SIGLEC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:008.65649088
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:08.65649088
3positive regulation by organism of defense response of other organism involved in symbiotic interact8.65649088
4modulation by symbiont of host immune response (GO:0052553)8.65649088
5positive regulation by symbiont of host defense response (GO:0052509)8.65649088
6modulation by symbiont of host defense response (GO:0052031)8.65649088
7regulation of interferon-beta biosynthetic process (GO:0045357)6.49491911
8response to host immune response (GO:0052572)5.75118590
9response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.75118590
10macrophage activation involved in immune response (GO:0002281)5.66347564
11positive regulation of interferon-alpha production (GO:0032727)5.46932060
12positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.34227696
13regulation of interferon-alpha production (GO:0032647)5.18234149
14response to peptidoglycan (GO:0032494)5.12283824
15response to defenses of other organism involved in symbiotic interaction (GO:0052173)5.11926307
16response to host (GO:0075136)5.11926307
17response to host defenses (GO:0052200)5.11926307
18microglial cell activation (GO:0001774)4.94343771
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.86961843
20immunoglobulin mediated immune response (GO:0016064)4.84658901
21neutrophil activation involved in immune response (GO:0002283)4.47457684
22macrophage activation (GO:0042116)4.14012384
23regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.12143603
24positive regulation of interferon-beta production (GO:0032728)4.01686788
25positive regulation of antigen processing and presentation (GO:0002579)3.98109723
26apoptotic cell clearance (GO:0043277)3.97015345
27regulation of B cell receptor signaling pathway (GO:0050855)3.85571233
28regulation of interleukin-8 biosynthetic process (GO:0045414)3.82478433
29regulation of T-helper 1 cell differentiation (GO:0045625)3.82090055
30detection of molecule of bacterial origin (GO:0032490)3.77623942
31regulation of mast cell degranulation (GO:0043304)3.77525385
32regulation of vitamin D biosynthetic process (GO:0060556)3.75734399
33negative regulation of granulocyte differentiation (GO:0030853)3.74213161
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.72921021
35negative regulation of cell killing (GO:0031342)3.72921021
36respiratory burst (GO:0045730)3.71457747
37pinocytosis (GO:0006907)3.70128771
38regulation of antigen processing and presentation (GO:0002577)3.63017403
39negative regulation of mast cell activation (GO:0033004)3.61471581
40regulation of mast cell activation involved in immune response (GO:0033006)3.61001845
41production of molecular mediator involved in inflammatory response (GO:0002532)3.60520223
42regulation of cytokine secretion involved in immune response (GO:0002739)3.59826163
43negative regulation of cytokine production involved in immune response (GO:0002719)3.58181394
44T-helper 1 type immune response (GO:0042088)3.57603268
45detection of other organism (GO:0098543)3.54783813
46regulation of cholesterol storage (GO:0010885)3.54047957
47positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.52302707
48positive regulation of type 2 immune response (GO:0002830)3.51026369
49positive regulation of toll-like receptor signaling pathway (GO:0034123)3.49787842
50positive regulation of cellular amide metabolic process (GO:0034250)3.48348531
51regulation of mast cell activation (GO:0033003)3.47359659
52myeloid cell activation involved in immune response (GO:0002275)3.46188947
53myeloid dendritic cell differentiation (GO:0043011)3.44091445
54B cell mediated immunity (GO:0019724)3.43610326
55I-kappaB phosphorylation (GO:0007252)3.38485008
56positive regulation of chemokine biosynthetic process (GO:0045080)3.38402727
57response to muramyl dipeptide (GO:0032495)3.37416867
58neutrophil activation (GO:0042119)3.36914491
59positive regulation of mast cell activation (GO:0033005)3.34847616
60granulocyte activation (GO:0036230)3.32574164
61detection of bacterium (GO:0016045)3.31625944
62regulation of dendritic cell antigen processing and presentation (GO:0002604)3.27927259
63glycosphingolipid catabolic process (GO:0046479)3.26981504
64cellular response to thyroid hormone stimulus (GO:0097067)3.26766119
65positive regulation of gamma-delta T cell activation (GO:0046645)3.26471285
66NIK/NF-kappaB signaling (GO:0038061)3.26386539
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.24841559
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.24841559
69regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.23240439
70defense response to protozoan (GO:0042832)3.23158311
71lipopolysaccharide-mediated signaling pathway (GO:0031663)3.21540270
72positive regulation of cholesterol efflux (GO:0010875)3.21428146
