1.30789896
47MP0002998_abnormal_bone_remodeling1.30140234
48MP0010678_abnormal_skin_adnexa1.29781867
49MP0001348_abnormal_lacrimal_gland1.28650881
50MP0003567_abnormal_fetal_cardiomyocyte1.28129167
51MP0003724_increased_susceptibility_to1.27831203
52MP0005375_adipose_tissue_phenotype1.27788646
53MP0010234_abnormal_vibrissa_follicle1.27435190
54MP0004272_abnormal_basement_membrane1.24993073
55MP0010368_abnormal_lymphatic_system1.24796504
56MP0004145_abnormal_muscle_electrophysio1.24124080
57MP0004883_abnormal_blood_vessel1.22961014
58MP0005164_abnormal_response_to1.21759804
59MP0002796_impaired_skin_barrier1.18165724
60MP0005451_abnormal_body_composition1.16486659
61MP0004233_abnormal_muscle_weight1.15720798
62MP0000747_muscle_weakness1.15415797
63MP0000569_abnormal_digit_pigmentation1.14456217
64MP0001958_emphysema1.13405362
65MP0003950_abnormal_plasma_membrane1.12844644
66MP0001849_ear_inflammation1.11879480
67MP0000383_abnormal_hair_follicle1.11875128
68MP0001542_abnormal_bone_strength1.11213370
69MP0002166_altered_tumor_susceptibility1.09362039
70MP0005310_abnormal_salivary_gland1.04601944
71MP0000249_abnormal_blood_vessel1.03518921
72MP0000858_altered_metastatic_potential1.03277091
73MP0000266_abnormal_heart_morphology1.01218642
74MP0002060_abnormal_skin_morphology1.01092169
75MP0001879_abnormal_lymphatic_vessel0.99748856
76MP0003279_aneurysm0.98419281
77MP0009384_cardiac_valve_regurgitation0.97917288
78MP0000343_altered_response_to0.96606639
79MP0005623_abnormal_meninges_morphology0.96190120
80MP0000767_abnormal_smooth_muscle0.94685868
81MP0009053_abnormal_anal_canal0.93873124
82MP0003137_abnormal_impulse_conducting0.92561997
83MP0003252_abnormal_bile_duct0.91627623
84MP0003045_fibrosis0.91420922
85MP0001533_abnormal_skeleton_physiology0.90966996
86MP0003453_abnormal_keratinocyte_physiol0.90719081
87MP0004947_skin_inflammation0.89320686
88MP0001851_eye_inflammation0.87681985
89MP0002971_abnormal_brown_adipose0.87021055
90MP0002128_abnormal_blood_circulation0.86360127
91MP0008438_abnormal_cutaneous_collagen0.84016093
92MP0002925_abnormal_cardiovascular_devel0.83998543
93MP0003191_abnormal_cellular_cholesterol0.83507819
94MP0008961_abnormal_basal_metabolism0.82521976
95MP0009278_abnormal_bone_marrow0.81137166
96MP0003091_abnormal_cell_migration0.80514587
97MP0003763_abnormal_thymus_physiology0.79965079
98MP0002009_preneoplasia0.79837117
99MP0000003_abnormal_adipose_tissue0.79430095
100MP0000427_abnormal_hair_cycle0.79132099
101MP0003303_peritoneal_inflammation0.78799029
102MP0003183_abnormal_peptide_metabolism0.78519129
103MP0001216_abnormal_epidermal_layer0.78043793
104MP0002088_abnormal_embryonic_growth/wei0.76043784
105MP0005503_abnormal_tendon_morphology0.75827525
106MP0003984_embryonic_growth_retardation0.75724777
107MP0002006_tumorigenesis0.74961199
108MP0004085_abnormal_heartbeat0.74835357
109MP0005187_abnormal_penis_morphology0.74731411
110MP0002127_abnormal_cardiovascular_syste0.74321043
111MP0005058_abnormal_lysosome_morphology0.72568862
112MP0005023_abnormal_wound_healing0.72503373
113MP0004134_abnormal_chest_morphology0.70799129
114MP0001784_abnormal_fluid_regulation0.69709569
115MP0001915_intracranial_hemorrhage0.69323007
116MP0003941_abnormal_skin_development0.68368119
117MP0002138_abnormal_hepatobiliary_system0.67260619
118MP0002234_abnormal_pharynx_morphology0.66944585
119MP0004808_abnormal_hematopoietic_stem0.66442873
120MP0002896_abnormal_bone_mineralization0.63778771
121MP0003448_altered_tumor_morphology0.63243707
122MP0001614_abnormal_blood_vessel0.62891109
123MP0001672_abnormal_embryogenesis/_devel0.62488652
124MP0005380_embryogenesis_phenotype0.62488652
125MP0009115_abnormal_fat_cell0.60640034
