SHISA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.39933402
2locomotory exploration behavior (GO:0035641)6.23022296
3synaptic vesicle maturation (GO:0016188)6.19567607
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.11141277
5vocalization behavior (GO:0071625)5.81762891
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.68795092
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52159798
8regulation of glutamate receptor signaling pathway (GO:1900449)5.35993653
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.22720706
10synaptic vesicle exocytosis (GO:0016079)5.21506324
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.17588486
12regulation of long-term neuronal synaptic plasticity (GO:0048169)5.02107697
13regulation of synapse structural plasticity (GO:0051823)4.98754682
14regulation of neuronal synaptic plasticity (GO:0048168)4.98015627
15glutamate secretion (GO:0014047)4.91652885
16protein localization to synapse (GO:0035418)4.88504429
17regulation of synaptic vesicle exocytosis (GO:2000300)4.85078538
18exploration behavior (GO:0035640)4.82136014
19dendritic spine morphogenesis (GO:0060997)4.58820819
20synaptic transmission, glutamatergic (GO:0035249)4.54854457
21regulation of synaptic vesicle transport (GO:1902803)4.46323207
22neuron cell-cell adhesion (GO:0007158)4.41034303
23glutamate receptor signaling pathway (GO:0007215)4.39130194
24cerebellar granule cell differentiation (GO:0021707)4.38600411
25neurotransmitter-gated ion channel clustering (GO:0072578)4.36119047
26negative regulation of synaptic transmission, GABAergic (GO:0032229)4.34352025
27neurotransmitter secretion (GO:0007269)4.33973216
28layer formation in cerebral cortex (GO:0021819)4.33136853
29L-amino acid import (GO:0043092)4.26753115
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.21874613
31long-term memory (GO:0007616)4.20791417
32regulation of dendritic spine morphogenesis (GO:0061001)4.19394531
33neuron-neuron synaptic transmission (GO:0007270)4.16530392
34neuronal action potential propagation (GO:0019227)4.14378434
35regulation of excitatory postsynaptic membrane potential (GO:0060079)4.12970882
36cell migration in hindbrain (GO:0021535)4.10521140
37positive regulation of membrane potential (GO:0045838)4.04980820
38central nervous system myelination (GO:0022010)4.01862936
39axon ensheathment in central nervous system (GO:0032291)4.01862936
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98389641
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.94653779
42regulation of synaptic plasticity (GO:0048167)3.90911454
43presynaptic membrane assembly (GO:0097105)3.90395629
44regulation of postsynaptic membrane potential (GO:0060078)3.89443585
45positive regulation of synapse maturation (GO:0090129)3.89257268
46regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.86455362
47auditory behavior (GO:0031223)3.84109797
48neuromuscular process controlling balance (GO:0050885)3.80422410
49positive regulation of synaptic transmission, GABAergic (GO:0032230)3.79958398
50gamma-aminobutyric acid transport (GO:0015812)3.79746698
51positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.76128915
52presynaptic membrane organization (GO:0097090)3.75019090
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.74972990
54amino acid import (GO:0043090)3.70301389
55prepulse inhibition (GO:0060134)3.69500515
56potassium ion homeostasis (GO:0055075)3.67564785
57establishment of mitochondrion localization (GO:0051654)3.66969171
58neuron recognition (GO:0008038)3.65786651
59proline transport (GO:0015824)3.62765665
60positive regulation of neurotransmitter secretion (GO:0001956)3.62431032
61transmission of nerve impulse (GO:0019226)3.62206260
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60609830
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.58557634
64positive regulation of neurotransmitter transport (GO:0051590)3.57800698
65cellular potassium ion homeostasis (GO:0030007)3.56878915
66synaptic vesicle endocytosis (GO:0048488)3.53885408
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.52588606
68potassium ion import (GO:0010107)3.52490047
69response to auditory stimulus (GO:0010996)3.51836723
70behavioral fear response (GO:0001662)3.51139448
71behavioral defense response (GO:0002209)3.51139448
