SIPA1L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of cell adhesion, cell polarity, and organization of the cytoskeleton. Like other members of the family, the protein encoded by this gene contains RapGAP and PDZ domains. In addition, this protein contains a C-terminal leucine zipper domain. This gene is proposed to function in epithelial cell morphogenesis and establishment or maintenance of polarity. Consistently, expression of the protein in cell culture showed localization to cell-cell borders in apical regions, and downregulation of the gene in 3D Caco2 cell culture resulted in abnormal cell polarity and morphogenesis. Allelic variants of this gene have been associated with congenital cataracts in humans. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-tyrosine autophosphorylation (GO:0038083)3.86688710
2endothelial cell chemotaxis (GO:0035767)3.82838175
3semaphorin-plexin signaling pathway (GO:0071526)3.59472566
4glucocorticoid receptor signaling pathway (GO:0042921)3.57223486
5negative regulation of cell size (GO:0045792)3.52433080
6negative regulation of fatty acid transport (GO:2000192)3.44994677
7positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.37098221
8mannose metabolic process (GO:0006013)3.36739897
9positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.28787606
10positive regulation of protein deacetylation (GO:0090312)3.24547923
11regulation of fatty acid beta-oxidation (GO:0031998)3.22864659
12negative regulation of viral release from host cell (GO:1902187)3.19858169
13hemidesmosome assembly (GO:0031581)3.18182728
14adherens junction assembly (GO:0034333)3.17702632
15cell-substrate adherens junction assembly (GO:0007045)3.17530944
16focal adhesion assembly (GO:0048041)3.17530944
17cytoskeletal anchoring at plasma membrane (GO:0007016)3.17251380
18activation of Rac GTPase activity (GO:0032863)3.14786700
19epithelial cell-cell adhesion (GO:0090136)3.12485256
20regulation of cholesterol homeostasis (GO:2000188)3.11219743
21regulation of glucose import in response to insulin stimulus (GO:2001273)3.06144766
22positive regulation of Cdc42 GTPase activity (GO:0043089)3.02592720
23regulation of water loss via skin (GO:0033561)3.02264175
24cellular response to virus (GO:0098586)3.00557145
25bundle of His cell to Purkinje myocyte communication (GO:0086069)2.96265441
26regulation of histone H3-K27 methylation (GO:0061085)2.92917715
27vocalization behavior (GO:0071625)2.92485761
28Golgi transport vesicle coating (GO:0048200)2.91216084
29COPI coating of Golgi vesicle (GO:0048205)2.91216084
30corticosteroid receptor signaling pathway (GO:0031958)2.91149426
31negative regulation of hormone biosynthetic process (GO:0032353)2.91136285
32negative regulation of hormone metabolic process (GO:0032351)2.91136285
33receptor catabolic process (GO:0032801)2.89261701
34positive regulation of gene expression, epigenetic (GO:0045815)2.88853317
35actin filament depolymerization (GO:0030042)2.87755309
36cell-cell junction maintenance (GO:0045217)2.87296944
37ear development (GO:0043583)2.84955593
38regulation of apoptotic process involved in morphogenesis (GO:1902337)2.83654868
39sodium ion export (GO:0071436)2.82336358
40locomotory exploration behavior (GO:0035641)2.82307572
41gonadal mesoderm development (GO:0007506)2.81449416
42regulation of endothelial cell chemotaxis (GO:2001026)2.80670176
43regulation of extracellular matrix disassembly (GO:0010715)2.80467409
44negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.78991087
45atrioventricular valve morphogenesis (GO:0003181)2.78435263
46regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78286028
47regulation of histone deacetylation (GO:0031063)2.73247034
48regulation of NFAT protein import into nucleus (GO:0051532)2.71640016
49regulation of viral release from host cell (GO:1902186)2.70212975
50glial cell proliferation (GO:0014009)2.66977350
51myelin maintenance (GO:0043217)2.64772768
52positive regulation of fatty acid beta-oxidation (GO:0032000)2.64112286
53planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63541669
54protein localization to endosome (GO:0036010)2.63405851
55signal complex assembly (GO:0007172)2.61475720
56columnar/cuboidal epithelial cell development (GO:0002066)2.61010639
57establishment of skin barrier (GO:0061436)2.60592723
58inner ear receptor cell development (GO:0060119)2.59900236
59apoptotic process involved in morphogenesis (GO:0060561)2.58981441
60glandular epithelial cell differentiation (GO:0002067)2.55245194
61chemosensory behavior (GO:0007635)2.54887445
62actin filament bundle organization (GO:0061572)2.54784778
63actin filament bundle assembly (GO:0051017)2.54784778
64regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54537443
65cell volume homeostasis (GO:0006884)2.52027473
66synaptic vesicle endocytosis (GO:0048488)2.51553994
67synaptic vesicle docking involved in exocytosis (GO:0016081)2.51155157
68intestinal epithelial cell development (GO:0060576)2.48901878
69positive regulation of synapse maturation (GO:0090129)2.48005649
70positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.47857538
71positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.47787993
72regulation of protein polyubiquitination (GO:1902914)2.47108849
73positive regulation of macroautophagy (GO:0016239)2.46239098
74cellular potassium ion homeostasis (GO:0030007)2.45728510
75protein retention in ER lumen (GO:0006621)2.44964279
76COPII vesicle coating (GO:0048208)2.43854875
77regulation of clathrin-mediated endocytosis (GO:2000369)2.43801328
78synaptic vesicle maturation (GO:0016188)2.43284868
79histone H3-K36 demethylation (GO:0070544)2.42944726
80positive regulation of CREB transcription factor activity (GO:0032793)2.42906725
81lung epithelial cell differentiation (GO:0060487)2.42658977
82establishment of apical/basal cell polarity (GO:0035089)2.42414218
