SHOX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* chondrocyte development (GO:0002063)5.70478792
2collagen fibril organization (GO:0030199)4.98662498
3chromosome condensation (GO:0030261)4.73410896
4bone trabecula formation (GO:0060346)4.54006535
5DNA packaging (GO:0006323)4.37175924
6chondrocyte proliferation (GO:0035988)4.36631616
7metanephric mesenchyme development (GO:0072075)4.34547666
8* cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.33112737
9acrosome reaction (GO:0007340)4.07713427
10peripheral nervous system neuron development (GO:0048935)4.04019717
11body morphogenesis (GO:0010171)4.03249838
12axonal fasciculation (GO:0007413)4.02639394
13kidney mesenchyme development (GO:0072074)4.00222922
14* embryonic skeletal joint morphogenesis (GO:0060272)3.98569959
15peptidyl-proline hydroxylation (GO:0019511)3.94726114
16embryonic cranial skeleton morphogenesis (GO:0048701)3.92868856
17tooth mineralization (GO:0034505)3.86179001
18limb bud formation (GO:0060174)3.82547038
19neuron projection extension involved in neuron projection guidance (GO:1902284)3.82501897
20axon extension involved in axon guidance (GO:0048846)3.82501897
21embryonic body morphogenesis (GO:0010172)3.79685449
22response to pheromone (GO:0019236)3.78901800
23skin morphogenesis (GO:0043589)3.76170703
24neuron recognition (GO:0008038)3.73860335
25spermatid nucleus differentiation (GO:0007289)3.71381909
26negative regulation of catenin import into nucleus (GO:0035414)3.59411325
27craniofacial suture morphogenesis (GO:0097094)3.55089215
28mesenchymal-epithelial cell signaling (GO:0060638)3.53834090
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.52692942
30middle ear morphogenesis (GO:0042474)3.52256714
31regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.48978033
32protein heterotrimerization (GO:0070208)3.48509740
33protein hydroxylation (GO:0018126)3.46662160
34sequestering of extracellular ligand from receptor (GO:0035581)3.45958317
35head development (GO:0060322)3.43340400
36extracellular fibril organization (GO:0043206)3.36735645
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.34397573
38negative regulation of axon extension involved in axon guidance (GO:0048843)3.33178719
39COPI coating of Golgi vesicle (GO:0048205)3.32574475
40Golgi transport vesicle coating (GO:0048200)3.32574475
41neuron cell-cell adhesion (GO:0007158)3.25601210
42endocardial cushion development (GO:0003197)3.23977240
43outer ear morphogenesis (GO:0042473)3.21592192
44negative regulation of chondrocyte differentiation (GO:0032331)3.20918539
45neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.20742711
46lateral sprouting from an epithelium (GO:0060601)3.20582039
47regulation of axon extension involved in axon guidance (GO:0048841)3.18601623
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.17455897
49outflow tract septum morphogenesis (GO:0003148)3.17436250
50protein retention in ER lumen (GO:0006621)3.13338485
51cranial nerve morphogenesis (GO:0021602)3.12424875
52* embryonic forelimb morphogenesis (GO:0035115)3.08372922
53cartilage condensation (GO:0001502)3.07584183
54cell aggregation (GO:0098743)3.07584183
55regulation of non-canonical Wnt signaling pathway (GO:2000050)3.07352509
56neural crest cell development (GO:0014032)3.04238252
57plasma membrane repair (GO:0001778)3.04118516
58regulation of heart morphogenesis (GO:2000826)3.02451913
59generation of neurons (GO:0048699)3.01199559
60multicellular organismal macromolecule metabolic process (GO:0044259)3.01149945
61notochord development (GO:0030903)2.95254514
62regulation of axon guidance (GO:1902667)2.95189985
63extracellular matrix assembly (GO:0085029)2.95122604
64negative regulation of axon guidance (GO:1902668)2.94346715
65microtubule depolymerization (GO:0007019)2.93936706
66regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.93863868
67dermatan sulfate biosynthetic process (GO:0030208)2.93364432
68nuclear pore complex assembly (GO:0051292)2.92388605
69multicellular organismal catabolic process (GO:0044243)2.88955574
70* forelimb morphogenesis (GO:0035136)2.88625670
71cell migration in hindbrain (GO:0021535)2.87344301
72regulation of cardioblast proliferation (GO:0003264)2.86216594
73regulation of secondary heart field cardioblast proliferation (GO:0003266)2.86216594
74regulation of early endosome to late endosome transport (GO:2000641)2.85157616
75camera-type eye morphogenesis (GO:0048593)2.83944801
76* positive regulation of mesenchymal cell proliferation (GO:0002053)2.83925517
77axon extension (GO:0048675)2.83302453
78cell migration involved in sprouting angiogenesis (GO:0002042)2.83036359
79* regulation of mesenchymal cell proliferation (GO:0010464)2.83022711
80fusion of sperm to egg plasma membrane (GO:0007342)2.82445996
81negative regulation of skeletal muscle tissue development (GO:0048642)2.79413816
82multicellular organismal metabolic process (GO:0044236)2.79297194
83Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.78981910
84gonadal mesoderm development (GO:0007506)2.78939306
85cranial suture morphogenesis (GO:0060363)2.78704705
86neurofilament cytoskeleton organization (GO:0060052)2.77823336
87eyelid development in camera-type eye (GO:0061029)2.77224921
88hippo signaling (GO:0035329)2.77174986
89pattern specification involved in kidney development (GO:0061004)2.77170913
90negative regulation of DNA repair (GO:0045738)2.76544256
91apoptotic cell clearance (GO:0043277)2.76398064
92positive regulation of cartilage development (GO:0061036)2.76161396
93* embryonic skeletal system morphogenesis (GO:0048704)2.75275633
94organ induction (GO:0001759)2.75062357
95collagen catabolic process (GO:0030574)2.74413986
96extracellular regulation of signal transduction (GO:1900115)2.73524806
