SIGLEC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of protein kinase C signaling (GO:0090037)7.36942545
2estrogen biosynthetic process (GO:0006703)7.18184519
3negative regulation of erythrocyte differentiation (GO:0045647)6.04818606
4positive regulation of gamma-delta T cell activation (GO:0046645)5.20290823
5definitive hemopoiesis (GO:0060216)5.14913306
6post-embryonic morphogenesis (GO:0009886)5.01814141
7regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.96562832
8regulation of transforming growth factor beta2 production (GO:0032909)4.93238413
9L-fucose catabolic process (GO:0042355)4.78763279
10fucose catabolic process (GO:0019317)4.78763279
11L-fucose metabolic process (GO:0042354)4.78763279
12cellular hyperosmotic response (GO:0071474)4.72911410
13paraxial mesoderm development (GO:0048339)4.68360637
14desmosome organization (GO:0002934)4.61743264
15lung-associated mesenchyme development (GO:0060484)4.40411712
16positive regulation of insulin receptor signaling pathway (GO:0046628)4.12132928
17regulation of odontogenesis (GO:0042481)4.11785998
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.10939327
19G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.08448230
20regulation of glycogen (starch) synthase activity (GO:2000465)4.03971607
21trophectodermal cell differentiation (GO:0001829)3.99946379
22negative regulation of calcium ion transport into cytosol (GO:0010523)3.97592520
23bundle of His cell to Purkinje myocyte communication (GO:0086069)3.97050451
24regulation of gamma-delta T cell differentiation (GO:0045586)3.96658677
25female pregnancy (GO:0007565)3.91498920
26erythrocyte maturation (GO:0043249)3.86737732
27regulation of response to osmotic stress (GO:0047484)3.84190140
28negative thymic T cell selection (GO:0045060)3.74801498
29regulation of B cell receptor signaling pathway (GO:0050855)3.72650432
30production of molecular mediator involved in inflammatory response (GO:0002532)3.64124540
31regulation of histone H3-K27 methylation (GO:0061085)3.59704461
32B cell receptor signaling pathway (GO:0050853)3.57819555
33cellular response to interleukin-15 (GO:0071350)3.51368818
34regulation of mast cell degranulation (GO:0043304)3.51136847
35auditory receptor cell stereocilium organization (GO:0060088)3.50974346
36negative regulation of stem cell proliferation (GO:2000647)3.49648657
37response to interleukin-15 (GO:0070672)3.47669367
38positive regulation of B cell differentiation (GO:0045579)3.45591497
39hippo signaling (GO:0035329)3.44736841
40negative T cell selection (GO:0043383)3.41784930
41regulation of gamma-delta T cell activation (GO:0046643)3.41466244
42branching involved in salivary gland morphogenesis (GO:0060445)3.34590219
43thymic T cell selection (GO:0045061)3.31712407
44response to follicle-stimulating hormone (GO:0032354)3.28989716
45notochord development (GO:0030903)3.28954412
46negative regulation of myeloid cell apoptotic process (GO:0033033)3.28096067
47cellular response to gamma radiation (GO:0071480)3.28004061
48regulation of mast cell activation involved in immune response (GO:0033006)3.26025501
49positive regulation of mast cell degranulation (GO:0043306)3.25972753
50positive regulation of mast cell activation involved in immune response (GO:0033008)3.25972753
51JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.25460566
52positive regulation of cellular response to insulin stimulus (GO:1900078)3.20033288
53embryonic process involved in female pregnancy (GO:0060136)3.18541259
54histone H3-K4 trimethylation (GO:0080182)3.14918271
55establishment of endothelial barrier (GO:0061028)3.14871662