73response to interferon-alpha (GO:0035455)3.19712404
74regulation of podosome assembly (GO:0071801)3.17335391
75amino sugar catabolic process (GO:0046348)3.17108844
76negative regulation of lipid storage (GO:0010888)3.15247684
77negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.15044492
78regulation of chronic inflammatory response (GO:0002676)3.14051287
79regulation of mononuclear cell migration (GO:0071675)3.13872056
80negative regulation of interleukin-12 production (GO:0032695)3.13328585
81regulation of T cell tolerance induction (GO:0002664)3.12821021
82cellular response to type I interferon (GO:0071357)3.12431966
83type I interferon signaling pathway (GO:0060337)3.12431966
84regulation of chemokine biosynthetic process (GO:0045073)3.11171633
85response to type I interferon (GO:0034340)3.10360071
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09996779
87myeloid dendritic cell activation (GO:0001773)3.09684716
88regulation of interferon-beta production (GO:0032648)3.09326086
89response to protozoan (GO:0001562)3.08815894
90mannose metabolic process (GO:0006013)3.06211697
91regulation of gamma-delta T cell activation (GO:0046643)3.05786163
92neutrophil mediated immunity (GO:0002446)3.04770052
93antigen processing and presentation of endogenous antigen (GO:0019883)3.04591432
94positive regulation of heat generation (GO:0031652)3.03722728
95cellular response to interferon-gamma (GO:0071346)3.03698346
96positive regulation of mast cell degranulation (GO:0043306)3.03304728
97positive regulation of mast cell activation involved in immune response (GO:0033008)3.03304728
98regulation of T-helper 2 cell differentiation (GO:0045628)3.03182774
99negative regulation of viral genome replication (GO:0045071)3.01313858
100regulation of type 2 immune response (GO:0002828)3.01309166
101regulation of interleukin-12 production (GO:0032655)3.00338530
102negative regulation of nitric oxide biosynthetic process (GO:0045019)2.98812325
103negative regulation of erythrocyte differentiation (GO:0045647)2.98491012
104regulation of leukocyte degranulation (GO:0043300)2.98073326
105regulation of vitamin metabolic process (GO:0030656)2.97268173
106germinal center formation (GO:0002467)2.96905658
107cellular response to interferon-alpha (GO:0035457)2.95815655
108regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95492109
109regulation of macrophage chemotaxis (GO:0010758)2.94400229
110hydrogen peroxide biosynthetic process (GO:0050665)2.93657131
111superoxide anion generation (GO:0042554)2.92302208
112glycolipid catabolic process (GO:0019377)2.92056364
113interferon-gamma-mediated signaling pathway (GO:0060333)2.91698970
114adhesion of symbiont to host cell (GO:0044650)2.91516973
115virion attachment to host cell (GO:0019062)2.91516973
116negative regulation of production of molecular mediator of immune response (GO:0002701)2.90684928
117response to interferon-gamma (GO:0034341)2.90077822
118oligosaccharide catabolic process (GO:0009313)2.89826327
119regulation of type I interferon-mediated signaling pathway (GO:0060338)2.89422089
120negative regulation of phagocytosis (GO:0050765)2.88779781
121positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.88465575
122regulation of fever generation (GO:0031620)2.85895702
123detection of biotic stimulus (GO:0009595)2.85692559
124regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.85678673
125dendritic cell differentiation (GO:0097028)2.85053340
126cellular response to lipopolysaccharide (GO:0071222)2.83246393
127positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.82886876
128N-acetylneuraminate metabolic process (GO:0006054)2.82801732
129positive regulation of cholesterol transport (GO:0032376)2.80987050
130positive regulation of sterol transport (GO:0032373)2.80987050
131hyaluronan catabolic process (GO:0030214)2.79317021
132low-density lipoprotein particle clearance (GO:0034383)2.78685637
133positive regulation of B cell differentiation (GO:0045579)2.77517638
134detection of external biotic stimulus (GO:0098581)2.75213200
135negative regulation of interleukin-6 production (GO:0032715)2.73773560
136myeloid leukocyte activation (GO:0002274)2.71637886
137positive regulation of leukocyte degranulation (GO:0043302)2.70542951
138regulation of interferon-gamma biosynthetic process (GO:0045072)2.67877600
139natural killer cell mediated immunity (GO:0002228)2.66181641
140natural killer cell mediated cytotoxicity (GO:0042267)2.66181641
141negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.65816053
142negative regulation of myeloid cell apoptotic process (GO:0033033)2.65554300
143cellular extravasation (GO:0045123)2.64599196
144adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.63951344
145positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.63365542
146response to lipoprotein particle (GO:0055094)2.62835753
147positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.62408443
148reactive oxygen species biosynthetic process (GO:1903409)2.61728053
149toxin transport (GO:1901998)2.60980272
150positive regulation of chemokine production (GO:0032722)2.59727378
151negative regulation of interleukin-17 production (GO:0032700)2.54911079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.64881940
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.24941067
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.33960968
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.45107527
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.21692955
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.70813271
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.59965554
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.45434033
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.38289221
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07804574
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.95550052
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.61354938
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51652602
14GATA1_22025678_ChIP-Seq_K562_Human2.51110211
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.50742486
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35703489
17SPI1_23547873_ChIP-Seq_NB4_Human2.34931166
18* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.22377593
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.22004316
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06948072
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05488537
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.04280013
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.03793067
24SPI1_23127762_ChIP-Seq_K562_Human1.88482586
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86707104
26SCL_19346495_ChIP-Seq_HPC-7_Human1.86566144
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85168509
28* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.78286315
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76715221
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76632569
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74758607
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71745540
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68262902
34PU_27001747_Chip-Seq_BMDM_Mouse1.67878548
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.67388894
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66930513
37VDR_24763502_ChIP-Seq_THP-1_Human1.66362613
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64014162
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62885716
40* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62223798
41E2F7_22180533_ChIP-Seq_HELA_Human1.61822350
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.58982961
43LXR_22292898_ChIP-Seq_THP-1_Human1.57769393
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54396636
45VDR_24787735_ChIP-Seq_THP-1_Human1.50147693
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49756875
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.49176390
48VDR_21846776_ChIP-Seq_THP-1_Human1.47051738
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44987003
50CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42126110
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42007523
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41191641
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.37899199
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37438603
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36959980
56MAF_26560356_Chip-Seq_TH1_Human1.36797939
57MYB_26560356_Chip-Seq_TH2_Human1.33789377
58KDM2B_26808549_Chip-Seq_DND41_Human1.31658893
59* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31086287
60TFEB_21752829_ChIP-Seq_HELA_Human1.30978331
61MYB_26560356_Chip-Seq_TH1_Human1.29850722
62RUNX_20019798_ChIP-Seq_JUKART_Human1.29628390
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28331205
64* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28309202
65PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28003188
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27253281
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25070122
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21615310
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21128619
70* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20909129
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.20050572
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19181537
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18671523
74GATA1_19941826_ChIP-Seq_K562_Human1.17214236
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15821910
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14253134
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.13441656