97extracellular negative regulation of signal transduction (GO:1900116)2.73524806
98G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.73481173
99negative regulation of cartilage development (GO:0061037)2.73465583
100mesenchymal cell proliferation (GO:0010463)2.73408426
101mesenchymal cell development (GO:0014031)2.72544539
102cell migration involved in heart development (GO:0060973)2.72413557
103establishment of planar polarity (GO:0001736)2.71894160
104establishment of tissue polarity (GO:0007164)2.71894160
105proximal/distal pattern formation (GO:0009954)2.71612345
106regulation of establishment of planar polarity (GO:0090175)2.71050425
107negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.69899041
108layer formation in cerebral cortex (GO:0021819)2.69811844
109collagen metabolic process (GO:0032963)2.69738911
110negative regulation of embryonic development (GO:0045992)2.69600079
111regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.69441643
112fibril organization (GO:0097435)2.68367017
113cochlea morphogenesis (GO:0090103)2.66446980
114mesenchyme morphogenesis (GO:0072132)2.66426880
115short-term memory (GO:0007614)2.66337590
116binding of sperm to zona pellucida (GO:0007339)2.65533844
117hyaluronan catabolic process (GO:0030214)2.65099057
118negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.64949028
119embryonic viscerocranium morphogenesis (GO:0048703)2.64909177
120* cartilage development (GO:0051216)2.63736975
121negative regulation of fatty acid transport (GO:2000192)2.63445463
122endocardial cushion morphogenesis (GO:0003203)2.63437688
123palate development (GO:0060021)2.62978559
124dermatan sulfate metabolic process (GO:0030205)2.62425303
125coronary vasculature morphogenesis (GO:0060977)2.62229612
126regulation of mitotic spindle organization (GO:0060236)2.61950418
127hindlimb morphogenesis (GO:0035137)2.61942625
128cell proliferation involved in metanephros development (GO:0072203)2.61651321
129convergent extension (GO:0060026)2.61362743
130* regulation of chondrocyte differentiation (GO:0032330)2.61338690
131regulation of catenin import into nucleus (GO:0035412)2.60327657
132sympathetic nervous system development (GO:0048485)2.59164537
133* regulation of cartilage development (GO:0061035)2.59108850
134endodermal cell differentiation (GO:0035987)2.58774777
135dendritic spine morphogenesis (GO:0060997)2.57487617
136positive regulation of fibroblast migration (GO:0010763)2.56597440
137negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.56580454
138branching involved in prostate gland morphogenesis (GO:0060442)2.56048907
139negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.56035527
140positive regulation of gastrulation (GO:2000543)2.56011737
141proteoglycan metabolic process (GO:0006029)2.55434329
142face morphogenesis (GO:0060325)2.55395449
143blood vessel maturation (GO:0001955)2.52066681
144regulation of cardioblast differentiation (GO:0051890)2.52038782
145mesenchymal cell differentiation involved in renal system development (GO:2001012)2.51730705
146mesenchymal cell differentiation involved in kidney development (GO:0072161)2.51730705
147pericardium development (GO:0060039)2.51683989
148type B pancreatic cell proliferation (GO:0044342)2.51301508
149glomerular visceral epithelial cell development (GO:0072015)2.51257739
150mitotic chromosome condensation (GO:0007076)2.50086609
151sperm motility (GO:0030317)2.49532988
152positive regulation of blood vessel endothelial cell migration (GO:0043536)2.49178217
153paraxial mesoderm development (GO:0048339)2.48076709
154vascular endothelial growth factor signaling pathway (GO:0038084)2.48026274
155smooth muscle tissue development (GO:0048745)2.47406715
156dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46842393
157stress fiber assembly (GO:0043149)2.46240247
158microtubule polymerization or depolymerization (GO:0031109)2.45335472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.73606382
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.61757162
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.59460586
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.20563909
5* EED_16625203_ChIP-ChIP_MESCs_Mouse3.07806915
6* EZH2_27304074_Chip-Seq_ESCs_Mouse3.03078341
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.02626007
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.94773186
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.86956116
10* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85054714
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82869653
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82869653
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.82108230
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80254890
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61366681
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53228696
17BRD4_25478319_ChIP-Seq_HGPS_Human2.51823466
18* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.50562404
19* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49567269
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40579689
21* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38935544
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37343026
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.34976792
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.33896555
25* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.28597428
26* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.27144239
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.25351112
28AR_21572438_ChIP-Seq_LNCaP_Human2.21298887
29WT1_19549856_ChIP-ChIP_CCG9911_Human2.21089058
30* RNF2_27304074_Chip-Seq_ESCs_Mouse2.17661864
31* CBX2_27304074_Chip-Seq_ESCs_Mouse2.13138589
32E2F7_22180533_ChIP-Seq_HELA_Human2.11857276
