SIKE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.60690641
2regulation of centriole replication (GO:0046599)4.55995916
3DNA double-strand break processing (GO:0000729)4.51361279
4nuclear pore organization (GO:0006999)4.40346724
5chromatin remodeling at centromere (GO:0031055)4.16764414
6CENP-A containing nucleosome assembly (GO:0034080)4.11240360
7double-strand break repair via nonhomologous end joining (GO:0006303)3.79013381
8non-recombinational repair (GO:0000726)3.79013381
9mitotic sister chromatid cohesion (GO:0007064)3.72948770
10histone exchange (GO:0043486)3.68328524
11proteasome assembly (GO:0043248)3.61424715
12DNA replication checkpoint (GO:0000076)3.56660439
13protein localization to kinetochore (GO:0034501)3.52811543
14negative regulation of DNA-dependent DNA replication (GO:2000104)3.41678865
15regulation of DNA endoreduplication (GO:0032875)3.41433543
16DNA replication-independent nucleosome assembly (GO:0006336)3.36660664
17DNA replication-independent nucleosome organization (GO:0034724)3.36660664
18pore complex assembly (GO:0046931)3.34754713
19DNA replication-dependent nucleosome assembly (GO:0006335)3.31065722
20DNA replication-dependent nucleosome organization (GO:0034723)3.31065722
21establishment of integrated proviral latency (GO:0075713)3.30810528
22spindle checkpoint (GO:0031577)3.28367130
23peptidyl-histidine modification (GO:0018202)3.25502755
24establishment of nucleus localization (GO:0040023)3.24917638
25protein K6-linked ubiquitination (GO:0085020)3.21182898
26mitotic spindle checkpoint (GO:0071174)3.20912236
27negative regulation of mitotic sister chromatid separation (GO:2000816)3.19125398
28negative regulation of sister chromatid segregation (GO:0033046)3.19125398
29negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19125398
30negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.19125398
31negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19125398
32viral mRNA export from host cell nucleus (GO:0046784)3.18819384
33replication fork processing (GO:0031297)3.17922363
34regulation of mitotic spindle checkpoint (GO:1903504)3.17536800
35regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17536800
36DNA strand elongation involved in DNA replication (GO:0006271)3.17131256
37negative regulation of chromosome segregation (GO:0051985)3.16580966
38mitotic metaphase plate congression (GO:0007080)3.16263684
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14214683
40DNA ligation (GO:0006266)3.13444519
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.12741933
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12741933
43purine nucleobase biosynthetic process (GO:0009113)3.12166176
44ribosome assembly (GO:0042255)3.11365360
45DNA catabolic process, exonucleolytic (GO:0000738)3.11063899
46DNA strand elongation (GO:0022616)3.10579663
47kinetochore organization (GO:0051383)3.10028925
48cytoplasmic mRNA processing body assembly (GO:0033962)3.04667794
49protein localization to chromosome, centromeric region (GO:0071459)3.04173813
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.03950887
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03704005
52IMP biosynthetic process (GO:0006188)3.03187268
53regulation of centrosome cycle (GO:0046605)3.02994315
54mitotic spindle assembly checkpoint (GO:0007094)3.02436970
55maturation of 5.8S rRNA (GO:0000460)3.01671742
56regulation of somitogenesis (GO:0014807)3.01270717
57regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01158947
58regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01158947
59telomere maintenance via semi-conservative replication (GO:0032201)3.00584059
60spindle assembly checkpoint (GO:0071173)2.99761157
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99398915
62metaphase plate congression (GO:0051310)2.98582160
63regulation of sister chromatid segregation (GO:0033045)2.97008593
64regulation of mitotic sister chromatid separation (GO:0010965)2.97008593
65regulation of mitotic sister chromatid segregation (GO:0033047)2.97008593
66sister chromatid segregation (GO:0000819)2.95258073
67mitotic nuclear envelope disassembly (GO:0007077)2.94409412
68resolution of meiotic recombination intermediates (GO:0000712)2.93577561
69synapsis (GO:0007129)2.92973259
70regulation of chromosome segregation (GO:0051983)2.92259787
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92115663
72somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91683457
73somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91683457
74isotype switching (GO:0045190)2.91683457
75mitotic recombination (GO:0006312)2.90304674
76regulation of helicase activity (GO:0051095)2.88788369
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88247881
78negative regulation of DNA recombination (GO:0045910)2.87079356
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86389424
80response to X-ray (GO:0010165)2.85977506
81regulation of centrosome duplication (GO:0010824)2.85458691
82mitotic sister chromatid segregation (GO:0000070)2.85351323
83nucleobase biosynthetic process (GO:0046112)2.83479034
84cullin deneddylation (GO:0010388)2.83002178
85DNA damage response, detection of DNA damage (GO:0042769)2.82915517
86histone H2A acetylation (GO:0043968)2.81057730
87venous blood vessel morphogenesis (GO:0048845)2.80589060
88negative regulation of axon extension involved in axon guidance (GO:0048843)2.79826208
89nucleus localization (GO:0051647)2.77957278
90kinetochore assembly (GO:0051382)2.76907076
91negative regulation of axon guidance (GO:1902668)2.75250520
92regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.74771590
93maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74132332
94amino acid activation (GO:0043038)2.73957105
95tRNA aminoacylation (GO:0043039)2.73957105
96recombinational repair (GO:0000725)2.73090013
97regulation of coenzyme metabolic process (GO:0051196)2.72270222
98regulation of cofactor metabolic process (GO:0051193)2.72270222
99double-strand break repair via homologous recombination (GO:0000724)2.71875922
100attachment of spindle microtubules to kinetochore (GO:0008608)2.71848408
101somatic recombination of immunoglobulin gene segments (GO:0016447)2.71728214
102protein deneddylation (GO:0000338)2.71687940
103regulation of acyl-CoA biosynthetic process (GO:0050812)2.71262429
104negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71217457
105negative regulation of ligase activity (GO:0051352)2.71217457
106DNA topological change (GO:0006265)2.70873697
107synaptic vesicle docking involved in exocytosis (GO:0016081)2.70461939
108mitotic G2/M transition checkpoint (GO:0044818)2.70151376
109head development (GO:0060322)2.68133585
110response to pheromone (GO:0019236)2.64687409
111layer formation in cerebral cortex (GO:0021819)2.62704979
112central nervous system projection neuron axonogenesis (GO:0021952)2.60079057
113dendrite morphogenesis (GO:0048813)2.58614272
