SIRPB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.31752006
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.31752006
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.27952661
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.27952661
5modulation by symbiont of host immune response (GO:0052553)6.27952661
6positive regulation by symbiont of host defense response (GO:0052509)6.27952661
7modulation by symbiont of host defense response (GO:0052031)6.27952661
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.27952661
9positive regulation of gamma-delta T cell activation (GO:0046645)6.03258903
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.02489379
11neutrophil activation involved in immune response (GO:0002283)5.66894776
12macrophage activation involved in immune response (GO:0002281)5.26315205
13detection of other organism (GO:0098543)5.22765886
14response to peptidoglycan (GO:0032494)5.14917180
15antigen processing and presentation of endogenous antigen (GO:0019883)5.11384843
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.05132201
17regulation of B cell receptor signaling pathway (GO:0050855)4.89567806
18cellular extravasation (GO:0045123)4.89070437
19detection of bacterium (GO:0016045)4.88581155
20detection of molecule of bacterial origin (GO:0032490)4.77934446
21negative regulation of interleukin-12 production (GO:0032695)4.74600800
22detection of external biotic stimulus (GO:0098581)4.60816858
23microglial cell activation (GO:0001774)4.59670634
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.51385307
25neutrophil activation (GO:0042119)4.50293055
26respiratory burst (GO:0045730)4.45973241
27regulation of interferon-beta biosynthetic process (GO:0045357)4.42812077
28regulation of gamma-delta T cell activation (GO:0046643)4.37331696
29negative regulation of lymphocyte mediated immunity (GO:0002707)4.33107832
30leukocyte aggregation (GO:0070486)4.30977079
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.30476224
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.23175432
33response to host immune response (GO:0052572)4.23175432
34neutrophil mediated immunity (GO:0002446)4.22147810
35leukocyte migration involved in inflammatory response (GO:0002523)4.11855583
36detection of biotic stimulus (GO:0009595)4.10083925
37macrophage activation (GO:0042116)4.09225481
38granulocyte activation (GO:0036230)4.09042927
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.05448573
40immunoglobulin mediated immune response (GO:0016064)4.02779500
41regulation of mast cell degranulation (GO:0043304)3.97837616
42myeloid cell activation involved in immune response (GO:0002275)3.95573747
43negative regulation of T cell mediated immunity (GO:0002710)3.87768461
44positive regulation of mast cell activation (GO:0033005)3.87141053
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.83823126
46response to host (GO:0075136)3.83823126
47response to host defenses (GO:0052200)3.83823126
48negative regulation of leukocyte mediated immunity (GO:0002704)3.81716101
49regulation of gamma-delta T cell differentiation (GO:0045586)3.76533619
50response to interleukin-15 (GO:0070672)3.75929990
51positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.72319882
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.72178470
53regulation of mast cell activation involved in immune response (GO:0033006)3.68321265
54regulation of mast cell activation (GO:0033003)3.60405475
55myeloid leukocyte mediated immunity (GO:0002444)3.58087786
56negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.56912511
57regulation of leukocyte degranulation (GO:0043300)3.52017586
58production of molecular mediator involved in inflammatory response (GO:0002532)3.51872273
59cellular response to interleukin-15 (GO:0071350)3.43865027
60antigen processing and presentation via MHC class Ib (GO:0002475)3.38462369
61positive regulation of mast cell activation involved in immune response (GO:0033008)3.36970806
62positive regulation of mast cell degranulation (GO:0043306)3.36970806
63leukocyte degranulation (GO:0043299)3.36016419
64B cell receptor signaling pathway (GO:0050853)3.35652205
65response to muramyl dipeptide (GO:0032495)3.34960498
