SKP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.27534466
2DNA unwinding involved in DNA replication (GO:0006268)5.24027960
3nuclear pore organization (GO:0006999)4.98573575
4nuclear pore complex assembly (GO:0051292)4.90081744
5mitotic metaphase plate congression (GO:0007080)4.80806336
6DNA replication initiation (GO:0006270)4.61889880
7protein localization to chromosome, centromeric region (GO:0071459)4.61247799
8DNA strand elongation involved in DNA replication (GO:0006271)4.52713801
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.49129365
10DNA replication checkpoint (GO:0000076)4.43512191
11kinetochore organization (GO:0051383)4.32412889
12DNA strand elongation (GO:0022616)4.30897605
13DNA replication-dependent nucleosome organization (GO:0034723)4.28712237
14DNA replication-dependent nucleosome assembly (GO:0006335)4.28712237
15mitotic sister chromatid segregation (GO:0000070)4.22933375
16metaphase plate congression (GO:0051310)4.21173182
17mitotic chromosome condensation (GO:0007076)4.19285004
18sister chromatid segregation (GO:0000819)4.18512569
19mitotic nuclear envelope disassembly (GO:0007077)4.17559070
20mitotic sister chromatid cohesion (GO:0007064)4.14844497
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.10368632
22regulation of spindle organization (GO:0090224)4.00527108
23telomere maintenance via semi-conservative replication (GO:0032201)3.98477857
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.94165879
25nucleobase biosynthetic process (GO:0046112)3.90507571
26CENP-A containing nucleosome assembly (GO:0034080)3.87819157
27nuclear envelope disassembly (GO:0051081)3.87283731
28membrane disassembly (GO:0030397)3.87283731
29chromatin remodeling at centromere (GO:0031055)3.86491797
30DNA replication-independent nucleosome assembly (GO:0006336)3.77510041
31DNA replication-independent nucleosome organization (GO:0034724)3.77510041
32kinetochore assembly (GO:0051382)3.77416406
33purine nucleobase biosynthetic process (GO:0009113)3.77037865
34pore complex assembly (GO:0046931)3.76926453
35mitotic recombination (GO:0006312)3.74775972
36attachment of spindle microtubules to kinetochore (GO:0008608)3.68642055
37establishment of chromosome localization (GO:0051303)3.68451025
38telomere maintenance via recombination (GO:0000722)3.67278354
39spindle checkpoint (GO:0031577)3.66398872
40regulation of chromosome segregation (GO:0051983)3.61864371
41histone exchange (GO:0043486)3.61209404
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.59850671
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.59850671
44negative regulation of chromosome segregation (GO:0051985)3.58504014
45IMP biosynthetic process (GO:0006188)3.54838469
46regulation of centrosome cycle (GO:0046605)3.53436580
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.52879119
48negative regulation of sister chromatid segregation (GO:0033046)3.52879119
49negative regulation of mitotic sister chromatid separation (GO:2000816)3.52879119
50negative regulation of mitotic sister chromatid segregation (GO:0033048)3.52879119
51protein localization to chromosome (GO:0034502)3.52070124
52spindle assembly checkpoint (GO:0071173)3.50230683
53regulation of sister chromatid cohesion (GO:0007063)3.48771872
54regulation of mitotic metaphase/anaphase transition (GO:0030071)3.48267132
55DNA ligation (GO:0006266)3.44703363
56positive regulation of chromosome segregation (GO:0051984)3.44682092
57regulation of mitotic spindle organization (GO:0060236)3.43781900
58mitotic spindle checkpoint (GO:0071174)3.43323744
59mitotic spindle assembly checkpoint (GO:0007094)3.43182794
60negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.42913561
61chromosome condensation (GO:0030261)3.42165384
62DNA geometric change (GO:0032392)3.41969002
63formation of translation preinitiation complex (GO:0001731)3.41107419
64DNA duplex unwinding (GO:0032508)3.40780183
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.40671292
66pre-miRNA processing (GO:0031054)3.40270729
67establishment of integrated proviral latency (GO:0075713)3.38327292
68regulation of centriole replication (GO:0046599)3.37437787
69replication fork processing (GO:0031297)3.33967517
70chromatin assembly or disassembly (GO:0006333)3.33813416
71nucleotide-excision repair, DNA gap filling (GO:0006297)3.31626785
72ATP-dependent chromatin remodeling (GO:0043044)3.30481251
73telomere maintenance via telomere lengthening (GO:0010833)3.29733865
74postreplication repair (GO:0006301)3.29200246
75regulation of sister chromatid segregation (GO:0033045)3.29148483
76regulation of mitotic sister chromatid separation (GO:0010965)3.29148483
77regulation of mitotic sister chromatid segregation (GO:0033047)3.29148483
78meiotic chromosome segregation (GO:0045132)3.24993507
79regulation of RNA export from nucleus (GO:0046831)3.24942126
