SIGLEC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.64044292
2negative regulation of cell killing (GO:0031342)5.47729623
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.47729623
4positive regulation by symbiont of host defense response (GO:0052509)5.41828686
5modulation by symbiont of host defense response (GO:0052031)5.41828686
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.41828686
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.41828686
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.41828686
9modulation by symbiont of host immune response (GO:0052553)5.41828686
10response to peptidoglycan (GO:0032494)5.13003065
11macrophage activation involved in immune response (GO:0002281)5.11144271
12positive regulation of gamma-delta T cell activation (GO:0046645)5.02363311
13negative regulation of interleukin-12 production (GO:0032695)4.96949228
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.71072640
15detection of other organism (GO:0098543)4.42600076
16regulation of interferon-beta biosynthetic process (GO:0045357)4.39675307
17cellular extravasation (GO:0045123)4.21034328
18detection of bacterium (GO:0016045)4.19365485
19immunoglobulin mediated immune response (GO:0016064)4.15812843
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.10706047
21antigen processing and presentation of endogenous antigen (GO:0019883)4.10606605
22neutrophil activation (GO:0042119)4.07786195
23granulocyte activation (GO:0036230)4.05680527
24regulation of mast cell degranulation (GO:0043304)4.00133317
25regulation of gamma-delta T cell activation (GO:0046643)3.98616881
26regulation of B cell receptor signaling pathway (GO:0050855)3.98458041
27negative regulation of type 2 immune response (GO:0002829)3.93371799
28detection of molecule of bacterial origin (GO:0032490)3.90845454
29detection of external biotic stimulus (GO:0098581)3.89647685
30microglial cell activation (GO:0001774)3.87202314
31leukocyte aggregation (GO:0070486)3.84500856
32positive regulation of mast cell activation (GO:0033005)3.79026834
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.78084859
34myeloid cell activation involved in immune response (GO:0002275)3.70702630
35macrophage activation (GO:0042116)3.68036072
36regulation of mast cell activation involved in immune response (GO:0033006)3.68028775
37response to muramyl dipeptide (GO:0032495)3.61211871
38respiratory burst (GO:0045730)3.60384131
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.54421736
40response to host immune response (GO:0052572)3.54421736
41lipopolysaccharide-mediated signaling pathway (GO:0031663)3.53355957
42regulation of myeloid leukocyte mediated immunity (GO:0002886)3.53026174
43regulation of mast cell activation (GO:0033003)3.51817333
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.51292027
45positive regulation of mast cell degranulation (GO:0043306)3.50095509
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.50095509
47regulation of leukocyte degranulation (GO:0043300)3.48768824
48detection of biotic stimulus (GO:0009595)3.47700207
49regulation of gamma-delta T cell differentiation (GO:0045586)3.35499935
50positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.31988200
51negative regulation of lymphocyte mediated immunity (GO:0002707)3.31694211
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.25813190
53interferon-gamma-mediated signaling pathway (GO:0060333)3.18170052
54regulation of interferon-alpha production (GO:0032647)3.16289781
55response to host (GO:0075136)3.14983577
56response to host defenses (GO:0052200)3.14983577
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14983577
58negative regulation of leukocyte mediated immunity (GO:0002704)3.13955415
59regulation of type 2 immune response (GO:0002828)3.12369569
60negative regulation of T cell mediated immunity (GO:0002710)3.12017126
61defense response to protozoan (GO:0042832)3.11491511
62positive regulation of interferon-alpha production (GO:0032727)3.11275342
63negative regulation of cytokine production involved in immune response (GO:0002719)3.10422769
64B cell mediated immunity (GO:0019724)3.10040067
65positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.08075867
