SIGLEC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.15265443
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.15265443
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.15265443
4modulation by symbiont of host immune response (GO:0052553)6.15265443
5positive regulation by symbiont of host defense response (GO:0052509)6.15265443
6modulation by symbiont of host defense response (GO:0052031)6.15265443
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.89468647
8negative regulation of cell killing (GO:0031342)5.89468647
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.80902967
10neutrophil activation involved in immune response (GO:0002283)5.79120770
11detection of other organism (GO:0098543)5.53426601
12positive regulation of gamma-delta T cell activation (GO:0046645)5.45527531
13response to peptidoglycan (GO:0032494)5.37029849
14detection of bacterium (GO:0016045)5.24536404
15macrophage activation involved in immune response (GO:0002281)5.16840742
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.98553803
17antigen processing and presentation of endogenous antigen (GO:0019883)4.91863949
18detection of molecule of bacterial origin (GO:0032490)4.91608233
19leukocyte migration involved in inflammatory response (GO:0002523)4.90642208
20leukocyte aggregation (GO:0070486)4.87460785
21detection of external biotic stimulus (GO:0098581)4.85427016
22negative regulation of interleukin-12 production (GO:0032695)4.75033746
23neutrophil activation (GO:0042119)4.65281435
24cellular extravasation (GO:0045123)4.64806948
25regulation of B cell receptor signaling pathway (GO:0050855)4.64454757
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.55440109
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.46696475
28regulation of interferon-beta biosynthetic process (GO:0045357)4.39788017
29respiratory burst (GO:0045730)4.38832116
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.35833899
31response to host immune response (GO:0052572)4.35833899
32immunoglobulin mediated immune response (GO:0016064)4.30679069
33detection of biotic stimulus (GO:0009595)4.25863906
34granulocyte activation (GO:0036230)4.25401730
35negative regulation of lymphocyte mediated immunity (GO:0002707)4.13636878
36microglial cell activation (GO:0001774)4.09453787
37neutrophil mediated immunity (GO:0002446)4.01384130
38response to host (GO:0075136)3.98644372
39response to host defenses (GO:0052200)3.98644372
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.98644372
41regulation of mast cell degranulation (GO:0043304)3.97318760
42production of molecular mediator involved in inflammatory response (GO:0002532)3.91916752
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91549074
44response to interleukin-15 (GO:0070672)3.90517701
45regulation of gamma-delta T cell activation (GO:0046643)3.89922994
46macrophage activation (GO:0042116)3.86230525
47myeloid cell activation involved in immune response (GO:0002275)3.85826811
48negative regulation of leukocyte mediated immunity (GO:0002704)3.68780650
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.68441945
50regulation of myeloid leukocyte mediated immunity (GO:0002886)3.67081573
51regulation of mast cell activation involved in immune response (GO:0033006)3.66824300
52positive regulation of mast cell activation (GO:0033005)3.56634683
53type I interferon signaling pathway (GO:0060337)3.56421248
54cellular response to type I interferon (GO:0071357)3.56421248
55response to type I interferon (GO:0034340)3.52854667
56regulation of leukocyte degranulation (GO:0043300)3.48684291
57cellular response to interleukin-15 (GO:0071350)3.48571805
58regulation of mast cell activation (GO:0033003)3.48483695
59negative regulation of T cell mediated immunity (GO:0002710)3.48461103
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.43903781
61myeloid leukocyte mediated immunity (GO:0002444)3.42069632
62germinal center formation (GO:0002467)3.41309388
63response to muramyl dipeptide (GO:0032495)3.39352322
64B cell mediated immunity (GO:0019724)3.38668552
65lipopolysaccharide-mediated signaling pathway (GO:0031663)3.33695220
66leukocyte degranulation (GO:0043299)3.31621431
