SIGLEC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.71516640
2positive regulation by symbiont of host defense response (GO:0052509)5.65879306
3modulation by symbiont of host defense response (GO:0052031)5.65879306
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.65879306
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.65879306
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.65879306
7modulation by symbiont of host immune response (GO:0052553)5.65879306
8response to peptidoglycan (GO:0032494)5.55096651
9positive regulation of gamma-delta T cell activation (GO:0046645)5.44245720
10negative regulation of cell killing (GO:0031342)5.37210479
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.37210479
12negative regulation of interleukin-12 production (GO:0032695)5.34234593
13macrophage activation involved in immune response (GO:0002281)5.23904945
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.75775005
15detection of molecule of bacterial origin (GO:0032490)4.69767778
16detection of other organism (GO:0098543)4.64769586
17cellular extravasation (GO:0045123)4.55864957
18detection of bacterium (GO:0016045)4.30819731
19immunoglobulin mediated immune response (GO:0016064)4.29834202
20detection of external biotic stimulus (GO:0098581)4.28925092
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.27596411
22neutrophil activation (GO:0042119)4.12186886
23microglial cell activation (GO:0001774)4.04974605
24granulocyte activation (GO:0036230)4.03788870
25leukocyte aggregation (GO:0070486)3.99889953
26regulation of interferon-beta biosynthetic process (GO:0045357)3.97712920
27antigen processing and presentation of endogenous antigen (GO:0019883)3.97338750
28macrophage activation (GO:0042116)3.96380252
29regulation of mast cell degranulation (GO:0043304)3.94115639
30positive regulation of mast cell activation (GO:0033005)3.93691917
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.92966622
32respiratory burst (GO:0045730)3.92433408
33regulation of B cell receptor signaling pathway (GO:0050855)3.87922304
34regulation of gamma-delta T cell activation (GO:0046643)3.84809945
35myeloid cell activation involved in immune response (GO:0002275)3.84450288
36detection of biotic stimulus (GO:0009595)3.81420965
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.80315882
38response to host immune response (GO:0052572)3.80315882
39lipopolysaccharide-mediated signaling pathway (GO:0031663)3.75484838
40regulation of mast cell activation involved in immune response (GO:0033006)3.64694925
41regulation of myeloid leukocyte mediated immunity (GO:0002886)3.57992282
42positive regulation of mast cell activation involved in immune response (GO:0033008)3.57210733
43positive regulation of mast cell degranulation (GO:0043306)3.57210733
44leukocyte migration involved in inflammatory response (GO:0002523)3.56402079
45regulation of mast cell activation (GO:0033003)3.54690261
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.53891372
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.47611157
48regulation of leukocyte degranulation (GO:0043300)3.44731505
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.44562470
50response to host defenses (GO:0052200)3.42101506
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.42101506
52response to host (GO:0075136)3.42101506
53regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.38490257
54response to muramyl dipeptide (GO:0032495)3.37429477
55neutrophil mediated immunity (GO:0002446)3.27945307
56T-helper 1 type immune response (GO:0042088)3.27846955
57B cell mediated immunity (GO:0019724)3.27300489
58defense response to protozoan (GO:0042832)3.26835068
59positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.26084631
60germinal center formation (GO:0002467)3.25431994
61negative regulation of T cell mediated immunity (GO:0002710)3.24167168
62interferon-gamma-mediated signaling pathway (GO:0060333)3.23702415
63negative regulation of leukocyte mediated immunity (GO:0002704)3.22331322
64production of molecular mediator involved in inflammatory response (GO:0002532)3.21686208
65positive regulation of cellular amide metabolic process (GO:0034250)3.19760923