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12366429
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09914373
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07565408
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02201645
82STAT1_20625510_ChIP-Seq_HELA_Human1.01892258
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99981719
84* GATA3_26560356_Chip-Seq_TH2_Human0.97619425
85UTX_26944678_Chip-Seq_JUKART_Human0.97358286
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96642076
87ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95988050
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95806293
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94527184
90BCL6_27268052_Chip-Seq_Bcells_Human0.93406869
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93348216
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93197451
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92464287
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91866703
95ESR1_21235772_ChIP-Seq_MCF-7_Human0.91367248
96BCOR_27268052_Chip-Seq_Bcells_Human0.90104948
97GATA3_27048872_Chip-Seq_THYMUS_Human0.88897136
98MAF_26560356_Chip-Seq_TH2_Human0.87827493
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87694150
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87498413
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85770328
102KDM2B_26808549_Chip-Seq_K562_Human0.85528820
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.85417466
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84844486
105SPI1_20517297_ChIP-Seq_HL60_Human0.83984821
106MYC_22102868_ChIP-Seq_BL_Human0.83566898
107ELK3_25401928_ChIP-Seq_HUVEC_Human0.82287478
108TCF7_22412390_ChIP-Seq_EML_Mouse0.81547323
109RACK7_27058665_Chip-Seq_MCF-7_Human0.80526190
110* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78263131
111HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76988850
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75321513
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.74439180
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.70104368
115SRF_21415370_ChIP-Seq_HL-1_Mouse0.68653942
116PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67288934
117TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67189508
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.66154941
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.64451157
120PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.60649942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.47039949
2MP0001835_abnormal_antigen_presentation3.75813035
3MP0009840_abnormal_foam_cell3.29642771
4MP0003436_decreased_susceptibility_to3.27125935
5MP0003191_abnormal_cellular_cholesterol3.16140834
6MP0003172_abnormal_lysosome_physiology3.07581860
7MP0004510_myositis3.04532922
8* MP0002419_abnormal_innate_immunity3.03400963
9MP0006082_CNS_inflammation2.64330082
10MP0003303_peritoneal_inflammation2.56331347
11MP0002148_abnormal_hypersensitivity_rea2.46943478
12* MP0005000_abnormal_immune_tolerance2.45336853
13MP0000569_abnormal_digit_pigmentation2.43647164
14MP0005025_abnormal_response_to2.41439556
15MP0003724_increased_susceptibility_to2.39060045
16MP0009785_altered_susceptibility_to2.38109388
17* MP0005387_immune_system_phenotype2.35839051
18* MP0001790_abnormal_immune_system2.35839051
19* MP0002452_abnormal_antigen_presenting2.30101496
20MP0005464_abnormal_platelet_physiology2.18791654
21MP0002139_abnormal_hepatobiliary_system2.11610062
22* MP0001800_abnormal_humoral_immune2.06489548
23* MP0002723_abnormal_immune_serum2.05289752
24MP0001533_abnormal_skeleton_physiology1.94717513
25MP0005451_abnormal_body_composition1.91300783
26* MP0001819_abnormal_immune_cell1.86522258
27* MP0002420_abnormal_adaptive_immunity1.85916552
28MP0003448_altered_tumor_morphology1.78906826
29MP0008469_abnormal_protein_level1.78009985
30MP0005671_abnormal_response_to1.75105198
31MP0008004_abnormal_stomach_pH1.73893219
32MP0000685_abnormal_immune_system1.72964393
33MP0008438_abnormal_cutaneous_collagen1.72449842
34MP0002405_respiratory_system_inflammati1.72190402
35MP0005670_abnormal_white_adipose1.71572779
36MP0001853_heart_inflammation1.68958119
37MP0005174_abnormal_tail_pigmentation1.66679286
38MP0001845_abnormal_inflammatory_respons1.65506448
39MP0009278_abnormal_bone_marrow1.62893746
40MP0000343_altered_response_to1.60802580
41MP0005257_abnormal_intraocular_pressure1.59847985
42MP0003300_gastrointestinal_ulcer1.58112348
43MP0009764_decreased_sensitivity_to1.56916450
44MP0004947_skin_inflammation1.54722448
45MP0003806_abnormal_nucleotide_metabolis1.53313755
46MP0005167_abnormal_blood-brain_barrier1.47032787
47MP0003183_abnormal_peptide_metabolism1.43655436
48MP0003690_abnormal_glial_cell1.42562465
49MP0004782_abnormal_surfactant_physiolog1.40853529
50MP0002998_abnormal_bone_remodeling1.39617021