114histone H3-K4 trimethylation (GO:0080182)2.58198426
115cerebral cortex radially oriented cell migration (GO:0021799)2.57105147
116regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54440402
117negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.53593263
118neuron projection extension involved in neuron projection guidance (GO:1902284)2.53337529
119axon extension involved in axon guidance (GO:0048846)2.53337529
120synaptic vesicle maturation (GO:0016188)2.52663685
121axonal fasciculation (GO:0007413)2.51526792
122dendritic spine morphogenesis (GO:0060997)2.51182351
123neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.48735375
124regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47654453
125negative regulation of axon extension (GO:0030517)2.47217270
126regulation of axon guidance (GO:1902667)2.43924566
127locomotory exploration behavior (GO:0035641)2.43226937
128regulation of axon extension involved in axon guidance (GO:0048841)2.42493186
129cardiac myofibril assembly (GO:0055003)2.40714857
130postsynaptic membrane organization (GO:0001941)2.34878678
131cerebellar Purkinje cell differentiation (GO:0021702)2.30035072
132lateral sprouting from an epithelium (GO:0060601)2.29879330
133regulation of sarcomere organization (GO:0060297)2.29352872
134neuron recognition (GO:0008038)2.27984827
135regulation of cell communication by electrical coupling (GO:0010649)2.25042576
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.24427519
137positive regulation of potassium ion transmembrane transport (GO:1901381)2.19769715
138neuron cell-cell adhesion (GO:0007158)2.18509851
139interkinetic nuclear migration (GO:0022027)2.18143360
140cell communication by electrical coupling (GO:0010644)2.17675798
141planar cell polarity pathway involved in neural tube closure (GO:0090179)2.17330890
142atrial cardiac muscle cell action potential (GO:0086014)2.16298800
143vocalization behavior (GO:0071625)2.15838433
144atrial septum morphogenesis (GO:0060413)2.14683994
145regulation of guanylate cyclase activity (GO:0031282)2.14253894
146regulation of establishment of planar polarity (GO:0090175)2.13898442
147neuronal stem cell maintenance (GO:0097150)2.12760700
148negative regulation of catenin import into nucleus (GO:0035414)2.12439355
149axon extension (GO:0048675)2.12380271
150stress granule assembly (GO:0034063)2.11196037
151cardiac muscle hypertrophy (GO:0003300)2.09231569
152Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.09226385
153forebrain neuron differentiation (GO:0021879)2.07864697
154innervation (GO:0060384)2.07698959
155negative regulation of translation, ncRNA-mediated (GO:0040033)2.07138382
156regulation of translation, ncRNA-mediated (GO:0045974)2.07138382
157negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.07138382
158pyrimidine nucleobase catabolic process (GO:0006208)2.05621203
159presynaptic membrane assembly (GO:0097105)2.05591502
160regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.04936629
161regulation of glutamate receptor signaling pathway (GO:1900449)2.02405988
162regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.01962255
163regulation of synapse structural plasticity (GO:0051823)2.01274608
164negative regulation of potassium ion transmembrane transport (GO:1901380)2.00975604
165dendrite development (GO:0016358)2.00970440
166regulation of relaxation of muscle (GO:1901077)2.00475784
167central nervous system neuron axonogenesis (GO:0021955)2.00305235
168positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.00191204
169regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.99692854
170mRNA splice site selection (GO:0006376)1.99074758
171positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)1.99027055
172regulation of inhibitory postsynaptic membrane potential (GO:0060080)1.98537042
173negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.98477186
174negative regulation of cell killing (GO:0031342)1.98477186
175negative regulation of axonogenesis (GO:0050771)1.97612149
176ionotropic glutamate receptor signaling pathway (GO:0035235)1.97561773
177regulation of non-canonical Wnt signaling pathway (GO:2000050)1.97520185
178membrane repolarization (GO:0086009)1.97389137
179peptidyl-tyrosine autophosphorylation (GO:0038083)1.97282249
180regulation of cardiac muscle cell apoptotic process (GO:0010665)1.97112737
181cell proliferation involved in metanephros development (GO:0072203)1.96652582
182glomerular filtration (GO:0003094)1.95644333
183regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)1.94843821
184retinal ganglion cell axon guidance (GO:0031290)1.94463874
185regulation of T cell tolerance induction (GO:0002664)1.93618525
186apical protein localization (GO:0045176)1.93536415
187negative regulation of striated muscle cell apoptotic process (GO:0010664)1.93534380
188camera-type eye morphogenesis (GO:0048593)1.93091364
189regulation of axon extension (GO:0030516)1.92884275
190hippo signaling (GO:0035329)1.92862164
191positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.92328292
192striated muscle hypertrophy (GO:0014897)1.92151570
193positive T cell selection (GO:0043368)1.91889702
194anatomical structure arrangement (GO:0048532)1.91792741
195cardiac chamber formation (GO:0003207)1.91777191
196retina layer formation (GO:0010842)1.91407989
197membrane repolarization during cardiac muscle cell action potential (GO:0086013)1.90807568
198positive regulation of dendritic spine morphogenesis (GO:0061003)1.90806609
199peptidyl-lysine trimethylation (GO:0018023)1.90361491
200neuron projection extension (GO:1990138)1.89911078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.87508286
2E2F7_22180533_ChIP-Seq_HELA_Human5.61090625
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.90524550
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80629854
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.28385361
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.07965921
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04019411
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.00810146
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.98767570
10ELK1_19687146_ChIP-ChIP_HELA_Human2.83232242
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.69130907
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64407779
13GBX2_23144817_ChIP-Seq_PC3_Human2.61538646
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52709863
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51025875
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.50928296
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50067028
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31683679
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30227389
20PADI4_21655091_ChIP-ChIP_MCF-7_Human2.29013803
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28595573
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27876652