66regulation of T-helper 2 cell differentiation (GO:0045628)3.18721686
67negative regulation of cytokine production involved in immune response (GO:0002719)3.16586582
68regulation of T cell tolerance induction (GO:0002664)3.15590969
69neutrophil chemotaxis (GO:0030593)3.14224059
70positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.12906364
71regulation of tolerance induction (GO:0002643)3.09859843
72neutrophil migration (GO:1990266)3.06057481
73negative regulation of erythrocyte differentiation (GO:0045647)3.05705435
74type I interferon signaling pathway (GO:0060337)3.04142273
75cellular response to type I interferon (GO:0071357)3.04142273
76myeloid leukocyte activation (GO:0002274)3.02895847
77response to protozoan (GO:0001562)3.01963020
78response to type I interferon (GO:0034340)3.00663922
79regulation of dendritic cell antigen processing and presentation (GO:0002604)2.99862866
80positive regulation of antigen processing and presentation (GO:0002579)2.99425497
81regulation of antigen processing and presentation (GO:0002577)2.99325704
82positive regulation of leukocyte degranulation (GO:0043302)2.98458014
83regulation of gamma-delta T cell differentiation (GO:0045586)2.96533138
84regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.93572199
85leukocyte degranulation (GO:0043299)2.92789178
86regulation of regulated secretory pathway (GO:1903305)2.91552296
87regulation of interferon-alpha production (GO:0032647)2.91203339
88positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.90663620
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90540817
90myeloid leukocyte mediated immunity (GO:0002444)2.90482863
91positive regulation of interferon-alpha production (GO:0032727)2.86789413
92positive regulation of toll-like receptor signaling pathway (GO:0034123)2.80439551
93negative regulation of interleukin-6 production (GO:0032715)2.80200374
94positive regulation of type 2 immune response (GO:0002830)2.79591690
95negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.77152557
96positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.76918636
97granulocyte chemotaxis (GO:0071621)2.76364668
98myeloid dendritic cell differentiation (GO:0043011)2.74919950
99myeloid dendritic cell activation (GO:0001773)2.73423973
100positive regulation of B cell differentiation (GO:0045579)2.72669324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.47034352
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.12151563
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.91707448
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.78851256
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.69077584
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.64579362
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.43332380
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22527497
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.06461479
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.00247035
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73755950
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.72560423
13SPI1_23547873_ChIP-Seq_NB4_Human2.71447450
14* SPI1_23127762_ChIP-Seq_K562_Human2.67010627
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.65372938
16VDR_24763502_ChIP-Seq_THP-1_Human2.65267644
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.64809001
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.60777336
19VDR_21846776_ChIP-Seq_THP-1_Human2.51157673
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44515430
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44230342
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.34707451
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29688977
24RUNX_20019798_ChIP-Seq_JUKART_Human2.29098223
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.27128094
26SCL_19346495_ChIP-Seq_HPC-7_Human2.20547330
27VDR_24787735_ChIP-Seq_THP-1_Human2.17546139
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10115537
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.09935686
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.00103128
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00038507
32MAF_26560356_Chip-Seq_TH1_Human1.97336023