83lung cell differentiation (GO:0060479)2.41818969
84embryonic process involved in female pregnancy (GO:0060136)2.39810138
85cell junction maintenance (GO:0034331)2.39380033
86intracellular estrogen receptor signaling pathway (GO:0030520)2.38744573
87basement membrane organization (GO:0071711)2.38559301
88glandular epithelial cell development (GO:0002068)2.37966984
89regulation of ARF protein signal transduction (GO:0032012)2.37744769
90histone H3-K9 demethylation (GO:0033169)2.36135152
91histone H3-K4 trimethylation (GO:0080182)2.35677857
92positive regulation of blood vessel endothelial cell migration (GO:0043536)2.35081620
93macroautophagy (GO:0016236)2.35013742
94membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.34555266
95multicellular organismal water homeostasis (GO:0050891)2.34282881
96ionotropic glutamate receptor signaling pathway (GO:0035235)2.34017206
97branching involved in mammary gland duct morphogenesis (GO:0060444)2.31724764
98Rho protein signal transduction (GO:0007266)2.31224971
99biotin metabolic process (GO:0006768)2.30766741
100regulation of neuron migration (GO:2001222)2.29920586
101retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.29069151
102dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.27857092
103innervation (GO:0060384)2.27474407
104negative regulation of osteoblast proliferation (GO:0033689)2.27138955
105cytoplasmic mRNA processing body assembly (GO:0033962)2.27014915
106insulin-like growth factor receptor signaling pathway (GO:0048009)2.26562800
107regulation of protein deacetylation (GO:0090311)2.26461138
108striated muscle atrophy (GO:0014891)2.26074799
109regulation of Cdc42 GTPase activity (GO:0043088)2.25984195
110positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.24991486
111activation of JUN kinase activity (GO:0007257)2.24724422
112trophectodermal cell differentiation (GO:0001829)2.24679428
113regulation of male gonad development (GO:2000018)2.24380718
114histone H3-K4 methylation (GO:0051568)2.23961642
115dendritic spine organization (GO:0097061)2.22705448
116establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.19198601
117dendritic spine morphogenesis (GO:0060997)2.18896635
118regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.18888497
119protein targeting to Golgi (GO:0000042)2.18283221
120regulation of synapse maturation (GO:0090128)2.17909475
121retrograde transport, vesicle recycling within Golgi (GO:0000301)2.15193035
122membrane repolarization during action potential (GO:0086011)2.13946814
123ovulation cycle (GO:0042698)2.13857646
124embryonic camera-type eye morphogenesis (GO:0048596)2.12969213
125regulation of glutamate receptor signaling pathway (GO:1900449)2.12305048
126desmosome organization (GO:0002934)2.11020920
127stress fiber assembly (GO:0043149)2.08358605
128cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.07710054
129positive regulation of histone deacetylation (GO:0031065)2.06249539
130negative regulation of keratinocyte proliferation (GO:0010839)2.06212582
131type B pancreatic cell development (GO:0003323)2.05364105
132positive regulation of p38MAPK cascade (GO:1900745)2.05364091
133establishment of protein localization to Golgi (GO:0072600)2.03858013
134lens fiber cell differentiation (GO:0070306)2.03482477
135layer formation in cerebral cortex (GO:0021819)2.01531315
136epithelial cell fate commitment (GO:0072148)2.00534203
137regulation of neuronal synaptic plasticity (GO:0048168)2.00479391
138regulation of p38MAPK cascade (GO:1900744)2.00467400
139embryonic eye morphogenesis (GO:0048048)2.00442487
140bone morphogenesis (GO:0060349)1.99628932
141histone H4-K12 acetylation (GO:0043983)1.99241661
142synaptic transmission, glutamatergic (GO:0035249)1.98461619
143stress granule assembly (GO:0034063)1.98381911
144regulation of hippo signaling (GO:0035330)1.97883624
145regulation of ARF GTPase activity (GO:0032312)1.97202963
146filopodium assembly (GO:0046847)1.97020397
147regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.94855685
148central nervous system projection neuron axonogenesis (GO:0021952)1.94240230
149embryonic retina morphogenesis in camera-type eye (GO:0060059)1.93345949
150cerebellar Purkinje cell differentiation (GO:0021702)1.92458849
151ganglion development (GO:0061548)1.91860212
152positive regulation of Rac GTPase activity (GO:0032855)1.89582587
153cellular response to vitamin D (GO:0071305)1.89357218
154positive regulation of vesicle fusion (GO:0031340)1.88382904
155glutamate receptor signaling pathway (GO:0007215)1.87876664
156cell communication by electrical coupling (GO:0010644)1.87379768
157cell-substrate junction assembly (GO:0007044)1.87108062
158membrane repolarization (GO:0086009)1.85621153
159positive regulation of dendritic spine morphogenesis (GO:0061003)1.85324797
160regulation of integrin activation (GO:0033623)1.84963056
161dorsal/ventral axis specification (GO:0009950)1.83704309
162collecting duct development (GO:0072044)1.83380938
163regulation of long-term neuronal synaptic plasticity (GO:0048169)1.83233425
164dendrite morphogenesis (GO:0048813)1.80037459
165regulation of synaptic vesicle exocytosis (GO:2000300)1.78884026
166long-term memory (GO:0007616)1.77723549
167histone lysine demethylation (GO:0070076)1.77496508
168regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.77285867
169activation of Ras GTPase activity (GO:0032856)1.76814349
170potassium ion homeostasis (GO:0055075)1.76547959
171regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)1.76149872
172neuron projection extension involved in neuron projection guidance (GO:1902284)1.75808247
173axon extension involved in axon guidance (GO:0048846)1.75808247
174exploration behavior (GO:0035640)1.75595309
175histone lysine methylation (GO:0034968)1.74971453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.02353685
2MYC_22102868_ChIP-Seq_BL_Human2.90572008
3EZH2_22144423_ChIP-Seq_EOC_Human2.41318947