51* MP0000689_abnormal_spleen_morphology1.36441362
52* MP0000716_abnormal_immune_system1.34040090
53MP0003453_abnormal_keratinocyte_physiol1.33003805
54MP0000015_abnormal_ear_pigmentation1.30007465
55MP0000604_amyloidosis1.28011457
56MP0006054_spinal_hemorrhage1.24914500
57MP0002332_abnormal_exercise_endurance1.23251052
58MP0010307_abnormal_tumor_latency1.23211444
59MP0002398_abnormal_bone_marrow1.21631235
60MP0002933_joint_inflammation1.19728460
61MP0005397_hematopoietic_system_phenotyp1.19274950
62MP0001545_abnormal_hematopoietic_system1.19274950
63MP0000465_gastrointestinal_hemorrhage1.18988991
64MP0000858_altered_metastatic_potential1.17275686
65MP0003075_altered_response_to1.15953964
66MP0005076_abnormal_cell_differentiation1.14109787
67MP0002722_abnormal_immune_system1.12505539
68* MP0002429_abnormal_blood_cell1.11933280
69MP0003566_abnormal_cell_adhesion1.11817781
70MP0005390_skeleton_phenotype1.10128711
71MP0005310_abnormal_salivary_gland1.09001307
72MP0009333_abnormal_splenocyte_physiolog1.07192080
73MP0000371_diluted_coat_color1.06438842
74MP0003186_abnormal_redox_activity1.05170903
75MP0010155_abnormal_intestine_physiology1.05068808
76MP0001851_eye_inflammation1.04118353
77MP0009763_increased_sensitivity_to1.03360039
78MP0001542_abnormal_bone_strength1.03322008
79MP0005164_abnormal_response_to1.02765542
80MP0002277_abnormal_respiratory_mucosa1.00852299
81MP0010329_abnormal_lipoprotein_level0.96758329
82MP0002254_reproductive_system_inflammat0.96620209
83MP0004883_abnormal_blood_vessel0.94909766
84MP0000609_abnormal_liver_physiology0.93484277
85MP0000920_abnormal_myelination0.93059237
86MP0001873_stomach_inflammation0.92962968
87MP0003828_pulmonary_edema0.92125036
88MP0002138_abnormal_hepatobiliary_system0.92105603
89MP0005083_abnormal_biliary_tract0.92024343
90MP0002166_altered_tumor_susceptibility0.86709611
91MP0005165_increased_susceptibility_to0.86351407
92MP0002396_abnormal_hematopoietic_system0.84999708
93MP0001663_abnormal_digestive_system0.82702815
94MP0003091_abnormal_cell_migration0.82520051
95MP0003705_abnormal_hypodermis_morpholog0.82388232
96MP0002132_abnormal_respiratory_system0.80704251
97MP0005166_decreased_susceptibility_to0.80621395
98MP0002006_tumorigenesis0.78398327
99MP0003011_delayed_dark_adaptation0.76902199
100MP0003879_abnormal_hair_cell0.76777703
101MP0001958_emphysema0.76350445
102MP0002136_abnormal_kidney_physiology0.74476739
103MP0003795_abnormal_bone_structure0.74229101
104MP0003763_abnormal_thymus_physiology0.73792110
105MP0005319_abnormal_enzyme/_coenzyme0.73274836
106MP0003329_amyloid_beta_deposits0.73212683
107MP0000598_abnormal_liver_morphology0.72280500
108MP0009115_abnormal_fat_cell0.71826190
109MP0000249_abnormal_blood_vessel0.71388999
110MP0003656_abnormal_erythrocyte_physiolo0.71247481
111MP0008260_abnormal_autophagy0.71221790
112MP0003195_calcinosis0.70390206
113MP0009765_abnormal_xenobiotic_induced0.70277559
114MP0008874_decreased_physiological_sensi0.68181134
115MP0010386_abnormal_urinary_bladder0.67539577
116MP0004019_abnormal_vitamin_homeostasis0.66867273
117MP0002090_abnormal_vision0.64814152
118MP0005334_abnormal_fat_pad0.64384910
119MP0000767_abnormal_smooth_muscle0.64126583
120MP0000490_abnormal_crypts_of0.63936245
121MP0005023_abnormal_wound_healing0.63677604
122MP0005365_abnormal_bile_salt0.63343376
123MP0005647_abnormal_sex_gland0.61575657
124MP0005535_abnormal_body_temperature0.60992208
125MP0005666_abnormal_adipose_tissue0.59436573
126MP0003279_aneurysm0.55201783
127MP0004808_abnormal_hematopoietic_stem0.53653479
128MP0001501_abnormal_sleep_pattern0.53015786
129MP0005584_abnormal_enzyme/coenzyme_acti0.51288803

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.36319433
2Recurrent abscess formation (HP:0002722)6.24258475
3Increased cerebral lipofuscin (HP:0011813)5.68421814
4Vacuolated lymphocytes (HP:0001922)5.56523699
5Recurrent bacterial skin infections (HP:0005406)5.44682302
6Recurrent gram-negative bacterial infections (HP:0005420)5.28530499
7Eczematoid dermatitis (HP:0000976)5.10999796
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.80318517
9Dysostosis multiplex (HP:0000943)4.58079369
10Abnormality of macrophages (HP:0004311)4.56540888
11Glomerulonephritis (HP:0000099)4.47145049
12Abnormality of liposaccharide metabolism (HP:0010968)4.33001515
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.33001515
14Abnormality of glycolipid metabolism (HP:0010969)4.33001515
15Urinary glycosaminoglycan excretion (HP:0003541)3.89944518
16Mucopolysacchariduria (HP:0008155)3.89944518
17Mutism (HP:0002300)3.89106491
18Abnormality of mucopolysaccharide metabolism (HP:0011020)3.87860509
19Abnormality of polysaccharide metabolism (HP:0011012)3.87860509
20Abnormality of glycosaminoglycan metabolism (HP:0004371)3.87860509
21Gingivitis (HP:0000230)3.69060408
22Joint hemorrhage (HP:0005261)3.68329832