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.25148487
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18737163
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15398997
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12686586
27* EWS_26573619_Chip-Seq_HEK293_Human2.12637859
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11114055
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11114055
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.10543279
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09726828
32* VDR_23849224_ChIP-Seq_CD4+_Human2.09268415
33AR_21909140_ChIP-Seq_LNCAP_Human2.09182035
34EED_16625203_ChIP-ChIP_MESCs_Mouse2.03805657
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02609528
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01933473
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01851595
38DROSHA_22980978_ChIP-Seq_HELA_Human1.98984584
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96965667
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94942376
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94285155
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93094940
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92168374
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.91222940
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.87341143
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.87285152
47FOXP3_21729870_ChIP-Seq_TREG_Human1.86022680
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.83699239
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81357224
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80200609
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79093705
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77652140
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.77354533
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74753727
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73384307
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.72761359
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71778171
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70672875
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69494605
60DCP1A_22483619_ChIP-Seq_HELA_Human1.68171642
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66574455
62MYC_18940864_ChIP-ChIP_HL60_Human1.66356699
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66162397
64AHR_22903824_ChIP-Seq_MCF-7_Human1.64896503
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63258902
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63084272
67AR_21572438_ChIP-Seq_LNCaP_Human1.61034373
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.59583312
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58181652
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57708698
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.56914138
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54830323
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54388979
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49997948
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49785784
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48913558
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46307723
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44368179
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.43707938
80GABP_19822575_ChIP-Seq_HepG2_Human1.43703743
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40499169
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39498988
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.39320256
84ZNF274_21170338_ChIP-Seq_K562_Hela1.39105117
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38944985
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.38678349
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37868409
88TTF2_22483619_ChIP-Seq_HELA_Human1.37664791
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.36056752
90TAF15_26573619_Chip-Seq_HEK293_Human1.32250771
91VDR_22108803_ChIP-Seq_LS180_Human1.31547914
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30842977
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29060445
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28251688
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27621600
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26171392
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25853707
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25715080
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.25040310
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.24861038
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24066370
102ISL1_27105846_Chip-Seq_CPCs_Mouse1.22207939
103SMAD4_21799915_ChIP-Seq_A2780_Human1.22185562
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20711123
105TRIM28_21343339_ChIP-Seq_HEK293_Human1.20249947
106* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19581021
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19128350
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18947086
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.18017154
110* ER_23166858_ChIP-Seq_MCF-7_Human1.17256094
111NANOG_16153702_ChIP-ChIP_HESCs_Human1.17012909
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16998363
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16171788
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15593017
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15593017
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.14470184
117CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14440857
118ESR1_20079471_ChIP-ChIP_T-47D_Human1.14440335
119P300_19829295_ChIP-Seq_ESCs_Human1.13826460
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13440611
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13135174
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12796504
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11801524
124XRN2_22483619_ChIP-Seq_HELA_Human1.11666262
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11522454
126AR_19668381_ChIP-Seq_PC3_Human1.10680181
127RARB_27405468_Chip-Seq_BRAIN_Mouse1.10357284
128STAT3_23295773_ChIP-Seq_U87_Human1.10293795
129TP53_16413492_ChIP-PET_HCT116_Human1.09693037
130REST_21632747_ChIP-Seq_MESCs_Mouse1.09118515
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08969877
132RXR_22108803_ChIP-Seq_LS180_Human1.08673851
133FUS_26573619_Chip-Seq_HEK293_Human1.08162045
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07585253
135SMAD3_21741376_ChIP-Seq_EPCs_Human1.07084277
136CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05580493
137NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05438748
138ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05402281
139NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04614544
140SOX2_21211035_ChIP-Seq_LN229_Gbm1.04531535
141TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03864569
142ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02658859
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01646167
144SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01154908
145POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00964490
146TCF4_18268006_ChIP-ChIP_LS174T_Human1.00917107
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00041762
148KDM5A_27292631_Chip-Seq_BREAST_Human0.99636598
149CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99385659
150NOTCH1_21737748_ChIP-Seq_TLL_Human0.99181782
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98231016
152ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97665473
153SOX2_16153702_ChIP-ChIP_HESCs_Human0.97643375
154RUNX2_22187159_ChIP-Seq_PCA_Human0.97449776
155E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95923301
156IRF1_19129219_ChIP-ChIP_H3396_Human0.95619238
157HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95520052
158LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95491493
159IGF1R_20145208_ChIP-Seq_DFB_Human0.95460773
160BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95312402
161SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95065166
162FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94908959
163SOX17_20123909_ChIP-Seq_XEN_Mouse0.94698499
164PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93716660
165TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93479402
166RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93459075
167CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93300860
168AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93137291
169SALL1_21062744_ChIP-ChIP_HESCs_Human0.92905124
170EZH2_27294783_Chip-Seq_NPCs_Mouse0.92037005
171TP53_18474530_ChIP-ChIP_U2OS_Human0.91550600
172LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91319217
173RUNX_20019798_ChIP-Seq_JUKART_Human0.90583782
174SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88156969
175SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87744418
176MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86617049
177FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84418980
178SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84010953
179* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80582263
180NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80282771
181NANOG_18555785_ChIP-Seq_MESCs_Mouse0.79849497
182NFE2_27457419_Chip-Seq_LIVER_Mouse0.78444547
183DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77479592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.88154620
2MP0008057_abnormal_DNA_replication3.51732556
3MP0008058_abnormal_DNA_repair3.37861754
4MP0003693_abnormal_embryo_hatching3.30969067
5MP0004957_abnormal_blastocyst_morpholog2.98649301
6MP0003111_abnormal_nucleus_morphology2.94780119
7MP0003122_maternal_imprinting2.67753815
8MP0000569_abnormal_digit_pigmentation2.59357389
9MP0003077_abnormal_cell_cycle2.57701936
10MP0008877_abnormal_DNA_methylation2.43344397
11MP0008932_abnormal_embryonic_tissue2.35859046
12MP0008007_abnormal_cellular_replicative2.14639891
13MP0004859_abnormal_synaptic_plasticity2.11795508
14MP0009697_abnormal_copulation2.03795741
15MP0000778_abnormal_nervous_system1.95197979
16MP0009780_abnormal_chondrocyte_physiolo1.85342528
17MP0003786_premature_aging1.84758842
18MP0003718_maternal_effect1.81393557
19MP0000372_irregular_coat_pigmentation1.79950236
20MP0003937_abnormal_limbs/digits/tail_de1.77052119
21MP0002102_abnormal_ear_morphology1.75333793
22MP0001529_abnormal_vocalization1.68154002
23MP0004885_abnormal_endolymph1.67607401
24MP0005408_hypopigmentation1.62682475
25MP0003121_genomic_imprinting1.61378507
26MP0004084_abnormal_cardiac_muscle1.60206874
27MP0010307_abnormal_tumor_latency1.54150981
28MP0000733_abnormal_muscle_development1.52639099
29MP0001188_hyperpigmentation1.51617044
30MP0006035_abnormal_mitochondrial_morpho1.49655563
31MP0002234_abnormal_pharynx_morphology1.49501231
32MP0005187_abnormal_penis_morphology1.48304397
33MP0004272_abnormal_basement_membrane1.47947117
34MP0004484_altered_response_of1.47491283
35MP0000751_myopathy1.47220143
36MP0003635_abnormal_synaptic_transmissio1.44587657
37MP0010030_abnormal_orbit_morphology1.44564596
38MP0001299_abnormal_eye_distance/1.43387070
39MP0005380_embryogenesis_phenotype1.42595999
40MP0001672_abnormal_embryogenesis/_devel1.42595999
41MP0002653_abnormal_ependyma_morphology1.41886973
42MP0000427_abnormal_hair_cycle1.41166981
43MP0001697_abnormal_embryo_size1.40628798
44MP0002938_white_spotting1.40245919
45MP0000647_abnormal_sebaceous_gland1.39645389
46MP0005075_abnormal_melanosome_morpholog1.39250333
47MP0001293_anophthalmia1.38660865
48MP0003880_abnormal_central_pattern1.38321737
49MP0006054_spinal_hemorrhage1.36491494
50MP0002084_abnormal_developmental_patter1.36178169
51MP0001730_embryonic_growth_arrest1.33721736
52MP0003385_abnormal_body_wall1.31948397
53MP0001486_abnormal_startle_reflex1.31403902
54MP0009672_abnormal_birth_weight1.31177446
55MP0003137_abnormal_impulse_conducting1.30324137
56MP0008995_early_reproductive_senescence1.28325829
57MP0002127_abnormal_cardiovascular_syste1.27794715
58MP0000350_abnormal_cell_proliferation1.27415561
59MP0003183_abnormal_peptide_metabolism1.26677088
60MP0003984_embryonic_growth_retardation1.26579935
61MP0005377_hearing/vestibular/ear_phenot1.26446022
62MP0003878_abnormal_ear_physiology1.26446022
63MP0002088_abnormal_embryonic_growth/wei1.26088950
64MP0003935_abnormal_craniofacial_develop1.26088707
65MP0006292_abnormal_olfactory_placode1.26017847
66MP0002160_abnormal_reproductive_system1.25486413
67MP0005409_darkened_coat_color1.24950463
68MP0006072_abnormal_retinal_apoptosis1.23276980
69MP0004270_analgesia1.20797085
70MP0004215_abnormal_myocardial_fiber1.20583351
71MP0005367_renal/urinary_system_phenotyp1.20430824
72MP0000516_abnormal_urinary_system1.20430824
73MP0002184_abnormal_innervation1.20152374
74MP0003123_paternal_imprinting1.20140532
75MP0005248_abnormal_Harderian_gland1.19083247
76MP0003941_abnormal_skin_development1.18624892
77MP0002085_abnormal_embryonic_tissue1.18417562
78MP0000428_abnormal_craniofacial_morphol1.18352497
79MP0003136_yellow_coat_color1.17101200
80MP0003315_abnormal_perineum_morphology1.16434472
81MP0004133_heterotaxia1.16257126
82MP0002972_abnormal_cardiac_muscle1.15877472
83MP0003567_abnormal_fetal_cardiomyocyte1.14825334
84MP0002557_abnormal_social/conspecific_i1.14084769
85MP0001286_abnormal_eye_development1.14075262
86MP0009703_decreased_birth_body1.12070026
87MP0005551_abnormal_eye_electrophysiolog1.11135314
88MP0005503_abnormal_tendon_morphology1.10868762
89MP0003861_abnormal_nervous_system1.10785818
90MP0003938_abnormal_ear_development1.10484869
91MP0002063_abnormal_learning/memory/cond1.10226280
92MP0005253_abnormal_eye_physiology1.10026556
93MP0003119_abnormal_digestive_system1.09762229
94MP0004085_abnormal_heartbeat1.08136749
