SIRT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.35321705
2L-phenylalanine catabolic process (GO:0006559)6.35321705
3L-phenylalanine metabolic process (GO:0006558)6.14202678
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.14202678
5aromatic amino acid family catabolic process (GO:0009074)5.74778275
6indole-containing compound catabolic process (GO:0042436)5.29081737
7indolalkylamine catabolic process (GO:0046218)5.29081737
8tryptophan catabolic process (GO:0006569)5.29081737
9kynurenine metabolic process (GO:0070189)4.91372382
10tryptophan metabolic process (GO:0006568)4.89287086
11bile acid biosynthetic process (GO:0006699)4.81352546
12glyoxylate metabolic process (GO:0046487)4.76961479
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.44913036
14fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.41144649
15synaptic vesicle maturation (GO:0016188)4.38979675
16alpha-linolenic acid metabolic process (GO:0036109)4.22704399
17coenzyme catabolic process (GO:0009109)4.22206401
18creatine metabolic process (GO:0006600)4.14635646
19synaptonemal complex assembly (GO:0007130)4.12554297
20amino-acid betaine metabolic process (GO:0006577)4.12310157
21aromatic amino acid family metabolic process (GO:0009072)4.12116175
22cellular ketone body metabolic process (GO:0046950)4.02566874
23regulation of cholesterol esterification (GO:0010872)4.01768759
24high-density lipoprotein particle remodeling (GO:0034375)3.98527596
25cysteine metabolic process (GO:0006534)3.97251062
26alpha-amino acid catabolic process (GO:1901606)3.94218298
27bile acid metabolic process (GO:0008206)3.91599635
28sulfur amino acid catabolic process (GO:0000098)3.91315055
29oxaloacetate metabolic process (GO:0006107)3.91024173
30amine catabolic process (GO:0009310)3.89918023
31cellular biogenic amine catabolic process (GO:0042402)3.89918023
32neuronal action potential propagation (GO:0019227)3.89324131
33synaptonemal complex organization (GO:0070193)3.81549639
34NAD biosynthetic process (GO:0009435)3.79850084
35glutamate metabolic process (GO:0006536)3.77923639
36indolalkylamine metabolic process (GO:0006586)3.77359751
37regulation of fibrinolysis (GO:0051917)3.74085309
38lysine metabolic process (GO:0006553)3.73353944
39lysine catabolic process (GO:0006554)3.73353944
40low-density lipoprotein particle remodeling (GO:0034374)3.70927288
41cellular amino acid catabolic process (GO:0009063)3.69744387
42urea metabolic process (GO:0019627)3.67177109
43urea cycle (GO:0000050)3.67177109
44blood coagulation, intrinsic pathway (GO:0007597)3.67051033
45serine family amino acid catabolic process (GO:0009071)3.66273843
46chromosome organization involved in meiosis (GO:0070192)3.66218306
47NAD metabolic process (GO:0019674)3.65907220
48succinate metabolic process (GO:0006105)3.65576567
49cofactor catabolic process (GO:0051187)3.64048047
50short-chain fatty acid metabolic process (GO:0046459)3.63962904
51synapsis (GO:0007129)3.62546476
52plasma lipoprotein particle remodeling (GO:0034369)3.61145964
53protein-lipid complex remodeling (GO:0034368)3.61145964
54macromolecular complex remodeling (GO:0034367)3.61145964
55positive regulation of mitochondrial fission (GO:0090141)3.57224187
56regulation of triglyceride catabolic process (GO:0010896)3.56940548
57dicarboxylic acid biosynthetic process (GO:0043650)3.55526119
58tyrosine metabolic process (GO:0006570)3.55132363
59carnitine metabolic process (GO:0009437)3.53933605
60drug transmembrane transport (GO:0006855)3.50122675
61branched-chain amino acid catabolic process (GO:0009083)3.49705478
62ethanol oxidation (GO:0006069)3.49078693
63valine metabolic process (GO:0006573)3.48788810
64male meiosis I (GO:0007141)3.48775111
65negative regulation of fibrinolysis (GO:0051918)3.48606044
662-oxoglutarate metabolic process (GO:0006103)3.48137091
67flavonoid metabolic process (GO:0009812)3.47083645
68nitrogen cycle metabolic process (GO:0071941)3.45970754
69pyridine nucleotide biosynthetic process (GO:0019363)3.45019564
70nicotinamide nucleotide biosynthetic process (GO:0019359)3.45019564
71ketone body metabolic process (GO:1902224)3.44977345
72benzene-containing compound metabolic process (GO:0042537)3.44307241
73DNA synthesis involved in DNA repair (GO:0000731)3.43385451
74carboxylic acid catabolic process (GO:0046395)3.42294777
75organic acid catabolic process (GO:0016054)3.42294777
76aldehyde catabolic process (GO:0046185)3.41227233
77imidazole-containing compound metabolic process (GO:0052803)3.40258380
78opsonization (GO:0008228)3.37964751
79fatty acid catabolic process (GO:0009062)3.35556973
80synaptic vesicle docking involved in exocytosis (GO:0016081)3.35187973
81fatty acid beta-oxidation (GO:0006635)3.35144829
82monocarboxylic acid catabolic process (GO:0072329)3.34344364
83peroxisome fission (GO:0016559)3.34272655
84postsynaptic membrane organization (GO:0001941)3.33285707
85fatty acid oxidation (GO:0019395)3.31787357
86synaptic vesicle exocytosis (GO:0016079)3.30664641
87neurotransmitter-gated ion channel clustering (GO:0072578)3.30637550
88reverse cholesterol transport (GO:0043691)3.30494385
89complement activation, alternative pathway (GO:0006957)3.28894893
90protein carboxylation (GO:0018214)3.28525583
91peptidyl-glutamic acid carboxylation (GO:0017187)3.28525583
92cellular modified amino acid catabolic process (GO:0042219)3.28444866
93regulation of protein activation cascade (GO:2000257)3.27617838
94glutamate secretion (GO:0014047)3.27554427
95ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.27386434
96neurotransmitter catabolic process (GO:0042135)3.26687271
97lipid oxidation (GO:0034440)3.26529121
98branched-chain amino acid metabolic process (GO:0009081)3.24609008
99platelet dense granule organization (GO:0060155)3.21038123
100phospholipid efflux (GO:0033700)3.20349881
101establishment of mitochondrion localization (GO:0051654)3.20272133
102very long-chain fatty acid metabolic process (GO:0000038)3.18798572
103aspartate family amino acid catabolic process (GO:0009068)3.15665858
104acetyl-CoA metabolic process (GO:0006084)3.15197944
105NADH metabolic process (GO:0006734)3.14833795
106bile acid and bile salt transport (GO:0015721)3.13972535
107triglyceride homeostasis (GO:0070328)3.12852686
