SHMT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.28540398
2mitotic chromosome condensation (GO:0007076)4.79873854
3* glycine metabolic process (GO:0006544)4.54064469
4* serine family amino acid biosynthetic process (GO:0009070)4.46529402
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.34707659
6L-phenylalanine metabolic process (GO:0006558)4.34707659
7mitotic sister chromatid segregation (GO:0000070)4.28408554
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.17963711
9L-phenylalanine catabolic process (GO:0006559)4.17963711
10establishment of integrated proviral latency (GO:0075713)4.11923928
11* tetrahydrofolate metabolic process (GO:0046653)4.06276749
12* serine family amino acid metabolic process (GO:0009069)3.98294811
13protein localization to chromosome, centromeric region (GO:0071459)3.93522614
14sister chromatid segregation (GO:0000819)3.93391477
15glyoxylate metabolic process (GO:0046487)3.91286731
16DNA unwinding involved in DNA replication (GO:0006268)3.91235029
17folic acid metabolic process (GO:0046655)3.90175364
18cysteine metabolic process (GO:0006534)3.89970026
19COPI coating of Golgi vesicle (GO:0048205)3.88533164
20Golgi transport vesicle coating (GO:0048200)3.88533164
21aromatic amino acid family catabolic process (GO:0009074)3.85243145
22* L-serine metabolic process (GO:0006563)3.83659257
23kynurenine metabolic process (GO:0070189)3.81075524
24serine family amino acid catabolic process (GO:0009071)3.79171076
25tRNA aminoacylation for protein translation (GO:0006418)3.69574374
26lysine metabolic process (GO:0006553)3.68188841
27lysine catabolic process (GO:0006554)3.68188841
28pteridine-containing compound biosynthetic process (GO:0042559)3.67423117
29peptidyl-arginine omega-N-methylation (GO:0035247)3.60520222
30amino acid activation (GO:0043038)3.59355336
31tRNA aminoacylation (GO:0043039)3.59355336
32indole-containing compound catabolic process (GO:0042436)3.55886949
33indolalkylamine catabolic process (GO:0046218)3.55886949
34tryptophan catabolic process (GO:0006569)3.55886949
35heterochromatin organization (GO:0070828)3.55433337
36mitotic metaphase plate congression (GO:0007080)3.53129525
37* one-carbon metabolic process (GO:0006730)3.52201230
38negative regulation of fibrinolysis (GO:0051918)3.49863005
39* folic acid-containing compound metabolic process (GO:0006760)3.48167926
40telomere maintenance via recombination (GO:0000722)3.45520842
41protein complex localization (GO:0031503)3.40712764
42urea cycle (GO:0000050)3.39447610
43urea metabolic process (GO:0019627)3.39447610
44regulation of translational fidelity (GO:0006450)3.33582785
45DNA strand elongation involved in DNA replication (GO:0006271)3.33036086
46IMP biosynthetic process (GO:0006188)3.32410159
47sulfur amino acid catabolic process (GO:0000098)3.32382772
48spliceosomal tri-snRNP complex assembly (GO:0000244)3.32330962
49tryptophan metabolic process (GO:0006568)3.32305904
50homocysteine metabolic process (GO:0050667)3.31105673
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.30686647
52alpha-linolenic acid metabolic process (GO:0036109)3.30215241
53regulation of translational elongation (GO:0006448)3.29833336
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.27927463
55nucleobase biosynthetic process (GO:0046112)3.27727593
56establishment of viral latency (GO:0019043)3.27541241
57ribonucleoprotein complex biogenesis (GO:0022613)3.25933135
58negative regulation of cholesterol transport (GO:0032375)3.24531754
59negative regulation of sterol transport (GO:0032372)3.24531754
60mitotic recombination (GO:0006312)3.23546284
61mitochondrial DNA metabolic process (GO:0032042)3.22433685
62ribosomal large subunit biogenesis (GO:0042273)3.22232798
63ribosomal small subunit assembly (GO:0000028)3.21517339
64protein localization to kinetochore (GO:0034501)3.21069759
65bile acid biosynthetic process (GO:0006699)3.20610199
66DNA topological change (GO:0006265)3.20002611
67nucleobase-containing small molecule interconversion (GO:0015949)3.19470168
68DNA replication initiation (GO:0006270)3.17732451
69histone arginine methylation (GO:0034969)3.16091637
70DNA strand elongation (GO:0022616)3.16039633
71DNA replication checkpoint (GO:0000076)3.15884635
72pore complex assembly (GO:0046931)3.15551207
73regulation of mammary gland epithelial cell proliferation (GO:0033599)3.13981232
74ribosome biogenesis (GO:0042254)3.11791511
75viral transcription (GO:0019083)3.11080719
76chromosome condensation (GO:0030261)3.10747415
77imidazole-containing compound metabolic process (GO:0052803)3.10672384
78nitrogen cycle metabolic process (GO:0071941)3.07635282
79translational termination (GO:0006415)3.06032696
80regulation of fibrinolysis (GO:0051917)3.05542487
81regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04105285
82cellular protein complex localization (GO:0034629)3.03302668
83regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02539302
84DNA duplex unwinding (GO:0032508)3.02219892
85SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.00768636
86formation of translation preinitiation complex (GO:0001731)2.99485926
87mitotic sister chromatid cohesion (GO:0007064)2.99455307
88mitotic nuclear envelope disassembly (GO:0007077)2.99387547
89* pteridine-containing compound metabolic process (GO:0042558)2.98855510
90amino-acid betaine metabolic process (GO:0006577)2.96689856
91regulation of protein activation cascade (GO:2000257)2.96132434
92alpha-amino acid catabolic process (GO:1901606)2.95102258