126MP0002108_abnormal_muscle_morphology0.60203543
127MP0000579_abnormal_nail_morphology0.59887168
128MP0002086_abnormal_extraembryonic_tissu0.59591388

Predicted human phenotypes

RankGene SetZ-score
1Ventricular tachycardia (HP:0004756)5.41111242
2Right ventricular cardiomyopathy (HP:0011663)5.34041388
3Sudden death (HP:0001699)5.31671527
4Hyporeflexia of lower limbs (HP:0002600)5.23143371
5Exercise-induced muscle cramps (HP:0003710)5.07924390
6Exercise-induced myalgia (HP:0003738)4.89786930
7Muscle fiber splitting (HP:0003555)4.73957151
8Calf muscle hypertrophy (HP:0008981)4.48151878
9Abnormality of the left ventricular outflow tract (HP:0011103)4.34558321
10Subaortic stenosis (HP:0001682)4.34558321
11Increased connective tissue (HP:0009025)4.26773600
12Muscle hypertrophy of the lower extremities (HP:0008968)4.13344585
13Myoglobinuria (HP:0002913)3.78920567
14Lipoatrophy (HP:0100578)3.76039032
15Abnormality of the calf musculature (HP:0001430)3.68953374
16Atrial fibrillation (HP:0005110)3.61219332
17Difficulty running (HP:0009046)3.60189349
18Asymmetric septal hypertrophy (HP:0001670)3.54056460
19Increased mean platelet volume (HP:0011877)3.46661626
20Primary atrial arrhythmia (HP:0001692)3.39134662
21Muscle fiber inclusion bodies (HP:0100299)3.30941147
22Type 1 muscle fiber predominance (HP:0003803)3.29279321
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.27076447
24Abnormal platelet volume (HP:0011876)3.26001252
25Rhabdomyolysis (HP:0003201)3.20616485
26Supraventricular tachycardia (HP:0004755)3.17038389
27EMG: myopathic abnormalities (HP:0003458)3.15942895
28Supraventricular arrhythmia (HP:0005115)3.15172678
29Difficulty climbing stairs (HP:0003551)3.08488323
30Vascular tortuosity (HP:0004948)3.05522233
31Bundle branch block (HP:0011710)3.05377491
32Dilated cardiomyopathy (HP:0001644)3.03917719
33Arterial tortuosity (HP:0005116)3.03258787
34Hypoplastic ischia (HP:0003175)2.91341250
35Papillary thyroid carcinoma (HP:0002895)2.91223625
36Menorrhagia (HP:0000132)2.88689578
37Prolonged bleeding time (HP:0003010)2.80363499
38Aortic dissection (HP:0002647)2.64425468
39Syncope (HP:0001279)2.62284687
40Nemaline bodies (HP:0003798)2.61187642
41Abnormality of the ischium (HP:0003174)2.58524478
42Ventricular arrhythmia (HP:0004308)2.53176116
43Thin bony cortex (HP:0002753)2.48759916
44Areflexia of lower limbs (HP:0002522)2.44828967
45Hyperglycemia (HP:0003074)2.40568644
46Palpitations (HP:0001962)2.39606873
47Abnormal atrioventricular conduction (HP:0005150)2.39403211
48Insulin-resistant diabetes mellitus (HP:0000831)2.38031708
49Lower limb amyotrophy (HP:0007210)2.36689753
50Thick nail (HP:0001805)2.36174137
51Atrioventricular block (HP:0001678)2.35942032
52Heart block (HP:0012722)2.35548289
53Hematochezia (HP:0002573)2.33800304
54Distal lower limb muscle weakness (HP:0009053)2.29595223
55Protrusio acetabuli (HP:0003179)2.28848437
56Facial diplegia (HP:0001349)2.27354103
57Gingival bleeding (HP:0000225)2.25169141
58Hypoglycemic coma (HP:0001325)2.24636324
59Ulnar deviation of the wrist (HP:0003049)2.22213306
60Abnormality of skeletal muscle fiber size (HP:0012084)2.20018817
61Abnormality of the nasal mucosa (HP:0000433)2.19148988
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.17368068
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.16657461
64Absent/shortened dynein arms (HP:0200106)2.16657461
65Increased variability in muscle fiber diameter (HP:0003557)2.16057922
66Neck muscle weakness (HP:0000467)2.15777766
67Rectal prolapse (HP:0002035)2.15758128
68EMG: neuropathic changes (HP:0003445)2.12972853
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.10811792
70Osteolytic defects of the hand bones (HP:0009699)2.10811792