56Arp2/3 complex-mediated actin nucleation (GO:0034314)3.12755685
57cranial suture morphogenesis (GO:0060363)3.12037823
58regulation of protein kinase C signaling (GO:0090036)3.11910208
59regulation of interleukin-5 production (GO:0032674)3.06451679
60positive regulation of granulocyte differentiation (GO:0030854)3.04798658
61phospholipid scrambling (GO:0017121)3.04550335
62thrombin receptor signaling pathway (GO:0070493)3.04491517
63neutrophil activation involved in immune response (GO:0002283)3.04009806
64hepatocyte apoptotic process (GO:0097284)3.02009560
65fucose metabolic process (GO:0006004)3.01732773
66regulation of erythrocyte differentiation (GO:0045646)3.01247138
67prostate gland growth (GO:0060736)3.01198987
68positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.00115026
69leukocyte aggregation (GO:0070486)2.97969542
70regulation of leukocyte degranulation (GO:0043300)2.97929014
71positive regulation of hormone biosynthetic process (GO:0046886)2.96855827
72positive regulation of megakaryocyte differentiation (GO:0045654)2.91486913
73regulation of B cell differentiation (GO:0045577)2.86407290
74histone H3-K36 demethylation (GO:0070544)2.85518293
75regulation of sister chromatid cohesion (GO:0007063)2.84443311
76natural killer cell differentiation (GO:0001779)2.84370950
77regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.83393665
78regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82757717
79fucosylation (GO:0036065)2.81604205
80vitamin D metabolic process (GO:0042359)2.80353276
81regulation of platelet aggregation (GO:0090330)2.79913712
82cellular zinc ion homeostasis (GO:0006882)2.79087803
83T cell selection (GO:0045058)2.78109314
84hemoglobin metabolic process (GO:0020027)2.77720259
85pH reduction (GO:0045851)2.75671559
86L-alpha-amino acid transmembrane transport (GO:1902475)2.73949565
87positive regulation of transforming growth factor beta production (GO:0071636)2.73944890
88vitamin transmembrane transport (GO:0035461)2.72333580
89exocrine pancreas development (GO:0031017)2.69668664
90positive regulation of mast cell activation (GO:0033005)2.67709613
91osteoblast development (GO:0002076)2.66228364
92negative regulation of neural precursor cell proliferation (GO:2000178)2.65713442
93response to vitamin A (GO:0033189)2.63547248
94phospholipid translocation (GO:0045332)2.62768054
95lipid translocation (GO:0034204)2.62768054
96DNA topological change (GO:0006265)2.62517151
97multi-multicellular organism process (GO:0044706)2.62419222
98polarized epithelial cell differentiation (GO:0030859)2.60781951
99natural killer cell activation involved in immune response (GO:0002323)2.60360405
100regulation of membrane lipid distribution (GO:0097035)2.59362652

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.75240238
2ZNF263_19887448_ChIP-Seq_K562_Human4.50105970
3SCL_19346495_ChIP-Seq_HPC-7_Human3.79989590
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.78514401
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.50379293
6E2F7_22180533_ChIP-Seq_HELA_Human3.14992541
7MYC_22102868_ChIP-Seq_BL_Human2.83884741
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73036096
9VDR_21846776_ChIP-Seq_THP-1_Human2.69578475
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.59428471
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.59428471
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.59428471
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.55472410
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.38170907
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.29912762
16GATA1_22025678_ChIP-Seq_K562_Human2.27395921
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19033669
