SLA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.40980110
2negative regulation of cell killing (GO:0031342)5.58145500
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.58145500
4negative T cell selection (GO:0043383)5.46662065
5regulation of gamma-delta T cell differentiation (GO:0045586)5.36755881
6regulation of B cell receptor signaling pathway (GO:0050855)5.13516207
7negative thymic T cell selection (GO:0045060)5.12202072
8leukocyte aggregation (GO:0070486)5.06681076
9positive thymic T cell selection (GO:0045059)5.02479546
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.00226908
11regulation of gamma-delta T cell activation (GO:0046643)4.99265659
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.97297029
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.97297029
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.85386433
15positive T cell selection (GO:0043368)4.80699517
16antigen processing and presentation of endogenous antigen (GO:0019883)4.68667309
17interferon-gamma production (GO:0032609)4.65414252
18tolerance induction (GO:0002507)4.57202677
19regulation of isotype switching to IgG isotypes (GO:0048302)4.53332520
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.52528802
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.41416787
22response to interleukin-15 (GO:0070672)4.37203394
23T cell selection (GO:0045058)4.36058234
24regulation of interleukin-12 biosynthetic process (GO:0045075)4.29048911
25thymic T cell selection (GO:0045061)4.24625283
26cellular response to interleukin-15 (GO:0071350)4.16547349
27detection of other organism (GO:0098543)4.14010953
28activated T cell proliferation (GO:0050798)4.13141105
29regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.01232889
30neutrophil activation (GO:0042119)4.00086815
31regulation of B cell differentiation (GO:0045577)3.97133200
32T cell migration (GO:0072678)3.95565449
33detection of bacterium (GO:0016045)3.89097186
34mast cell activation (GO:0045576)3.85812765
35granulocyte activation (GO:0036230)3.84181595
36macrophage activation involved in immune response (GO:0002281)3.83219298
37positive regulation of B cell differentiation (GO:0045579)3.82404760
38response to peptidoglycan (GO:0032494)3.79413686
39B cell receptor signaling pathway (GO:0050853)3.78670389
40regulation of regulatory T cell differentiation (GO:0045589)3.76667041
41T cell costimulation (GO:0031295)3.73556858
42positive regulation of isotype switching (GO:0045830)3.72270533
43lymphocyte costimulation (GO:0031294)3.70649234
44T cell receptor signaling pathway (GO:0050852)3.66973681
45antigen receptor-mediated signaling pathway (GO:0050851)3.63882547
46detection of external biotic stimulus (GO:0098581)3.61960941
47detection of molecule of bacterial origin (GO:0032490)3.60229482
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.59918025
49negative regulation of leukocyte mediated immunity (GO:0002704)3.58481317
50regulation of alpha-beta T cell proliferation (GO:0046640)3.56364489
51regulation of tolerance induction (GO:0002643)3.55812117
52regulation of interleukin-2 biosynthetic process (GO:0045076)3.53444251
53myeloid dendritic cell activation (GO:0001773)3.53126525
54positive regulation of immunoglobulin mediated immune response (GO:0002891)3.45828487
55positive regulation of B cell mediated immunity (GO:0002714)3.45828487
56regulation of interferon-beta biosynthetic process (GO:0045357)3.39704995
57dendritic cell chemotaxis (GO:0002407)3.39329289
58myeloid cell activation involved in immune response (GO:0002275)3.36285106
59microglial cell activation (GO:0001774)3.36178058
60negative regulation of interleukin-12 production (GO:0032695)3.33209266
61positive regulation of interleukin-2 production (GO:0032743)3.32861955
62positive regulation of alpha-beta T cell proliferation (GO:0046641)3.32729291
63negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.31461349
64positive regulation of tolerance induction (GO:0002645)3.30358942
65T cell homeostasis (GO:0043029)3.28343506
66regulation of isotype switching (GO:0045191)3.28262728
67Arp2/3 complex-mediated actin nucleation (GO:0034314)3.28117154
68detection of biotic stimulus (GO:0009595)3.27299340
69leukocyte cell-cell adhesion (GO:0007159)3.26448671
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.24819082
71dendritic cell migration (GO:0036336)3.24149619
72regulation of B cell mediated immunity (GO:0002712)3.24136231
73regulation of T cell tolerance induction (GO:0002664)3.22715001