108acylglycerol homeostasis (GO:0055090)3.12852686
109serine family amino acid metabolic process (GO:0009069)3.12370202
110mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.10515017
111serine family amino acid biosynthetic process (GO:0009070)3.10470455
112actin-myosin filament sliding (GO:0033275)3.10301443
113muscle filament sliding (GO:0030049)3.10301443
114urate metabolic process (GO:0046415)3.09437546
115drug transport (GO:0015893)3.07716053
116disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.07400778
117killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.07400778
118indole-containing compound metabolic process (GO:0042430)3.05156686
119axonemal dynein complex assembly (GO:0070286)3.04181472
120dicarboxylic acid catabolic process (GO:0043649)3.02153828
121epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01940133
122small molecule catabolic process (GO:0044282)3.01918938
123homocysteine metabolic process (GO:0050667)3.00448939
124cilium or flagellum-dependent cell motility (GO:0001539)3.00274784
125meiosis I (GO:0007127)2.96817767
126gluconeogenesis (GO:0006094)2.87457337
127regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.80002078
128regulation of synaptic vesicle exocytosis (GO:2000300)2.78292591
129membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.76434722
130auditory behavior (GO:0031223)2.73488924
131mitochondrion transport along microtubule (GO:0047497)2.72618025
132establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.72618025
133regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70367193
134intraciliary transport (GO:0042073)2.69430582
135positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.66479381
136pyrimidine nucleobase catabolic process (GO:0006208)2.66453849
137histone H4 deacetylation (GO:0070933)2.64768641
138regulation of skeletal muscle contraction (GO:0014819)2.62694397
139positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.60114261
140hexose biosynthetic process (GO:0019319)2.58977735
141tricarboxylic acid cycle (GO:0006099)2.57742699
142ADP metabolic process (GO:0046031)2.57216688
143synaptic vesicle endocytosis (GO:0048488)2.55515818
144cilium movement (GO:0003341)2.54148479
145sarcoplasmic reticulum calcium ion transport (GO:0070296)2.53953083
146axonal fasciculation (GO:0007413)2.53620041
147cerebellar granule cell differentiation (GO:0021707)2.53317165
148positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.52994849
149histone H2A acetylation (GO:0043968)2.52439903
150response to auditory stimulus (GO:0010996)2.52071213
151ubiquinone biosynthetic process (GO:0006744)2.51055767
152striated muscle contraction (GO:0006941)2.50911810
153neurotransmitter secretion (GO:0007269)2.50163274
154monosaccharide biosynthetic process (GO:0046364)2.49986843
155neuromuscular synaptic transmission (GO:0007274)2.48200190
156regulation of mitochondrial fission (GO:0090140)2.46941155
157embryonic camera-type eye development (GO:0031076)2.44661971
158regulation of cilium movement (GO:0003352)2.44201143
159nonmotile primary cilium assembly (GO:0035058)2.44024298
160cardiac muscle contraction (GO:0060048)2.43319319
161actin-mediated cell contraction (GO:0070252)2.43217684
162layer formation in cerebral cortex (GO:0021819)2.42830978
163peptidyl-arginine N-methylation (GO:0035246)2.42575223
164peptidyl-arginine methylation (GO:0018216)2.42575223
165meiotic nuclear division (GO:0007126)2.42061478
166glycogen catabolic process (GO:0005980)2.40363310
167cellular potassium ion homeostasis (GO:0030007)2.40038934
168regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.37758450
169otic vesicle formation (GO:0030916)2.35286480
170skeletal muscle fiber development (GO:0048741)2.35281492
171neuronal ion channel clustering (GO:0045161)2.34904632
172skeletal muscle contraction (GO:0003009)2.34688380
173cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.34559248
174acidic amino acid transport (GO:0015800)2.33052677
175phenol-containing compound catabolic process (GO:0019336)2.32897443
176male meiosis (GO:0007140)2.32250971
177regulation of microtubule-based movement (GO:0060632)2.29584706
178L-glutamate transport (GO:0015813)2.28884379
179cell migration in hindbrain (GO:0021535)2.28540618
180protein localization to synapse (GO:0035418)2.27222932
181ionotropic glutamate receptor signaling pathway (GO:0035235)2.26625771
182regulation of synaptic vesicle transport (GO:1902803)2.26566035
183base-excision repair, AP site formation (GO:0006285)2.26259773
184mitochondrion degradation (GO:0000422)2.25480896
185C4-dicarboxylate transport (GO:0015740)2.25369423
186cardiac myofibril assembly (GO:0055003)2.24174265
187regulation of neurotransmitter levels (GO:0001505)2.23596204
188short-term memory (GO:0007614)2.23017942
189positive regulation of meiosis (GO:0045836)2.22838527
190quinone biosynthetic process (GO:1901663)2.21373040

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.02969719
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.37491459
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.27687698
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.27858177
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.92369053
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.71607479
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.70989660
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.50676598
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.48229116
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.05167771
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.92765874
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85500556
13SCL_19346495_ChIP-Seq_HPC-7_Human2.72539569
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.52350931
15TAF15_26573619_Chip-Seq_HEK293_Human2.43793500
16GATA1_22025678_ChIP-Seq_K562_Human2.27609384
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10935890
18GBX2_23144817_ChIP-Seq_PC3_Human2.07795114
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07746197
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07361809
21P68_20966046_ChIP-Seq_HELA_Human1.97804743
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96135823
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93040010