18TCF7_22412390_ChIP-Seq_EML_Mouse2.17455533
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.13021616
20CDX2_20551321_ChIP-Seq_CACO-2_Human2.10999094
21VDR_24763502_ChIP-Seq_THP-1_Human2.05416913
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00484006
23SPI1_23127762_ChIP-Seq_K562_Human1.92456497
24* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92286528
25RUNX_20019798_ChIP-Seq_JUKART_Human1.91780754
26* GATA1_19941826_ChIP-Seq_K562_Human1.88461372
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82017485
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77635037
29MYB_26560356_Chip-Seq_TH2_Human1.72923832
30UTX_26944678_Chip-Seq_JUKART_Human1.72601506
31KDM2B_26808549_Chip-Seq_DND41_Human1.66527609
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.65518916
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64934970
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63156125
35MAF_26560356_Chip-Seq_TH1_Human1.61417584
36NCOR1_26117541_ChIP-Seq_K562_Human1.57377808
37PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57012643
38* SPI1_23547873_ChIP-Seq_NB4_Human1.53991182
39BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.53854862
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51364252
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.50190169
42MYB_26560356_Chip-Seq_TH1_Human1.47672704
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47525938
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46274713
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44956829
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.44719663
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44534864
48LXR_22292898_ChIP-Seq_THP-1_Human1.44124868
49* GATA2_19941826_ChIP-Seq_K562_Human1.41605676
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41057342
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40647038
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36553538
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35671409
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.33065527
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28464800
56ELF5_23300383_ChIP-Seq_T47D_Human1.27279339
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27237363
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26172935
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.25518422
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25335323
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.22329187
62MAF_26560356_Chip-Seq_TH2_Human1.22314605
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.22135593
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20953201
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.19740665
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19242576
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17894608
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13340831
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13030204
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10920593
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.10506389
72AHR_22903824_ChIP-Seq_MCF-7_Human1.09919953
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09450400
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08093656
75* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07406181
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.06889842
77* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06748067
78GATA6_25053715_ChIP-Seq_YYC3_Human1.06658504
79GATA3_24758297_ChIP-Seq_MCF-7_Human1.05926490
80GATA4_25053715_ChIP-Seq_YYC3_Human1.05167397