74regulation of immunoglobulin mediated immune response (GO:0002889)3.22561115
75regulation of natural killer cell mediated immunity (GO:0002715)3.22552548
76regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.22552548
77negative regulation of B cell proliferation (GO:0030889)3.21322827
78response to host immune response (GO:0052572)3.21087724
79response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.21087724
80positive regulation of DNA recombination (GO:0045911)3.20285741
81myeloid dendritic cell differentiation (GO:0043011)3.19476297
82negative regulation of T cell mediated immunity (GO:0002710)3.19331609
83regulation of T cell receptor signaling pathway (GO:0050856)3.18734175
84production of molecular mediator involved in inflammatory response (GO:0002532)3.18397068
85cytidine deamination (GO:0009972)3.15246849
86cytidine metabolic process (GO:0046087)3.15246849
87cytidine catabolic process (GO:0006216)3.15246849
88antigen processing and presentation via MHC class Ib (GO:0002475)3.14345184
89leukocyte degranulation (GO:0043299)3.13735526
90macrophage activation (GO:0042116)3.12952471
91immunoglobulin mediated immune response (GO:0016064)3.12512806
92neutrophil mediated immunity (GO:0002446)3.11636981
93cellular response to type I interferon (GO:0071357)3.11385863
94type I interferon signaling pathway (GO:0060337)3.11385863
95positive regulation of natural killer cell mediated immunity (GO:0002717)3.11193332
96positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.11193332
97T cell proliferation (GO:0042098)3.08646380
98response to type I interferon (GO:0034340)3.08274060
99regulation of leukocyte mediated cytotoxicity (GO:0001910)3.06377315
100lymphocyte homeostasis (GO:0002260)3.03657893
101positive regulation of immunoglobulin production (GO:0002639)3.02877501
102alpha-beta T cell activation (GO:0046631)3.02572435
103negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.01732752
104pyrimidine ribonucleoside catabolic process (GO:0046133)3.01545700
105regulation of mast cell degranulation (GO:0043304)3.01371212
106positive regulation of mast cell activation (GO:0033005)3.00504571
107negative regulation of phagocytosis (GO:0050765)2.99523673
108positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.99383101
109positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.99274206
110negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.98569915
111regulation of cell killing (GO:0031341)2.97576175
112interferon-gamma-mediated signaling pathway (GO:0060333)2.97477615
113defense response to protozoan (GO:0042832)2.97117069
114response to protozoan (GO:0001562)2.96565244
115regulation of T cell mediated cytotoxicity (GO:0001914)2.96427771
116regulation of response to interferon-gamma (GO:0060330)2.95637121
117B cell mediated immunity (GO:0019724)2.95521697
118neutrophil activation involved in immune response (GO:0002283)2.95475855
119regulation of immunoglobulin production (GO:0002637)2.95469277
120T cell differentiation (GO:0030217)2.95389135
121regulation of mast cell activation (GO:0033003)2.95027830
122NIK/NF-kappaB signaling (GO:0038061)2.92719224
123myeloid leukocyte activation (GO:0002274)2.92572986
124negative regulation of adaptive immune response (GO:0002820)2.92562233
125regulation of B cell proliferation (GO:0030888)2.92295492
126regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.90904905
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.89217715
128regulation of chronic inflammatory response (GO:0002676)2.89185281
129alpha-beta T cell differentiation (GO:0046632)2.87889275
130cellular extravasation (GO:0045123)2.87832240
131negative regulation of lymphocyte mediated immunity (GO:0002707)2.87477002
132positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87073696
133respiratory burst (GO:0045730)2.86842336
134positive regulation of humoral immune response (GO:0002922)2.85779995
135positive regulation of cell killing (GO:0031343)2.85315608
136immune response-activating cell surface receptor signaling pathway (GO:0002429)2.85163739
137mature B cell differentiation (GO:0002335)2.84948908
138modulation by symbiont of host immune response (GO:0052553)2.83186752
139positive regulation by symbiont of host defense response (GO:0052509)2.83186752
140modulation by symbiont of host defense response (GO:0052031)2.83186752
141modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.83186752
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.83186752

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.52217389