72dendritic spine organization (GO:0097061)3.50401656
73long-term synaptic potentiation (GO:0060291)3.49463523
74regulation of voltage-gated calcium channel activity (GO:1901385)3.49452493
75activation of protein kinase A activity (GO:0034199)3.48089101
76neuronal ion channel clustering (GO:0045161)3.47986426
77regulation of dendritic spine development (GO:0060998)3.44660343
78gamma-aminobutyric acid signaling pathway (GO:0007214)3.44265370
79positive regulation of dendritic spine development (GO:0060999)3.43982765
80neurotransmitter transport (GO:0006836)3.43844538
81positive regulation of dendritic spine morphogenesis (GO:0061003)3.43590679
82axonal fasciculation (GO:0007413)3.42178094
83neuromuscular synaptic transmission (GO:0007274)3.40522302
84regulation of neurotransmitter secretion (GO:0046928)3.37826989
85dendrite morphogenesis (GO:0048813)3.37642795
86negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.36654007
87regulation of vesicle fusion (GO:0031338)3.35797598
88learning (GO:0007612)3.34653154
89negative regulation of dendrite morphogenesis (GO:0050774)3.30392084
90membrane depolarization (GO:0051899)3.29552444
91regulation of neurotransmitter levels (GO:0001505)3.25632144
92sodium ion export (GO:0071436)3.22629906
93regulation of female receptivity (GO:0045924)3.22557113
94fear response (GO:0042596)3.21363039
95postsynaptic membrane organization (GO:0001941)3.20901480
96regulation of neurotransmitter transport (GO:0051588)3.18960170
97positive regulation of synaptic transmission (GO:0050806)3.17092348
98membrane hyperpolarization (GO:0060081)3.15495661
99establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.15002293
100mitochondrion transport along microtubule (GO:0047497)3.15002293
101membrane depolarization during action potential (GO:0086010)3.14826213
102visual learning (GO:0008542)3.13654296
103glycine transport (GO:0015816)3.11568091
104regulation of synaptic transmission (GO:0050804)3.11195444
105neuromuscular process (GO:0050905)3.10973352
106synaptic transmission (GO:0007268)3.10155096
107dopamine receptor signaling pathway (GO:0007212)3.09734603
108pyrimidine nucleobase catabolic process (GO:0006208)3.09592203
109response to histamine (GO:0034776)3.09376507
110vesicle transport along microtubule (GO:0047496)3.08640139
111intraspecies interaction between organisms (GO:0051703)3.07771089
112social behavior (GO:0035176)3.07771089
113cell communication by electrical coupling (GO:0010644)3.07076120
114cerebellar Purkinje cell differentiation (GO:0021702)3.06098410
115striatum development (GO:0021756)3.06025656
116adult walking behavior (GO:0007628)3.05723599
117regulation of respiratory system process (GO:0044065)3.05041141
118regulation of glutamate secretion (GO:0014048)3.04917015
119neuromuscular process controlling posture (GO:0050884)3.04190833
120acidic amino acid transport (GO:0015800)3.04174450
121G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.03985523
122chemosensory behavior (GO:0007635)3.02830413
123cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02475564
124regulation of synapse maturation (GO:0090128)3.02315159
125innervation (GO:0060384)3.00712842
126regulation of ARF protein signal transduction (GO:0032012)2.98612051
127cellular sodium ion homeostasis (GO:0006883)2.95315559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.45601682
2GBX2_23144817_ChIP-Seq_PC3_Human3.46249174
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13685840
4RARB_27405468_Chip-Seq_BRAIN_Mouse3.11104840
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09763798
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01326382
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.86925114
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76028259
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76028259
10DROSHA_22980978_ChIP-Seq_HELA_Human2.75819584
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69846437
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63469432
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54953455
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54097076
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.52412884
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47286839