67regulation of T-helper 2 cell differentiation (GO:0045628)3.27773777
68defense response to protozoan (GO:0042832)3.24641969
69interferon-gamma-mediated signaling pathway (GO:0060333)3.24384998
70regulation of gamma-delta T cell differentiation (GO:0045586)3.22586356
71B cell receptor signaling pathway (GO:0050853)3.19167627
72positive regulation of mast cell activation involved in immune response (GO:0033008)3.18629113
73positive regulation of mast cell degranulation (GO:0043306)3.18629113
74neutrophil chemotaxis (GO:0030593)3.14983753
75regulation of tolerance induction (GO:0002643)3.13298960
76regulation of dendritic cell antigen processing and presentation (GO:0002604)3.12898560
77negative regulation of interleukin-6 production (GO:0032715)3.11482076
78negative regulation of phagocytosis (GO:0050765)3.11263414
79antigen processing and presentation via MHC class Ib (GO:0002475)3.11173315
80regulation of regulated secretory pathway (GO:1903305)3.09307487
81regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.08675175
82negative regulation of T-helper cell differentiation (GO:0045623)3.07579562
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.07579562
84negative regulation of cytokine production involved in immune response (GO:0002719)3.06986305
85neutrophil migration (GO:1990266)3.06933477
86regulation of T cell tolerance induction (GO:0002664)3.06859267
87positive regulation of interferon-alpha production (GO:0032727)3.06812603
88regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.02874485
89negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.01995583
90myeloid leukocyte activation (GO:0002274)3.01669552
91regulation of B cell differentiation (GO:0045577)2.99229884
92positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98772235
93dendritic cell migration (GO:0036336)2.97108049
94positive regulation of cellular amide metabolic process (GO:0034250)2.96921572
95dendritic cell chemotaxis (GO:0002407)2.94426039
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94216298
97negative regulation of erythrocyte differentiation (GO:0045647)2.93192355
98negative regulation of innate immune response (GO:0045824)2.92830909
99regulation of interferon-alpha production (GO:0032647)2.90213920
100positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.89760617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.49603540
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.92038073
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.52635710
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.78789579
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.49598728
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.37042822
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.35082711
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.05065175
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.94257133
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91436049
11* SPI1_23547873_ChIP-Seq_NB4_Human2.90862774
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.85174036
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81080724
14VDR_21846776_ChIP-Seq_THP-1_Human2.77517770
15VDR_24763502_ChIP-Seq_THP-1_Human2.75913124
16SPI1_23127762_ChIP-Seq_K562_Human2.69876487
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.55820950
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.55060995
19RUNX_20019798_ChIP-Seq_JUKART_Human2.52298198
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50574235
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.46180935
22MAF_26560356_Chip-Seq_TH1_Human2.29933483
23SCL_19346495_ChIP-Seq_HPC-7_Human2.28417510
24* RUNX1_22412390_ChIP-Seq_EML_Mouse2.26817617
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22571155
26MYB_26560356_Chip-Seq_TH2_Human2.18910715
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18704691
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.17688683
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09367140
30UTX_26944678_Chip-Seq_JUKART_Human2.06309982
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05717842
32EGR1_19374776_ChIP-ChIP_THP-1_Human2.02424580
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02361474