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.09888410
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08694176
35CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06677503
36GBX2_23144817_ChIP-Seq_PC3_Human2.06481853
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.05595605
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02798382
39UBF1/2_26484160_Chip-Seq_HMECs_Human2.02651256
40EGR1_19374776_ChIP-ChIP_THP-1_Human2.01724820
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.99067557
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95818372
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.94699293
44* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92908648
45TP53_22127205_ChIP-Seq_IMR90_Human1.86219902
46LXR_22292898_ChIP-Seq_THP-1_Human1.82252384
47* TP53_20018659_ChIP-ChIP_R1E_Mouse1.80897339
48NFIB_24661679_ChIP-Seq_LUNG_Mouse1.79023764
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.78724516
50CLOCK_20551151_ChIP-Seq_293T_Human1.78279039
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.78068365
52ZNF274_21170338_ChIP-Seq_K562_Hela1.74149989
53TP53_18474530_ChIP-ChIP_U2OS_Human1.73879967
54* EZH2_27294783_Chip-Seq_ESCs_Mouse1.72514870
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71219877
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.68960913
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68321504
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67289713
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67272295
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65925769
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63962431
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.63668967
63* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63483121
64* TP63_19390658_ChIP-ChIP_HaCaT_Human1.61127808
65* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60320027
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59364745
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55112000
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53967299
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50701226
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48311689
71* RNF2_27304074_Chip-Seq_NSC_Mouse1.44754869
72FUS_26573619_Chip-Seq_HEK293_Human1.44754718
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44590437
74P300_19829295_ChIP-Seq_ESCs_Human1.44300536
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44240414
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.42463210
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.42439854
78EWS_26573619_Chip-Seq_HEK293_Human1.42333180
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41074709
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40059520
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39803359
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39577737
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39347305
84ATF3_27146783_Chip-Seq_COLON_Human1.37860790
85* RING1B_27294783_Chip-Seq_NPCs_Mouse1.37710548
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37127439
87SA1_22415368_ChIP-Seq_MEFs_Mouse1.36836246
88AR_21909140_ChIP-Seq_LNCAP_Human1.36626841
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36136439
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35911396
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35759954
92TAF15_26573619_Chip-Seq_HEK293_Human1.35598782
93SMAD4_21799915_ChIP-Seq_A2780_Human1.35147479
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34926118
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34926118
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34660359
97KDM2B_26808549_Chip-Seq_K562_Human1.33525682
98* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33392238
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33299696
100TP53_23651856_ChIP-Seq_MEFs_Mouse1.32418698
101SMC1_22415368_ChIP-Seq_MEFs_Mouse1.32128781
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.31517360
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29976679
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.29855678
105NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.29513250
106RACK7_27058665_Chip-Seq_MCF-7_Human1.28146923
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28070746
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27861667
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27534597
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27396278
111FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27278569
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26946298
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25295968
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24278231
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22082117
116TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21466757
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20665085
118ELF1_20517297_ChIP-Seq_JURKAT_Human1.20255915
119ISL1_27105846_Chip-Seq_CPCs_Mouse1.18057350
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17293719
121* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16173153
122IGF1R_20145208_ChIP-Seq_DFB_Human1.15824538
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14930083
124* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14823778
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14820271
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13186561
127SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11949185
128NCOR1_26117541_ChIP-Seq_K562_Human1.11740897
129* CJUN_26792858_Chip-Seq_BT549_Human1.11698366
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11154525
131TP53_16413492_ChIP-PET_HCT116_Human1.10630618
132RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09409996
133AHR_22903824_ChIP-Seq_MCF-7_Human1.09378495
134KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08348205
135TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08248047
136NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08225887
137KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08020864
138* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06983500
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06706138
140SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06215987
141BCAT_22108803_ChIP-Seq_LS180_Human1.05524361
142ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05003524
143TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04688868
144SOX2_21211035_ChIP-Seq_LN229_Gbm1.04014395
145JUN_21703547_ChIP-Seq_K562_Human1.02081427
146TET1_21490601_ChIP-Seq_MESCs_Mouse1.01982685
147* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01955976
148FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01837121
149ER_23166858_ChIP-Seq_MCF-7_Human1.01378301
150CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99460293
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.98491553
152AR_19668381_ChIP-Seq_PC3_Human0.98035623
153THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98003196
154MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97534390
155* RUNX2_22187159_ChIP-Seq_PCA_Human0.97146428
156SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96854983
157SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96854983
158POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96848482
159RXR_22108803_ChIP-Seq_LS180_Human0.96209501
160TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96023005
161EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94783874
162ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94559458
163* VDR_21846776_ChIP-Seq_THP-1_Human0.93817060
164KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93440947
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93276802
166DROSHA_22980978_ChIP-Seq_HELA_Human0.93174796
167SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92853073
168CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91884080
169SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91807545
170HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91738722
171PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91375781
172DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91215394
173NFI_21473784_ChIP-Seq_ESCs_Mouse0.90842684
174ERG_21242973_ChIP-ChIP_JURKAT_Human0.90566400
175ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90346737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.46613985
2MP0008438_abnormal_cutaneous_collagen3.86053377
3MP0003122_maternal_imprinting3.76440466
4MP0009250_abnormal_appendicular_skeleto3.19088984
5MP0010030_abnormal_orbit_morphology2.87632864
6MP0003880_abnormal_central_pattern2.77934387
7MP0001299_abnormal_eye_distance/2.62384274
8MP0003385_abnormal_body_wall2.56332592
9MP0002282_abnormal_trachea_morphology2.51414678
10MP0005275_abnormal_skin_tensile2.49843411
11MP0009053_abnormal_anal_canal2.22135467
12MP0004134_abnormal_chest_morphology2.21525461
13MP0003942_abnormal_urinary_system2.09678327
14MP0003950_abnormal_plasma_membrane2.09630875
15MP0003123_paternal_imprinting2.07500464
16MP0003121_genomic_imprinting2.06193562
17MP0005171_absent_coat_pigmentation2.04445414
18MP0000049_abnormal_middle_ear2.02796956
19MP0005410_abnormal_fertilization2.02166540
20MP0002877_abnormal_melanocyte_morpholog2.01456657
21* MP0003755_abnormal_palate_morphology2.00187660
22MP0005508_abnormal_skeleton_morphology1.92584660
23MP0005623_abnormal_meninges_morphology1.88896514
24MP0000537_abnormal_urethra_morphology1.86675905
25MP0006276_abnormal_autonomic_nervous1.86649080
26MP0000762_abnormal_tongue_morphology1.82675886
27MP0003937_abnormal_limbs/digits/tail_de1.81004668
28MP0000534_abnormal_ureter_morphology1.77974270
29MP0004272_abnormal_basement_membrane1.76287707
30MP0002060_abnormal_skin_morphology1.71505625
31* MP0000163_abnormal_cartilage_morphology1.68782949
32MP0002896_abnormal_bone_mineralization1.68145872
33* MP0002115_abnormal_skeleton_extremities1.67991517
34MP0002233_abnormal_nose_morphology1.66150072
35MP0000751_myopathy1.63711614
36MP0002116_abnormal_craniofacial_bone1.55794896
37MP0000428_abnormal_craniofacial_morphol1.52326561
38* MP0002109_abnormal_limb_morphology1.49671646
39MP0002108_abnormal_muscle_morphology1.47384403
40MP0002932_abnormal_joint_morphology1.44547097
41MP0002249_abnormal_larynx_morphology1.44325810
42* MP0003935_abnormal_craniofacial_develop1.43771677
43MP0003566_abnormal_cell_adhesion1.43473596
44MP0003705_abnormal_hypodermis_morpholog1.43409244
45MP0003279_aneurysm1.42083460
46MP0001348_abnormal_lacrimal_gland1.41818465
47MP0003283_abnormal_digestive_organ1.39967142
48* MP0002113_abnormal_skeleton_development1.39875002
49MP0002938_white_spotting1.39712046
50MP0010368_abnormal_lymphatic_system1.35911280
51MP0005257_abnormal_intraocular_pressure1.33076790
52MP0000767_abnormal_smooth_muscle1.32605267
53MP0009384_cardiac_valve_regurgitation1.31461311
54MP0001243_abnormal_dermal_layer1.31297124
55MP0000778_abnormal_nervous_system1.27910230
56MP0005187_abnormal_penis_morphology1.26174206
57MP0001542_abnormal_bone_strength1.26122189
58MP0000432_abnormal_head_morphology1.25063724
59MP0005023_abnormal_wound_healing1.23067054
60MP0000759_abnormal_skeletal_muscle1.20888178
61MP0005076_abnormal_cell_differentiation1.20514385
62MP0002184_abnormal_innervation1.20258156
63MP0002114_abnormal_axial_skeleton1.18341528
64MP0000749_muscle_degeneration1.17827621
65MP0002089_abnormal_postnatal_growth/wei1.17365871
66MP0000516_abnormal_urinary_system1.15272896
67MP0005367_renal/urinary_system_phenotyp1.15272896