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45011962
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.42015228
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.34490672
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32780515
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.32176867
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.24097022
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.23764915
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22994615
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20975736
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.18894978
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08564001
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00665526
29AR_21572438_ChIP-Seq_LNCaP_Human1.90091455
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84127137
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.79043244
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69710746
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62738159
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56946334
35SMAD4_21799915_ChIP-Seq_A2780_Human1.46877802
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46720654
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45102083
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41417746
39* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39817883
40* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37404266
41TAF15_26573619_Chip-Seq_HEK293_Human1.34882476
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.29843388
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29243781
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.28988878
45ZNF274_21170338_ChIP-Seq_K562_Hela1.28213864
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25211633
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25200643
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25054148
49* KDM2B_26808549_Chip-Seq_K562_Human1.24164997
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24078724
51AR_19668381_ChIP-Seq_PC3_Human1.24031971
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23337657
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20117527
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.19815811
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.18764372
56* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15426453
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15355138
58STAT3_23295773_ChIP-Seq_U87_Human1.14977340
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14863438
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14416883
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14363060
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13840523
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13558081
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12891922
65P300_19829295_ChIP-Seq_ESCs_Human1.11109520
66AR_25329375_ChIP-Seq_VCAP_Human1.10898457
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.07524159
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07474999
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06658196
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05967610
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03674552
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02429903
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02390103
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01379580
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00488130
76SMAD3_21741376_ChIP-Seq_HESCs_Human0.99973215
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99970922
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99891408
79TCF4_23295773_ChIP-Seq_U87_Human0.99536040
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99042606
81TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98904707
82SMAD_19615063_ChIP-ChIP_OVARY_Human0.98364554
83TP53_20018659_ChIP-ChIP_R1E_Mouse0.97786184
84* ARNT_22903824_ChIP-Seq_MCF-7_Human0.97170266
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96934707
86CTCF_27219007_Chip-Seq_Bcells_Human0.96111236
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94211897
88SMAD4_21741376_ChIP-Seq_HESCs_Human0.93626930
89RNF2_27304074_Chip-Seq_NSC_Mouse0.93418076