34MYC_22102868_ChIP-Seq_BL_Human1.97611622
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.90844532
36MYB_26560356_Chip-Seq_TH1_Human1.88359064
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.87983823
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.86161584
39* TCF7_22412390_ChIP-Seq_EML_Mouse1.85040534
40VDR_24787735_ChIP-Seq_THP-1_Human1.84578003
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69576671
42* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67657775
43MAF_26560356_Chip-Seq_TH2_Human1.67651057
44KDM2B_26808549_Chip-Seq_DND41_Human1.61878098
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61047450
46GATA3_27048872_Chip-Seq_THYMUS_Human1.60386258
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.58816971
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.54276891
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53123662
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50898059
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50540186
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49559665
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48459697
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48267576
55* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47787231
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47498081
57* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45683154
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43434592
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39102979
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39049154
61PU_27001747_Chip-Seq_BMDM_Mouse1.35703172
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35382802
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35141050
64SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32934949
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32053064
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31641820
67GATA1_22025678_ChIP-Seq_K562_Human1.30847594
68GATA3_26560356_Chip-Seq_TH2_Human1.30642385
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.28446834
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27866162
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26955595
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25987430
73* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23058770
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22157917
75LXR_22292898_ChIP-Seq_THP-1_Human1.21901345
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18380015
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17265621
78GATA1_19941826_ChIP-Seq_K562_Human1.15339518
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14955645
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14669468
81BCL6_27268052_Chip-Seq_Bcells_Human1.12486991
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12376142
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12360066
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08827529
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.08351498
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06941443
87BCOR_27268052_Chip-Seq_Bcells_Human1.05379431
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.05309829
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98338217
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93909566
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93551258
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92596103
93GATA2_19941826_ChIP-Seq_K562_Human0.91607460
94SPI1_20517297_ChIP-Seq_HL60_Human0.91074927
95* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89638291
96NCOR1_26117541_ChIP-Seq_K562_Human0.87877970
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84472021
98CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83402831
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80979738
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72399448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.34111698
2MP0003436_decreased_susceptibility_to4.40759619
3MP0003303_peritoneal_inflammation4.08283911
4MP0001835_abnormal_antigen_presentation3.68102446
5MP0002419_abnormal_innate_immunity3.37832299
6MP0009785_altered_susceptibility_to3.13165821