71Nasal polyposis (HP:0100582)2.07816325
72Spontaneous hematomas (HP:0007420)2.07716512
73Mildly elevated creatine phosphokinase (HP:0008180)2.06992619
74Frequent falls (HP:0002359)2.04712621
75Spondylolisthesis (HP:0003302)2.04097430
76Atrophic scars (HP:0001075)1.99965823
77Round ear (HP:0100830)1.99385045
78Epistaxis (HP:0000421)1.99113504
79Conjunctival hamartoma (HP:0100780)1.98693838
80Aneurysm (HP:0002617)1.98402060
81Hypoalphalipoproteinemia (HP:0003233)1.96264424
82Male infertility (HP:0003251)1.95753072
83Purpura (HP:0000979)1.94188358
84Polycythemia (HP:0001901)1.92854817
85Subacute progressive viral hepatitis (HP:0006572)1.91894151
86Scapular winging (HP:0003691)1.91174148
87Rhinitis (HP:0012384)1.90331710
88Curly hair (HP:0002212)1.89713094
89Muscle stiffness (HP:0003552)1.89700361
90Lymphangioma (HP:0100764)1.89304471
91Abnormality of the fingertips (HP:0001211)1.88795401
92Hyperlipoproteinemia (HP:0010980)1.88262470
93Cerebral aneurysm (HP:0004944)1.88259702
94Myotonia (HP:0002486)1.87670151
95Palmoplantar keratoderma (HP:0000982)1.87313119
96Premature rupture of membranes (HP:0001788)1.87037475
97Absent phalangeal crease (HP:0006109)1.86630266
98Progressive hearing impairment (HP:0001730)1.85757065
99Distal arthrogryposis (HP:0005684)1.85466239
100Aortic aneurysm (HP:0004942)1.83054701
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82894352
102Increased IgE level (HP:0003212)1.82758343
103Abnormal ciliary motility (HP:0012262)1.81811596
104Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81640141
105Hamartoma of the eye (HP:0010568)1.81631654
106Abnormal respiratory motile cilium physiology (HP:0012261)1.81295857
107Abnormality of nail color (HP:0100643)1.81152436
108Abnormal respiratory epithelium morphology (HP:0012253)1.80944181
109Abnormal respiratory motile cilium morphology (HP:0005938)1.80944181
110Prolonged QT interval (HP:0001657)1.79663061
111Generalized muscle weakness (HP:0003324)1.78655057
112Hyperkalemia (HP:0002153)1.78586546
113Limb-girdle muscle atrophy (HP:0003797)1.77923637
114Ketoacidosis (HP:0001993)1.77749043
115Increased density of long bones (HP:0006392)1.77625218
116Rimmed vacuoles (HP:0003805)1.77186229
117Spinal rigidity (HP:0003306)1.76895201
118Flat acetabular roof (HP:0003180)1.75970084
119Myocardial infarction (HP:0001658)1.72719835
120Sudden cardiac death (HP:0001645)1.72441208
121Proximal amyotrophy (HP:0007126)1.69559484
122Absent frontal sinuses (HP:0002688)1.69358266
123Hip contracture (HP:0003273)1.68416132
124Ventricular fibrillation (HP:0001663)1.67425575
125Myopathic facies (HP:0002058)1.67078828
126Wormian bones (HP:0002645)1.66616777
127Malignant hyperthermia (HP:0002047)1.66112221
128Mitral stenosis (HP:0001718)1.65385190
129Onycholysis (HP:0001806)1.65317900
130Back pain (HP:0003418)1.63387105
131Petechiae (HP:0000967)1.63332145
132Termporal pattern (HP:0011008)1.63003700
133Insidious onset (HP:0003587)1.63003700
134Gowers sign (HP:0003391)1.62745324
135Metaphyseal cupping (HP:0003021)1.61706477
136Lip pit (HP:0100267)1.61576686
137Toxemia of pregnancy (HP:0100603)1.61161912
138Distal lower limb amyotrophy (HP:0008944)1.60938094
139Abnormal finger flexion creases (HP:0006143)1.60083561
140Cranial hyperostosis (HP:0004437)1.58172103
141Thyroid carcinoma (HP:0002890)1.57488616
142Neonatal death (HP:0003811)1.57237329
143Muscular dystrophy (HP:0003560)1.56874422
144Progressive sensorineural hearing impairment (HP:0000408)1.56716157
145Fatigable weakness (HP:0003473)1.56270060
146Abnormality of the neuromuscular junction (HP:0003398)1.56270060
147Portal hypertension (HP:0001409)1.55103807
148Ankle contracture (HP:0006466)1.53569228