90* AHR_22903824_ChIP-Seq_MCF-7_Human0.92662301
91TET1_21490601_ChIP-Seq_MESCs_Mouse0.91593075
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.91405417
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91267291
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90904354
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90167077
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.90106051
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89794368
98RXR_22108803_ChIP-Seq_LS180_Human0.88969680
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88807549
100OCT4_19829295_ChIP-Seq_ESCs_Human0.88731850
101* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88232057
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87870241
103RUNX2_22187159_ChIP-Seq_PCA_Human0.87387360
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86989503
105TP53_16413492_ChIP-PET_HCT116_Human0.85951442
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85375953
107PIAS1_25552417_ChIP-Seq_VCAP_Human0.85305729
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84451383
109DPY_21335234_ChIP-Seq_ESCs_Mouse0.82825975
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82311840
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81314177
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81314177
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80755529
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78806800
115KLF4_19829295_ChIP-Seq_ESCs_Human0.77273377
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.77093876
117* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76581560
118SOX9_26525672_Chip-Seq_HEART_Mouse0.74518819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.45513903
2MP0003880_abnormal_central_pattern4.81786026
3MP0003635_abnormal_synaptic_transmissio4.38504203
4MP0002822_catalepsy4.22095104
5MP0004270_analgesia3.78506560
6MP0002063_abnormal_learning/memory/cond3.63129308
7MP0009745_abnormal_behavioral_response3.60116903
8MP0002064_seizures3.17225843
9MP0005423_abnormal_somatic_nervous2.93723985
10MP0002572_abnormal_emotion/affect_behav2.90747496
11MP0001968_abnormal_touch/_nociception2.87297950
12MP0009046_muscle_twitch2.76256344
13MP0001486_abnormal_startle_reflex2.59331543
14MP0002272_abnormal_nervous_system2.48412327
15MP0002734_abnormal_mechanical_nocicepti2.47100039
16MP0001501_abnormal_sleep_pattern2.25799839
17MP0002736_abnormal_nociception_after2.12539401
18MP0001440_abnormal_grooming_behavior2.04094626
19MP0002735_abnormal_chemical_nociception2.03550360
20MP0002733_abnormal_thermal_nociception1.95252912
21MP0009780_abnormal_chondrocyte_physiolo1.93075665
22MP0001970_abnormal_pain_threshold1.90586958
23MP0004811_abnormal_neuron_physiology1.87292304
24MP0000778_abnormal_nervous_system1.84494735
25MP0002557_abnormal_social/conspecific_i1.79668108
26MP0002909_abnormal_adrenal_gland1.79525792
27MP0004858_abnormal_nervous_system1.77273148
28MP0008569_lethality_at_weaning1.76342584
29MP0005646_abnormal_pituitary_gland1.74126759
30MP0005386_behavior/neurological_phenoty1.74101406
31MP0004924_abnormal_behavior1.74101406
32MP0002067_abnormal_sensory_capabilities1.74029676
33MP0002184_abnormal_innervation1.70572746
34MP0003329_amyloid_beta_deposits1.64306988
35MP0003879_abnormal_hair_cell1.61384629
36MP0001529_abnormal_vocalization1.55228283
37MP0003787_abnormal_imprinting1.52810870
38MP0004885_abnormal_endolymph1.52688264
39MP0000955_abnormal_spinal_cord1.51108601
40MP0005645_abnormal_hypothalamus_physiol1.44831906
41MP0001984_abnormal_olfaction1.42569472
42MP0002066_abnormal_motor_capabilities/c1.40438538
43MP0002882_abnormal_neuron_morphology1.38704581
44MP0006276_abnormal_autonomic_nervous1.35583833
45MP0003633_abnormal_nervous_system1.33909061
46MP0003123_paternal_imprinting1.32425835
47MP0000569_abnormal_digit_pigmentation1.21179274
48MP0001188_hyperpigmentation1.18549614
49MP0001905_abnormal_dopamine_level1.16778405
50MP0001502_abnormal_circadian_rhythm1.16490909
51MP0002152_abnormal_brain_morphology1.13783544
52MP0003075_altered_response_to1.12070736
53MP0004147_increased_porphyrin_level1.10290611
54MP0003631_nervous_system_phenotype1.09615314
55MP0008872_abnormal_physiological_respon1.08317137
56MP0008961_abnormal_basal_metabolism1.08263604