7MP0005025_abnormal_response_to3.02489832
8MP0005000_abnormal_immune_tolerance2.87796957
9MP0001800_abnormal_humoral_immune2.82010467
10MP0005671_abnormal_response_to2.81617499
11MP0005387_immune_system_phenotype2.81287168
12MP0001790_abnormal_immune_system2.81287168
13MP0000685_abnormal_immune_system2.72788173
14MP0006082_CNS_inflammation2.72616643
15MP0002723_abnormal_immune_serum2.60865246
16MP0002452_abnormal_antigen_presenting2.52757267
17MP0002420_abnormal_adaptive_immunity2.52231781
18MP0001819_abnormal_immune_cell2.50017413
19MP0002148_abnormal_hypersensitivity_rea2.48849094
20MP0003191_abnormal_cellular_cholesterol2.45391762
21MP0003300_gastrointestinal_ulcer2.39772477
22MP0001533_abnormal_skeleton_physiology2.29415449
23MP0005464_abnormal_platelet_physiology2.04694541
24MP0002405_respiratory_system_inflammati2.02114703
25MP0008260_abnormal_autophagy2.02033639
26MP0009278_abnormal_bone_marrow1.91509774
27MP0002132_abnormal_respiratory_system1.85542845
28MP0000716_abnormal_immune_system1.84098168
29MP0002398_abnormal_bone_marrow1.83547202
30MP0001845_abnormal_inflammatory_respons1.83371094
31MP0003172_abnormal_lysosome_physiology1.83234800
32MP0003828_pulmonary_edema1.79340538
33MP0010155_abnormal_intestine_physiology1.77056704
34MP0000465_gastrointestinal_hemorrhage1.72662800
35MP0003763_abnormal_thymus_physiology1.71575707
36MP0009764_decreased_sensitivity_to1.70443800
37MP0002277_abnormal_respiratory_mucosa1.69700236
38MP0004947_skin_inflammation1.63531826
39MP0003075_altered_response_to1.55376055
40MP0003183_abnormal_peptide_metabolism1.55211151
41MP0008469_abnormal_protein_level1.54872511
42MP0005451_abnormal_body_composition1.54088539
43MP0002396_abnormal_hematopoietic_system1.50845735
44MP0000689_abnormal_spleen_morphology1.50407500
45MP0002722_abnormal_immune_system1.49326471
46MP0003866_abnormal_defecation1.48721282
47MP0002429_abnormal_blood_cell1.45181876
48MP0004510_myositis1.44437209
49MP0009333_abnormal_splenocyte_physiolog1.42084335
50MP0004883_abnormal_blood_vessel1.37687792
51MP0005397_hematopoietic_system_phenotyp1.37511604
52MP0001545_abnormal_hematopoietic_system1.37511604
53MP0000858_altered_metastatic_potential1.36131455
54MP0005310_abnormal_salivary_gland1.31507829
55MP0005058_abnormal_lysosome_morphology1.26817010
56MP0002998_abnormal_bone_remodeling1.26232769
57MP0004381_abnormal_hair_follicle1.24824563
58MP0001851_eye_inflammation1.24651094
59MP0000703_abnormal_thymus_morphology1.24540441
60MP0005164_abnormal_response_to1.17002029
61MP0003690_abnormal_glial_cell1.11492737
62MP0000343_altered_response_to1.10338103
63MP0005166_decreased_susceptibility_to1.07881303
64MP0003806_abnormal_nucleotide_metabolis1.04282483
65MP0008004_abnormal_stomach_pH1.00134066
66MP0003448_altered_tumor_morphology0.94921286
67MP0005390_skeleton_phenotype0.91813397
68MP0009763_increased_sensitivity_to0.89178861
69MP0003656_abnormal_erythrocyte_physiolo0.87489269
70MP0001853_heart_inflammation0.85639049
71MP0003045_fibrosis0.85445610
72MP0002166_altered_tumor_susceptibility0.85236303
73MP0001663_abnormal_digestive_system0.80863031
74MP0000604_amyloidosis0.78724197
75MP0009765_abnormal_xenobiotic_induced0.72870859
76MP0000490_abnormal_crypts_of0.72669852
77MP0002138_abnormal_hepatobiliary_system0.68435511
78MP0004808_abnormal_hematopoietic_stem0.67885208
79MP0003795_abnormal_bone_structure0.66948121
80MP0005075_abnormal_melanosome_morpholog0.66805644
81MP0003221_abnormal_cardiomyocyte_apopto0.66185385
82MP0001873_stomach_inflammation0.64708571
83MP0008874_decreased_physiological_sensi0.63289188
84MP0002332_abnormal_exercise_endurance0.62663095
85MP0000249_abnormal_blood_vessel0.61247213
86MP0005319_abnormal_enzyme/_coenzyme0.61118727
87MP0000015_abnormal_ear_pigmentation0.60994818
88MP0003878_abnormal_ear_physiology0.59819243
89MP0005377_hearing/vestibular/ear_phenot0.59819243
90MP0001986_abnormal_taste_sensitivity0.56900099
91MP0005167_abnormal_blood-brain_barrier0.54834515
92MP0002006_tumorigenesis0.53579282
93MP0002933_joint_inflammation0.53542449
94MP0009840_abnormal_foam_cell0.52252925
95MP0000920_abnormal_myelination0.50991441
96MP0004130_abnormal_muscle_cell0.50781557
