SHISA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.44541216
2ionotropic glutamate receptor signaling pathway (GO:0035235)6.34341814
3vocalization behavior (GO:0071625)5.86243878
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.79773835
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.72616369
6glutamate receptor signaling pathway (GO:0007215)5.64956084
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.58902114
8neurofilament cytoskeleton organization (GO:0060052)5.45271577
9synaptic vesicle maturation (GO:0016188)5.41516411
10synaptic transmission, glutamatergic (GO:0035249)5.38587833
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.32438110
12exploration behavior (GO:0035640)5.12771809
13regulation of glutamate receptor signaling pathway (GO:1900449)5.11555207
14synaptic vesicle exocytosis (GO:0016079)5.05180340
15positive regulation of synapse maturation (GO:0090129)4.90269054
16neuronal action potential propagation (GO:0019227)4.78766724
17glutamate secretion (GO:0014047)4.75115327
18cerebellar granule cell differentiation (GO:0021707)4.70710443
19neuron-neuron synaptic transmission (GO:0007270)4.69303221
20response to auditory stimulus (GO:0010996)4.61831532
21protein localization to synapse (GO:0035418)4.60099385
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.55023101
23long-term memory (GO:0007616)4.52621069
24regulation of synaptic vesicle exocytosis (GO:2000300)4.49260280
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.47301203
26regulation of neuronal synaptic plasticity (GO:0048168)4.44705343
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.42343846
28cellular potassium ion homeostasis (GO:0030007)4.36601543
29neuron cell-cell adhesion (GO:0007158)4.31768474
30neurotransmitter secretion (GO:0007269)4.30603676
31regulation of excitatory postsynaptic membrane potential (GO:0060079)4.24676892
32cell migration in hindbrain (GO:0021535)4.21875510
33gamma-aminobutyric acid transport (GO:0015812)4.21179187
34gamma-aminobutyric acid signaling pathway (GO:0007214)4.19474440
35regulation of synaptic vesicle transport (GO:1902803)4.18125428
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17100771
37neurotransmitter-gated ion channel clustering (GO:0072578)4.13244222
38cerebellar Purkinje cell differentiation (GO:0021702)4.09101393
39regulation of synapse structural plasticity (GO:0051823)4.06194190
40potassium ion import (GO:0010107)4.05539959
41auditory behavior (GO:0031223)4.01100188
42regulation of NFAT protein import into nucleus (GO:0051532)3.97939230
43regulation of postsynaptic membrane potential (GO:0060078)3.95855350
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.92558229
45innervation (GO:0060384)3.92472871
46dendritic spine morphogenesis (GO:0060997)3.91379237
47synaptic vesicle endocytosis (GO:0048488)3.90749082
48regulation of synapse maturation (GO:0090128)3.90638981
49sodium ion export (GO:0071436)3.90181263
50central nervous system myelination (GO:0022010)3.89449701
51axon ensheathment in central nervous system (GO:0032291)3.89449701
52layer formation in cerebral cortex (GO:0021819)3.81971808
53regulation of synaptic plasticity (GO:0048167)3.80998032
54response to pheromone (GO:0019236)3.79287732
55positive regulation of membrane potential (GO:0045838)3.79256430
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.78871177
57neuron recognition (GO:0008038)3.76897874
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.76574794
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.73522073
60transmission of nerve impulse (GO:0019226)3.73249890
61dopamine biosynthetic process (GO:0042416)3.72273840
62positive regulation of action potential (GO:0045760)3.68291825
63behavioral defense response (GO:0002209)3.65903620
64behavioral fear response (GO:0001662)3.65903620
65chemosensory behavior (GO:0007635)3.65143265
66long-term synaptic potentiation (GO:0060291)3.65072269
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.62622264
68cell communication by electrical coupling (GO:0010644)3.57632611
69axonal fasciculation (GO:0007413)3.54989759
70regulation of dendritic spine morphogenesis (GO:0061001)3.54627565
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.51369115
72neuronal ion channel clustering (GO:0045161)3.48586373