149Dilatation of the ascending aorta (HP:0005111)1.53068186
150Fragile skin (HP:0001030)1.52148625
151Slender build (HP:0001533)1.51461655
152Coarse hair (HP:0002208)1.49911046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.07494161
2TRIB33.32381642
3PDK43.28455854
4PDK33.28455854
5LATS13.13829894
6OBSCN2.69841441
7DMPK2.54924426
8PKN22.54573582
9PDK22.49637624
10STK242.27825721
11AKT32.05629851
12CDK121.91802334
13STK31.91344609
14NEK91.75871204
15PNCK1.72537191
16MAP3K31.51092451
17MST1R1.46930598
18MAP3K101.46818586
19PTK61.43371667
20PHKG21.42598906
21PHKG11.42598906
22RIPK11.41432650
23STK38L1.38770890
24IRAK11.37621160
25MOS1.36162856
26EEF2K1.35459989
27SGK31.34066308
28LMTK21.28972603
29ERN11.28618396
30MAP2K31.26051351
31PIK3CA1.25606967
32EPHB11.22352152
33IRAK21.22340903
34STK101.21091228
35EPHA31.21020551
36PRKD31.19150098
37FRK1.18616228
38SGK21.16189467
39MAP3K121.15522384
40WNK41.15389931
41TESK11.13391624
42TGFBR21.12987078
43MYLK1.09582770
44TYK21.08188226
45ERBB31.06390937
46MAP3K21.04972250
47BRD41.04327875
48ARAF1.04030517
49PDGFRA1.01225746
50KSR21.00560848
51CDK61.00196180
52TIE10.99685245
53MAPKAPK30.98851667
54PRPF4B0.98016108
55ICK0.97568892
56FGFR30.97130513
57MARK20.95397247
58MAP3K140.94802397
59TRPM70.94075112
60FGFR40.90685356
61MAP3K10.89402220
62MAP3K60.88818005
63MAP3K50.88280105
64RAF10.87306931
65KSR10.85421911
66EPHA20.84544243
67JAK10.83524375
68NEK20.82730007
69MTOR0.81840359
70DDR20.81611770
71CDK90.81398604
72LRRK20.81279467
73LATS20.80928003
74PRKAA20.79353068
75ILK0.78628822
76SIK10.77147513
77TAOK30.75802028
78RPS6KA40.75319334
79PDGFRB0.74621391
80MAP4K10.74322371
81PTK2B0.73220146
82RPS6KA20.72831925
83CDC42BPA0.72788373
84BCKDK0.71839764
85PRKAA10.71002260
86MARK30.68642966
87PRKD10.68280362
88YES10.68138651
89EIF2AK10.68092482
90FLT30.67246258
91MST40.65396919
92BMX0.65187561
93ZAP700.64604428
94SGK2230.63544504
95SGK4940.63544504
96MAP2K10.62724920
97CAMK1D0.62682283
98SIK30.62597889
99JAK30.62298829
100ITK0.61652889
101STK40.60579345
102RIPK40.60494652
103WNK10.59869386
104MAP3K70.58948734
105DYRK1B0.58602688
106PAK40.56463772
107IRAK30.56173692
108PIM20.56129643
109PIK3CG0.56003543
110BMPR20.54754549
111LIMK10.53806044
112INSRR0.53733331
113MAPK70.53217259
114MAPK120.53181481
115TGFBR10.53086261
116TAOK10.53006688
117MAP3K130.52375446
118PLK40.52109777
119CDK40.49734085
120CAMKK20.49702560
121JAK20.48839480
122BRSK20.48583102
123EPHB20.48569520
124CDK30.47230418
125CHUK0.47189280
126BCR0.46058042
127NEK10.45736528
128PAK30.44388189
129TBK10.44330095
130PAK20.43136795
131CAMK1G0.42864760
132PDK10.42034186
133MET0.41740519
134RPS6KB20.40435643
135KDR0.40195057
136CSK0.38307210
137PTK20.37796269
138GSK3A0.37542784
139RET0.37451867
140ROCK10.36672064
141PDPK10.35585516
142RPS6KA10.34918445
143FER0.33873146
144STK380.33784726
145TTK0.31885889

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.07074485
2Fatty acid degradation_Homo sapiens_hsa000712.58924786
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.57849406
4Propanoate metabolism_Homo sapiens_hsa006402.48017666
5Dilated cardiomyopathy_Homo sapiens_hsa054142.35301761
6Viral myocarditis_Homo sapiens_hsa054162.32072532
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.10131317
8Insulin resistance_Homo sapiens_hsa049311.87237754
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84319007
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72804674
11Adherens junction_Homo sapiens_hsa045201.70838762
12Fatty acid metabolism_Homo sapiens_hsa012121.61964078
13Lysine degradation_Homo sapiens_hsa003101.57878696
14Focal adhesion_Homo sapiens_hsa045101.51192525
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50684449