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.36739866
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.40367928
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.80386347
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.72571263
6E2F7_22180533_ChIP-Seq_HELA_Human3.72479042
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.66103449
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.64310619
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.52932969
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.44191465
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.11530116
12MYC_22102868_ChIP-Seq_BL_Human3.10144589
13* RUNX_20019798_ChIP-Seq_JUKART_Human3.07607877
14* MYB_26560356_Chip-Seq_TH2_Human3.01220853
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.00186719
16* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.95890767
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89684385
18SCL_19346495_ChIP-Seq_HPC-7_Human2.87761542
19* IRF8_27001747_Chip-Seq_BMDM_Mouse2.83999619
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69303431
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69130062
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62612677
23* MAF_26560356_Chip-Seq_TH1_Human2.57116255
24VDR_21846776_ChIP-Seq_THP-1_Human2.50790742
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.49673123
26* MYB_26560356_Chip-Seq_TH1_Human2.43217077
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39808739
28SPI1_23547873_ChIP-Seq_NB4_Human2.32891202
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.32797458
30UTX_26944678_Chip-Seq_JUKART_Human2.28332529
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.12499662
32VDR_24763502_ChIP-Seq_THP-1_Human2.07213916
33BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06995164
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.02901052
35NOTCH1_21737748_ChIP-Seq_TLL_Human2.01048719
36TCF7_22412390_ChIP-Seq_EML_Mouse1.94571776
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90470140
38* GATA3_27048872_Chip-Seq_THYMUS_Human1.89132947
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84334806
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83049484
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81631281
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75712607
43SPI1_23127762_ChIP-Seq_K562_Human1.70411159
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63232990
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.61985926
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61220252
47* MAF_26560356_Chip-Seq_TH2_Human1.60740502
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58762852
49* PU_27001747_Chip-Seq_BMDM_Mouse1.54741303
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53160748
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51864029
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47677531
53* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44088160
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40471802
55GATA3_26560356_Chip-Seq_TH2_Human1.35286635
56KDM2B_26808549_Chip-Seq_DND41_Human1.31164160
57GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29820005
58* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28228204
59CIITA_25753668_ChIP-Seq_RAJI_Human1.25870639
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25111929
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24943135
62* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24363229
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24235454
64* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20204768
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19826113
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19242909
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17589032
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17264056
69* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13053352
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12976653
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12594657
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11458293
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09527810
74* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08569854
75* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08238644
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08071377
77VDR_23849224_ChIP-Seq_CD4+_Human1.05047875
78* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03928884