73neurotransmitter transport (GO:0006836)3.47757234
74behavioral response to nicotine (GO:0035095)3.47373349
75cell differentiation in hindbrain (GO:0021533)3.47024901
76dendritic spine organization (GO:0097061)3.44358821
77fear response (GO:0042596)3.44178913
78negative regulation of dendrite development (GO:2000171)3.42765013
79neuromuscular process controlling balance (GO:0050885)3.41344215
80membrane depolarization (GO:0051899)3.40868022
81pyrimidine nucleobase catabolic process (GO:0006208)3.39797598
82proline transport (GO:0015824)3.38098328
83potassium ion homeostasis (GO:0055075)3.35772615
84dendrite morphogenesis (GO:0048813)3.35060909
85regulation of vesicle fusion (GO:0031338)3.34896561
86regulation of glycogen (starch) synthase activity (GO:2000465)3.34365213
87long term synaptic depression (GO:0060292)3.32865919
88membrane depolarization during action potential (GO:0086010)3.32109685
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.31936858
90postsynaptic membrane organization (GO:0001941)3.30252392
91retina layer formation (GO:0010842)3.30072780
92positive regulation of dendritic spine development (GO:0060999)3.28717149
93regulation of neurotransmitter levels (GO:0001505)3.28568103
94startle response (GO:0001964)3.27843174
95learning (GO:0007612)3.27374849
96regulation of neurotransmitter secretion (GO:0046928)3.26851442
97cerebellar Purkinje cell layer development (GO:0021680)3.24358596
98central nervous system projection neuron axonogenesis (GO:0021952)3.23606696
99C4-dicarboxylate transport (GO:0015740)3.22394087
100negative regulation of dendrite morphogenesis (GO:0050774)3.21017065
101cellular sodium ion homeostasis (GO:0006883)3.20744832
102detection of calcium ion (GO:0005513)3.17047426
103adult walking behavior (GO:0007628)3.17046665
104cochlea development (GO:0090102)3.16980387
105neuromuscular process controlling posture (GO:0050884)3.15664188
106regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.15533019
107mechanosensory behavior (GO:0007638)3.14846556
108cytoplasmic mRNA processing body assembly (GO:0033962)3.14714901
109regulation of synaptic transmission (GO:0050804)3.12368521
110presynaptic membrane organization (GO:0097090)3.11586165
111L-amino acid import (GO:0043092)3.09569965
112response to histamine (GO:0034776)3.07699771
113negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07698385
114serotonin metabolic process (GO:0042428)3.07119859
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04342324
116neuromuscular process (GO:0050905)3.04324561
117synaptic transmission (GO:0007268)3.03889967
118synapse assembly (GO:0007416)3.02314331
119presynaptic membrane assembly (GO:0097105)3.01183879
120positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00167026
121establishment of nucleus localization (GO:0040023)2.99833160
122regulation of neurotransmitter transport (GO:0051588)2.95805703
123regulation of dendritic spine development (GO:0060998)2.95614240
124positive regulation of synapse assembly (GO:0051965)2.95491824
125neuromuscular synaptic transmission (GO:0007274)2.94364404
126regulation of female receptivity (GO:0045924)2.92145650
127membrane hyperpolarization (GO:0060081)2.91999859
128negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87816668
129short-term memory (GO:0007614)2.85806205
130somite rostral/caudal axis specification (GO:0032525)2.85601565
131adult behavior (GO:0030534)2.81182339
132positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80214391
133behavioral response to cocaine (GO:0048148)2.78990522
134positive regulation of potassium ion transmembrane transport (GO:1901381)2.74704857
135response to insecticide (GO:0017085)2.74619262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.44462480
2GBX2_23144817_ChIP-Seq_PC3_Human3.78978716
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.20592484
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.18245745
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16287490
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81350857
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81350857
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.73606672
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71899257
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65606605