66negative regulation of innate immune response (GO:0045824)3.04910420
67leukocyte migration involved in inflammatory response (GO:0002523)3.03108205
68positive regulation of antigen processing and presentation (GO:0002579)3.02363986
69neutrophil mediated immunity (GO:0002446)3.00114043
70leukocyte degranulation (GO:0043299)2.99842205
71regulation of regulated secretory pathway (GO:1903305)2.99225025
72positive regulation of leukocyte degranulation (GO:0043302)2.99206389
73regulation of tolerance induction (GO:0002643)2.98484530
74regulation of T cell tolerance induction (GO:0002664)2.97126393
75production of molecular mediator involved in inflammatory response (GO:0002532)2.96974987
76germinal center formation (GO:0002467)2.96817261
77cellular response to type I interferon (GO:0071357)2.95777241
78type I interferon signaling pathway (GO:0060337)2.95777241
79regulation of T-helper 2 cell differentiation (GO:0045628)2.94609118
80T-helper 1 type immune response (GO:0042088)2.94275667
81neutrophil chemotaxis (GO:0030593)2.94180964
82response to type I interferon (GO:0034340)2.92448301
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92210635
84response to interleukin-15 (GO:0070672)2.91863463
85positive regulation of B cell differentiation (GO:0045579)2.91271379
86amino sugar catabolic process (GO:0046348)2.90938993
87regulation of antigen processing and presentation (GO:0002577)2.90367089
88response to protozoan (GO:0001562)2.90119123
89negative regulation of interleukin-6 production (GO:0032715)2.89881632
90myeloid leukocyte activation (GO:0002274)2.87817564
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87430290
92cellular response to interleukin-15 (GO:0071350)2.87305566
93neutrophil migration (GO:1990266)2.86648784
94positive regulation of T-helper 1 type immune response (GO:0002827)2.83862334
95positive thymic T cell selection (GO:0045059)2.82670688
96positive regulation of cellular amide metabolic process (GO:0034250)2.82070982
97regulation of T cell mediated cytotoxicity (GO:0001914)2.81967845
98hydrogen peroxide biosynthetic process (GO:0050665)2.79980321
99regulation of interleukin-8 biosynthetic process (GO:0045414)2.77782824
100N-acetylneuraminate metabolic process (GO:0006054)2.74966452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.41272350
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.78356342
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.54463738
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.62201863
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56117412
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.55032910
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.25254948
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17106419
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.00101222
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.81714753
11VDR_21846776_ChIP-Seq_THP-1_Human2.81552147
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.79206052
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.65013229
14SPI1_23547873_ChIP-Seq_NB4_Human2.60548042
15VDR_24763502_ChIP-Seq_THP-1_Human2.59649929
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.50472765
17SPI1_23127762_ChIP-Seq_K562_Human2.50168797
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47432690
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.36953717
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.36894503
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35562113
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.32627279
23RUNX_20019798_ChIP-Seq_JUKART_Human2.29074846
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26984986
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.24552265
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.13604538
27VDR_24787735_ChIP-Seq_THP-1_Human2.06870710
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05347300
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05153583
30SCL_19346495_ChIP-Seq_HPC-7_Human2.02087338
31MAF_26560356_Chip-Seq_TH1_Human1.98333878
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.97399147
33MYB_26560356_Chip-Seq_TH2_Human1.95926564
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83069810
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80744896
36UTX_26944678_Chip-Seq_JUKART_Human1.73755282
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.73199421
38GATA1_22025678_ChIP-Seq_K562_Human1.73039315
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.73001164
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.70743788
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68639105
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65780153
43TCF7_22412390_ChIP-Seq_EML_Mouse1.55161975
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.50783552
45MAF_26560356_Chip-Seq_TH2_Human1.50607544
46CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49290781
47PU_27001747_Chip-Seq_BMDM_Mouse1.47154335
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46093634
49MYB_26560356_Chip-Seq_TH1_Human1.45600350
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45184511
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44715974
52LXR_22292898_ChIP-Seq_THP-1_Human1.44526356
53MYC_22102868_ChIP-Seq_BL_Human1.44278137
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44100921
55PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41146697
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40827268
57GATA3_27048872_Chip-Seq_THYMUS_Human1.38765387
58KDM2B_26808549_Chip-Seq_DND41_Human1.38653225
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36440354
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36209247
61GATA3_26560356_Chip-Seq_TH2_Human1.35708040
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35528887
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32959644
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31770452
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29962086
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27174028
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.27103682
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25207855
69BCL6_27268052_Chip-Seq_Bcells_Human1.22820200
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21395035
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19646665
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19069340
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17715610
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14966624
75GATA1_19941826_ChIP-Seq_K562_Human1.14564751
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13429889
77* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12070530
78* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11742269
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11307940
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10784139
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.09647223
82BCOR_27268052_Chip-Seq_Bcells_Human1.08501473
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07619423
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03237767
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00854898
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99599050
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.99346406
88SPI1_20517297_ChIP-Seq_HL60_Human0.93120371
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92774500
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92428592
91CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88216809
92GATA2_19941826_ChIP-Seq_K562_Human0.86907080
93KDM2B_26808549_Chip-Seq_JURKAT_Human0.83002903
94TFEB_21752829_ChIP-Seq_HELA_Human0.82647252
95EGR1_19032775_ChIP-ChIP_M12_Human0.80851762
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80152307
97STAT1_20625510_ChIP-Seq_HELA_Human0.79965057
98ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78662720
99P300_27268052_Chip-Seq_Bcells_Human0.77166660
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.76495906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.30453927
2MP0003303_peritoneal_inflammation4.20388817
3MP0003436_decreased_susceptibility_to4.07290153
4MP0001835_abnormal_antigen_presentation3.54217764
5MP0005671_abnormal_response_to3.35087714
6MP0006082_CNS_inflammation3.28515557
7MP0002419_abnormal_innate_immunity3.21876215
