SIPA1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.37997074
2synaptic vesicle maturation (GO:0016188)6.25973664
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.19811584
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.13212514
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.73320596
6vocalization behavior (GO:0071625)5.40748888
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.25895265
8synaptic vesicle exocytosis (GO:0016079)5.21005776
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.17185465
10regulation of glutamate receptor signaling pathway (GO:1900449)5.10215607
11glutamate secretion (GO:0014047)5.07896038
12regulation of long-term neuronal synaptic plasticity (GO:0048169)4.89669064
13regulation of neuronal synaptic plasticity (GO:0048168)4.81618653
14regulation of synaptic vesicle exocytosis (GO:2000300)4.69425555
15regulation of synapse structural plasticity (GO:0051823)4.68940851
16exploration behavior (GO:0035640)4.56236470
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.53989807
18dendritic spine morphogenesis (GO:0060997)4.41266530
19protein localization to synapse (GO:0035418)4.30574370
20layer formation in cerebral cortex (GO:0021819)4.20545977
21regulation of synaptic vesicle transport (GO:1902803)4.18525619
22G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.18265494
23neurotransmitter secretion (GO:0007269)4.15929851
24synaptic transmission, glutamatergic (GO:0035249)4.04892444
25neurotransmitter-gated ion channel clustering (GO:0072578)4.04234697
26long-term memory (GO:0007616)4.02120357
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.99422260
28neuronal action potential propagation (GO:0019227)3.97367270
29regulation of excitatory postsynaptic membrane potential (GO:0060079)3.95365528
30positive regulation of membrane potential (GO:0045838)3.93777704
31neuromuscular process controlling balance (GO:0050885)3.86896179
32glutamate receptor signaling pathway (GO:0007215)3.83350972
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.81124417
34* regulation of synaptic plasticity (GO:0048167)3.78697667
35neuron-neuron synaptic transmission (GO:0007270)3.75263220
36* regulation of dendritic spine morphogenesis (GO:0061001)3.71985631
37proline transport (GO:0015824)3.69753406
38regulation of postsynaptic membrane potential (GO:0060078)3.68931732
39cellular potassium ion homeostasis (GO:0030007)3.68415428
40sodium ion export (GO:0071436)3.67465533
41prepulse inhibition (GO:0060134)3.66609362
42activation of protein kinase A activity (GO:0034199)3.61410755
43positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.60533133
44amino acid import (GO:0043090)3.57201845
45positive regulation of synapse maturation (GO:0090129)3.55727759
46regulation of ARF protein signal transduction (GO:0032012)3.54046897
47long-term synaptic potentiation (GO:0060291)3.51714647
48negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.49870674
49positive regulation of neurotransmitter secretion (GO:0001956)3.46414019
50dendritic spine organization (GO:0097061)3.44874198
51positive regulation of neurotransmitter transport (GO:0051590)3.43072705
52gamma-aminobutyric acid transport (GO:0015812)3.37208717
53auditory behavior (GO:0031223)3.34568567
54detection of molecule of bacterial origin (GO:0032490)3.33304001
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30230275
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29492458
57protein localization to endosome (GO:0036010)3.27080546
58synaptic vesicle endocytosis (GO:0048488)3.27015432
59neuron cell-cell adhesion (GO:0007158)3.25769042
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.25498905
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.22034284
62positive regulation of dendritic spine morphogenesis (GO:0061003)3.20069254
63regulation of clathrin-mediated endocytosis (GO:2000369)3.19034539
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14988654
65response to auditory stimulus (GO:0010996)3.13441660
66behavioral defense response (GO:0002209)3.13255627
67behavioral fear response (GO:0001662)3.13255627
68neurotransmitter transport (GO:0006836)3.12341362
69regulation of neurotransmitter secretion (GO:0046928)3.11881519
70vesicle transport along microtubule (GO:0047496)3.11857606
71positive regulation of fibroblast migration (GO:0010763)3.11244099
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11117137
73positive regulation by symbiont of host defense response (GO:0052509)3.10834626
74modulation by symbiont of host defense response (GO:0052031)3.10834626
75modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.10834626
76modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.10834626
77positive regulation by organism of defense response of other organism involved in symbiotic interact3.10834626
78modulation by symbiont of host immune response (GO:0052553)3.10834626
79cerebellar Purkinje cell differentiation (GO:0021702)3.10670722
80response to histamine (GO:0034776)3.06130708
81chemosensory behavior (GO:0007635)3.05778300
82transmission of nerve impulse (GO:0019226)3.03658406
83neuronal ion channel clustering (GO:0045161)3.03365981
84membrane depolarization (GO:0051899)3.02312763
85positive regulation of dendritic spine development (GO:0060999)3.01377663
86signal complex assembly (GO:0007172)3.00497559
87* regulation of dendritic spine development (GO:0060998)3.00215940
88positive regulation of synaptic transmission (GO:0050806)2.99991094
89regulation of neurotransmitter levels (GO:0001505)2.99576755
90innervation (GO:0060384)2.99459706
91cytoskeletal anchoring at plasma membrane (GO:0007016)2.98145539
92long term synaptic depression (GO:0060292)2.98120753
93membrane hyperpolarization (GO:0060081)2.96985490
94neuromuscular process (GO:0050905)2.96646515
95regulation of vesicle fusion (GO:0031338)2.95866444
96cell communication by electrical coupling (GO:0010644)2.95478751