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64365665
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53771744
13* DROSHA_22980978_ChIP-Seq_HELA_Human2.51364890
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51194343
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.42921507
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42726917
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.42578896
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.39929310
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.26516546
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.24454703
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.22334238
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19971991
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14275260
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.13886355
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05125165
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95496351
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91723417
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89169979
29* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82349875
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.78449667
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70897919
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70024186
33ZNF274_21170338_ChIP-Seq_K562_Hela1.68811711
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68171050
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66634097
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66464852
37AR_21572438_ChIP-Seq_LNCaP_Human1.64392408
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61087610
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50595913
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48502616
41* P300_19829295_ChIP-Seq_ESCs_Human1.44604740
42TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38606534
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38099976
44AR_25329375_ChIP-Seq_VCAP_Human1.37515369
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.34809252
46IGF1R_20145208_ChIP-Seq_DFB_Human1.31925207
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31605446
48* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31364196
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31230977
50TAF15_26573619_Chip-Seq_HEK293_Human1.30891914
51CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30823134
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.30163293
53* RING1B_27294783_Chip-Seq_ESCs_Mouse1.27530008
54AR_19668381_ChIP-Seq_PC3_Human1.27258409
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.27160875
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.27036902
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.26702233
58STAT3_23295773_ChIP-Seq_U87_Human1.25835404
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25377157
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23715604
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.22939586
62* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21408739
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19666184
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.18875221
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17102973
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15754392
67TP53_16413492_ChIP-PET_HCT116_Human1.15080864
68TCF4_23295773_ChIP-Seq_U87_Human1.13906876
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13377412
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13337395
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13233644
72* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10464892
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.10174636
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09861744
75* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09626456
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.09370962
77* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08349351
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08197489
79CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07191902
80* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06274543
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05215723