57MP0004142_abnormal_muscle_tone1.07488817
58MP0001177_atelectasis1.05150061
59MP0003122_maternal_imprinting1.05136344
60MP0003121_genomic_imprinting1.01964677
61MP0002653_abnormal_ependyma_morphology1.00592064
62MP0002069_abnormal_eating/drinking_beha1.00023902
63MP0008874_decreased_physiological_sensi0.96568601
64MP0005409_darkened_coat_color0.93993306
65MP0003283_abnormal_digestive_organ0.92956648
66MP0001348_abnormal_lacrimal_gland0.91547867
67MP0008877_abnormal_DNA_methylation0.88263253
68MP0004085_abnormal_heartbeat0.87773943
69MP0000751_myopathy0.86101525
70MP0005394_taste/olfaction_phenotype0.85836982
71MP0005499_abnormal_olfactory_system0.85836982
72MP0010386_abnormal_urinary_bladder0.85373921
73MP0002229_neurodegeneration0.82856056
74MP0001986_abnormal_taste_sensitivity0.80276164
75MP0005535_abnormal_body_temperature0.79863953
76MP0005167_abnormal_blood-brain_barrier0.78095503
77MP0000631_abnormal_neuroendocrine_gland0.77224711
78MP0003690_abnormal_glial_cell0.75703771
79MP0003137_abnormal_impulse_conducting0.72779236
80MP0003634_abnormal_glial_cell0.72423921
81MP0001346_abnormal_lacrimal_gland0.69519581
82MP0003632_abnormal_nervous_system0.69314161
83MP0004145_abnormal_muscle_electrophysio0.68722444
84MP0001963_abnormal_hearing_physiology0.67830738
85MP0000920_abnormal_myelination0.66507391
86MP0000604_amyloidosis0.66497432
87MP0004130_abnormal_muscle_cell0.66293493
88MP0010234_abnormal_vibrissa_follicle0.65976457
89MP0000026_abnormal_inner_ear0.65882136
90MP0004742_abnormal_vestibular_system0.65549107
91MP0003172_abnormal_lysosome_physiology0.64466848
92MP0004510_myositis0.64463805
93MP0005551_abnormal_eye_electrophysiolog0.64370919
94MP0002752_abnormal_somatic_nervous0.64287341
95MP0000013_abnormal_adipose_tissue0.63000545
96MP0001664_abnormal_digestion0.62862960
97MP0003861_abnormal_nervous_system0.62638884
98MP0002638_abnormal_pupillary_reflex0.61720459
99MP0003938_abnormal_ear_development0.61620893
100MP0002090_abnormal_vision0.59811439
101MP0001299_abnormal_eye_distance/0.59484037
102MP0001485_abnormal_pinna_reflex0.58839008
103MP0006292_abnormal_olfactory_placode0.56135468
104MP0010769_abnormal_survival0.54864889
105MP0004043_abnormal_pH_regulation0.54837949
106MP0002234_abnormal_pharynx_morphology0.54644831
107MP0002082_postnatal_lethality0.52312713
108MP0010770_preweaning_lethality0.52312713
109MP0001943_abnormal_respiration0.52108855
110MP0010768_mortality/aging0.51503304
111MP0000566_synostosis0.50922364
112MP0004484_altered_response_of0.49988586
113MP0004233_abnormal_muscle_weight0.49437233
114MP0003956_abnormal_body_size0.49253467
115MP0002081_perinatal_lethality0.47541318

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.04316469
2Focal motor seizures (HP:0011153)7.99468320
3Focal seizures (HP:0007359)5.91403554
4Visual hallucinations (HP:0002367)4.96248736
5Epileptic encephalopathy (HP:0200134)4.67434651
6Progressive cerebellar ataxia (HP:0002073)4.09066116
7Febrile seizures (HP:0002373)4.01707312
8Poor eye contact (HP:0000817)3.95334284
9Broad-based gait (HP:0002136)3.87306154
10Absence seizures (HP:0002121)3.81578686
11Generalized tonic-clonic seizures (HP:0002069)3.80073178
12Action tremor (HP:0002345)3.75417984
13Atonic seizures (HP:0010819)3.75351629
14Ankle clonus (HP:0011448)3.69970987
15Supranuclear gaze palsy (HP:0000605)3.68509496
16Impaired vibration sensation in the lower limbs (HP:0002166)3.64173820
17Impaired social interactions (HP:0000735)3.54212993
18Abnormal social behavior (HP:0012433)3.54212993
19Dialeptic seizures (HP:0011146)3.54023994
20Peripheral hypomyelination (HP:0007182)3.47194688
21Papilledema (HP:0001085)3.45794168
22Depression (HP:0000716)3.40195602
23Gaze-evoked nystagmus (HP:0000640)3.24503633
24Urinary bladder sphincter dysfunction (HP:0002839)3.23813029
25Torticollis (HP:0000473)3.19009925
26Postural instability (HP:0002172)3.15418685
27Dysdiadochokinesis (HP:0002075)3.13577570
28Mutism (HP:0002300)3.12241662
29Anxiety (HP:0000739)3.11365249
30Abnormality of the lower motor neuron (HP:0002366)3.11319660
31Dysmetria (HP:0001310)3.10722218
32Hyperventilation (HP:0002883)3.10210362
33Amblyopia (HP:0000646)3.01557706
34Abnormal eating behavior (HP:0100738)2.98296557
35Focal dystonia (HP:0004373)2.96517298
36Urinary urgency (HP:0000012)2.89146727