80chromosome segregation (GO:0007059)3.24262205
81double-strand break repair via nonhomologous end joining (GO:0006303)3.24106239
82non-recombinational repair (GO:0000726)3.24106239
83DNA packaging (GO:0006323)3.18287847
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17531855
85DNA conformation change (GO:0071103)3.16991538
86synapsis (GO:0007129)3.16327070
87paraxial mesoderm development (GO:0048339)3.15150181
88ribosome assembly (GO:0042255)3.12287582
89heterochromatin organization (GO:0070828)3.11693477
90regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.09271734
91regulation of mitotic spindle checkpoint (GO:1903504)3.09271734
92mitotic G2/M transition checkpoint (GO:0044818)3.09147632
93DNA topological change (GO:0006265)3.09047179
94regulation of DNA methylation (GO:0044030)3.09003613
95folic acid-containing compound biosynthetic process (GO:0009396)3.06530428
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02828885
97regulation of DNA endoreduplication (GO:0032875)3.02488936
98nuclear envelope organization (GO:0006998)3.01754961
99IMP metabolic process (GO:0046040)2.99971020
100microtubule depolymerization (GO:0007019)2.99768315
101positive regulation of mitotic sister chromatid separation (GO:1901970)2.99166798
102positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.99166798
103positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.99166798
104negative regulation of DNA-dependent DNA replication (GO:2000104)2.96203458
105translesion synthesis (GO:0019985)2.94465988
106DNA strand renaturation (GO:0000733)2.93946191
107protein K6-linked ubiquitination (GO:0085020)2.92959239
108base-excision repair (GO:0006284)2.92886578
109DNA double-strand break processing (GO:0000729)2.90714837
110regulation of double-strand break repair via homologous recombination (GO:0010569)2.89734041
111regulation of centrosome duplication (GO:0010824)2.89125606
112regulation of double-strand break repair (GO:2000779)2.88966881
113positive regulation of histone H3-K4 methylation (GO:0051571)2.88572947
114negative regulation of RNA splicing (GO:0033119)2.88543041
115regulation of nuclear cell cycle DNA replication (GO:0033262)2.88516312
116proteasome assembly (GO:0043248)2.88194659
117mismatch repair (GO:0006298)2.87412874
118telomere maintenance (GO:0000723)2.86486879
119telomere organization (GO:0032200)2.85658502
120histone-serine phosphorylation (GO:0035404)2.85375894
121* mitotic cell cycle (GO:0000278)2.84187811
122mRNA splicing, via spliceosome (GO:0000398)2.83566442
123RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83566442
124L-serine metabolic process (GO:0006563)2.83536927
125RNA splicing, via transesterification reactions (GO:0000375)2.83535734
126ribosome biogenesis (GO:0042254)2.83175124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.00578008
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.68087037
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.04143448
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.91440189
5* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.99551374
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99309606
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97206221
8* AR_21909140_ChIP-Seq_LNCAP_Human2.85281961
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74780161
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.60221407
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48040418
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47642815
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.45719483
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37119507
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.32673992
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.30917582
17XRN2_22483619_ChIP-Seq_HELA_Human2.19959745
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18784261
19* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17644444
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16053707
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.12201244
22* ETS1_20019798_ChIP-Seq_JURKAT_Human2.05428304
23* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02841897
24MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02678424
25E2F7_22180533_ChIP-Seq_HELA_Human11.1626228
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97576033
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.92910787
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.87810888
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84661472
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79367221
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77451612
32TTF2_22483619_ChIP-Seq_HELA_Human1.75206036
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71099725
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71005702