33MYB_26560356_Chip-Seq_TH2_Human1.92578211
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.90254370
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84384046
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.77539319
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73655129
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71983033
39* UTX_26944678_Chip-Seq_JUKART_Human1.69115371
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67296244
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67230358
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65341980
43TCF7_22412390_ChIP-Seq_EML_Mouse1.59104464
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58347758
45MYB_26560356_Chip-Seq_TH1_Human1.57385933
46MYC_22102868_ChIP-Seq_BL_Human1.55333818
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.54670465
48PU_27001747_Chip-Seq_BMDM_Mouse1.52305071
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48174648
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.46019631
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44249353
52KDM2B_26808549_Chip-Seq_DND41_Human1.42118506
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41850019
54MAF_26560356_Chip-Seq_TH2_Human1.40774273
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40354220
56GATA3_27048872_Chip-Seq_THYMUS_Human1.40164626
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39390226
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39220942
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38309428
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37917866
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36140714
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33166908
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32607734
64SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31557711
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31407157
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31295544
67GATA1_22025678_ChIP-Seq_K562_Human1.30312313
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29731639
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25411871
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24785981
71LXR_22292898_ChIP-Seq_THP-1_Human1.23966503
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.22797422
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19700533
74GATA3_26560356_Chip-Seq_TH2_Human1.19478353
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17408349
76GATA1_19941826_ChIP-Seq_K562_Human1.16394299
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15838136
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14774135
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12547176
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.08506343
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06586392
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03720515
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01852665
84BCL6_27268052_Chip-Seq_Bcells_Human1.01318965
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01191015
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99967137
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98923986
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98179991
89BCOR_27268052_Chip-Seq_Bcells_Human0.93104357
90GATA2_19941826_ChIP-Seq_K562_Human0.89620336
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.88074979
92TFEB_21752829_ChIP-Seq_HELA_Human0.84810430
93STAT1_20625510_ChIP-Seq_HELA_Human0.82076574
94SPI1_20517297_ChIP-Seq_HL60_Human0.81094005
95RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80475196
96* NCOR1_26117541_ChIP-Seq_K562_Human0.76679138
97GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76627134
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76454002
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.70484338
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.67668813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.43755046
2MP0003303_peritoneal_inflammation4.11924538
3MP0003436_decreased_susceptibility_to4.01109274
4MP0001835_abnormal_antigen_presentation3.53639391
5MP0006082_CNS_inflammation3.29149803
6MP0002419_abnormal_innate_immunity3.24430961