97learning (GO:0007612)2.95115496
98regulation of neurotransmitter transport (GO:0051588)2.95000837
99establishment of nucleus localization (GO:0040023)2.92710448
100glycine transport (GO:0015816)2.92297523
101visual learning (GO:0008542)2.91729126
102macrophage activation involved in immune response (GO:0002281)2.91351288
103L-amino acid import (GO:0043092)2.87992657
104dendrite morphogenesis (GO:0048813)2.87916598
105membrane depolarization during action potential (GO:0086010)2.86016873
106dopamine receptor signaling pathway (GO:0007212)2.85892797
107positive regulation of vesicle fusion (GO:0031340)2.85120888
108striatum development (GO:0021756)2.84941128
109regulation of female receptivity (GO:0045924)2.84390123
110fear response (GO:0042596)2.83731562
111negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82045316
112* regulation of synaptic transmission (GO:0050804)2.81995304
113negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.78408261
114negative regulation of cell killing (GO:0031342)2.78408261
115regulation of B cell receptor signaling pathway (GO:0050855)2.72892198
116histone H3-K36 demethylation (GO:0070544)2.72748091
117regulation of T-helper 2 cell differentiation (GO:0045628)2.64455516
118positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.61040056
119regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.60473071
120regulation of beta-amyloid formation (GO:1902003)2.54611106
121response to host (GO:0075136)2.54239827
122response to host defenses (GO:0052200)2.54239827
123response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.54239827
124negative regulation of toll-like receptor signaling pathway (GO:0034122)2.48943336
125response to muramyl dipeptide (GO:0032495)2.47827938
126positive regulation of cellular amide metabolic process (GO:0034250)2.47449780
127negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.46582744
128hypotonic response (GO:0006971)2.46274531
129skin morphogenesis (GO:0043589)2.44708358
130regulation of amyloid precursor protein catabolic process (GO:1902991)2.42322830
131negative regulation of dendrite morphogenesis (GO:0050774)2.37436923
132regulation of cellular amide metabolic process (GO:0034248)2.36721968
133phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.35998207
134regulation of Rac protein signal transduction (GO:0035020)2.34261604
135germinal center formation (GO:0002467)2.33088792
136negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.33029574
137focal adhesion assembly (GO:0048041)2.32812483
138cell-substrate adherens junction assembly (GO:0007045)2.32812483
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.32124370
140response to host immune response (GO:0052572)2.32124370
141negative regulation of osteoblast proliferation (GO:0033689)2.29462308
142negative regulation of T-helper cell differentiation (GO:0045623)2.27271976
143negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.27271976
144regulation of interferon-beta biosynthetic process (GO:0045357)2.26587598
145detection of external biotic stimulus (GO:0098581)2.22492125
146positive regulation of macrophage cytokine production (GO:0060907)2.22444063
147regulation of protein polyubiquitination (GO:1902914)2.22127607
148activation of Rac GTPase activity (GO:0032863)2.21350096
149adherens junction assembly (GO:0034333)2.21150658
150antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.20302702
151positive regulation of type 2 immune response (GO:0002830)2.19965987
152regulation of macrophage cytokine production (GO:0010935)2.19393605
153cortical actin cytoskeleton organization (GO:0030866)2.19232806
154insulin-like growth factor receptor signaling pathway (GO:0048009)2.18464928
155cell-substrate junction assembly (GO:0007044)2.16859287
156production of molecular mediator involved in inflammatory response (GO:0002532)2.15290944
157* positive regulation of Rap GTPase activity (GO:0032854)2.13888446
158peptidyl-threonine phosphorylation (GO:0018107)2.12469077
159platelet-derived growth factor receptor signaling pathway (GO:0048008)2.08886887
160stress fiber assembly (GO:0043149)2.08340070
161response to peptidoglycan (GO:0032494)2.06901873
162positive regulation of Cdc42 GTPase activity (GO:0043089)2.06841323
163regulation of ARF GTPase activity (GO:0032312)2.06762782
164cellular response to interleukin-15 (GO:0071350)2.06043443
165response to interleukin-15 (GO:0070672)2.05731980
166pericardium development (GO:0060039)2.05555697
167peptidyl-threonine modification (GO:0018210)2.05275189
168cortical cytoskeleton organization (GO:0030865)2.04902873
169import into cell (GO:0098657)2.01991483
170macrophage activation (GO:0042116)2.01852081
171detection of other organism (GO:0098543)2.01457019
172response to laminar fluid shear stress (GO:0034616)2.00337036
173negative regulation of interleukin-12 production (GO:0032695)2.00327022
174regulation of NFAT protein import into nucleus (GO:0051532)1.99751828
175B cell receptor signaling pathway (GO:0050853)1.99326391
176cellular response to ethanol (GO:0071361)1.99089061
177positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)1.97778868
178establishment of endothelial barrier (GO:0061028)1.95743077
179cerebellar granule cell differentiation (GO:0021707)1.95389146
180positive regulation of gamma-delta T cell activation (GO:0046645)1.95313448
181positive regulation of receptor recycling (GO:0001921)1.95025951
182NLS-bearing protein import into nucleus (GO:0006607)1.94972436
183cell adhesion mediated by integrin (GO:0033627)1.94888815
184* regulation of Rap GTPase activity (GO:0032317)1.94755724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.45370973
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61094143
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.24632497
4DROSHA_22980978_ChIP-Seq_HELA_Human2.89381989
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.81055978