68MP0004270_analgesia1.14370783
69MP0008789_abnormal_olfactory_epithelium1.13972830
70MP0001270_distended_abdomen1.10119221
71MP0000566_synostosis1.09766278
72MP0001958_emphysema1.06840602
73MP0009780_abnormal_chondrocyte_physiolo1.05465546
74MP0002177_abnormal_outer_ear1.02689883
75MP0000733_abnormal_muscle_development1.02387480
76MP0005670_abnormal_white_adipose1.01482932
77MP0005058_abnormal_lysosome_morphology0.99073670
78MP0002933_joint_inflammation0.96110490
79MP0004145_abnormal_muscle_electrophysio0.95008964
80MP0003941_abnormal_skin_development0.94995416
81MP0002751_abnormal_autonomic_nervous0.93971912
82MP0002734_abnormal_mechanical_nocicepti0.93639096
83MP0002111_abnormal_tail_morphology0.91726375
84MP0010352_gastrointestinal_tract_polyps0.90650175
85MP0004859_abnormal_synaptic_plasticity0.89582191
86MP0003635_abnormal_synaptic_transmissio0.89534011
87MP0000003_abnormal_adipose_tissue0.89129592
88MP0003077_abnormal_cell_cycle0.88971787
89MP0005390_skeleton_phenotype0.88581883
90MP0005248_abnormal_Harderian_gland0.88085615
91MP0001968_abnormal_touch/_nociception0.87735442
92MP0000678_abnormal_parathyroid_gland0.87236202
93MP0003115_abnormal_respiratory_system0.87217428
94MP0000750_abnormal_muscle_regeneration0.86240392
95MP0003938_abnormal_ear_development0.85956345
96MP0001340_abnormal_eyelid_morphology0.84247301
97MP0000747_muscle_weakness0.83783759
98MP0002081_perinatal_lethality0.82943107
99MP0008932_abnormal_embryonic_tissue0.81718185
100MP0005595_abnormal_vascular_smooth0.79445435
101MP0009703_decreased_birth_body0.79206417
102MP0001293_anophthalmia0.77679709
103MP0003861_abnormal_nervous_system0.77148112
104MP0000955_abnormal_spinal_cord0.76793603
105MP0003111_abnormal_nucleus_morphology0.76708623
106MP0001943_abnormal_respiration0.76361282
107MP0006138_congestive_heart_failure0.74781425
108MP0005193_abnormal_anterior_eye0.74112759
109MP0001177_atelectasis0.73672128
110MP0002085_abnormal_embryonic_tissue0.73663297
111MP0000538_abnormal_urinary_bladder0.73517277
112MP0002084_abnormal_developmental_patter0.73399170
113MP0000681_abnormal_thyroid_gland0.73379960
114MP0005394_taste/olfaction_phenotype0.72967543
115MP0005499_abnormal_olfactory_system0.72967543
116MP0005451_abnormal_body_composition0.72689719
117MP0001849_ear_inflammation0.71225721
118MP0004233_abnormal_muscle_weight0.70420490
119MP0003315_abnormal_perineum_morphology0.70013293
120MP0004197_abnormal_fetal_growth/weight/0.69495922
121MP0005197_abnormal_uvea_morphology0.68009742
122* MP0002925_abnormal_cardiovascular_devel0.68003260
123MP0001286_abnormal_eye_development0.67743578
124MP0002837_dystrophic_cardiac_calcinosis0.67371390
125MP0001879_abnormal_lymphatic_vessel0.66793245
126MP0009046_muscle_twitch0.66732275
127MP0010386_abnormal_urinary_bladder0.66366027
128MP0002295_abnormal_pulmonary_circulatio0.66154536
129MP0004858_abnormal_nervous_system0.66035594
130MP0004510_myositis0.65513783
131MP0003091_abnormal_cell_migration0.65328926
132MP0004084_abnormal_cardiac_muscle0.65185128
133MP0005330_cardiomyopathy0.65031266
134MP0008007_abnormal_cellular_replicative0.64387576
135MP0002822_catalepsy0.63087382
136MP0005369_muscle_phenotype0.62975114
137MP0006054_spinal_hemorrhage0.62544558
138MP0004883_abnormal_blood_vessel0.62330187
139* MP0001614_abnormal_blood_vessel0.62313162
140MP0000631_abnormal_neuroendocrine_gland0.62105610
141MP0002269_muscular_atrophy0.61582677
142MP0001175_abnormal_lung_morphology0.61321902
143MP0003698_abnormal_male_reproductive0.60078119
144MP0004036_abnormal_muscle_relaxation0.58713124
145MP0004087_abnormal_muscle_fiber0.58165959
146MP0000350_abnormal_cell_proliferation0.57915984
147MP0005408_hypopigmentation0.56456687

Predicted human phenotypes

RankGene SetZ-score
1Hypoplastic ischia (HP:0003175)4.38917070
2Vitreoretinal degeneration (HP:0000655)4.38294479
3Abnormality of the ischium (HP:0003174)4.29056475
4Premature rupture of membranes (HP:0001788)4.04544819
5Protrusio acetabuli (HP:0003179)3.90424943
6Neonatal short-limb short stature (HP:0008921)3.84162594
7Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.80250430
8Epiphyseal dysplasia (HP:0002656)3.76297052
9Cupped ribs (HP:0000887)3.59819747
10Spinal rigidity (HP:0003306)3.56347599
11Irregular epiphyses (HP:0010582)3.39036876
12Aortic aneurysm (HP:0004942)3.35312841
13Mesomelia (HP:0003027)3.17585904
14Microglossia (HP:0000171)3.13064460
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.10946237
16Short 4th metacarpal (HP:0010044)3.10946237
17Shallow orbits (HP:0000586)3.10311266
18Bowel diverticulosis (HP:0005222)3.04502308
19Cervical subluxation (HP:0003308)3.02212933
20Vascular tortuosity (HP:0004948)2.95473447
21Wrist flexion contracture (HP:0001239)2.91641543
22Flat capital femoral epiphysis (HP:0003370)2.85634785
23Bell-shaped thorax (HP:0001591)2.79848246
24Slender build (HP:0001533)2.78998419
25Dilatation of the ascending aorta (HP:0005111)2.68728936
26Abnormality of the 4th metacarpal (HP:0010012)2.68337408
27Short nail (HP:0001799)2.67064869
28Abnormality of the 2nd finger (HP:0004100)2.61407534
29Abnormality of the phalanges of the 2nd finger (HP:0009541)2.60659606
30Morphological abnormality of the middle ear (HP:0008609)2.55082140
31Biconcave vertebral bodies (HP:0004586)2.54861779
32Tracheomalacia (HP:0002779)2.54372787
33Broad long bones (HP:0005622)2.53420315
34Vertebral compression fractures (HP:0002953)2.52760144
35Osteoarthritis (HP:0002758)2.51513956
36Abnormality of the pubic bones (HP:0003172)2.50126160
37Abnormality of dentin (HP:0010299)2.49339346
38Joint laxity (HP:0001388)2.48181954
39Mild short stature (HP:0003502)2.44742630
40Exostoses (HP:0100777)2.43355417
41Abnormal tarsal ossification (HP:0008369)2.41676535
42Broad phalanx (HP:0006009)2.41302955