79* GATA1_19941827_ChIP-Seq_MEL_Mouse1.01085085
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99883685
81GATA2_21666600_ChIP-Seq_HMVEC_Human0.97231953
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97135280
83VDR_24787735_ChIP-Seq_THP-1_Human0.96891416
84STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96619926
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95871106
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.92409354
87* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91239695
88* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91071659
89FOXP3_21729870_ChIP-Seq_TREG_Human0.90092914
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89818463
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87998743
92* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86707420
93* SMRT_27268052_Chip-Seq_Bcells_Human0.85608018
94BCL6_27268052_Chip-Seq_Bcells_Human0.82626275
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.81312946
96* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80359851
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78700064
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.77508671
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77324177
100GATA2_19941826_ChIP-Seq_K562_Human0.76637999
101* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75933602
102* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73329384
103NCOR1_26117541_ChIP-Seq_K562_Human0.72949242
104* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72521220
105GATA3_26560356_Chip-Seq_TH1_Human0.72465857
106GATA1_22025678_ChIP-Seq_K562_Human0.71885242
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71629774
108GATA1_19941826_ChIP-Seq_K562_Human0.71460204
109FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.70857991
110* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69988315
111ELK1_19687146_ChIP-ChIP_HELA_Human0.69419588
112SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.68787627
113* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68478387
114BCOR_27268052_Chip-Seq_Bcells_Human0.67994658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.33134403
2MP0005671_abnormal_response_to4.19743415
3MP0003763_abnormal_thymus_physiology3.66274782
4MP0001800_abnormal_humoral_immune3.20833254
5MP0000685_abnormal_immune_system3.20781167
6MP0003303_peritoneal_inflammation3.15296295
7MP0009785_altered_susceptibility_to3.11480816
8MP0001790_abnormal_immune_system3.08144613
9MP0005387_immune_system_phenotype3.08144613
10MP0005000_abnormal_immune_tolerance3.04026329
11MP0003436_decreased_susceptibility_to3.02324319
12MP0002723_abnormal_immune_serum2.78860164
13MP0002452_abnormal_antigen_presenting2.77776756
14MP0002420_abnormal_adaptive_immunity2.76957996
15MP0001819_abnormal_immune_cell2.74266604
16MP0005025_abnormal_response_to2.65691558
17MP0002166_altered_tumor_susceptibility2.65521609
18MP0003300_gastrointestinal_ulcer2.64519198
19* MP0002398_abnormal_bone_marrow2.55310673
20MP0002419_abnormal_innate_immunity2.51038031
21MP0002405_respiratory_system_inflammati2.49974197
22MP0002148_abnormal_hypersensitivity_rea2.48201310
23MP0006082_CNS_inflammation2.35950365
24MP0009333_abnormal_splenocyte_physiolog2.33362158
25MP0003724_increased_susceptibility_to2.33079529
26MP0002396_abnormal_hematopoietic_system2.32376370
27* MP0000716_abnormal_immune_system2.29679830
28MP0001873_stomach_inflammation2.24392150
29MP0002006_tumorigenesis2.21043693
30MP0010155_abnormal_intestine_physiology2.15145929
31MP0005464_abnormal_platelet_physiology2.14573277
32MP0001853_heart_inflammation2.14367269
33MP0000689_abnormal_spleen_morphology2.11679012
34MP0002722_abnormal_immune_system2.11040298
35MP0000703_abnormal_thymus_morphology2.08755695
36MP0000465_gastrointestinal_hemorrhage2.01387009
37MP0004947_skin_inflammation1.92383374
38* MP0002429_abnormal_blood_cell1.90403135
39MP0001845_abnormal_inflammatory_respons1.86976552
40MP0004510_myositis1.85852178
41MP0004808_abnormal_hematopoietic_stem1.77795967
42MP0003866_abnormal_defecation1.72620856
43MP0002933_joint_inflammation1.63836611
44MP0008260_abnormal_autophagy1.52434559
45MP0004381_abnormal_hair_follicle1.49655620
46MP0001533_abnormal_skeleton_physiology1.46868183
47MP0001545_abnormal_hematopoietic_system1.43117144
48MP0005397_hematopoietic_system_phenotyp1.43117144
49MP0000858_altered_metastatic_potential1.35049345
50MP0000490_abnormal_crypts_of1.31527189
51MP0008469_abnormal_protein_level1.26213271
52MP0009278_abnormal_bone_marrow1.23016359
