SIRPB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.17479014
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.17479014
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.17479014
4modulation by symbiont of host immune response (GO:0052553)6.17479014
5positive regulation by symbiont of host defense response (GO:0052509)6.17479014
6modulation by symbiont of host defense response (GO:0052031)6.17479014
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.12717523
8negative regulation of cell killing (GO:0031342)6.12717523
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.07225323
10positive regulation of gamma-delta T cell activation (GO:0046645)5.88656257
11neutrophil activation involved in immune response (GO:0002283)5.78162135
12detection of other organism (GO:0098543)5.31313141
13macrophage activation involved in immune response (GO:0002281)5.19964490
14response to peptidoglycan (GO:0032494)5.12567980
15cellular extravasation (GO:0045123)5.03312274
16antigen processing and presentation of endogenous antigen (GO:0019883)5.02622848
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.00533311
18detection of bacterium (GO:0016045)4.99264395
19regulation of B cell receptor signaling pathway (GO:0050855)4.98452419
20detection of molecule of bacterial origin (GO:0032490)4.79870294
21leukocyte aggregation (GO:0070486)4.72444696
22detection of external biotic stimulus (GO:0098581)4.67729863
23neutrophil activation (GO:0042119)4.64901078
24negative regulation of interleukin-12 production (GO:0032695)4.52276467
25leukocyte migration involved in inflammatory response (GO:0002523)4.50450321
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.47442330
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.41254622
28respiratory burst (GO:0045730)4.38203587
29regulation of interferon-beta biosynthetic process (GO:0045357)4.34436356
30microglial cell activation (GO:0001774)4.30243448
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.29911338
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.28241726
33response to host immune response (GO:0052572)4.28241726
34regulation of gamma-delta T cell activation (GO:0046643)4.25306646
35granulocyte activation (GO:0036230)4.21419087
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.19862118
37detection of biotic stimulus (GO:0009595)4.12536814
38immunoglobulin mediated immune response (GO:0016064)4.08755039
39neutrophil mediated immunity (GO:0002446)4.03827765
40response to interleukin-15 (GO:0070672)3.97620882
41macrophage activation (GO:0042116)3.94168320
42myeloid cell activation involved in immune response (GO:0002275)3.93872454
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.91067679
44response to host (GO:0075136)3.91067679
45response to host defenses (GO:0052200)3.91067679
46regulation of mast cell degranulation (GO:0043304)3.88902208
47negative regulation of leukocyte mediated immunity (GO:0002704)3.77743920
48positive regulation of mast cell activation (GO:0033005)3.77126165
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.72319985
50regulation of gamma-delta T cell differentiation (GO:0045586)3.69943043
51production of molecular mediator involved in inflammatory response (GO:0002532)3.68955245
52cellular response to interleukin-15 (GO:0071350)3.68808738
53negative regulation of T cell mediated immunity (GO:0002710)3.64578536
54regulation of mast cell activation involved in immune response (GO:0033006)3.62279581
55positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.60024002
56regulation of myeloid leukocyte mediated immunity (GO:0002886)3.59577605
57regulation of mast cell activation (GO:0033003)3.50237594
58myeloid leukocyte mediated immunity (GO:0002444)3.44642492
59antigen processing and presentation via MHC class Ib (GO:0002475)3.42649145
60regulation of leukocyte degranulation (GO:0043300)3.41308530
61leukocyte degranulation (GO:0043299)3.37066399
62B cell receptor signaling pathway (GO:0050853)3.36003983
63regulation of tolerance induction (GO:0002643)3.32311057
64regulation of B cell differentiation (GO:0045577)3.29774962
65regulation of T cell tolerance induction (GO:0002664)3.29416773