35VDR_23849224_ChIP-Seq_CD4+_Human1.69044000
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65377032
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64279854
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61246918
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61204735
40DCP1A_22483619_ChIP-Seq_HELA_Human1.57317504
41FOXP3_21729870_ChIP-Seq_TREG_Human1.56265219
42GABP_19822575_ChIP-Seq_HepG2_Human1.54333319
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52090882
44CIITA_25753668_ChIP-Seq_RAJI_Human1.50503996
45MYC_22102868_ChIP-Seq_BL_Human1.49056166
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47493759
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46866123
48EWS_26573619_Chip-Seq_HEK293_Human1.44928712
49ELK1_19687146_ChIP-ChIP_HELA_Human1.43693661
50* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39761541
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38981444
52KDM5A_27292631_Chip-Seq_BREAST_Human1.38728082
53FUS_26573619_Chip-Seq_HEK293_Human1.37718735
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34907327
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33477525
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32432241
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25187599
58CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23637168
59NANOG_21062744_ChIP-ChIP_HESCs_Human1.21211528
60* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19724706
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19348352
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18451512
63* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17011222
64IRF1_19129219_ChIP-ChIP_H3396_Human1.16858387
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15860268
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15648600
67* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15553650
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.15037844
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.12876638
70* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12551152
71* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09292018
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08639323
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05992160
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05294307
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.04670396
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04553472
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03806574
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03679916
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03670611
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02087364
81ZNF274_21170338_ChIP-Seq_K562_Hela1.02003771
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01819313
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00396981
84MYC_18940864_ChIP-ChIP_HL60_Human0.99438401
85* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99336512
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97844836
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96745998
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95774999
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90334691
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89538483
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.86591818
92* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86070853
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85125268
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84178703
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84111524
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84111524
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84111524
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84006315
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.83862778
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83791190
101TFEB_21752829_ChIP-Seq_HELA_Human0.82454695
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82393346
103ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80869032
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80835431
105POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80113377
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79120221
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.76926668
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.76826409
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76259855
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76127507
111EZH2_22144423_ChIP-Seq_EOC_Human0.75643345
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.75542465
113CHD1_26751641_Chip-Seq_LNCaP_Human0.75179855
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72327054
115GATA1_26923725_Chip-Seq_HPCs_Mouse0.70510449