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04403574
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04378262
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04378262
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03996699
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03580519
87RNF2_27304074_Chip-Seq_NSC_Mouse1.03381920
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03037020
89FUS_26573619_Chip-Seq_HEK293_Human1.02925019
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.02582664
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01373808
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00374356
93* RUNX2_22187159_ChIP-Seq_PCA_Human1.00180842
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98634125
95RXR_22108803_ChIP-Seq_LS180_Human0.98500508
96EP300_21415370_ChIP-Seq_HL-1_Mouse0.97338366
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96915203
98* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96713607
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.96520944
100AHR_22903824_ChIP-Seq_MCF-7_Human0.96014703
101TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94718128
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94540295
103* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94513540
104TP53_18474530_ChIP-ChIP_U2OS_Human0.94380881
105SMAD4_21741376_ChIP-Seq_EPCs_Human0.94200110
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.94195642
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93944907
108* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92781521
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92612908
110BCAT_22108803_ChIP-Seq_LS180_Human0.92092174
111VDR_22108803_ChIP-Seq_LS180_Human0.91824128
112NANOG_18555785_Chip-Seq_ESCs_Mouse0.91400538
113KDM2B_26808549_Chip-Seq_K562_Human0.91313557
114SOX9_26525672_Chip-Seq_HEART_Mouse0.90040872
115* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89425332
116JUN_21703547_ChIP-Seq_K562_Human0.89386844
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88964640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.46358559
2MP0003880_abnormal_central_pattern4.68256163
3MP0003635_abnormal_synaptic_transmissio4.41237407
4MP0009745_abnormal_behavioral_response3.53525856
5MP0002063_abnormal_learning/memory/cond3.53250426
6MP0004270_analgesia3.47473058
7MP0009046_muscle_twitch3.45688469
8MP0002064_seizures3.22534785
9MP0002572_abnormal_emotion/affect_behav2.93844722
10MP0001968_abnormal_touch/_nociception2.86527269
11MP0002272_abnormal_nervous_system2.79363130
12MP0002735_abnormal_chemical_nociception2.74503691
13MP0005423_abnormal_somatic_nervous2.57720629
14MP0002734_abnormal_mechanical_nocicepti2.52572549
15MP0001501_abnormal_sleep_pattern2.49221776
16MP0001440_abnormal_grooming_behavior2.48192808
17MP0002736_abnormal_nociception_after2.47395883
18MP0001486_abnormal_startle_reflex2.40681363
19MP0003890_abnormal_embryonic-extraembry2.37130013
20MP0008569_lethality_at_weaning2.33527840
21MP0002067_abnormal_sensory_capabilities2.17264711
22MP0002184_abnormal_innervation2.14866888
23MP0000566_synostosis1.98925362
24MP0000778_abnormal_nervous_system1.96500759
25MP0002733_abnormal_thermal_nociception1.84518255
26MP0002557_abnormal_social/conspecific_i1.83425915
27MP0004858_abnormal_nervous_system1.81723372
28MP0001970_abnormal_pain_threshold1.80280073
29MP0003123_paternal_imprinting1.73585620
30MP0003787_abnormal_imprinting1.71938678
31MP0004811_abnormal_neuron_physiology1.69560869
32MP0003329_amyloid_beta_deposits1.68012279
33MP0009780_abnormal_chondrocyte_physiolo1.67499286
34MP0004885_abnormal_endolymph1.66117634
35MP0005386_behavior/neurological_phenoty1.58419746
36MP0004924_abnormal_behavior1.58419746
37MP0003879_abnormal_hair_cell1.58158265
38MP0000955_abnormal_spinal_cord1.58046743
39MP0006276_abnormal_autonomic_nervous1.54979978
40MP0004145_abnormal_muscle_electrophysio1.51203262
41MP0003121_genomic_imprinting1.49540931
42MP0002066_abnormal_motor_capabilities/c1.46490830
43MP0002882_abnormal_neuron_morphology1.42475991
44MP0002909_abnormal_adrenal_gland1.42436601
45MP0005646_abnormal_pituitary_gland1.41332748
46MP0005645_abnormal_hypothalamus_physiol1.41254509
47MP0001188_hyperpigmentation1.36849983
48MP0001984_abnormal_olfaction1.34145756