66positive regulation of mast cell activation involved in immune response (GO:0033008)3.27288026
67positive regulation of mast cell degranulation (GO:0043306)3.27288026
68type I interferon signaling pathway (GO:0060337)3.27106142
69cellular response to type I interferon (GO:0071357)3.27106142
70response to type I interferon (GO:0034340)3.24345766
71positive regulation of B cell differentiation (GO:0045579)3.23043204
72B cell mediated immunity (GO:0019724)3.22714742
73defense response to protozoan (GO:0042832)3.22208500
74response to muramyl dipeptide (GO:0032495)3.19338773
75regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.17721226
76negative regulation of phagocytosis (GO:0050765)3.15887697
77dendritic cell migration (GO:0036336)3.14674465
78germinal center formation (GO:0002467)3.14626860
79regulation of T-helper 2 cell differentiation (GO:0045628)3.12336797
80negative regulation of T-helper cell differentiation (GO:0045623)3.10250296
81negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10250296
82lipopolysaccharide-mediated signaling pathway (GO:0031663)3.09290704
83negative regulation of interleukin-6 production (GO:0032715)3.08364331
84neutrophil chemotaxis (GO:0030593)3.05492208
85regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05431177
86interferon-gamma-mediated signaling pathway (GO:0060333)3.05363058
87dendritic cell chemotaxis (GO:0002407)3.04642267
88regulation of regulated secretory pathway (GO:1903305)3.04281909
89negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.04101838
90regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.02333506
91positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.01428487
92myeloid leukocyte activation (GO:0002274)3.01353113
93activated T cell proliferation (GO:0050798)2.99479744
94neutrophil migration (GO:1990266)2.97785823
95negative regulation of type 2 immune response (GO:0002829)2.96496447
96negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.92295376
97positive regulation of interferon-alpha production (GO:0032727)2.91581963
98negative regulation of cytokine production involved in immune response (GO:0002719)2.89857919
99negative thymic T cell selection (GO:0045060)2.89843832
100regulation of alpha-beta T cell proliferation (GO:0046640)2.88565556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.55162645
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.90599574
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.53488998
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.01867896
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.88387250
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58988754
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.39646604
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.38767696
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.97090829
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95955351
11* SPI1_23547873_ChIP-Seq_NB4_Human2.90713624
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89054754
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83898169
14VDR_24763502_ChIP-Seq_THP-1_Human2.74825417
15RUNX_20019798_ChIP-Seq_JUKART_Human2.74741232
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73914395
17SPI1_23127762_ChIP-Seq_K562_Human2.73415995
18VDR_21846776_ChIP-Seq_THP-1_Human2.66365839
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60576071
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.55927161
21MYB_26560356_Chip-Seq_TH2_Human2.41537430
22SCL_19346495_ChIP-Seq_HPC-7_Human2.38796070
23MAF_26560356_Chip-Seq_TH1_Human2.30849513
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.27738045
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23144666
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21763674
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.17483910
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15506222
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13918838
30UTX_26944678_Chip-Seq_JUKART_Human2.12329229
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12235719
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05886516
33MYB_26560356_Chip-Seq_TH1_Human2.02575081
34VDR_24787735_ChIP-Seq_THP-1_Human1.99269800