53MP0005310_abnormal_salivary_gland1.21986923
54MP0003448_altered_tumor_morphology1.21508631
55MP0005174_abnormal_tail_pigmentation1.11551680
56MP0001851_eye_inflammation1.06442314
57MP0002132_abnormal_respiratory_system1.05962097
58MP0002998_abnormal_bone_remodeling1.02384134
59MP0008057_abnormal_DNA_replication1.02208804
60MP0004883_abnormal_blood_vessel0.98882303
61MP0003656_abnormal_erythrocyte_physiolo0.98508864
62MP0000343_altered_response_to0.98343287
63MP0003172_abnormal_lysosome_physiology0.98328130
64MP0003183_abnormal_peptide_metabolism0.98101553
65MP0003191_abnormal_cellular_cholesterol0.96474165
66MP0002019_abnormal_tumor_incidence0.94057200
67MP0009764_decreased_sensitivity_to0.91744809
68MP0005451_abnormal_body_composition0.90733670
69MP0005058_abnormal_lysosome_morphology0.87994032
70MP0005075_abnormal_melanosome_morpholog0.85388388
71MP0003690_abnormal_glial_cell0.83015681
72MP0003075_altered_response_to0.82190856
73MP0005076_abnormal_cell_differentiation0.82116930
74MP0005164_abnormal_response_to0.80036852
75MP0005166_decreased_susceptibility_to0.78792161
76MP0001663_abnormal_digestive_system0.77970030
77MP0010307_abnormal_tumor_latency0.77183659
78MP0010352_gastrointestinal_tract_polyps0.73920638
79MP0010094_abnormal_chromosome_stability0.71296741
80MP0001986_abnormal_taste_sensitivity0.71048136
81MP0009763_increased_sensitivity_to0.70909462
82MP0003693_abnormal_embryo_hatching0.70119530
83MP0000249_abnormal_blood_vessel0.69682914
84MP0000015_abnormal_ear_pigmentation0.69588277
85MP0004782_abnormal_surfactant_physiolog0.69196789
86MP0008007_abnormal_cellular_replicative0.69074180
87MP0008961_abnormal_basal_metabolism0.68140653
88MP0003795_abnormal_bone_structure0.67268990
89MP0002095_abnormal_skin_pigmentation0.66992338
90MP0002009_preneoplasia0.66884383
91MP0000604_amyloidosis0.65019087
92MP0003077_abnormal_cell_cycle0.64264136
93MP0008004_abnormal_stomach_pH0.60791608
94MP0000920_abnormal_myelination0.59451822
95MP0006054_spinal_hemorrhage0.59415107
96MP0005390_skeleton_phenotype0.55718833
97MP0008874_decreased_physiological_sensi0.55418754
98MP0003806_abnormal_nucleotide_metabolis0.55334754
99MP0004130_abnormal_muscle_cell0.53457794
100MP0008873_increased_physiological_sensi0.53247881
101MP0000569_abnormal_digit_pigmentation0.53004746
102MP0005023_abnormal_wound_healing0.52652628
103MP0002136_abnormal_kidney_physiology0.52565961
104MP0003828_pulmonary_edema0.52377058
105MP0000477_abnormal_intestine_morphology0.51757510
106MP0000609_abnormal_liver_physiology0.50550368
107MP0002277_abnormal_respiratory_mucosa0.50220993
108MP0000313_abnormal_cell_death0.49581790
109MP0002693_abnormal_pancreas_physiology0.49321574
110MP0008058_abnormal_DNA_repair0.48947438
111MP0003045_fibrosis0.48122054
112MP0009840_abnormal_foam_cell0.46616186
113MP0009765_abnormal_xenobiotic_induced0.46614346
114MP0002138_abnormal_hepatobiliary_system0.46442324
115MP0005319_abnormal_enzyme/_coenzyme0.44445187
116MP0003787_abnormal_imprinting0.42811773
117MP0005388_respiratory_system_phenotype0.42324055
118MP0002133_abnormal_respiratory_system0.42324055
119MP0001191_abnormal_skin_condition0.41194770

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.34028410
2Myositis (HP:0100614)5.28846367
3Abnormality of T cell number (HP:0011839)5.11249041
4Eczematoid dermatitis (HP:0000976)5.04327056
5Optic neuritis (HP:0100653)4.85540843
6Retrobulbar optic neuritis (HP:0100654)4.85540843
7IgM deficiency (HP:0002850)4.79749283
8Recurrent abscess formation (HP:0002722)4.77164520
9Elevated erythrocyte sedimentation rate (HP:0003565)4.69530288
10Orchitis (HP:0100796)4.61506081
11Recurrent viral infections (HP:0004429)4.57541748
12B lymphocytopenia (HP:0010976)4.52430260
13Abnormality of B cell number (HP:0010975)4.52430260
14Recurrent fungal infections (HP:0002841)4.48883601
15Recurrent bacterial skin infections (HP:0005406)4.24906365
16Panhypogammaglobulinemia (HP:0003139)4.24089743
17Abnormality of T cells (HP:0002843)4.19313710
18Severe combined immunodeficiency (HP:0004430)4.13500533
19Stomatitis (HP:0010280)4.03044402
20Meningitis (HP:0001287)3.92284105
21Thyroiditis (HP:0100646)3.89215203
22Combined immunodeficiency (HP:0005387)3.87627709
23Recurrent bronchitis (HP:0002837)3.86635413
24Chronic obstructive pulmonary disease (HP:0006510)3.63741556
25Obstructive lung disease (HP:0006536)3.63741556
26Vasculitis (HP:0002633)3.62601511
27Pulmonary infiltrates (HP:0002113)3.53057479
28Mediastinal lymphadenopathy (HP:0100721)3.52767597
29IgG deficiency (HP:0004315)3.49005253
30Keratoconjunctivitis sicca (HP:0001097)3.39888075
31Arterial thrombosis (HP:0004420)3.32314946
32Chronic mucocutaneous candidiasis (HP:0002728)3.28524820
33Recurrent cutaneous fungal infections (HP:0011370)3.28524820
34Chronic otitis media (HP:0000389)3.27477381
35Eosinophilia (HP:0001880)3.24949354
36Recurrent skin infections (HP:0001581)3.19236978
37Leukocytosis (HP:0001974)3.16104261
38Hemoptysis (HP:0002105)3.14417434
39Abnormality of eosinophils (HP:0001879)3.14393343
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.14356210
41Abnormality of T cell physiology (HP:0011840)3.11151249
42Recurrent gram-negative bacterial infections (HP:0005420)3.06650238
43Keratoconjunctivitis (HP:0001096)3.06495114
44Lymphopenia (HP:0001888)3.05025389
45Thrombocytosis (HP:0001894)3.04734222
46Nasal polyposis (HP:0100582)2.96724910
47Urticaria (HP:0001025)2.93556965
48Abnormality of cells of the lymphoid lineage (HP:0012140)2.92937205
49Agammaglobulinemia (HP:0004432)2.92865149
50Inflammation of the large intestine (HP:0002037)2.89417155
51Encephalitis (HP:0002383)2.88106401
52Pustule (HP:0200039)2.85411647
53Granulocytopenia (HP:0001913)2.85143490
54Cellulitis (HP:0100658)2.83644680
55Chronic diarrhea (HP:0002028)2.80972696
56Spontaneous hematomas (HP:0007420)2.80147381
57Gastrointestinal inflammation (HP:0004386)2.78394896
58Abnormality of the prostate (HP:0008775)2.75711697
59Petechiae (HP:0000967)2.72106269
60Chest pain (HP:0100749)2.71579777
61Abnormality of the fingertips (HP:0001211)2.71010998
62Autoimmune thrombocytopenia (HP:0001973)2.70509712
63Abnormality of macrophages (HP:0004311)2.69595981
64Hypoplasia of the thymus (HP:0000778)2.68069910
65Gastrointestinal stroma tumor (HP:0100723)2.68020158
66IgA deficiency (HP:0002720)2.67126718
67Recurrent sinusitis (HP:0011108)2.63444519
68Epistaxis (HP:0000421)2.61155329
69Hypochromic anemia (HP:0001931)2.60563537
70Pulmonary embolism (HP:0002204)2.59310518
71Hypochromic microcytic anemia (HP:0004840)2.59231560
72Colitis (HP:0002583)2.59205808
73Abnormality of the nasal mucosa (HP:0000433)2.59197225
74Gastrointestinal infarctions (HP:0005244)2.54455560
75Increased density of long bones (HP:0006392)2.52037455
76Gingivitis (HP:0000230)2.49113683
77Lymphoma (HP:0002665)2.46928576
78Prolonged bleeding time (HP:0003010)2.45191449
79Episodic fever (HP:0001954)2.44799105
80Periodontitis (HP:0000704)2.42566358
81Abnormality of glycolipid metabolism (HP:0010969)2.41543849
82Abnormality of liposaccharide metabolism (HP:0010968)2.41543849
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.41543849
84Gangrene (HP:0100758)2.41414280
85Gingival bleeding (HP:0000225)2.34999653
86Increased cerebral lipofuscin (HP:0011813)2.32402315
87Osteomyelitis (HP:0002754)2.26940718
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25786745
89Abnormality of the pleura (HP:0002103)2.23534471
90Interstitial pulmonary disease (HP:0006530)2.21807754
91Verrucae (HP:0200043)2.21581402
92Papilloma (HP:0012740)2.21581402
93Premature loss of primary teeth (HP:0006323)2.20674140
94Joint swelling (HP:0001386)2.19031941
95Increased IgM level (HP:0003496)2.15377156
96Autoimmune hemolytic anemia (HP:0001890)2.12913114
97Bronchitis (HP:0012387)2.07197853
98Abnormal platelet volume (HP:0011876)2.07190845
99Increased neuronal autofluorescent lipopigment (HP:0002074)2.06617155
100Vertigo (HP:0002321)2.05530559
101Glomerulopathy (HP:0100820)2.05240349
102Restrictive lung disease (HP:0002091)2.05044250
103Hypergammaglobulinemia (HP:0010702)2.05005007
104Purpura (HP:0000979)2.04503445
105Increased IgE level (HP:0003212)2.03884564
106Abnormal platelet function (HP:0011869)2.02195294
107Impaired platelet aggregation (HP:0003540)2.02195294
108Keratitis (HP:0000491)2.01759069
109Abnormality of the pericardium (HP:0001697)1.99511694
110Sepsis (HP:0100806)1.98814294
111Fatigue (HP:0012378)1.98497852
112Polyneuropathy (HP:0001271)1.98223789
113Recurrent pneumonia (HP:0006532)1.97021463
114Arthralgia (HP:0002829)1.96850685
115Stomach cancer (HP:0012126)1.94689789
116Hepatosplenomegaly (HP:0001433)1.94507240
117Abnormality of the endocardium (HP:0004306)1.92835946
118Anorexia (HP:0002039)1.92779009
119Acute hepatic failure (HP:0006554)1.92051240
120Skin rash (HP:0000988)1.90836882
121Slow saccadic eye movements (HP:0000514)1.89959451

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.59907621
2MAP4K15.68540983
3ZAP702.98050552
4ITK2.72795849
5JAK32.62259804
6MAP3K142.51347805
7TYK22.32699936
8STK102.20288185
9TEC2.18142312
10BTK2.07506240
11BLK2.06845224
12IRAK42.06449403
13IKBKE2.04854863
14SYK2.01884893
15JAK11.92949866
16TBK11.88195542
17GRK61.83613362
18KIT1.82889719
19TAOK31.72769930
20CSK1.72221319
21LCK1.68558970
22HCK1.66775867
23FGR1.58598406
24RIPK41.56695781
25PRPF4B1.54121913
26IRAK31.53741347
27IKBKB1.50267054
28CSF1R1.43612064
29FGFR41.42492583
30FGFR31.41300512
31TGFBR21.40079700
32EEF2K1.35712629
33FES1.34311480
34MAP3K131.28724717
35CLK11.25398003
36IRAK11.24819051
37PIM11.24392249
38LYN1.17933784
39CAMKK21.15159239
40MAP2K31.12795812
41MAP3K31.06751563
42IRAK21.06489816
43CHUK1.00404586
44JAK21.00230292
45PIK3CG0.97476378
46ERN10.95685068
47LRRK20.95387487
48SIK20.93296891
49BMPR20.92134068
50RPS6KA40.90655047
51PRKCQ0.90144788
52EPHB10.87609806
53MAP3K100.87034847
54GRK70.84793840
55MAP3K10.84429789
56PKN20.83264064
57MARK30.79575867
58NLK0.76294682
59MST40.74290429
60MAP3K60.73095687
61FLT30.68473730
62TESK20.67011651
63TSSK60.65604596
64PDK10.64058301
65NME20.58504123
66TNK20.58436916
67MAP3K120.57733287
68KDR0.57599465
69ACVR1B0.57419170
70STK40.57220385
71CDK40.56674623
72TAOK20.56207631
73MAP3K70.55593695
74BCKDK0.55496175
75KSR20.55060888
76SIK30.54847966
77TRIB30.54577249
78MARK20.53870752
79CDC42BPA0.51396030
80CDK60.51104692
81CDK120.50122499
82PRKCH0.49600326
83MAPK40.49163376
84MAP3K50.47841345
85PDGFRB0.47560796
86CAMKK10.46445705
87TAOK10.46342454
88MAP2K20.44319818
89NEK90.44168090
90PDPK10.42843209
91FYN0.42474312
92ALK0.42432927
93MATK0.42358242
94STK240.42171020
95PRKD20.40355216
96STK110.40333700
97PTK2B0.39742479
98DAPK20.38391496
99MAPK120.38026895
100TYRO30.37798302
101MAPK70.37065317
102SGK30.36391139
103SGK20.35263419
104HIPK20.34737736
105MAPKAPK20.34655936
106MAP3K80.34463361
107ABL10.33443177
108EPHA30.32048946
109MAP3K20.32014091
110EGFR0.31969736
111MAP2K60.31851396
112RPS6KA60.31629817
113CDK90.31560063
114CAMK40.31556161
115MAP3K110.30931110
116MELK0.30477791
117IGF1R0.30420377
118CDK190.29851516
119PIM20.29742261
120RET0.29303644
121MAPK110.27610725
122FRK0.26092718
123NEK20.26049053
124TGFBR10.25849025
125ADRBK20.25310419
126YES10.25255085
127PTK60.24239256
128INSR0.24038140
129MAPK30.22892128
130RAF10.22111322
131PRKCD0.21883019
132RPS6KC10.20577719
133RPS6KL10.20577719
134TRPM70.19818496
135DMPK0.19727581

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.22725309
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.23281148
3T cell receptor signaling pathway_Homo sapiens_hsa046602.99240232
4Allograft rejection_Homo sapiens_hsa053302.84973596
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.79101974
6Leishmaniasis_Homo sapiens_hsa051402.75346712
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.56663130
8Graft-versus-host disease_Homo sapiens_hsa053322.51025686
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.50536486
10Hematopoietic cell lineage_Homo sapiens_hsa046402.43063552
11Antigen processing and presentation_Homo sapiens_hsa046122.39809363
12Measles_Homo sapiens_hsa051622.35763889
13Osteoclast differentiation_Homo sapiens_hsa043802.34794579
14Asthma_Homo sapiens_hsa053102.31954676
15B cell receptor signaling pathway_Homo sapiens_hsa046622.29452728
16Autoimmune thyroid disease_Homo sapiens_hsa053201.92971618
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.77031399
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.70983239
19Staphylococcus aureus infection_Homo sapiens_hsa051501.69992529
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57949612
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56748915
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55973244
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54426235
24Herpes simplex infection_Homo sapiens_hsa051681.53298316
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52995727
26Legionellosis_Homo sapiens_hsa051341.50673688
27Chemokine signaling pathway_Homo sapiens_hsa040621.48427238
28Toxoplasmosis_Homo sapiens_hsa051451.48080691
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44513935
30Pertussis_Homo sapiens_hsa051331.36639530
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35675383
32Tuberculosis_Homo sapiens_hsa051521.32885305
33TNF signaling pathway_Homo sapiens_hsa046681.29292206
34Type I diabetes mellitus_Homo sapiens_hsa049401.26950647
35Viral myocarditis_Homo sapiens_hsa054161.26531675
36Hepatitis B_Homo sapiens_hsa051611.25680733
37Malaria_Homo sapiens_hsa051441.24335352
38Influenza A_Homo sapiens_hsa051641.22209484
39Shigellosis_Homo sapiens_hsa051311.21715521