66regulation of B cell differentiation (GO:0045577)3.32591341
67regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.28646897
68regulation of tolerance induction (GO:0002643)3.27746633
69positive regulation of B cell differentiation (GO:0045579)3.27218596
70regulation of T cell tolerance induction (GO:0002664)3.20650651
71defense response to protozoan (GO:0042832)3.19930509
72negative regulation of erythrocyte differentiation (GO:0045647)3.19183291
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.18508759
74B cell mediated immunity (GO:0019724)3.17717620
75activated T cell proliferation (GO:0050798)3.13453897
76negative regulation of phagocytosis (GO:0050765)3.12437152
77cellular response to type I interferon (GO:0071357)3.10754418
78type I interferon signaling pathway (GO:0060337)3.10754418
79regulation of regulated secretory pathway (GO:1903305)3.10750338
80response to type I interferon (GO:0034340)3.08715256
81germinal center formation (GO:0002467)3.08651316
82positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.08638655
83negative regulation of interleukin-6 production (GO:0032715)3.07637249
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06893166
85interferon-gamma-mediated signaling pathway (GO:0060333)3.04038269
86myeloid leukocyte activation (GO:0002274)3.02582409
87negative thymic T cell selection (GO:0045060)3.01810756
88dendritic cell migration (GO:0036336)3.00922069
89lipopolysaccharide-mediated signaling pathway (GO:0031663)2.99094173
90positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.98632897
91positive regulation of interferon-alpha production (GO:0032727)2.97482951
92positive thymic T cell selection (GO:0045059)2.96966589
93negative regulation of cytokine production involved in immune response (GO:0002719)2.94711304
94regulation of T cell mediated cytotoxicity (GO:0001914)2.93888800
95positive regulation of cellular amide metabolic process (GO:0034250)2.93656087
96negative T cell selection (GO:0043383)2.92889722
97regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.91990768
98negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.91620779
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91265138
100neutrophil chemotaxis (GO:0030593)2.90921190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.71735570
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.99797180
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.52331807
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.91458852
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.90409482
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.43861350
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.42211929
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.37815675
9* SPI1_23547873_ChIP-Seq_NB4_Human2.92939448
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88747352
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.88077612
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84350442
13VDR_24763502_ChIP-Seq_THP-1_Human2.78916137
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.78773093
15SPI1_23127762_ChIP-Seq_K562_Human2.76479954
16RUNX_20019798_ChIP-Seq_JUKART_Human2.75696455
17VDR_21846776_ChIP-Seq_THP-1_Human2.71599661
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65222562
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53469037
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52206208
21SCL_19346495_ChIP-Seq_HPC-7_Human2.48294877
22MYB_26560356_Chip-Seq_TH2_Human2.34886410
23* MAF_26560356_Chip-Seq_TH1_Human2.25252822
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.22422194
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20036079
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.19164669
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17861633
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.15234139
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13559946
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11308644
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07049474
32UTX_26944678_Chip-Seq_JUKART_Human2.05526131
33VDR_24787735_ChIP-Seq_THP-1_Human2.01336188