4ELK3_25401928_ChIP-Seq_HUVEC_Human2.41242194
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.40458833
6DROSHA_22980978_ChIP-Seq_HELA_Human2.25212494
7VDR_21846776_ChIP-Seq_THP-1_Human2.19698635
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07081301
9* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.00067392
10KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.98777670
11IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97186138
12ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94720169
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92333551
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89936128
15* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87371261
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85920871
17RNF2_27304074_Chip-Seq_ESCs_Mouse1.78268066
18KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.74748301
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73763839
20KDM2B_26808549_Chip-Seq_K562_Human1.72852381
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72532743
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72532743
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70710485
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68103888
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67530300
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67412958
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65298384
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63164132
29TP53_22127205_ChIP-Seq_IMR90_Human1.62375093
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61142994
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60782470
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57839911
33ZNF263_19887448_ChIP-Seq_K562_Human1.56760198
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55113075
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53995289
36GBX2_23144817_ChIP-Seq_PC3_Human1.53738339
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52933456
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52329448
39SMC4_20622854_ChIP-Seq_HELA_Human1.50403157
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49617203
41* CDX2_20551321_ChIP-Seq_CACO-2_Human1.47428427
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46914551
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.46088711
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.44979387
45* AHR_22903824_ChIP-Seq_MCF-7_Human1.44433419
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44396612
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43486002
48CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43415719
49DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41733566
50WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41688734
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.41148013
52GATA6_25053715_ChIP-Seq_YYC3_Human1.40392668
53VDR_24763502_ChIP-Seq_THP-1_Human1.38856391
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38153348
55P68_20966046_ChIP-Seq_HELA_Human1.37315079
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36341766
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.35385719
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.35323298
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33986137
60* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33907857
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33852475
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.33562914
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31876722
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31738872
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30916990
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30462274
67ATF3_27146783_Chip-Seq_COLON_Human1.29632672
68* TP63_22573176_ChIP-Seq_HFKS_Human1.29029525
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.29020136
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29003350
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.28714709
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27560311
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27531491
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.26531597
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26368447
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24551730
77* ARNT_22903824_ChIP-Seq_MCF-7_Human1.24311466
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.23335925
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23012297
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22939845
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22448361
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22146637
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22146637
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22055032
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21835942
86* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21724902
87FOXA2_19822575_ChIP-Seq_HepG2_Human1.21538147
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21334762
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20279980
90* REST_21632747_ChIP-Seq_MESCs_Mouse1.20241774
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19044943
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.18551148
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.17539082
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14989026
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.14289534
96CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12770335
97PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11737211
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11512752
99TP53_16413492_ChIP-PET_HCT116_Human1.11502392
100KDM2B_26808549_Chip-Seq_DND41_Human1.11482464
101KLF5_25053715_ChIP-Seq_YYC3_Human1.10595884
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09754815