97MP0002133_abnormal_respiratory_system0.48403197
98MP0005388_respiratory_system_phenotype0.48403197
99MP0005083_abnormal_biliary_tract0.46907035
100MP0000609_abnormal_liver_physiology0.46881858

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.16877041
2Recurrent abscess formation (HP:0002722)6.44747210
3Recurrent bacterial skin infections (HP:0005406)6.25963995
4Myositis (HP:0100614)6.02681822
5Abnormality of macrophages (HP:0004311)5.81084360
6Orchitis (HP:0100796)5.78841741
7Optic neuritis (HP:0100653)5.44093314
8Retrobulbar optic neuritis (HP:0100654)5.44093314
9Recurrent gram-negative bacterial infections (HP:0005420)5.39744789
10Stomatitis (HP:0010280)5.15053508
11Elevated erythrocyte sedimentation rate (HP:0003565)4.61119248
12Obstructive lung disease (HP:0006536)4.44247945
13Chronic obstructive pulmonary disease (HP:0006510)4.44247945
14Hypochromic microcytic anemia (HP:0004840)4.41049171
15Mediastinal lymphadenopathy (HP:0100721)4.37932212
16Gastrointestinal infarctions (HP:0005244)4.18194547
17Recurrent fungal infections (HP:0002841)4.14534272
18Meningitis (HP:0001287)4.04250993
19Keratoconjunctivitis sicca (HP:0001097)4.01218866
20Recurrent skin infections (HP:0001581)4.00686381
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.97435810
22Gingivitis (HP:0000230)3.74885475
23Urticaria (HP:0001025)3.74360623
24Keratoconjunctivitis (HP:0001096)3.71168415
25Encephalitis (HP:0002383)3.66341035
26Increased IgE level (HP:0003212)3.58655692
27Hypochromic anemia (HP:0001931)3.57143775
28Spontaneous hematomas (HP:0007420)3.56187895
29Vasculitis (HP:0002633)3.48855928
30Chronic mucocutaneous candidiasis (HP:0002728)3.42909877
31Recurrent cutaneous fungal infections (HP:0011370)3.42909877
32Episodic fever (HP:0001954)3.23880305
33Cellulitis (HP:0100658)3.22683326
34Prolonged bleeding time (HP:0003010)3.19506913
35Chest pain (HP:0100749)3.17648401
36Hemoptysis (HP:0002105)3.07060545
37Pulmonary infiltrates (HP:0002113)3.05365267
38Peritonitis (HP:0002586)3.02333975
39Anorexia (HP:0002039)2.94603550
40Amyloidosis (HP:0011034)2.89812678
41Gingival bleeding (HP:0000225)2.88831946
42Arterial thrombosis (HP:0004420)2.83294363
43Petechiae (HP:0000967)2.76308584
44Leukocytosis (HP:0001974)2.75380892
45Pulmonary embolism (HP:0002204)2.70370669
46T lymphocytopenia (HP:0005403)2.65223415
47Epistaxis (HP:0000421)2.64709811
48Osteomyelitis (HP:0002754)2.63618183
49Inflammation of the large intestine (HP:0002037)2.60546874
50Abnormality of T cell number (HP:0011839)2.60000751
51Microcytic anemia (HP:0001935)2.58500267
52Increased IgM level (HP:0003496)2.52031791
53Recurrent viral infections (HP:0004429)2.51861594
54Gangrene (HP:0100758)2.51663198
55Gastrointestinal inflammation (HP:0004386)2.50519703
56Sepsis (HP:0100806)2.43693788
57Granulocytopenia (HP:0001913)2.43234361
58Abnormality of the pleura (HP:0002103)2.42361962
59Pustule (HP:0200039)2.38376071
60Abnormality of T cells (HP:0002843)2.37757875
61Abnormality of liposaccharide metabolism (HP:0010968)2.36895256
62Abnormality of glycosphingolipid metabolism (HP:0004343)2.36895256
63Abnormality of glycolipid metabolism (HP:0010969)2.36895256
64Panhypogammaglobulinemia (HP:0003139)2.35993401
65Abnormality of the peritoneum (HP:0002585)2.33056132
66Increased cerebral lipofuscin (HP:0011813)2.31726674
67Loss of speech (HP:0002371)2.27844505
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.22120468
69Hypergammaglobulinemia (HP:0010702)2.21736682
70Premature loss of primary teeth (HP:0006323)2.21114941
71Purpura (HP:0000979)2.20926794
72Hepatosplenomegaly (HP:0001433)2.19402603
73Abnormality of the endocardium (HP:0004306)2.15288474
74Abnormality of T cell physiology (HP:0011840)2.14324104
75Glomerulopathy (HP:0100820)2.13838264
76Abnormality of the heme biosynthetic pathway (HP:0010472)2.12933862
77Lymphopenia (HP:0001888)2.12547903
78Abnormality of the pericardium (HP:0001697)2.11860468
79Increased serum ferritin (HP:0003281)2.08283327
80Skin ulcer (HP:0200042)2.06057763
81Vertigo (HP:0002321)2.05939621
82Acne (HP:0001061)2.05828978
83Keratitis (HP:0000491)2.05182596
84Colitis (HP:0002583)2.03421131
85Abnormality of iron homeostasis (HP:0011031)2.02961343
86Recurrent pneumonia (HP:0006532)2.00761166
87Abnormality of cells of the lymphoid lineage (HP:0012140)2.00106065
88Eosinophilia (HP:0001880)2.00002153
89Disinhibition (HP:0000734)1.98439380
90Polycythemia (HP:0001901)1.96585390
91Polyneuropathy (HP:0001271)1.94957863
92Abnormal platelet volume (HP:0011876)1.93215842
93Slow saccadic eye movements (HP:0000514)1.93205827
94Toxemia of pregnancy (HP:0100603)1.92025904
95Increased neuronal autofluorescent lipopigment (HP:0002074)1.91040263
96Acute hepatic failure (HP:0006554)1.84628029
97Chronic otitis media (HP:0000389)1.83631020
98Segmental peripheral demyelination/remyelination (HP:0003481)1.83566017
99Metaphyseal cupping (HP:0003021)1.83454773
100Hypermelanotic macule (HP:0001034)1.81524422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.20210913
2IRAK43.54253048
3MAP4K13.35071369
4MAP2K33.28622170
5BLK3.15484346
6ERN12.85185076
7CSK2.84716576
8TYK22.82159300
9FES2.61187491
10TNK22.40529356
11GRK62.35757063
12EPHB12.20462604
13TAOK12.09820305
14ZAP702.08376712
15MAP3K31.94808096
16FGR1.90136495
17MAP3K111.81141524
18PRPF4B1.81002188
19HCK1.78848364
20JAK31.76855657
21MAP3K141.76572865
22TXK1.76344672
23BTK1.74023380
24SYK1.59884078
25IKBKE1.53582994
26TBK11.47052542
27JAK21.45723936
28LYN1.41932640
29SIK31.37309119
30MAP3K11.33738376
31YES11.29269470
32KSR21.27753442
33JAK11.22058552
34MATK1.20738931
35CSF1R1.17293280
36TAOK31.16361799
37KIT1.15934757
38MAP3K131.12150304
39TAOK21.10752326
40LCK1.09989366
41IRAK11.09503535
42MAP3K61.04810856
43MARK31.01362950
44BMPR21.00486323
45IRAK20.98722879
46MARK20.97088858
47CDK190.92676746
48SIK20.91837869
49IKBKB0.91394287
50PTK60.90042771
51TESK20.89991144
52ITK0.87829841
53PRKD20.87364151
54PDK10.82387960
55MAP2K40.78313106
56TEC0.78186421
57STK100.76671278
58PDPK10.76032140
59TGFBR20.73792858
60MAP3K20.72881230
61MAP3K50.70401509
62LRRK20.68170729
63FYN0.67510654
64IRAK30.66827895
65SMG10.65843986
66TRIB30.65173838
67EPHA30.63941165
68DAPK20.62190914
69PIK3CG0.59179977
70PTK2B0.58916890
71MAP2K60.58188885
72STK110.57526366
73CDC42BPA0.57478206
74DYRK1B0.55109044
75MAPK120.54706142
76MAP3K70.53384183
77MAPK70.47125473
78FGFR30.46985216
79GRK70.46263075
80RPS6KC10.45444368
81RPS6KL10.45444368
82PRKCQ0.44461203
83SGK30.44011926
84SIK10.43891351
85HIPK20.43847477
86STK380.42906735
87RET0.42367115
88RAF10.42108507
89PRKG20.40498199
90PIM10.40460691
91FGFR40.40458325
92MAPKAPK20.40129835
93KSR10.37863331
94RPS6KA60.37770626
95PRKCZ0.36651379
96ALK0.35848558
97PRKCD0.33731067
98DYRK30.25101536
99MAP3K80.24508393
100NLK0.24038756

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.22787644
2Osteoclast differentiation_Homo sapiens_hsa043803.17122394
3Staphylococcus aureus infection_Homo sapiens_hsa051503.07386024
4Graft-versus-host disease_Homo sapiens_hsa053322.36848166
5Allograft rejection_Homo sapiens_hsa053302.34208093
6Tuberculosis_Homo sapiens_hsa051522.33806776
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19673687
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19369791
9B cell receptor signaling pathway_Homo sapiens_hsa046622.18048380
10Autoimmune thyroid disease_Homo sapiens_hsa053202.16404570
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.14238029
12Malaria_Homo sapiens_hsa051442.11998023
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.06628933
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92612238
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91417463
16Measles_Homo sapiens_hsa051621.78944047
17Legionellosis_Homo sapiens_hsa051341.77078443
18Type I diabetes mellitus_Homo sapiens_hsa049401.76370122
19Primary immunodeficiency_Homo sapiens_hsa053401.73036353
20Chemokine signaling pathway_Homo sapiens_hsa040621.68672046
21Hematopoietic cell lineage_Homo sapiens_hsa046401.66428032
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64693305
23Acute myeloid leukemia_Homo sapiens_hsa052211.63410487
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.60798819
25Influenza A_Homo sapiens_hsa051641.60225508
26Antigen processing and presentation_Homo sapiens_hsa046121.59645436
27Toxoplasmosis_Homo sapiens_hsa051451.58368591
28Phagosome_Homo sapiens_hsa041451.57514576
29Viral myocarditis_Homo sapiens_hsa054161.52093770