81GATA3_27048872_Chip-Seq_THYMUS_Human1.05113342
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02797090
83EGR1_19032775_ChIP-ChIP_M12_Human1.02262822
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01685329
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01192830
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00734064
87RACK7_27058665_Chip-Seq_MCF-7_Human0.99487702
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99147148
89SPI1_20517297_ChIP-Seq_HL60_Human0.97731748
90NANOG_21062744_ChIP-ChIP_HESCs_Human0.97149683
91CIITA_25753668_ChIP-Seq_RAJI_Human0.97074817
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95592585
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92896050
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92685570
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92396317
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90945219
97MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90550036
98SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89933290
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89063153
100KDM2B_26808549_Chip-Seq_K562_Human0.88781190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot7.71554398
2MP0003878_abnormal_ear_physiology7.71554398
3MP0004264_abnormal_extraembryonic_tissu5.88756871
4MP0002396_abnormal_hematopoietic_system3.35886096
5MP0002098_abnormal_vibrissa_morphology3.33380070
6MP0000383_abnormal_hair_follicle2.94119257
7MP0005076_abnormal_cell_differentiation2.51712655
8MP0010678_abnormal_skin_adnexa2.28948207
9MP0009697_abnormal_copulation2.16119143
10MP0003941_abnormal_skin_development2.07105414
11MP0005451_abnormal_body_composition2.07054020
12MP0010307_abnormal_tumor_latency1.98266492
13MP0005464_abnormal_platelet_physiology1.82828949
14MP0010234_abnormal_vibrissa_follicle1.73005424
15MP0000377_abnormal_hair_follicle1.72023729
16MP0000647_abnormal_sebaceous_gland1.70320527
17MP0003567_abnormal_fetal_cardiomyocyte1.66441161
18MP0004947_skin_inflammation1.65659185
19MP0003763_abnormal_thymus_physiology1.61858203
20MP0001835_abnormal_antigen_presentation1.56680302
21MP0008057_abnormal_DNA_replication1.55471827
22MP0004782_abnormal_surfactant_physiolog1.48059617
23MP0003879_abnormal_hair_cell1.46864219
24MP0002998_abnormal_bone_remodeling1.41357813
25MP0002796_impaired_skin_barrier1.38795977
26MP0003300_gastrointestinal_ulcer1.37708659
27MP0004185_abnormal_adipocyte_glucose1.30490864
28MP0001545_abnormal_hematopoietic_system1.29956812
29MP0005397_hematopoietic_system_phenotyp1.29956812
30MP0004019_abnormal_vitamin_homeostasis1.28003198
31MP0002163_abnormal_gland_morphology1.24288891
32MP0002398_abnormal_bone_marrow1.23522080
33MP0003693_abnormal_embryo_hatching1.20289122
34MP0009333_abnormal_splenocyte_physiolog1.20019624
35MP0003890_abnormal_embryonic-extraembry1.19540789
36MP0003436_decreased_susceptibility_to1.16681306
37MP0009115_abnormal_fat_cell1.16033906
38MP0005409_darkened_coat_color1.14782552
39MP0003385_abnormal_body_wall1.11799734
40MP0003183_abnormal_peptide_metabolism1.10966842
41MP0003122_maternal_imprinting1.10670836
42MP0004381_abnormal_hair_follicle1.06553471
43MP0005000_abnormal_immune_tolerance1.05644322
44MP0009703_decreased_birth_body1.02087886
45MP0001819_abnormal_immune_cell1.01719767
46MP0002420_abnormal_adaptive_immunity1.01023907
47MP0002722_abnormal_immune_system1.00935942
48MP0002148_abnormal_hypersensitivity_rea1.00461626
49MP0000703_abnormal_thymus_morphology0.96782106
50MP0001800_abnormal_humoral_immune0.96686345
51MP0002086_abnormal_extraembryonic_tissu0.96525481
52MP0001348_abnormal_lacrimal_gland0.95748339
53MP0001485_abnormal_pinna_reflex0.94271393