103KDM2B_26808549_Chip-Seq_JURKAT_Human1.09494432
104* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09177523
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09131136
106* RUNX1_27514584_Chip-Seq_MCF-7_Human1.07926347
107RING1B_27294783_Chip-Seq_ESCs_Mouse1.07867059
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.07866118
109* AR_19668381_ChIP-Seq_PC3_Human1.07594910
110TCF4_18268006_ChIP-ChIP_LS174T_Human1.07511444
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.06887964
112* TCF7_22412390_ChIP-Seq_EML_Mouse1.04874016
113ESR1_21235772_ChIP-Seq_MCF-7_Human1.04585815
114MAF_26560356_Chip-Seq_TH1_Human1.04485156
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03816439
116SA1_27219007_Chip-Seq_ERYTHROID_Human1.03394967
117PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02320539
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02111008
119PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00993328
120CTCF_27219007_Chip-Seq_Bcells_Human1.00978556
121RUNX1_22412390_ChIP-Seq_EML_Mouse1.00347245
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.99130383
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99015207
124RXR_22108803_ChIP-Seq_LS180_Human0.98716572
125BCOR_27268052_Chip-Seq_Bcells_Human0.98322479
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98039875
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97514382
128* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96601387
129CHD1_26751641_Chip-Seq_LNCaP_Human0.96066874
130KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94201682
131KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93897568
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93543926
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.93331950
134TBX20_22080862_ChIP-Seq_HEART_Mouse0.93115507
135TBX20_22328084_ChIP-Seq_HEART_Mouse0.93115507
136GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92682339
137TET1_21490601_ChIP-Seq_MESCs_Mouse0.92235884
138STAT3_23295773_ChIP-Seq_U87_Human0.91968147
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91892161
140SMAD4_21799915_ChIP-Seq_A2780_Human0.91430861
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91055094
142TP63_19390658_ChIP-ChIP_HaCaT_Human0.90376952
143LXR_22292898_ChIP-Seq_THP-1_Human0.90171599
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89857344
145* SPI1_23127762_ChIP-Seq_K562_Human0.89542934
146SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89145019
147CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88955131
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88829696
149FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88785486
150ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88434609
151RACK7_27058665_Chip-Seq_MCF-7_Human0.87625609
152EGR1_19374776_ChIP-ChIP_THP-1_Human0.87381953
153AR_21572438_ChIP-Seq_LNCaP_Human0.87132739
154ERG_21242973_ChIP-ChIP_JURKAT_Human0.84892135
155* TP53_23651856_ChIP-Seq_MEFs_Mouse0.84490515
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.84359624
157P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83982747
158CREB1_26743006_Chip-Seq_LNCaP_Human0.83951700
159* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83231241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.78521976
2MP0003283_abnormal_digestive_organ3.19143776
3MP0000569_abnormal_digit_pigmentation2.98415186
4MP0002166_altered_tumor_susceptibility2.79202564
5MP0002877_abnormal_melanocyte_morpholog2.54889400
6MP0004264_abnormal_extraembryonic_tissu2.52253822
7MP0003045_fibrosis2.46531759
8MP0005076_abnormal_cell_differentiation2.45357015
9MP0000678_abnormal_parathyroid_gland2.43706286
10MP0010234_abnormal_vibrissa_follicle2.42634326
11MP0009780_abnormal_chondrocyte_physiolo2.37191090
12MP0001873_stomach_inflammation2.30730763
13MP0001348_abnormal_lacrimal_gland2.20402204
14MP0005451_abnormal_body_composition2.09333031
15MP0003787_abnormal_imprinting2.02449025
16MP0005360_urolithiasis1.92644941
17MP0004185_abnormal_adipocyte_glucose1.87444210
18MP0002006_tumorigenesis1.85243366
19MP0000003_abnormal_adipose_tissue1.82027037
20MP0008961_abnormal_basal_metabolism1.79362339
21MP0000537_abnormal_urethra_morphology1.74364100
22MP0001849_ear_inflammation1.74042559
23MP0002909_abnormal_adrenal_gland1.72611398
24MP0002234_abnormal_pharynx_morphology1.71120448
25MP0001346_abnormal_lacrimal_gland1.64535042
26MP0004858_abnormal_nervous_system1.64384913
27MP0000579_abnormal_nail_morphology1.61501715
28MP0003300_gastrointestinal_ulcer1.58342068
29MP0000462_abnormal_digestive_system1.57369186
30MP0003705_abnormal_hypodermis_morpholog1.53543539
31MP0000538_abnormal_urinary_bladder1.50901107
32MP0003635_abnormal_synaptic_transmissio1.50323124
33MP0005310_abnormal_salivary_gland1.49571256
34MP0005501_abnormal_skin_physiology1.49484888
35MP0000516_abnormal_urinary_system1.47621440
36MP0005367_renal/urinary_system_phenotyp1.47621440
37MP0000733_abnormal_muscle_development1.47582297
38MP0001188_hyperpigmentation1.46819530
39MP0005670_abnormal_white_adipose1.46465809
40MP0002249_abnormal_larynx_morphology1.42481990
41MP0005248_abnormal_Harderian_gland1.41348774
42MP0006292_abnormal_olfactory_placode1.40304028
43MP0002697_abnormal_eye_size1.39467244
44MP0003183_abnormal_peptide_metabolism1.38392448
45MP0003941_abnormal_skin_development1.37612772
46MP0004270_analgesia1.37100332
47MP0005375_adipose_tissue_phenotype1.35743144
48MP0010352_gastrointestinal_tract_polyps1.34522031
49MP0004885_abnormal_endolymph1.33214250
50MP0005623_abnormal_meninges_morphology1.32998421
51MP0000013_abnormal_adipose_tissue1.32712391
52MP0003119_abnormal_digestive_system1.32433362
53MP0009384_cardiac_valve_regurgitation1.31463598
54MP0002063_abnormal_learning/memory/cond1.25929341
55MP0005257_abnormal_intraocular_pressure1.24581332
56MP0004510_myositis1.22602441
57MP0000767_abnormal_smooth_muscle1.19833737
58MP0001216_abnormal_epidermal_layer1.19619880
59MP0005645_abnormal_hypothalamus_physiol1.19232860
60MP0002254_reproductive_system_inflammat1.17725843
61MP0009840_abnormal_foam_cell1.15481080
62MP0008995_early_reproductive_senescence1.14745894
63MP0005023_abnormal_wound_healing1.13659147
64MP0004947_skin_inflammation1.11746995
65MP0002089_abnormal_postnatal_growth/wei1.10895060
66MP0001765_abnormal_ion_homeostasis1.10700817
67MP0005666_abnormal_adipose_tissue1.10605272
68MP0002138_abnormal_hepatobiliary_system1.10205101
69MP0000613_abnormal_salivary_gland1.09533775
70MP0009278_abnormal_bone_marrow1.08093033
71MP0003115_abnormal_respiratory_system1.07312124
72MP0003279_aneurysm1.07033449
73MP0000534_abnormal_ureter_morphology1.06507343
74MP0000470_abnormal_stomach_morphology1.06146958
75MP0010678_abnormal_skin_adnexa1.05636750
76MP0000477_abnormal_intestine_morphology1.04885391
77MP0002896_abnormal_bone_mineralization1.03273239
78MP0002693_abnormal_pancreas_physiology1.02915916
79MP0002928_abnormal_bile_duct1.02314990
80MP0003566_abnormal_cell_adhesion1.02080639
81MP0002572_abnormal_emotion/affect_behav1.00806791
82MP0000467_abnormal_esophagus_morphology1.00217127
83MP0003879_abnormal_hair_cell0.98884073
84MP0001502_abnormal_circadian_rhythm0.98386938
85MP0004808_abnormal_hematopoietic_stem0.97611489
86MP0005220_abnormal_exocrine_pancreas0.96943637
87MP0002396_abnormal_hematopoietic_system0.96080795
88MP0000566_synostosis0.94597404
89MP0010386_abnormal_urinary_bladder0.94383532
90MP0003866_abnormal_defecation0.93974377
91MP0005174_abnormal_tail_pigmentation0.93933642
92MP0005253_abnormal_eye_physiology0.92238699
93MP0001944_abnormal_pancreas_morphology0.92212232
94MP0003935_abnormal_craniofacial_develop0.92024450
95MP0005551_abnormal_eye_electrophysiolog0.91984695
96MP0003868_abnormal_feces_composition0.91941884
97MP0010155_abnormal_intestine_physiology0.91437145
98MP0005621_abnormal_cell_physiology0.91199573
99MP0003890_abnormal_embryonic-extraembry0.90887895
100MP0002098_abnormal_vibrissa_morphology0.90885080
101MP0004782_abnormal_surfactant_physiolog0.89947997
102MP0005409_darkened_coat_color0.89908151
103MP0002116_abnormal_craniofacial_bone0.88817286
104MP0001486_abnormal_startle_reflex0.85850682
105MP0005499_abnormal_olfactory_system0.85031871
106MP0005394_taste/olfaction_phenotype0.85031871
107MP0002060_abnormal_skin_morphology0.84963387
108MP0000631_abnormal_neuroendocrine_gland0.84533739
109MP0002653_abnormal_ependyma_morphology0.84456943
110MP0000377_abnormal_hair_follicle0.83727824
111MP0008569_lethality_at_weaning0.83534604
112MP0003091_abnormal_cell_migration0.82951167
113MP0004233_abnormal_muscle_weight0.82364103
114MP0000432_abnormal_head_morphology0.81451870
115MP0000428_abnormal_craniofacial_morphol0.81105271
116MP0003075_altered_response_to0.80064667
117MP0004272_abnormal_basement_membrane0.79708248
118MP0002168_other_aberrant_phenotype0.79463287
119MP0008004_abnormal_stomach_pH0.79292029
120MP0003755_abnormal_palate_morphology0.79113862
121MP0003453_abnormal_keratinocyte_physiol0.78357320
122MP0001177_atelectasis0.78286845
123MP0000383_abnormal_hair_follicle0.78125109
124MP0003385_abnormal_body_wall0.78103920
125MP0002822_catalepsy0.77887219
126MP0001666_abnormal_nutrient_absorption0.77845797
127MP0003763_abnormal_thymus_physiology0.77786437
128MP0000049_abnormal_middle_ear0.77299587
129MP0002796_impaired_skin_barrier0.77296514
130MP0002970_abnormal_white_adipose0.76836279
131MP0001664_abnormal_digestion0.74704827
132MP0002557_abnormal_social/conspecific_i0.74433014
133MP0003191_abnormal_cellular_cholesterol0.73575748
134MP0003172_abnormal_lysosome_physiology0.72293444
135MP0002136_abnormal_kidney_physiology0.72245131
136MP0006072_abnormal_retinal_apoptosis0.70965645
137MP0009745_abnormal_behavioral_response0.70856955
138MP0002177_abnormal_outer_ear0.70608362
139MP0002925_abnormal_cardiovascular_devel0.70095740
140MP0000627_abnormal_mammary_gland0.69461661
141MP0001790_abnormal_immune_system0.69450948
142MP0005387_immune_system_phenotype0.69450948
143MP0000762_abnormal_tongue_morphology0.69325157
144MP0006138_congestive_heart_failure0.69310630
145MP0000955_abnormal_spinal_cord0.69170272
146MP0001730_embryonic_growth_arrest0.68868550
147MP0001501_abnormal_sleep_pattern0.68801819
148MP0005167_abnormal_blood-brain_barrier0.68591526
149MP0010771_integument_phenotype0.68538701
150MP0002009_preneoplasia0.67495350
151MP0009931_abnormal_skin_appearance0.67348755
152MP0009643_abnormal_urine_homeostasis0.65153733
153MP0005381_digestive/alimentary_phenotyp0.62484053
154MP0002086_abnormal_extraembryonic_tissu0.61962868

Predicted human phenotypes

RankGene SetZ-score
1Broad face (HP:0000283)5.34337028
2Flat acetabular roof (HP:0003180)4.09564528
3Cervical subluxation (HP:0003308)3.54515483
4Nuclear cataract (HP:0100018)3.33096435
5Milia (HP:0001056)3.28330657
6Zonular cataract (HP:0010920)2.83082709
7Urethral obstruction (HP:0000796)2.81298635
8Atrophic scars (HP:0001075)2.78215385
9Sparse lateral eyebrow (HP:0005338)2.74777569
10Advanced eruption of teeth (HP:0006288)2.57660099
11Unilateral renal agenesis (HP:0000122)2.50582112
12Stridor (HP:0010307)2.50030760
13Abnormality of the nasal septum (HP:0000419)2.44818875
14Colitis (HP:0002583)2.42619187
15Abnormality of the fingertips (HP:0001211)2.42089960
16Abnormality of the distal phalanges of the toes (HP:0010182)2.41908191
17Distal lower limb amyotrophy (HP:0008944)2.34965141
18Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.33367476
19Shallow orbits (HP:0000586)2.25922842
20Thin bony cortex (HP:0002753)2.25261364
21Macroorchidism (HP:0000053)2.20387700
22Dysmetric saccades (HP:0000641)2.17576134
23Hemorrhage of the eye (HP:0011885)2.17554546
24Obstructive sleep apnea (HP:0002870)2.17409103
25Lip pit (HP:0100267)2.16276306
26Malnutrition (HP:0004395)2.15411241
27Gastrointestinal stroma tumor (HP:0100723)2.14557972
28Progressive sensorineural hearing impairment (HP:0000408)2.14216498
29Short nail (HP:0001799)2.13954924
30Abnormality of the phalanges of the hallux (HP:0010057)2.13532999
31Natal tooth (HP:0000695)2.12891155
32Agammaglobulinemia (HP:0004432)2.09422181
33Hyperacusis (HP:0010780)2.08954382
34Abnormality of the 1st metacarpal (HP:0010009)2.08771609
35Broad metatarsal (HP:0001783)2.08078968
36Flattened epiphyses (HP:0003071)2.07780790
37Cellulitis (HP:0100658)2.07488076
38Abnormality of carpal bone ossification (HP:0006257)2.05041209
39Congenital stationary night blindness (HP:0007642)2.04862732
40Cerebral aneurysm (HP:0004944)2.03721340
41Neonatal hypoglycemia (HP:0001998)2.03298274
42Emphysema (HP:0002097)2.02762609
43Mildly elevated creatine phosphokinase (HP:0008180)2.02690480
44Abnormal ossification of hand bones (HP:0005921)2.02415819
45Ulnar bowing (HP:0003031)2.01954805
46Achilles tendon contracture (HP:0001771)1.98565534
47Dislocated radial head (HP:0003083)1.98542535
48Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.97258965
49Short 1st metacarpal (HP:0010034)1.97258965
50Congenital glaucoma (HP:0001087)1.95032554
51Persistence of primary teeth (HP:0006335)1.94946696
52Febrile seizures (HP:0002373)1.93981178
53Genetic anticipation (HP:0003743)1.92665354
54Volvulus (HP:0002580)1.92648263
55Abnormal vertebral ossification (HP:0100569)1.92555626
56Spinal cord compression (HP:0002176)1.90502527
57Abnormality of the gastric mucosa (HP:0004295)1.90417377
58Hypoplasia of dental enamel (HP:0006297)1.90382955
59Fragile skin (HP:0001030)1.90227487
60Elfin facies (HP:0004428)1.90126733
61Narrow palate (HP:0000189)1.89297264
62Progressive hearing impairment (HP:0001730)1.88671588
63Abnormality of the Achilles tendon (HP:0005109)1.88248604
64Abnormality of the radial head (HP:0003995)1.87313410
65J-shaped sella turcica (HP:0002680)1.87106966
66Neoplasm of the heart (HP:0100544)1.86912398
67Ankyloglossia (HP:0010296)1.85398791
68Septate vagina (HP:0001153)1.85062223
69Gastrointestinal inflammation (HP:0004386)1.83913870
70Osteolytic defects of the phalanges of the hand (HP:0009771)1.82456794
71Osteolytic defects of the hand bones (HP:0009699)1.82456794
72Villous atrophy (HP:0011473)1.77161424
73Abnormality of small intestinal villus morphology (HP:0011472)1.77161424
74Turricephaly (HP:0000262)1.76493498
75Heterotopia (HP:0002282)1.75754058
76Precocious puberty (HP:0000826)1.74858932
77Germ cell neoplasia (HP:0100728)1.72913693
78Uterine leiomyosarcoma (HP:0002891)1.72327337
79Leiomyosarcoma (HP:0100243)1.72327337
80Aneurysm (HP:0002617)1.71405491
81Abnormality of the distal phalanx of the thumb (HP:0009617)1.71016901
82Self-mutilation (HP:0000742)1.69802926
83Hypoplastic labia majora (HP:0000059)1.69600763
84Disproportionate tall stature (HP:0001519)1.69397470
85Testicular atrophy (HP:0000029)1.69328868
86Shawl scrotum (HP:0000049)1.69051450
87Abnormality of the columella (HP:0009929)1.69020388
88Abdominal distention (HP:0003270)1.68043884
89Hyperactive renin-angiotensin system (HP:0000841)1.67607005
90Increased connective tissue (HP:0009025)1.67258933
91Severe short stature (HP:0003510)1.66599709
92Long eyelashes (HP:0000527)1.66250564
93Aplasia cutis congenita (HP:0001057)1.66162680
94Abnormal hand bone ossification (HP:0010660)1.64955777
95Abnormality of the aortic arch (HP:0012303)1.64736571
96Alopecia of scalp (HP:0002293)1.64691239
97Tibial bowing (HP:0002982)1.64611384
98Abnormal glucose tolerance (HP:0001952)1.63869578
99Overgrowth (HP:0001548)1.63709755
100Absent frontal sinuses (HP:0002688)1.63683926
101Transitional cell carcinoma of the bladder (HP:0006740)1.62938973
102Focal segmental glomerulosclerosis (HP:0000097)1.62290743
103Laryngomalacia (HP:0001601)1.61779256
104Abnormality of the labia majora (HP:0012881)1.61684834
105Hand muscle atrophy (HP:0009130)1.61544768
106Anal stenosis (HP:0002025)1.61514078
107Plantar hyperkeratosis (HP:0007556)1.60797096
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.60672675
109Tracheomalacia (HP:0002779)1.60511800
110Renal duplication (HP:0000075)1.60422846
111Urinary glycosaminoglycan excretion (HP:0003541)1.60252451
112Mucopolysacchariduria (HP:0008155)1.60252451
113Protrusio acetabuli (HP:0003179)1.59935542
114Short phalanx of the thumb (HP:0009660)1.59747058
115Progressive cerebellar ataxia (HP:0002073)1.59565775
116Decreased circulating renin level (HP:0003351)1.59042263
117Smooth philtrum (HP:0000319)1.58258003
118Lymphangioma (HP:0100764)1.57733238
119Pili torti (HP:0003777)1.57358458
120Abnormality of the lower motor neuron (HP:0002366)1.56801969
121Acanthosis nigricans (HP:0000956)1.56505854
122Annular pancreas (HP:0001734)1.55657029
123Trigonocephaly (HP:0000243)1.55369260
124Insomnia (HP:0100785)1.52890165
125Choroideremia (HP:0001139)1.52394095
126Amblyopia (HP:0000646)1.52154114
127Upper limb amyotrophy (HP:0009129)1.51424203
128Distal upper limb amyotrophy (HP:0007149)1.51424203
129Ureteral stenosis (HP:0000071)1.50359565
130Aplasia involving bones of the upper limbs (HP:0009823)1.49929756
131Aplasia of the phalanges of the hand (HP:0009802)1.49929756
132Aplasia involving bones of the extremities (HP:0009825)1.49929756
133Long palpebral fissure (HP:0000637)1.49872392
134Flat cornea (HP:0007720)1.49824195
135Renovascular hypertension (HP:0100817)1.49789915
136Ureteral obstruction (HP:0006000)1.49604133
137Open mouth (HP:0000194)1.49322019
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.48861333
139Congenital sensorineural hearing impairment (HP:0008527)1.48683777
140Tented upper lip vermilion (HP:0010804)1.48287014
141Bony spicule pigmentary retinopathy (HP:0007737)1.48005577
142Bladder neoplasm (HP:0009725)1.46773197
143Bladder carcinoma (HP:0002862)1.46773197
144Aqueductal stenosis (HP:0002410)1.46677310
145Pointed chin (HP:0000307)1.46450556
146Obsessive-compulsive behavior (HP:0000722)1.46418514