16PPAR signaling pathway_Homo sapiens_hsa033201.49796477
17Adipocytokine signaling pathway_Homo sapiens_hsa049201.41884613
18Dorso-ventral axis formation_Homo sapiens_hsa043201.40580363
19Toxoplasmosis_Homo sapiens_hsa051451.40332255
20Small cell lung cancer_Homo sapiens_hsa052221.38152514
21Sulfur metabolism_Homo sapiens_hsa009201.35707627
22Starch and sucrose metabolism_Homo sapiens_hsa005001.34913461
23ECM-receptor interaction_Homo sapiens_hsa045121.29201811
24Carbon metabolism_Homo sapiens_hsa012001.27808645
25Glucagon signaling pathway_Homo sapiens_hsa049221.26278453
26ErbB signaling pathway_Homo sapiens_hsa040121.20838843
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.19251623
28AMPK signaling pathway_Homo sapiens_hsa041521.16694055
29Osteoclast differentiation_Homo sapiens_hsa043801.14419982
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.11001628
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10922067
32Amoebiasis_Homo sapiens_hsa051461.07702811
33Thyroid cancer_Homo sapiens_hsa052161.06799708
34Pyruvate metabolism_Homo sapiens_hsa006201.06407877
35Insulin signaling pathway_Homo sapiens_hsa049101.05731828
36Proteoglycans in cancer_Homo sapiens_hsa052051.05522884
37Cardiac muscle contraction_Homo sapiens_hsa042601.04060018
38Choline metabolism in cancer_Homo sapiens_hsa052311.02218012
39Chemokine signaling pathway_Homo sapiens_hsa040621.01095520
40Endocytosis_Homo sapiens_hsa041441.00989156
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00798468
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98905344
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.97653574
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97275411
45MicroRNAs in cancer_Homo sapiens_hsa052060.96959975
46Chronic myeloid leukemia_Homo sapiens_hsa052200.96737155
47mTOR signaling pathway_Homo sapiens_hsa041500.95357847
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95011842
49Fatty acid biosynthesis_Homo sapiens_hsa000610.93847108
50Colorectal cancer_Homo sapiens_hsa052100.91359478
51Pancreatic cancer_Homo sapiens_hsa052120.91358976
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90465357
53Inositol phosphate metabolism_Homo sapiens_hsa005620.89848467
54VEGF signaling pathway_Homo sapiens_hsa043700.88413348
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87988222
56Leishmaniasis_Homo sapiens_hsa051400.87744766
57GnRH signaling pathway_Homo sapiens_hsa049120.87399344
58Caffeine metabolism_Homo sapiens_hsa002320.86943279
59Renal cell carcinoma_Homo sapiens_hsa052110.85785807
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.85412298
61Tryptophan metabolism_Homo sapiens_hsa003800.84787361
62Hematopoietic cell lineage_Homo sapiens_hsa046400.83638259
63B cell receptor signaling pathway_Homo sapiens_hsa046620.83609091
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81444272
65Glioma_Homo sapiens_hsa052140.81428562
66Gap junction_Homo sapiens_hsa045400.81242979
67MAPK signaling pathway_Homo sapiens_hsa040100.80979882
68Fat digestion and absorption_Homo sapiens_hsa049750.80269108
69Bladder cancer_Homo sapiens_hsa052190.80165716
70Platelet activation_Homo sapiens_hsa046110.79301663
71Malaria_Homo sapiens_hsa051440.78979963
72Hepatitis C_Homo sapiens_hsa051600.78195568
73Tight junction_Homo sapiens_hsa045300.78175441
74TGF-beta signaling pathway_Homo sapiens_hsa043500.76995967
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.75824968
76FoxO signaling pathway_Homo sapiens_hsa040680.74654722
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74305480
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74007617
79Acute myeloid leukemia_Homo sapiens_hsa052210.73672906