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.92209482
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91097629
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.82564536
38MYC_22102868_ChIP-Seq_BL_Human1.82094684
39TCF7_22412390_ChIP-Seq_EML_Mouse1.75946667
40GATA3_27048872_Chip-Seq_THYMUS_Human1.75216479
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71628661
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.71587879
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67794396
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66954879
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61914402
46* MAF_26560356_Chip-Seq_TH2_Human1.61039444
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58705261
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.55045365
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51272763
50KDM2B_26808549_Chip-Seq_DND41_Human1.50182278
51GATA3_26560356_Chip-Seq_TH2_Human1.45318825
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44724689
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43446293
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42898934
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42770696
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38053898
57PU_27001747_Chip-Seq_BMDM_Mouse1.36641151
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36258185
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35959927
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35378476
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34930348
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34752148
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33395403
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32797572
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30366735
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28654636
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27110276
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26407856
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24596869
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23724036
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23377225
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22892055
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18450418
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17422839
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17147998
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14164355
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13353625
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13345967
79ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11022061
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.11015807
81GATA1_19941826_ChIP-Seq_K562_Human1.08690984
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06695343
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.05256312
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02464073
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.01090944
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00866957
87GATA1_22025678_ChIP-Seq_K562_Human1.00857759
88BCL6_27268052_Chip-Seq_Bcells_Human0.99236406
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93732285
90LXR_22292898_ChIP-Seq_THP-1_Human0.92709956
91GATA2_19941826_ChIP-Seq_K562_Human0.92397724
92BCOR_27268052_Chip-Seq_Bcells_Human0.90015242
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89587317
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89212437
95SPI1_20517297_ChIP-Seq_HL60_Human0.86998550
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86172854
97SMRT_27268052_Chip-Seq_Bcells_Human0.78938028
98GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78728357
99NCOR1_26117541_ChIP-Seq_K562_Human0.76359866
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73742880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.27178664
2MP0003436_decreased_susceptibility_to4.26828668
3MP0003303_peritoneal_inflammation3.90001244
4MP0001835_abnormal_antigen_presentation3.89031652
5MP0002419_abnormal_innate_immunity3.31612504
6MP0005671_abnormal_response_to3.06240520