34MYB_26560356_Chip-Seq_TH1_Human1.98660709
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93623695
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85416943
37MYC_22102868_ChIP-Seq_BL_Human1.80056414
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.79135001
39TCF7_22412390_ChIP-Seq_EML_Mouse1.75115950
40GATA3_27048872_Chip-Seq_THYMUS_Human1.74553144
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72757262
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.71810438
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.66514307
44MAF_26560356_Chip-Seq_TH2_Human1.64598756
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63355732
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62884727
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62595245
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.57889125
49KDM2B_26808549_Chip-Seq_DND41_Human1.53139712
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50922596
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45110288
52GATA3_26560356_Chip-Seq_TH2_Human1.44201000
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42264470
54PU_27001747_Chip-Seq_BMDM_Mouse1.38479086
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37597662
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37507949
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37171598
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34503203
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34361522
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34224119
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33908845
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31875128
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30406573
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29412774
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28289050
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28104181
67* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26792578
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26385636
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22944345
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22297095
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21818275
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20082801
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19836593
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19640463
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19126251
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18312289
77GATA1_19941826_ChIP-Seq_K562_Human1.17466225
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16910773
79ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15224578
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08957729
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08654708
82BCL6_27268052_Chip-Seq_Bcells_Human1.05057560
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.04477321
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.02748205
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02620191
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.02075395
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98851583
88GATA2_19941826_ChIP-Seq_K562_Human0.97355607
89GATA1_22025678_ChIP-Seq_K562_Human0.95015156
90LXR_22292898_ChIP-Seq_THP-1_Human0.94473691
91BCOR_27268052_Chip-Seq_Bcells_Human0.94169633
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90576463
93* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89556022
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85048463
95* SPI1_20517297_ChIP-Seq_HL60_Human0.84682403
96SMRT_27268052_Chip-Seq_Bcells_Human0.81336407
97NCOR1_26117541_ChIP-Seq_K562_Human0.77610982
98GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77023130
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73085582
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.70064273

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.19367091
2MP0003436_decreased_susceptibility_to4.37292343
3MP0001835_abnormal_antigen_presentation3.80476837
4MP0003303_peritoneal_inflammation3.76216652
5MP0002419_abnormal_innate_immunity3.33996876