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.63295369
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.62403627
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.60754107
119IGF1R_20145208_ChIP-Seq_DFB_Human0.59841838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.26279660
2MP0010094_abnormal_chromosome_stability4.20326900
3MP0003111_abnormal_nucleus_morphology4.00658437
4MP0008057_abnormal_DNA_replication3.75957441
5MP0004957_abnormal_blastocyst_morpholog3.62185250
6MP0003077_abnormal_cell_cycle3.49733115
7MP0003123_paternal_imprinting3.44315967
8MP0009697_abnormal_copulation2.67035051
9MP0008058_abnormal_DNA_repair2.66106362
10MP0010030_abnormal_orbit_morphology2.49923352
11MP0003121_genomic_imprinting2.48006331
12MP0008932_abnormal_embryonic_tissue2.42191203
13MP0008007_abnormal_cellular_replicative2.39973456
14MP0001730_embryonic_growth_arrest2.26847294
15* MP0000350_abnormal_cell_proliferation2.07684261
16MP0008877_abnormal_DNA_methylation2.04051075
17MP0001672_abnormal_embryogenesis/_devel1.95273965
18MP0005380_embryogenesis_phenotype1.95273965
19MP0010352_gastrointestinal_tract_polyps1.94468012
20MP0009053_abnormal_anal_canal1.88516565
21MP0002085_abnormal_embryonic_tissue1.84765186
22MP0001697_abnormal_embryo_size1.83058192
23MP0004197_abnormal_fetal_growth/weight/1.79937831
24MP0002084_abnormal_developmental_patter1.77984410
25MP0010307_abnormal_tumor_latency1.74705446
26MP0003937_abnormal_limbs/digits/tail_de1.74690884
27MP0003984_embryonic_growth_retardation1.74174437
28MP0000537_abnormal_urethra_morphology1.73872960
29MP0002088_abnormal_embryonic_growth/wei1.71519162
30MP0001293_anophthalmia1.71041092
31MP0003567_abnormal_fetal_cardiomyocyte1.69573851
32MP0003122_maternal_imprinting1.68269320
33MP0002234_abnormal_pharynx_morphology1.68240916
34MP0002396_abnormal_hematopoietic_system1.58094056
35MP0005076_abnormal_cell_differentiation1.57453929
36MP0003890_abnormal_embryonic-extraembry1.56766575
37MP0002086_abnormal_extraembryonic_tissu1.55743318
38MP0002080_prenatal_lethality1.55101681
39MP0003119_abnormal_digestive_system1.49506199
40MP0005499_abnormal_olfactory_system1.41196849
41MP0005394_taste/olfaction_phenotype1.41196849
42MP0003385_abnormal_body_wall1.40945463
43MP0003705_abnormal_hypodermis_morpholog1.38338224
44MP0002938_white_spotting1.33143823
45MP0000428_abnormal_craniofacial_morphol1.31177506
46MP0003315_abnormal_perineum_morphology1.26598658
47MP0003786_premature_aging1.24484550
48MP0009672_abnormal_birth_weight1.22969835
49MP0003935_abnormal_craniofacial_develop1.22806231
50MP0003755_abnormal_palate_morphology1.22136139
51MP0004808_abnormal_hematopoietic_stem1.21344783
52MP0000049_abnormal_middle_ear1.20742297
53MP0002210_abnormal_sex_determination1.20450979
54MP0003115_abnormal_respiratory_system1.19264867
55MP0009703_decreased_birth_body1.18385586
56MP0002111_abnormal_tail_morphology1.17204594
57MP0003942_abnormal_urinary_system1.17168550
58MP0003136_yellow_coat_color1.16448687
59MP0001346_abnormal_lacrimal_gland1.16364031
60MP0000566_synostosis1.12537185
61MP0003718_maternal_effect1.11662901
62MP0006292_abnormal_olfactory_placode1.10514956
63MP0002249_abnormal_larynx_morphology1.09907314
64MP0005395_other_phenotype1.09889823
65MP0002932_abnormal_joint_morphology1.08370646
66MP0000432_abnormal_head_morphology1.08320253
67MP0000490_abnormal_crypts_of1.07802853
68MP0001286_abnormal_eye_development1.06840301
69MP0002092_abnormal_eye_morphology1.06394140
70* MP0000313_abnormal_cell_death1.05747732
71MP0001929_abnormal_gametogenesis1.04796995
72* MP0001145_abnormal_male_reproductive1.04729266
73MP0009250_abnormal_appendicular_skeleto1.04323916
74MP0006072_abnormal_retinal_apoptosis1.04058315
75MP0000631_abnormal_neuroendocrine_gland1.02047116
76MP0002282_abnormal_trachea_morphology1.00939442
77MP0002653_abnormal_ependyma_morphology0.99234585
78MP0003938_abnormal_ear_development0.98167617
79MP0000733_abnormal_muscle_development0.95279450
80MP0003699_abnormal_female_reproductive0.94185815
81MP0003941_abnormal_skin_development0.93590302
82MP0006054_spinal_hemorrhage0.92781338
83MP0001915_intracranial_hemorrhage0.92300802
84MP0002697_abnormal_eye_size0.92164800
85MP0002009_preneoplasia0.91236230
86MP0003861_abnormal_nervous_system0.91040527
87MP0002019_abnormal_tumor_incidence0.89788085
88MP0003787_abnormal_imprinting0.89781127
89* MP0000653_abnormal_sex_gland0.89396859
90MP0002114_abnormal_axial_skeleton0.88966928
91MP0002116_abnormal_craniofacial_bone0.88934277
92MP0000762_abnormal_tongue_morphology0.86465338
93MP0002233_abnormal_nose_morphology0.85177456
94MP0000647_abnormal_sebaceous_gland0.84815289
95MP0001661_extended_life_span0.84702541
96MP0004233_abnormal_muscle_weight0.83797748
97MP0003950_abnormal_plasma_membrane0.83514489
98MP0002751_abnormal_autonomic_nervous0.83281471