80Selenocompound metabolism_Homo sapiens_hsa004500.73646183
81HIF-1 signaling pathway_Homo sapiens_hsa040660.72670653
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.72421616
83Antigen processing and presentation_Homo sapiens_hsa046120.71368640
84Long-term depression_Homo sapiens_hsa047300.70961916
85TNF signaling pathway_Homo sapiens_hsa046680.70748958
86Melanoma_Homo sapiens_hsa052180.69775038
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.69761513
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.69738070
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69512076
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69364367
91Renin secretion_Homo sapiens_hsa049240.69117323
92Estrogen signaling pathway_Homo sapiens_hsa049150.67314162
93Prolactin signaling pathway_Homo sapiens_hsa049170.67202207
94Shigellosis_Homo sapiens_hsa051310.66740925
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66642383
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65995889
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65423211
98Prostate cancer_Homo sapiens_hsa052150.65319566
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65261036
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65219869
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65019837
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64460117
103Long-term potentiation_Homo sapiens_hsa047200.63482407
104Legionellosis_Homo sapiens_hsa051340.63396249
105p53 signaling pathway_Homo sapiens_hsa041150.62723405
106Protein digestion and absorption_Homo sapiens_hsa049740.62560358
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62337903
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60726847
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60249622
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59775221
111Herpes simplex infection_Homo sapiens_hsa051680.59593437
112beta-Alanine metabolism_Homo sapiens_hsa004100.59219724
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58584040
114Influenza A_Homo sapiens_hsa051640.58435109
115Endometrial cancer_Homo sapiens_hsa052130.58169588
116Measles_Homo sapiens_hsa051620.58108801
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58012927
118Rap1 signaling pathway_Homo sapiens_hsa040150.57506431
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57480946
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57422938
121Glycerolipid metabolism_Homo sapiens_hsa005610.55578517
122Ras signaling pathway_Homo sapiens_hsa040140.55377988
123Pancreatic secretion_Homo sapiens_hsa049720.55108325
124HTLV-I infection_Homo sapiens_hsa051660.54499441
125Oxytocin signaling pathway_Homo sapiens_hsa049210.53438453
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53021881
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52923072
128Salmonella infection_Homo sapiens_hsa051320.52670397
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51225398
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49731621
131Viral carcinogenesis_Homo sapiens_hsa052030.49640466
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49199067
133Apoptosis_Homo sapiens_hsa042100.49098040
134Hepatitis B_Homo sapiens_hsa051610.48966603
135Staphylococcus aureus infection_Homo sapiens_hsa051500.48801845
136Type II diabetes mellitus_Homo sapiens_hsa049300.48262643
137Circadian rhythm_Homo sapiens_hsa047100.47568268
138Notch signaling pathway_Homo sapiens_hsa043300.46739939
139Non-small cell lung cancer_Homo sapiens_hsa052230.45558915
140T cell receptor signaling pathway_Homo sapiens_hsa046600.44211839
141Pathways in cancer_Homo sapiens_hsa052000.43158415

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