8MP0009785_altered_susceptibility_to3.05589276
9MP0005000_abnormal_immune_tolerance2.92889887
10MP0002148_abnormal_hypersensitivity_rea2.90244790
11MP0005025_abnormal_response_to2.87097947
12MP0005058_abnormal_lysosome_morphology2.82148853
13MP0005387_immune_system_phenotype2.69517112
14MP0001790_abnormal_immune_system2.69517112
15MP0001800_abnormal_humoral_immune2.57419504
16MP0002723_abnormal_immune_serum2.53126601
17MP0002452_abnormal_antigen_presenting2.48881877
18MP0000685_abnormal_immune_system2.45916630
19MP0002420_abnormal_adaptive_immunity2.33689224
20MP0001819_abnormal_immune_cell2.32151942
21MP0001533_abnormal_skeleton_physiology2.26818342
22MP0003300_gastrointestinal_ulcer2.22265874
23MP0003172_abnormal_lysosome_physiology2.19644327
24MP0009278_abnormal_bone_marrow2.19564764
25MP0003191_abnormal_cellular_cholesterol2.17151147
26MP0009840_abnormal_foam_cell2.08860120
27MP0009764_decreased_sensitivity_to2.03001221
28MP0002405_respiratory_system_inflammati1.95601139
29MP0005464_abnormal_platelet_physiology1.85330223
30MP0001845_abnormal_inflammatory_respons1.84573551
31MP0004947_skin_inflammation1.72140089
32MP0002998_abnormal_bone_remodeling1.69837789
33MP0004510_myositis1.69679237
34MP0003075_altered_response_to1.68917275
35MP0010155_abnormal_intestine_physiology1.68544662
36MP0000716_abnormal_immune_system1.68215553
37MP0000343_altered_response_to1.63536196
38MP0003828_pulmonary_edema1.59073087
39MP0000604_amyloidosis1.59043686
40MP0008469_abnormal_protein_level1.58551882
41MP0000858_altered_metastatic_potential1.57644035
42MP0002398_abnormal_bone_marrow1.52388061
43MP0001545_abnormal_hematopoietic_system1.49309475
44MP0005397_hematopoietic_system_phenotyp1.49309475
45MP0003690_abnormal_glial_cell1.49140056
46MP0003183_abnormal_peptide_metabolism1.47627874
47MP0003763_abnormal_thymus_physiology1.46496244
48MP0009333_abnormal_splenocyte_physiolog1.45213207
49MP0005310_abnormal_salivary_gland1.39432423
50MP0001853_heart_inflammation1.37435097
51MP0001851_eye_inflammation1.36374816
52MP0000689_abnormal_spleen_morphology1.35805016
53MP0000465_gastrointestinal_hemorrhage1.35444320
54MP0005451_abnormal_body_composition1.34130006
55MP0003806_abnormal_nucleotide_metabolis1.31507057
56MP0002429_abnormal_blood_cell1.28742321
57MP0002722_abnormal_immune_system1.27523520
58MP0003448_altered_tumor_morphology1.27158594
59MP0008260_abnormal_autophagy1.23498584
60MP0005166_decreased_susceptibility_to1.22075197
61MP0002332_abnormal_exercise_endurance1.10705198
62MP0008004_abnormal_stomach_pH1.09777056
63MP0005167_abnormal_blood-brain_barrier1.03724665
64MP0004883_abnormal_blood_vessel1.00787017
65MP0002877_abnormal_melanocyte_morpholog1.00753441
66MP0002277_abnormal_respiratory_mucosa1.00682720
67MP0009763_increased_sensitivity_to0.95943976
68MP0002132_abnormal_respiratory_system0.92649126
69MP0005390_skeleton_phenotype0.91971168
70MP0000703_abnormal_thymus_morphology0.90533434
71MP0005164_abnormal_response_to0.90441619
72MP0003866_abnormal_defecation0.86474961
73MP0001873_stomach_inflammation0.86282175
74MP0002139_abnormal_hepatobiliary_system0.86063242
75MP0001663_abnormal_digestive_system0.85217052
76MP0003656_abnormal_erythrocyte_physiolo0.84214594
77MP0000920_abnormal_myelination0.78215677
78MP0003795_abnormal_bone_structure0.77317860
79MP0009765_abnormal_xenobiotic_induced0.76992641
80MP0002933_joint_inflammation0.76978309
81MP0003453_abnormal_keratinocyte_physiol0.73518386
82MP0003329_amyloid_beta_deposits0.73212583
83MP0003195_calcinosis0.71386129
84MP0004782_abnormal_surfactant_physiolog0.69798220
85MP0002133_abnormal_respiratory_system0.65273718
86MP0005388_respiratory_system_phenotype0.65273718
87MP0000490_abnormal_crypts_of0.65116147
88MP0000249_abnormal_blood_vessel0.64191846
89MP0008874_decreased_physiological_sensi0.64157072
90MP0002254_reproductive_system_inflammat0.61883133
91MP0002653_abnormal_ependyma_morphology0.61810178
92MP0005319_abnormal_enzyme/_coenzyme0.60083281
93MP0002138_abnormal_hepatobiliary_system0.59704426
94MP0005365_abnormal_bile_salt0.59490558
95MP0006054_spinal_hemorrhage0.55575330
96MP0005381_digestive/alimentary_phenotyp0.54989506
97MP0000371_diluted_coat_color0.53815525
98MP0003011_delayed_dark_adaptation0.53543079