40Acute myeloid leukemia_Homo sapiens_hsa052211.19599842
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.19458730
42Apoptosis_Homo sapiens_hsa042101.15690771
43Platelet activation_Homo sapiens_hsa046111.06039899
44Salmonella infection_Homo sapiens_hsa051321.05737303
45Chronic myeloid leukemia_Homo sapiens_hsa052201.03476174
46Pancreatic cancer_Homo sapiens_hsa052120.94526563
47Rheumatoid arthritis_Homo sapiens_hsa053230.93659080
48Epstein-Barr virus infection_Homo sapiens_hsa051690.91691096
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90804916
50HTLV-I infection_Homo sapiens_hsa051660.84104890
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84103501
52Non-homologous end-joining_Homo sapiens_hsa034500.83428741
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.81883856
54Other glycan degradation_Homo sapiens_hsa005110.81881109
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81374384
56African trypanosomiasis_Homo sapiens_hsa051430.77532510
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71383343
58Viral carcinogenesis_Homo sapiens_hsa052030.70914253
59Prolactin signaling pathway_Homo sapiens_hsa049170.70221762
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69279590
61Hepatitis C_Homo sapiens_hsa051600.68775420
62DNA replication_Homo sapiens_hsa030300.68395574
63Colorectal cancer_Homo sapiens_hsa052100.64913775
64Dorso-ventral axis formation_Homo sapiens_hsa043200.60773148
65Non-small cell lung cancer_Homo sapiens_hsa052230.59630644
66VEGF signaling pathway_Homo sapiens_hsa043700.58776793
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57502814
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56708618
69Base excision repair_Homo sapiens_hsa034100.54595444
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53527488
71Lysosome_Homo sapiens_hsa041420.51991528
72Ribosome_Homo sapiens_hsa030100.47959776
73Regulation of autophagy_Homo sapiens_hsa041400.47408384
74Small cell lung cancer_Homo sapiens_hsa052220.46819990
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46008867
76Spliceosome_Homo sapiens_hsa030400.45609417
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45586013
78p53 signaling pathway_Homo sapiens_hsa041150.45257033
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.45190301
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.43852687
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43582443
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.42407867
83FoxO signaling pathway_Homo sapiens_hsa040680.41514960
84Endocytosis_Homo sapiens_hsa041440.40325447
85Mismatch repair_Homo sapiens_hsa034300.39880492
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38131221
87Phagosome_Homo sapiens_hsa041450.36789486
88MAPK signaling pathway_Homo sapiens_hsa040100.36703735
89Choline metabolism in cancer_Homo sapiens_hsa052310.34114184
90HIF-1 signaling pathway_Homo sapiens_hsa040660.32845490
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32794752
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31135757
93Amoebiasis_Homo sapiens_hsa051460.30219633
94Notch signaling pathway_Homo sapiens_hsa043300.29834236
95mTOR signaling pathway_Homo sapiens_hsa041500.29765317
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29425216
97RNA degradation_Homo sapiens_hsa030180.28328228
98Systemic lupus erythematosus_Homo sapiens_hsa053220.27526298
99Renal cell carcinoma_Homo sapiens_hsa052110.27405522
100GnRH signaling pathway_Homo sapiens_hsa049120.26251594
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25626199
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.25424362
103Insulin resistance_Homo sapiens_hsa049310.25361758
104Type II diabetes mellitus_Homo sapiens_hsa049300.24858916
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24128567
106MicroRNAs in cancer_Homo sapiens_hsa052060.23872544
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.23402930
108Thyroid cancer_Homo sapiens_hsa052160.22675283
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21358165
110Endometrial cancer_Homo sapiens_hsa052130.21295049
111Inositol phosphate metabolism_Homo sapiens_hsa005620.18431310
112Ras signaling pathway_Homo sapiens_hsa040140.18425037
113Prostate cancer_Homo sapiens_hsa052150.18254059
114Rap1 signaling pathway_Homo sapiens_hsa040150.17986962
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16702614
116Pathways in cancer_Homo sapiens_hsa052000.15399905
117Cell cycle_Homo sapiens_hsa041100.15378442

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