95MP0010352_gastrointestinal_tract_polyps1.07532767
96MP0001661_extended_life_span1.06796649
97MP0003942_abnormal_urinary_system1.06476131
98MP0002697_abnormal_eye_size1.04883418
99MP0000049_abnormal_middle_ear1.04045786
100MP0002009_preneoplasia1.03629118
101MP0002882_abnormal_neuron_morphology1.03261915
102MP0010234_abnormal_vibrissa_follicle1.01894016
103MP0002932_abnormal_joint_morphology1.01637834
104MP0004197_abnormal_fetal_growth/weight/1.00550951
105MP0003890_abnormal_embryonic-extraembry1.00468403
106MP0008569_lethality_at_weaning1.00425886
107MP0000358_abnormal_cell_content/1.00090294
108MP0006036_abnormal_mitochondrial_physio0.99921982
109MP0009250_abnormal_appendicular_skeleto0.99767763
110MP0002210_abnormal_sex_determination0.99645494
111MP0008789_abnormal_olfactory_epithelium0.99518890
112MP0000631_abnormal_neuroendocrine_gland0.99186634
113MP0001879_abnormal_lymphatic_vessel0.97609531
114MP0002067_abnormal_sensory_capabilities0.97430944
115MP0005499_abnormal_olfactory_system0.97331103
116MP0005394_taste/olfaction_phenotype0.97331103
117MP0004087_abnormal_muscle_fiber0.96931981
118MP0003787_abnormal_imprinting0.96784102
119MP0002116_abnormal_craniofacial_bone0.96731292
120MP0001929_abnormal_gametogenesis0.96563020
121MP0002080_prenatal_lethality0.96474785
122MP0002572_abnormal_emotion/affect_behav0.95591866
123MP0000534_abnormal_ureter_morphology0.95115783
124MP0000955_abnormal_spinal_cord0.94574310
125MP0005423_abnormal_somatic_nervous0.94254609
126MP0010630_abnormal_cardiac_muscle0.94094378
127MP0006276_abnormal_autonomic_nervous0.93193205
128MP0010678_abnormal_skin_adnexa0.93157542
129MP0002152_abnormal_brain_morphology0.93015057
130MP0004145_abnormal_muscle_electrophysio0.91684394
131MP0005623_abnormal_meninges_morphology0.90903345
132MP0002909_abnormal_adrenal_gland0.90347257
133MP0003828_pulmonary_edema0.90179679
134MP0005620_abnormal_muscle_contractility0.89569103
135MP0000653_abnormal_sex_gland0.88660922
136MP0002233_abnormal_nose_morphology0.88022094
137MP0003221_abnormal_cardiomyocyte_apopto0.87603045
138MP0001145_abnormal_male_reproductive0.87387142
139MP0002638_abnormal_pupillary_reflex0.87068948
140MP0005391_vision/eye_phenotype0.86908382
141MP0002089_abnormal_postnatal_growth/wei0.86684554
142MP0003186_abnormal_redox_activity0.86605756
143MP0002177_abnormal_outer_ear0.85550640
144MP0000383_abnormal_hair_follicle0.84905538
145MP0001177_atelectasis0.84489428
146MP0000537_abnormal_urethra_morphology0.84345278
147MP0004924_abnormal_behavior0.84246465
148MP0005386_behavior/neurological_phenoty0.84246465
149MP0002925_abnormal_cardiovascular_devel0.84129418
150MP0002090_abnormal_vision0.83529299
151MP0004036_abnormal_muscle_relaxation0.83236156
152MP0001119_abnormal_female_reproductive0.83230092
153MP0002751_abnormal_autonomic_nervous0.83069638
154MP0002111_abnormal_tail_morphology0.83021853
155MP0003091_abnormal_cell_migration0.82919685
156MP0002752_abnormal_somatic_nervous0.82865898
157MP0005389_reproductive_system_phenotype0.82076885
158MP0005084_abnormal_gallbladder_morpholo0.81647015
159MP0004811_abnormal_neuron_physiology0.81188833
160MP0004233_abnormal_muscle_weight0.79948855
161MP0005330_cardiomyopathy0.79643021
162MP0002086_abnormal_extraembryonic_tissu0.79451429
163MP0001968_abnormal_touch/_nociception0.79024022
164MP0005645_abnormal_hypothalamus_physiol0.78739329
165MP0002064_seizures0.78575686
166MP0003755_abnormal_palate_morphology0.78431483
167MP0003806_abnormal_nucleotide_metabolis0.78324044
168MP0005195_abnormal_posterior_eye0.78117693
169MP0005171_absent_coat_pigmentation0.77561030
170MP0002735_abnormal_chemical_nociception0.77296177
171MP0003943_abnormal_hepatobiliary_system0.76732927
172MP0000313_abnormal_cell_death0.74816781
173MP0001986_abnormal_taste_sensitivity0.73908731
174MP0001727_abnormal_embryo_implantation0.73722827
175MP0005220_abnormal_exocrine_pancreas0.72823368
176MP0002095_abnormal_skin_pigmentation0.72558729
177MP0002396_abnormal_hematopoietic_system0.71497483

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.69556936
2Chromsome breakage (HP:0040012)4.53004414
3Abnormality of chromosome stability (HP:0003220)3.93294374
4Meckel diverticulum (HP:0002245)3.73790656
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.66731903
6Abnormality of the ileum (HP:0001549)3.61719198
7Abnormality of the preputium (HP:0100587)3.40084759
8Volvulus (HP:0002580)3.30886925
9Nephroblastoma (Wilms tumor) (HP:0002667)3.18714508
10Broad metatarsal (HP:0001783)3.10563328
11Embryonal renal neoplasm (HP:0011794)3.04465844
12Short 4th metacarpal (HP:0010044)2.91864162
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.91864162
14Duodenal stenosis (HP:0100867)2.91317380
15Small intestinal stenosis (HP:0012848)2.91317380
16Colon cancer (HP:0003003)2.79316656
17Abnormal lung lobation (HP:0002101)2.71010973
18Abnormality of the duodenum (HP:0002246)2.70098782
19Intestinal atresia (HP:0011100)2.66500020
20Genetic anticipation (HP:0003743)2.65071929
21Neoplasm of the adrenal gland (HP:0100631)2.59977492
22Prolonged QT interval (HP:0001657)2.58143611
23Abnormality of glycolysis (HP:0004366)2.57335472
24Midline defect of the nose (HP:0004122)2.55742468
25Increased hepatocellular lipid droplets (HP:0006565)2.51094303
26Renal duplication (HP:0000075)2.48098509
27Increased serum pyruvate (HP:0003542)2.44932159
28Thyroid carcinoma (HP:0002890)2.43603118
29Papillary thyroid carcinoma (HP:0002895)2.41786390
30Narrow palate (HP:0000189)2.39969927
31Abnormality of the carotid arteries (HP:0005344)2.36013457
32Neoplasm of the heart (HP:0100544)2.34353599
33Sloping forehead (HP:0000340)2.33955901
34Abnormality of methionine metabolism (HP:0010901)2.32555010
35Breast carcinoma (HP:0003002)2.30627105
36Clubbing of toes (HP:0100760)2.29239205
37Rhabdomyosarcoma (HP:0002859)2.27715022
38Neoplasm of the adrenal cortex (HP:0100641)2.25168174
39Aqueductal stenosis (HP:0002410)2.24599991
40Abnormality of the labia minora (HP:0012880)2.22049810
41Triphalangeal thumb (HP:0001199)2.21404022
42Medulloblastoma (HP:0002885)2.17803374
43Abnormality of the right ventricle (HP:0001707)2.17674151
44Drooling (HP:0002307)2.17198236
45Excessive salivation (HP:0003781)2.17198236
46Acute encephalopathy (HP:0006846)2.15705119
47Acute necrotizing encephalopathy (HP:0006965)2.12742414
48Methylmalonic acidemia (HP:0002912)2.12007268
49Myelodysplasia (HP:0002863)2.10527779
50Sudden death (HP:0001699)2.10487979
51Cutaneous melanoma (HP:0012056)2.07169872
52Broad-based gait (HP:0002136)2.06810445
53Centrally nucleated skeletal muscle fibers (HP:0003687)2.06590274
54Lipid accumulation in hepatocytes (HP:0006561)2.04952647
55Atrial fibrillation (HP:0005110)2.04300718
56Increased CSF lactate (HP:0002490)2.04240420
57Aortic aneurysm (HP:0004942)2.03267757
58Primary atrial arrhythmia (HP:0001692)2.02031049
59Pheochromocytoma (HP:0002666)2.00211487
60Pancreatic islet-cell hyperplasia (HP:0004510)1.99645394
61Abnormality of the phalanges of the hallux (HP:0010057)1.97631830
62Progressive macrocephaly (HP:0004481)1.96643949
63Abnormal EKG (HP:0003115)1.96449963
64Ependymoma (HP:0002888)1.96283808
65Anteriorly placed anus (HP:0001545)1.95989796
66Cortical dysplasia (HP:0002539)1.95320376
67Ectopic kidney (HP:0000086)1.94257518
68Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94216911
69Microglossia (HP:0000171)1.93910381
70Calf muscle hypertrophy (HP:0008981)1.93850663
71Abnormality of the 4th metacarpal (HP:0010012)1.93730236
72Increased nuchal translucency (HP:0010880)1.93082155
73Hepatoblastoma (HP:0002884)1.92600409
74Abnormality of the left ventricular outflow tract (HP:0011103)1.92577668
75Subaortic stenosis (HP:0001682)1.92577668
76Embryonal neoplasm (HP:0002898)1.92525937
77Birth length less than 3rd percentile (HP:0003561)1.92112285
78Overriding aorta (HP:0002623)1.91816023
79Abnormality of serum amino acid levels (HP:0003112)1.91737675
80Abnormality of the distal phalanx of the thumb (HP:0009617)1.91385128
81Hyperacusis (HP:0010780)1.89959337
82Trigonocephaly (HP:0000243)1.89585125
83Macroorchidism (HP:0000053)1.88368352
84Gonadotropin excess (HP:0000837)1.87944724
85Long nose (HP:0003189)1.87659244
86Pancreatic cysts (HP:0001737)1.87392217
87Central scotoma (HP:0000603)1.85658583
88Cutaneous finger syndactyly (HP:0010554)1.85466010
89Flat cornea (HP:0007720)1.85249317
90Shallow orbits (HP:0000586)1.84908305
91Arteriovenous malformation (HP:0100026)1.84427860
92Astigmatism (HP:0000483)1.84345873
93Ovarian neoplasm (HP:0100615)1.84266893
94Neuroendocrine neoplasm (HP:0100634)1.83926728
95Progressive inability to walk (HP:0002505)1.83438545
96Supernumerary ribs (HP:0005815)1.83412740
97Supraventricular tachycardia (HP:0004755)1.83153928
98Elfin facies (HP:0004428)1.82836801
99Syncope (HP:0001279)1.81031431
100Abnormality of alanine metabolism (HP:0010916)1.80123492
101Hyperalaninemia (HP:0003348)1.80123492
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80123492
103Abnormality of the astrocytes (HP:0100707)1.79360881
104Astrocytoma (HP:0009592)1.79360881
105Supraventricular arrhythmia (HP:0005115)1.79288693
106Renal cortical cysts (HP:0000803)1.79238540
107Cerebral edema (HP:0002181)1.78617860
108Hyperglycinemia (HP:0002154)1.77942212
109Wrist flexion contracture (HP:0001239)1.77795207
110Aplasia/Hypoplasia of the tongue (HP:0010295)1.76785554
111Progressive cerebellar ataxia (HP:0002073)1.76325554
112Abnormal mitochondria in muscle tissue (HP:0008316)1.76255085
113Mitochondrial inheritance (HP:0001427)1.76127396
114Absent eyebrow (HP:0002223)1.75442637
115Pustule (HP:0200039)1.75313195
116Muscle hypertrophy of the lower extremities (HP:0008968)1.75306757
117Exotropia (HP:0000577)1.74313510
118Bifid tongue (HP:0010297)1.74115832
119Adrenal hypoplasia (HP:0000835)1.73210266
120Ankyloglossia (HP:0010296)1.72325878
121Neoplasm of the colon (HP:0100273)1.72321137
122Abnormality of oral frenula (HP:0000190)1.71234501
123Meningioma (HP:0002858)1.71090733
124Absent radius (HP:0003974)1.70485570
125Cafe-au-lait spot (HP:0000957)1.69867234
126Cutaneous syndactyly (HP:0012725)1.68629177
127Pancreatic fibrosis (HP:0100732)1.68511640
128Dandy-Walker malformation (HP:0001305)1.66920455
129Epileptic encephalopathy (HP:0200134)1.66374999
130Renal Fanconi syndrome (HP:0001994)1.65954189
131Supernumerary spleens (HP:0009799)1.65778728
132Increased serum lactate (HP:0002151)1.64995446
133Ankle clonus (HP:0011448)1.63244739
134Degeneration of anterior horn cells (HP:0002398)1.63125835
135Abnormality of the anterior horn cell (HP:0006802)1.63125835
136Gastrointestinal atresia (HP:0002589)1.63088418
137Asymmetry of the thorax (HP:0001555)1.62668244
138Hypoglycemic coma (HP:0001325)1.62266599
139Choanal atresia (HP:0000453)1.61181299
140Abnormality of the calf musculature (HP:0001430)1.60749624
141Ectopic anus (HP:0004397)1.60300971
142Type I transferrin isoform profile (HP:0003642)1.58967596
143Congenital stationary night blindness (HP:0007642)1.57967425
144True hermaphroditism (HP:0010459)1.57774217
145Absent forearm bone (HP:0003953)1.57682364
146Aplasia involving forearm bones (HP:0009822)1.57682364
147Tented upper lip vermilion (HP:0010804)1.57590393
148Myelomeningocele (HP:0002475)1.57413844
149Deep philtrum (HP:0002002)1.56626664
150Degeneration of the lateral corticospinal tracts (HP:0002314)1.56596788
151Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.56596788
152Microvesicular hepatic steatosis (HP:0001414)1.56381616
153Abnormal umbilical cord blood vessels (HP:0011403)1.56302919
154Single umbilical artery (HP:0001195)1.56302919
155Abnormality of the fetal cardiovascular system (HP:0010948)1.56302919
156Abnormality of salivation (HP:0100755)1.56130452
157Increased number of teeth (HP:0011069)1.55772711
158Neoplasm of the thyroid gland (HP:0100031)1.55463899
159Hepatic necrosis (HP:0002605)1.55317603
160Obsessive-compulsive behavior (HP:0000722)1.54807647
161Short philtrum (HP:0000322)1.54507610
162Sacral dimple (HP:0000960)1.53693598
163Agitation (HP:0000713)1.53187358
164Hypoplasia of the maxilla (HP:0000327)1.52360213
165Dyschromatopsia (HP:0007641)1.52323656
166Abnormality of the tricuspid valve (HP:0001702)1.50696767
167Omphalocele (HP:0001539)1.50241677
168Supernumerary bones of the axial skeleton (HP:0009144)1.48126392
169Truncal ataxia (HP:0002078)1.47971463
170Aplasia/Hypoplasia of the brainstem (HP:0007362)1.47932575
171Hypoplasia of the brainstem (HP:0002365)1.47932575
172Dental malocclusion (HP:0000689)1.47541518
173Morphological abnormality of the middle ear (HP:0008609)1.46897089
174Abnormality of the intervertebral disk (HP:0005108)1.43941147
175Bundle branch block (HP:0011710)1.43918828
176Protruding tongue (HP:0010808)1.43803235
177Decreased lacrimation (HP:0000633)1.43616094
178Lymphangioma (HP:0100764)1.42873315
179Meningocele (HP:0002435)1.42865343
180Anal stenosis (HP:0002025)1.42594378
181Open mouth (HP:0000194)1.42290897
182Pointed chin (HP:0000307)1.41367884
183Glioma (HP:0009733)1.41262680
184Aplasia/Hypoplasia of the clavicles (HP:0006710)1.41148950
185Short clavicles (HP:0000894)1.40397911
186Megalencephaly (HP:0001355)1.40352183
187Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.40006061
188Febrile seizures (HP:0002373)1.39972365
189Long eyelashes (HP:0000527)1.39472515
190Pulmonic stenosis (HP:0001642)1.39079884
191Decreased circulating renin level (HP:0003351)1.38876435
192Patellar dislocation (HP:0002999)1.38810698
193Exostoses (HP:0100777)1.36904801
194Macrotia (HP:0000400)1.36581193
195Mitral regurgitation (HP:0001653)1.36524855
196Scotoma (HP:0000575)1.36327942
197Congenital sensorineural hearing impairment (HP:0008527)1.36029653
198Supranuclear gaze palsy (HP:0000605)1.35625329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.91336452
2SIK33.66923051
3TRIM283.46093106
4BUB13.30273745
5EIF2AK33.09982026
6TNIK2.98338955
7PBK2.93435904
8SIK22.81351130
9EIF2AK12.77148581
10PIK3CA2.64947579
11TTK2.64702183
12WEE12.57190466
13TSSK62.54781921
14MKNK12.33603264
15CDC72.24322383
16PLK42.21238785
17PLK32.19011954
18FRK2.18348620
19DMPK2.10206886
20ERBB32.03360897
21NTRK21.99434872
22MARK21.96282940
23BRSK21.93183183
24CDK121.90757265
25NEK11.87917135
26CAMK1G1.85653627
27MAPK131.83875664
28BMPR1B1.81249964
29ACVR1B1.79482374
30MST41.79090975
31TAF11.77859083
32NUAK11.76263591
33MAP4K21.73773879
34CAMK1D1.64051010
35PLK21.61731465
36LMTK21.55992543
37WNK11.48614987
38CSNK1A1L1.44313705
39PLK11.43810613
40PRPF4B1.43602117
41KSR11.42158641
42CDC42BPA1.40398054
43MARK31.37860119
44EPHB21.35030673
45EIF2AK21.34577155
46UHMK11.32799521
47PHKG11.30628830
48PHKG21.30628830
49VRK21.30568333
50BCR1.30370830
51PAK31.27812583
52FGFR21.26933535
53CDK31.26533243
54INSRR1.25793827
55NTRK31.14168422
56VRK11.12703893
57LATS11.12101226
58ATR1.11291245
59SRPK11.10777143
60AKT31.10239286
61CASK1.09757736
62CSNK1G21.08983961
63CHEK21.07501546
64DYRK21.04980142
65OBSCN1.03671670
66GRK71.03651423
67WNK31.01637063
68SCYL21.00481521
69FGFR11.00453106
70LIMK10.98961156
71BRD40.97814212
72SIK10.97370384
73PDGFRA0.97146822
74CSNK1G30.95649473
75PRKCH0.94921706
76STK30.93785467
77ATM0.93171810
78MAP3K70.91878382
79KDR0.87109618
80TYRO30.85740361
81CSNK1G10.85699436
82TGFBR20.85173326
83PRKD10.83720180
84CAMK40.83006773
85AURKB0.82748483
86STK38L0.81252839
87CDK70.81031070
88FGFR30.80864513
89CAMK10.80765317
90FYN0.78772731
91TGFBR10.78393942
92BRSK10.78028496
93MINK10.77254352
94MAP3K120.76556869
95SGK20.74744373
96DYRK1A0.73669798
97SGK30.73468153
98PDGFRB0.72516759
99STK390.72509589
100ERBB40.72348002
101PDK20.70480835
102RPS6KB20.69152658
103STK380.68141949
104ROCK10.65378432
105YES10.65112387
106CHEK10.64513433
107ITK0.64430739
108MAP3K40.64278561
109MYLK0.64186705
110CDK50.63937252
111TTN0.63672983
112NEK20.61816449
113STK40.61208346
114ERBB20.58017691
115PASK0.57651275
116ZAK0.57579397
117SGK4940.56845742
118SGK2230.56845742
119IRAK20.56489082
120ROCK20.56072501
121DYRK30.55107207
122CCNB10.54933964
123GRK10.54507639
124CDK180.53306490
125PKN20.53067819
126MKNK20.52888002
127DYRK1B0.51835025
128CAMK2D0.51202943
129CAMK2B0.50336328
130PRKCQ0.50314397
131MAPK90.49935998
132STK240.48165719
133RPS6KA40.48103167
134PRKD30.48100432
135JAK10.47647039
136DDR20.47560064
137STK160.47519614
138AKT20.47344069
139PRKG10.46610964
140CSNK2A10.46302263
141OXSR10.46274880
142NLK0.44645826
143PRKCE0.44512968
144CSNK1E0.44231393
145CDK140.43704014
146NEK60.43646868
147CDK150.42766655
148ALK0.42316061
149CDK10.41489092
150FLT30.41127654
151CLK10.41085051
152TAOK10.40902976
153PNCK0.40571529
154CSNK2A20.40322396
155PRKD20.40249260
156CDK60.37395253
157MELK0.36752311
158MUSK0.36108077
159CSNK1D0.34660224
160MAP2K70.34389203
161CDK20.33922596
162NME10.32399065
163RPS6KB10.31904000
164PRKDC0.31208225
165TIE10.30027640
166BCKDK0.30011075

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.56436472
2Proteasome_Homo sapiens_hsa030503.33889841
3Mismatch repair_Homo sapiens_hsa034303.02826006
4Homologous recombination_Homo sapiens_hsa034402.82012758
5Protein export_Homo sapiens_hsa030602.80847671
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79422217
7DNA replication_Homo sapiens_hsa030302.76683837
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.72442594
9Fanconi anemia pathway_Homo sapiens_hsa034602.58656662
10RNA transport_Homo sapiens_hsa030132.34529509
11Basal transcription factors_Homo sapiens_hsa030222.28517588
12RNA polymerase_Homo sapiens_hsa030202.28039376
13Spliceosome_Homo sapiens_hsa030402.09496235
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09040719
15Cell cycle_Homo sapiens_hsa041102.07458252
16Propanoate metabolism_Homo sapiens_hsa006402.06908096
17Nucleotide excision repair_Homo sapiens_hsa034202.06525989
18RNA degradation_Homo sapiens_hsa030182.06022109
19One carbon pool by folate_Homo sapiens_hsa006702.01171693
20Steroid biosynthesis_Homo sapiens_hsa001001.87595204
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79430330
22Axon guidance_Homo sapiens_hsa043601.76155776
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68753164
24Dilated cardiomyopathy_Homo sapiens_hsa054141.67393403
25Base excision repair_Homo sapiens_hsa034101.64849512
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60204409
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57549878
28Circadian entrainment_Homo sapiens_hsa047131.53779803
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53253445
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53251155
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51787591
32Phototransduction_Homo sapiens_hsa047441.49812016
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.48000607
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46992171
35Oxidative phosphorylation_Homo sapiens_hsa001901.46659413
36Parkinsons disease_Homo sapiens_hsa050121.45655754
37Viral myocarditis_Homo sapiens_hsa054161.41838011
38Fatty acid elongation_Homo sapiens_hsa000621.41100307
39Long-term potentiation_Homo sapiens_hsa047201.38350376
40Vitamin B6 metabolism_Homo sapiens_hsa007501.35805660
41mRNA surveillance pathway_Homo sapiens_hsa030151.34982804
42Nicotine addiction_Homo sapiens_hsa050331.32959594
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32072370
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30510048
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29199993
46Colorectal cancer_Homo sapiens_hsa052101.28540723
47Glutamatergic synapse_Homo sapiens_hsa047241.26414595
48Pyrimidine metabolism_Homo sapiens_hsa002401.24254237
49Olfactory transduction_Homo sapiens_hsa047401.23409546
50Cholinergic synapse_Homo sapiens_hsa047251.22050343
51Dopaminergic synapse_Homo sapiens_hsa047281.22036152
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19912660
53Adherens junction_Homo sapiens_hsa045201.19603759
54Morphine addiction_Homo sapiens_hsa050321.19122563
55Wnt signaling pathway_Homo sapiens_hsa043101.18890303
56Basal cell carcinoma_Homo sapiens_hsa052171.18386013
57Selenocompound metabolism_Homo sapiens_hsa004501.18086352
58Pyruvate metabolism_Homo sapiens_hsa006201.17729715
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16533775
60Huntingtons disease_Homo sapiens_hsa050161.13462132
61ErbB signaling pathway_Homo sapiens_hsa040121.13170263
62Renal cell carcinoma_Homo sapiens_hsa052111.12960135
63Endometrial cancer_Homo sapiens_hsa052131.12947716
64Purine metabolism_Homo sapiens_hsa002301.11061774
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10979602
66Primary immunodeficiency_Homo sapiens_hsa053401.10962549
67T cell receptor signaling pathway_Homo sapiens_hsa046601.09222431
68Oxytocin signaling pathway_Homo sapiens_hsa049211.09118949
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08753718
70Notch signaling pathway_Homo sapiens_hsa043301.08595325