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.91537867
25LXR_22292898_ChIP-Seq_THP-1_Human1.90458069
26CTCF_27219007_Chip-Seq_Bcells_Human1.87388625
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.86812023
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.85904001
29HTT_18923047_ChIP-ChIP_STHdh_Human1.83048817
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.80025617
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.79141783
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79074957
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78669950
34* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.75066719
35* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74928124
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74323318
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.70689666
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67646964
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65859366
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65535703
41SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.64176648
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.60704493
43DROSHA_22980978_ChIP-Seq_HELA_Human1.57928831
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.54286990
45SMC4_20622854_ChIP-Seq_HELA_Human1.53751059
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.51839254
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49221542
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.49090124
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46398001
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44710922
51BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42504127
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.42194637
53SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.41797181
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.40277148
55IRF1_19129219_ChIP-ChIP_H3396_Human1.39701812
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.36581381
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35063796
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35061734
59FOXP1_21924763_ChIP-Seq_HESCs_Human1.34492128
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32907085
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31706332
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30974756
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30805287
64BCL6_27268052_Chip-Seq_Bcells_Human1.29413114
65* PHF8_20622854_ChIP-Seq_HELA_Human1.29132062
66* TET1_21490601_ChIP-Seq_MESCs_Mouse1.28809347
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25512742
68KDM2B_26808549_Chip-Seq_K562_Human1.24593312
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24439992
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24433310
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24108154
72CREB1_26743006_Chip-Seq_LNCaP_Human1.23493084
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.22866037
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22580323
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.22381950
76* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21377526
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20148125
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20083957
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.20064086
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.19898397
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19156615
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19139960
83* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18360765
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18179227
85KDM2B_26808549_Chip-Seq_DND41_Human1.15699918
86SOX3_22085726_ChIP-Seq_NPCs_Mouse1.15304343
87BCOR_27268052_Chip-Seq_Bcells_Human1.14600996
88* SA1_27219007_Chip-Seq_Bcells_Human1.13822451
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12712996
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12623971
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11725300
92RNF2_27304074_Chip-Seq_ESCs_Mouse1.11650202
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11346702
94XRN2_22483619_ChIP-Seq_HELA_Human1.10626870
95RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09001293
96OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06405134
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05483912
98MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05351727
99EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04789327
100RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04789327
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03975840
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03603710
103AR_20517297_ChIP-Seq_VCAP_Human1.03273297
104RARA_24833708_ChIP-Seq_LIVER_Mouse1.03249139
105KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02947531
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01780515
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01094592
108* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00901877
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99797187
110* GABP_19822575_ChIP-Seq_HepG2_Human0.99259228
111EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98565432
112E2F1_20622854_ChIP-Seq_HELA_Human0.96849812
113ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96830491
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.96640252
115OCT4_19829295_ChIP-Seq_ESCs_Human0.95726171
116CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93561311
117CTCF_21964334_Chip-Seq_Bcells_Human0.93389430
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92777586
119NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92377467
120CTCF_20526341_ChIP-Seq_ESCs_Human0.92334609
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92317109
122JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91797237
123IGF1R_20145208_ChIP-Seq_DFB_Human0.91335079
124TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90913697
125RARB_24833708_ChIP-Seq_LIVER_Mouse0.90217173
126ERG_20517297_ChIP-Seq_VCAP_Human0.90128739
127SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89499610
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89146276
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88195537
130CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87491638
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86695049
132BP1_19119308_ChIP-ChIP_Hs578T_Human0.86417603
133ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85785605
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.85526042
135HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85244010
136POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85023024
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83695667
138SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83491262
139BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82887841
140EST1_17652178_ChIP-ChIP_JURKAT_Human0.82781707
141RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81653458
142MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81632022
143AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80271245
144P300_19829295_ChIP-Seq_ESCs_Human0.80136873
145CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79685617
146TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79012064
147FOXP3_21729870_ChIP-Seq_TREG_Human0.78805099
148RUNX1_27457419_Chip-Seq_LIVER_Mouse0.77060873
149TAL1_26923725_Chip-Seq_HPCs_Mouse0.76329785
150RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75165395
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75142214
152REST_18959480_ChIP-ChIP_MESCs_Mouse0.74734570
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.73978655
154THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73336750
155REST_21632747_ChIP-Seq_MESCs_Mouse0.71599946
156SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71510780
157STAT1_17558387_ChIP-Seq_HELA_Human0.70782374
158CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70536374
159KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70192003
160PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69775340
161SOX2_22085726_ChIP-Seq_NPCs_Mouse0.68833818
162NFE2_27457419_Chip-Seq_LIVER_Mouse0.68702608
163EZH2_22144423_ChIP-Seq_EOC_Human0.68442578
164SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.68228560
165EZH2_27294783_Chip-Seq_NPCs_Mouse0.68174735
166* TAF2_19829295_ChIP-Seq_ESCs_Human0.68086281
167SUZ12_27294783_Chip-Seq_NPCs_Mouse0.67932190
168PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.67629471
169HNF4A_19822575_ChIP-Seq_HepG2_Human0.67128882
170IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.66662541
171CBP_20019798_ChIP-Seq_JUKART_Human0.66662541
172PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.66632223
173CTBP2_25329375_ChIP-Seq_LNCAP_Human0.64993767
174GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.63868972
175SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63268009
176ESET_19884257_ChIP-Seq_ESCs_Mouse0.62691966
177FUS_26573619_Chip-Seq_HEK293_Human0.62438004
178GABP_17652178_ChIP-ChIP_JURKAT_Human0.62146257
179ETV2_25802403_ChIP-Seq_MESCs_Mouse0.61959477
180NANOG_19829295_ChIP-Seq_ESCs_Human0.61543382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.29888401
2MP0005360_urolithiasis5.63252186
3MP0005085_abnormal_gallbladder_physiolo5.15075366
4MP0005365_abnormal_bile_salt4.90655475
5MP0008875_abnormal_xenobiotic_pharmacok4.85112978
6MP0003806_abnormal_nucleotide_metabolis3.29773171
7MP0005423_abnormal_somatic_nervous3.17489606
8MP0000751_myopathy3.11741054
9MP0010329_abnormal_lipoprotein_level2.86705511
10MP0002653_abnormal_ependyma_morphology2.57418533
11MP0003252_abnormal_bile_duct2.48523633
12MP0005332_abnormal_amino_acid2.45391195
13MP0003195_calcinosis2.29355553
14MP0004145_abnormal_muscle_electrophysio2.23254315
15MP0008789_abnormal_olfactory_epithelium2.20150491
16MP0009697_abnormal_copulation2.17831102
17MP0005083_abnormal_biliary_tract2.11456711
18MP0001764_abnormal_homeostasis2.08415726
19MP0005394_taste/olfaction_phenotype2.00082705
20MP0005499_abnormal_olfactory_system2.00082705
21MP0004270_analgesia1.99208622
22MP0004885_abnormal_endolymph1.97268799
23* MP0006036_abnormal_mitochondrial_physio1.96220051
24MP0009840_abnormal_foam_cell1.95541984
25MP0000749_muscle_degeneration1.95316887
26MP0001666_abnormal_nutrient_absorption1.90501973
27MP0008877_abnormal_DNA_methylation1.86779537
28MP0003868_abnormal_feces_composition1.82755577
29MP0001986_abnormal_taste_sensitivity1.82209087
30MP0005584_abnormal_enzyme/coenzyme_acti1.80768025
31MP0000778_abnormal_nervous_system1.78966033
32MP0002118_abnormal_lipid_homeostasis1.76127598
33MP0004019_abnormal_vitamin_homeostasis1.73954699
34MP0003191_abnormal_cellular_cholesterol1.73089665
35MP0004147_increased_porphyrin_level1.72284047
36MP0002876_abnormal_thyroid_physiology1.71383312
37MP0008569_lethality_at_weaning1.67607500
38MP0003122_maternal_imprinting1.65994806
39MP0005319_abnormal_enzyme/_coenzyme1.63434480
40MP0002249_abnormal_larynx_morphology1.57592391
41MP0002734_abnormal_mechanical_nocicepti1.51549170
42MP0005330_cardiomyopathy1.47022149
43MP0001502_abnormal_circadian_rhythm1.46655331
44MP0000609_abnormal_liver_physiology1.45377432
45MP0005084_abnormal_gallbladder_morpholo1.43362892
46MP0003656_abnormal_erythrocyte_physiolo1.43069436
47MP0009379_abnormal_foot_pigmentation1.43041836
48MP0010030_abnormal_orbit_morphology1.41506947
49MP0005075_abnormal_melanosome_morpholog1.37836491
50MP0006035_abnormal_mitochondrial_morpho1.37280322
51MP0001299_abnormal_eye_distance/1.36277459
52MP0005646_abnormal_pituitary_gland1.35751788
53MP0004142_abnormal_muscle_tone1.34286009
54MP0003011_delayed_dark_adaptation1.32286136
55MP0002837_dystrophic_cardiac_calcinosis1.31882561
56MP0003186_abnormal_redox_activity1.26861301
57MP0005464_abnormal_platelet_physiology1.26501478
58MP0004133_heterotaxia1.24839292
59MP0002822_catalepsy1.23730226
60MP0000566_synostosis1.23581034
61MP0002736_abnormal_nociception_after1.22489290
62MP0005535_abnormal_body_temperature1.21632715
63MP0000955_abnormal_spinal_cord1.21095604
64MP0002638_abnormal_pupillary_reflex1.20892135
65MP0005636_abnormal_mineral_homeostasis1.20395534
66MP0009745_abnormal_behavioral_response1.19927238
67MP0004087_abnormal_muscle_fiber1.18403234
68MP0003880_abnormal_central_pattern1.16933316
69MP0008872_abnormal_physiological_respon1.14704540
70MP0002106_abnormal_muscle_physiology1.14035031
71MP0003724_increased_susceptibility_to1.13599632
72MP0004811_abnormal_neuron_physiology1.12447141