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79123732
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76906745
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64272436
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64272436
10GBX2_23144817_ChIP-Seq_PC3_Human2.60757275
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.57354747
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42872813
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40344266
14* REST_21632747_ChIP-Seq_MESCs_Mouse2.38161785
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37400742
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.32602394
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30670151
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29813318
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22464195
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19333303
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18227324
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13912509
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.13556880
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.07373467
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06406334
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.96755286
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.96638596
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96023509
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.92833264
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.89576770
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79085810
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.78186541
33* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74439510
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73120904
35AR_21572438_ChIP-Seq_LNCaP_Human1.71492802
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.70225410
37KDM2B_26808549_Chip-Seq_K562_Human1.62469113
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62463286
39* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59800096
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57758390
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55066920
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54759671
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.53108045
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50875176
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.49686514
46RUNX_20019798_ChIP-Seq_JUKART_Human1.49005524
47* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.46796947
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46521149
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.46148106
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.45347795
51EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45317906
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44965421
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44922988
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44328655
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44285122
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43437922
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.42567607
58* EP300_21415370_ChIP-Seq_HL-1_Mouse1.42178276
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.40821130
60* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39875533
61VDR_24787735_ChIP-Seq_THP-1_Human1.39661685
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39565680
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38956697
64SMAD4_21799915_ChIP-Seq_A2780_Human1.37532629
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36754924
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36156493
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35400500
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33011366
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.32759255
70AR_19668381_ChIP-Seq_PC3_Human1.30712246
71* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30538924
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28655178
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.27792864
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.26701893
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23738117
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23650731
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.22250382
78* TCF7_22412390_ChIP-Seq_EML_Mouse1.22185868
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.20936893
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19523181
81* BRD4_25478319_ChIP-Seq_HGPS_Human1.18750364
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17641485
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17641485
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14289836
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14151978
86KDM2B_26808549_Chip-Seq_DND41_Human1.14119184
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.13824006
88AHR_22903824_ChIP-Seq_MCF-7_Human1.13584688
89* TP53_16413492_ChIP-PET_HCT116_Human1.12980733
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12938824
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.12762697
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.12281125
93SPI1_23127762_ChIP-Seq_K562_Human1.11703879
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.10912364
95STAT3_23295773_ChIP-Seq_U87_Human1.09822983
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09791822
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09743527
98* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09326659
99* SMAD3_21741376_ChIP-Seq_HESCs_Human1.09035690
100* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08481904
101TRIM28_21343339_ChIP-Seq_HEK293_Human1.08157334
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08053669
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07385039
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06828001
105RXR_22108803_ChIP-Seq_LS180_Human1.06681554
106CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06025133
107STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04449553
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04255879
109PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02286681
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.02213145
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02104165
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00751184
113* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00578845
114AR_25329375_ChIP-Seq_VCAP_Human1.00261572
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99736288
116TP63_23658742_ChIP-Seq_EP156T_Human0.99573869
117* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98866667
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98802372
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98781855
120CJUN_26792858_Chip-Seq_BT549_Human0.98194034
121* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97236493
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97028258
123ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96978275
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96639146
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96418698
126* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96187521
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.94639938
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94159570
129* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94136290
130* TCF4_23295773_ChIP-Seq_U87_Human0.94027785
131PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93694729
132STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92510523
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92443926
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91415164
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91288774
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90055365
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89539946
138ZNF274_21170338_ChIP-Seq_K562_Hela0.89373899
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88898540
140GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87763839
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87107448
142* TET1_21490601_ChIP-Seq_MESCs_Mouse0.86939410
143TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86878759
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86609588
145* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86414925
146* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85129120
147PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85057538
148LXR_22292898_ChIP-Seq_THP-1_Human0.84668748
149PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84266306
150KLF4_19829295_ChIP-Seq_ESCs_Human0.84036586
151IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83961738
152P300_19829295_ChIP-Seq_ESCs_Human0.83818043
153CTCF_27219007_Chip-Seq_Bcells_Human0.83640203
154TP53_18474530_ChIP-ChIP_U2OS_Human0.82924906
155ESR1_20079471_ChIP-ChIP_T-47D_Human0.82748100
156E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82081185
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81849470
158CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80194352
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79478552
160ESR2_21235772_ChIP-Seq_MCF-7_Human0.78959225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity8.19912748
2MP0002822_catalepsy4.66436089
3MP0003635_abnormal_synaptic_transmissio4.44957563
4MP0003880_abnormal_central_pattern4.27981821
5MP0004270_analgesia3.63026168
6MP0002063_abnormal_learning/memory/cond3.62923060
7MP0009745_abnormal_behavioral_response3.54331724
8MP0002064_seizures3.15890431
9MP0009046_muscle_twitch2.82919815
10MP0002572_abnormal_emotion/affect_behav2.80508576
11MP0010352_gastrointestinal_tract_polyps2.71054267
12MP0008438_abnormal_cutaneous_collagen2.65682928
13MP0001486_abnormal_startle_reflex2.61947849
14MP0009780_abnormal_chondrocyte_physiolo2.58874194
15MP0001968_abnormal_touch/_nociception2.52045372
16MP0003566_abnormal_cell_adhesion2.50009639
17MP0001958_emphysema2.48717587
18MP0002272_abnormal_nervous_system2.31031448
19MP0001501_abnormal_sleep_pattern2.23042385
20MP0001348_abnormal_lacrimal_gland2.18816226
21MP0005423_abnormal_somatic_nervous2.16781856
22MP0003436_decreased_susceptibility_to2.13181808
23MP0003879_abnormal_hair_cell2.10909978
24MP0002734_abnormal_mechanical_nocicepti2.10449139
25MP0008260_abnormal_autophagy2.08219942
26MP0004858_abnormal_nervous_system2.03187078
27MP0000685_abnormal_immune_system1.97127541
28MP0008569_lethality_at_weaning1.96611817
29MP0000569_abnormal_digit_pigmentation1.92401068
30MP0002909_abnormal_adrenal_gland1.90496261
31MP0004811_abnormal_neuron_physiology1.87750060
32MP0010234_abnormal_vibrissa_follicle1.80131735
33MP0003787_abnormal_imprinting1.71454624
34MP0002736_abnormal_nociception_after1.69383474
35MP0005387_immune_system_phenotype1.68280791
36MP0001790_abnormal_immune_system1.68280791
37MP0004947_skin_inflammation1.68102532
38MP0008961_abnormal_basal_metabolism1.67449247
39MP0001440_abnormal_grooming_behavior1.65553848
40MP0005275_abnormal_skin_tensile1.65181927
41MP0001835_abnormal_antigen_presentation1.64939268
42MP0001970_abnormal_pain_threshold1.61216980
43MP0002733_abnormal_thermal_nociception1.60039170
44MP0003329_amyloid_beta_deposits1.58004237
45MP0005386_behavior/neurological_phenoty1.57185327
46MP0004924_abnormal_behavior1.57185327
47MP0002557_abnormal_social/conspecific_i1.56150810
48MP0005023_abnormal_wound_healing1.55385894
49MP0008057_abnormal_DNA_replication1.55303979
50MP0003183_abnormal_peptide_metabolism1.53779998
51MP0002168_other_aberrant_phenotype1.51843130
52MP0002067_abnormal_sensory_capabilities1.51717889
53MP0002735_abnormal_chemical_nociception1.48938436
54MP0003075_altered_response_to1.48327881
55MP0005646_abnormal_pituitary_gland1.48211696
56MP0000920_abnormal_myelination1.46705634
57MP0003191_abnormal_cellular_cholesterol1.45980414
58MP0001849_ear_inflammation1.45240530
59MP0004885_abnormal_endolymph1.44852971
60MP0005000_abnormal_immune_tolerance1.42506417
61MP0002184_abnormal_innervation1.39321969
62MP0003633_abnormal_nervous_system1.38168506
63MP0002254_reproductive_system_inflammat1.37655011
64MP0001800_abnormal_humoral_immune1.33936888
65MP0000778_abnormal_nervous_system1.32208607
66MP0000955_abnormal_spinal_cord1.31755197
67MP0002998_abnormal_bone_remodeling1.31183618
68MP0002133_abnormal_respiratory_system1.31091044
69MP0005388_respiratory_system_phenotype1.31091044
70MP0003724_increased_susceptibility_to1.30560276
71MP0002066_abnormal_motor_capabilities/c1.26566420
72MP0003279_aneurysm1.25847665
73MP0006082_CNS_inflammation1.22438541
74MP0003763_abnormal_thymus_physiology1.21419278
75MP0005621_abnormal_cell_physiology1.21188961
76MP0002419_abnormal_innate_immunity1.20515711
77MP0008874_decreased_physiological_sensi1.20277212
78MP0002882_abnormal_neuron_morphology1.19008413
79MP0001533_abnormal_skeleton_physiology1.17753265
80MP0003890_abnormal_embryonic-extraembry1.16868585
81MP0003283_abnormal_digestive_organ1.16755992
82MP0001177_atelectasis1.16103354
83MP0003453_abnormal_keratinocyte_physiol1.14252247
84MP0008872_abnormal_physiological_respon1.13658758
85MP0005623_abnormal_meninges_morphology1.12543099
86MP0005164_abnormal_response_to1.11467523
87MP0004883_abnormal_blood_vessel1.11162387
88MP0003448_altered_tumor_morphology1.10887168
89MP0005451_abnormal_body_composition1.10742296
90MP0003631_nervous_system_phenotype1.10347442
91MP0001851_eye_inflammation1.09722479
92MP0002452_abnormal_antigen_presenting1.06573430
93MP0002723_abnormal_immune_serum1.05802368
94MP0002152_abnormal_brain_morphology1.05612524
95MP0005167_abnormal_blood-brain_barrier1.05596600
96MP0002006_tumorigenesis1.03045388
97MP0010678_abnormal_skin_adnexa1.02092313
98MP0003045_fibrosis1.01989941
99MP0000767_abnormal_smooth_muscle1.01936626
100MP0004510_myositis1.01872263
101MP0001984_abnormal_olfaction1.00766542
102MP0000383_abnormal_hair_follicle0.98753643
103MP0002060_abnormal_skin_morphology0.96780273
104MP0002405_respiratory_system_inflammati0.94789091
105MP0002069_abnormal_eating/drinking_beha0.94662041
106MP0002420_abnormal_adaptive_immunity0.94346797
107MP0001819_abnormal_immune_cell0.93427025
108MP0001853_heart_inflammation0.92599176
109MP0006054_spinal_hemorrhage0.90342210
110MP0000013_abnormal_adipose_tissue0.86111947
111MP0002896_abnormal_bone_mineralization0.86062661
112MP0001502_abnormal_circadian_rhythm0.85004985
113MP0000428_abnormal_craniofacial_morphol0.84943428
114MP0003950_abnormal_plasma_membrane0.84286767
115MP0005025_abnormal_response_to0.84086591
116MP0001915_intracranial_hemorrhage0.81524873
117MP0004264_abnormal_extraembryonic_tissu0.81198312
118MP0003941_abnormal_skin_development0.81034400
119MP0005257_abnormal_intraocular_pressure0.78753204
120MP0008877_abnormal_DNA_methylation0.77209754
121MP0001529_abnormal_vocalization0.76433190
122MP0005645_abnormal_hypothalamus_physiol0.74510818
123MP0005535_abnormal_body_temperature0.74330240
124MP0000427_abnormal_hair_cycle0.74082859
125MP0003172_abnormal_lysosome_physiology0.73761793
126MP0001485_abnormal_pinna_reflex0.72634204
127MP0002166_altered_tumor_susceptibility0.72318278
128MP0003868_abnormal_feces_composition0.72302351
129MP0004233_abnormal_muscle_weight0.72291213
130MP0004085_abnormal_heartbeat0.71584478
131MP0003303_peritoneal_inflammation0.70349563
132MP0003690_abnormal_glial_cell0.69479253
133MP0003632_abnormal_nervous_system0.68078456
134MP0000604_amyloidosis0.68021062
135MP0000751_myopathy0.67252948
136MP0005394_taste/olfaction_phenotype0.65953925
137MP0005499_abnormal_olfactory_system0.65953925
138MP0005166_decreased_susceptibility_to0.64703966
139MP0002090_abnormal_vision0.64478089
140MP0003122_maternal_imprinting0.63690191
141MP0005076_abnormal_cell_differentiation0.59593605
142MP0001963_abnormal_hearing_physiology0.59559554
143MP0003300_gastrointestinal_ulcer0.58961051
144MP0002089_abnormal_postnatal_growth/wei0.58577204
145MP0003861_abnormal_nervous_system0.57123017
146MP0005409_darkened_coat_color0.55440803
147MP0004484_altered_response_of0.54687927
148MP0002229_neurodegeneration0.54238002
149MP0003705_abnormal_hypodermis_morpholog0.53212471
150MP0010769_abnormal_survival0.53044053
151MP0000534_abnormal_ureter_morphology0.51784779
152MP0001765_abnormal_ion_homeostasis0.51664163
153MP0001943_abnormal_respiration0.51448504
154MP0003091_abnormal_cell_migration0.50510947
155MP0005310_abnormal_salivary_gland0.50294641
156MP0003634_abnormal_glial_cell0.49939537
157MP0001188_hyperpigmentation0.49754279
158MP0001299_abnormal_eye_distance/0.49531820
159MP0000003_abnormal_adipose_tissue0.49512836
160MP0004130_abnormal_muscle_cell0.48862091
161MP0010768_mortality/aging0.48859052
162MP0010770_preweaning_lethality0.47746611
163MP0002082_postnatal_lethality0.47746611
164MP0003123_paternal_imprinting0.47356513

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.19266406
2Myokymia (HP:0002411)7.15863774
3Focal seizures (HP:0007359)5.46960466
4Visual hallucinations (HP:0002367)4.43607385
5Epileptic encephalopathy (HP:0200134)4.12041821
6Action tremor (HP:0002345)3.79596700
7Febrile seizures (HP:0002373)3.60598119
8Atonic seizures (HP:0010819)3.59129283
9Impaired vibration sensation in the lower limbs (HP:0002166)3.58860103
10Poor eye contact (HP:0000817)3.50010068
11Absence seizures (HP:0002121)3.47700906
12Annular pancreas (HP:0001734)3.46335169
13Progressive cerebellar ataxia (HP:0002073)3.41435931
14Abnormality of the lower motor neuron (HP:0002366)3.37406703
15Urinary bladder sphincter dysfunction (HP:0002839)3.30056386
16Impaired social interactions (HP:0000735)3.29144106
17Abnormal social behavior (HP:0012433)3.29144106
18Generalized tonic-clonic seizures (HP:0002069)3.26565284
19Papilledema (HP:0001085)3.22013699
20Broad-based gait (HP:0002136)3.15097279
21Gaze-evoked nystagmus (HP:0000640)3.13613822
22Depression (HP:0000716)3.12780569
23Dysmetric saccades (HP:0000641)3.11760312
24Dialeptic seizures (HP:0011146)3.10891415
25Arterial tortuosity (HP:0005116)3.08468376
26Dysdiadochokinesis (HP:0002075)3.05552616
27Papillary thyroid carcinoma (HP:0002895)2.99569393
28Impaired smooth pursuit (HP:0007772)2.97140728
29Pointed chin (HP:0000307)2.96046285
30Genetic anticipation (HP:0003743)2.94494966
31Postural instability (HP:0002172)2.94233374
32Vascular tortuosity (HP:0004948)2.91369796
33Ankle clonus (HP:0011448)2.88236987
34Urinary urgency (HP:0000012)2.85054321
35Ankyloglossia (HP:0010296)2.83818950
36Dysmetria (HP:0001310)2.82699385
37Stereotypic behavior (HP:0000733)2.75335633
38Torticollis (HP:0000473)2.72006912
39Hemiplegia (HP:0002301)2.71859162
40Amblyopia (HP:0000646)2.71768671
41Supranuclear gaze palsy (HP:0000605)2.68001498
42Resting tremor (HP:0002322)2.67474576
43Neurofibrillary tangles (HP:0002185)2.59714631
44Truncal ataxia (HP:0002078)2.58473750
45Abnormality of ocular smooth pursuit (HP:0000617)2.56519041
46Anxiety (HP:0000739)2.54409181
47Peritonitis (HP:0002586)2.52136439
48Focal dystonia (HP:0004373)2.49456613
49Vertebral arch anomaly (HP:0008438)2.48411321
50Aortic dissection (HP:0002647)2.45665215
51Impaired vibratory sensation (HP:0002495)2.44076264
52Obstructive sleep apnea (HP:0002870)2.42642081
53Protrusio acetabuli (HP:0003179)2.42362431
54Premature rupture of membranes (HP:0001788)2.38328457
55Lower limb amyotrophy (HP:0007210)2.38306886
56Abnormal eating behavior (HP:0100738)2.36782681
57Intention tremor (HP:0002080)2.34547122
58Megalencephaly (HP:0001355)2.33876624
59Hyperventilation (HP:0002883)2.32019583
60Orchitis (HP:0100796)2.28185294
61Abnormality of oral frenula (HP:0000190)2.25977053
62Aortic aneurysm (HP:0004942)2.25911225
63Overgrowth (HP:0001548)2.25887197
64Spondylolisthesis (HP:0003302)2.24445876
65Scanning speech (HP:0002168)2.23785211
66Bradykinesia (HP:0002067)2.23374050
67Excessive salivation (HP:0003781)2.21181952
68Drooling (HP:0002307)2.21181952
69Subacute progressive viral hepatitis (HP:0006572)2.20426527
70Ventricular fibrillation (HP:0001663)2.19621485
71Recurrent abscess formation (HP:0002722)2.18595720
72Lower limb asymmetry (HP:0100559)2.17884352
73Macroorchidism (HP:0000053)2.13334461
74Craniofacial dystonia (HP:0012179)2.12656445
75Optic neuritis (HP:0100653)2.12604698
76Retrobulbar optic neuritis (HP:0100654)2.12604698
77Insomnia (HP:0100785)2.11590195
78Spastic gait (HP:0002064)2.07713640
79Mutism (HP:0002300)2.07270155
80Atrophic scars (HP:0001075)2.07247235
81Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07172165
82Termporal pattern (HP:0011008)2.06248395
83Insidious onset (HP:0003587)2.06248395
84Bundle branch block (HP:0011710)2.05890985
85Abnormality of incisor morphology (HP:0011063)2.04150692
86Dilatation of the ascending aorta (HP:0005111)2.03605663
87Slow saccadic eye movements (HP:0000514)2.03284538
88Status epilepticus (HP:0002133)2.01587400
89Shallow orbits (HP:0000586)2.01509881
90Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.01376252
91Genu recurvatum (HP:0002816)2.01211621
92Epileptiform EEG discharges (HP:0011182)2.00273841
93Abnormality of binocular vision (HP:0011514)2.00069018
94Diplopia (HP:0000651)2.00069018
95Broad metatarsal (HP:0001783)1.98122690
96Mitral stenosis (HP:0001718)1.96817943
97Arnold-Chiari malformation (HP:0002308)1.95761007
98Distal upper limb amyotrophy (HP:0007149)1.94635816
99Upper limb amyotrophy (HP:0009129)1.94635816
100Narrow palate (HP:0000189)1.94363693
101Deep palmar crease (HP:0006191)1.94008893
102Hemiparesis (HP:0001269)1.93840573
103Eczematoid dermatitis (HP:0000976)1.93518196
104Obsessive-compulsive behavior (HP:0000722)1.91584731
105Mitral valve prolapse (HP:0001634)1.89884301
106Intellectual disability, profound (HP:0002187)1.89799275
107Myositis (HP:0100614)1.89669047
108Abnormality of the fingertips (HP:0001211)1.89582736
109EEG with generalized epileptiform discharges (HP:0011198)1.87383415
110Mitral regurgitation (HP:0001653)1.85212729
111Recurrent bacterial skin infections (HP:0005406)1.84255072
112Incomplete penetrance (HP:0003829)1.82149314
113Dislocated radial head (HP:0003083)1.82092265
114Cerebral inclusion bodies (HP:0100314)1.81562931
115Absent speech (HP:0001344)1.81013925
116Hypsarrhythmia (HP:0002521)1.80481569
117Gingivitis (HP:0000230)1.80400952
118Hyperacusis (HP:0010780)1.80290127
119Lower limb muscle weakness (HP:0007340)1.79413536
120Spinal cord lesions (HP:0100561)1.79055986
121Syringomyelia (HP:0003396)1.79055986
122Urethral obstruction (HP:0000796)1.78119811
123Abnormality of the periventricular white matter (HP:0002518)1.77931934
124Inappropriate behavior (HP:0000719)1.76662837
125Achilles tendon contracture (HP:0001771)1.76280391
126Mild short stature (HP:0003502)1.76218388
127Deeply set eye (HP:0000490)1.75449495
128Cubitus valgus (HP:0002967)1.75174490
129Neonatal short-limb short stature (HP:0008921)1.74740456
130Hand muscle atrophy (HP:0009130)1.71881926
131Polygenic inheritance (HP:0010982)1.71758357
132Neoplasm of the heart (HP:0100544)1.71075664
133Apathy (HP:0000741)1.68838654
134Neuronal loss in central nervous system (HP:0002529)1.68546605
135Fragile skin (HP:0001030)1.67815808
136Gait ataxia (HP:0002066)1.67376976
137Bowel diverticulosis (HP:0005222)1.66758397
138Bladder diverticulum (HP:0000015)1.66150027
139Decreased motor nerve conduction velocity (HP:0003431)1.65420818
140Abnormality of saccadic eye movements (HP:0000570)1.65313935
141Cerebral aneurysm (HP:0004944)1.65257559
142Progressive inability to walk (HP:0002505)1.63940255
143Generalized myoclonic seizures (HP:0002123)1.63426477
144Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.62290270
145Autism (HP:0000717)1.62150257
146Spinal canal stenosis (HP:0003416)1.62059537
147Fetal akinesia sequence (HP:0001989)1.61456690
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.61420902
149Osteolytic defects of the hand bones (HP:0009699)1.61420902
150Renovascular hypertension (HP:0100817)1.61238088
151Cervical subluxation (HP:0003308)1.59987392
152Gastrointestinal infarctions (HP:0005244)1.59468679
153Aneurysm (HP:0002617)1.58586996
154Abnormality of the radial head (HP:0003995)1.58057094
155Absent frontal sinuses (HP:0002688)1.57812932
156Generalized hypotonia (HP:0001290)1.57808279
157Spinal cord compression (HP:0002176)1.57727648
158Relative macrocephaly (HP:0004482)1.57381016
159Deep philtrum (HP:0002002)1.57351614
160Wormian bones (HP:0002645)1.56129339
161Abnormality of the frontal sinuses (HP:0002687)1.55687093
162IgA deficiency (HP:0002720)1.55652389
163Emphysema (HP:0002097)1.54883080
164Bronchomalacia (HP:0002780)1.54488020
165Hyperextensible skin (HP:0000974)1.54165446
166Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.52855386
167Ankle contracture (HP:0006466)1.52765773
168Menstrual irregularities (HP:0000858)1.51731159
169Gastrointestinal stroma tumor (HP:0100723)1.51414969
170Flat cornea (HP:0007720)1.50938024
171Cellulitis (HP:0100658)1.49611206
172Long palpebral fissure (HP:0000637)1.49052140
173Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.47673572
174Long eyelashes (HP:0000527)1.47374768
175Vasculitis (HP:0002633)1.47353940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.61655526
2NTRK34.29069191
3MAP3K94.11932479
4PRKD33.12946527
5DAPK23.00246955
6KSR22.72796507
7MAP3K42.54324326
8PAK62.31912261
9RIPK42.28621496
10MINK12.22466238
11CAMKK12.17259847
12NEK92.07042945
13CAMK1D2.04513734
14DAPK11.88144739
15JAK11.87854675
16MAP3K131.86936528
17KSR11.82983953
18ERN11.81814910
19TAOK11.76551360
20NTRK21.73992448
21STK381.73367396
22TYRO31.66458393
23NTRK11.65180408
24SIK21.63964707
25BRD41.53353427
26MELK1.52063574
27MAP2K41.48963631
28MAP2K71.47146961
29FES1.45464574
30MAP3K21.44471620
31FGFR41.41976380
32* CDK51.39879072
33MARK11.39757183
34EPHB11.31825711
35MAP3K141.30243190
36RIPK11.28036030
37AKT31.27924527
38PRPF4B1.25576935
39NEK61.24954116
40RAF11.23997671
41TYK21.18663101
42FGFR31.16551998
43ALK1.12258573
44ARAF1.11730634
45IKBKE1.11017859
46CSK1.09759871
47PTK21.08807396
48PTK2B1.07096280
49SMG11.06872821
50PRKCH1.06868640
51DDR21.05702868
52RET1.04161629
53STK241.03958539
54STK111.02468705
55DMPK1.02451543
56SIK11.01454919
57TRIB31.00819154
58CAMK11.00177499
59JAK30.99023623
60LATS20.97680828
61IRAK40.97199493
62PLK20.95272330
63ROCK20.94549139
64PDK10.94174183
65SGK30.93905036
66YES10.92841269
67MAP3K70.92060547
68MAP3K30.89846299
69BLK0.87947501
70JAK20.87216631
71PRKCG0.85782093
72MARK20.83128344
73PDPK10.80776731
74SGK10.80251251
75MAP3K120.80038242
76CAMK1G0.78520557
77CDK190.78225102
78STK38L0.78209419
79SGK20.77627264
80MET0.75440913
81CDK150.75348868
82CDK180.74477518
83GRK50.74318568
84PDGFRA0.72933107
85STK100.71979103
86UHMK10.70623544
87MAP3K10.70172912
88MAPK70.69339810
89MTOR0.69236658
90SGK2230.67404424
91SGK4940.67404424
92CDK140.66427130
93CAMKK20.65398739
94CAMK2A0.64890300
95HCK0.64852227
96PRKD20.64519009
97BMX0.64462559
98TNK20.64458987
99BMPR20.64430521
100CDK11A0.64372129
101PAK30.63036463
102CAMK40.62614221
103CHUK0.62396753
104TNIK0.62106408
105MAP4K10.58132317
106IRAK20.57369281
107CDC42BPA0.55745765
108RPS6KA30.55098457
109LMTK20.54627413
110MAPK130.53346658
111SCYL20.53221755
112TRPM70.51512521
113PKN20.51302245
114PNCK0.51147774
115SIK30.50749219
116MAPK100.49337377
117ZAP700.48690628
118FYN0.48564992
119NEK10.48367617
120CAMK2B0.45836555
121DAPK30.45245221
122LRRK20.45085344
123ROCK10.44365041
124MAP2K10.44303516
125NLK0.44289542
126CDK120.42366032
127PRKCZ0.41857428
128ICK0.41445598
129BRSK10.40188792
130EEF2K0.39070024
131WNK10.38733560
132PINK10.38493500
133FER0.37975980
134MOS0.37183610
135FGR0.36586334
136MAP3K60.36268678
137PDGFRB0.34932924
138FGFR20.33276760
139DYRK1A0.32837624
140PRKCB0.31699838
141MAPK80.29578975

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.75871385
2Olfactory transduction_Homo sapiens_hsa047402.74179125
3Long-term potentiation_Homo sapiens_hsa047202.70643473
4Synaptic vesicle cycle_Homo sapiens_hsa047212.53782234
5Circadian entrainment_Homo sapiens_hsa047132.47111629
6Amphetamine addiction_Homo sapiens_hsa050312.36530899
7Glutamatergic synapse_Homo sapiens_hsa047242.29494008
8Morphine addiction_Homo sapiens_hsa050322.19572245
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17107792
10GABAergic synapse_Homo sapiens_hsa047272.15920683
11Salivary secretion_Homo sapiens_hsa049702.07637153
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03960155
13Dopaminergic synapse_Homo sapiens_hsa047281.98919078
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91321089
15Gastric acid secretion_Homo sapiens_hsa049711.90220310
16Cholinergic synapse_Homo sapiens_hsa047251.85401885
17Insulin secretion_Homo sapiens_hsa049111.79623557
18Oxytocin signaling pathway_Homo sapiens_hsa049211.70993675
19Nitrogen metabolism_Homo sapiens_hsa009101.66428980
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64073896
21Renin secretion_Homo sapiens_hsa049241.61799838
22B cell receptor signaling pathway_Homo sapiens_hsa046621.55838464
23GnRH signaling pathway_Homo sapiens_hsa049121.55809936
24Cocaine addiction_Homo sapiens_hsa050301.55154232
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54884483
26Glioma_Homo sapiens_hsa052141.54338327
27Long-term depression_Homo sapiens_hsa047301.51805129
28Calcium signaling pathway_Homo sapiens_hsa040201.47719609
29Osteoclast differentiation_Homo sapiens_hsa043801.41337641
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37591557
31Gap junction_Homo sapiens_hsa045401.31790471
32Type II diabetes mellitus_Homo sapiens_hsa049301.31493078
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30353941
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29120779
35cAMP signaling pathway_Homo sapiens_hsa040241.28722070
36Estrogen signaling pathway_Homo sapiens_hsa049151.25850727
37ErbB signaling pathway_Homo sapiens_hsa040121.20649560
38Taste transduction_Homo sapiens_hsa047421.18568707
39Serotonergic synapse_Homo sapiens_hsa047261.18379713
40Leishmaniasis_Homo sapiens_hsa051401.16462442
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15210011
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13535665
43TNF signaling pathway_Homo sapiens_hsa046681.12033754
44Melanogenesis_Homo sapiens_hsa049161.11024320
45Adherens junction_Homo sapiens_hsa045201.09983704
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09852767
47Dorso-ventral axis formation_Homo sapiens_hsa043201.09719515
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.09385222
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08082095
50Pancreatic cancer_Homo sapiens_hsa052121.08077522
51Amoebiasis_Homo sapiens_hsa051461.07151164
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06232878
53Toxoplasmosis_Homo sapiens_hsa051451.05225997
54Measles_Homo sapiens_hsa051621.04996029
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03716293
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.02930165
57Tuberculosis_Homo sapiens_hsa051521.02721034
58Phospholipase D signaling pathway_Homo sapiens_hsa040721.01366803
59mTOR signaling pathway_Homo sapiens_hsa041500.97539607
60VEGF signaling pathway_Homo sapiens_hsa043700.96922580
61Influenza A_Homo sapiens_hsa051640.96732391
62Prostate cancer_Homo sapiens_hsa052150.96631231
63Non-small cell lung cancer_Homo sapiens_hsa052230.95651777
64Hepatitis B_Homo sapiens_hsa051610.95518715
65Hepatitis C_Homo sapiens_hsa051600.95503372
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.92655563
67Acute myeloid leukemia_Homo sapiens_hsa052210.92473642
68Oocyte meiosis_Homo sapiens_hsa041140.91751737
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90420563
70Choline metabolism in cancer_Homo sapiens_hsa052310.90303602
71MicroRNAs in cancer_Homo sapiens_hsa052060.90262377
72Axon guidance_Homo sapiens_hsa043600.89483364
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.89103683
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88599408
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87514257
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84828381
77Thyroid hormone synthesis_Homo sapiens_hsa049180.83015395
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.81929766
79Notch signaling pathway_Homo sapiens_hsa043300.81303385
80MAPK signaling pathway_Homo sapiens_hsa040100.80580443
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80247788
82* Rap1 signaling pathway_Homo sapiens_hsa040150.78770271
83Dilated cardiomyopathy_Homo sapiens_hsa054140.78456817
84Endometrial cancer_Homo sapiens_hsa052130.75041583
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74863467
86Small cell lung cancer_Homo sapiens_hsa052220.74499338
87Malaria_Homo sapiens_hsa051440.74204824
88FoxO signaling pathway_Homo sapiens_hsa040680.73919065
89Pancreatic secretion_Homo sapiens_hsa049720.71756813
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71435102
91Glucagon signaling pathway_Homo sapiens_hsa049220.67903302
92Apoptosis_Homo sapiens_hsa042100.67848274
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63962808
94Allograft rejection_Homo sapiens_hsa053300.63767677
95Ras signaling pathway_Homo sapiens_hsa040140.62699732
96Thyroid cancer_Homo sapiens_hsa052160.61771449
97Inositol phosphate metabolism_Homo sapiens_hsa005620.61204511
98Endocytosis_Homo sapiens_hsa041440.60748177
99Prion diseases_Homo sapiens_hsa050200.59716164
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59369309
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.58085534
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57814392
103Wnt signaling pathway_Homo sapiens_hsa043100.57039552
104Chemokine signaling pathway_Homo sapiens_hsa040620.56661902
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56518848
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56465204
107Collecting duct acid secretion_Homo sapiens_hsa049660.54353493
108Renal cell carcinoma_Homo sapiens_hsa052110.54261173
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53618083
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52749469
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51862009
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51835328
113Platelet activation_Homo sapiens_hsa046110.51391796
114Insulin signaling pathway_Homo sapiens_hsa049100.51147595
115Bile secretion_Homo sapiens_hsa049760.50936956
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48413480
117African trypanosomiasis_Homo sapiens_hsa051430.48219510
118Proteoglycans in cancer_Homo sapiens_hsa052050.46698468
119Colorectal cancer_Homo sapiens_hsa052100.46205444
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46163519
121Prolactin signaling pathway_Homo sapiens_hsa049170.45446051
122Type I diabetes mellitus_Homo sapiens_hsa049400.44469477
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.44441682
124Chronic myeloid leukemia_Homo sapiens_hsa052200.42797900
125Alcoholism_Homo sapiens_hsa050340.40994808
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40089896
127T cell receptor signaling pathway_Homo sapiens_hsa046600.39614947
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38979977
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38338542
130Circadian rhythm_Homo sapiens_hsa047100.37282074
131HIF-1 signaling pathway_Homo sapiens_hsa040660.37269569
132Focal adhesion_Homo sapiens_hsa045100.36777639

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