43Increased connective tissue (HP:0009025)2.39002722
44Increased variability in muscle fiber diameter (HP:0003557)2.38784956
45Soft skin (HP:0000977)2.36822448
46Small epiphyses (HP:0010585)2.35441934
47Infantile muscular hypotonia (HP:0008947)2.34464130
48Wide anterior fontanel (HP:0000260)2.33456557
49Abnormality of the phalanges of the 5th finger (HP:0004213)2.33326118
50Limited hip movement (HP:0008800)2.32561405
51Delayed epiphyseal ossification (HP:0002663)2.31320499
52Coronal craniosynostosis (HP:0004440)2.30449028
53Abnormality of the acetabulum (HP:0003170)2.28987073
54Spondylolisthesis (HP:0003302)2.28591709
55Hyperextensible skin (HP:0000974)2.28194746
56Arterial tortuosity (HP:0005116)2.26490594
57Ankle contracture (HP:0006466)2.26471921
58Asymmetry of the thorax (HP:0001555)2.25608379
59Broad metatarsal (HP:0001783)2.25397511
60Hypoventilation (HP:0002791)2.23845279
61Abnormal delivery (HP:0001787)2.23783158
62Renal duplication (HP:0000075)2.23540585
63Broad thumb (HP:0011304)2.23165746
64Abnormality of the fetal cardiovascular system (HP:0010948)2.23147711
65Abnormal umbilical cord blood vessels (HP:0011403)2.23147711
66Single umbilical artery (HP:0001195)2.23147711
67Atrophic scars (HP:0001075)2.18863501
68Hip contracture (HP:0003273)2.16658858
69Mitral regurgitation (HP:0001653)2.15872825
70Sparse lateral eyebrow (HP:0005338)2.14774108
71Cerebral aneurysm (HP:0004944)2.13987901
72Spinal cord compression (HP:0002176)2.13857273
73Follicular hyperkeratosis (HP:0007502)2.13388092
74Aortic regurgitation (HP:0001659)2.12647676
75Hyperacusis (HP:0010780)2.11531173
76Aortic dissection (HP:0002647)2.11326367
77Breech presentation (HP:0001623)2.10694134
78Short clavicles (HP:0000894)2.10681618
79Natal tooth (HP:0000695)2.09873040
80Mitral valve prolapse (HP:0001634)2.09775128
81Wormian bones (HP:0002645)2.09457788
82Cutaneous finger syndactyly (HP:0010554)2.08836254
83Abnormality of the umbilical cord (HP:0010881)2.08796590
84Round ear (HP:0100830)2.08115399
85Disproportionate tall stature (HP:0001519)2.07848789
86Entropion (HP:0000621)2.07485676
87Abnormality of the parietal bone (HP:0002696)2.07362523
88Flat cornea (HP:0007720)2.07334443
89Broad finger (HP:0001500)2.06983013
90Ectopia lentis (HP:0001083)2.04392588
91Mildly elevated creatine phosphokinase (HP:0008180)2.03742080
92Osteolytic defects of the hand bones (HP:0009699)2.02038260
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.02038260
94Turricephaly (HP:0000262)2.01925729
95Short 5th finger (HP:0009237)2.01130110
96Broad phalanges of the hand (HP:0009768)2.00758212
97Thin ribs (HP:0000883)1.99556697
98Genu recurvatum (HP:0002816)1.99242903
99Abnormality of the proximal phalanges of the hand (HP:0009834)1.98558011
100Absent frontal sinuses (HP:0002688)1.97539660
101Asymmetric septal hypertrophy (HP:0001670)1.96294405
102Fibular hypoplasia (HP:0003038)1.95786172
103Hallux valgus (HP:0001822)1.95380247
104Short middle phalanx of the 5th finger (HP:0004220)1.95138380
105Type 1 muscle fiber predominance (HP:0003803)1.94558918
106Thoracolumbar scoliosis (HP:0002944)1.94143592
107Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.92991691
108Delayed cranial suture closure (HP:0000270)1.92753389
109Abnormal ossification of hand bones (HP:0005921)1.92610224
110Hepatoblastoma (HP:0002884)1.92512366
111Abnormality of carpal bone ossification (HP:0006257)1.92424504
112Long clavicles (HP:0000890)1.92076003
113Abnormality of skeletal muscle fiber size (HP:0012084)1.90447651
114Peritonitis (HP:0002586)1.89706375
115Ulnar bowing (HP:0003031)1.89121231
116Midline defect of the nose (HP:0004122)1.88791247
117Calcaneovalgus deformity (HP:0001848)1.88315334
118Overgrowth (HP:0001548)1.87738468
119Narrow nasal bridge (HP:0000446)1.86722834
120Fragile skin (HP:0001030)1.85439155
121Buphthalmos (HP:0000557)1.84879277
122Thin bony cortex (HP:0002753)1.84602969
123Abnormal hand bone ossification (HP:0010660)1.84502319
124Dislocated radial head (HP:0003083)1.84374101
125Generalized amyotrophy (HP:0003700)1.83286307
126Abnormality of the middle phalanges of the hand (HP:0009833)1.83209693
127Inguinal hernia (HP:0000023)1.82991036
128Abnormality of the radial head (HP:0003995)1.82939335
129Venous abnormality (HP:0002624)1.82382223
130Broad face (HP:0000283)1.82048868
131Abnormality of the phalanges of the hallux (HP:0010057)1.81322881
132Deviation of the hallux (HP:0010051)1.81081627
133Aplasia/Hypoplasia of the fibula (HP:0006492)1.80978734
134Elbow flexion contracture (HP:0002987)1.80908076
135Hypoplasia of the iris (HP:0007676)1.80317384
136Long toe (HP:0010511)1.80155691
137Deformed tarsal bones (HP:0008119)1.80009532
138Bladder diverticulum (HP:0000015)1.79727033
139Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.79646419
140Abnormality of the nasal septum (HP:0000419)1.78913430
141Aplasia/Hypoplasia of the clavicles (HP:0006710)1.77642412
142Abnormal vertebral ossification (HP:0100569)1.77458509
143Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76792282
144Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.76417047
145Broad toe (HP:0001837)1.76110094
146Achilles tendon contracture (HP:0001771)1.75962350
147Synostosis of carpal bones (HP:0005048)1.75658787
148Nonimmune hydrops fetalis (HP:0001790)1.75580449
149Abnormality of the aortic arch (HP:0012303)1.75029720
150Cutaneous syndactyly (HP:0012725)1.74919065
151Short middle phalanx of finger (HP:0005819)1.74548566
152Blue sclerae (HP:0000592)1.74538455
153Abnormality of incisor morphology (HP:0011063)1.74506819
154Renovascular hypertension (HP:0100817)1.73980058
155Metaphyseal cupping (HP:0003021)1.73925768
156Abnormal foot bone ossification (HP:0010675)1.73381415
157Atelectasis (HP:0100750)1.73076350
158Abnormality of skull ossification (HP:0002703)1.72798996
159Convex nasal ridge (HP:0000444)1.72797318
160Syringomyelia (HP:0003396)1.72574128
161Spinal cord lesions (HP:0100561)1.72574128
162Protruding ear (HP:0000411)1.71953358
163Nuclear cataract (HP:0100018)1.70228833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.94209848
2PLK44.13349799
3TNIK3.53665976
4LATS23.37776200
5TESK13.10448321
6PBK3.00914114
7NTRK32.72729390
8ICK2.58956353
9MAPK132.58684363
10TRIB32.49272020
11MARK12.44963560
12MYLK2.28113072
13CASK2.27127978
14ERBB32.24064447
15NEK92.21154169
16UHMK12.06695322
17EPHB22.02269653
18EPHA32.01584632
19PDGFRA2.01171509
20LATS11.93483657
21SIK21.85347523
22MINK11.79070989
23ERBB41.69437873
24PAK31.68713876
25MAP3K41.67674944
26WNK11.66288923
27IRAK31.61426968
28EEF2K1.57188519
29PRKD31.38340219
30NME21.37683026
31STK381.34894639
32MOS1.32397921
33WEE11.32365920
34MAP3K61.30487788
35DYRK21.29509033
36FER1.26346689
37PLK21.26072800
38LIMK11.25867490
39ROCK11.24960786
40AKT31.24470922
41PAK41.22891781
42PAK61.22005757
43SIK11.21205904
44MAP3K121.20519567
45BRSK11.19261996
46EPHA41.15816371
47TTN1.15519931
48MAP3K81.14133831
49MAP2K71.12554392
50CDC42BPA1.11918026
51CSNK1A1L1.11403542
52CDK121.10439215
53FGFR11.09766950
54SIK31.09457094
55BMPR1B1.08787881
56MAP2K41.07659077
57FGFR21.04228189
58MAP2K31.04170840
59BRD41.03603468
60ABL21.03050397
61NEK21.02415162
62CDK71.01685118
63NTRK21.01645643
64ADRBK11.00254748
65BRSK20.99720506
66FRK0.99551627
67MAP3K90.99074515
68PIK3CA0.98949767
69PHKG20.96313533
70PHKG10.96313533
71BCR0.94947009
72ILK0.94328232
73KSR10.93894979
74FLT30.92929180
75TTK0.92210639
76PNCK0.92070173
77NTRK10.92047535
78PAK20.89990847
79PRKG20.87167409
80BUB10.86930731
81TRIM280.86436473
82PIK3CG0.84921319
83NLK0.84252733
84WNK30.84210432
85CDK140.81303595
86PRKD20.80585092
87PRKCG0.79618552
88PDK20.78906933
89STK390.77845396
90EIF2AK10.77625152
91RIPK10.75388037
92ROCK20.75330864
93MET0.75271247
94CHEK20.74232651
95MAPK70.74197515
96MAP3K100.73493632
97KSR20.72801072
98CDK180.72464769
99TYRO30.72440959
100CSNK1G10.71288350
101CAMK1G0.70887857
102CDK150.70548810
103PRKCH0.69855730
104CSNK1G30.69013424
105ALK0.68672161
106ERN10.68128794
107GRK50.68056815
108PDPK10.67350497
109CDK50.64984500
110PAK10.64505001
111PKN20.64481460
112MKNK20.61505002
113KIT0.60649475
114SMG10.60057988
115MKNK10.59842177
116NME10.59721974
117GRK70.59575297
118DYRK1A0.59254784
119BRAF0.58269547
120PTK2B0.58218892
121CAMK2A0.57915902
122CDK11A0.57013776
123MAP3K30.56664742
124CHEK10.55891962
125SRPK10.55666336
126CSNK1G20.55244031
127MST1R0.55026835
128CAMK1D0.53741400
129PTK20.53647059
130MAPK100.51605659
131PRKCE0.51451085
132WNK40.50519486
133MAPK110.48949328
134STK38L0.48916823
135MAPK90.48248903
136STK30.48036201
137CDK90.47500471
138STK100.47230818
139CSNK1E0.46860106
140TLK10.46767541
141GSK3A0.45365873
142PDGFRB0.44816231
143TGFBR20.44341068
144DMPK0.44248578
145MAPK80.43580048
146TRPM70.41731500
147INSRR0.41550666
148PLK30.41527731
149CDK80.41343943
150STK40.41058528
151CLK10.40657932
152AURKA0.39615081
153MAPK10.39427569
154ZAK0.37364824
155MTOR0.35997147
156PRKG10.35299296
157RPS6KB10.35008547
158INSR0.34495979
159RPS6KA20.33124784
160PIM20.32504108
161MAP2K10.31731187
162PRKCZ0.31344870

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.75617288
2Basal cell carcinoma_Homo sapiens_hsa052172.34504155
3Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.31880118
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.30165025
5Axon guidance_Homo sapiens_hsa043602.18493614
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.17698597
7Hedgehog signaling pathway_Homo sapiens_hsa043402.12534699
8Nicotine addiction_Homo sapiens_hsa050332.03274454
9Protein digestion and absorption_Homo sapiens_hsa049741.91334346
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90336152
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89553813
12Olfactory transduction_Homo sapiens_hsa047401.81249626
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72548983
14Melanogenesis_Homo sapiens_hsa049161.71998727
15Gap junction_Homo sapiens_hsa045401.71015854
16Wnt signaling pathway_Homo sapiens_hsa043101.68765229
17Focal adhesion_Homo sapiens_hsa045101.68534581
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64452691
19Dilated cardiomyopathy_Homo sapiens_hsa054141.62047824
20Circadian entrainment_Homo sapiens_hsa047131.61705309
21Hippo signaling pathway_Homo sapiens_hsa043901.60645749
22GABAergic synapse_Homo sapiens_hsa047271.50364778
23Dopaminergic synapse_Homo sapiens_hsa047281.45749850
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.45000264
25Cardiac muscle contraction_Homo sapiens_hsa042601.44528402
26Cell cycle_Homo sapiens_hsa041101.44475595
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43563155
28Proteoglycans in cancer_Homo sapiens_hsa052051.43495308
29Long-term potentiation_Homo sapiens_hsa047201.41691558
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38906368
31RNA transport_Homo sapiens_hsa030131.38380034
32Long-term depression_Homo sapiens_hsa047301.38224231
33Renin secretion_Homo sapiens_hsa049241.35224821
34Glioma_Homo sapiens_hsa052141.34716039
35Adherens junction_Homo sapiens_hsa045201.33861663
36Glutamatergic synapse_Homo sapiens_hsa047241.33744213
37Small cell lung cancer_Homo sapiens_hsa052221.32590434
38TGF-beta signaling pathway_Homo sapiens_hsa043501.30947195
39Other glycan degradation_Homo sapiens_hsa005111.30404245
40Estrogen signaling pathway_Homo sapiens_hsa049151.29324630
41Cholinergic synapse_Homo sapiens_hsa047251.26948629
42Morphine addiction_Homo sapiens_hsa050321.25925538
43GnRH signaling pathway_Homo sapiens_hsa049121.25340126
44Taste transduction_Homo sapiens_hsa047421.25102060
45Serotonergic synapse_Homo sapiens_hsa047261.22692755
46PI3K-Akt signaling pathway_Homo sapiens_hsa041511.20634624
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20568063
48Nucleotide excision repair_Homo sapiens_hsa034201.18250748
49Melanoma_Homo sapiens_hsa052181.15726656
50Colorectal cancer_Homo sapiens_hsa052101.14052357
51Synaptic vesicle cycle_Homo sapiens_hsa047211.13287359
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12775174
53Pancreatic cancer_Homo sapiens_hsa052121.12474780
54MicroRNAs in cancer_Homo sapiens_hsa052061.11600941
55Insulin secretion_Homo sapiens_hsa049111.10375979
56mRNA surveillance pathway_Homo sapiens_hsa030151.09650974
57Cocaine addiction_Homo sapiens_hsa050301.06883645
58Oocyte meiosis_Homo sapiens_hsa041141.05963227
59Prostate cancer_Homo sapiens_hsa052151.05894752
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03682483
61Basal transcription factors_Homo sapiens_hsa030221.03338798
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.99435470
63Oxytocin signaling pathway_Homo sapiens_hsa049210.99202612
64Amphetamine addiction_Homo sapiens_hsa050310.98509581
65ErbB signaling pathway_Homo sapiens_hsa040120.97554816
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96109929
67Alcoholism_Homo sapiens_hsa050340.93863471
68Alzheimers disease_Homo sapiens_hsa050100.93589423
69Non-small cell lung cancer_Homo sapiens_hsa052230.93505360
70Salivary secretion_Homo sapiens_hsa049700.93356549
71Endometrial cancer_Homo sapiens_hsa052130.93242196
72Shigellosis_Homo sapiens_hsa051310.93233300
73Renal cell carcinoma_Homo sapiens_hsa052110.92372712
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91452589
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91363236
76Oxidative phosphorylation_Homo sapiens_hsa001900.89800117
77VEGF signaling pathway_Homo sapiens_hsa043700.89445286
78Endocytosis_Homo sapiens_hsa041440.89400666
79p53 signaling pathway_Homo sapiens_hsa041150.89318225
80N-Glycan biosynthesis_Homo sapiens_hsa005100.86960293
81Tight junction_Homo sapiens_hsa045300.86646261
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85865792
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85245853
84Gastric acid secretion_Homo sapiens_hsa049710.84666552
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84536528
86Rap1 signaling pathway_Homo sapiens_hsa040150.84313974
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83313374
88Malaria_Homo sapiens_hsa051440.82568568
89Acute myeloid leukemia_Homo sapiens_hsa052210.82371025
90Thyroid cancer_Homo sapiens_hsa052160.82290963
91Parkinsons disease_Homo sapiens_hsa050120.81200479
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80827516
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80731441
94Spliceosome_Homo sapiens_hsa030400.80723897
95Pathways in cancer_Homo sapiens_hsa052000.79354767
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78520689
97Ras signaling pathway_Homo sapiens_hsa040140.77973156
98Vibrio cholerae infection_Homo sapiens_hsa051100.77327223
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76557429
100Huntingtons disease_Homo sapiens_hsa050160.75784523
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75295959
102HTLV-I infection_Homo sapiens_hsa051660.74563316
103Phagosome_Homo sapiens_hsa041450.74408200
104One carbon pool by folate_Homo sapiens_hsa006700.73616968
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.73480181
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.73422659
107MAPK signaling pathway_Homo sapiens_hsa040100.73115093
108DNA replication_Homo sapiens_hsa030300.72980504
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71503592
110Amoebiasis_Homo sapiens_hsa051460.70663664
111cAMP signaling pathway_Homo sapiens_hsa040240.70663336
112Ovarian steroidogenesis_Homo sapiens_hsa049130.69197182
113Type II diabetes mellitus_Homo sapiens_hsa049300.68731171
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67961242
115Thyroid hormone synthesis_Homo sapiens_hsa049180.67682384
116Insulin signaling pathway_Homo sapiens_hsa049100.67113526
117Bladder cancer_Homo sapiens_hsa052190.64995629
118Viral carcinogenesis_Homo sapiens_hsa052030.64566407
119Notch signaling pathway_Homo sapiens_hsa043300.64236914
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63673558
121Calcium signaling pathway_Homo sapiens_hsa040200.61555447
122Lysosome_Homo sapiens_hsa041420.60586021
123Prolactin signaling pathway_Homo sapiens_hsa049170.59065559
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58699037
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58383644
126Dorso-ventral axis formation_Homo sapiens_hsa043200.58302827
127Hepatitis B_Homo sapiens_hsa051610.58072524
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.57905372
129Chronic myeloid leukemia_Homo sapiens_hsa052200.56235599
130Renin-angiotensin system_Homo sapiens_hsa046140.54265240
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54231078
132Glucagon signaling pathway_Homo sapiens_hsa049220.53530077
133Fanconi anemia pathway_Homo sapiens_hsa034600.52980378
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51049916
135mTOR signaling pathway_Homo sapiens_hsa041500.50764924
136Lysine degradation_Homo sapiens_hsa003100.48889302
137Prion diseases_Homo sapiens_hsa050200.47472296
138Pyrimidine metabolism_Homo sapiens_hsa002400.46207923
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45191675
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44041051
141Non-homologous end-joining_Homo sapiens_hsa034500.43841876
142Fatty acid biosynthesis_Homo sapiens_hsa000610.42872616
143AMPK signaling pathway_Homo sapiens_hsa041520.41096834
144Choline metabolism in cancer_Homo sapiens_hsa052310.40116826
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39274357

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