7MP0009785_altered_susceptibility_to3.00386543
8MP0005025_abnormal_response_to2.99242577
9MP0001800_abnormal_humoral_immune2.90607461
10MP0005000_abnormal_immune_tolerance2.85453257
11MP0006082_CNS_inflammation2.76297679
12MP0001790_abnormal_immune_system2.76072357
13MP0005387_immune_system_phenotype2.76072357
14MP0000685_abnormal_immune_system2.72934809
15MP0002723_abnormal_immune_serum2.64352199
16MP0002420_abnormal_adaptive_immunity2.57287785
17MP0002452_abnormal_antigen_presenting2.54327176
18MP0001819_abnormal_immune_cell2.54152514
19MP0002148_abnormal_hypersensitivity_rea2.39493738
20MP0003191_abnormal_cellular_cholesterol2.36021566
21MP0003300_gastrointestinal_ulcer2.31642159
22MP0001533_abnormal_skeleton_physiology2.19516440
23MP0005464_abnormal_platelet_physiology2.15940386
24MP0002405_respiratory_system_inflammati2.06274194
25MP0003763_abnormal_thymus_physiology1.96458840
26MP0003828_pulmonary_edema1.93027376
27MP0002398_abnormal_bone_marrow1.91334247
28MP0008260_abnormal_autophagy1.91266141
29MP0000716_abnormal_immune_system1.89353961
30MP0002132_abnormal_respiratory_system1.87251208
31MP0003172_abnormal_lysosome_physiology1.87034608
32MP0001845_abnormal_inflammatory_respons1.79666458
33MP0010155_abnormal_intestine_physiology1.74743580
34MP0009278_abnormal_bone_marrow1.72315184
35MP0005451_abnormal_body_composition1.63441760
36MP0009764_decreased_sensitivity_to1.61910748
37MP0004947_skin_inflammation1.60488294
38MP0000689_abnormal_spleen_morphology1.59362259
39MP0002722_abnormal_immune_system1.58080550
40MP0000465_gastrointestinal_hemorrhage1.58050066
41MP0003866_abnormal_defecation1.55944731
42MP0003183_abnormal_peptide_metabolism1.53123053
43MP0002396_abnormal_hematopoietic_system1.51955726
44MP0004883_abnormal_blood_vessel1.51461393
45MP0002277_abnormal_respiratory_mucosa1.49377580
46MP0009333_abnormal_splenocyte_physiolog1.49296869
47MP0002429_abnormal_blood_cell1.48883176
48MP0008469_abnormal_protein_level1.47745507
49MP0004381_abnormal_hair_follicle1.42058447
50MP0000703_abnormal_thymus_morphology1.39125411
51MP0003075_altered_response_to1.36642247
52MP0005310_abnormal_salivary_gland1.33772952
53MP0005397_hematopoietic_system_phenotyp1.33755441
54MP0001545_abnormal_hematopoietic_system1.33755441
55MP0000858_altered_metastatic_potential1.32020002
56MP0001851_eye_inflammation1.27280597
57MP0002998_abnormal_bone_remodeling1.22974792
58MP0005164_abnormal_response_to1.20628039
59MP0004510_myositis1.17722018
60MP0003690_abnormal_glial_cell1.14186228
61MP0005058_abnormal_lysosome_morphology1.13083258
62MP0002166_altered_tumor_susceptibility1.06852724
63MP0005166_decreased_susceptibility_to1.02164317
64MP0000343_altered_response_to0.94596348
65MP0008004_abnormal_stomach_pH0.94229783
66MP0003448_altered_tumor_morphology0.93993879
67MP0003045_fibrosis0.92166322
68MP0009763_increased_sensitivity_to0.88015376
69MP0001853_heart_inflammation0.87146436
70MP0005390_skeleton_phenotype0.87083432
71MP0005075_abnormal_melanosome_morpholog0.85358966
72MP0003656_abnormal_erythrocyte_physiolo0.83971025
73MP0003806_abnormal_nucleotide_metabolis0.83677797
74MP0000015_abnormal_ear_pigmentation0.81836413
75MP0000604_amyloidosis0.81227865
76MP0001663_abnormal_digestive_system0.80895359
77MP0004808_abnormal_hematopoietic_stem0.78702174
78MP0000569_abnormal_digit_pigmentation0.76147875
79MP0001986_abnormal_taste_sensitivity0.72222341
80MP0000490_abnormal_crypts_of0.68896868
81MP0004130_abnormal_muscle_cell0.67874874
82MP0009765_abnormal_xenobiotic_induced0.66945967
83MP0002006_tumorigenesis0.64326330
84MP0003795_abnormal_bone_structure0.63983513
85MP0000249_abnormal_blood_vessel0.63525916
86MP0001873_stomach_inflammation0.62250368
87MP0008874_decreased_physiological_sensi0.61220927
88MP0002332_abnormal_exercise_endurance0.60254314
89MP0002933_joint_inflammation0.59240723
90MP0003221_abnormal_cardiomyocyte_apopto0.57781070
91MP0005083_abnormal_biliary_tract0.56383780
92MP0003878_abnormal_ear_physiology0.55546362
93MP0005377_hearing/vestibular/ear_phenot0.55546362
94MP0002138_abnormal_hepatobiliary_system0.55401027
95MP0005319_abnormal_enzyme/_coenzyme0.54524311
96MP0005388_respiratory_system_phenotype0.51593611