54MP0000716_abnormal_immune_system0.92067343
55MP0005666_abnormal_adipose_tissue0.91704086
56MP0008004_abnormal_stomach_pH0.91317722
57MP0002138_abnormal_hepatobiliary_system0.91022378
58MP0004808_abnormal_hematopoietic_stem0.89562961
59MP0002429_abnormal_blood_cell0.87370572
60MP0002419_abnormal_innate_immunity0.87217806
61MP0004957_abnormal_blastocyst_morpholog0.85701836
62MP0000427_abnormal_hair_cycle0.85082186
63MP0000689_abnormal_spleen_morphology0.84588443
64MP0001216_abnormal_epidermal_layer0.83685319
65MP0009931_abnormal_skin_appearance0.83662544
66MP0005025_abnormal_response_to0.83410995
67MP0009278_abnormal_bone_marrow0.82367932
68MP0002723_abnormal_immune_serum0.81539770
69MP0003303_peritoneal_inflammation0.80882974
70MP0000367_abnormal_coat/_hair0.80715826
71MP0005367_renal/urinary_system_phenotyp0.80433884
72MP0000516_abnormal_urinary_system0.80433884
73MP0001919_abnormal_reproductive_system0.79907741
74MP0003959_abnormal_lean_body0.79865627
75MP0002452_abnormal_antigen_presenting0.77966729
76MP0000490_abnormal_crypts_of0.73459721
77MP0005671_abnormal_response_to0.73417959
78MP0005075_abnormal_melanosome_morpholog0.73146224
79MP0001730_embryonic_growth_arrest0.72484363
80MP0003566_abnormal_cell_adhesion0.72102249
81MP0010094_abnormal_chromosome_stability0.71259526
82MP0004742_abnormal_vestibular_system0.70924290
83MP0003123_paternal_imprinting0.69107830
84MP0005387_immune_system_phenotype0.68461363
85MP0001790_abnormal_immune_system0.68461363
86MP0005647_abnormal_sex_gland0.68327667
87MP0009672_abnormal_birth_weight0.68102787
88MP0003828_pulmonary_edema0.67337263
89MP0005375_adipose_tissue_phenotype0.66542343
90MP0003942_abnormal_urinary_system0.65542748
91MP0002127_abnormal_cardiovascular_syste0.65009534
92MP0000350_abnormal_cell_proliferation0.63479426
93MP0001765_abnormal_ion_homeostasis0.62330132
94MP0003077_abnormal_cell_cycle0.62236899
95MP0001293_anophthalmia0.60340236
96MP0002009_preneoplasia0.60263311
97MP0000639_abnormal_adrenal_gland0.59778940
98MP0002877_abnormal_melanocyte_morpholog0.58824122
99MP0005379_endocrine/exocrine_gland_phen0.58811070
100MP0005501_abnormal_skin_physiology0.57920916

Predicted human phenotypes

RankGene SetZ-score
1Bilateral sensorineural hearing impairment (HP:0008619)6.37013983
2Asymmetry of the thorax (HP:0001555)6.02134197
3Abnormality of dental color (HP:0011073)4.76993222
4Curly hair (HP:0002212)4.65684935
5High anterior hairline (HP:0009890)4.56779714
6Bicornuate uterus (HP:0000813)4.02108357
7Right ventricular cardiomyopathy (HP:0011663)3.97542540
8Metaphyseal cupping (HP:0003021)3.86515149
9Myelomeningocele (HP:0002475)3.80497795
10Increased circulating renin level (HP:0000848)3.64132523
11Renal tubular acidosis (HP:0001947)3.62329263
12Paralysis (HP:0003470)3.55986515
13Increased IgE level (HP:0003212)3.48721116
14Abnormality of the fingertips (HP:0001211)3.36446183
15Cone-rod dystrophy (HP:0000548)3.33592368
16Bilateral microphthalmos (HP:0007633)3.31908485
17Absent eyebrow (HP:0002223)3.28687434
18Choanal stenosis (HP:0000452)3.25679833
19Tetany (HP:0001281)3.16615871
20Recurrent viral infections (HP:0004429)3.07500791
21Abnormality of the parietal bone (HP:0002696)3.07233968
22Partial agenesis of the corpus callosum (HP:0001338)3.01705578
23Aplastic anemia (HP:0001915)2.98112406
24Aplasia cutis congenita (HP:0001057)2.87317714
25Central scotoma (HP:0000603)2.85859903
26Pallor (HP:0000980)2.77320681
27Proximal tubulopathy (HP:0000114)2.75740910
28Hypomagnesemia (HP:0002917)2.69870792
29Nephroblastoma (Wilms tumor) (HP:0002667)2.67039636
30Aplasia of the musculature (HP:0100854)2.63518161