93IMP metabolic process (GO:0046040)2.94604682
94protein carboxylation (GO:0018214)2.93940502
95peptidyl-glutamic acid carboxylation (GO:0017187)2.93940502
96ribosome assembly (GO:0042255)2.93322710
97telomere maintenance via semi-conservative replication (GO:0032201)2.93319101
98high-density lipoprotein particle remodeling (GO:0034375)2.92380236
99cotranslational protein targeting to membrane (GO:0006613)2.91521667
100translational elongation (GO:0006414)2.90519611
101protein targeting to ER (GO:0045047)2.90192157
102peptidyl-arginine N-methylation (GO:0035246)2.88796065
103peptidyl-arginine methylation (GO:0018216)2.88796065
104ethanol oxidation (GO:0006069)2.88246038
105pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.87620949
106DNA geometric change (GO:0032392)2.86762231
107negative regulation of mRNA processing (GO:0050686)2.86597139
108positive regulation of chromosome segregation (GO:0051984)2.86476982
109fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.85599190
110NADPH regeneration (GO:0006740)2.85536001
111aromatic amino acid family metabolic process (GO:0009072)2.85048142
112maturation of SSU-rRNA (GO:0030490)2.84923552
113pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.82844449
114UMP metabolic process (GO:0046049)2.82844449
115pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.82844449
116UMP biosynthetic process (GO:0006222)2.82844449
117purine nucleobase biosynthetic process (GO:0009113)2.81661315
118cellular modified amino acid catabolic process (GO:0042219)2.80424549
119establishment of protein localization to endoplasmic reticulum (GO:0072599)2.78990060
120nuclear pore organization (GO:0006999)2.77912465
121nucleoside salvage (GO:0043174)2.77415398
122DNA conformation change (GO:0071103)2.77091775
123rRNA transcription (GO:0009303)2.77091522
124metaphase plate congression (GO:0051310)2.77016782
125regulation of complement activation (GO:0030449)2.76482942
126protein maturation by protein folding (GO:0022417)2.76400456
127negative regulation of fatty acid biosynthetic process (GO:0045717)2.76148934
128nucleosome disassembly (GO:0006337)2.76094110
129protein-DNA complex disassembly (GO:0032986)2.76094110
130telomere maintenance via telomere lengthening (GO:0010833)2.75644403
131regulation of cholesterol homeostasis (GO:2000188)2.75427775
132nucleotide-excision repair, DNA gap filling (GO:0006297)2.74987860
133regulation of mitotic spindle organization (GO:0060236)2.74672654
1342-oxoglutarate metabolic process (GO:0006103)2.74180106
135pentose-phosphate shunt (GO:0006098)2.74082248
136* alpha-amino acid biosynthetic process (GO:1901607)2.73878623
137membrane disassembly (GO:0030397)2.72911708
138nuclear envelope disassembly (GO:0051081)2.72911708
139viral life cycle (GO:0019058)2.71822396
140complement activation, alternative pathway (GO:0006957)2.71648151
141regulation of spindle organization (GO:0090224)2.70474646
142protein localization to endoplasmic reticulum (GO:0070972)2.70351575
143nuclear envelope organization (GO:0006998)2.70183974
144proline biosynthetic process (GO:0006561)2.69129684
145cellular amino acid catabolic process (GO:0009063)2.68749618
146translational initiation (GO:0006413)2.67662412
147positive regulation of DNA-dependent DNA replication (GO:2000105)2.65937989
148regulation of sister chromatid cohesion (GO:0007063)2.65883288
149nuclear pore complex assembly (GO:0051292)2.65878054
150maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.65872433
151negative regulation of mRNA metabolic process (GO:1903312)2.65595373
152viral mRNA export from host cell nucleus (GO:0046784)2.64598410
153aldehyde catabolic process (GO:0046185)2.64534125
154protein export from nucleus (GO:0006611)2.64060165
155oxaloacetate metabolic process (GO:0006107)2.62789804
156dicarboxylic acid biosynthetic process (GO:0043650)2.62136979
157urate metabolic process (GO:0046415)2.60838063
158valine metabolic process (GO:0006573)2.60272414
159bile acid metabolic process (GO:0008206)2.60101569
160glutamate metabolic process (GO:0006536)2.59847495
161pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.59361691
162aspartate family amino acid catabolic process (GO:0009068)2.58480400
163nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.58448407
164proline metabolic process (GO:0006560)2.58401722
165ribosomal small subunit biogenesis (GO:0042274)2.54498186
166regulation of translational termination (GO:0006449)2.54385297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.00142084
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.52989360
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72093173
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.51193309
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.24070089
6* RXR_22158963_ChIP-Seq_LIVER_Mouse2.85916033
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.78476477
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55376621
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40257899
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38732578
11MYC_22102868_ChIP-Seq_BL_Human2.35511970
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.34727568
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.26594426
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24223966
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.19517209
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17237934
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.13314186