99MP0002160_abnormal_reproductive_system0.81807639
100MP0009278_abnormal_bone_marrow0.81597904
101MP0005391_vision/eye_phenotype0.81549214
102MP0002161_abnormal_fertility/fecundity0.80597871
103MP0004264_abnormal_extraembryonic_tissu0.80440539
104MP0002102_abnormal_ear_morphology0.80009263
105MP0008789_abnormal_olfactory_epithelium0.78744444
106MP0002109_abnormal_limb_morphology0.78608165
107MP0002925_abnormal_cardiovascular_devel0.77769579
108MP0004133_heterotaxia0.76529219
109MP0000534_abnormal_ureter_morphology0.76514403
110MP0006035_abnormal_mitochondrial_morpho0.75268601
111MP0000569_abnormal_digit_pigmentation0.74628531
112MP0001849_ear_inflammation0.73172003
113MP0000427_abnormal_hair_cycle0.73078520
114MP0005187_abnormal_penis_morphology0.72571666
115MP0005389_reproductive_system_phenotype0.72297160
116MP0001119_abnormal_female_reproductive0.72093599
117MP0010234_abnormal_vibrissa_follicle0.71934212
118MP0005248_abnormal_Harderian_gland0.71548355
119MP0001529_abnormal_vocalization0.71331862
120MP0000358_abnormal_cell_content/0.70724990
121MP0003698_abnormal_male_reproductive0.69758733
122MP0002163_abnormal_gland_morphology0.67342067
123MP0000516_abnormal_urinary_system0.66266429
124MP0005367_renal/urinary_system_phenotyp0.66266429
125MP0002081_perinatal_lethality0.65516248
126MP0000372_irregular_coat_pigmentation0.65478963
127MP0003943_abnormal_hepatobiliary_system0.63149544
128MP0001299_abnormal_eye_distance/0.59149906

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.94854476
2Short 4th metacarpal (HP:0010044)3.78269961
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.78269961
4Patellar aplasia (HP:0006443)3.40496710
5Chromsome breakage (HP:0040012)3.32058744
6Colon cancer (HP:0003003)3.28033363
7Aplasia/Hypoplasia of the patella (HP:0006498)3.25699910
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.23440654
9Selective tooth agenesis (HP:0001592)3.18168624
10Impulsivity (HP:0100710)3.13879824
11Medulloblastoma (HP:0002885)3.08920755
12Breast hypoplasia (HP:0003187)3.06340159
13Abnormal number of incisors (HP:0011064)2.94108602
14Abnormality of the labia minora (HP:0012880)2.86759811
15Meckel diverticulum (HP:0002245)2.85511119
16Volvulus (HP:0002580)2.79435119
17Abnormality of the 4th metacarpal (HP:0010012)2.79158990
18Increased nuchal translucency (HP:0010880)2.78175310
19Ectopic kidney (HP:0000086)2.78147244
20Nephroblastoma (Wilms tumor) (HP:0002667)2.76085306
21Abnormality of the ileum (HP:0001549)2.74108257
22Facial hemangioma (HP:0000329)2.67275130
23Abnormal lung lobation (HP:0002101)2.66067915
24Embryonal renal neoplasm (HP:0011794)2.64434596
25Atresia of the external auditory canal (HP:0000413)2.62122769
26Proximal placement of thumb (HP:0009623)2.59068214
27Supernumerary spleens (HP:0009799)2.56829012
28Duodenal stenosis (HP:0100867)2.55701779
29Small intestinal stenosis (HP:0012848)2.55701779
30Absent radius (HP:0003974)2.55530093
31Ependymoma (HP:0002888)2.54321998
32Abnormality of chromosome stability (HP:0003220)2.53949410
33Deviation of the thumb (HP:0009603)2.52361434
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.42540993
35Absent forearm bone (HP:0003953)2.40193865
36Aplasia involving forearm bones (HP:0009822)2.40193865
37Abdominal situs inversus (HP:0003363)2.39058507
38Abnormality of abdominal situs (HP:0011620)2.39058507
39Renal duplication (HP:0000075)2.34513322
40Aplasia/Hypoplasia of the sternum (HP:0006714)2.34189995
41Rhabdomyosarcoma (HP:0002859)2.31815562
42Abnormality of the preputium (HP:0100587)2.30155348
43Oligodactyly (hands) (HP:0001180)2.25440399
44Reticulocytopenia (HP:0001896)2.23274458
45Diastasis recti (HP:0001540)2.18100794
46Oligodactyly (HP:0012165)2.17649133
47Abnormality of the duodenum (HP:0002246)2.15952338
48High anterior hairline (HP:0009890)2.14886792
49Abnormality of the astrocytes (HP:0100707)2.13356323
50Astrocytoma (HP:0009592)2.13356323
51Short middle phalanx of the 5th finger (HP:0004220)2.11484642
52Clubbing of toes (HP:0100760)2.10854868
53Abnormality of the phalanges of the hallux (HP:0010057)2.07117966
54Short thumb (HP:0009778)2.06707573
55Duplication of thumb phalanx (HP:0009942)2.06097566
56Septo-optic dysplasia (HP:0100842)2.04907844
57Aplasia/hypoplasia of the humerus (HP:0006507)2.03369261
58Oral leukoplakia (HP:0002745)2.01966659
59Neoplasm of striated muscle (HP:0009728)2.01837488
60Glioma (HP:0009733)2.01250618
61Long eyelashes (HP:0000527)1.99463901
62Absent septum pellucidum (HP:0001331)1.98937786
63Neoplasm of the oral cavity (HP:0100649)1.98641294
64Rib fusion (HP:0000902)1.98290149
65Cortical dysplasia (HP:0002539)1.98257745
66Bifid tongue (HP:0010297)1.97792516
67Sloping forehead (HP:0000340)1.97277538
68Microvesicular hepatic steatosis (HP:0001414)1.95377370
69Choanal atresia (HP:0000453)1.95050693
70Carpal bone hypoplasia (HP:0001498)1.94582603
71Supernumerary bones of the axial skeleton (HP:0009144)1.93708774
72Duplicated collecting system (HP:0000081)1.92551465
73Broad thumb (HP:0011304)1.92308201
74Neoplasm of the pancreas (HP:0002894)1.92254736
75Supernumerary ribs (HP:0005815)1.92240656
76Myelodysplasia (HP:0002863)1.91978565
77Degeneration of anterior horn cells (HP:0002398)1.90779652
78Abnormality of the anterior horn cell (HP:0006802)1.90779652
79Bilateral microphthalmos (HP:0007633)1.90756470
80Abnormality of the septum pellucidum (HP:0007375)1.88684585
81Abnormality of the carotid arteries (HP:0005344)1.88342252
82Tracheoesophageal fistula (HP:0002575)1.87132441
83Short humerus (HP:0005792)1.86932985
84Hyperglycinemia (HP:0002154)1.86217045
85Shawl scrotum (HP:0000049)1.85184255
86Broad phalanges of the hand (HP:0009768)1.84165178
87Abnormality of cochlea (HP:0000375)1.84023573
88Horseshoe kidney (HP:0000085)1.83006835
89Triphalangeal thumb (HP:0001199)1.82357101
90Prominent nose (HP:0000448)1.81429556
91Short 5th finger (HP:0009237)1.81288153
92Overlapping toe (HP:0001845)1.79786484
93Microglossia (HP:0000171)1.79548859
94Microtia (HP:0008551)1.79451035
95Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79023178
96Pelvic girdle muscle weakness (HP:0003749)1.78551142
97Abnormality of methionine metabolism (HP:0010901)1.78128280
98High pitched voice (HP:0001620)1.77841626
99Neoplasm of the colon (HP:0100273)1.77592337
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77017369
101Facial cleft (HP:0002006)1.76666933
102Absent thumb (HP:0009777)1.76300412
103Abnormality of DNA repair (HP:0003254)1.75018266
104Megaloblastic anemia (HP:0001889)1.74060402
105Premature graying of hair (HP:0002216)1.72527849
106Hepatoblastoma (HP:0002884)1.72181502
107Preauricular skin tag (HP:0000384)1.71877050
108Skin tags (HP:0010609)1.71874064
109Malignant gastrointestinal tract tumors (HP:0006749)1.71638230
110Gastrointestinal carcinoma (HP:0002672)1.71638230
111Rough bone trabeculation (HP:0100670)1.71128317
112Abnormality of the renal collecting system (HP:0004742)1.70807568
113Preaxial hand polydactyly (HP:0001177)1.70087769
114Broad finger (HP:0001500)1.69860299
115Agnosia (HP:0010524)1.69728199
116Short tibia (HP:0005736)1.69712797
117Cafe-au-lait spot (HP:0000957)1.69649442
118Syringomyelia (HP:0003396)1.69616542
119Spinal cord lesions (HP:0100561)1.69616542
120Shallow orbits (HP:0000586)1.69010722
121Multiple enchondromatosis (HP:0005701)1.68601837
122Capillary hemangiomas (HP:0005306)1.68253073
123Skull defect (HP:0001362)1.67860176
124Partial agenesis of the corpus callosum (HP:0001338)1.67786070
125Esophageal atresia (HP:0002032)1.66540171
126Arteriovenous malformation (HP:0100026)1.65826557
127Increased serum pyruvate (HP:0003542)1.65735289
128Trigonocephaly (HP:0000243)1.65685212
129Hyperalaninemia (HP:0003348)1.61840388
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61840388
131Abnormality of alanine metabolism (HP:0010916)1.61840388
132Hypoplastic pelvis (HP:0008839)1.61812535
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.61797672
134Abnormality of glycolysis (HP:0004366)1.59953990
135Bicornuate uterus (HP:0000813)1.59615321
136Gastrointestinal atresia (HP:0002589)1.58452903
137Cleft eyelid (HP:0000625)1.56615688
138Abnormality of the pons (HP:0007361)1.56371657
139Macrocytic anemia (HP:0001972)1.55480841
140Abnormality of serum amino acid levels (HP:0003112)1.54893131
141Premature ovarian failure (HP:0008209)1.53152116
142Hypoplasia of the pons (HP:0012110)1.52097456
143Intestinal atresia (HP:0011100)1.51863805
144Dandy-Walker malformation (HP:0001305)1.51383303
145Gonadotropin excess (HP:0000837)1.51358086
146Abnormality of chromosome segregation (HP:0002916)1.50661622
147Embryonal neoplasm (HP:0002898)1.50091050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.14108833
2BUB14.04155122
3WEE13.99760064
4NEK23.39270160
5PBK2.80359967
6TTK2.72975107
7SRPK12.70805455
8MKNK12.45664257
9PLK42.37267958
10CDK122.36426051
11BRSK22.31362181
12EIF2AK12.26719847
13NEK12.22681833
14PLK12.20982530
15ACVR1B2.15553359
16PLK31.90877552
17NUAK11.90701080
18VRK21.90671791
19ATR1.83505368
20TSSK61.82866483
21CDK71.82654441
22AURKB1.79919992
23CHEK21.77892944
24MKNK21.76068752
25LATS11.74788584
26DYRK31.63351539
27CCNB11.60262332
28RPS6KA41.55318956
29BRSK11.53913887
30CHEK11.49691208
31PASK1.49525368
32CDK41.45241083
33STK31.35361351
34MAP3K101.34264331
35MAP3K81.33942574
36BRD41.30192198
37LATS21.27964446
38BMPR1B1.25367266
39TGFBR11.23864884
40TRIM281.21796407
41RPS6KB21.21474124
42PAK41.19404443
43STK101.17934537
44TAF11.16627660
45VRK11.15210942
46NME11.14237633
47MELK1.14145112
48AURKA1.11340185
49ATM1.11333004
50EEF2K1.10686931
51STK38L1.08927330
52STK41.08729151
53CDK61.07547232
54TESK21.06908921
55* CDK21.05526007
56EIF2AK31.02238831
57TLK10.98710151
58ICK0.98120807
59CDK10.89756572
60MET0.86250137
61ZAK0.83028413
62STK390.80559995
63EPHA20.78038453
64SCYL20.78017015
65MTOR0.76793604
66EIF2AK20.75524703
67PNCK0.74596086
68WNK40.74209161
69MAP3K90.72701054
70FLT30.71868131
71TESK10.70015672
72ALK0.68549147
73PDK20.68351939
74MST40.66922256
75TNIK0.66507793
76CDK80.63626384
77WNK30.63528524
78NME20.60578795
79CSNK2A20.59052277
80MAP4K20.58137514
81CSNK2A10.56676293
82PAK20.56290760
83INSRR0.56131993
84MAP3K40.55361724
85FGFR10.55035388
86PAK10.54847137
87CSNK1E0.51692310
88MUSK0.50236780
89ERBB40.49665208
90CAMK1D0.48475087
91CSNK1G20.48400088
92PKN20.47704961
93MAPKAPK50.47188048
94PRKDC0.47177273
95AKT20.46783121
96RAF10.45940391
97PDK30.45507797
98PDK40.45507797
99BCR0.44831990
100CLK10.43527882
101OXSR10.42771290
102STK240.41728372
103MAPK140.41082823
104YES10.40890875
105ERBB30.40125755
106DDR20.39497777
107CSNK1A1L0.38460291
108LRRK20.38222338
109AKT30.36930415
110CAMK1G0.36702402
111CSNK1G30.35673669
112ARAF0.35563094
113CDK190.34456475
114AKT10.34125362
115CSNK1D0.33765083
116TAOK20.33016539
117CDK30.32062241
118GSK3B0.32033290
119CSNK1G10.31399903
120DYRK20.30212053
121PDGFRA0.30106837
122RPS6KA50.28523017
123PLK20.28504096
124CDK90.27937910
125STK160.27576967
126PTK60.26355361
127PRKCI0.26131928
128KDR0.25648795
129TTN0.24157923
130MAPK10.24131643
131BRAF0.22015362
132EPHB20.21815275

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.17751943
2Mismatch repair_Homo sapiens_hsa034304.35465588
3* Cell cycle_Homo sapiens_hsa041103.61820506
4RNA transport_Homo sapiens_hsa030133.52613208
5Spliceosome_Homo sapiens_hsa030403.51940208
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51203778
7Base excision repair_Homo sapiens_hsa034103.05818609
8Homologous recombination_Homo sapiens_hsa034402.94780228
9Nucleotide excision repair_Homo sapiens_hsa034202.80869889
10One carbon pool by folate_Homo sapiens_hsa006702.58121696
11RNA polymerase_Homo sapiens_hsa030202.51494995
12Fanconi anemia pathway_Homo sapiens_hsa034602.48743672
13mRNA surveillance pathway_Homo sapiens_hsa030152.27162865
14Pyrimidine metabolism_Homo sapiens_hsa002402.16671379
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15425988
16Ribosome_Homo sapiens_hsa030102.08141138
17Non-homologous end-joining_Homo sapiens_hsa034502.04814455
18RNA degradation_Homo sapiens_hsa030181.98298340
19p53 signaling pathway_Homo sapiens_hsa041151.94784364
20Proteasome_Homo sapiens_hsa030501.93952075
21Basal transcription factors_Homo sapiens_hsa030221.83879081
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64222183
23Systemic lupus erythematosus_Homo sapiens_hsa053221.57562657
24Oocyte meiosis_Homo sapiens_hsa041141.56312585
25Basal cell carcinoma_Homo sapiens_hsa052171.43734366
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42959074
27* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37596411
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28400848
29MicroRNAs in cancer_Homo sapiens_hsa052061.27079076
30Protein export_Homo sapiens_hsa030601.24464572
31Pyruvate metabolism_Homo sapiens_hsa006201.22675255
32Hippo signaling pathway_Homo sapiens_hsa043901.19038476
33Hedgehog signaling pathway_Homo sapiens_hsa043401.18133386
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18086342
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17586726
36Purine metabolism_Homo sapiens_hsa002301.16469429
37* Viral carcinogenesis_Homo sapiens_hsa052031.15041333
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10511414
39Propanoate metabolism_Homo sapiens_hsa006401.10362866
40* Epstein-Barr virus infection_Homo sapiens_hsa051691.09150330
41Vitamin B6 metabolism_Homo sapiens_hsa007501.05943414
42HTLV-I infection_Homo sapiens_hsa051661.02876706
43Steroid biosynthesis_Homo sapiens_hsa001001.02531748
44Fatty acid elongation_Homo sapiens_hsa000621.02457037
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02289132
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99676115
47TGF-beta signaling pathway_Homo sapiens_hsa043500.97800627
48Huntingtons disease_Homo sapiens_hsa050160.89309249
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87835508
50Parkinsons disease_Homo sapiens_hsa050120.87673744
51* Small cell lung cancer_Homo sapiens_hsa052220.87571512
52Sulfur relay system_Homo sapiens_hsa041220.87492102
53* Herpes simplex infection_Homo sapiens_hsa051680.81003264
54Adherens junction_Homo sapiens_hsa045200.79724115
55Oxidative phosphorylation_Homo sapiens_hsa001900.79478402
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79069793
57Thyroid cancer_Homo sapiens_hsa052160.78421576
58Colorectal cancer_Homo sapiens_hsa052100.76163124
59Alcoholism_Homo sapiens_hsa050340.75351075
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71812176