7MP0009785_altered_susceptibility_to3.10396371
8MP0005671_abnormal_response_to2.94011500
9MP0002148_abnormal_hypersensitivity_rea2.93789984
10MP0005025_abnormal_response_to2.84263544
11MP0005000_abnormal_immune_tolerance2.81919063
12MP0001790_abnormal_immune_system2.74555869
13MP0005387_immune_system_phenotype2.74555869
14MP0005058_abnormal_lysosome_morphology2.67914161
15MP0001800_abnormal_humoral_immune2.54043545
16MP0000685_abnormal_immune_system2.49840252
17MP0003172_abnormal_lysosome_physiology2.48565630
18MP0003191_abnormal_cellular_cholesterol2.46241015
19MP0003300_gastrointestinal_ulcer2.44648312
20MP0002452_abnormal_antigen_presenting2.44530684
21MP0002723_abnormal_immune_serum2.44510827
22MP0002420_abnormal_adaptive_immunity2.25750582
23MP0001819_abnormal_immune_cell2.24096592
24MP0001533_abnormal_skeleton_physiology2.22894922
25MP0005464_abnormal_platelet_physiology2.01454044
26MP0009278_abnormal_bone_marrow2.00654601
27MP0009764_decreased_sensitivity_to1.93358581
28MP0002405_respiratory_system_inflammati1.91596763
29MP0004510_myositis1.88927285
30MP0003075_altered_response_to1.87123509
31MP0001845_abnormal_inflammatory_respons1.84515083
32MP0008260_abnormal_autophagy1.78260907
33MP0000343_altered_response_to1.76869693
34MP0009840_abnormal_foam_cell1.71540800
35MP0004947_skin_inflammation1.69303315
36MP0003828_pulmonary_edema1.67434589
37MP0010155_abnormal_intestine_physiology1.64498902
38MP0000716_abnormal_immune_system1.61885914
39MP0008469_abnormal_protein_level1.60836106
40MP0002998_abnormal_bone_remodeling1.59209653
41MP0000604_amyloidosis1.58591148
42MP0003690_abnormal_glial_cell1.56524399
43MP0005451_abnormal_body_composition1.56135104
44MP0005397_hematopoietic_system_phenotyp1.52684279
45MP0001545_abnormal_hematopoietic_system1.52684279
46MP0005310_abnormal_salivary_gland1.51933718
47MP0002398_abnormal_bone_marrow1.49235865
48MP0000858_altered_metastatic_potential1.45802906
49MP0009333_abnormal_splenocyte_physiolog1.43838044
50MP0001853_heart_inflammation1.33737491
51MP0003806_abnormal_nucleotide_metabolis1.30393821
52MP0000689_abnormal_spleen_morphology1.30135041
53MP0004883_abnormal_blood_vessel1.29391711
54MP0003763_abnormal_thymus_physiology1.29316108
55MP0002277_abnormal_respiratory_mucosa1.27907928
56MP0000465_gastrointestinal_hemorrhage1.27107869
57MP0005166_decreased_susceptibility_to1.25460892
58MP0002429_abnormal_blood_cell1.25263705
59MP0008004_abnormal_stomach_pH1.23669532
60MP0002722_abnormal_immune_system1.22800461
61MP0003183_abnormal_peptide_metabolism1.22009781
62MP0003448_altered_tumor_morphology1.21767569
63MP0002132_abnormal_respiratory_system1.18978748
64MP0005167_abnormal_blood-brain_barrier1.16934778
65MP0005164_abnormal_response_to1.15926327
66MP0001851_eye_inflammation1.08954168
67MP0003656_abnormal_erythrocyte_physiolo1.03906952
68MP0003866_abnormal_defecation1.01634400
69MP0009763_increased_sensitivity_to0.92885205
70MP0005390_skeleton_phenotype0.88689269
71MP0006054_spinal_hemorrhage0.87129156
72MP0000703_abnormal_thymus_morphology0.86678292
73MP0000920_abnormal_myelination0.86384246
74MP0001663_abnormal_digestive_system0.83514820
75MP0004381_abnormal_hair_follicle0.79777222
76MP0003329_amyloid_beta_deposits0.77981187
77MP0003453_abnormal_keratinocyte_physiol0.77231526
78MP0003795_abnormal_bone_structure0.76512509
79MP0002254_reproductive_system_inflammat0.76027440
80MP0002139_abnormal_hepatobiliary_system0.75874845
81MP0009765_abnormal_xenobiotic_induced0.72919149
82MP0002332_abnormal_exercise_endurance0.71800417
83MP0000249_abnormal_blood_vessel0.68227730
84MP0008874_decreased_physiological_sensi0.68110243
85MP0002138_abnormal_hepatobiliary_system0.66021150
86MP0002933_joint_inflammation0.65985859
87MP0000015_abnormal_ear_pigmentation0.61993190
88MP0003091_abnormal_cell_migration0.61131932
89MP0002396_abnormal_hematopoietic_system0.60197934
90MP0004808_abnormal_hematopoietic_stem0.59954373
91MP0000569_abnormal_digit_pigmentation0.59244875
92MP0001873_stomach_inflammation0.57626484
93MP0000371_diluted_coat_color0.57502740
94MP0005319_abnormal_enzyme/_coenzyme0.56259647
95MP0000490_abnormal_crypts_of0.54764828
96MP0000609_abnormal_liver_physiology0.49052130
97MP0003195_calcinosis0.47207469
98MP0003045_fibrosis0.46794032
99MP0003221_abnormal_cardiomyocyte_apopto0.46658673
100MP0001542_abnormal_bone_strength0.45295828

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.22020852
2Recurrent abscess formation (HP:0002722)6.17176911
3Recurrent bacterial skin infections (HP:0005406)6.01831380
4Abnormality of macrophages (HP:0004311)5.88700441
5Recurrent gram-negative bacterial infections (HP:0005420)5.29938098
6Myositis (HP:0100614)5.16821454
7Orchitis (HP:0100796)5.02302295
8Abnormality of liposaccharide metabolism (HP:0010968)4.97446273
9Abnormality of glycosphingolipid metabolism (HP:0004343)4.97446273
10Abnormality of glycolipid metabolism (HP:0010969)4.97446273
11Optic neuritis (HP:0100653)4.77431491
12Retrobulbar optic neuritis (HP:0100654)4.77431491
13Stomatitis (HP:0010280)4.67504127
14Mediastinal lymphadenopathy (HP:0100721)4.15850129
15Increased cerebral lipofuscin (HP:0011813)4.05068302
16Elevated erythrocyte sedimentation rate (HP:0003565)3.90043729
17Chronic obstructive pulmonary disease (HP:0006510)3.82025189
18Obstructive lung disease (HP:0006536)3.82025189
19Recurrent skin infections (HP:0001581)3.74874675
20Recurrent fungal infections (HP:0002841)3.65874458
21Systemic lupus erythematosus (HP:0002725)3.59540311
22Gingivitis (HP:0000230)3.48146935
23Spontaneous hematomas (HP:0007420)3.44138200
24Disinhibition (HP:0000734)3.43230716
25Keratoconjunctivitis sicca (HP:0001097)3.41945377
26Vacuolated lymphocytes (HP:0001922)3.39833537
27Loss of speech (HP:0002371)3.31720190
28Increased neuronal autofluorescent lipopigment (HP:0002074)3.31615647
29Meningitis (HP:0001287)3.31065085
30Gastrointestinal infarctions (HP:0005244)3.27094285
31Keratoconjunctivitis (HP:0001096)3.13935253
32Dysostosis multiplex (HP:0000943)3.12801000
33Amyloidosis (HP:0011034)3.12375496
34Urticaria (HP:0001025)3.10185549
35Chronic mucocutaneous candidiasis (HP:0002728)3.06877132
36Recurrent cutaneous fungal infections (HP:0011370)3.06877132
37Encephalitis (HP:0002383)3.04721328
38Vasculitis (HP:0002633)3.04296618
39Hemoptysis (HP:0002105)2.94171028
40Pulmonary infiltrates (HP:0002113)2.91241670
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.84636485
42Petechiae (HP:0000967)2.76776574
43Mutism (HP:0002300)2.73922791
44Increased IgE level (HP:0003212)2.71806693
45T lymphocytopenia (HP:0005403)2.70912093
46Autoimmune thrombocytopenia (HP:0001973)2.70054649
47Purpura (HP:0000979)2.69505600
48Leukocytosis (HP:0001974)2.65241884
49Episodic fever (HP:0001954)2.64393806
50Prolonged bleeding time (HP:0003010)2.63842911
51Cellulitis (HP:0100658)2.60407498
52Increased serum ferritin (HP:0003281)2.58037443
53Abnormality of T cell number (HP:0011839)2.57985665
54Chest pain (HP:0100749)2.54300461
55Gingival bleeding (HP:0000225)2.52727875
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.50537260
57Arterial thrombosis (HP:0004420)2.48761315
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.46527877
59Abnormality of polysaccharide metabolism (HP:0011012)2.46527877
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.46527877
61Recurrent viral infections (HP:0004429)2.45833819
62Epistaxis (HP:0000421)2.45308341
63Pulmonary embolism (HP:0002204)2.44742387
64Anorexia (HP:0002039)2.43126016
65Increased IgM level (HP:0003496)2.42885928
66Hepatosplenomegaly (HP:0001433)2.34253835
67Abnormality of iron homeostasis (HP:0011031)2.30229873
68Pustule (HP:0200039)2.28907648
69Gangrene (HP:0100758)2.27769018
70Mucopolysacchariduria (HP:0008155)2.26423020
71Urinary glycosaminoglycan excretion (HP:0003541)2.26423020
72Glomerulonephritis (HP:0000099)2.24308201
73Hematochezia (HP:0002573)2.24061426
74Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18708420
75Inflammation of the large intestine (HP:0002037)2.18274341
76Agnosia (HP:0010524)2.14929906
77Peritonitis (HP:0002586)2.14879432
78Osteomyelitis (HP:0002754)2.14669629
79Upper motor neuron abnormality (HP:0002127)2.13115015
80Polyneuropathy (HP:0001271)2.12729135
81Axonal loss (HP:0003447)2.10922089
82Abnormality of the pleura (HP:0002103)2.07736596
83Gastrointestinal inflammation (HP:0004386)2.06051724
84Neuronal loss in central nervous system (HP:0002529)2.05553471