23Complement deficiency (HP:0004431)3.66340935
24Autoimmune thrombocytopenia (HP:0001973)3.45775437
25Abnormality of complement system (HP:0005339)3.40296310
26Myocardial infarction (HP:0001658)3.39951475
27Mediastinal lymphadenopathy (HP:0100721)3.31318467
28Orchitis (HP:0100796)3.29438443
29Myositis (HP:0100614)3.28633229
30Recurrent skin infections (HP:0001581)3.24419558
31Nuclear cataract (HP:0100018)3.21061412
32Loss of speech (HP:0002371)3.16002470
33Periodontitis (HP:0000704)3.11567931
34Prostate neoplasm (HP:0100787)3.08301490
35Axonal loss (HP:0003447)2.97667702
36Keratoconjunctivitis (HP:0001096)2.93633777
37Elevated erythrocyte sedimentation rate (HP:0003565)2.92879174
38Chronic obstructive pulmonary disease (HP:0006510)2.90306903
39Obstructive lung disease (HP:0006536)2.90306903
40Neurofibrillary tangles (HP:0002185)2.88531032
41Nephritis (HP:0000123)2.87140286
42Purpura (HP:0000979)2.86876836
43Disinhibition (HP:0000734)2.85664181
44Recurrent fungal infections (HP:0002841)2.82436198
45Retrobulbar optic neuritis (HP:0100654)2.80150109
46Optic neuritis (HP:0100653)2.80150109
47Spontaneous hematomas (HP:0007420)2.77547797
48Hepatosplenomegaly (HP:0001433)2.75581903
49Pathologic fracture (HP:0002756)2.73591569
50Hemoptysis (HP:0002105)2.68338672
51Increased serum ferritin (HP:0003281)2.68064009
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.54620208
53Neuronal loss in central nervous system (HP:0002529)2.53594448
54Upper motor neuron abnormality (HP:0002127)2.51346109
55Abnormality of the vasculature of the conjunctiva (HP:0008054)2.49912932
56J-shaped sella turcica (HP:0002680)2.48976927
57Thick nail (HP:0001805)2.48498718
58IgM deficiency (HP:0002850)2.43579685
59Recurrent viral infections (HP:0004429)2.43405954
60Hematochezia (HP:0002573)2.43239164
61Inappropriate behavior (HP:0000719)2.43126742
62Apathy (HP:0000741)2.41594716
63Increased IgM level (HP:0003496)2.40858277
64Diminished motivation (HP:0000745)2.35732460
65Basal ganglia calcification (HP:0002135)2.35726524
66Asymmetric septal hypertrophy (HP:0001670)2.35712003
67Gingival bleeding (HP:0000225)2.34621196
68Pustule (HP:0200039)2.33616845
69Gangrene (HP:0100758)2.29370189
70Malnutrition (HP:0004395)2.29135679
71Agnosia (HP:0010524)2.27923095
72Encephalitis (HP:0002383)2.27770837
73Polyneuropathy (HP:0001271)2.26005397
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.23879611
75Osteolytic defects of the hand bones (HP:0009699)2.23879611
76Petechiae (HP:0000967)2.23697405
77Abnormality of iron homeostasis (HP:0011031)2.23697266
78Vasculitis (HP:0002633)2.22330021
79Stomatitis (HP:0010280)2.21914744
80Urticaria (HP:0001025)2.18490720
81Epistaxis (HP:0000421)2.17258446
82Pulmonary embolism (HP:0002204)2.16658326
83Osteomyelitis (HP:0002754)2.16441857
84Thoracic kyphosis (HP:0002942)2.14965716
85Gastrointestinal infarctions (HP:0005244)2.14760084
86Conjunctival telangiectasia (HP:0000524)2.14289529
87Recurrent pneumonia (HP:0006532)2.14069784
88Interstitial pulmonary disease (HP:0006530)2.13028071
89Prolonged bleeding time (HP:0003010)2.11097455
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.10804665
91Bone pain (HP:0002653)2.10737250
92Menorrhagia (HP:0000132)2.09317008
93Increased IgE level (HP:0003212)2.08792265
94Personality changes (HP:0000751)2.08667908
95Cellulitis (HP:0100658)2.07280849
96Progressive visual loss (HP:0000529)2.06856691
97Leukocytosis (HP:0001974)2.06323765
98Hypergammaglobulinemia (HP:0010702)2.05614800
99Memory impairment (HP:0002354)2.04225085
100Chronic mucocutaneous candidiasis (HP:0002728)2.04216980
101Recurrent cutaneous fungal infections (HP:0011370)2.04216980
102Cerebral inclusion bodies (HP:0100314)2.04186097
103Nausea (HP:0002018)2.03386029
104T lymphocytopenia (HP:0005403)2.03002744
105Chronic otitis media (HP:0000389)1.99915762
106Vertigo (HP:0002321)1.97161238
107Pulmonary infiltrates (HP:0002113)1.97064466
108Abnormality of the pleura (HP:0002103)1.96925503
109Dementia (HP:0000726)1.94063338
110Abnormality of the nasal mucosa (HP:0000433)1.93170674
111Acne (HP:0001061)1.92916810
112Vertebral compression fractures (HP:0002953)1.92080398
113Deformed sella turcica (HP:0002681)1.90493505
114Metaphyseal irregularity (HP:0003025)1.90184285
115Amyloidosis (HP:0011034)1.88689893
116Abnormality of T cell number (HP:0011839)1.88183920
117Peripheral demyelination (HP:0011096)1.86750123
118Progressive neurologic deterioration (HP:0002344)1.86164297
119Retinal atrophy (HP:0001105)1.85635042
120Poor head control (HP:0002421)1.85143350
121Abnormality of the pericardium (HP:0001697)1.84174612
122Meningitis (HP:0001287)1.83994770
123Abnormality of the prostate (HP:0008775)1.82663575
124Tetraparesis (HP:0002273)1.82591552
125Recurrent lower respiratory tract infections (HP:0002783)1.81806607
126Albinism (HP:0001022)1.81554369
127Keratoconjunctivitis sicca (HP:0001097)1.79599418