6MP0005025_abnormal_response_to2.96150264
7MP0005671_abnormal_response_to2.95725679
8MP0009785_altered_susceptibility_to2.90313245
9MP0001800_abnormal_humoral_immune2.88556481
10MP0006082_CNS_inflammation2.82850289
11MP0005000_abnormal_immune_tolerance2.81604993
12MP0001790_abnormal_immune_system2.81184778
13MP0005387_immune_system_phenotype2.81184778
14MP0000685_abnormal_immune_system2.78111697
15MP0002723_abnormal_immune_serum2.60868553
16MP0002420_abnormal_adaptive_immunity2.55678877
17MP0002452_abnormal_antigen_presenting2.53335701
18MP0001819_abnormal_immune_cell2.53170471
19MP0002148_abnormal_hypersensitivity_rea2.38620129
20MP0003300_gastrointestinal_ulcer2.32605434
21MP0003191_abnormal_cellular_cholesterol2.27895783
22MP0001533_abnormal_skeleton_physiology2.25853555
23MP0005464_abnormal_platelet_physiology2.12240616
24MP0003172_abnormal_lysosome_physiology2.11605515
25MP0008260_abnormal_autophagy2.06526384
26MP0003828_pulmonary_edema2.04589416
27MP0002405_respiratory_system_inflammati2.03119321
28MP0003763_abnormal_thymus_physiology1.88917683
29MP0002132_abnormal_respiratory_system1.88512464
30MP0000716_abnormal_immune_system1.88118013
31MP0002398_abnormal_bone_marrow1.86824163
32MP0009278_abnormal_bone_marrow1.83439942
33MP0001845_abnormal_inflammatory_respons1.77782233
34MP0010155_abnormal_intestine_physiology1.69485680
35MP0009764_decreased_sensitivity_to1.65173157
36MP0000689_abnormal_spleen_morphology1.59704836
37MP0000465_gastrointestinal_hemorrhage1.58257891
38MP0002277_abnormal_respiratory_mucosa1.55804704
39MP0002722_abnormal_immune_system1.55042670
40MP0004947_skin_inflammation1.55025243
41MP0004883_abnormal_blood_vessel1.54824901
42MP0003183_abnormal_peptide_metabolism1.52702074
43MP0003866_abnormal_defecation1.50748322
44MP0008469_abnormal_protein_level1.49612624
45MP0002396_abnormal_hematopoietic_system1.48809372
46MP0002429_abnormal_blood_cell1.47197356
47MP0005058_abnormal_lysosome_morphology1.42481557
48MP0009333_abnormal_splenocyte_physiolog1.40519455
49MP0004381_abnormal_hair_follicle1.38336501
50MP0005310_abnormal_salivary_gland1.37765379
51MP0005397_hematopoietic_system_phenotyp1.35903259
52MP0001545_abnormal_hematopoietic_system1.35903259
53MP0003075_altered_response_to1.32570958
54MP0000703_abnormal_thymus_morphology1.32102382
55MP0005451_abnormal_body_composition1.29691218
56MP0003690_abnormal_glial_cell1.28999634
57MP0000858_altered_metastatic_potential1.27558603
58MP0002998_abnormal_bone_remodeling1.24861895
59MP0001851_eye_inflammation1.24149445
60MP0005164_abnormal_response_to1.21111607
61MP0004510_myositis1.07508508
62MP0000343_altered_response_to1.01960418
63MP0002166_altered_tumor_susceptibility0.97648815
64MP0005166_decreased_susceptibility_to0.96630260
65MP0001986_abnormal_taste_sensitivity0.93275594
66MP0000604_amyloidosis0.91472023
67MP0005075_abnormal_melanosome_morpholog0.90961738
68MP0003806_abnormal_nucleotide_metabolis0.90562260
69MP0001853_heart_inflammation0.90065048
70MP0008004_abnormal_stomach_pH0.89600448
71MP0000015_abnormal_ear_pigmentation0.89284770
72MP0005390_skeleton_phenotype0.89147602
73MP0000569_abnormal_digit_pigmentation0.87722817
74MP0003448_altered_tumor_morphology0.87169004
75MP0009763_increased_sensitivity_to0.87085207
76MP0003656_abnormal_erythrocyte_physiolo0.85682716
77MP0001663_abnormal_digestive_system0.83230307
78MP0004808_abnormal_hematopoietic_stem0.75276138
79MP0009765_abnormal_xenobiotic_induced0.72902639
80MP0004130_abnormal_muscle_cell0.66613197
81MP0003045_fibrosis0.65891614
82MP0008874_decreased_physiological_sensi0.64886825
83MP0003795_abnormal_bone_structure0.64655107
84MP0000249_abnormal_blood_vessel0.64348475
85MP0003221_abnormal_cardiomyocyte_apopto0.62576801
86MP0002933_joint_inflammation0.61781397
87MP0002332_abnormal_exercise_endurance0.61082296
88MP0002928_abnormal_bile_duct0.59420018
89MP0000490_abnormal_crypts_of0.58518018
90MP0005083_abnormal_biliary_tract0.58359653
91MP0005167_abnormal_blood-brain_barrier0.57612766
92MP0005319_abnormal_enzyme/_coenzyme0.56936311
93MP0001873_stomach_inflammation0.54507232
94MP0002006_tumorigenesis0.54231740
95MP0002133_abnormal_respiratory_system0.53909565
96MP0005388_respiratory_system_phenotype0.53909565