73MP0000747_muscle_weakness1.11490016
74MP0002066_abnormal_motor_capabilities/c1.11486591
75MP0002882_abnormal_neuron_morphology1.10369107
76MP0002138_abnormal_hepatobiliary_system1.06680198
77MP0003137_abnormal_impulse_conducting1.06401014
78MP0000678_abnormal_parathyroid_gland1.06221459
79MP0002152_abnormal_brain_morphology1.06199725
80MP0006138_congestive_heart_failure1.05604501
81MP0008058_abnormal_DNA_repair1.04788947
82MP0001968_abnormal_touch/_nociception1.03420390
83MP0003329_amyloid_beta_deposits1.03363985
84MP0000750_abnormal_muscle_regeneration1.01091006
85MP0000759_abnormal_skeletal_muscle1.01063960
86MP0004036_abnormal_muscle_relaxation1.00705591
87MP0008775_abnormal_heart_ventricle0.99991301
88MP0009643_abnormal_urine_homeostasis0.99795096
89MP0003698_abnormal_male_reproductive0.99331675
90MP0005369_muscle_phenotype0.99112012
91MP0001970_abnormal_pain_threshold0.98894829
92MP0004858_abnormal_nervous_system0.98168280
93MP0004215_abnormal_myocardial_fiber0.97909588
94MP0001963_abnormal_hearing_physiology0.97369485
95MP0000026_abnormal_inner_ear0.97144047
96MP0002557_abnormal_social/conspecific_i0.96728573
97MP0008874_decreased_physiological_sensi0.95856764
98MP0002272_abnormal_nervous_system0.95663310
99MP0008469_abnormal_protein_level0.95107158
100MP0002733_abnormal_thermal_nociception0.93244222
101MP0005647_abnormal_sex_gland0.92673338
102MP0002064_seizures0.92128717
103MP0001188_hyperpigmentation0.91643426
104MP0001905_abnormal_dopamine_level0.91208890
105MP0009642_abnormal_blood_homeostasis0.91142176
106MP0006292_abnormal_olfactory_placode0.90860713
107MP0001346_abnormal_lacrimal_gland0.90706313
108MP0001849_ear_inflammation0.90645433
109MP0005670_abnormal_white_adipose0.90462325
110MP0002971_abnormal_brown_adipose0.89754877
111MP0005376_homeostasis/metabolism_phenot0.89674529
112MP0002938_white_spotting0.88433579
113MP0005266_abnormal_metabolism0.88318667
114MP0002127_abnormal_cardiovascular_syste0.87383752
115MP0009046_muscle_twitch0.87370422
116MP0009763_increased_sensitivity_to0.86815957
117MP0003638_abnormal_response/metabolism_0.86724634
118MP0000049_abnormal_middle_ear0.86505673
119MP0002210_abnormal_sex_determination0.86031317
120MP0005451_abnormal_body_composition0.85758666
121MP0003385_abnormal_body_wall0.85574160
122MP0003938_abnormal_ear_development0.84748212
123MP0009785_altered_susceptibility_to0.84568733
124MP0009765_abnormal_xenobiotic_induced0.84108228
125MP0003123_paternal_imprinting0.83870430
126MP0000598_abnormal_liver_morphology0.82938991
127MP0003136_yellow_coat_color0.82642796
128MP0003879_abnormal_hair_cell0.82204803
129MP0005174_abnormal_tail_pigmentation0.82083962
130MP0009764_decreased_sensitivity_to0.81365690
131MP0001984_abnormal_olfaction0.81143752
132MP0008995_early_reproductive_senescence0.80778897
133MP0002972_abnormal_cardiac_muscle0.80262519
134MP0003861_abnormal_nervous_system0.80016126
135MP0003635_abnormal_synaptic_transmissio0.79109072
136MP0004043_abnormal_pH_regulation0.79042071
137MP0002078_abnormal_glucose_homeostasis0.78489231
138MP0004130_abnormal_muscle_cell0.78133798
139MP0010630_abnormal_cardiac_muscle0.77988643
140MP0002184_abnormal_innervation0.77338239
141MP0001501_abnormal_sleep_pattern0.77086325
142MP0003646_muscle_fatigue0.76985425
143MP0005620_abnormal_muscle_contractility0.76573438
144MP0001929_abnormal_gametogenesis0.75652643
145MP0005409_darkened_coat_color0.75342946
146MP0002116_abnormal_craniofacial_bone0.74488253
147MP0006276_abnormal_autonomic_nervous0.74476457
148MP0000631_abnormal_neuroendocrine_gland0.74307952
149MP0001486_abnormal_startle_reflex0.73249340
150MP0002752_abnormal_somatic_nervous0.72487734
151MP0002396_abnormal_hematopoietic_system0.71646916
152MP0002572_abnormal_emotion/affect_behav0.69557175
153MP0003633_abnormal_nervous_system0.68865054
154MP0002132_abnormal_respiratory_system0.67755627
155MP0001765_abnormal_ion_homeostasis0.66497497
156MP0001529_abnormal_vocalization0.64998296
157MP0001853_heart_inflammation0.63893549
158* MP0000230_abnormal_systemic_arterial0.62504449
159MP0005448_abnormal_energy_balance0.60887217
160MP0002063_abnormal_learning/memory/cond0.59206971
161MP0005167_abnormal_blood-brain_barrier0.58660982
162MP0004859_abnormal_synaptic_plasticity0.58163502
163MP0003953_abnormal_hormone_level0.57588061
164MP0005551_abnormal_eye_electrophysiolog0.57272863
165MP0005334_abnormal_fat_pad0.55991448
166MP0001835_abnormal_antigen_presentation0.54290816
167MP0002735_abnormal_chemical_nociception0.52845416
168MP0000639_abnormal_adrenal_gland0.52234610
169MP0002067_abnormal_sensory_capabilities0.52155892
170MP0000465_gastrointestinal_hemorrhage0.51348786

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.94688160
2Prolonged partial thromboplastin time (HP:0003645)4.65971092
3Intrahepatic cholestasis (HP:0001406)4.53849028
4Hypobetalipoproteinemia (HP:0003563)4.38525843
5Hyperlipoproteinemia (HP:0010980)4.35920602
6Exercise-induced myalgia (HP:0003738)4.09210952
7Deep venous thrombosis (HP:0002625)4.01672950
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.86612924
9Xanthomatosis (HP:0000991)3.80612517
10Exercise-induced muscle cramps (HP:0003710)3.80302558
11Hepatic necrosis (HP:0002605)3.69765596
12Ketosis (HP:0001946)3.62765456
13Hepatocellular necrosis (HP:0001404)3.59334042
14Muscle fiber inclusion bodies (HP:0100299)3.55570229
15Hyperammonemia (HP:0001987)3.47368526
16Nemaline bodies (HP:0003798)3.46746321
17Cerebral edema (HP:0002181)3.44796640
18Joint hemorrhage (HP:0005261)3.44685956
19Abnormality of fatty-acid metabolism (HP:0004359)3.38869585
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.31634112
21Abnormality of methionine metabolism (HP:0010901)3.31517911
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30292743
23Acute encephalopathy (HP:0006846)3.27086507
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.24252637
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.23036388
26Myoglobinuria (HP:0002913)3.20713818
27Hyperglycinemia (HP:0002154)3.16459354
28Rhabdomyolysis (HP:0003201)3.15703964
29Abnormal mitochondria in muscle tissue (HP:0008316)3.14787575
30Hyperglycinuria (HP:0003108)3.09720031
31Mitochondrial inheritance (HP:0001427)3.06045542