128Hypercholesterolemia (HP:0003124)1.79408063
129Arterial thrombosis (HP:0004420)1.78574270
130Abnormality of the lumbar spine (HP:0100712)1.76439585
131Inflammation of the large intestine (HP:0002037)1.75618758
132Colitis (HP:0002583)1.74555389
133Absent frontal sinuses (HP:0002688)1.73497462
134Anorexia (HP:0002039)1.72892091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.81971243
2MAP4K14.04003637
3IRAK43.81476885
4TYK23.43456677
5BLK3.01667440
6KIT2.97300507
7ERN12.80626163
8MAP3K142.75699656
9TBK12.75016547
10TGFBR22.60635219
11IKBKE2.33250427
12DDR22.10721934
13CAMK1D2.04450178
14RIPK41.96903173
15TAOK11.91241289
16TXK1.80258863
17JAK11.80207484
18JAK31.72602523
19IKBKB1.71655203
20TAOK31.71173134
21ZAK1.62851026
22CSF1R1.57921294
23CDC42BPA1.54479939
24CSK1.49843872
25MAP2K31.46928798
26ZAP701.45306553
27HCK1.29912604
28NEK91.28963341
29MAP3K31.27941584
30ABL21.25875801
31PLK41.20340425
32STK101.13750594
33SYK1.13401221
34IRAK11.12958008
35FES1.12551744
36CAMK1G1.11059944
37TTN1.08425696
38MAP3K11.07212577
39TNK21.05822749
40FGR1.05497416
41ADRBK21.04454263
42BTK1.03336587
43CHUK1.03334669
44LYN1.01599717
45TEC0.96976136
46RPS6KA40.96764845
47IRAK20.94951398
48PIM10.93482701
49EIF2AK20.93477318
50JAK20.93165146
51RPS6KA60.91549627
52GRK70.91213070
53CLK10.89342040
54CDK120.88887652
55FGFR40.88370837
56MARK30.86415921
57ACVR1B0.86262633
58LCK0.86134335
59PIM20.85890801
60RPS6KC10.83844072
61RPS6KL10.83844072
62EPHB10.78405445
63CAMKK20.78256862
64EPHA30.73099760
65MATK0.72826821
66YES10.69184963
67TAOK20.69036601
68CDK60.68618478
69NME20.65031717
70MAP2K60.63936159
71TESK20.62971715
72KDR0.61364294
73TRPM70.61203302
74BMPR20.60823064
75PAK40.60274656
76ABL10.60100444
77PRKCD0.59634312
78MAPK70.57704694
79FGFR30.57289771
80INSRR0.56745382
81MARK20.56727972
82PDPK10.56331181
83HIPK20.55234128
84MAP3K110.55015593
85DAPK20.55010680
86TYRO30.54313518
87MAP3K130.53568208
88SGK30.53249721
89MAPK40.52365773
90TESK10.51337632
91EGFR0.51283411
92PDK10.50767361
93BRD40.50374091
94SIK30.50226198
95SIK10.47577455
96MAP3K60.46693750
97PTK60.45914318
98TRIB30.44722270
99MAP3K50.44261337
100PRPF4B0.37802621
101MOS0.37748453
102STK40.35547631
103FYN0.35253940
104PRKD20.35028320
105ICK0.33339188
106RIPK10.31983263
107PDGFRA0.31866246
108STK240.31822062
109SGK20.31663593
110ITK0.30650920
111BMX0.30362382
112GRK10.30337816
113ARAF0.30214549
114MAP2K20.29532204
115SIK20.29402667
116RPS6KA20.28789163
117PRKCH0.28617172
118DYRK30.28016141
119GRK60.27655717
120PKN10.27465356
121MAPK120.27423354
122BMPR1B0.27372718
123MAPKAPK20.26702205
124ATR0.26606305
125IGF1R0.26485504
126DYRK1B0.25762216

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.66045533
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.96023089
3Lysosome_Homo sapiens_hsa041423.35646911
4Other glycan degradation_Homo sapiens_hsa005113.34044762
5Leishmaniasis_Homo sapiens_hsa051402.95916817
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.52544813
7Osteoclast differentiation_Homo sapiens_hsa043802.32271478
8Pertussis_Homo sapiens_hsa051332.31751088
9Malaria_Homo sapiens_hsa051442.20332260
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.19405508
11Tuberculosis_Homo sapiens_hsa051522.18269155
12Complement and coagulation cascades_Homo sapiens_hsa046102.18211671
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08704319
14Caffeine metabolism_Homo sapiens_hsa002321.94795803
15Phagosome_Homo sapiens_hsa041451.92594936
16Legionellosis_Homo sapiens_hsa051341.90434935
17Measles_Homo sapiens_hsa051621.87388996
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76405619
19Type I diabetes mellitus_Homo sapiens_hsa049401.76049641
20Influenza A_Homo sapiens_hsa051641.68626982
21B cell receptor signaling pathway_Homo sapiens_hsa046621.66190703
22Rheumatoid arthritis_Homo sapiens_hsa053231.65394231
23Antigen processing and presentation_Homo sapiens_hsa046121.56788446
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49938349
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48892512
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41387813
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33643191
28Herpes simplex infection_Homo sapiens_hsa051681.32012888
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30849122
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.29819688
31Toxoplasmosis_Homo sapiens_hsa051451.29652235
32Apoptosis_Homo sapiens_hsa042101.26286502
33TNF signaling pathway_Homo sapiens_hsa046681.22264302
34Hematopoietic cell lineage_Homo sapiens_hsa046401.21845234
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14308960
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11885125
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11670954
38Shigellosis_Homo sapiens_hsa051311.10953442
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05691394
40Hepatitis C_Homo sapiens_hsa051601.04334827
41Salmonella infection_Homo sapiens_hsa051321.01978450
42Asthma_Homo sapiens_hsa053100.96198422
43Jak-STAT signaling pathway_Homo sapiens_hsa046300.95682934
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93613206
45Chemokine signaling pathway_Homo sapiens_hsa040620.93387227
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92817202
47Sphingolipid metabolism_Homo sapiens_hsa006000.87973945
48Hepatitis B_Homo sapiens_hsa051610.87786934
49ABC transporters_Homo sapiens_hsa020100.86500755
50Graft-versus-host disease_Homo sapiens_hsa053320.84439939
51Allograft rejection_Homo sapiens_hsa053300.83565050
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.83485331
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.79481455
54Acute myeloid leukemia_Homo sapiens_hsa052210.77964801
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76130230
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75253923
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68341857
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66913951
59Bladder cancer_Homo sapiens_hsa052190.65777847
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.64513493
61Prion diseases_Homo sapiens_hsa050200.63451790
62PPAR signaling pathway_Homo sapiens_hsa033200.63331917
63African trypanosomiasis_Homo sapiens_hsa051430.61863197
64Epstein-Barr virus infection_Homo sapiens_hsa051690.61676821
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59355225
66* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54981460
67beta-Alanine metabolism_Homo sapiens_hsa004100.53925002
68Collecting duct acid secretion_Homo sapiens_hsa049660.53229407
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.53131025
70VEGF signaling pathway_Homo sapiens_hsa043700.52804793
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52774659
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50869079
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50275931
74Histidine metabolism_Homo sapiens_hsa003400.49712959
75Amoebiasis_Homo sapiens_hsa051460.49644361
76Galactose metabolism_Homo sapiens_hsa000520.49444178
77Pancreatic cancer_Homo sapiens_hsa052120.48886662
78Chronic myeloid leukemia_Homo sapiens_hsa052200.48700463
79One carbon pool by folate_Homo sapiens_hsa006700.46555091
80Primary immunodeficiency_Homo sapiens_hsa053400.46318346
81Starch and sucrose metabolism_Homo sapiens_hsa005000.46029052
82Renin-angiotensin system_Homo sapiens_hsa046140.45982994
83Type II diabetes mellitus_Homo sapiens_hsa049300.45894941
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45324157
85Arachidonic acid metabolism_Homo sapiens_hsa005900.44683014
86Mineral absorption_Homo sapiens_hsa049780.43373842
87Peroxisome_Homo sapiens_hsa041460.40730911
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.39255653
89Notch signaling pathway_Homo sapiens_hsa043300.39083093
90Viral myocarditis_Homo sapiens_hsa054160.38403204
91Endocytosis_Homo sapiens_hsa041440.37457041
92Base excision repair_Homo sapiens_hsa034100.37154264
93Vibrio cholerae infection_Homo sapiens_hsa051100.34068532
94T cell receptor signaling pathway_Homo sapiens_hsa046600.33356623
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33036831
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32953693
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32176406
98Platelet activation_Homo sapiens_hsa046110.32170980
99Systemic lupus erythematosus_Homo sapiens_hsa053220.31918916
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.27694125
101Phenylalanine metabolism_Homo sapiens_hsa003600.27345171
102Pyrimidine metabolism_Homo sapiens_hsa002400.26384862
103HIF-1 signaling pathway_Homo sapiens_hsa040660.25546109
104Autoimmune thyroid disease_Homo sapiens_hsa053200.25392168
105Viral carcinogenesis_Homo sapiens_hsa052030.22183352
106GnRH signaling pathway_Homo sapiens_hsa049120.21347660
107Lysine degradation_Homo sapiens_hsa003100.21221334
108Renal cell carcinoma_Homo sapiens_hsa052110.20954811
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20593602
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20457252
111Dorso-ventral axis formation_Homo sapiens_hsa043200.20435860
112Insulin resistance_Homo sapiens_hsa049310.20311623
113Vitamin digestion and absorption_Homo sapiens_hsa049770.20279791
114HTLV-I infection_Homo sapiens_hsa051660.19690519
115Prolactin signaling pathway_Homo sapiens_hsa049170.19574019
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.19466086
117FoxO signaling pathway_Homo sapiens_hsa040680.16850456
118Tryptophan metabolism_Homo sapiens_hsa003800.16575725
119Fructose and mannose metabolism_Homo sapiens_hsa000510.16333613
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14905985
121MAPK signaling pathway_Homo sapiens_hsa040100.13463185

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