37Stereotypic behavior (HP:0000733)2.89068558
38Genetic anticipation (HP:0003743)2.88512531
39Drooling (HP:0002307)2.82180830
40Excessive salivation (HP:0003781)2.82180830
41Akinesia (HP:0002304)2.81739656
42Truncal ataxia (HP:0002078)2.80689940
43Cerebral hypomyelination (HP:0006808)2.77430712
44Annular pancreas (HP:0001734)2.77387368
45Impaired smooth pursuit (HP:0007772)2.70456866
46Spastic gait (HP:0002064)2.66986571
47Delusions (HP:0000746)2.65121180
48Craniofacial dystonia (HP:0012179)2.64569674
49Hemiparesis (HP:0001269)2.61537639
50Bradykinesia (HP:0002067)2.55938526
51Pointed chin (HP:0000307)2.55372157
52Spastic tetraparesis (HP:0001285)2.51569439
53Hemiplegia (HP:0002301)2.50147475
54Intention tremor (HP:0002080)2.48947820
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.45577262
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45577262
57Impaired vibratory sensation (HP:0002495)2.42192991
58Cerebral inclusion bodies (HP:0100314)2.40953166
59Megalencephaly (HP:0001355)2.40641269
60Epileptiform EEG discharges (HP:0011182)2.40343127
61Neurofibrillary tangles (HP:0002185)2.37785462
62Abnormality of ocular smooth pursuit (HP:0000617)2.35249676
63Scanning speech (HP:0002168)2.34808093
64Progressive inability to walk (HP:0002505)2.34457961
65Diplopia (HP:0000651)2.34045124
66Abnormality of binocular vision (HP:0011514)2.34045124
67Ankyloglossia (HP:0010296)2.33439411
68Obstructive sleep apnea (HP:0002870)2.29021619
69Absent speech (HP:0001344)2.26441535
70Ventricular fibrillation (HP:0001663)2.26396553
71Lower limb muscle weakness (HP:0007340)2.25861236
72EEG with generalized epileptiform discharges (HP:0011198)2.24370352
73Insomnia (HP:0100785)2.22733522
74Lower limb amyotrophy (HP:0007210)2.22329783
75Limb dystonia (HP:0002451)2.16989041
76Morphological abnormality of the pyramidal tract (HP:0002062)2.16932676
77Status epilepticus (HP:0002133)2.15262719
78Tetraplegia (HP:0002445)2.14695826
79Hypsarrhythmia (HP:0002521)2.13718801
80Polyphagia (HP:0002591)2.13709192
81Diminished motivation (HP:0000745)2.11930950
82Dysmetric saccades (HP:0000641)2.11717728
83Abnormal EKG (HP:0003115)2.11125673
84Fetal akinesia sequence (HP:0001989)2.08335702
85Insidious onset (HP:0003587)2.07701003
86Termporal pattern (HP:0011008)2.07701003
87Abnormality of the corticospinal tract (HP:0002492)2.07586020
88Incomplete penetrance (HP:0003829)2.06977781
89Amyotrophic lateral sclerosis (HP:0007354)2.02939211
90Increased circulating renin level (HP:0000848)2.02755498
91Agitation (HP:0000713)2.02071421
92Clonus (HP:0002169)2.00785741
93Gait imbalance (HP:0002141)1.99459080
94Generalized myoclonic seizures (HP:0002123)1.95634400
95Resting tremor (HP:0002322)1.95588627
96Spastic tetraplegia (HP:0002510)1.94916483
97Hypoplasia of the corpus callosum (HP:0002079)1.94646015
98Inappropriate behavior (HP:0000719)1.93436010
99Gait ataxia (HP:0002066)1.90398846
100Inability to walk (HP:0002540)1.90378620
101Neuronal loss in central nervous system (HP:0002529)1.88395589
102Protruding tongue (HP:0010808)1.86639229
103Abnormality of salivation (HP:0100755)1.85983025
104Lower limb asymmetry (HP:0100559)1.85069023
105Sleep apnea (HP:0010535)1.83668310
106Bundle branch block (HP:0011710)1.82404656
107Split foot (HP:0001839)1.81895206
108CNS hypomyelination (HP:0003429)1.81528045
109Failure to thrive in infancy (HP:0001531)1.81359931
110Apathy (HP:0000741)1.80760127
111Blue irides (HP:0000635)1.80072975
112Rigidity (HP:0002063)1.78785020
113Abnormality of the labia minora (HP:0012880)1.74850810
114Aqueductal stenosis (HP:0002410)1.73645237
115Specific learning disability (HP:0001328)1.73333170
116Autism (HP:0000717)1.72841283
117Abnormality of the periventricular white matter (HP:0002518)1.72186838
118Truncus arteriosus (HP:0001660)1.71802898
119Aplasia involving bones of the extremities (HP:0009825)1.70890620
120Aplasia involving bones of the upper limbs (HP:0009823)1.70890620
121Aplasia of the phalanges of the hand (HP:0009802)1.70890620
122Psychosis (HP:0000709)1.70518190
123Choreoathetosis (HP:0001266)1.67534591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.61313419
2NTRK34.80438937
3MAP3K93.95552042
4MARK13.22710661
5DAPK22.74143320
6MAP3K42.68418519
7MINK12.56764471
8PRKD32.33945671
9KSR22.27649940
10PAK62.19758277