85Vertigo (HP:0002321)2.04455298
86Myocardial infarction (HP:0001658)2.02412018
87Premature loss of primary teeth (HP:0006323)2.01029378
88Hypergammaglobulinemia (HP:0010702)2.00428725
89Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98490382
90Hypochromic anemia (HP:0001931)1.97981796
91Hypochromic microcytic anemia (HP:0004840)1.97143355
92Abnormality of the endocardium (HP:0004306)1.96867860
93Abnormality of T cells (HP:0002843)1.96650727
94Progressive neurologic deterioration (HP:0002344)1.94636578
95Glomerulopathy (HP:0100820)1.94447936
96Granulocytopenia (HP:0001913)1.92016664
97Sepsis (HP:0100806)1.91486959
98Inappropriate behavior (HP:0000719)1.89548158
99Neurofibrillary tangles (HP:0002185)1.88702907
100Acne (HP:0001061)1.88452405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.66346747
2BLK3.74510950
3IRAK43.01184280
4MAP4K13.00975313
5CSK2.93504404
6TYK22.86297788
7MAP2K32.86243039
8ERN12.53101233
9FGR2.35265161
10FES2.30067336
11MAP3K142.25462235
12ZAP702.00383960
13TAOK11.97818971
14IRAK31.97264989
15PRPF4B1.97183412
16MAP3K31.95908068
17MAP3K111.90353980
18JAK31.81198763
19TNK21.77846265
20TXK1.74371391
21MATK1.73953509
22TGFBR21.69957718
23TBK11.69052828
24SYK1.63605031
25GRK71.57405715
26HCK1.53524721
27IKBKE1.53243157
28BTK1.51357961
29EPHB11.50524163
30GRK61.49622416
31CSF1R1.48911004
32LYN1.43973989
33MAP3K131.41908493
34TAOK21.40726780
35JAK21.37493121
36MAP3K11.34477372
37JAK11.30321344
38IKBKB1.27002412
39TAOK31.17544504
40SIK31.16908155
41LCK1.12153974
42BMPR21.11821098
43MARK31.09824771
44KSR21.06479799
45KIT1.04373517
46IRAK10.99798258
47IRAK20.97148540
48YES10.95804099
49CDC42BPA0.91183614
50NME20.85380414
51CAMKK20.85334727
52PDK10.84478480
53STK100.83908852
54ITK0.83904057
55MARK20.81322768
56MAP3K50.80539188
57PDPK10.79196037
58MOS0.79171144
59TESK20.73757157
60MAP3K60.73513042
61TEC0.72290221
62ACVR1B0.65489664
63PRKD20.60282476
64DAPK20.59025483
65FYN0.58877946
66MAP3K20.58452529
67DDR20.57413271
68MAP2K60.55723108
69SIK20.55645937
70MAPK120.53975656
71RPS6KL10.52486046
72RPS6KC10.52486046
73PTK60.52386525
74PIK3CG0.51604582
75KSR10.51152549
76EPHA30.51026518
77MAPK70.50671380
78CAMK1D0.49906312
79MAP2K40.48753301
80PIM10.45329326
81SGK30.45102503
82RPS6KA60.43709417
83CHUK0.40366892
84DYRK1B0.39249135
85PRKCQ0.38968188
86LRRK20.36690831
87RIPK10.36068299
88HIPK20.34122693
89ABL10.33333482
90STK110.33292191
91MAPKAPK20.32412588
92CDK190.31059783
93PRKCD0.30955690
94FGFR30.30772553
95CAMKK10.30542260
96ADRBK20.30285209
97RAF10.29908297
98TRIB30.29768856
99PTK2B0.29252175
100CDK60.29068234

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.36609769
2Osteoclast differentiation_Homo sapiens_hsa043803.15049999
3Leishmaniasis_Homo sapiens_hsa051403.13763833
4Tuberculosis_Homo sapiens_hsa051522.41486203
5Allograft rejection_Homo sapiens_hsa053302.39104568
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.35633219
7Graft-versus-host disease_Homo sapiens_hsa053322.34942382
8Other glycan degradation_Homo sapiens_hsa005112.31816210
9Malaria_Homo sapiens_hsa051442.15489795
10Autoimmune thyroid disease_Homo sapiens_hsa053202.10375753
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08825851
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.08772920
13Lysosome_Homo sapiens_hsa041421.99375088
14Legionellosis_Homo sapiens_hsa051341.97399326
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96545427
16Rheumatoid arthritis_Homo sapiens_hsa053231.94180087
17B cell receptor signaling pathway_Homo sapiens_hsa046621.87091445
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.81835378
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80700900
20Asthma_Homo sapiens_hsa053101.79014649
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.77750794
22Type I diabetes mellitus_Homo sapiens_hsa049401.74923221
23Phagosome_Homo sapiens_hsa041451.74247996
24Pertussis_Homo sapiens_hsa051331.67841218
25Antigen processing and presentation_Homo sapiens_hsa046121.67169682
26Hematopoietic cell lineage_Homo sapiens_hsa046401.67087442
27Toxoplasmosis_Homo sapiens_hsa051451.56922766
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.56887697
29Chemokine signaling pathway_Homo sapiens_hsa040621.54444420