71p53 signaling pathway_Homo sapiens_hsa041151.07371389
72Hedgehog signaling pathway_Homo sapiens_hsa043401.07362591
73Insulin secretion_Homo sapiens_hsa049111.05978530
74GABAergic synapse_Homo sapiens_hsa047271.05967542
75Leukocyte transendothelial migration_Homo sapiens_hsa046701.05948293
76Circadian rhythm_Homo sapiens_hsa047101.05509259
77Gastric acid secretion_Homo sapiens_hsa049711.04555115
78Ribosome_Homo sapiens_hsa030101.04217940
79Cardiac muscle contraction_Homo sapiens_hsa042601.03661079
80Folate biosynthesis_Homo sapiens_hsa007901.03419889
81Cocaine addiction_Homo sapiens_hsa050301.03250455
82Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02742240
83Oocyte meiosis_Homo sapiens_hsa041141.02704235
84Butanoate metabolism_Homo sapiens_hsa006501.02241540
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02213998
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00698471
87Carbon metabolism_Homo sapiens_hsa012001.00589669
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00367194
89Proteoglycans in cancer_Homo sapiens_hsa052050.99517403
90Serotonergic synapse_Homo sapiens_hsa047260.99474166
91Focal adhesion_Homo sapiens_hsa045100.99436856
92Hippo signaling pathway_Homo sapiens_hsa043900.98979095
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.97888525
94Amphetamine addiction_Homo sapiens_hsa050310.97481674
95cAMP signaling pathway_Homo sapiens_hsa040240.96757006
96Melanogenesis_Homo sapiens_hsa049160.96124998
97Long-term depression_Homo sapiens_hsa047300.95712324
98Biosynthesis of amino acids_Homo sapiens_hsa012300.95437665
99Salivary secretion_Homo sapiens_hsa049700.92997691
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92982492
101Rap1 signaling pathway_Homo sapiens_hsa040150.92931148
102Renin secretion_Homo sapiens_hsa049240.92336337
103Calcium signaling pathway_Homo sapiens_hsa040200.91839314
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90752419
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90750309
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90679199
107Glioma_Homo sapiens_hsa052140.90336817
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89871999
109Pancreatic cancer_Homo sapiens_hsa052120.85868575
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85472782
111Chronic myeloid leukemia_Homo sapiens_hsa052200.85123899
112Type II diabetes mellitus_Homo sapiens_hsa049300.84958988
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84753837
114Ras signaling pathway_Homo sapiens_hsa040140.84739098
115B cell receptor signaling pathway_Homo sapiens_hsa046620.83549039
116mTOR signaling pathway_Homo sapiens_hsa041500.82469675
117GnRH signaling pathway_Homo sapiens_hsa049120.79842616
118Gap junction_Homo sapiens_hsa045400.79820398
119Pathways in cancer_Homo sapiens_hsa052000.79360149
120Endocytosis_Homo sapiens_hsa041440.78801877
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.78279289
122Tight junction_Homo sapiens_hsa045300.78263543
123MicroRNAs in cancer_Homo sapiens_hsa052060.78110823
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77395420
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76512108
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76020628
127MAPK signaling pathway_Homo sapiens_hsa040100.75802865
128Alzheimers disease_Homo sapiens_hsa050100.75651278
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75630880
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75233235
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75075431
132TGF-beta signaling pathway_Homo sapiens_hsa043500.74980478
133FoxO signaling pathway_Homo sapiens_hsa040680.74975873
134Estrogen signaling pathway_Homo sapiens_hsa049150.74261655
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74226525
136Glutathione metabolism_Homo sapiens_hsa004800.73684569
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73403382
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.72435500
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.71867328
140Choline metabolism in cancer_Homo sapiens_hsa052310.71829215
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71500859
142Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71153783
143Fatty acid metabolism_Homo sapiens_hsa012120.71072666
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70638594
145Prostate cancer_Homo sapiens_hsa052150.70144870
146VEGF signaling pathway_Homo sapiens_hsa043700.69914626
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68829721
148N-Glycan biosynthesis_Homo sapiens_hsa005100.68807093
149Platelet activation_Homo sapiens_hsa046110.68676785
150Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68638858
151Non-small cell lung cancer_Homo sapiens_hsa052230.68580097
152Peroxisome_Homo sapiens_hsa041460.68572760
153Thyroid cancer_Homo sapiens_hsa052160.67679953
154ECM-receptor interaction_Homo sapiens_hsa045120.66702501
155Shigellosis_Homo sapiens_hsa051310.66083354
156Metabolic pathways_Homo sapiens_hsa011000.64223415
157Nitrogen metabolism_Homo sapiens_hsa009100.63493337
158Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62669476
159Small cell lung cancer_Homo sapiens_hsa052220.62368087
160Chemokine signaling pathway_Homo sapiens_hsa040620.62337401
161Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60210027
162Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58964268
163Sulfur metabolism_Homo sapiens_hsa009200.52756556
164Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48646818
165Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42847282
166Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41466620
167Pentose phosphate pathway_Homo sapiens_hsa000300.40280886
168Vitamin digestion and absorption_Homo sapiens_hsa049770.39859046
169Lysine degradation_Homo sapiens_hsa003100.38631575
170Alcoholism_Homo sapiens_hsa050340.35688130
171Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29240078
172Arginine and proline metabolism_Homo sapiens_hsa003300.28758646
173Fatty acid degradation_Homo sapiens_hsa000710.27532082
174Maturity onset diabetes of the young_Homo sapiens_hsa049500.27304460
175beta-Alanine metabolism_Homo sapiens_hsa004100.25886458
176Primary bile acid biosynthesis_Homo sapiens_hsa001200.24615888
177Sulfur relay system_Homo sapiens_hsa041220.22269561
178Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20990936
179SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20951614
180Tryptophan metabolism_Homo sapiens_hsa003800.20811636
181Drug metabolism - other enzymes_Homo sapiens_hsa009830.20364482
182Retinol metabolism_Homo sapiens_hsa008300.20338468
183Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20289866
184Fat digestion and absorption_Homo sapiens_hsa049750.18580120
185Fatty acid biosynthesis_Homo sapiens_hsa000610.17221760
186Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16836144
187Ether lipid metabolism_Homo sapiens_hsa005650.16644132

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »