SIGLEC14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.93897952
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.93897952
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.93897952
4modulation by symbiont of host immune response (GO:0052553)5.93897952
5positive regulation by symbiont of host defense response (GO:0052509)5.93897952
6modulation by symbiont of host defense response (GO:0052031)5.93897952
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.93402696
8negative regulation of cell killing (GO:0031342)5.93402696
9positive regulation of gamma-delta T cell activation (GO:0046645)5.70922981
10neutrophil activation involved in immune response (GO:0002283)5.66707426
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.64148478
12response to peptidoglycan (GO:0032494)5.56299620
13detection of other organism (GO:0098543)5.36200912
14macrophage activation involved in immune response (GO:0002281)5.16925659
15detection of bacterium (GO:0016045)5.11049195
16negative regulation of interleukin-12 production (GO:0032695)4.99839752
17antigen processing and presentation of endogenous antigen (GO:0019883)4.90708342
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.84909962
19cellular extravasation (GO:0045123)4.78556500
20leukocyte aggregation (GO:0070486)4.55682498
21leukocyte migration involved in inflammatory response (GO:0002523)4.54550463
22detection of external biotic stimulus (GO:0098581)4.52173595
23neutrophil activation (GO:0042119)4.49984232
24regulation of B cell receptor signaling pathway (GO:0050855)4.47394585
25detection of molecule of bacterial origin (GO:0032490)4.45149396
26immunoglobulin mediated immune response (GO:0016064)4.38660077
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.38133631
28regulation of interferon-beta biosynthetic process (GO:0045357)4.32304660
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.18451408
30respiratory burst (GO:0045730)4.17611809
31granulocyte activation (GO:0036230)4.15126523
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.14119146
33response to host immune response (GO:0052572)4.14119146
34microglial cell activation (GO:0001774)4.12338277
35regulation of gamma-delta T cell activation (GO:0046643)4.07722775
36negative regulation of lymphocyte mediated immunity (GO:0002707)4.07044134
37detection of biotic stimulus (GO:0009595)4.06353892
38regulation of mast cell degranulation (GO:0043304)3.99716597
39positive regulation of mast cell activation (GO:0033005)3.90171971
40myeloid cell activation involved in immune response (GO:0002275)3.85338752
41macrophage activation (GO:0042116)3.83685472
42neutrophil mediated immunity (GO:0002446)3.82047392
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.82045333
44response to host (GO:0075136)3.74623736
45response to host defenses (GO:0052200)3.74623736
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.74623736
47regulation of mast cell activation involved in immune response (GO:0033006)3.71187522
48negative regulation of T cell mediated immunity (GO:0002710)3.67559433
49regulation of mast cell activation (GO:0033003)3.66501894
50regulation of myeloid leukocyte mediated immunity (GO:0002886)3.62221555
51negative regulation of leukocyte mediated immunity (GO:0002704)3.59351841
52cellular response to type I interferon (GO:0071357)3.55558776
53type I interferon signaling pathway (GO:0060337)3.55558776
54production of molecular mediator involved in inflammatory response (GO:0002532)3.55291879
55response to type I interferon (GO:0034340)3.52796672
56positive regulation of mast cell degranulation (GO:0043306)3.50627108
57positive regulation of mast cell activation involved in immune response (GO:0033008)3.50627108
58response to muramyl dipeptide (GO:0032495)3.48522845
59response to interleukin-15 (GO:0070672)3.45568857
60regulation of leukocyte degranulation (GO:0043300)3.43094910
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.40535281
62B cell mediated immunity (GO:0019724)3.40339865
63germinal center formation (GO:0002467)3.37101055
64interferon-gamma-mediated signaling pathway (GO:0060333)3.36745558
65lipopolysaccharide-mediated signaling pathway (GO:0031663)3.34933577
66regulation of dendritic cell antigen processing and presentation (GO:0002604)3.33363793
67defense response to protozoan (GO:0042832)3.32551612
68regulation of tolerance induction (GO:0002643)3.26052763
69myeloid leukocyte mediated immunity (GO:0002444)3.26048859
70leukocyte degranulation (GO:0043299)3.24921987
71positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.22347755
72regulation of gamma-delta T cell differentiation (GO:0045586)3.19833944
73positive regulation of interferon-alpha production (GO:0032727)3.19692500
74regulation of T cell tolerance induction (GO:0002664)3.18979932
75negative regulation of interleukin-6 production (GO:0032715)3.14610237
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.14073634
77regulation of T-helper 2 cell differentiation (GO:0045628)3.13171843
78negative regulation of cytokine production involved in immune response (GO:0002719)3.12134168
79cellular response to interleukin-15 (GO:0071350)3.10631204
80regulation of interferon-alpha production (GO:0032647)3.10525983
81positive regulation of B cell differentiation (GO:0045579)3.05425128
82neutrophil chemotaxis (GO:0030593)3.04501692
83positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.04416361
84B cell receptor signaling pathway (GO:0050853)3.04090967
85antigen processing and presentation via MHC class Ib (GO:0002475)3.02126329
86regulation of B cell differentiation (GO:0045577)3.01442864
87regulation of antigen processing and presentation (GO:0002577)3.00940570
88regulation of regulated secretory pathway (GO:1903305)3.00861401
89positive regulation of cellular amide metabolic process (GO:0034250)3.00627800
90negative regulation of erythrocyte differentiation (GO:0045647)3.00543832
91response to protozoan (GO:0001562)2.99933024
92positive regulation of antigen processing and presentation (GO:0002579)2.99093583
93positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98431590
94myeloid leukocyte activation (GO:0002274)2.97472360
95neutrophil migration (GO:1990266)2.96703434
96negative regulation of innate immune response (GO:0045824)2.96041681
97positive regulation of toll-like receptor signaling pathway (GO:0034123)2.92699436
98dendritic cell migration (GO:0036336)2.88880936
99regulation of T cell mediated cytotoxicity (GO:0001914)2.88405075
100negative regulation of phagocytosis (GO:0050765)2.87735602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.00547501
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.22614581
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.68338118
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.72697492
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.70695551
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.51202632
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39495305
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.05166067
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98397818
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.92740398
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88485208
12SPI1_23547873_ChIP-Seq_NB4_Human2.81144013
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.77228529
14VDR_24763502_ChIP-Seq_THP-1_Human2.71393284
15SPI1_23127762_ChIP-Seq_K562_Human2.65111660
16VDR_21846776_ChIP-Seq_THP-1_Human2.58674110
17RUNX_20019798_ChIP-Seq_JUKART_Human2.54527687
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54024962
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.51964516
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43615826
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25403355
22SCL_19346495_ChIP-Seq_HPC-7_Human2.24790167
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19716698
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19538121
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.19418726
26MAF_26560356_Chip-Seq_TH1_Human2.17666538
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.16702770
28MYB_26560356_Chip-Seq_TH2_Human2.15755260
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.11712694
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.09925649
31VDR_24787735_ChIP-Seq_THP-1_Human2.05637213
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.95548769
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95344590
34UTX_26944678_Chip-Seq_JUKART_Human1.93694894
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89060794
36MYB_26560356_Chip-Seq_TH1_Human1.81243503
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74063145
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.73961017
39MYC_22102868_ChIP-Seq_BL_Human1.70148356
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68220401
41TCF7_22412390_ChIP-Seq_EML_Mouse1.67607017
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.67432393
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67180792
44GATA3_27048872_Chip-Seq_THYMUS_Human1.62115114
45MAF_26560356_Chip-Seq_TH2_Human1.57661857
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.50198190
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50157503
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.48957235
49KDM2B_26808549_Chip-Seq_DND41_Human1.47816341
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43731914
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42943284
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42938859
53GATA3_26560356_Chip-Seq_TH2_Human1.40559365
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40315441
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37614094
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37534598
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35616526
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35051379
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33732794
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33330180
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33222774
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32995493
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32884257
64PU_27001747_Chip-Seq_BMDM_Mouse1.32612138
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31589190
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28437123
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27844080
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27263940
69SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25546133
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24333202
71GATA1_22025678_ChIP-Seq_K562_Human1.23959732
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23656402
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23252950
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18327999
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18121901
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15008201
77GATA1_19941826_ChIP-Seq_K562_Human1.13312939
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13285639
79BCL6_27268052_Chip-Seq_Bcells_Human1.10850240
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09689620
81LXR_22292898_ChIP-Seq_THP-1_Human1.08804818
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.06628224
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04692030
84BCOR_27268052_Chip-Seq_Bcells_Human1.03355716
85GATA2_21666600_ChIP-Seq_HMVEC_Human0.98903587
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95917079
87KDM2B_26808549_Chip-Seq_JURKAT_Human0.95354629
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94961312
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91802197
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90040249
91SPI1_20517297_ChIP-Seq_HL60_Human0.88264552
92GATA2_19941826_ChIP-Seq_K562_Human0.86932707
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84746046
94SMRT_27268052_Chip-Seq_Bcells_Human0.82106876
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79686239
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79352364
97STAT1_20625510_ChIP-Seq_HELA_Human0.74930674
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74006840
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73561711
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.72202353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.16897068
2MP0003436_decreased_susceptibility_to4.26899208
3MP0003303_peritoneal_inflammation4.22359536
4MP0001835_abnormal_antigen_presentation3.80246607
5MP0002419_abnormal_innate_immunity3.35979485
6MP0009785_altered_susceptibility_to3.15013514
7MP0005671_abnormal_response_to3.05951176
8MP0005025_abnormal_response_to3.04810658
9MP0005387_immune_system_phenotype2.93470786
10MP0001790_abnormal_immune_system2.93470786
11MP0006082_CNS_inflammation2.92402344
12MP0005000_abnormal_immune_tolerance2.91219214
13MP0001800_abnormal_humoral_immune2.84190704
14MP0000685_abnormal_immune_system2.78881982
15MP0002148_abnormal_hypersensitivity_rea2.69973212
16MP0002723_abnormal_immune_serum2.62995679
17MP0002452_abnormal_antigen_presenting2.58141048
18MP0002420_abnormal_adaptive_immunity2.51110973
19MP0001819_abnormal_immune_cell2.49061340
20MP0003300_gastrointestinal_ulcer2.34142611
21MP0001533_abnormal_skeleton_physiology2.27329843
22MP0003191_abnormal_cellular_cholesterol2.14514806
23MP0005464_abnormal_platelet_physiology2.01110154
24MP0002405_respiratory_system_inflammati1.99258703
25MP0003172_abnormal_lysosome_physiology1.96742362
26MP0009278_abnormal_bone_marrow1.96501153
27MP0001845_abnormal_inflammatory_respons1.86600023
28MP0000716_abnormal_immune_system1.80687967
29MP0009764_decreased_sensitivity_to1.80658097
30MP0010155_abnormal_intestine_physiology1.75459002
31MP0002398_abnormal_bone_marrow1.75273847
32MP0003828_pulmonary_edema1.71013727
33MP0004947_skin_inflammation1.67014298
34MP0002277_abnormal_respiratory_mucosa1.63949021
35MP0003763_abnormal_thymus_physiology1.62847158
36MP0002132_abnormal_respiratory_system1.62272350
37MP0004510_myositis1.58562955
38MP0008469_abnormal_protein_level1.58285025
39MP0008260_abnormal_autophagy1.56366971
40MP0003075_altered_response_to1.52811400
41MP0000465_gastrointestinal_hemorrhage1.52434337
42MP0000689_abnormal_spleen_morphology1.47494991
43MP0005058_abnormal_lysosome_morphology1.45124474
44MP0002722_abnormal_immune_system1.42416498
45MP0009333_abnormal_splenocyte_physiolog1.41825418
46MP0005310_abnormal_salivary_gland1.40826974
47MP0001545_abnormal_hematopoietic_system1.40139616
48MP0005397_hematopoietic_system_phenotyp1.40139616
49MP0002429_abnormal_blood_cell1.39867737
50MP0003866_abnormal_defecation1.36494501
51MP0003183_abnormal_peptide_metabolism1.36458145
52MP0002998_abnormal_bone_remodeling1.28113645
53MP0004883_abnormal_blood_vessel1.26315839
54MP0005451_abnormal_body_composition1.23974197
55MP0000858_altered_metastatic_potential1.20579689
56MP0000343_altered_response_to1.18026031
57MP0001851_eye_inflammation1.17046940
58MP0003690_abnormal_glial_cell1.14085836
59MP0000703_abnormal_thymus_morphology1.13311369
60MP0008004_abnormal_stomach_pH1.12695593
61MP0005166_decreased_susceptibility_to1.11138577
62MP0005164_abnormal_response_to1.10016597
63MP0002396_abnormal_hematopoietic_system1.08860404
64MP0004381_abnormal_hair_follicle1.07836099
65MP0003806_abnormal_nucleotide_metabolis1.00558276
66MP0001853_heart_inflammation0.99390010
67MP0003448_altered_tumor_morphology0.92958701
68MP0002138_abnormal_hepatobiliary_system0.92298860
69MP0005390_skeleton_phenotype0.91591387
70MP0009763_increased_sensitivity_to0.90540644
71MP0001663_abnormal_digestive_system0.89717798
72MP0000604_amyloidosis0.82981567
73MP0003656_abnormal_erythrocyte_physiolo0.81512275
74MP0005167_abnormal_blood-brain_barrier0.81078620
75MP0001986_abnormal_taste_sensitivity0.79242200
76MP0002166_altered_tumor_susceptibility0.77870031
77MP0003045_fibrosis0.76367677
78MP0009765_abnormal_xenobiotic_induced0.74746982
79MP0000015_abnormal_ear_pigmentation0.72600787
80MP0009840_abnormal_foam_cell0.71741195
81MP0001873_stomach_inflammation0.71515553
82MP0000569_abnormal_digit_pigmentation0.69838425
83MP0002332_abnormal_exercise_endurance0.64881258
84MP0003795_abnormal_bone_structure0.64218827
85MP0005075_abnormal_melanosome_morpholog0.63771021
86MP0002254_reproductive_system_inflammat0.62137153
87MP0000249_abnormal_blood_vessel0.59761936
88MP0004808_abnormal_hematopoietic_stem0.59541552
89MP0000490_abnormal_crypts_of0.59526039
90MP0008874_decreased_physiological_sensi0.59202730
91MP0004130_abnormal_muscle_cell0.58847959
92MP0005319_abnormal_enzyme/_coenzyme0.58118786
93MP0002933_joint_inflammation0.52628060
94MP0000920_abnormal_myelination0.52119853
95MP0002693_abnormal_pancreas_physiology0.51871996
96MP0002006_tumorigenesis0.51304035
97MP0005535_abnormal_body_temperature0.47917021
98MP0003221_abnormal_cardiomyocyte_apopto0.46315120
99MP0005381_digestive/alimentary_phenotyp0.45867935
100MP0002653_abnormal_ependyma_morphology0.45558946

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.65685497
2Recurrent abscess formation (HP:0002722)6.22944824
3Recurrent bacterial skin infections (HP:0005406)6.19781462
4Myositis (HP:0100614)6.16717543
5Orchitis (HP:0100796)6.00556536
6Abnormality of macrophages (HP:0004311)5.94407296
7Optic neuritis (HP:0100653)5.77954491
8Retrobulbar optic neuritis (HP:0100654)5.77954491
9Stomatitis (HP:0010280)5.49857185
10Recurrent gram-negative bacterial infections (HP:0005420)5.18439685
11Elevated erythrocyte sedimentation rate (HP:0003565)4.92070949
12Mediastinal lymphadenopathy (HP:0100721)4.29395196
13Chronic obstructive pulmonary disease (HP:0006510)4.24475139
14Obstructive lung disease (HP:0006536)4.24475139
15Keratoconjunctivitis sicca (HP:0001097)4.16092436
16Recurrent fungal infections (HP:0002841)4.13305252
17Gastrointestinal infarctions (HP:0005244)4.08892370
18Recurrent skin infections (HP:0001581)4.02657516
19Meningitis (HP:0001287)3.97451022
20Keratoconjunctivitis (HP:0001096)3.96547374
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.78642304
22Encephalitis (HP:0002383)3.76893142
23Hypochromic microcytic anemia (HP:0004840)3.71029123
24Vasculitis (HP:0002633)3.63620412
25Recurrent cutaneous fungal infections (HP:0011370)3.61062898
26Chronic mucocutaneous candidiasis (HP:0002728)3.61062898
27Urticaria (HP:0001025)3.56834669
28Spontaneous hematomas (HP:0007420)3.42397480
29Gingivitis (HP:0000230)3.41479805
30Increased IgE level (HP:0003212)3.37892906
31Hemoptysis (HP:0002105)3.31078528
32Pulmonary infiltrates (HP:0002113)3.27113369
33Episodic fever (HP:0001954)3.25557409
34Chest pain (HP:0100749)3.19543937
35Amyloidosis (HP:0011034)3.18059028
36Prolonged bleeding time (HP:0003010)3.15892887
37Hypochromic anemia (HP:0001931)3.14667565
38Arterial thrombosis (HP:0004420)2.99276342
39Anorexia (HP:0002039)2.95366865
40Abnormality of liposaccharide metabolism (HP:0010968)2.88026789
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.88026789
42Abnormality of glycolipid metabolism (HP:0010969)2.88026789
43Leukocytosis (HP:0001974)2.87817971
44Increased cerebral lipofuscin (HP:0011813)2.85077026
45Cellulitis (HP:0100658)2.80233462
46Pulmonary embolism (HP:0002204)2.79816107
47Gingival bleeding (HP:0000225)2.73682019
48Petechiae (HP:0000967)2.71831430
49Gangrene (HP:0100758)2.68761985
50Peritonitis (HP:0002586)2.65810971
51Epistaxis (HP:0000421)2.60136946
52T lymphocytopenia (HP:0005403)2.59806055
53Abnormality of the pleura (HP:0002103)2.56476378
54Recurrent viral infections (HP:0004429)2.54475845
55Abnormality of T cell number (HP:0011839)2.54337676
56Pustule (HP:0200039)2.53185011
57Increased IgM level (HP:0003496)2.51924137
58Inflammation of the large intestine (HP:0002037)2.47351742
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.38308188
60Osteomyelitis (HP:0002754)2.35991268
61Granulocytopenia (HP:0001913)2.35362692
62Gastrointestinal inflammation (HP:0004386)2.35333041
63Panhypogammaglobulinemia (HP:0003139)2.33117405
64Abnormality of T cells (HP:0002843)2.32440081
65Loss of speech (HP:0002371)2.32400745
66Microcytic anemia (HP:0001935)2.31318113
67Increased serum ferritin (HP:0003281)2.29035421
68Purpura (HP:0000979)2.28059046
69Sepsis (HP:0100806)2.26612868
70Vertigo (HP:0002321)2.26436083
71Keratitis (HP:0000491)2.25549398
72Hypergammaglobulinemia (HP:0010702)2.20900535
73Abnormality of the endocardium (HP:0004306)2.19541094
74Polyneuropathy (HP:0001271)2.18147507
75Abnormality of iron homeostasis (HP:0011031)2.16352669
76Abnormality of the pericardium (HP:0001697)2.16342016
77Glomerulopathy (HP:0100820)2.16250318
78Systemic lupus erythematosus (HP:0002725)2.13587080
79Lymphopenia (HP:0001888)2.10632022
80Acne (HP:0001061)2.09363425
81Hepatosplenomegaly (HP:0001433)2.08392738
82Vacuolated lymphocytes (HP:0001922)2.08138034
83Disinhibition (HP:0000734)2.06177368
84Abnormality of the peritoneum (HP:0002585)2.05071838
85Abnormality of T cell physiology (HP:0011840)2.04798486
86Premature loss of primary teeth (HP:0006323)2.03317905
87Eosinophilia (HP:0001880)2.02022362
88Autoimmune thrombocytopenia (HP:0001973)2.01290164
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99156842
90Dysostosis multiplex (HP:0000943)1.98239325
91Abnormality of cells of the lymphoid lineage (HP:0012140)1.95233541
92Chronic otitis media (HP:0000389)1.94033001
93Colitis (HP:0002583)1.93196461
94Skin ulcer (HP:0200042)1.92147985
95Recurrent pneumonia (HP:0006532)1.89431897
96Cheilitis (HP:0100825)1.83779936
97Restrictive lung disease (HP:0002091)1.83555660
98Thrombophlebitis (HP:0004418)1.83550200
99Arthralgia (HP:0002829)1.81030050
100Skin rash (HP:0000988)1.80987646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.06821419
2MAP4K13.46151748
3BLK3.40145810
4IRAK43.31096532
5MAP2K32.94544322
6TYK22.92797533
7CSK2.83126249
8ERN12.63108967
9FES2.53097732
10TNK22.40185092
11ZAP702.13581054
12GRK62.06882636
13TAOK11.97207736
14FGR1.94409177
15TXK1.90340716
16MAP3K141.89176418
17PRPF4B1.85971260
18EPHB11.82413937
19JAK31.80466388
20BTK1.80419526
21MAP3K31.79614341
22HCK1.73488869
23SYK1.71780510
24MAP3K111.64198200
25IKBKE1.64017867
26TBK11.54982426
27LYN1.45713260
28JAK21.43799671
29MAP3K131.33244476
30TAOK31.31606435
31CSF1R1.29966969
32MAP3K11.29681213
33MATK1.28281286
34KIT1.26642257
35JAK11.23752001
36SIK31.19916105
37IRAK11.17314365
38IKBKB1.15577486
39LCK1.14588638
40MARK31.14507336
41YES11.11470746
42KSR21.07350266
43IRAK31.06206239
44BMPR21.05364046
45IRAK21.03835611
46ITK1.02204478
47TAOK20.99760011
48CDK190.94081431
49TEC0.93837826
50PDK10.88046665
51TGFBR20.87585180
52GRK70.85716752
53MARK20.83597312
54SIK20.83158451
55PRKD20.81680378
56STK100.80768036
57DAPK20.78398008
58MAP3K60.77494233
59PDPK10.77057387
60PTK60.74695141
61TESK20.72253808
62MAP2K40.66715373
63PTK2B0.65624240
64MAPK120.64571327
65CDC42BPA0.64022513
66FYN0.63249147
67PIK3CG0.62487861
68MAP3K50.60794788
69MAPK70.60266590
70STK110.57625761
71MAP3K70.56597505
72EPHA30.55170073
73PRKCQ0.53632681
74RPS6KC10.51208149
75RPS6KL10.51208149
76MAP2K60.48828775
77HIPK20.48358187
78SGK30.47867614
79RPS6KA60.46896779
80MAP3K20.45345592
81LRRK20.43702210
82DYRK1B0.43152177
83MOS0.43043950
84PIM10.41098189
85PRKG20.40431421
86SMG10.36344134
87RAF10.35887604
88CAMKK20.35690454
89PRKCZ0.33620408
90TRIB30.32658987
91MAPKAPK20.32618696
92FGFR30.32594273
93KSR10.32039391
94PRKCD0.31103341
95CHUK0.30891536
96ABL10.30413083
97RET0.29853985
98SGK20.29119267
99NLK0.29038915
100RPS6KA20.27726191

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.23089304
2Leishmaniasis_Homo sapiens_hsa051403.17343807
3Osteoclast differentiation_Homo sapiens_hsa043803.12942469
4Graft-versus-host disease_Homo sapiens_hsa053322.59788773
5Allograft rejection_Homo sapiens_hsa053302.57283666
6Autoimmune thyroid disease_Homo sapiens_hsa053202.34785099
7Tuberculosis_Homo sapiens_hsa051522.34332047
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18583522
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.13097058
10B cell receptor signaling pathway_Homo sapiens_hsa046622.08594454
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.07762408
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06635679
13Malaria_Homo sapiens_hsa051442.02082207
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.98869567
15Type I diabetes mellitus_Homo sapiens_hsa049401.97827501
16Asthma_Homo sapiens_hsa053101.79823151
17Primary immunodeficiency_Homo sapiens_hsa053401.78607242
18Hematopoietic cell lineage_Homo sapiens_hsa046401.75797826
19Legionellosis_Homo sapiens_hsa051341.71320081
20Antigen processing and presentation_Homo sapiens_hsa046121.69697877
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.69174992
22Measles_Homo sapiens_hsa051621.69065241
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67792313
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.66941144
25Chemokine signaling pathway_Homo sapiens_hsa040621.65759934
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59683695
27Influenza A_Homo sapiens_hsa051641.59111873
28Toxoplasmosis_Homo sapiens_hsa051451.56247183
29Phagosome_Homo sapiens_hsa041451.56119729
30Viral myocarditis_Homo sapiens_hsa054161.51728863
31Acute myeloid leukemia_Homo sapiens_hsa052211.47080844
32African trypanosomiasis_Homo sapiens_hsa051431.44899116
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43199041
34Rheumatoid arthritis_Homo sapiens_hsa053231.39951347
35Other glycan degradation_Homo sapiens_hsa005111.39809090
36T cell receptor signaling pathway_Homo sapiens_hsa046601.38241411
37Herpes simplex infection_Homo sapiens_hsa051681.35187372
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33494739
39TNF signaling pathway_Homo sapiens_hsa046681.32321092
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.31772756
41Pertussis_Homo sapiens_hsa051331.30152166
42Lysosome_Homo sapiens_hsa041421.10890554
43Salmonella infection_Homo sapiens_hsa051321.10865832
44Hepatitis B_Homo sapiens_hsa051611.04636653
45Platelet activation_Homo sapiens_hsa046111.03170751
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.03119532
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02965770
48Hepatitis C_Homo sapiens_hsa051601.02789498
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02457994
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01961205
51Shigellosis_Homo sapiens_hsa051310.95509420
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87786431
53Non-small cell lung cancer_Homo sapiens_hsa052230.84900292
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.83154961
55VEGF signaling pathway_Homo sapiens_hsa043700.80363747
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80163146
57Apoptosis_Homo sapiens_hsa042100.78229898
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72994813
59Prolactin signaling pathway_Homo sapiens_hsa049170.72535767
60Pancreatic cancer_Homo sapiens_hsa052120.71577173
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.68425342
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.67169089
63Endocytosis_Homo sapiens_hsa041440.65128583
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.64742571
65Amoebiasis_Homo sapiens_hsa051460.63944012
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63912454
67Chronic myeloid leukemia_Homo sapiens_hsa052200.62135245
68Epstein-Barr virus infection_Homo sapiens_hsa051690.61976344
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61522032
70Renal cell carcinoma_Homo sapiens_hsa052110.58977784
71Dorso-ventral axis formation_Homo sapiens_hsa043200.58299136
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58057127
73Notch signaling pathway_Homo sapiens_hsa043300.57035598
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.56555875
75Type II diabetes mellitus_Homo sapiens_hsa049300.55516411
76Regulation of autophagy_Homo sapiens_hsa041400.54252541
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53782764
78FoxO signaling pathway_Homo sapiens_hsa040680.52877745
79GnRH signaling pathway_Homo sapiens_hsa049120.52195072
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48714373
81Collecting duct acid secretion_Homo sapiens_hsa049660.46005836
82Choline metabolism in cancer_Homo sapiens_hsa052310.45639394
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44810247
84HIF-1 signaling pathway_Homo sapiens_hsa040660.44032444
85Viral carcinogenesis_Homo sapiens_hsa052030.43407179
86MAPK signaling pathway_Homo sapiens_hsa040100.41653632
87Insulin resistance_Homo sapiens_hsa049310.41309816
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40786680
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.40161968
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39814628
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39650742
92HTLV-I infection_Homo sapiens_hsa051660.38294817
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35073259
94Rap1 signaling pathway_Homo sapiens_hsa040150.34903428
95Endometrial cancer_Homo sapiens_hsa052130.34495770
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33479373
97mTOR signaling pathway_Homo sapiens_hsa041500.31369855
98Complement and coagulation cascades_Homo sapiens_hsa046100.29878076
99Colorectal cancer_Homo sapiens_hsa052100.25327202
100Inositol phosphate metabolism_Homo sapiens_hsa005620.25134925

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