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52546838
31TNF signaling pathway_Homo sapiens_hsa046681.51557670
32Influenza A_Homo sapiens_hsa051641.46627449
33Measles_Homo sapiens_hsa051621.45045058
34Viral myocarditis_Homo sapiens_hsa054161.44983094
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38436142
36Salmonella infection_Homo sapiens_hsa051321.37084702
37Primary immunodeficiency_Homo sapiens_hsa053401.36129060
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34347912
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.34156609
40Acute myeloid leukemia_Homo sapiens_hsa052211.31285881
41African trypanosomiasis_Homo sapiens_hsa051431.29808511
42T cell receptor signaling pathway_Homo sapiens_hsa046601.21242835
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19700075
44Herpes simplex infection_Homo sapiens_hsa051681.17700544
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.13689819
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07417345
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05167696
48Shigellosis_Homo sapiens_hsa051311.00729937
49Hepatitis B_Homo sapiens_hsa051610.99194111
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.96702888
51Hepatitis C_Homo sapiens_hsa051600.94462563
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93885818
53Platelet activation_Homo sapiens_hsa046110.91843806
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90661157
55Apoptosis_Homo sapiens_hsa042100.86482099
56Collecting duct acid secretion_Homo sapiens_hsa049660.80160512
57Amoebiasis_Homo sapiens_hsa051460.79430319
58VEGF signaling pathway_Homo sapiens_hsa043700.74207585
59Non-small cell lung cancer_Homo sapiens_hsa052230.72907780
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.72017765
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71877886
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68473922
63Prolactin signaling pathway_Homo sapiens_hsa049170.68205784
64Complement and coagulation cascades_Homo sapiens_hsa046100.66959871
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.65568500
66Pancreatic cancer_Homo sapiens_hsa052120.65389675
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64702751
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.63982674
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63600171
70Endocytosis_Homo sapiens_hsa041440.60852538
71Chronic myeloid leukemia_Homo sapiens_hsa052200.59060444
72Prion diseases_Homo sapiens_hsa050200.58139673
73Epstein-Barr virus infection_Homo sapiens_hsa051690.57640209
74Renal cell carcinoma_Homo sapiens_hsa052110.57387288
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.51028946
76Bladder cancer_Homo sapiens_hsa052190.49697741
77HIF-1 signaling pathway_Homo sapiens_hsa040660.48623880
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47955728
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47848742
80Notch signaling pathway_Homo sapiens_hsa043300.47271880
81GnRH signaling pathway_Homo sapiens_hsa049120.44483219
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44481454
83Type II diabetes mellitus_Homo sapiens_hsa049300.44083019
84FoxO signaling pathway_Homo sapiens_hsa040680.41757129
85Dorso-ventral axis formation_Homo sapiens_hsa043200.40894986
86Viral carcinogenesis_Homo sapiens_hsa052030.38214030
87HTLV-I infection_Homo sapiens_hsa051660.37142199
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35702090
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32884833
90Insulin resistance_Homo sapiens_hsa049310.32440700
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31989659
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31592789
93MAPK signaling pathway_Homo sapiens_hsa040100.30619289
94Galactose metabolism_Homo sapiens_hsa000520.29666012
95Endometrial cancer_Homo sapiens_hsa052130.29132589
96mTOR signaling pathway_Homo sapiens_hsa041500.27945380
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27594877
98Choline metabolism in cancer_Homo sapiens_hsa052310.27581243
99Rap1 signaling pathway_Homo sapiens_hsa040150.27449265
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27285623

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