32Abnormality of serine family amino acid metabolism (HP:0010894)3.05096480
33Abnormality of glycine metabolism (HP:0010895)3.05096480
34Abnormality of dicarboxylic acid metabolism (HP:0010995)3.04809592
35Dicarboxylic aciduria (HP:0003215)3.04809592
36Acute necrotizing encephalopathy (HP:0006965)3.04783100
37Bundle branch block (HP:0011710)3.03084040
38Myokymia (HP:0002411)2.99703069
39Myopathic facies (HP:0002058)2.92996282
40Hyperbilirubinemia (HP:0002904)2.91438538
41Delayed CNS myelination (HP:0002188)2.91117846
42Generalized aminoaciduria (HP:0002909)2.88883730
43Increased CSF lactate (HP:0002490)2.88730150
44Hypolipoproteinemia (HP:0010981)2.88455759
45Lethargy (HP:0001254)2.87475339
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.86377069
47Lactic acidosis (HP:0003128)2.85589698
48Metabolic acidosis (HP:0001942)2.85402002
49Hand muscle atrophy (HP:0009130)2.77381923
50Conjugated hyperbilirubinemia (HP:0002908)2.74636908
51Abnormal respiratory motile cilium physiology (HP:0012261)2.72280346
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70356168
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70356168
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.68510909
55Fat malabsorption (HP:0002630)2.67200894
56Abnormality of the intrinsic pathway (HP:0010989)2.66661460
57Hypoglycemic coma (HP:0001325)2.66430692
58Increased intramyocellular lipid droplets (HP:0012240)2.66093580
59Ankle clonus (HP:0011448)2.64540226
60Abnormality of serum amino acid levels (HP:0003112)2.63627177
61Ketoacidosis (HP:0001993)2.62711988
62Type 1 muscle fiber predominance (HP:0003803)2.62694720
63Increased muscle lipid content (HP:0009058)2.61687531
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.58941457
65Renal cortical cysts (HP:0000803)2.58360776
66Complement deficiency (HP:0004431)2.57571334
67Gait imbalance (HP:0002141)2.56999203
68Abnormality of the common coagulation pathway (HP:0010990)2.56345167
69Hyperventilation (HP:0002883)2.54316808
70Reticulocytosis (HP:0001923)2.50887202
71Atelectasis (HP:0100750)2.50721458
72Broad distal phalanx of finger (HP:0009836)2.50417840
73Ragged-red muscle fibers (HP:0003200)2.50226473
74Progressive macrocephaly (HP:0004481)2.49882058
75Abnormality of pyrimidine metabolism (HP:0004353)2.44839625
76Upper limb amyotrophy (HP:0009129)2.44188087
77Distal upper limb amyotrophy (HP:0007149)2.44188087
78Hypercholesterolemia (HP:0003124)2.43280184
79Abnormal hair whorl (HP:0010721)2.42540076
80Abnormal ciliary motility (HP:0012262)2.41974482
81Spontaneous abortion (HP:0005268)2.41897240
82Gout (HP:0001997)2.41180137
83Renal Fanconi syndrome (HP:0001994)2.37742450
84Nephrogenic diabetes insipidus (HP:0009806)2.34984638
85Epidermoid cyst (HP:0200040)2.34919704
86Abnormality of the heme biosynthetic pathway (HP:0010472)2.33449466
87Tubulointerstitial nephritis (HP:0001970)2.32726714
88Rimmed vacuoles (HP:0003805)2.31442536
89Increased serum lactate (HP:0002151)2.30792795
90Vomiting (HP:0002013)2.30518638
91Brushfield spots (HP:0001088)2.29668058
92Congenital primary aphakia (HP:0007707)2.29497645
93Heart block (HP:0012722)2.26876287
94Calcaneovalgus deformity (HP:0001848)2.24613734
95Methylmalonic aciduria (HP:0012120)2.22558646
96Annular pancreas (HP:0001734)2.22243690
97Abnormality of the aortic arch (HP:0012303)2.21786734
98Polyphagia (HP:0002591)2.18690249
99Steatorrhea (HP:0002570)2.17170286
100Lipid accumulation in hepatocytes (HP:0006561)2.16857350
101Abnormality of nucleobase metabolism (HP:0010932)2.16570298
102Menorrhagia (HP:0000132)2.16325967
103Hypoalphalipoproteinemia (HP:0003233)2.14943774
104Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13943329
105Muscle fiber splitting (HP:0003555)2.13362518
1063-Methylglutaconic aciduria (HP:0003535)2.13237935
107Medial flaring of the eyebrow (HP:0010747)2.12238308
108Cholelithiasis (HP:0001081)2.12117671
109EMG: myopathic abnormalities (HP:0003458)2.11557696
110Glycosuria (HP:0003076)2.11464618
111Abnormality of urine glucose concentration (HP:0011016)2.11464618
112Focal motor seizures (HP:0011153)2.11434640
113Abnormal atrioventricular conduction (HP:0005150)2.10738085
114Abnormal respiratory epithelium morphology (HP:0012253)2.09824878
115Abnormal respiratory motile cilium morphology (HP:0005938)2.09824878
116Fair hair (HP:0002286)2.07229452
117Abnormal gallbladder physiology (HP:0012438)2.04700802
118Cholecystitis (HP:0001082)2.04700802
119Centrally nucleated skeletal muscle fibers (HP:0003687)2.04343600
120Abnormality of purine metabolism (HP:0004352)2.02435635
121Gingival bleeding (HP:0000225)2.01770395
122Emotional lability (HP:0000712)2.01059805
123Methylmalonic acidemia (HP:0002912)2.00575367
124Opisthotonus (HP:0002179)2.00272951
125Aplastic anemia (HP:0001915)2.00037876
126Vaginal fistula (HP:0004320)1.98704543
127Diaphragmatic weakness (HP:0009113)1.98030864
128Progressive microcephaly (HP:0000253)1.97591752
129Abnormal eating behavior (HP:0100738)1.97428757
130Muscle stiffness (HP:0003552)1.97235449
131Poor eye contact (HP:0000817)1.96776101
132Acanthocytosis (HP:0001927)1.96523634
133Epistaxis (HP:0000421)1.96498816
134Impaired vibration sensation in the lower limbs (HP:0002166)1.95714645
135Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95638860
136Thyroid-stimulating hormone excess (HP:0002925)1.95618312
137Occipital encephalocele (HP:0002085)1.95525648
138Reduced antithrombin III activity (HP:0001976)1.94725718
139Increased hepatocellular lipid droplets (HP:0006565)1.94601186
140Shoulder girdle muscle weakness (HP:0003547)1.93786648
141Exercise intolerance (HP:0003546)1.91567701
142Prolonged bleeding time (HP:0003010)1.89604154
143Abnormality of the lower motor neuron (HP:0002366)1.89370374
144Epileptic encephalopathy (HP:0200134)1.88586640
145Increased serum pyruvate (HP:0003542)1.87248182
146Abnormality of glycolysis (HP:0004366)1.87248182
147Elevated hepatic transaminases (HP:0002910)1.86967496
148Purpura (HP:0000979)1.86823813
149Late onset (HP:0003584)1.86672826
150Left ventricular hypertrophy (HP:0001712)1.86347886
151Deformed tarsal bones (HP:0008119)1.86084244
152Abnormal gallbladder morphology (HP:0012437)1.85597272
153Spastic gait (HP:0002064)1.85140100
154Spastic paraparesis (HP:0002313)1.84182722
155Increased variability in muscle fiber diameter (HP:0003557)1.84122692
156Poor coordination (HP:0002370)1.83627832
157Respiratory failure (HP:0002878)1.82718711
158Hypoplastic pelvis (HP:0008839)1.81870315
159Impaired platelet aggregation (HP:0003540)1.81655155
160Abnormal platelet function (HP:0011869)1.81655155
161Impaired social interactions (HP:0000735)1.80234732
162Abnormal social behavior (HP:0012433)1.80234732
163Action tremor (HP:0002345)1.80191209
164Subaortic stenosis (HP:0001682)1.80031655
165Abnormality of the left ventricular outflow tract (HP:0011103)1.80031655
166Rectal fistula (HP:0100590)1.79060548
167Rectovaginal fistula (HP:0000143)1.79060548
168Nephronophthisis (HP:0000090)1.76690955
169Delayed myelination (HP:0012448)1.76448390
170Abnormality of skeletal muscle fiber size (HP:0012084)1.76131600
171Myotonia (HP:0002486)1.74581525
172Cerebral palsy (HP:0100021)1.74377178
173EMG: neuropathic changes (HP:0003445)1.73909424
174Febrile seizures (HP:0002373)1.71844309
175Testicular atrophy (HP:0000029)1.69929232
176Abnormality of the calf musculature (HP:0001430)1.69025794
177Broad foot (HP:0001769)1.67301450
178Stridor (HP:0010307)1.65499158
179Turricephaly (HP:0000262)1.64336627
180Growth hormone excess (HP:0000845)1.61148429
181Atrioventricular block (HP:0001678)1.58985728
182Vaginal atresia (HP:0000148)1.58493469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.53278806
2MUSK3.76612727
3MAP3K123.59636898
4STK163.27105766
5CDK193.07620244
6TNIK2.98446925
7FLT32.91129763
8PHKG12.70187877
9PHKG22.70187877
10CASK2.66205492
11KIT2.53013065
12MAP2K72.50264046
13PAK62.25562193
14MARK12.24972655
15EPHA32.16324622
16SIK22.12677179
17PINK12.11902123
18MYLK2.05633477
19PNCK1.96789084
20CCNB11.93784629
21MAP2K41.84823215
22NTRK21.80746354
23ADRBK21.80215238
24TAOK31.77696074
25TEC1.73459954
26MAP4K21.73409187
27BMX1.61944911
28DAPK11.57314256
29UHMK11.48596017
30PDK31.46298247
31PDK41.46298247
32IRAK21.41700743
33TIE11.39146024
34PIK3CG1.38935199
35EPHB21.38908964
36OXSR11.38478788
37BTK1.34167574
38CSF1R1.33330989
39EPHB11.31244199
40FES1.30708252
41INSRR1.26561701
42MAP2K61.23961470
43PRKD31.23701891
44MAP3K41.20257444
45PTK2B1.17506093
46TNK21.14398444
47SIK31.12562560
48CDK51.12522421
49TXK1.11016709
50MARK21.10322784
51NME21.09579664
52KSR21.08729955
53SYK1.05683489
54MAPKAPK51.02424874
55BRAF1.01723974
56TTN1.01673639
57CAMK10.98958070
58DYRK1B0.98808825
59BRSK10.97960399
60MAP3K60.97556354
61WNK30.97327794
62CDK80.97050388
63MAPK40.96475146
64DAPK20.96015447
65CAMKK10.93782864
66PLK20.92734961
67DYRK1A0.91923988
68CAMKK20.90108937
69MAP2K30.88288694
70CDK11A0.87877395
71MATK0.86909276
72MAPK110.86588261
73TRIB30.86355991
74EPHA40.86242970
75ERBB40.85891468
76PIK3CA0.85827277
77MAP4K10.85364755
78BLK0.83810532
79BCR0.82892991
80CAMK2B0.81663200
81TGFBR10.80499486
82RAF10.80143652
83GRK70.79912747
84TESK10.79601239
85KSR10.79051022
86SIK10.78542140
87DYRK20.76585335
88GRK10.76483555
89PKN10.76332303
90MAPK120.74506223
91STK110.74201904
92PRKD20.73979171
93LIMK10.73098993
94PASK0.72541565
95CDK150.72136941
96BMPR1B0.71967939
97HIPK20.71136778
98VRK10.71038494
99MAPK150.69754230
100MAP2K20.69288165
101CDK140.69228084
102ARAF0.69072811
103MAPK100.68816694
104TYRO30.68149009
105CDK180.67908996
106PDK10.67629637
107KDR0.63710041
108IRAK10.63425158
109MAP3K90.62689634
110GRK50.62629728
111LYN0.61615218
112RET0.60915761
113NTRK30.59678022
114SGK20.58025161
115NME10.57787253
116PRKD10.57716672
117MAP3K130.57596681
118GRK60.56858202
119CAMK40.56469929
120TSSK60.56349075
121CSNK1G30.56300481
122YES10.56212390
123MINK10.55226680
124FGFR40.54669985
125CAMK2D0.53688998
126ACVR1B0.53493155
127MOS0.53006776
128CDK30.52975782
129TBK10.52863465
130CAMK2G0.52711231
131PRKG20.51912453
132PDPK10.51164690
133NEK10.51076690
134ROCK10.50709126
135NTRK10.49951024
136PRKAA10.49513686
137MAP3K70.49330739
138PRKCG0.48716068
139RIPK40.48458663
140PRKAA20.47866223
141PIM20.47843946
142PRKCZ0.47625966
143CAMK1G0.47200936
144DMPK0.46602006
145PRPF4B0.45697637
146CAMK2A0.43550597
147PRKACA0.40831924
148SGK4940.39286284
149SGK2230.39286284
150WEE10.39036586
151ADRBK10.37926464
152MKNK20.37768480
153MST1R0.36408994
154CSNK1G10.36221360
155TYK20.35623308
156MAPK130.34440021
157CSNK1G20.34428941
158MAPK70.34127282
159OBSCN0.34085833
160IKBKE0.32190052
161AKT30.32090499
162PRKACG0.31888036
163RPS6KB10.31570734
164PDK20.30846029

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.81099537
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.91331732
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87528861
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.65934850
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52161918
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51076895
7Propanoate metabolism_Homo sapiens_hsa006402.50492577
8Fatty acid degradation_Homo sapiens_hsa000712.43879243
9Peroxisome_Homo sapiens_hsa041462.30056328
10Tryptophan metabolism_Homo sapiens_hsa003802.27204556
11Arginine biosynthesis_Homo sapiens_hsa002202.21498033
12Butanoate metabolism_Homo sapiens_hsa006502.21163603
13Nitrogen metabolism_Homo sapiens_hsa009102.18256733
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06471269
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02238192
16Pyruvate metabolism_Homo sapiens_hsa006202.00277523
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98192468
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98002332
19Fatty acid elongation_Homo sapiens_hsa000621.96804987
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93244411
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88748300
22beta-Alanine metabolism_Homo sapiens_hsa004101.87993348
23Complement and coagulation cascades_Homo sapiens_hsa046101.86228624
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85109474
25Fatty acid metabolism_Homo sapiens_hsa012121.79980008
26Histidine metabolism_Homo sapiens_hsa003401.77567673
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72386343
28Caffeine metabolism_Homo sapiens_hsa002321.70013766
29Chemical carcinogenesis_Homo sapiens_hsa052041.69853168
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.65226515
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.61854894
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61442054
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.56571293
34Oxidative phosphorylation_Homo sapiens_hsa001901.51473366
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50423993
36PPAR signaling pathway_Homo sapiens_hsa033201.50042490
37Retinol metabolism_Homo sapiens_hsa008301.46358686
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43314911
39Sulfur metabolism_Homo sapiens_hsa009201.43251194
40Folate biosynthesis_Homo sapiens_hsa007901.40721803
41Carbon metabolism_Homo sapiens_hsa012001.37399383
42Base excision repair_Homo sapiens_hsa034101.36999838
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32457914
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27413564
45Amphetamine addiction_Homo sapiens_hsa050311.27353452
46Phenylalanine metabolism_Homo sapiens_hsa003601.26197697
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23668066
48Parkinsons disease_Homo sapiens_hsa050121.22764442
49Cocaine addiction_Homo sapiens_hsa050301.22277046
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21529027
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18675717
52Biosynthesis of amino acids_Homo sapiens_hsa012301.17350932
53Sulfur relay system_Homo sapiens_hsa041221.16927296
54Tyrosine metabolism_Homo sapiens_hsa003501.16350438
55ABC transporters_Homo sapiens_hsa020101.14737516
56Insulin secretion_Homo sapiens_hsa049111.14122160
57Bile secretion_Homo sapiens_hsa049761.13172207
58Circadian rhythm_Homo sapiens_hsa047101.10769119
59Selenocompound metabolism_Homo sapiens_hsa004501.10533250
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09270279
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05402637
62Starch and sucrose metabolism_Homo sapiens_hsa005001.05323634
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.01382391
64Vitamin B6 metabolism_Homo sapiens_hsa007500.95026341
65Oocyte meiosis_Homo sapiens_hsa041140.90719610
66Circadian entrainment_Homo sapiens_hsa047130.90376947
67Dopaminergic synapse_Homo sapiens_hsa047280.88679679
68Vitamin digestion and absorption_Homo sapiens_hsa049770.86056239
69Staphylococcus aureus infection_Homo sapiens_hsa051500.85944742
70Arginine and proline metabolism_Homo sapiens_hsa003300.84166534
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84150214
72Alzheimers disease_Homo sapiens_hsa050100.82960610
73Metabolic pathways_Homo sapiens_hsa011000.80568201
74Dilated cardiomyopathy_Homo sapiens_hsa054140.79853141
75AMPK signaling pathway_Homo sapiens_hsa041520.78834175
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.77633355
77Calcium signaling pathway_Homo sapiens_hsa040200.77127432
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75764613
79Glutamatergic synapse_Homo sapiens_hsa047240.75501258
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75107744
81Long-term potentiation_Homo sapiens_hsa047200.74695360
82Steroid biosynthesis_Homo sapiens_hsa001000.72114429
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68608774
84Oxytocin signaling pathway_Homo sapiens_hsa049210.67843582
85Glutathione metabolism_Homo sapiens_hsa004800.65544644
86Huntingtons disease_Homo sapiens_hsa050160.65299337
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65297567
88Insulin signaling pathway_Homo sapiens_hsa049100.65266981
89Pentose phosphate pathway_Homo sapiens_hsa000300.63302643
90Glycerolipid metabolism_Homo sapiens_hsa005610.57394729
91Gastric acid secretion_Homo sapiens_hsa049710.57211938
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56674542
93Fanconi anemia pathway_Homo sapiens_hsa034600.56476619
94Notch signaling pathway_Homo sapiens_hsa043300.56169952
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54284966
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53485142
97Melanogenesis_Homo sapiens_hsa049160.53352557
98Axon guidance_Homo sapiens_hsa043600.53000675
99Fructose and mannose metabolism_Homo sapiens_hsa000510.50741573
100Hedgehog signaling pathway_Homo sapiens_hsa043400.49309345
101Nicotine addiction_Homo sapiens_hsa050330.48664723
102Fat digestion and absorption_Homo sapiens_hsa049750.47700156
103Basal cell carcinoma_Homo sapiens_hsa052170.46554756
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45087171
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40675775
106Galactose metabolism_Homo sapiens_hsa000520.40481137
107cAMP signaling pathway_Homo sapiens_hsa040240.39779298
108Wnt signaling pathway_Homo sapiens_hsa043100.38875440
109Collecting duct acid secretion_Homo sapiens_hsa049660.38697199
110Ribosome_Homo sapiens_hsa030100.37814038
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36650257
112Salivary secretion_Homo sapiens_hsa049700.36144683
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34590182
114Pyrimidine metabolism_Homo sapiens_hsa002400.31824147
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30462027
116GABAergic synapse_Homo sapiens_hsa047270.28302477
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27807262
118Protein export_Homo sapiens_hsa030600.25633600
119Synaptic vesicle cycle_Homo sapiens_hsa047210.24159834
120Fatty acid biosynthesis_Homo sapiens_hsa000610.23317075
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21015471
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18749034
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18488794
124Purine metabolism_Homo sapiens_hsa002300.18364305
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18258897
126One carbon pool by folate_Homo sapiens_hsa006700.17450944
127Glucagon signaling pathway_Homo sapiens_hsa049220.16180778
128Lysine degradation_Homo sapiens_hsa003100.15930510
129Taste transduction_Homo sapiens_hsa047420.14425278
130Cardiac muscle contraction_Homo sapiens_hsa042600.12691180
131Linoleic acid metabolism_Homo sapiens_hsa005910.12405793
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12360245
133Morphine addiction_Homo sapiens_hsa050320.07256495
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.06062349
135Arachidonic acid metabolism_Homo sapiens_hsa005900.05588871
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05054975
137Regulation of autophagy_Homo sapiens_hsa041400.03768265
138Other glycan degradation_Homo sapiens_hsa005110.02487337

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »