SIGLEC12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.93497441
2positive regulation of gamma-delta T cell activation (GO:0046645)5.85356118
3positive regulation of B cell differentiation (GO:0045579)5.22500588
4neutrophil activation involved in immune response (GO:0002283)5.09339500
5response to peptidoglycan (GO:0032494)4.93380470
6immunoglobulin mediated immune response (GO:0016064)4.27484278
7regulation of mast cell degranulation (GO:0043304)4.23204243
8regulation of gamma-delta T cell differentiation (GO:0045586)4.15974763
9regulation of gamma-delta T cell activation (GO:0046643)4.10918203
10cellular extravasation (GO:0045123)4.03282503
11regulation of hypersensitivity (GO:0002883)3.92530293
12regulation of myeloid leukocyte mediated immunity (GO:0002886)3.90402633
13regulation of mast cell activation involved in immune response (GO:0033006)3.82568629
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.80335414
15response to muramyl dipeptide (GO:0032495)3.70466838
16definitive hemopoiesis (GO:0060216)3.69935042
17regulation of B cell differentiation (GO:0045577)3.68505540
18regulation of leukocyte degranulation (GO:0043300)3.61244908
19mannose metabolic process (GO:0006013)3.59907945
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.53205912
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.53205912
22modulation by symbiont of host immune response (GO:0052553)3.53205912
23positive regulation by symbiont of host defense response (GO:0052509)3.53205912
24modulation by symbiont of host defense response (GO:0052031)3.53205912
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.53205912
26poly(A)+ mRNA export from nucleus (GO:0016973)3.53143781
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.50830257
28B cell receptor signaling pathway (GO:0050853)3.47013635
29respiratory burst (GO:0045730)3.42353961
30regulation of B cell receptor signaling pathway (GO:0050855)3.36746539
31regulation of vitamin D biosynthetic process (GO:0060556)3.33987221
32B cell mediated immunity (GO:0019724)3.31970630
33pinocytosis (GO:0006907)3.31565203
34germinal center formation (GO:0002467)3.26313403
35positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.26030314
36detection of other organism (GO:0098543)3.24212072
37mucosal-associated lymphoid tissue development (GO:0048537)3.23657823
38Peyers patch development (GO:0048541)3.23657823
39lipopolysaccharide-mediated signaling pathway (GO:0031663)3.23117436
40cellular response to thyroid hormone stimulus (GO:0097067)3.22677886
41regulation of mast cell activation (GO:0033003)3.22493878
42negative regulation of interleukin-12 production (GO:0032695)3.15699362
43megakaryocyte development (GO:0035855)3.15593840
44neutrophil activation (GO:0042119)3.14221995
45leukocyte degranulation (GO:0043299)3.13421527
46regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.10876675
47negative regulation of T cell mediated immunity (GO:0002710)3.06020154
48regulation of vitamin metabolic process (GO:0030656)3.05707583
49regulation of interleukin-2 biosynthetic process (GO:0045076)3.03185890
50positive regulation of mast cell activation involved in immune response (GO:0033008)3.02429226
51positive regulation of mast cell degranulation (GO:0043306)3.02429226
52detection of bacterium (GO:0016045)3.01164312
53macrophage differentiation (GO:0030225)3.00413694
54antigen processing and presentation of endogenous antigen (GO:0019883)2.99743067
55response to thyroid hormone (GO:0097066)2.99104658
56positive regulation of granulocyte differentiation (GO:0030854)2.96228467
57granulocyte activation (GO:0036230)2.94256639
58positive regulation of mast cell activation (GO:0033005)2.92157154
59actin nucleation (GO:0045010)2.91778357
60negative regulation of granulocyte differentiation (GO:0030853)2.90557222
61myeloid cell activation involved in immune response (GO:0002275)2.90303838
62positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.90122592
63positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.89828992
64glycosphingolipid catabolic process (GO:0046479)2.89189194
65regulation of regulated secretory pathway (GO:1903305)2.87439813
66T cell migration (GO:0072678)2.87275915
67negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86922651
68negative regulation of cell killing (GO:0031342)2.86922651
69antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85895645
70positive thymic T cell selection (GO:0045059)2.83494778
71negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.82337554
72regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.81811342
73antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77792560
74leukocyte aggregation (GO:0070486)2.76040290
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75738935
76negative thymic T cell selection (GO:0045060)2.73770354
77cellular response to exogenous dsRNA (GO:0071360)2.71890405
78tolerance induction (GO:0002507)2.70698725
79response to protozoan (GO:0001562)2.69606535
80interferon-gamma-mediated signaling pathway (GO:0060333)2.67205731
81negative regulation of myeloid cell apoptotic process (GO:0033033)2.66469378
82positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.65152880
83regulation of erythrocyte differentiation (GO:0045646)2.64938103
84negative regulation of interleukin-6 production (GO:0032715)2.64650029
85angiotensin maturation (GO:0002003)2.64509475
86regulation of granulocyte differentiation (GO:0030852)2.61967823
87glycolipid catabolic process (GO:0019377)2.61902128
88regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.60134814
89positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.59478170
90regulation of tolerance induction (GO:0002643)2.58655935
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58124968
92positive regulation of antigen processing and presentation (GO:0002579)2.57546076
93regulation of antigen processing and presentation (GO:0002577)2.56880854
94positive regulation of tumor necrosis factor production (GO:0032760)2.54714938
95cell wall macromolecule catabolic process (GO:0016998)2.54217672
96hyaluronan catabolic process (GO:0030214)2.53891760
97macrophage activation involved in immune response (GO:0002281)2.52656999
98negative T cell selection (GO:0043383)2.51570084
99detection of external biotic stimulus (GO:0098581)2.51538223
100mature B cell differentiation involved in immune response (GO:0002313)2.51383200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.83398828
2VDR_21846776_ChIP-Seq_THP-1_Human3.94506213
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.86327144
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.32306835
5SCL_19346495_ChIP-Seq_HPC-7_Human3.31148423
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31138369
7* VDR_24763502_ChIP-Seq_THP-1_Human3.27509257
8MYC_22102868_ChIP-Seq_BL_Human2.97227693
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.85314462
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.82311505
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.74767190
12* SPI1_23547873_ChIP-Seq_NB4_Human2.69275286
13E2F7_22180533_ChIP-Seq_HELA_Human2.65455857
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60548692
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52733055
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.40037230
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38858498
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.35197413
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32165320
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26479566
21MYB_26560356_Chip-Seq_TH2_Human2.19303085
22SPI1_23127762_ChIP-Seq_K562_Human2.19270272
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16624320
24MAF_26560356_Chip-Seq_TH1_Human2.15193667
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.10673551
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.09651232
27GATA1_22025678_ChIP-Seq_K562_Human2.07608107
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02986123
29UTX_26944678_Chip-Seq_JUKART_Human2.01711848
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94676666
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89138677
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86519778
33TCF7_22412390_ChIP-Seq_EML_Mouse1.85569442
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82900367
35MYB_26560356_Chip-Seq_TH1_Human1.80836740
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73650713
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73106612
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71725615
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69017777
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69004724
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68360245
42GATA1_22383799_ChIP-Seq_G1ME_Mouse1.68327651
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66747395
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.66094937
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58275243
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57394742
47MAF_26560356_Chip-Seq_TH2_Human1.56059376
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55989271
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55604073
50LXR_22292898_ChIP-Seq_THP-1_Human1.55400359
51* GATA1_19941826_ChIP-Seq_K562_Human1.54551891
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54121022
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.53753760
54RUNX_20019798_ChIP-Seq_JUKART_Human1.52391829
55* NCOR1_26117541_ChIP-Seq_K562_Human1.52318902
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51313615
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47959833
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.46495645
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46359920
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.43286625
61KDM2B_26808549_Chip-Seq_DND41_Human1.41441701
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39388297
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38984380
64CIITA_25753668_ChIP-Seq_RAJI_Human1.38075569
65* VDR_24787735_ChIP-Seq_THP-1_Human1.37783782
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35269623
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35241708
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30810382
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29210204
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29121349
71* GATA2_19941826_ChIP-Seq_K562_Human1.28825867
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27206452
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25468036
74GATA3_27048872_Chip-Seq_THYMUS_Human1.17752902
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13892688
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13341149
77* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13135861
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.12709995
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12166479
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10852661
81TFEB_21752829_ChIP-Seq_HELA_Human1.08861958
82BCOR_27268052_Chip-Seq_Bcells_Human1.06558678
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02190249
84* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00264666
85RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00236718
86CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99300377
87PU_27001747_Chip-Seq_BMDM_Mouse0.98121886
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98034957
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97799826
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97430993
91BCL6_27268052_Chip-Seq_Bcells_Human0.97212950
92ETS1_22383799_ChIP-Seq_G1ME_Mouse0.96527513
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96001668
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95935719
95CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95907021
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95048348
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94955489
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92504535
99SPI1_20517297_ChIP-Seq_HL60_Human0.91285528
100SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88649936

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.70666922
2MP0003436_decreased_susceptibility_to3.55536131
3MP0001835_abnormal_antigen_presentation3.38359901
4MP0005464_abnormal_platelet_physiology3.10208675
5MP0002419_abnormal_innate_immunity2.93652311
6MP0003300_gastrointestinal_ulcer2.86009477
7MP0003724_increased_susceptibility_to2.80015052
8MP0005025_abnormal_response_to2.73202470
9MP0005058_abnormal_lysosome_morphology2.70094207
10MP0005000_abnormal_immune_tolerance2.66107856
11MP0002148_abnormal_hypersensitivity_rea2.58220480
12MP0005671_abnormal_response_to2.53047575
13MP0002396_abnormal_hematopoietic_system2.37351162
14MP0001790_abnormal_immune_system2.31318265
15MP0005387_immune_system_phenotype2.31318265
16MP0001800_abnormal_humoral_immune2.30833845
17MP0003172_abnormal_lysosome_physiology2.26730949
18MP0002420_abnormal_adaptive_immunity2.25674912
19MP0002723_abnormal_immune_serum2.24333981
20MP0000465_gastrointestinal_hemorrhage2.24172430
21MP0001819_abnormal_immune_cell2.23595126
22MP0009785_altered_susceptibility_to2.22639550
23MP0002452_abnormal_antigen_presenting2.21410970
24MP0006082_CNS_inflammation2.17968391
25MP0009278_abnormal_bone_marrow2.12302195
26MP0001545_abnormal_hematopoietic_system2.08654532
27MP0005397_hematopoietic_system_phenotyp2.08654532
28MP0009840_abnormal_foam_cell2.05708585
29MP0000685_abnormal_immune_system1.96937113
30MP0002398_abnormal_bone_marrow1.95955403
31MP0003763_abnormal_thymus_physiology1.93487616
32MP0009333_abnormal_splenocyte_physiolog1.91729782
33MP0010155_abnormal_intestine_physiology1.91639659
34MP0000716_abnormal_immune_system1.83573773
35MP0001845_abnormal_inflammatory_respons1.78837272
36MP0003191_abnormal_cellular_cholesterol1.74334511
37MP0002405_respiratory_system_inflammati1.71267609
38MP0000689_abnormal_spleen_morphology1.71005408
39MP0002722_abnormal_immune_system1.70230701
40MP0004947_skin_inflammation1.65631804
41MP0004808_abnormal_hematopoietic_stem1.64593956
42MP0001853_heart_inflammation1.64076201
43MP0005360_urolithiasis1.62702602
44MP0002429_abnormal_blood_cell1.62452695
45MP0003656_abnormal_erythrocyte_physiolo1.61400606
46MP0001533_abnormal_skeleton_physiology1.56905946
47MP0009764_decreased_sensitivity_to1.46936646
48MP0008469_abnormal_protein_level1.45143630
49MP0009379_abnormal_foot_pigmentation1.44277786
50MP0003828_pulmonary_edema1.43426577
51MP0002009_preneoplasia1.41348093
52MP0003866_abnormal_defecation1.39861543
53MP0000343_altered_response_to1.38486331
54MP0000703_abnormal_thymus_morphology1.37640404
55MP0005451_abnormal_body_composition1.35345438
56MP0002166_altered_tumor_susceptibility1.27294420
57MP0003183_abnormal_peptide_metabolism1.26392185
58MP0003806_abnormal_nucleotide_metabolis1.25912373
59MP0002877_abnormal_melanocyte_morpholog1.24593155
60MP0000490_abnormal_crypts_of1.18326728
61MP0000604_amyloidosis1.18000184
62MP0002132_abnormal_respiratory_system1.14902724
63MP0002998_abnormal_bone_remodeling1.13250451
64MP0000858_altered_metastatic_potential1.09330871
65MP0003075_altered_response_to1.09275542
66MP0003448_altered_tumor_morphology1.08901362
67MP0009763_increased_sensitivity_to1.05656270
68MP0001851_eye_inflammation1.02646358
69MP0005310_abnormal_salivary_gland0.98623011
70MP0002006_tumorigenesis0.95077684
71MP0005166_decreased_susceptibility_to0.94740369
72MP0009765_abnormal_xenobiotic_induced0.87474477
73MP0004782_abnormal_surfactant_physiolog0.86646299
74MP0008004_abnormal_stomach_pH0.85662864
75MP0001663_abnormal_digestive_system0.85315871
76MP0004264_abnormal_extraembryonic_tissu0.83924598
77MP0001873_stomach_inflammation0.81769191
78MP0005076_abnormal_cell_differentiation0.78953916
79MP0000249_abnormal_blood_vessel0.77760032
80MP0000609_abnormal_liver_physiology0.77335492
81MP0005167_abnormal_blood-brain_barrier0.76794223
82MP0010307_abnormal_tumor_latency0.73878850
83MP0002139_abnormal_hepatobiliary_system0.73226100
84MP0002138_abnormal_hepatobiliary_system0.73034072
85MP0002019_abnormal_tumor_incidence0.73022870
86MP0000015_abnormal_ear_pigmentation0.72994424
87MP0008260_abnormal_autophagy0.72776317
88MP0009115_abnormal_fat_cell0.68713038
89MP0004147_increased_porphyrin_level0.68135052
90MP0005535_abnormal_body_temperature0.67225236
91MP0005174_abnormal_tail_pigmentation0.65979656
92MP0003795_abnormal_bone_structure0.65367151
93MP0005584_abnormal_enzyme/coenzyme_acti0.64323772
94MP0005164_abnormal_response_to0.63698140
95MP0005075_abnormal_melanosome_morpholog0.62259574
96MP0005319_abnormal_enzyme/_coenzyme0.61685910
97MP0000681_abnormal_thyroid_gland0.61279754
98MP0005365_abnormal_bile_salt0.60409772
99MP0005390_skeleton_phenotype0.59249272
100MP0009931_abnormal_skin_appearance0.57379215

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.21130247
2Recurrent bacterial skin infections (HP:0005406)4.93278323
3Abnormality of macrophages (HP:0004311)4.43202126
4Elevated erythrocyte sedimentation rate (HP:0003565)4.41483835
5Eczematoid dermatitis (HP:0000976)4.32655389
6Systemic lupus erythematosus (HP:0002725)4.21141669
7Stomatitis (HP:0010280)4.08140363
8Petechiae (HP:0000967)3.90311727
9Myositis (HP:0100614)3.87476328
10Obstructive lung disease (HP:0006536)3.72753661
11Chronic obstructive pulmonary disease (HP:0006510)3.72753661
12Recurrent viral infections (HP:0004429)3.66886464
13Prolonged bleeding time (HP:0003010)3.63900248
14Abnormality of liposaccharide metabolism (HP:0010968)3.49333265
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.49333265
16Abnormality of glycolipid metabolism (HP:0010969)3.49333265
17Recurrent fungal infections (HP:0002841)3.47885695
18Thrombocytosis (HP:0001894)3.47803823
19Recurrent skin infections (HP:0001581)3.36072726
20Amyloidosis (HP:0011034)3.33975708
21Mediastinal lymphadenopathy (HP:0100721)3.25946710
22Meningitis (HP:0001287)3.25139399
23Recurrent cutaneous fungal infections (HP:0011370)3.19113875
24Chronic mucocutaneous candidiasis (HP:0002728)3.19113875
25Granulocytopenia (HP:0001913)3.17195101
26Abnormality of B cell number (HP:0010975)3.03684137
27Cellulitis (HP:0100658)3.01302129
28Vacuolated lymphocytes (HP:0001922)3.00286974
29Abnormal platelet function (HP:0011869)2.98797691
30Impaired platelet aggregation (HP:0003540)2.98797691
31Dysostosis multiplex (HP:0000943)2.94801993
32B lymphocytopenia (HP:0010976)2.94360054
33Panhypogammaglobulinemia (HP:0003139)2.91287605
34Acute lymphatic leukemia (HP:0006721)2.90852397
35Spontaneous hematomas (HP:0007420)2.89619162
36Pustule (HP:0200039)2.88560163
37Encephalitis (HP:0002383)2.88252086
38Increased cerebral lipofuscin (HP:0011813)2.86000992
39Agammaglobulinemia (HP:0004432)2.84470456
40Epistaxis (HP:0000421)2.83886300
41Recurrent gram-negative bacterial infections (HP:0005420)2.82497147
42Abnormality of the prostate (HP:0008775)2.82171258
43Gingivitis (HP:0000230)2.78032672
44Purpura (HP:0000979)2.76478109
45Vasculitis (HP:0002633)2.76072180
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.73973517
47Hepatosplenomegaly (HP:0001433)2.72821811
48Increased IgE level (HP:0003212)2.71358232
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.66989562
50Orchitis (HP:0100796)2.66863652
51Urticaria (HP:0001025)2.62604886
52Thoracic kyphosis (HP:0002942)2.60961887
53Acute myeloid leukemia (HP:0004808)2.56549422
54Osteomyelitis (HP:0002754)2.55259035
55Leukocytosis (HP:0001974)2.53901659
56Autoimmune thrombocytopenia (HP:0001973)2.53041524
57Increased serum ferritin (HP:0003281)2.51666570
58Colitis (HP:0002583)2.50225540
59Inflammation of the large intestine (HP:0002037)2.42606518
60Abnormality of complement system (HP:0005339)2.42007800
61Hemoptysis (HP:0002105)2.40078556
62Gastrointestinal inflammation (HP:0004386)2.39950199
63Episodic fever (HP:0001954)2.36854603
64Glomerulonephritis (HP:0000099)2.34766672
65Chest pain (HP:0100749)2.31833882
66Interstitial pulmonary disease (HP:0006530)2.30511967
67Abnormality of the lumbar spine (HP:0100712)2.29204448
68Abnormality of T cell physiology (HP:0011840)2.28906054
69Hypergammaglobulinemia (HP:0010702)2.27050874
70Skin rash (HP:0000988)2.25996733
71Optic neuritis (HP:0100653)2.24126342
72Retrobulbar optic neuritis (HP:0100654)2.24126342
73Premature loss of primary teeth (HP:0006323)2.21467153
74Abnormality of iron homeostasis (HP:0011031)2.21064339
75Gingival bleeding (HP:0000225)2.17001480
76Abnormality of T cells (HP:0002843)2.16413766
77Loss of speech (HP:0002371)2.16072933
78Gastrointestinal infarctions (HP:0005244)2.15194768
79Arterial thrombosis (HP:0004420)2.11738095
80Autoimmune hemolytic anemia (HP:0001890)2.11058171
81Chronic otitis media (HP:0000389)2.10788246
82Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.01824337
83IgM deficiency (HP:0002850)2.00527483
84Complement deficiency (HP:0004431)1.99191287
85Aplastic anemia (HP:0001915)1.99169939
86Pulmonary infiltrates (HP:0002113)1.97690646
87Abnormality of the thoracic spine (HP:0100711)1.95688640
88Skin ulcer (HP:0200042)1.94726765
89Joint swelling (HP:0001386)1.92735899
90Malnutrition (HP:0004395)1.91782426
91Abnormality of transition element cation homeostasis (HP:0011030)1.89395972
92Keratoconjunctivitis sicca (HP:0001097)1.89259961
93Abnormality of the vasculature of the conjunctiva (HP:0008054)1.87419664
94Pulmonary embolism (HP:0002204)1.87364285
95Abnormality of polysaccharide metabolism (HP:0011012)1.85319959
96Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85319959
97Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85319959
98Eosinophilia (HP:0001880)1.84033754
99Pulmonary fibrosis (HP:0002206)1.83205875
100Mucopolysacchariduria (HP:0008155)1.82597980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.01392570
2FES3.09348294
3ERN13.07709703
4MAP4K12.81388144
5PRPF4B2.79189955
6MAP3K142.74487723
7MATK2.67466618
8KIT2.51474755
9BLK2.44127419
10BTK2.39540254
11NME22.27661709
12MAP2K32.11183148
13TYK22.07261277
14TEC2.00993498
15TBK12.00708300
16IRAK31.97595976
17ZAP701.89561691
18GRK61.88507817
19SYK1.84066155
20MAP3K61.76873554
21MAP3K131.61256071
22LYN1.60133407
23TRIB31.60071612
24CSF1R1.54569816
25TAOK31.53514672
26RPS6KA41.50417770
27TXK1.49932788
28CSK1.46577327
29EEF2K1.46295254
30BMPR21.45003263
31IRAK41.44310344
32TNK21.40448983
33JAK31.38376731
34CLK11.36222337
35CDK61.34818960
36HCK1.33820659
37ITK1.28560010
38MAP3K11.21384009
39JAK11.19605920
40JAK21.18840439
41IKBKB1.12558731
42LCK1.12089077
43IKBKE1.11776321
44LRRK21.10035151
45PKN21.01073709
46TAOK20.92562344
47FGR0.87297047
48PDPK10.83806292
49SMG10.83464672
50HIPK20.82852034
51ICK0.80953278
52PIM10.80599432
53MAP2K20.79963374
54TESK20.77423378
55CDK40.76740653
56PDK10.76458542
57MAP3K110.76161943
58BMX0.71236836
59MAPK120.70444431
60YES10.68317905
61STK100.68146359
62RPS6KL10.65805239
63RPS6KC10.65805239
64MARK20.65281746
65MAPK110.64441695
66MAP3K80.63854863
67PRKCQ0.63405919
68FLT30.59790918
69RET0.56948230
70PIK3CG0.55668550
71SCYL20.55090287
72FGFR30.54947869
73MAPK40.54557053
74MARK30.52524074
75RPS6KA60.50242752
76TGFBR20.47697738
77KSR20.44639474
78MAPK30.44376857
79MAP2K60.43331560
80IRAK20.42737207
81PTK60.42253701
82TRPM70.41418676
83CDK120.40416630
84SIK30.38787844
85TAOK10.37661029
86ALK0.35950482
87IRAK10.35751464
88ABL10.35729765
89FYN0.35437487
90MAPKAPK20.33559428
91CDK190.32357169
92CDK30.32277514
93MAP3K50.31946684
94PRKG20.30452289
95MAP3K70.30396866
96MAP3K30.27067158
97RPS6KA10.26695947
98MAPK70.24190691
99RPS6KB20.23892443
100PAK10.20544662

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.44520677
2Staphylococcus aureus infection_Homo sapiens_hsa051503.20859324
3Leishmaniasis_Homo sapiens_hsa051403.17340024
4Asthma_Homo sapiens_hsa053102.90321427
5Osteoclast differentiation_Homo sapiens_hsa043802.47841445
6Graft-versus-host disease_Homo sapiens_hsa053322.37186542
7Allograft rejection_Homo sapiens_hsa053302.30839298
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26823574
9Hematopoietic cell lineage_Homo sapiens_hsa046402.17750603
10B cell receptor signaling pathway_Homo sapiens_hsa046622.17642351
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.15706028
12Autoimmune thyroid disease_Homo sapiens_hsa053202.06950925
13Acute myeloid leukemia_Homo sapiens_hsa052212.00977998
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.95562633
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93567208
16Tuberculosis_Homo sapiens_hsa051521.93557810
17Antigen processing and presentation_Homo sapiens_hsa046121.91984652
18Type I diabetes mellitus_Homo sapiens_hsa049401.76821325
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74693489
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74174047
21Rheumatoid arthritis_Homo sapiens_hsa053231.73876712
22Pertussis_Homo sapiens_hsa051331.67439228
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.64542255
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63439748
25Influenza A_Homo sapiens_hsa051641.61227624
26Primary immunodeficiency_Homo sapiens_hsa053401.59384579
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52334691
28Legionellosis_Homo sapiens_hsa051341.48133260
29Toxoplasmosis_Homo sapiens_hsa051451.45913907
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44860651
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42526862
32Measles_Homo sapiens_hsa051621.41363220
33Herpes simplex infection_Homo sapiens_hsa051681.35723800
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35114437
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33507934
36Lysosome_Homo sapiens_hsa041421.33247662
37Phagosome_Homo sapiens_hsa041451.32312817
38Platelet activation_Homo sapiens_hsa046111.26034712
39Renin-angiotensin system_Homo sapiens_hsa046141.20651247
40Malaria_Homo sapiens_hsa051441.20452291
41T cell receptor signaling pathway_Homo sapiens_hsa046601.19794758
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.19455662
43Chemokine signaling pathway_Homo sapiens_hsa040621.18393833
44Hepatitis B_Homo sapiens_hsa051611.18303569
45Viral myocarditis_Homo sapiens_hsa054161.16594753
46TNF signaling pathway_Homo sapiens_hsa046681.16448791
47Systemic lupus erythematosus_Homo sapiens_hsa053221.15994183
48Chronic myeloid leukemia_Homo sapiens_hsa052201.08954314
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04180654
50Pancreatic cancer_Homo sapiens_hsa052121.03453974
51Pentose phosphate pathway_Homo sapiens_hsa000300.94996059
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93047925
53Salmonella infection_Homo sapiens_hsa051320.91385892
54Shigellosis_Homo sapiens_hsa051310.86194626
55Apoptosis_Homo sapiens_hsa042100.85500771
56Ribosome_Homo sapiens_hsa030100.85319623
57African trypanosomiasis_Homo sapiens_hsa051430.80543053
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80346950
59Non-small cell lung cancer_Homo sapiens_hsa052230.79855710
60VEGF signaling pathway_Homo sapiens_hsa043700.77326284
61Viral carcinogenesis_Homo sapiens_hsa052030.75257069
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74137005
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71406385
64HTLV-I infection_Homo sapiens_hsa051660.69965688
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67262021
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.67182677
67Galactose metabolism_Homo sapiens_hsa000520.66404639
68Epstein-Barr virus infection_Homo sapiens_hsa051690.65361665
69Prolactin signaling pathway_Homo sapiens_hsa049170.62478064
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.60470125
71Prion diseases_Homo sapiens_hsa050200.59763711
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.58367089
73Amoebiasis_Homo sapiens_hsa051460.57168490
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.57156879
75Hepatitis C_Homo sapiens_hsa051600.57021868
76Fructose and mannose metabolism_Homo sapiens_hsa000510.54716308
77DNA replication_Homo sapiens_hsa030300.54239310
78HIF-1 signaling pathway_Homo sapiens_hsa040660.51319292
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48760700
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.46567762
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.45055023
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43304763
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38051950
84Base excision repair_Homo sapiens_hsa034100.36682904
85Vitamin digestion and absorption_Homo sapiens_hsa049770.36441731
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34895486
87Arachidonic acid metabolism_Homo sapiens_hsa005900.33530484
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32604117
89Complement and coagulation cascades_Homo sapiens_hsa046100.32518818
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32273385
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31675247
92Insulin resistance_Homo sapiens_hsa049310.31212894
93GnRH signaling pathway_Homo sapiens_hsa049120.27282939
94Endocytosis_Homo sapiens_hsa041440.25564801
95Bladder cancer_Homo sapiens_hsa052190.25466360
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.23401862
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.23323867
98Glutathione metabolism_Homo sapiens_hsa004800.22740115
99Renal cell carcinoma_Homo sapiens_hsa052110.22144718
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.21248751

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