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.06962094
19XRN2_22483619_ChIP-Seq_HELA_Human1.94580676
20AR_21909140_ChIP-Seq_LNCAP_Human1.90183925
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.89499818
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85830325
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.82470014
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78693670
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77058653
26* EST1_17652178_ChIP-ChIP_JURKAT_Human1.76682051
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69424688
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63921772
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.63616873
30VDR_21846776_ChIP-Seq_THP-1_Human1.56451736
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54292188
32* E2F1_21310950_ChIP-Seq_MCF-7_Human1.53935700
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53123897
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.52130665
35DCP1A_22483619_ChIP-Seq_HELA_Human1.50857778
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50691114
37FOXP3_21729870_ChIP-Seq_TREG_Human1.49273054
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48484213
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47460251
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47386037
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46815714
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42775041
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41759413
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41077799
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39599703
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38054697
47CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37287598
48VDR_23849224_ChIP-Seq_CD4+_Human1.36981478
49GABP_19822575_ChIP-Seq_HepG2_Human1.36622862
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33455370
51KDM5A_27292631_Chip-Seq_BREAST_Human1.32591471
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31702396
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30977266
54* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30031398
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.29887135
56CIITA_25753668_ChIP-Seq_RAJI_Human1.27034292
57FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25603154
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25552883
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24128330
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23622569
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23561482
62TTF2_22483619_ChIP-Seq_HELA_Human1.20489867
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19436004
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18959886
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17966102
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17499153
67* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17250325
68RACK7_27058665_Chip-Seq_MCF-7_Human1.16809104
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14706581
70ZNF263_19887448_ChIP-Seq_K562_Human1.13562042
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12604335
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11860800
73SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11391877
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11145625
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11093261
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10716524
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08487639
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06651751
79* LXR_22292898_ChIP-Seq_THP-1_Human1.06618829
80CLOCK_20551151_ChIP-Seq_293T_Human1.04958824
81* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04583005
82CHD1_26751641_Chip-Seq_LNCaP_Human1.04297451
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03897655
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03550617
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02308747
86TFEB_21752829_ChIP-Seq_HELA_Human1.02001979
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00654157
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00160011
89* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00154701
90ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99460253
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99311277
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99160530
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.98467718
94UTX_26944678_Chip-Seq_JUKART_Human0.98210549
95TET1_21451524_ChIP-Seq_MESCs_Mouse0.97611904
96MAF_26560356_Chip-Seq_TH1_Human0.97129922
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96899551
98* ATF3_27146783_Chip-Seq_COLON_Human0.95041562
99HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95023451
100* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93894832
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93545259
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93206192
103ELK3_25401928_ChIP-Seq_HUVEC_Human0.92700886
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92505348
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92387893
106SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91490313
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91406827
108* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90622947
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90079248