31Recurrent fungal infections (HP:0002841)2.60274047
32Eczematoid dermatitis (HP:0000976)2.58788817
33Abnormal lung lobation (HP:0002101)2.57011965
34Prolonged bleeding time (HP:0003010)2.54937713
35Testicular neoplasm (HP:0010788)2.50004355
36Cellulitis (HP:0100658)2.48503763
37Woolly hair (HP:0002224)2.48394036
38Embryonal renal neoplasm (HP:0011794)2.45909278
39Cubitus valgus (HP:0002967)2.34585171
40Acute lymphatic leukemia (HP:0006721)2.33009321
41Absent eyelashes (HP:0000561)2.32203949
42Gastrointestinal inflammation (HP:0004386)2.30910576
43Abnormal auditory evoked potentials (HP:0006958)2.28160996
44Granulocytopenia (HP:0001913)2.23320571
45Abnormality of the pubic bones (HP:0003172)2.22991182
46Inflammation of the large intestine (HP:0002037)2.22398111
47Metaphyseal dysplasia (HP:0100255)2.20150367
48Abnormality of the lacrimal duct (HP:0011481)2.15195374
49Hypoplasia of the iris (HP:0007676)2.15146356
50Annular pancreas (HP:0001734)2.12156155
51Midline defect of the nose (HP:0004122)2.12047683
52Agammaglobulinemia (HP:0004432)2.10717257
53Abnormal foot bone ossification (HP:0010675)2.10442914
54Clitoromegaly (HP:0000057)2.09888750
55Amelogenesis imperfecta (HP:0000705)2.09662870
56Colitis (HP:0002583)2.08779058
57Asymmetric growth (HP:0100555)2.07805571
58Acute myeloid leukemia (HP:0004808)2.07484264
59Basal cell carcinoma (HP:0002671)2.06199400
60Wide intermamillary distance (HP:0006610)2.06196538
61Hypokalemic alkalosis (HP:0001949)2.03934198
62Persistence of primary teeth (HP:0006335)1.99455743
63Abnormal tarsal ossification (HP:0008369)1.98945515
64Vertigo (HP:0002321)1.98676205
65Renal tubular dysfunction (HP:0000124)1.98055641
66Deep palmar crease (HP:0006191)1.96043199
67Morphological abnormality of the middle ear (HP:0008609)1.94389222
68Lymphedema (HP:0001004)1.92649250
69Hypoparathyroidism (HP:0000829)1.91950248
70Recurrent abscess formation (HP:0002722)1.91710047
71Advanced eruption of teeth (HP:0006288)1.91151505
72Bony spicule pigmentary retinopathy (HP:0007737)1.90631635
73Papilloma (HP:0012740)1.90335638
74Verrucae (HP:0200043)1.90335638
75Ridged nail (HP:0001807)1.89552061
76Abnormality of macular pigmentation (HP:0008002)1.88946846
77Concave nail (HP:0001598)1.87437901
78Pustule (HP:0200039)1.84959336
79Chromsome breakage (HP:0040012)1.84461219
80Abnormality of the nasolacrimal system (HP:0000614)1.82976814
81Abnormality of magnesium homeostasis (HP:0004921)1.80771837
82Severe Myopia (HP:0011003)1.80576427
83Long palpebral fissure (HP:0000637)1.79021113
84Accelerated skeletal maturation (HP:0005616)1.78851661
85Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77931237
86Meningocele (HP:0002435)1.77922643
87Recurrent cutaneous fungal infections (HP:0011370)1.77560523
88Chronic mucocutaneous candidiasis (HP:0002728)1.77560523
89Severe short stature (HP:0003510)1.75765966
90Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74619622
91Myelodysplasia (HP:0002863)1.72969416
92Attenuation of retinal blood vessels (HP:0007843)1.72327311
93Ulnar deviation of the wrist (HP:0003049)1.72220353
94Facial hemangioma (HP:0000329)1.70430348
95Delayed epiphyseal ossification (HP:0002663)1.69934915
96Capillary hemangiomas (HP:0005306)1.68415641
97Impulsivity (HP:0100710)1.68180342
98Heterotopia (HP:0002282)1.68134795
99Ankyloglossia (HP:0010296)1.66961144
100Leukocytosis (HP:0001974)1.66682445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS18.77512305
2LATS25.27432180
3STK38L5.26271124
4NME14.41359779
5STK392.96552395
6WNK42.60603326
7OXSR12.32104760
8STK382.20123873
9MAP3K72.07819354
10DAPK22.00237296
11RPS6KA41.97838748
12MAP4K11.93402111
13RIPK41.86980298
14STK31.85171120
15NME21.55082913
16BMPR21.49340214
17MST41.36814095
18EPHA21.34893449
19ZAP701.33501679
20FGFR21.30475853
21PRPF4B1.15496963
22JAK11.15445988
23CDK121.10973268
24CSK1.06558315
25BLK1.06440087
26AKT31.03734612
27STK101.00956386
28KDR0.97442420
29EEF2K0.93923377
30TRPM70.93757991
31PLK40.92979837
32BRD40.89699321
33MAP3K140.79083037
34BTK0.78992189
35CLK10.78577790
36RPS6KB20.76877999
37FGFR30.73929277
38LRRK20.73134638
39MAP3K130.70237091
40SYK0.69126558
41MAP3K100.67340669
42PDGFRA0.64734152
43BMX0.63684806
44MARK20.62440286
45TRIB30.62209873
46NEK20.62158951
47FGFR40.61328208
48DAPK10.60806424
49CSF1R0.58010205
50YES10.56996636
51MAPK110.55621577
52MATK0.55602049
53TYK20.55329557
54PRKCQ0.52725440
55MAPK120.51771895
56RPS6KL10.50784601
57RPS6KC10.50784601
58ICK0.50164576
59STK240.49347815
60TXK0.49246952
61PDGFRB0.48324695
62FGR0.48296539
63HCK0.46812843
64JAK20.45964626
65JAK30.43844936
66RPS6KA20.43178043
67KIT0.43133452
68SIK30.41585760
69RPS6KA60.38930852
70LYN0.38339087
71MARK30.37495398
72NEK90.36812963
73MAP3K10.36719194
74EIF2AK30.36524321
75SCYL20.35438260
76LCK0.33187661
77SIK20.31567769
78RET0.29028037
79FES0.28943101
80GRK60.28483899
81DAPK30.28471993
82MAP2K10.27941611
83CDC42BPA0.27920170
84DYRK1B0.26541645
85CDK60.25991814
86TESK20.25784360
87FGFR10.25474750
88MAP2K30.22123624
89MST1R0.21956985
90TTK0.21630129
91CDK40.21447564
92MAPK30.21352100
93PIM10.20811095
94ITK0.20591167
95MAPK10.20462909
96WEE10.19000440
97MTOR0.18751524
98TEC0.18609664
99TAOK30.18124014
100EPHB10.17618700

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.91848304
2Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.51898251
3Collecting duct acid secretion_Homo sapiens_hsa049662.51479698
4Acute myeloid leukemia_Homo sapiens_hsa052212.19493267
5Jak-STAT signaling pathway_Homo sapiens_hsa046302.06656521
6T cell receptor signaling pathway_Homo sapiens_hsa046601.97974071
7Non-small cell lung cancer_Homo sapiens_hsa052231.80168862
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78297742
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78215767
10Hedgehog signaling pathway_Homo sapiens_hsa043401.72667832
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69266694
12Chronic myeloid leukemia_Homo sapiens_hsa052201.66586848
13Dorso-ventral axis formation_Homo sapiens_hsa043201.63678023
14Endometrial cancer_Homo sapiens_hsa052131.61883615
15Renal cell carcinoma_Homo sapiens_hsa052111.61580167
16Hematopoietic cell lineage_Homo sapiens_hsa046401.61086686
17Asthma_Homo sapiens_hsa053101.53677742
18Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.50350978
19Primary immunodeficiency_Homo sapiens_hsa053401.48258257
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45355606
21Autoimmune thyroid disease_Homo sapiens_hsa053201.44334659
22Ovarian steroidogenesis_Homo sapiens_hsa049131.36328396
23Graft-versus-host disease_Homo sapiens_hsa053321.33789347
24Leishmaniasis_Homo sapiens_hsa051401.32777057
25Pancreatic cancer_Homo sapiens_hsa052121.28280461
26Viral myocarditis_Homo sapiens_hsa054161.26905856
27Thyroid cancer_Homo sapiens_hsa052161.25574112
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.25141219
29Basal cell carcinoma_Homo sapiens_hsa052171.23842704
30Inositol phosphate metabolism_Homo sapiens_hsa005621.22536237
31Osteoclast differentiation_Homo sapiens_hsa043801.17821731
32Influenza A_Homo sapiens_hsa051641.15843490
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14424435
34Vibrio cholerae infection_Homo sapiens_hsa051101.13315110
35Toxoplasmosis_Homo sapiens_hsa051451.09804655
36Sphingolipid signaling pathway_Homo sapiens_hsa040711.08493804