97MP0005376_homeostasis/metabolism_phenot0.53222249
98MP0005377_hearing/vestibular/ear_phenot0.52252881
99MP0003878_abnormal_ear_physiology0.52252881
100MP0004484_altered_response_of0.50956919

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.78224218
2Recurrent bacterial skin infections (HP:0005406)6.42529962
3Recurrent abscess formation (HP:0002722)6.42193051
4Myositis (HP:0100614)6.13560834
5Orchitis (HP:0100796)5.78788350
6Abnormality of macrophages (HP:0004311)5.65111786
7Optic neuritis (HP:0100653)5.49417202
8Retrobulbar optic neuritis (HP:0100654)5.49417202
9Recurrent gram-negative bacterial infections (HP:0005420)5.28289215
10Stomatitis (HP:0010280)5.22956960
11Elevated erythrocyte sedimentation rate (HP:0003565)4.90147887
12Recurrent fungal infections (HP:0002841)4.41349874
13Chronic obstructive pulmonary disease (HP:0006510)4.28158304
14Obstructive lung disease (HP:0006536)4.28158304
15Recurrent skin infections (HP:0001581)4.26183107
16Gastrointestinal infarctions (HP:0005244)4.21993749
17Mediastinal lymphadenopathy (HP:0100721)4.21396105
18Meningitis (HP:0001287)4.02699809
19Abnormal delayed hypersensitivity skin test (HP:0002963)4.02204679
20Keratoconjunctivitis sicca (HP:0001097)3.96628821
21Recurrent cutaneous fungal infections (HP:0011370)3.90968072
22Chronic mucocutaneous candidiasis (HP:0002728)3.90968072
23Spontaneous hematomas (HP:0007420)3.86008085
24Encephalitis (HP:0002383)3.83210904
25Hypochromic microcytic anemia (HP:0004840)3.77466836
26Keratoconjunctivitis (HP:0001096)3.69884553
27Gingivitis (HP:0000230)3.61090784
28Urticaria (HP:0001025)3.55264356
29Increased IgE level (HP:0003212)3.54666048
30Vasculitis (HP:0002633)3.43955207
31Prolonged bleeding time (HP:0003010)3.31619262
32Hemoptysis (HP:0002105)3.28851978
33Episodic fever (HP:0001954)3.26432244
34Chest pain (HP:0100749)3.25986603
35Hypochromic anemia (HP:0001931)3.22534160
36Amyloidosis (HP:0011034)3.07115140
37Cellulitis (HP:0100658)3.06011878
38Pulmonary infiltrates (HP:0002113)3.05151165
39T lymphocytopenia (HP:0005403)3.02171528
40Gingival bleeding (HP:0000225)3.00074106
41Leukocytosis (HP:0001974)2.98061453
42Arterial thrombosis (HP:0004420)2.95068532
43Abnormality of T cell number (HP:0011839)2.93726525
44Peritonitis (HP:0002586)2.89978811
45Epistaxis (HP:0000421)2.80039535
46Anorexia (HP:0002039)2.79701012
47Pulmonary embolism (HP:0002204)2.77127999
48Recurrent viral infections (HP:0004429)2.72925539
49Pustule (HP:0200039)2.69303673
50Inflammation of the large intestine (HP:0002037)2.63341999
51Abnormality of T cells (HP:0002843)2.60208154
52Panhypogammaglobulinemia (HP:0003139)2.58198879
53Petechiae (HP:0000967)2.56339310
54Increased cerebral lipofuscin (HP:0011813)2.55612016
55Granulocytopenia (HP:0001913)2.53613311
56Osteomyelitis (HP:0002754)2.53406494
57Gastrointestinal inflammation (HP:0004386)2.48982980
58Gangrene (HP:0100758)2.44657015
59Microcytic anemia (HP:0001935)2.44243933
60Abnormality of glycolipid metabolism (HP:0010969)2.44178751
61Abnormality of liposaccharide metabolism (HP:0010968)2.44178751
62Abnormality of glycosphingolipid metabolism (HP:0004343)2.44178751
63Increased IgM level (HP:0003496)2.43357033
64Abnormality of the pleura (HP:0002103)2.40847509
65Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35900206
66Sepsis (HP:0100806)2.32186227
67Abnormality of the endocardium (HP:0004306)2.22205158
68Abnormality of T cell physiology (HP:0011840)2.20298243
69Hypergammaglobulinemia (HP:0010702)2.17547241
70Vertigo (HP:0002321)2.17485078
71Abnormality of the peritoneum (HP:0002585)2.17146792
72Eosinophilia (HP:0001880)2.16715520
73Loss of speech (HP:0002371)2.16270851
74Glomerulopathy (HP:0100820)2.14212336
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.12852656
76Lymphopenia (HP:0001888)2.09114672
77Purpura (HP:0000979)2.08735578
78Increased serum ferritin (HP:0003281)2.06800932
79Keratitis (HP:0000491)2.06453351
80Hepatosplenomegaly (HP:0001433)2.05052954
81Abnormality of iron homeostasis (HP:0011031)2.04385230
82Acne (HP:0001061)2.04330236
83Colitis (HP:0002583)2.03403911
84Skin ulcer (HP:0200042)2.02835020
85Cheilitis (HP:0100825)2.02483406