11NTRK22.14333146
12MAP2K72.11751801
13RIPK41.98852413
14KSR11.91796758
15CAMKK11.90030111
16DAPK11.82081374
17MAP2K41.65673402
18SIK21.63203638
19CDK51.62197367
20NTRK11.58730157
21TNIK1.48248837
22PRPF4B1.46526401
23MAP3K121.43419111
24TYRO31.41958469
25FES1.36386633
26STK381.32913890
27TAOK11.28497174
28MAPK131.25858601
29ARAF1.23363705
30MAP3K131.22867420
31PRKCG1.19957437
32CASK1.19938531
33MAP3K21.17759099
34PKN11.15740813
35PLK21.15505707
36CDK191.09424475
37UHMK11.03139400
38GRK51.01859566
39PNCK0.96188416
40CAMK10.95438034
41SGK2230.94672655
42SGK4940.94672655
43CAMK2A0.93205562
44RAF10.93154158
45MARK20.91296301
46CDK180.91270503
47DYRK20.89447613
48STK110.89272506
49CDK150.88254820
50CAMK2B0.86485826
51PINK10.84215544
52SGK20.83805191
53MAPK120.83674688
54EPHB20.82973427
55CDK140.82512553
56PTK2B0.82393720
57PRKCH0.81528379
58PHKG10.80921800
59PHKG20.80921800
60LATS20.80124001
61ALK0.79584168
62SGK10.78263916
63SGK30.77730960
64CDK11A0.76645133
65RET0.73679312
66CAMKK20.73463589
67BMPR20.72841495
68PDK10.66029602
69MAP3K110.65947616
70DYRK1A0.65581537
71PDPK10.63448079
72CAMK1D0.61133706
73PRKCZ0.60223695
74CSNK1G20.59643243
75PAK30.58445022
76MAP3K10.53895090
77LMTK20.52184112
78RPS6KA30.51815406
79CAMK40.50977758
80DMPK0.50453315
81OXSR10.50140118
82MAP3K70.48887328
83WNK30.48579291
84CDC42BPA0.48156655
85TNK20.48112885
86FYN0.47739051
87MAPK100.46514556
88SIK30.46014888
89AKT30.44775709
90CCNB10.44330794
91FGR0.42757860
92BRSK10.42299565
93NEK60.41941539
94PRKCE0.40734951
95NEK10.40562623
96MAP2K10.38470417
97DAPK30.38191095
98CAMK1G0.37944737
99WNK10.37873909
100MAPK80.36718433
101BRAF0.36367367
102NME10.34782959
103BCR0.34522812
104CSNK1D0.34287420
105PRKG10.34105036
106FGFR20.33842618
107PRKCA0.33232249
108CAMK2G0.33223362
109ERBB20.33168833
110RIPK10.33095269
111PRKACA0.33082618
112CAMK2D0.33046616
113PRKCB0.32888021
114RPS6KA20.32887473
115GSK3B0.32470100
116CSNK1E0.31585757
117PRKD20.30881289
118CSNK1G30.29490427
119ROCK20.28081213

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.63309468
2Synaptic vesicle cycle_Homo sapiens_hsa047213.05313552
3Olfactory transduction_Homo sapiens_hsa047403.03185516
4Circadian entrainment_Homo sapiens_hsa047132.82626998
5Long-term potentiation_Homo sapiens_hsa047202.80375760
6Glutamatergic synapse_Homo sapiens_hsa047242.69666661
7Amphetamine addiction_Homo sapiens_hsa050312.65521924
8GABAergic synapse_Homo sapiens_hsa047272.65253959
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58291242
10Morphine addiction_Homo sapiens_hsa050322.55625014
11Dopaminergic synapse_Homo sapiens_hsa047282.28889517
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19787218
13Salivary secretion_Homo sapiens_hsa049702.18253711
14Cholinergic synapse_Homo sapiens_hsa047252.03817461
15Insulin secretion_Homo sapiens_hsa049111.97380544
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91841707
17Cocaine addiction_Homo sapiens_hsa050301.91597357
18Gastric acid secretion_Homo sapiens_hsa049711.89052255
19Oxytocin signaling pathway_Homo sapiens_hsa049211.73144127
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71705584
21Renin secretion_Homo sapiens_hsa049241.69667408
22Calcium signaling pathway_Homo sapiens_hsa040201.66070168
23Long-term depression_Homo sapiens_hsa047301.65864874
24Taste transduction_Homo sapiens_hsa047421.61566569
25Serotonergic synapse_Homo sapiens_hsa047261.60226027
26GnRH signaling pathway_Homo sapiens_hsa049121.51493868
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43506340
28Gap junction_Homo sapiens_hsa045401.42205126
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34750476
30cAMP signaling pathway_Homo sapiens_hsa040241.34748638
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31867867
32Glioma_Homo sapiens_hsa052141.26500443
33Type II diabetes mellitus_Homo sapiens_hsa049301.23217074
34Nitrogen metabolism_Homo sapiens_hsa009101.22407567
35Axon guidance_Homo sapiens_hsa043601.21975142
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13239811
37ErbB signaling pathway_Homo sapiens_hsa040121.12048182
38Estrogen signaling pathway_Homo sapiens_hsa049151.11475021
39Melanogenesis_Homo sapiens_hsa049161.05582378
40Collecting duct acid secretion_Homo sapiens_hsa049661.03603857
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02135147