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89283945
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89151877
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88157672
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86826679
114TCF7_22412390_ChIP-Seq_EML_Mouse0.85880205
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85409793
116SRF_21415370_ChIP-Seq_HL-1_Mouse0.83572377
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82571652
118MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82542501
119ELK1_19687146_ChIP-ChIP_HELA_Human0.81521992
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81344223
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80872422
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80765579
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80438602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.18429304
2MP0005360_urolithiasis5.03031687
3MP0003806_abnormal_nucleotide_metabolis4.11358132
4MP0005085_abnormal_gallbladder_physiolo3.66650485
5MP0005365_abnormal_bile_salt3.51903940
6MP0008875_abnormal_xenobiotic_pharmacok2.76971697
7MP0003693_abnormal_embryo_hatching2.53492923
8MP0003705_abnormal_hypodermis_morpholog2.48962576
9MP0009840_abnormal_foam_cell2.48289346
10MP0003252_abnormal_bile_duct2.30587766
11MP0004957_abnormal_blastocyst_morpholog2.29929095
12MP0002877_abnormal_melanocyte_morpholog2.24557767
13MP0010094_abnormal_chromosome_stability2.24024403
14MP0004233_abnormal_muscle_weight2.23736610
15MP0003111_abnormal_nucleus_morphology2.22410211
16MP0005083_abnormal_biliary_tract2.10847113
17MP0000537_abnormal_urethra_morphology2.00877567
18MP0003077_abnormal_cell_cycle1.96434912
19MP0010329_abnormal_lipoprotein_level1.94003898
20MP0010352_gastrointestinal_tract_polyps1.89432922
21MP0005332_abnormal_amino_acid1.83437814
22MP0002396_abnormal_hematopoietic_system1.79323344
23MP0004185_abnormal_adipocyte_glucose1.77017884
24MP0008057_abnormal_DNA_replication1.67508952
25MP0003941_abnormal_skin_development1.63100470
26MP0000609_abnormal_liver_physiology1.62595876
27MP0010234_abnormal_vibrissa_follicle1.58950755
28MP0004272_abnormal_basement_membrane1.54902516
29MP0001730_embryonic_growth_arrest1.47805569
30MP0003186_abnormal_redox_activity1.45437275
31MP0001666_abnormal_nutrient_absorption1.44155979
32MP0004858_abnormal_nervous_system1.43757506
33MP0005319_abnormal_enzyme/_coenzyme1.41709554
34MP0001346_abnormal_lacrimal_gland1.40760213
35MP0001661_extended_life_span1.40290142
36MP0003315_abnormal_perineum_morphology1.39744900
37MP0001849_ear_inflammation1.39200287
38MP0010307_abnormal_tumor_latency1.38568953
39MP0003656_abnormal_erythrocyte_physiolo1.37576078
40MP0008007_abnormal_cellular_replicative1.35965852
41MP0000598_abnormal_liver_morphology1.35174335
42MP0000678_abnormal_parathyroid_gland1.32336361
43MP0005257_abnormal_intraocular_pressure1.29997252
44MP0000566_synostosis1.29410544
45MP0002796_impaired_skin_barrier1.28132927
46MP0002697_abnormal_eye_size1.27969809
47MP0003191_abnormal_cellular_cholesterol1.27486456
48MP0000350_abnormal_cell_proliferation1.22123228
49MP0005023_abnormal_wound_healing1.19910228
50MP0009053_abnormal_anal_canal1.18240874
51MP0005623_abnormal_meninges_morphology1.17428293
52MP0002138_abnormal_hepatobiliary_system1.14412991
53MP0008932_abnormal_embryonic_tissue1.14323563
54MP0001764_abnormal_homeostasis1.12865042
55MP0004019_abnormal_vitamin_homeostasis1.10529727
56MP0008058_abnormal_DNA_repair1.09750433
57MP0009643_abnormal_urine_homeostasis1.05490474
58MP0002019_abnormal_tumor_incidence1.05100631
59MP0004808_abnormal_hematopoietic_stem1.03944877
60MP0003195_calcinosis1.03305179
61MP0005380_embryogenesis_phenotype1.02953723
62MP0001672_abnormal_embryogenesis/_devel1.02953723
63MP0002080_prenatal_lethality1.02068638
64MP0004197_abnormal_fetal_growth/weight/1.00055715
65MP0005621_abnormal_cell_physiology0.99605889
66MP0001697_abnormal_embryo_size0.99337136
67MP0000490_abnormal_crypts_of0.99309616
68MP0003984_embryonic_growth_retardation0.98995034
69MP0002088_abnormal_embryonic_growth/wei0.98712470
70MP0002249_abnormal_larynx_morphology0.97681300
71MP0005076_abnormal_cell_differentiation0.96713147
72MP0002118_abnormal_lipid_homeostasis0.95757275
73MP0005384_cellular_phenotype0.95184981
74MP0002089_abnormal_postnatal_growth/wei0.95081072
75MP0003436_decreased_susceptibility_to0.94773037
76MP0002111_abnormal_tail_morphology0.94734530
77MP0002086_abnormal_extraembryonic_tissu0.94387505
78MP0006035_abnormal_mitochondrial_morpho0.94034452
79MP0003453_abnormal_keratinocyte_physiol0.93673966
80MP0009672_abnormal_birth_weight0.93429851
81MP0003868_abnormal_feces_composition0.93428440
82MP0003942_abnormal_urinary_system0.93249754
83MP0009333_abnormal_splenocyte_physiolog0.92528908
84MP0003566_abnormal_cell_adhesion0.92324899
85MP0000689_abnormal_spleen_morphology0.92059129
86MP0001915_intracranial_hemorrhage0.91788549
87MP0005220_abnormal_exocrine_pancreas0.91474345
88MP0003937_abnormal_limbs/digits/tail_de0.90974318
89MP0001545_abnormal_hematopoietic_system0.90671185
90MP0005397_hematopoietic_system_phenotyp0.90671185
91MP0005584_abnormal_enzyme/coenzyme_acti0.90095658
92MP0002722_abnormal_immune_system0.89433024
93MP0000733_abnormal_muscle_development0.88676047
94MP0003763_abnormal_thymus_physiology0.88453134
95MP0000762_abnormal_tongue_morphology0.88391970
96MP0003115_abnormal_respiratory_system0.87762683
97MP0008260_abnormal_autophagy0.87659381
98MP0000003_abnormal_adipose_tissue0.87633896
99MP0005408_hypopigmentation0.87163580
100MP0002092_abnormal_eye_morphology0.87049385
101MP0009763_increased_sensitivity_to0.85661106
102MP0002254_reproductive_system_inflammat0.84194199
103MP0006036_abnormal_mitochondrial_physio0.83282715
104MP0001243_abnormal_dermal_layer0.83212890
105MP0003300_gastrointestinal_ulcer0.82173073
106MP0001348_abnormal_lacrimal_gland0.80648247
107MP0000685_abnormal_immune_system0.79604207
108MP0005464_abnormal_platelet_physiology0.79310228
109MP0002398_abnormal_bone_marrow0.78964396
110MP0000703_abnormal_thymus_morphology0.78897945
111MP0003123_paternal_imprinting0.78689635
112MP0003718_maternal_effect0.78358892
113MP0001853_heart_inflammation0.77734148
114MP0003385_abnormal_body_wall0.77622137
115MP0006054_spinal_hemorrhage0.77403811
116MP0001881_abnormal_mammary_gland0.76922968
117MP0000313_abnormal_cell_death0.75929645
118MP0005266_abnormal_metabolism0.75500971
119MP0003786_premature_aging0.75103924
120MP0000467_abnormal_esophagus_morphology0.74600798
121MP0009703_decreased_birth_body0.74310995
122MP0008469_abnormal_protein_level0.74039049
123MP0005451_abnormal_body_composition0.73928537
124MP0003567_abnormal_fetal_cardiomyocyte0.73858013
125MP0001286_abnormal_eye_development0.73824868
126MP0003221_abnormal_cardiomyocyte_apopto0.73468117
127MP0001216_abnormal_epidermal_layer0.72312720
128MP0002085_abnormal_embryonic_tissue0.71748032
129MP0005666_abnormal_adipose_tissue0.70687613
130MP0009697_abnormal_copulation0.70194895
131MP0000858_altered_metastatic_potential0.69957666
132MP0000377_abnormal_hair_follicle0.69680343
133MP0002084_abnormal_developmental_patter0.69591013
134MP0001293_anophthalmia0.69350128
135MP0002429_abnormal_blood_cell0.67754807
136MP0002970_abnormal_white_adipose0.67525252
137MP0000428_abnormal_craniofacial_morphol0.67098552
138MP0008438_abnormal_cutaneous_collagen0.66540950
139MP0000747_muscle_weakness0.66479507
140MP0000627_abnormal_mammary_gland0.65647314
141MP0000358_abnormal_cell_content/0.64551318
142MP0005501_abnormal_skin_physiology0.64159804
143MP0010030_abnormal_orbit_morphology0.63975078
144MP0008873_increased_physiological_sensi0.63909174
145MP0001800_abnormal_humoral_immune0.63188586
146MP0009931_abnormal_skin_appearance0.62877889
147MP0005636_abnormal_mineral_homeostasis0.61636633
148MP0003303_peritoneal_inflammation0.59843730
149MP0002132_abnormal_respiratory_system0.59706136
150MP0005376_homeostasis/metabolism_phenot0.58718945
151MP0002060_abnormal_skin_morphology0.58133381

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)5.10336121
2Deep venous thrombosis (HP:0002625)4.96855135
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.78309411
4Hypobetalipoproteinemia (HP:0003563)4.65470782
5Intrahepatic cholestasis (HP:0001406)4.65215200
6Abnormality of pyrimidine metabolism (HP:0004353)4.37272669
7Xanthomatosis (HP:0000991)4.18415208
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.74788582
9Abnormality of sulfur amino acid metabolism (HP:0004339)3.55130412
10Hyperammonemia (HP:0001987)3.44406908
11Chromsome breakage (HP:0040012)3.38677848
12Prolonged partial thromboplastin time (HP:0003645)3.33383613
13Spastic diplegia (HP:0001264)3.19333194
14Hypolipoproteinemia (HP:0010981)3.17851632
15Abnormality of methionine metabolism (HP:0010901)3.15683092
16Abnormality of glycolysis (HP:0004366)3.07580528
17Abnormality of aspartate family amino acid metabolism (HP:0010899)3.04370496
18Hyperacusis (HP:0010780)3.02866485
19Hyperglycinemia (HP:0002154)3.02300997
20Abnormality of glycine metabolism (HP:0010895)2.97621900
21Abnormality of serine family amino acid metabolism (HP:0010894)2.97621900
22Abnormality of glutamine family amino acid metabolism (HP:0010902)2.96146808
23Hyperlipoproteinemia (HP:0010980)2.83965510
24Reticulocytopenia (HP:0001896)2.83111608
25Ketosis (HP:0001946)2.79770055
26Abnormality of the common coagulation pathway (HP:0010990)2.78689302
27Microvesicular hepatic steatosis (HP:0001414)2.77349579
28Complement deficiency (HP:0004431)2.76954575
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.74787948
30Increased nuchal translucency (HP:0010880)2.74499694
31Hyperglycinuria (HP:0003108)2.73503282
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.72943815
33Premature rupture of membranes (HP:0001788)2.72591792
34Progressive muscle weakness (HP:0003323)2.71975908
35Joint hemorrhage (HP:0005261)2.68868875
36Abnormality of nucleobase metabolism (HP:0010932)2.67600176
37Trismus (HP:0000211)2.58362370
38Hyperbilirubinemia (HP:0002904)2.54036165
39Cortical dysplasia (HP:0002539)2.53234757
40Abnormality of complement system (HP:0005339)2.53188651
41Abnormality of serum amino acid levels (HP:0003112)2.50286053
42Hepatocellular carcinoma (HP:0001402)2.48376553
43Abnormality of reticulocytes (HP:0004312)2.46667209
44Epidermoid cyst (HP:0200040)2.46655556
45Abnormality of the umbilical cord (HP:0010881)2.46256981
46Fat malabsorption (HP:0002630)2.44425414
47Hypoglycemic coma (HP:0001325)2.43252420
48Hypoalphalipoproteinemia (HP:0003233)2.42015316
49Increased serum pyruvate (HP:0003542)2.37137328
50Abnormality of the intrinsic pathway (HP:0010989)2.35739602
51Deviation of the thumb (HP:0009603)2.35459964
52Proximal placement of thumb (HP:0009623)2.34915338
53Protrusio acetabuli (HP:0003179)2.34736531
54Multiple enchondromatosis (HP:0005701)2.34081110
55Oral leukoplakia (HP:0002745)2.32009069
56Upper limb muscle weakness (HP:0003484)2.31163551
57Insomnia (HP:0100785)2.31112555
58Breast hypoplasia (HP:0003187)2.30218270
59Delayed CNS myelination (HP:0002188)2.29798633
60Pterygium (HP:0001059)2.29522378
61Squamous cell carcinoma (HP:0002860)2.28356742
62Abnormality of cells of the erythroid lineage (HP:0012130)2.27215399
63Reticulocytosis (HP:0001923)2.26167234
64Abnormal cartilage morphology (HP:0002763)2.26135191
65Long palpebral fissure (HP:0000637)2.22694617
66Macrocytic anemia (HP:0001972)2.21686706
67Thrombocytosis (HP:0001894)2.21513549
68Myocardial infarction (HP:0001658)2.20932549
69Increased mean platelet volume (HP:0011877)2.20760983
70Abnormal number of erythroid precursors (HP:0012131)2.18506918
71Overlapping toe (HP:0001845)2.16677670
72Abnormal platelet volume (HP:0011876)2.15917339
73Abnormality of fatty-acid metabolism (HP:0004359)2.13914904
74Late onset (HP:0003584)2.12781676
75Abnormality of iron homeostasis (HP:0011031)2.12396777
76Poikilocytosis (HP:0004447)2.11449172
77Abnormality of the calcaneus (HP:0008364)2.10908453
78Premature skin wrinkling (HP:0100678)2.08526729
79Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07528376
80Rhabdomyosarcoma (HP:0002859)2.07504382
81Ulnar bowing (HP:0003031)2.06879555
82Back pain (HP:0003418)2.05372491
83Abnormality of the Achilles tendon (HP:0005109)2.05151580
84Pseudobulbar signs (HP:0002200)2.05103650
85Vertebral compression fractures (HP:0002953)2.03788744
86Hypercholesterolemia (HP:0003124)2.03514009
87Progressive external ophthalmoplegia (HP:0000590)2.02960305
88Abnormalities of placenta or umbilical cord (HP:0001194)2.01128394
89Increased serum ferritin (HP:0003281)2.00718623
90Megaloblastic anemia (HP:0001889)2.00660905
91Calcaneovalgus deformity (HP:0001848)2.00120259
92Selective tooth agenesis (HP:0001592)2.00046562
93Acanthocytosis (HP:0001927)1.99001373
94Asymmetry of the thorax (HP:0001555)1.98824022
95Abnormality of the preputium (HP:0100587)1.98402400
96Septate vagina (HP:0001153)1.98272842
97Abnormality of transition element cation homeostasis (HP:0011030)1.97760692
98Hypochromic microcytic anemia (HP:0004840)1.97550117
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96827516
100Overriding aorta (HP:0002623)1.95189263
101Achilles tendon contracture (HP:0001771)1.94061865
102Duplication of thumb phalanx (HP:0009942)1.92348585
103Entropion (HP:0000621)1.92067676
104Malnutrition (HP:0004395)1.90354825
105Rough bone trabeculation (HP:0100670)1.90336677
106Renal duplication (HP:0000075)1.90213943
107Hypochromic anemia (HP:0001931)1.89742538
108Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89490967
109Dicarboxylic aciduria (HP:0003215)1.89490967
110Cholelithiasis (HP:0001081)1.89295678
111Broad distal phalanx of finger (HP:0009836)1.87752940
112High anterior hairline (HP:0009890)1.87682886
113Neonatal onset (HP:0003623)1.87432118
114Horseshoe kidney (HP:0000085)1.86247815
115Steatorrhea (HP:0002570)1.85891417
116Ependymoma (HP:0002888)1.84008333
117Abnormality of purine metabolism (HP:0004352)1.82763929
118Poikiloderma (HP:0001029)1.82081823
119Gout (HP:0001997)1.79233452
120Disproportionate tall stature (HP:0001519)1.79214210
121Meckel diverticulum (HP:0002245)1.78273263
122Breech presentation (HP:0001623)1.76533764
123Cholecystitis (HP:0001082)1.76131949
124Abnormal gallbladder physiology (HP:0012438)1.76131949
125Biconcave vertebral bodies (HP:0004586)1.76078814
126Thrombophlebitis (HP:0004418)1.74176394
127Abnormal gallbladder morphology (HP:0012437)1.73808571
128Basal cell carcinoma (HP:0002671)1.73683262
129Abnormal number of incisors (HP:0011064)1.73657931
130Metabolic acidosis (HP:0001942)1.73639830
131Ketoacidosis (HP:0001993)1.72993450
132Ragged-red muscle fibers (HP:0003200)1.72215646
133Secondary amenorrhea (HP:0000869)1.71396568
134Birth length less than 3rd percentile (HP:0003561)1.71195320
135Abnormality of the heme biosynthetic pathway (HP:0010472)1.70970416
136Abnormal platelet function (HP:0011869)1.70760104
137Impaired platelet aggregation (HP:0003540)1.70760104
138Deformed tarsal bones (HP:0008119)1.70526446
139Abnormal umbilical cord blood vessels (HP:0011403)1.70175691
140Single umbilical artery (HP:0001195)1.70175691
141Abnormality of the fetal cardiovascular system (HP:0010948)1.70175691
142Lethargy (HP:0001254)1.69810957
143Pallor (HP:0000980)1.69803253
144Peritonitis (HP:0002586)1.69214779
145Sparse lateral eyebrow (HP:0005338)1.68618808
146Nonimmune hydrops fetalis (HP:0001790)1.67348263
147Elfin facies (HP:0004428)1.66588325
148Microglossia (HP:0000171)1.66301710
149Missing ribs (HP:0000921)1.66155733
150Gingival bleeding (HP:0000225)1.65679360
151Atresia of the external auditory canal (HP:0000413)1.64461183
152Myelodysplasia (HP:0002863)1.64091696
153Abnormality of the ileum (HP:0001549)1.63451078
154Opisthotonus (HP:0002179)1.62667958
155Esophageal varix (HP:0002040)1.59718014
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59325627
157Absent epiphyses (HP:0010577)1.59325627
158Elbow flexion contracture (HP:0002987)1.59260233
15911 pairs of ribs (HP:0000878)1.59179422
160Vascular calcification (HP:0004934)1.58531621
161Abnormality of the carotid arteries (HP:0005344)1.58292176
162Deep palmar crease (HP:0006191)1.57956435
163Small epiphyses (HP:0010585)1.57881504
164Menorrhagia (HP:0000132)1.57624594
165Increased density of long bones (HP:0006392)1.57570263
166Premature ovarian failure (HP:0008209)1.57313222
167Testicular atrophy (HP:0000029)1.56438908
168Abnormal enzyme/coenzyme activity (HP:0012379)1.56356343