97MP0002133_abnormal_respiratory_system0.51593611
98MP0002928_abnormal_bile_duct0.48815784
99MP0005376_homeostasis/metabolism_phenot0.48502143
100MP0004484_altered_response_of0.47981463

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.83236291
2Recurrent abscess formation (HP:0002722)6.39332212
3Recurrent bacterial skin infections (HP:0005406)6.31232020
4Myositis (HP:0100614)6.01804523
5Abnormality of macrophages (HP:0004311)5.67415484
6Orchitis (HP:0100796)5.66403016
7Optic neuritis (HP:0100653)5.37516489
8Retrobulbar optic neuritis (HP:0100654)5.37516489
9Stomatitis (HP:0010280)5.33778330
10Recurrent gram-negative bacterial infections (HP:0005420)5.25691260
11Elevated erythrocyte sedimentation rate (HP:0003565)4.93478024
12Recurrent fungal infections (HP:0002841)4.34303913
13Chronic obstructive pulmonary disease (HP:0006510)4.31638121
14Obstructive lung disease (HP:0006536)4.31638121
15Gastrointestinal infarctions (HP:0005244)4.28727413
16Recurrent skin infections (HP:0001581)4.19270194
17Mediastinal lymphadenopathy (HP:0100721)4.18354931
18Abnormal delayed hypersensitivity skin test (HP:0002963)4.10682690
19Meningitis (HP:0001287)4.05032326
20Keratoconjunctivitis sicca (HP:0001097)3.96308154
21Hypochromic microcytic anemia (HP:0004840)3.87397162
22Encephalitis (HP:0002383)3.82799540
23Recurrent cutaneous fungal infections (HP:0011370)3.82716452
24Chronic mucocutaneous candidiasis (HP:0002728)3.82716452
25Spontaneous hematomas (HP:0007420)3.71854804
26Keratoconjunctivitis (HP:0001096)3.67904868
27Urticaria (HP:0001025)3.60948168
28Gingivitis (HP:0000230)3.60440479
29Vasculitis (HP:0002633)3.52873483
30Increased IgE level (HP:0003212)3.48138682
31Prolonged bleeding time (HP:0003010)3.45725621
32Chest pain (HP:0100749)3.34576702
33Episodic fever (HP:0001954)3.32073522
34Hypochromic anemia (HP:0001931)3.30906642
35Hemoptysis (HP:0002105)3.16611711
36Gingival bleeding (HP:0000225)3.16519095
37T lymphocytopenia (HP:0005403)3.13348585
38Abnormality of T cell number (HP:0011839)3.03960922
39Pulmonary infiltrates (HP:0002113)3.03938820
40Peritonitis (HP:0002586)2.99179246
41Cellulitis (HP:0100658)2.99139017
42Amyloidosis (HP:0011034)2.98594129
43Arterial thrombosis (HP:0004420)2.96283568
44Leukocytosis (HP:0001974)2.96093023
45Epistaxis (HP:0000421)2.88618178
46Anorexia (HP:0002039)2.85689991
47Pulmonary embolism (HP:0002204)2.75886668
48Recurrent viral infections (HP:0004429)2.73030315
49Petechiae (HP:0000967)2.72654072
50Abnormality of T cells (HP:0002843)2.66699431
51Pustule (HP:0200039)2.66689879
52Inflammation of the large intestine (HP:0002037)2.66004031
53Increased IgM level (HP:0003496)2.58727384
54Gastrointestinal inflammation (HP:0004386)2.53583568
55Granulocytopenia (HP:0001913)2.52232806
56Osteomyelitis (HP:0002754)2.48824190
57Gangrene (HP:0100758)2.48367744
58Microcytic anemia (HP:0001935)2.47013217
59Panhypogammaglobulinemia (HP:0003139)2.43500070
60Abnormality of the pleura (HP:0002103)2.41823473
61Increased cerebral lipofuscin (HP:0011813)2.37691101
62Sepsis (HP:0100806)2.33870593
63Abnormality of T cell physiology (HP:0011840)2.28353262
64Purpura (HP:0000979)2.27197579
65Abnormality of the peritoneum (HP:0002585)2.26695128
66Lymphopenia (HP:0001888)2.25234850
67Hypergammaglobulinemia (HP:0010702)2.23698912
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21177438
69Abnormality of the endocardium (HP:0004306)2.16932986
70Eosinophilia (HP:0001880)2.15365780
71Abnormal platelet volume (HP:0011876)2.15050951
72Glomerulopathy (HP:0100820)2.12318422
73Vertigo (HP:0002321)2.12165852
74Abnormality of liposaccharide metabolism (HP:0010968)2.11530074
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.11530074
76Abnormality of glycolipid metabolism (HP:0010969)2.11530074
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.11264719
78Keratitis (HP:0000491)2.08365188
79Hepatosplenomegaly (HP:0001433)2.04608497
80Skin ulcer (HP:0200042)2.04148243
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.02148001
82Acne (HP:0001061)2.01930946
83Abnormality of the pericardium (HP:0001697)2.00474195
84Increased serum ferritin (HP:0003281)1.99950342
85Acute hepatic failure (HP:0006554)1.99092880