30African trypanosomiasis_Homo sapiens_hsa051431.51083956
31Asthma_Homo sapiens_hsa053101.45331118
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44301977
33T cell receptor signaling pathway_Homo sapiens_hsa046601.40353193
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37211698
35Herpes simplex infection_Homo sapiens_hsa051681.37029080
36TNF signaling pathway_Homo sapiens_hsa046681.33347851
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.33346152
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.31280577
39Other glycan degradation_Homo sapiens_hsa005111.26716344
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.23963524
41Pertussis_Homo sapiens_hsa051331.18997883
42Rheumatoid arthritis_Homo sapiens_hsa053231.18931346
43Salmonella infection_Homo sapiens_hsa051321.17894957
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17324709
45Hepatitis B_Homo sapiens_hsa051611.12623276
46Hepatitis C_Homo sapiens_hsa051601.10830568
47Shigellosis_Homo sapiens_hsa051311.07868796
48Platelet activation_Homo sapiens_hsa046111.06643418
49Non-small cell lung cancer_Homo sapiens_hsa052231.05847136
50Lysosome_Homo sapiens_hsa041420.93383431
51Pancreatic cancer_Homo sapiens_hsa052120.92702461
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92639586
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91945922
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90601607
55Apoptosis_Homo sapiens_hsa042100.88190069
56VEGF signaling pathway_Homo sapiens_hsa043700.87872678
57Chronic myeloid leukemia_Homo sapiens_hsa052200.84357203
58Endocytosis_Homo sapiens_hsa041440.78316002
59Prolactin signaling pathway_Homo sapiens_hsa049170.77345757
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.74356598
61Renal cell carcinoma_Homo sapiens_hsa052110.73508439
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.73290110
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72565250
64Amoebiasis_Homo sapiens_hsa051460.70628258
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69952332
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68338047
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68246565
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.67937449
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67924821
70Epstein-Barr virus infection_Homo sapiens_hsa051690.66461416
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64543821
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63660439
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.61143731
74Notch signaling pathway_Homo sapiens_hsa043300.59832208
75FoxO signaling pathway_Homo sapiens_hsa040680.58899382
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.57807937
77Viral carcinogenesis_Homo sapiens_hsa052030.56395832
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55711151
79GnRH signaling pathway_Homo sapiens_hsa049120.52795388
80HIF-1 signaling pathway_Homo sapiens_hsa040660.50827358
81Endometrial cancer_Homo sapiens_hsa052130.50205538
82Choline metabolism in cancer_Homo sapiens_hsa052310.50204606
83Dorso-ventral axis formation_Homo sapiens_hsa043200.48976179
84Regulation of autophagy_Homo sapiens_hsa041400.47604800
85Type II diabetes mellitus_Homo sapiens_hsa049300.47227918
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44417356
87HTLV-I infection_Homo sapiens_hsa051660.43691041
88Collecting duct acid secretion_Homo sapiens_hsa049660.43248098
89Insulin resistance_Homo sapiens_hsa049310.42525566
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42149787
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41947125
92MAPK signaling pathway_Homo sapiens_hsa040100.41499899
93Rap1 signaling pathway_Homo sapiens_hsa040150.40635137
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39836223
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.39270255
96Colorectal cancer_Homo sapiens_hsa052100.38970902
97mTOR signaling pathway_Homo sapiens_hsa041500.38902446
98Inositol phosphate metabolism_Homo sapiens_hsa005620.35754650
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35440987
100ErbB signaling pathway_Homo sapiens_hsa040120.30440784

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