169Neoplasm of striated muscle (HP:0009728)1.55108239
170Absent radius (HP:0003974)1.55057151
171Cafe-au-lait spot (HP:0000957)1.54499374
172Distal upper limb amyotrophy (HP:0007149)1.54298448
173Upper limb amyotrophy (HP:0009129)1.54298448
174Unilateral renal agenesis (HP:0000122)1.52635915
175Nephroblastoma (Wilms tumor) (HP:0002667)1.52343208
176Abnormality of the gallbladder (HP:0005264)1.52233139
177Glossoptosis (HP:0000162)1.50779707
178Abnormal trabecular bone morphology (HP:0100671)1.49533091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.15886647
2EEF2K3.58696504
3PKN23.36358689
4VRK23.20272054
5TRIB33.03512141
6CDC72.83736916
7BCKDK2.77238709
8ERN12.53158461
9BUB12.49866672
10WEE12.42192808
11MAP3K102.37424462
12EIF2AK12.26146744
13IRAK32.08613078
14NME22.07615356
15NEK21.98947021
16NEK11.97893993
17FLT31.94477290
18TESK21.91965679
19MAP4K11.91197164
20TAF11.78586291
21CDK121.77774839
22STK101.77524755
23RPS6KB21.67652849
24MAP2K31.64660495
25PBK1.55849480
26SIK11.55665766
27LRRK21.51411069
28CDK41.50055421
29TTK1.48982564
30MAP3K81.48880033
31CDK81.48401449
32RPS6KA41.45511662
33PRPF4B1.43951607
34CDK71.42147195
35FGFR41.36316145
36SCYL21.35670015
37PASK1.29845347
38TLK11.28215094
39MAP3K111.26670451
40TGFBR11.24716459
41ACVR1B1.22696125
42PIM21.11846366
43KDR1.11130971
44PAK41.10263507
45AURKB1.10201587
46TSSK61.07933731
47MST1R1.07852712
48MAPK111.06085989
49GRK61.05509925
50PRKD31.05361516
51CDK61.04859338
52PLK11.04680658
53PIM11.03589335
54ATR1.03209271
55ZAP701.01233109
56BRSK20.97656595
57PTK60.96746248
58EIF2AK30.96458166
59PLK30.94977451
60MAPKAPK30.94177403
61STK40.93442857
62NME10.89297534
63MAP3K30.85110944
64LMTK20.83823769
65MTOR0.83715080
66NEK90.83508297
67BRAF0.83312868
68AURKA0.81864556
69TTN0.81453666
70BTK0.80944536
71ARAF0.80924881
72ALK0.80722997
73CHEK10.80325333
74STK160.76595910
75EPHA20.75595367
76PAK20.72821471
77DYRK30.72225816
78JAK30.72219016
79SRPK10.71972089
80BMX0.71351238
81CAMK1D0.70541158
82TYK20.68984071
83CDK90.66600244
84MOS0.65058377
85BRD40.62826726
86CLK10.59684780
87MET0.59542025
88TAOK20.59061609
89CHEK20.58167991
90BRSK10.57099667
91CDK20.56560312
92ZAK0.56369699
93CSF1R0.55721629
94CDK10.55220390
95LATS10.54755585
96TAOK30.54200642
97AKT20.53821771
98STK30.53397961
99EIF2AK20.53357173
100TBK10.53068029
101IRAK20.52470487
102MAP3K90.51826554
103ATM0.51630500
104MELK0.51411808
105CSNK2A20.50532948
106ERBB40.49632499
107PTK20.48637553
108MKNK10.48333383
109TESK10.48184781
110CDK11A0.47676029
111DAPK10.47497404
112PAK10.45495054
113ICK0.45095950
114CHUK0.44745300
115LATS20.44017216
116TAOK10.43840655
117CDK150.42897079
118PRKCI0.42458876
119VRK10.41660261
120CAMK1G0.41175773
121PIK3CG0.40157168
122CDK180.39967986
123MAPK40.38933708
124DAPK30.38823494
125ILK0.38809403
126CSNK2A10.38661618
127BLK0.37610112
128DYRK1B0.36996351
129ABL20.36779913
130NTRK10.35480868
131CSK0.34876138
132KIT0.34585234
133PDGFRA0.33976732
134PLK40.31839775
135RPS6KA60.31767482

Predicted pathways (KEGG)

RankGene SetZ-score
1* One carbon pool by folate_Homo sapiens_hsa006702.96157634
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93822546
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.92757906
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.76326516
5DNA replication_Homo sapiens_hsa030302.70580466
6* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33450198
7Nitrogen metabolism_Homo sapiens_hsa009102.28573156
8Arginine biosynthesis_Homo sapiens_hsa002202.20133216
9* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16252636
10Selenocompound metabolism_Homo sapiens_hsa004502.14613773
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98345421
12Mismatch repair_Homo sapiens_hsa034301.97696639
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.93391392
14* Biosynthesis of amino acids_Homo sapiens_hsa012301.93048161
15Tryptophan metabolism_Homo sapiens_hsa003801.87706101
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85282047
17Fatty acid degradation_Homo sapiens_hsa000711.75625346
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.74588008
19Ribosome_Homo sapiens_hsa030101.74554163
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.71343302
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66389692
22Complement and coagulation cascades_Homo sapiens_hsa046101.61436622
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61123167
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56304972
25Sulfur relay system_Homo sapiens_hsa041221.54848482
26* Carbon metabolism_Homo sapiens_hsa012001.51856668
27Base excision repair_Homo sapiens_hsa034101.49444451
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48846394
29Folate biosynthesis_Homo sapiens_hsa007901.48588333
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37110017
31RNA transport_Homo sapiens_hsa030131.35985653
32Spliceosome_Homo sapiens_hsa030401.33403301
33Peroxisome_Homo sapiens_hsa041461.29491920
34Pyruvate metabolism_Homo sapiens_hsa006201.28435118
35Pentose phosphate pathway_Homo sapiens_hsa000301.27614096
36Propanoate metabolism_Homo sapiens_hsa006401.26259974
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25561925
38Chemical carcinogenesis_Homo sapiens_hsa052041.21467030
39Nucleotide excision repair_Homo sapiens_hsa034201.20078399
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19129437
41Thyroid cancer_Homo sapiens_hsa052161.18808328
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17942182