86Colitis (HP:0002583)1.98280035
87Loss of speech (HP:0002371)1.96556773
88Abnormality of iron homeostasis (HP:0011031)1.95467581
89Premature loss of primary teeth (HP:0006323)1.94863805
90Slow saccadic eye movements (HP:0000514)1.92602121
91Autoimmune thrombocytopenia (HP:0001973)1.88712026
92Autoimmune hemolytic anemia (HP:0001890)1.88486842
93Polyneuropathy (HP:0001271)1.88234790
94Recurrent pneumonia (HP:0006532)1.87630979
95Abnormality of the heme biosynthetic pathway (HP:0010472)1.86665284
96Viral hepatitis (HP:0006562)1.86161511
97Skin rash (HP:0000988)1.86041561
98Cheilitis (HP:0100825)1.82753647
99Thrombophlebitis (HP:0004418)1.82221210
100Chronic otitis media (HP:0000389)1.81148585

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.24725159
2MAP4K13.47478124
3BLK3.39574111
4IRAK43.26796601
5MAP2K33.14078679
6TYK22.86144703
7CSK2.81309437
8FES2.63214333
9ERN12.58683634
10TNK22.34703603
11GRK62.31258924
12ZAP702.21289835
13EPHB12.15299380
14TXK2.03392306
15BTK1.87592796
16TAOK11.84433062
17MAP3K31.83964889
18PRPF4B1.83568023
19HCK1.77669466
20SYK1.76777397
21JAK31.76445307
22FGR1.76042497
23MAP3K111.62958489
24MAP3K141.55663919
25JAK21.50696001
26IKBKE1.47103891
27LYN1.46045759
28TAOK31.43141576
29SIK31.35029932
30KSR21.31718852
31YES11.30365491
32MAP3K11.29703465
33JAK11.29533637
34CSF1R1.29492117
35MAP3K131.26636961
36TBK11.24694895
37LCK1.19968972
38KIT1.16765856
39IRAK11.10239742
40ITK1.07912536
41MARK31.06334758
42TEC1.06265015
43MATK1.01669241
44STK100.98672233
45MARK20.97642649
46IRAK20.95926381
47BMPR20.94500588
48PIK3CG0.92524516
49CDK190.92190812
50PDK10.91680775
51MAP3K60.91149948
52PRKD20.84361706
53IKBKB0.83342130
54SIK20.82588221
55TESK20.82366854
56MAP3K20.81102794
57PTK60.80683076
58TGFBR20.79903424
59MAP2K40.78132010
60PTK2B0.76709076
61PDPK10.76085873
62TAOK20.74730503
63FYN0.69409137
64LRRK20.66488840
65MAP3K50.64879918
66MAP3K70.64823946
67GRK70.64004044
68MAPK120.63739110
69STK110.60335694
70MAPK70.57191390
71EPHA30.57045597
72SGK30.56726105
73PRKCQ0.56102528
74DAPK20.49976500
75RAF10.48274766
76FGFR30.46842525
77HIPK20.46467487
78DYRK1B0.46382748
79MAP2K60.45923374
80SMG10.44793319
81TRIB30.43911681
82PIM10.43470913
83KSR10.42376620
84CDC42BPA0.41893060
85RET0.41089438
86SGK20.40447383
87STK380.39742291
88RPS6KL10.39720391
89RPS6KC10.39720391
90MAPKAPK20.38582965
91NLK0.37343316
92RPS6KA60.35147475
93CAMKK20.33632577
94MOS0.33233413
95PRKCZ0.28821211
96CAMKK10.28492533
97PRKG20.27961932
98PRKCD0.27921657
99FGFR40.27822193
100WNK10.27499959

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.14781919
2* Osteoclast differentiation_Homo sapiens_hsa043803.08594204
3Staphylococcus aureus infection_Homo sapiens_hsa051502.96610009
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.39657120
5Graft-versus-host disease_Homo sapiens_hsa053322.31857822
6Tuberculosis_Homo sapiens_hsa051522.28444510
7Allograft rejection_Homo sapiens_hsa053302.23424952
8B cell receptor signaling pathway_Homo sapiens_hsa046622.19052857
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.17482233
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08575102
11Autoimmune thyroid disease_Homo sapiens_hsa053202.06904848
12Primary immunodeficiency_Homo sapiens_hsa053402.03283114
13Malaria_Homo sapiens_hsa051442.01392504
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.01304735
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83079167
16Hematopoietic cell lineage_Homo sapiens_hsa046401.80630202
17Measles_Homo sapiens_hsa051621.77672362
18Chemokine signaling pathway_Homo sapiens_hsa040621.76337754
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.72094633
20Legionellosis_Homo sapiens_hsa051341.68953362
21Type I diabetes mellitus_Homo sapiens_hsa049401.65271657
22Antigen processing and presentation_Homo sapiens_hsa046121.65086818
23T cell receptor signaling pathway_Homo sapiens_hsa046601.63583305
24Acute myeloid leukemia_Homo sapiens_hsa052211.60802321
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59480636
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.57178721
27Toxoplasmosis_Homo sapiens_hsa051451.50232723
28Influenza A_Homo sapiens_hsa051641.49873340
29Phagosome_Homo sapiens_hsa041451.49490836
30Viral myocarditis_Homo sapiens_hsa054161.43098006
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.38564719
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38168306
33African trypanosomiasis_Homo sapiens_hsa051431.35843947
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32389443
35Herpes simplex infection_Homo sapiens_hsa051681.28256156
36Platelet activation_Homo sapiens_hsa046111.26847693
37TNF signaling pathway_Homo sapiens_hsa046681.26789509
38Asthma_Homo sapiens_hsa053101.26115335
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.25136793
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.23097186
41Non-small cell lung cancer_Homo sapiens_hsa052231.19470909
42Hepatitis B_Homo sapiens_hsa051611.12669295
43Pertussis_Homo sapiens_hsa051331.12074782
44Rheumatoid arthritis_Homo sapiens_hsa053231.07332502
45Other glycan degradation_Homo sapiens_hsa005111.07193769
46Salmonella infection_Homo sapiens_hsa051321.06751371
47Shigellosis_Homo sapiens_hsa051311.04337115
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03213982
49Hepatitis C_Homo sapiens_hsa051601.01248987
50Pancreatic cancer_Homo sapiens_hsa052120.96983471
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94522681
52Apoptosis_Homo sapiens_hsa042100.87892324
53VEGF signaling pathway_Homo sapiens_hsa043700.86987446
54Chronic myeloid leukemia_Homo sapiens_hsa052200.86874131
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84250941
56Lysosome_Homo sapiens_hsa041420.83957870
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83704108
58Renal cell carcinoma_Homo sapiens_hsa052110.79481730
59Prolactin signaling pathway_Homo sapiens_hsa049170.77201719
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.76625165
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76234274
62Endocytosis_Homo sapiens_hsa041440.75810268
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74958824
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.74417538
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70509623
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68522677
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.68302212
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65795917
69FoxO signaling pathway_Homo sapiens_hsa040680.65717086
70Amoebiasis_Homo sapiens_hsa051460.64532111
71Dorso-ventral axis formation_Homo sapiens_hsa043200.63812279
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63039645
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61678092
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.61568476
75Epstein-Barr virus infection_Homo sapiens_hsa051690.59878558
76Notch signaling pathway_Homo sapiens_hsa043300.59760492
77GnRH signaling pathway_Homo sapiens_hsa049120.59149433
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57794051
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57429222
80Choline metabolism in cancer_Homo sapiens_hsa052310.56844085
81Endometrial cancer_Homo sapiens_hsa052130.55504757
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55291012
83Viral carcinogenesis_Homo sapiens_hsa052030.54803233
84Regulation of autophagy_Homo sapiens_hsa041400.52768905
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.52713554
86Type II diabetes mellitus_Homo sapiens_hsa049300.50885647
87HIF-1 signaling pathway_Homo sapiens_hsa040660.49902234
88Insulin resistance_Homo sapiens_hsa049310.46870443
89MAPK signaling pathway_Homo sapiens_hsa040100.46451863
90Inositol phosphate metabolism_Homo sapiens_hsa005620.45617360
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45462524
92HTLV-I infection_Homo sapiens_hsa051660.45417070
93Colorectal cancer_Homo sapiens_hsa052100.44796927
94mTOR signaling pathway_Homo sapiens_hsa041500.44746657
95Rap1 signaling pathway_Homo sapiens_hsa040150.44391905
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43958176
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.41738227
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40354296
99Collecting duct acid secretion_Homo sapiens_hsa049660.38849612
100ErbB signaling pathway_Homo sapiens_hsa040120.35808012

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