147Epileptic encephalopathy (HP:0200134)1.45894544
148Abnormality of the parietal bone (HP:0002696)1.45056865
149Onycholysis (HP:0001806)1.44806997
150Broad thumb (HP:0011304)1.44085276
151Hyperkalemia (HP:0002153)1.41779544
152Action tremor (HP:0002345)1.41548258
153Pigmentary retinal degeneration (HP:0001146)1.40494206
154Hyperparathyroidism (HP:0000843)1.40274321
155Skin pits (HP:0100276)1.39958708
156Rectal prolapse (HP:0002035)1.39640990
157Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.39086823
158Mask-like facies (HP:0000298)1.38552364
159Hypoplastic nipples (HP:0002557)1.38076691
160Spinal muscular atrophy (HP:0007269)1.34799281
161Right ventricular cardiomyopathy (HP:0011663)1.34670195
162Abnormality of oral frenula (HP:0000190)1.33038897
163Bronchomalacia (HP:0002780)1.32959804
164Overriding aorta (HP:0002623)1.32572599
165Cutaneous finger syndactyly (HP:0010554)1.32260216
166Hemiplegia (HP:0002301)1.32208030
167Oligodontia (HP:0000677)1.31956850
168Abnormality of mucopolysaccharide metabolism (HP:0011020)1.31735282
169Abnormality of glycosaminoglycan metabolism (HP:0004371)1.31735282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.90014330
2MST1R2.98269150
3SMG12.95903943
4PRKD32.77477251
5RIPK12.53226298
6NTRK32.43015897
7EPHA22.16405734
8ICK2.02706710
9LATS12.00535478
10TAOK31.99348049
11INSRR1.94175078
12CAMK1G1.90562959
13PKN21.86969829
14PRPF4B1.80669046
15AKT31.79459835
16DDR21.79395828
17PDGFRA1.70432875
18PRKD21.67916240
19CAMK1D1.62551285
20BRD41.60045952
21BMX1.49654577
22FRK1.47032350
23STK381.45881832
24SIK21.42351345
25MET1.41399497
26MAP4K11.39987829
27PTK61.39225840
28MAPK151.38311722
29MAP3K21.38293761
30CDC42BPA1.33289851
31FGFR41.31608148
32HIPK21.31532406
33EPHA41.30701506
34SIK11.28775938
35PTK21.23514873
36RIPK41.23175288
37TAOK11.22623170
38DMPK1.19484765
39SGK31.18698752
40MARK21.18259666
41ERN11.16512954
42MAP3K101.15558645
43PAK61.07667429
44CHUK1.06777265
45PDGFRB1.05292104
46FER1.02066558
47PRKCI1.01812489
48WNK11.01636513
49MAP3K70.99664172
50ALK0.99370151
51PRKCH0.98824926
52CAMKK10.96244563
53TTN0.94033393
54SGK10.92097544
55MAP3K10.91850756
56IRAK20.91811425
57MTOR0.91525560
58MAP3K90.87945793
59ERBB20.87915912
60MAPK110.87819401
61TYRO30.87381294
62IRAK40.82845621
63SGK20.82824408
64TRIB30.80778574
65EEF2K0.79641233
66EPHB20.77806830
67MAP3K130.77393348
68TNK20.76624769
69LMTK20.75805411
70TESK10.75660323
71CLK10.75136368
72CAMK40.74870187
73MATK0.74312505
74TRPM70.73513607
75DAPK20.70724310
76DYRK1B0.70340591
77EPHA30.67659522
78STK110.67334995
79IRAK30.66412888
80NTRK20.61605644
81RPS6KA20.60764753
82MAP3K30.60738733
83PRKAA20.60550134
84PIM20.60106078
85CAMK10.59222133
86CDK50.59214833
87PRKG20.58737699
88PDPK10.58469476
89UHMK10.57336778
90RPS6KC10.57257848
91RPS6KL10.57257848
92STK30.57181117
93CDK90.57097296
94NTRK10.55743668
95TAOK20.55374754
96NUAK10.54531792
97EPHB10.53081426
98MELK0.52718219
99CSK0.51990682
100PAK40.51981351
101CDK60.51431364
102JAK10.50806710
103GSK3B0.50566305
104MAPK100.49167754
105PRKAA10.48473070
106CSF1R0.48457052
107MAPK140.48254282
108SIK30.48188707
109CDK70.47537672
110TBK10.46086389
111PAK20.45656162
112RPS6KA60.45644298
113SGK4940.43633983
114SGK2230.43633983
115PTK2B0.42476579
116RPS6KA30.42017561
117FGFR30.41730617
118DAPK10.40992895
119MAP3K40.40984890
120MAPK10.40508506
121MAP2K20.39654032
122MAPK80.38596446
123AKT10.38516527
124BLK0.38064929
125PRKD10.37398775
126MAPK70.37152347
127IRAK10.36827504
128GRK10.35637981
129PRKDC0.35363800
130FYN0.35240100
131MAPKAPK30.35117163
132TESK20.33805409
133MAP3K140.32502093
134PRKCZ0.32075432
135PDK10.30126077
136MAP3K110.30086372
137MAPKAPK20.26875237
138MAP3K60.25955944
139MAP3K80.24701493
140RPS6KB20.24622723
141ARAF0.23848348
142FGFR20.22807213
143RET0.22660145

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000612.30663168
2Cyanoamino acid metabolism_Homo sapiens_hsa004601.71557090
3Insulin secretion_Homo sapiens_hsa049111.67593234
4B cell receptor signaling pathway_Homo sapiens_hsa046621.64831565
5Type II diabetes mellitus_Homo sapiens_hsa049301.59045967
6Maturity onset diabetes of the young_Homo sapiens_hsa049501.56019340
7Other glycan degradation_Homo sapiens_hsa005111.53318153
8Long-term potentiation_Homo sapiens_hsa047201.50276661
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45607692
10Salivary secretion_Homo sapiens_hsa049701.40616511
11Circadian entrainment_Homo sapiens_hsa047131.40288540
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38508281
13Carbohydrate digestion and absorption_Homo sapiens_hsa049731.37489451
14Nicotine addiction_Homo sapiens_hsa050331.33676602
15Adherens junction_Homo sapiens_hsa045201.32665580
16Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31476472
17Gastric acid secretion_Homo sapiens_hsa049711.31214173
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30730830
19Olfactory transduction_Homo sapiens_hsa047401.29447755
20Glutamatergic synapse_Homo sapiens_hsa047241.29399638
21Mineral absorption_Homo sapiens_hsa049781.28048558
22Insulin resistance_Homo sapiens_hsa049311.26347213
23Amphetamine addiction_Homo sapiens_hsa050311.24917390
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15790343
25GnRH signaling pathway_Homo sapiens_hsa049121.13902844
26Insulin signaling pathway_Homo sapiens_hsa049101.13253441
27Phototransduction_Homo sapiens_hsa047441.12056688
28Cholinergic synapse_Homo sapiens_hsa047251.11980262
29Hepatitis C_Homo sapiens_hsa051601.11924884
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11383406
31Pancreatic secretion_Homo sapiens_hsa049721.11135694
32AMPK signaling pathway_Homo sapiens_hsa041521.10167005
33Protein digestion and absorption_Homo sapiens_hsa049741.09272655
34Glucagon signaling pathway_Homo sapiens_hsa049221.07571604
35Morphine addiction_Homo sapiens_hsa050321.07226167
36Taste transduction_Homo sapiens_hsa047421.06900256
37Renal cell carcinoma_Homo sapiens_hsa052111.05240918
38Endometrial cancer_Homo sapiens_hsa052131.05054268
39Thyroid cancer_Homo sapiens_hsa052161.04986768
40Dorso-ventral axis formation_Homo sapiens_hsa043201.04898740
41Glioma_Homo sapiens_hsa052141.04320264
42ErbB signaling pathway_Homo sapiens_hsa040121.04169651
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03568642
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.03544509
45Renin secretion_Homo sapiens_hsa049241.03245872
46Synaptic vesicle cycle_Homo sapiens_hsa047211.02339274
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01387041
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99912861
49Cocaine addiction_Homo sapiens_hsa050300.99298713
50Estrogen signaling pathway_Homo sapiens_hsa049150.98440170
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.97669246
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97492944
53mTOR signaling pathway_Homo sapiens_hsa041500.96939231
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.95424184
55GABAergic synapse_Homo sapiens_hsa047270.94611406
56cAMP signaling pathway_Homo sapiens_hsa040240.94508712
57Dopaminergic synapse_Homo sapiens_hsa047280.94378596
58Fructose and mannose metabolism_Homo sapiens_hsa000510.94284072
59Long-term depression_Homo sapiens_hsa047300.93626701
60Notch signaling pathway_Homo sapiens_hsa043300.92948631
61Melanogenesis_Homo sapiens_hsa049160.92540859
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.91779678
63Oxytocin signaling pathway_Homo sapiens_hsa049210.91269523
64Toxoplasmosis_Homo sapiens_hsa051450.90639616
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90477554
66Wnt signaling pathway_Homo sapiens_hsa043100.90265147
67Inositol phosphate metabolism_Homo sapiens_hsa005620.89289362
68Chronic myeloid leukemia_Homo sapiens_hsa052200.88889118
69Axon guidance_Homo sapiens_hsa043600.88294610
70Influenza A_Homo sapiens_hsa051640.88274761
71Choline metabolism in cancer_Homo sapiens_hsa052310.87115611
72ABC transporters_Homo sapiens_hsa020100.85512454
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85341608
74Focal adhesion_Homo sapiens_hsa045100.84673885
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84216067
76Calcium signaling pathway_Homo sapiens_hsa040200.83581296
77Sphingolipid metabolism_Homo sapiens_hsa006000.82810671
78ECM-receptor interaction_Homo sapiens_hsa045120.82720284
79Basal cell carcinoma_Homo sapiens_hsa052170.82492172
80Vitamin digestion and absorption_Homo sapiens_hsa049770.82197667
81Hippo signaling pathway_Homo sapiens_hsa043900.82086708
82Proteoglycans in cancer_Homo sapiens_hsa052050.81598140
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80884155
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80251257
85VEGF signaling pathway_Homo sapiens_hsa043700.80192675
86Gap junction_Homo sapiens_hsa045400.79723942
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.79662460
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.79499382
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.78964917
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78841337
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77995206
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77456068
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77265078
94Serotonergic synapse_Homo sapiens_hsa047260.76486677
95Thyroid hormone synthesis_Homo sapiens_hsa049180.75982721
96MAPK signaling pathway_Homo sapiens_hsa040100.75129838
97Amoebiasis_Homo sapiens_hsa051460.75070957
98Prolactin signaling pathway_Homo sapiens_hsa049170.75026286
99Bile secretion_Homo sapiens_hsa049760.75012865
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74788417
101Hedgehog signaling pathway_Homo sapiens_hsa043400.74474577
102MicroRNAs in cancer_Homo sapiens_hsa052060.74356297
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73100828
104* Rap1 signaling pathway_Homo sapiens_hsa040150.72198399
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70984865
106Circadian rhythm_Homo sapiens_hsa047100.70131132
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69817660
108Tight junction_Homo sapiens_hsa045300.69747102
109Small cell lung cancer_Homo sapiens_hsa052220.69735281
110Hepatitis B_Homo sapiens_hsa051610.69359249
111Bladder cancer_Homo sapiens_hsa052190.68173708
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68042517
113TNF signaling pathway_Homo sapiens_hsa046680.67639604
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67498437
115Platelet activation_Homo sapiens_hsa046110.67040201
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.66804137
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.65903957
118Acute myeloid leukemia_Homo sapiens_hsa052210.65161043
119Dilated cardiomyopathy_Homo sapiens_hsa054140.64661551
120Lysine degradation_Homo sapiens_hsa003100.64479243
121Chemokine signaling pathway_Homo sapiens_hsa040620.64104038
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64101393
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63988553
124Colorectal cancer_Homo sapiens_hsa052100.62601768
125Non-small cell lung cancer_Homo sapiens_hsa052230.62295877
126Prostate cancer_Homo sapiens_hsa052150.61968125
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.61634901
128Type I diabetes mellitus_Homo sapiens_hsa049400.60849257
129Pancreatic cancer_Homo sapiens_hsa052120.60107830
130Renin-angiotensin system_Homo sapiens_hsa046140.60026160
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59023316
132HTLV-I infection_Homo sapiens_hsa051660.58194684
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.57900653
134Endocytosis_Homo sapiens_hsa041440.57176148
135FoxO signaling pathway_Homo sapiens_hsa040680.55591439
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54206081
137Pathways in cancer_Homo sapiens_hsa052000.53231138
138Apoptosis_Homo sapiens_hsa042100.48993487

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