86Polyneuropathy (HP:0001271)2.00919115
87Autoimmune thrombocytopenia (HP:0001973)1.98310867
88Abnormality of the pericardium (HP:0001697)1.96880101
89Abnormality of cells of the lymphoid lineage (HP:0012140)1.94951680
90Premature loss of primary teeth (HP:0006323)1.94000374
91Acute hepatic failure (HP:0006554)1.92230153
92Viral hepatitis (HP:0006562)1.91722903
93Agammaglobulinemia (HP:0004432)1.88618910
94Abnormal platelet volume (HP:0011876)1.88216465
95Slow saccadic eye movements (HP:0000514)1.87990434
96Hematochezia (HP:0002573)1.85240666
97Skin rash (HP:0000988)1.84955902
98Recurrent pneumonia (HP:0006532)1.82883063
99Amaurosis fugax (HP:0100576)1.82857976
100Abnormality of eosinophils (HP:0001879)1.82023981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.14861858
2BLK3.56084207
3MAP4K13.32816966
4IRAK43.18649398
5MAP2K33.10183956
6TYK22.82459580
7FES2.78673577
8CSK2.78224573
9ERN12.59082090
10TNK22.45186065
11GRK62.18555474
12ZAP702.12704230
13EPHB11.94837587
14FGR1.90139106
15BTK1.88785557
16TXK1.87540119
17PRPF4B1.86480671
18MAP3K31.82836772
19MAP3K111.82826679
20HCK1.80088708
21SYK1.79588552
22JAK31.74309087
23TAOK11.72388157
24TAOK31.70194020
25MAP3K141.56103992
26IKBKE1.50901097
27LYN1.49189774
28JAK21.47447145
29CSF1R1.39198386
30MAP3K131.34974465
31YES11.32182816
32TBK11.24612145
33KIT1.24067093
34KSR21.23036993
35JAK11.23009996
36LCK1.20557868
37MAP3K11.19121305
38ITK1.13773772
39TEC1.13720529
40SIK31.12750227
41IRAK11.07520422
42MARK21.05511478
43TGFBR21.03913231
44MATK1.00268372
45MARK30.97356253
46IRAK20.94763090
47TAOK20.92501024
48BMPR20.90485019
49PDK10.90109184
50STK100.89428549
51CDK190.87623996
52IKBKB0.86201531
53MAP3K60.82964202
54PTK60.81146650
55PRKD20.78939852
56SIK20.76555487
57PDPK10.75021831
58PIK3CG0.71498908
59MAP3K20.71140583
60LRRK20.70890521
61MAP3K70.70105787
62PTK2B0.69826061
63FYN0.68039617
64MAP2K40.67577822
65MAP3K50.65621886
66GRK70.65588255
67TESK20.63934827
68MAP2K60.61320454
69PRKCQ0.61222641
70STK110.60144925
71MAPK120.59126269
72DAPK20.59001776
73DYRK1B0.58565408
74EPHA30.58092294
75SGK30.56733387
76CDC42BPA0.54979442
77MAPK70.53259921
78HIPK20.49368757
79TRIB30.46783052
80RAF10.46286727
81KSR10.44702431
82SGK20.43288804
83PIM10.42330170
84RPS6KL10.41520962
85RPS6KC10.41520962
86FGFR30.40074932
87NLK0.39757010
88RET0.39346407
89CAMKK20.38459596
90RPS6KA60.38355294
91STK380.36895890
92MAPKAPK20.35475838
93PRKCZ0.31771820
94PRKG20.29802360
95CAMKK10.28945730
96ABL10.28160852
97PRKCD0.27907838
98WNK10.26212224
99MOS0.25364978
100DYRK30.24698648

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.17360092
2Leishmaniasis_Homo sapiens_hsa051403.14954313
3Staphylococcus aureus infection_Homo sapiens_hsa051502.99126274
4Graft-versus-host disease_Homo sapiens_hsa053322.31563844
5Tuberculosis_Homo sapiens_hsa051522.30906342
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.29232343
7Allograft rejection_Homo sapiens_hsa053302.24623573
8B cell receptor signaling pathway_Homo sapiens_hsa046622.21013958
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.15246678
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09367742
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.08624045
12Autoimmune thyroid disease_Homo sapiens_hsa053202.07438418
13Malaria_Homo sapiens_hsa051442.00414708
14Primary immunodeficiency_Homo sapiens_hsa053401.95850876
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85774581
16Chemokine signaling pathway_Homo sapiens_hsa040621.74316008
17Hematopoietic cell lineage_Homo sapiens_hsa046401.73728575
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.72470789
19Measles_Homo sapiens_hsa051621.70521754
20Legionellosis_Homo sapiens_hsa051341.69409376
21Type I diabetes mellitus_Homo sapiens_hsa049401.65231273
22Antigen processing and presentation_Homo sapiens_hsa046121.63799945
23Acute myeloid leukemia_Homo sapiens_hsa052211.61544086
24T cell receptor signaling pathway_Homo sapiens_hsa046601.59470591
25Phagosome_Homo sapiens_hsa041451.57003934
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.56866814
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53555863
28Toxoplasmosis_Homo sapiens_hsa051451.53371584
29Influenza A_Homo sapiens_hsa051641.43871705
30Other glycan degradation_Homo sapiens_hsa005111.43521180
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38640444
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38419927
33Viral myocarditis_Homo sapiens_hsa054161.36968651
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.32811146
35African trypanosomiasis_Homo sapiens_hsa051431.32554814
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.31808035
37Asthma_Homo sapiens_hsa053101.29205128
38TNF signaling pathway_Homo sapiens_hsa046681.27191979
39Platelet activation_Homo sapiens_hsa046111.24671507
40Herpes simplex infection_Homo sapiens_hsa051681.22845008
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.21179472
42Pertussis_Homo sapiens_hsa051331.16914187
43Rheumatoid arthritis_Homo sapiens_hsa053231.13016987
44Non-small cell lung cancer_Homo sapiens_hsa052231.12961928
45Hepatitis B_Homo sapiens_hsa051611.07464141
46Salmonella infection_Homo sapiens_hsa051321.04749508
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01873373
48Lysosome_Homo sapiens_hsa041421.01132303
49Hepatitis C_Homo sapiens_hsa051600.97208020
50Shigellosis_Homo sapiens_hsa051310.95191496
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90751227
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87256069
53Pancreatic cancer_Homo sapiens_hsa052120.86785488
54VEGF signaling pathway_Homo sapiens_hsa043700.86264972
55Apoptosis_Homo sapiens_hsa042100.85160920
56Chronic myeloid leukemia_Homo sapiens_hsa052200.81478834
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79306262
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79250100
59Prolactin signaling pathway_Homo sapiens_hsa049170.77972372
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76552739
61Endocytosis_Homo sapiens_hsa041440.76473786
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75360608
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.75084015
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.74928674
65Renal cell carcinoma_Homo sapiens_hsa052110.74523954
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.72805820
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71618057
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.70103652
69FoxO signaling pathway_Homo sapiens_hsa040680.66100980
70Dorso-ventral axis formation_Homo sapiens_hsa043200.65890625
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63057441
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63040636
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62484241
74GnRH signaling pathway_Homo sapiens_hsa049120.62444687
75Amoebiasis_Homo sapiens_hsa051460.62115246
76Regulation of autophagy_Homo sapiens_hsa041400.60896905
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.59729624
78Notch signaling pathway_Homo sapiens_hsa043300.59183009
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59006807
80Choline metabolism in cancer_Homo sapiens_hsa052310.56885532
81Epstein-Barr virus infection_Homo sapiens_hsa051690.56871603
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56471818
83Endometrial cancer_Homo sapiens_hsa052130.52688278
84HIF-1 signaling pathway_Homo sapiens_hsa040660.51298490
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50750905
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49829087
87Viral carcinogenesis_Homo sapiens_hsa052030.47979606
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.45940237
89MAPK signaling pathway_Homo sapiens_hsa040100.44986900
90Rap1 signaling pathway_Homo sapiens_hsa040150.44239150
91mTOR signaling pathway_Homo sapiens_hsa041500.43834023
92Collecting duct acid secretion_Homo sapiens_hsa049660.43767398
93Insulin resistance_Homo sapiens_hsa049310.43227845
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43006492
95Type II diabetes mellitus_Homo sapiens_hsa049300.42832085
96Inositol phosphate metabolism_Homo sapiens_hsa005620.42706992
97Colorectal cancer_Homo sapiens_hsa052100.41474936
98HTLV-I infection_Homo sapiens_hsa051660.40648030
99Estrogen signaling pathway_Homo sapiens_hsa049150.36570830
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35778444

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