61Biosynthesis of amino acids_Homo sapiens_hsa012300.71596893
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66794683
63Antigen processing and presentation_Homo sapiens_hsa046120.66375771
64Wnt signaling pathway_Homo sapiens_hsa043100.66279154
65Selenocompound metabolism_Homo sapiens_hsa004500.63922753
66Notch signaling pathway_Homo sapiens_hsa043300.61886310
67Lysine degradation_Homo sapiens_hsa003100.61208920
68Prostate cancer_Homo sapiens_hsa052150.59745882
69Chronic myeloid leukemia_Homo sapiens_hsa052200.59059385
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.59034448
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58737120
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57916848
73* Pathways in cancer_Homo sapiens_hsa052000.52747309
74Metabolic pathways_Homo sapiens_hsa011000.52679464
75mTOR signaling pathway_Homo sapiens_hsa041500.50832946
76Pentose phosphate pathway_Homo sapiens_hsa000300.50326556
77Bladder cancer_Homo sapiens_hsa052190.50257252
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49486292
79Proteoglycans in cancer_Homo sapiens_hsa052050.47310314
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45208383
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45011241
82Viral myocarditis_Homo sapiens_hsa054160.43602413
83Hepatitis B_Homo sapiens_hsa051610.42647916
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42325540
85Endometrial cancer_Homo sapiens_hsa052130.41278494
86Butanoate metabolism_Homo sapiens_hsa006500.40829521
87Tight junction_Homo sapiens_hsa045300.40316358
88Arginine biosynthesis_Homo sapiens_hsa002200.39462740
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.38036085
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37799832
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.37739723
92Fatty acid metabolism_Homo sapiens_hsa012120.37413630
93Non-small cell lung cancer_Homo sapiens_hsa052230.37310676
94Arginine and proline metabolism_Homo sapiens_hsa003300.36856208
95Alzheimers disease_Homo sapiens_hsa050100.36163131
96Legionellosis_Homo sapiens_hsa051340.36063564
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35999093
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35700054
99Caffeine metabolism_Homo sapiens_hsa002320.35308563
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35156932
101Melanoma_Homo sapiens_hsa052180.33121115
102Vitamin digestion and absorption_Homo sapiens_hsa049770.32002904
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30820279
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29155533
105HIF-1 signaling pathway_Homo sapiens_hsa040660.28668822
106Nitrogen metabolism_Homo sapiens_hsa009100.28278350
107Apoptosis_Homo sapiens_hsa042100.27578964
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27189731
109Renin-angiotensin system_Homo sapiens_hsa046140.26392929
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26373550
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26091742
112Folate biosynthesis_Homo sapiens_hsa007900.25983501
113Pancreatic cancer_Homo sapiens_hsa052120.25482791
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24556111
115N-Glycan biosynthesis_Homo sapiens_hsa005100.24456945
116Phototransduction_Homo sapiens_hsa047440.23462194
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.22658161
118* FoxO signaling pathway_Homo sapiens_hsa040680.22090519
119Olfactory transduction_Homo sapiens_hsa047400.21821595
120Carbon metabolism_Homo sapiens_hsa012000.19865323
121Peroxisome_Homo sapiens_hsa041460.19817490
122Glutathione metabolism_Homo sapiens_hsa004800.19675371
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19637508
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.19501332
125Sulfur metabolism_Homo sapiens_hsa009200.19439851
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17514187
127Shigellosis_Homo sapiens_hsa051310.16909037
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16169515
129Focal adhesion_Homo sapiens_hsa045100.15065938
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13405640
131Tryptophan metabolism_Homo sapiens_hsa003800.13156883
132Renal cell carcinoma_Homo sapiens_hsa052110.12295036
133AMPK signaling pathway_Homo sapiens_hsa041520.10881034
134Glioma_Homo sapiens_hsa052140.10835365
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10712508
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09408702
137Measles_Homo sapiens_hsa051620.08922874
138ECM-receptor interaction_Homo sapiens_hsa045120.07965680
139Melanogenesis_Homo sapiens_hsa049160.07664483
140Influenza A_Homo sapiens_hsa051640.07582980
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.06203650
142Acute myeloid leukemia_Homo sapiens_hsa052210.03827926
143Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.02638479

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