37Tuberculosis_Homo sapiens_hsa051521.06985359
38VEGF signaling pathway_Homo sapiens_hsa043701.06906740
39Hepatitis B_Homo sapiens_hsa051611.04378948
40Choline metabolism in cancer_Homo sapiens_hsa052311.03508560
41HIF-1 signaling pathway_Homo sapiens_hsa040661.02740628
42Hepatitis C_Homo sapiens_hsa051601.02550064
43Herpes simplex infection_Homo sapiens_hsa051681.02541176
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.02173577
45HTLV-I infection_Homo sapiens_hsa051661.01225267
46Allograft rejection_Homo sapiens_hsa053301.00949755
47Measles_Homo sapiens_hsa051621.00466861
48Small cell lung cancer_Homo sapiens_hsa052220.99914192
49Other glycan degradation_Homo sapiens_hsa005110.99690383
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.98743189
51Bladder cancer_Homo sapiens_hsa052190.96941285
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.95538485
53Colorectal cancer_Homo sapiens_hsa052100.92868886
54Notch signaling pathway_Homo sapiens_hsa043300.91209934
55Rheumatoid arthritis_Homo sapiens_hsa053230.90361548
56Antigen processing and presentation_Homo sapiens_hsa046120.90104274
57Adherens junction_Homo sapiens_hsa045200.89944576
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88651671
59Pathways in cancer_Homo sapiens_hsa052000.87963354
60Platelet activation_Homo sapiens_hsa046110.87347860
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84528014
62Prolactin signaling pathway_Homo sapiens_hsa049170.84080651
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83706128
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83088632
65Hippo signaling pathway_Homo sapiens_hsa043900.82835179
66mRNA surveillance pathway_Homo sapiens_hsa030150.82713680
67Ras signaling pathway_Homo sapiens_hsa040140.80207619
68Prostate cancer_Homo sapiens_hsa052150.77621158
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.77299471
70ErbB signaling pathway_Homo sapiens_hsa040120.77065673
71Chemokine signaling pathway_Homo sapiens_hsa040620.75549003
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73579122
73Proteoglycans in cancer_Homo sapiens_hsa052050.72987750
74Endocytosis_Homo sapiens_hsa041440.72216319
75DNA replication_Homo sapiens_hsa030300.69804177
76Apoptosis_Homo sapiens_hsa042100.68415952
77Staphylococcus aureus infection_Homo sapiens_hsa051500.68382836
78Melanogenesis_Homo sapiens_hsa049160.67108842
79Phagosome_Homo sapiens_hsa041450.66887458
80mTOR signaling pathway_Homo sapiens_hsa041500.64272443
81Non-homologous end-joining_Homo sapiens_hsa034500.62964655
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62322863
83MicroRNAs in cancer_Homo sapiens_hsa052060.61839605
84Viral carcinogenesis_Homo sapiens_hsa052030.61395785
85Wnt signaling pathway_Homo sapiens_hsa043100.57729562
86MAPK signaling pathway_Homo sapiens_hsa040100.56710020
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.56074752
88Folate biosynthesis_Homo sapiens_hsa007900.55833843
89Nucleotide excision repair_Homo sapiens_hsa034200.55593488
90GnRH signaling pathway_Homo sapiens_hsa049120.55308606
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54497601
92Insulin signaling pathway_Homo sapiens_hsa049100.53458745
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52629952
94Cell cycle_Homo sapiens_hsa041100.52526351
95Focal adhesion_Homo sapiens_hsa045100.52284733
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.51997668
97Glioma_Homo sapiens_hsa052140.51807873
98Vitamin digestion and absorption_Homo sapiens_hsa049770.50688526
99N-Glycan biosynthesis_Homo sapiens_hsa005100.48392446
100Spliceosome_Homo sapiens_hsa030400.47986995

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