42Vitamin B6 metabolism_Homo sapiens_hsa007501.00454947
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95747136
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95724712
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94198809
46Oocyte meiosis_Homo sapiens_hsa041140.93972894
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.93272820
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.91139753
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85640107
50Choline metabolism in cancer_Homo sapiens_hsa052310.82830218
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82617954
52Pancreatic secretion_Homo sapiens_hsa049720.82144845
53VEGF signaling pathway_Homo sapiens_hsa043700.80188613
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79683810
55Dorso-ventral axis formation_Homo sapiens_hsa043200.79191109
56MAPK signaling pathway_Homo sapiens_hsa040100.74276908
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.71781080
58Thyroid hormone synthesis_Homo sapiens_hsa049180.71779271
59Cardiac muscle contraction_Homo sapiens_hsa042600.71437597
60Dilated cardiomyopathy_Homo sapiens_hsa054140.71059365
61Phototransduction_Homo sapiens_hsa047440.68221143
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66775187
63Vibrio cholerae infection_Homo sapiens_hsa051100.65919828
64Rap1 signaling pathway_Homo sapiens_hsa040150.65664777
65mTOR signaling pathway_Homo sapiens_hsa041500.62905399
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61843057
67Ras signaling pathway_Homo sapiens_hsa040140.61186006
68Non-small cell lung cancer_Homo sapiens_hsa052230.60916597
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59283270
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59104909
71Alcoholism_Homo sapiens_hsa050340.57837708
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.57020783
73Glucagon signaling pathway_Homo sapiens_hsa049220.55288629
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54648578
75Type I diabetes mellitus_Homo sapiens_hsa049400.52416433
76Endometrial cancer_Homo sapiens_hsa052130.52247537
77Endocytosis_Homo sapiens_hsa041440.52116174
78Bile secretion_Homo sapiens_hsa049760.49017151
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47616048
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45769779
81Prion diseases_Homo sapiens_hsa050200.45202773
82Wnt signaling pathway_Homo sapiens_hsa043100.45042525
83Fatty acid biosynthesis_Homo sapiens_hsa000610.45025803
84Circadian rhythm_Homo sapiens_hsa047100.44720253
85Inositol phosphate metabolism_Homo sapiens_hsa005620.44719155
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44308954
87Renal cell carcinoma_Homo sapiens_hsa052110.44182690
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42223205
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41982382
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41104876
91African trypanosomiasis_Homo sapiens_hsa051430.40171514
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39714653
93Chemokine signaling pathway_Homo sapiens_hsa040620.39499228
94Insulin signaling pathway_Homo sapiens_hsa049100.39379639
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35159351
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34227843
97Ovarian steroidogenesis_Homo sapiens_hsa049130.33519383
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32212991
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31775037
100Alzheimers disease_Homo sapiens_hsa050100.29354160
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28268076
102Colorectal cancer_Homo sapiens_hsa052100.28243848
103Hippo signaling pathway_Homo sapiens_hsa043900.27645026
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26957990
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25370516
106AMPK signaling pathway_Homo sapiens_hsa041520.25192929
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.24504928
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24091678
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24081092
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23645996
111Butanoate metabolism_Homo sapiens_hsa006500.23098625
112Regulation of autophagy_Homo sapiens_hsa041400.20462330

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