99MP0004381_abnormal_hair_follicle0.51038538
100MP0000609_abnormal_liver_physiology0.49524424

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycosphingolipid metabolism (HP:0004343)6.03352851
2Abnormality of glycolipid metabolism (HP:0010969)6.03352851
3Abnormality of liposaccharide metabolism (HP:0010968)6.03352851
4Eczematoid dermatitis (HP:0000976)6.01119739
5Abnormality of macrophages (HP:0004311)5.81521708
6Recurrent abscess formation (HP:0002722)5.72182170
7Recurrent bacterial skin infections (HP:0005406)5.47701506
8Myositis (HP:0100614)4.79812112
9Recurrent gram-negative bacterial infections (HP:0005420)4.68392722
10Orchitis (HP:0100796)4.64506760
11Stomatitis (HP:0010280)4.55319004
12Retrobulbar optic neuritis (HP:0100654)4.52194014
13Optic neuritis (HP:0100653)4.52194014
14Increased cerebral lipofuscin (HP:0011813)4.15229279
15Mediastinal lymphadenopathy (HP:0100721)3.93919661
16Vacuolated lymphocytes (HP:0001922)3.76312408
17Elevated erythrocyte sedimentation rate (HP:0003565)3.70264963
18Obstructive lung disease (HP:0006536)3.69486559
19Chronic obstructive pulmonary disease (HP:0006510)3.69486559
20Gastrointestinal infarctions (HP:0005244)3.64882800
21Dysostosis multiplex (HP:0000943)3.59932394
22Systemic lupus erythematosus (HP:0002725)3.49882945
23Loss of speech (HP:0002371)3.47430430
24Recurrent fungal infections (HP:0002841)3.45318075
25Increased neuronal autofluorescent lipopigment (HP:0002074)3.44984778
26Disinhibition (HP:0000734)3.39361784
27Recurrent skin infections (HP:0001581)3.38905272
28Meningitis (HP:0001287)3.20503235
29Spontaneous hematomas (HP:0007420)3.19639684
30Keratoconjunctivitis sicca (HP:0001097)3.15358676
31Encephalitis (HP:0002383)3.05264846
32Vasculitis (HP:0002633)2.99654072
33Gingivitis (HP:0000230)2.99526697
34Urticaria (HP:0001025)2.99275405
35Pulmonary infiltrates (HP:0002113)2.95664014
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.94936652
37Keratoconjunctivitis (HP:0001096)2.93308598
38Amyloidosis (HP:0011034)2.91394913
39Hemoptysis (HP:0002105)2.88906994
40Anorexia (HP:0002039)2.81796416
41T lymphocytopenia (HP:0005403)2.78797231
42Recurrent cutaneous fungal infections (HP:0011370)2.78674559
43Chronic mucocutaneous candidiasis (HP:0002728)2.78674559
44Purpura (HP:0000979)2.77572857
45Petechiae (HP:0000967)2.76998603
46Mutism (HP:0002300)2.76804441
47Increased IgM level (HP:0003496)2.71445293
48Autoimmune thrombocytopenia (HP:0001973)2.64906628
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.63537935
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.63085075
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.63085075
52Abnormality of polysaccharide metabolism (HP:0011012)2.63085075
53Abnormality of T cell number (HP:0011839)2.61078834
54Axonal loss (HP:0003447)2.57946245
55Increased IgE level (HP:0003212)2.56833785
56Increased serum ferritin (HP:0003281)2.55721343
57Hepatosplenomegaly (HP:0001433)2.54025091
58Basal ganglia calcification (HP:0002135)2.51682199
59Leukocytosis (HP:0001974)2.48508793
60Urinary glycosaminoglycan excretion (HP:0003541)2.45372691
61Mucopolysacchariduria (HP:0008155)2.45372691
62Chest pain (HP:0100749)2.36243684
63Pulmonary embolism (HP:0002204)2.33957885
64Episodic fever (HP:0001954)2.32929149
65Arterial thrombosis (HP:0004420)2.31041203
66Malnutrition (HP:0004395)2.30107260
67Cheilitis (HP:0100825)2.28813189
68Gangrene (HP:0100758)2.28734067
69Pustule (HP:0200039)2.28286750
70Prolonged bleeding time (HP:0003010)2.26597637
71Neurofibrillary tangles (HP:0002185)2.24910896
72Agnosia (HP:0010524)2.24177272
73Progressive neurologic deterioration (HP:0002344)2.23842836
74Recurrent viral infections (HP:0004429)2.23787668
75Upper motor neuron abnormality (HP:0002127)2.22892397
76Gingival bleeding (HP:0000225)2.22097468
77Personality changes (HP:0000751)2.21787361
78Epistaxis (HP:0000421)2.19121215
79Neuronal loss in central nervous system (HP:0002529)2.17826749
80Premature loss of primary teeth (HP:0006323)2.17758727
81Abnormality of iron homeostasis (HP:0011031)2.17090199
82Abnormality of eosinophils (HP:0001879)2.16831403
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16425447