43Caffeine metabolism_Homo sapiens_hsa002321.17032683
44Butanoate metabolism_Homo sapiens_hsa006501.16129843
45Pyrimidine metabolism_Homo sapiens_hsa002401.15971981
46Lysine degradation_Homo sapiens_hsa003101.13654372
47beta-Alanine metabolism_Homo sapiens_hsa004101.12641792
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11927518
49N-Glycan biosynthesis_Homo sapiens_hsa005101.10693090
50Phenylalanine metabolism_Homo sapiens_hsa003601.07225686
51Fatty acid metabolism_Homo sapiens_hsa012121.06628035
52Cell cycle_Homo sapiens_hsa041101.06516535
53PPAR signaling pathway_Homo sapiens_hsa033201.02110356
54Homologous recombination_Homo sapiens_hsa034401.00060392
55Histidine metabolism_Homo sapiens_hsa003400.98947997
56Retinol metabolism_Homo sapiens_hsa008300.98877218
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98793314
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.97655108
59Arginine and proline metabolism_Homo sapiens_hsa003300.94335827
60Vitamin B6 metabolism_Homo sapiens_hsa007500.92316261
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91895306
62Glutathione metabolism_Homo sapiens_hsa004800.91247474
63Proteasome_Homo sapiens_hsa030500.89959971
64Tyrosine metabolism_Homo sapiens_hsa003500.87273434
65Staphylococcus aureus infection_Homo sapiens_hsa051500.86245338
66Starch and sucrose metabolism_Homo sapiens_hsa005000.83240650
67MicroRNAs in cancer_Homo sapiens_hsa052060.75977553
68Non-small cell lung cancer_Homo sapiens_hsa052230.75860110
69Purine metabolism_Homo sapiens_hsa002300.73356880
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72888355
71RNA polymerase_Homo sapiens_hsa030200.71869785
72Pancreatic cancer_Homo sapiens_hsa052120.70974804
73* Cyanoamino acid metabolism_Homo sapiens_hsa004600.70697906
74Fat digestion and absorption_Homo sapiens_hsa049750.69996939
75Bile secretion_Homo sapiens_hsa049760.69347486
76Non-homologous end-joining_Homo sapiens_hsa034500.66486039
77Prostate cancer_Homo sapiens_hsa052150.65964972
78Systemic lupus erythematosus_Homo sapiens_hsa053220.65330962
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62302058
80p53 signaling pathway_Homo sapiens_hsa041150.62011420
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61713219
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57388591
83HTLV-I infection_Homo sapiens_hsa051660.56828025
84Basal cell carcinoma_Homo sapiens_hsa052170.56237006
85Prion diseases_Homo sapiens_hsa050200.55302579
86Vitamin digestion and absorption_Homo sapiens_hsa049770.55228135
87Basal transcription factors_Homo sapiens_hsa030220.55060801
88RNA degradation_Homo sapiens_hsa030180.54078793
89ABC transporters_Homo sapiens_hsa020100.52021710
90mRNA surveillance pathway_Homo sapiens_hsa030150.51190739
91Endometrial cancer_Homo sapiens_hsa052130.50353534
92Steroid biosynthesis_Homo sapiens_hsa001000.48898888
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48525445
94Fanconi anemia pathway_Homo sapiens_hsa034600.48028946
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47956419
96Colorectal cancer_Homo sapiens_hsa052100.47336534
97Galactose metabolism_Homo sapiens_hsa000520.44042599
98Fructose and mannose metabolism_Homo sapiens_hsa000510.43237212
99Adherens junction_Homo sapiens_hsa045200.42928480
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42513666
101Viral carcinogenesis_Homo sapiens_hsa052030.42260414
102Oocyte meiosis_Homo sapiens_hsa041140.42124980
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42013301
104Bladder cancer_Homo sapiens_hsa052190.41335822
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.40766118
106Notch signaling pathway_Homo sapiens_hsa043300.40681434
107Apoptosis_Homo sapiens_hsa042100.39972240
108Alcoholism_Homo sapiens_hsa050340.39813939
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38636476
110* Metabolic pathways_Homo sapiens_hsa011000.38373434
111AMPK signaling pathway_Homo sapiens_hsa041520.35792759
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35203175
113Glioma_Homo sapiens_hsa052140.35193338
114Hippo signaling pathway_Homo sapiens_hsa043900.35179114
115HIF-1 signaling pathway_Homo sapiens_hsa040660.35025260
116Melanoma_Homo sapiens_hsa052180.34645238
117Antigen processing and presentation_Homo sapiens_hsa046120.34451375
118Insulin signaling pathway_Homo sapiens_hsa049100.33973507
119Sulfur metabolism_Homo sapiens_hsa009200.33483623
120Proteoglycans in cancer_Homo sapiens_hsa052050.33294572
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33167718
122Hepatitis B_Homo sapiens_hsa051610.32625757
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32366362
124Herpes simplex infection_Homo sapiens_hsa051680.31550202
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30954291
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30397359
127Fatty acid elongation_Homo sapiens_hsa000620.30315406
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29658074
129Primary immunodeficiency_Homo sapiens_hsa053400.28002223
130Small cell lung cancer_Homo sapiens_hsa052220.26919740
131Epstein-Barr virus infection_Homo sapiens_hsa051690.26808831
132Huntingtons disease_Homo sapiens_hsa050160.26608407
133Legionellosis_Homo sapiens_hsa051340.26338974
134Acute myeloid leukemia_Homo sapiens_hsa052210.26259362
135Vibrio cholerae infection_Homo sapiens_hsa051100.25981401
136Chronic myeloid leukemia_Homo sapiens_hsa052200.25907582
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.25194936

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