84Inflammation of the large intestine (HP:0002037)2.16076799
85Hypergammaglobulinemia (HP:0010702)2.15763739
86Cellulitis (HP:0100658)2.15477321
87Glomerulonephritis (HP:0000099)2.14488485
88Granulocytopenia (HP:0001913)2.13423808
89Abnormality of T cells (HP:0002843)2.09701413
90Hypochromic anemia (HP:0001931)2.08300510
91Polyneuropathy (HP:0001271)2.07014545
92Gastrointestinal inflammation (HP:0004386)2.03736145
93Vertigo (HP:0002321)2.03259746
94Osteomyelitis (HP:0002754)1.99523675
95Hematochezia (HP:0002573)1.98799859
96Myocardial infarction (HP:0001658)1.97672052
97Glomerulopathy (HP:0100820)1.97595711
98Abnormality of the endocardium (HP:0004306)1.95211828
99Abnormality of the pleura (HP:0002103)1.94546872
100Pathologic fracture (HP:0002756)1.93598413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.72877246
2BLK3.73773713
3MAP4K12.95449447
4IRAK42.78324769
5CSK2.77898644
6TYK22.59105490
7MAP3K142.53781923
8MAP2K32.46059045
9FES2.34490633
10IRAK32.31705814
11TXK2.31293991
12GRK62.21782831
13ERN12.19273117
14FGR2.18194738
15ZAP702.02331266
16TBK12.00448626
17TNK21.94462878
18PRPF4B1.87550626
19MAP3K31.83592121
20IKBKE1.80001116
21TGFBR21.72894413
22BTK1.72247352
23TAOK11.70590553
24JAK31.69572556
25MAP3K111.67964529
26MATK1.67673998
27TAOK31.65162090
28SYK1.64363616
29IKBKB1.61798564
30GRK71.60160768
31HCK1.58359602
32LYN1.47640905
33JAK11.47297085
34TAOK21.45526869
35BMPR21.45294984
36CSF1R1.42574718
37LCK1.29101802
38KIT1.24877386
39MAP3K131.23765886
40MARK31.16333355
41JAK21.12172311
42EPHB11.05254146
43MAP3K11.03902906
44SIK31.02996200
45TESK20.99324544
46STK100.85831254
47PDK10.81915783
48MOS0.81063738
49MUSK0.80949898
50IRAK20.80752417
51ITK0.77952449
52CDC42BPA0.76160369
53KSR20.76119075
54NME20.75348729
55CAMKK20.73865255
56PDPK10.73268530
57RPS6KC10.70583582
58RPS6KL10.70583582
59MAP2K20.69932231
60PIM10.69625737
61IRAK10.69296500
62TEC0.67558749
63YES10.67426427
64PRKD20.66319866
65RPS6KA60.62492984
66DAPK20.62240923
67MAPK70.60803967
68RPS6KA20.60417793
69FYN0.60090165
70MAP3K50.59924399
71MAP3K60.56424292
72MARK20.54696923
73SIK20.53144263
74ACVR1B0.51755495
75TLK10.51468489
76MAPK120.49350629
77SGK30.45859711
78ADRBK20.45850603
79DDR20.45217100
80MAP2K60.44604257
81PRKCQ0.43048409
82ABL10.41597392
83CHUK0.37700779
84ABL20.37276448
85CDK40.36479082
86CAMK1D0.35289171
87RPS6KA10.34895325
88LRRK20.33309051
89CDK60.32891792
90MAPK40.32758696
91PRKCD0.32421606
92PTK60.31491070
93ARAF0.30604062
94STK110.30266991
95SGK20.29707815
96PIK3CG0.29697631
97MAPKAPK20.27922799
98MAP3K20.27249098
99INSR0.23906967
100EGFR0.23008358

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.24728516
2Osteoclast differentiation_Homo sapiens_hsa043803.06816105
3Leishmaniasis_Homo sapiens_hsa051403.04518102
4Allograft rejection_Homo sapiens_hsa053302.59122007
5Graft-versus-host disease_Homo sapiens_hsa053322.58681308
6Other glycan degradation_Homo sapiens_hsa005112.52213894
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.34546003
8Tuberculosis_Homo sapiens_hsa051522.28585176
9Autoimmune thyroid disease_Homo sapiens_hsa053202.26755009
10Lysosome_Homo sapiens_hsa041422.24955534
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08132784
12Malaria_Homo sapiens_hsa051442.07550828
13Rheumatoid arthritis_Homo sapiens_hsa053232.07375430
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.05512529
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02804656
16Asthma_Homo sapiens_hsa053102.01416831
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.97293464
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87182486
19Type I diabetes mellitus_Homo sapiens_hsa049401.85772490
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.83981111
21Legionellosis_Homo sapiens_hsa051341.83921543
22Antigen processing and presentation_Homo sapiens_hsa046121.81222631
23B cell receptor signaling pathway_Homo sapiens_hsa046621.79280289
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70739580
25Hematopoietic cell lineage_Homo sapiens_hsa046401.67989974
26Phagosome_Homo sapiens_hsa041451.67193513
27Primary immunodeficiency_Homo sapiens_hsa053401.66066420
28Pertussis_Homo sapiens_hsa051331.64043423
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.63373396
30Toxoplasmosis_Homo sapiens_hsa051451.58110096
31Viral myocarditis_Homo sapiens_hsa054161.49959242
32TNF signaling pathway_Homo sapiens_hsa046681.49453526
33Chemokine signaling pathway_Homo sapiens_hsa040621.48867110
34Measles_Homo sapiens_hsa051621.43862700
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43680242
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42362023
37Influenza A_Homo sapiens_hsa051641.38777870
38Salmonella infection_Homo sapiens_hsa051321.31857973
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30444543
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28357347
41Herpes simplex infection_Homo sapiens_hsa051681.20556551
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.19956466
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18386997
44T cell receptor signaling pathway_Homo sapiens_hsa046601.17827924
45African trypanosomiasis_Homo sapiens_hsa051431.17397188
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15126012
47Acute myeloid leukemia_Homo sapiens_hsa052211.12049784
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12029370
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07214571
50Shigellosis_Homo sapiens_hsa051311.01033994
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95262752
52Hepatitis B_Homo sapiens_hsa051610.88000245
53Apoptosis_Homo sapiens_hsa042100.87981698
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83756525
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83518809
56Hepatitis C_Homo sapiens_hsa051600.81752020
57Collecting duct acid secretion_Homo sapiens_hsa049660.81711650
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.79902308
59VEGF signaling pathway_Homo sapiens_hsa043700.71246092
60Platelet activation_Homo sapiens_hsa046110.69628854
61Amoebiasis_Homo sapiens_hsa051460.69063301
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.65024948
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64266885
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.63441539
65Endocytosis_Homo sapiens_hsa041440.60123852
66Ether lipid metabolism_Homo sapiens_hsa005650.56003905
67Complement and coagulation cascades_Homo sapiens_hsa046100.53363647
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52977453
69Epstein-Barr virus infection_Homo sapiens_hsa051690.52373102
70Prolactin signaling pathway_Homo sapiens_hsa049170.49496408
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46496847
72Bladder cancer_Homo sapiens_hsa052190.45473674
73Pancreatic cancer_Homo sapiens_hsa052120.43898606
74Prion diseases_Homo sapiens_hsa050200.43865602
75Non-small cell lung cancer_Homo sapiens_hsa052230.43776529
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.42916067
77Notch signaling pathway_Homo sapiens_hsa043300.40976993
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39532105
79Mineral absorption_Homo sapiens_hsa049780.39525063
80HIF-1 signaling pathway_Homo sapiens_hsa040660.39237209
81Renal cell carcinoma_Homo sapiens_hsa052110.37988240
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.37474164
83Arachidonic acid metabolism_Homo sapiens_hsa005900.36459235
84HTLV-I infection_Homo sapiens_hsa051660.36335303
85Chronic myeloid leukemia_Homo sapiens_hsa052200.34956492
86GnRH signaling pathway_Homo sapiens_hsa049120.33332666
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33100740
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.31967945
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27859123
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27441509
91Type II diabetes mellitus_Homo sapiens_hsa049300.27160577
92Galactose metabolism_Homo sapiens_hsa000520.27117400
93Viral carcinogenesis_Homo sapiens_hsa052030.26875786
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26149982
95MAPK signaling pathway_Homo sapiens_hsa040100.25145729
96Dorso-ventral axis formation_Homo sapiens_hsa043200.24941214
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24760854
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20086456
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18857540
100Folate biosynthesis_Homo sapiens_hsa007900.18341307

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