49MP0003633_abnormal_nervous_system1.31763961
50MP0001502_abnormal_circadian_rhythm1.31492315
51MP0004142_abnormal_muscle_tone1.31196313
52MP0003631_nervous_system_phenotype1.21508917
53MP0002152_abnormal_brain_morphology1.18286953
54MP0004742_abnormal_vestibular_system1.15313290
55MP0003632_abnormal_nervous_system1.08640594
56MP0004510_myositis1.07990096
57MP0006072_abnormal_retinal_apoptosis1.07931915
58MP0003119_abnormal_digestive_system1.03228952
59MP0003011_delayed_dark_adaptation1.02880923
60MP0002822_catalepsy1.00545201
61MP0003122_maternal_imprinting1.00007683
62MP0001905_abnormal_dopamine_level0.97669489
63MP0004484_altered_response_of0.95755789
64MP0004133_heterotaxia0.93530532
65MP0001963_abnormal_hearing_physiology0.93169405
66MP0002069_abnormal_eating/drinking_beha0.92088973
67MP0000569_abnormal_digit_pigmentation0.91444432
68MP0008872_abnormal_physiological_respon0.89347315
69MP0006292_abnormal_olfactory_placode0.87111353
70MP0002229_neurodegeneration0.86909339
71MP0004215_abnormal_myocardial_fiber0.86703541
72MP0001177_atelectasis0.86058146
73MP0005253_abnormal_eye_physiology0.85300051
74MP0005551_abnormal_eye_electrophysiolog0.83543287
75MP0010386_abnormal_urinary_bladder0.83397586
76MP0005499_abnormal_olfactory_system0.81203763
77MP0005394_taste/olfaction_phenotype0.81203763
78MP0003075_altered_response_to0.79999304
79MP0005171_absent_coat_pigmentation0.78466353
80MP0001485_abnormal_pinna_reflex0.77021169
81MP0001986_abnormal_taste_sensitivity0.75821734
82MP0008874_decreased_physiological_sensi0.75605106
83MP0001529_abnormal_vocalization0.75465332
84MP0004085_abnormal_heartbeat0.75430788
85MP0000751_myopathy0.74581729
86MP0002752_abnormal_somatic_nervous0.73773159
87MP0003690_abnormal_glial_cell0.72424229
88MP0003938_abnormal_ear_development0.71403159
89MP0000579_abnormal_nail_morphology0.70334201
90MP0002160_abnormal_reproductive_system0.70284354
91MP0003634_abnormal_glial_cell0.70195746
92MP0003137_abnormal_impulse_conducting0.70098706
93MP0008877_abnormal_DNA_methylation0.68369587
94MP0000920_abnormal_myelination0.68153681
95MP0005535_abnormal_body_temperature0.67704610
96MP0000534_abnormal_ureter_morphology0.66709367
97MP0001299_abnormal_eye_distance/0.66688787
98MP0009250_abnormal_appendicular_skeleto0.66233155
99MP0000604_amyloidosis0.66133219
100MP0000631_abnormal_neuroendocrine_gland0.65066358
101MP0009379_abnormal_foot_pigmentation0.64090801
102MP0002081_perinatal_lethality0.63715459
103MP0003861_abnormal_nervous_system0.63536210
104MP0005195_abnormal_posterior_eye0.62947496
105MP0002876_abnormal_thyroid_physiology0.58146400
106MP0004043_abnormal_pH_regulation0.57765833
107MP0000026_abnormal_inner_ear0.57202549
108MP0005187_abnormal_penis_morphology0.56936028
109MP0004147_increased_porphyrin_level0.55338043
110MP0010769_abnormal_survival0.55315528
111MP0002638_abnormal_pupillary_reflex0.55246749
112MP0004233_abnormal_muscle_weight0.54149599
113MP0002837_dystrophic_cardiac_calcinosis0.52897610
114MP0010768_mortality/aging0.52225658
115MP0010770_preweaning_lethality0.52183585
116MP0002082_postnatal_lethality0.52183585
117MP0003283_abnormal_digestive_organ0.51529091
118MP0002234_abnormal_pharynx_morphology0.51345318
119MP0005409_darkened_coat_color0.50554588
120MP0001664_abnormal_digestion0.50366910

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.46717024
2Myokymia (HP:0002411)6.79029459
3Progressive cerebellar ataxia (HP:0002073)6.32126939
4Focal seizures (HP:0007359)6.00712424
5Visual hallucinations (HP:0002367)5.69122902
6Action tremor (HP:0002345)5.25064007
7Epileptic encephalopathy (HP:0200134)5.11618935
8Febrile seizures (HP:0002373)5.11618798
9Atonic seizures (HP:0010819)5.01595344
10Absence seizures (HP:0002121)4.49103480
11Gaze-evoked nystagmus (HP:0000640)4.45536601
12Dialeptic seizures (HP:0011146)4.11942422
13Broad-based gait (HP:0002136)4.10011993
14Generalized tonic-clonic seizures (HP:0002069)3.90137830
15Dysdiadochokinesis (HP:0002075)3.84140059
16Hyperventilation (HP:0002883)3.67774990
17Dysmetria (HP:0001310)3.62704907
18Genetic anticipation (HP:0003743)3.58265931
19Impaired smooth pursuit (HP:0007772)3.41205533
20Abnormality of the lower motor neuron (HP:0002366)3.40817333
21Scanning speech (HP:0002168)3.34383682
22Impaired vibration sensation in the lower limbs (HP:0002166)3.32330393
23Poor eye contact (HP:0000817)3.27600151
24Truncal ataxia (HP:0002078)3.26780444
25Abnormality of binocular vision (HP:0011514)3.25766381
26Diplopia (HP:0000651)3.25766381
27Hemiparesis (HP:0001269)3.15954130
28Supranuclear gaze palsy (HP:0000605)3.15444389
29Depression (HP:0000716)3.07252526
30Abnormality of ocular smooth pursuit (HP:0000617)3.07185803
31Drooling (HP:0002307)3.00300563
32Excessive salivation (HP:0003781)3.00300563
33Hemiplegia (HP:0002301)2.99718015
34Intention tremor (HP:0002080)2.98618628
35Dysmetric saccades (HP:0000641)2.95467092
36Amblyopia (HP:0000646)2.92653422
37Mutism (HP:0002300)2.90605020
38Impaired social interactions (HP:0000735)2.89897177
39Abnormal social behavior (HP:0012433)2.89897177
40Anxiety (HP:0000739)2.87647774
41Spastic tetraparesis (HP:0001285)2.85675735
42Abnormal eating behavior (HP:0100738)2.79164344
43Absent speech (HP:0001344)2.72751024
44Postural instability (HP:0002172)2.67060926
45Epileptiform EEG discharges (HP:0011182)2.65757626
46Stereotypic behavior (HP:0000733)2.55526812
47Type II lissencephaly (HP:0007260)2.49087808
48Amyotrophic lateral sclerosis (HP:0007354)2.48295360
49Fetal akinesia sequence (HP:0001989)2.46592117
50Urinary bladder sphincter dysfunction (HP:0002839)2.41651303
51Ankle clonus (HP:0011448)2.38671212
52EEG with generalized epileptiform discharges (HP:0011198)2.33930589
53Hypothermia (HP:0002045)2.33168732
54Status epilepticus (HP:0002133)2.32996575
55Progressive inability to walk (HP:0002505)2.32524294
56Annular pancreas (HP:0001734)2.29393090
57Gait ataxia (HP:0002066)2.28021304
58Cerebral inclusion bodies (HP:0100314)2.27696067
59Ventricular fibrillation (HP:0001663)2.27073361
60Bradykinesia (HP:0002067)2.22813800
61Impaired vibratory sensation (HP:0002495)2.22626795
62Aplasia involving bones of the upper limbs (HP:0009823)2.19702184
63Aplasia of the phalanges of the hand (HP:0009802)2.19702184
64Aplasia involving bones of the extremities (HP:0009825)2.19702184
65Hypsarrhythmia (HP:0002521)2.18646781
66Lower limb asymmetry (HP:0100559)2.17176275
67Incomplete penetrance (HP:0003829)2.17164345
68Abnormality of the corticospinal tract (HP:0002492)2.16310052
69Spastic gait (HP:0002064)2.13187924
70Focal dystonia (HP:0004373)2.12536176
71Horizontal nystagmus (HP:0000666)2.12016473
72Neurofibrillary tangles (HP:0002185)2.11885400
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10161739
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.10161739
75Agitation (HP:0000713)2.08956069
76Insomnia (HP:0100785)2.07847248
77Megalencephaly (HP:0001355)2.06107460
78Protruding tongue (HP:0010808)2.05149186
79Limb ataxia (HP:0002070)2.04705009
80Abnormality of salivation (HP:0100755)2.03172753
81Abnormality of saccadic eye movements (HP:0000570)2.02379805
82Aplasia/Hypoplasia of the brainstem (HP:0007362)2.02364803
83Hypoplasia of the brainstem (HP:0002365)2.02364803
84Pointed chin (HP:0000307)2.00873136
85Cerebellar dysplasia (HP:0007033)2.00590272
86Abnormal pupillary function (HP:0007686)2.00024419
87Obstructive sleep apnea (HP:0002870)1.96073684
88Urinary urgency (HP:0000012)1.95767964
89Psychosis (HP:0000709)1.93502095
90Torticollis (HP:0000473)1.93202675
91Inability to walk (HP:0002540)1.92570078
92Aplasia/Hypoplasia of the tibia (HP:0005772)1.92216328
93Short tibia (HP:0005736)1.92191157
94Papilledema (HP:0001085)1.92171926
95Generalized myoclonic seizures (HP:0002123)1.91908321
96Sleep apnea (HP:0010535)1.91443097
97Retinal dysplasia (HP:0007973)1.90217281
98Elfin facies (HP:0004428)1.89510671
99Lissencephaly (HP:0001339)1.89441425
100Aqueductal stenosis (HP:0002410)1.89052219
101Inappropriate behavior (HP:0000719)1.86874415
102Atrophy/Degeneration involving motor neurons (HP:0007373)1.85249299
103Oligodactyly (hands) (HP:0001180)1.82421886
104Spastic tetraplegia (HP:0002510)1.82053098
105Blue irides (HP:0000635)1.80946003
106Overriding aorta (HP:0002623)1.79547110
107Decreased circulating renin level (HP:0003351)1.79135645
108Renal duplication (HP:0000075)1.79131218
109Hepatoblastoma (HP:0002884)1.77506107
110Bundle branch block (HP:0011710)1.76563737
111Tetraplegia (HP:0002445)1.76555773
112Abnormality of the labia minora (HP:0012880)1.73714302
113Pachygyria (HP:0001302)1.73242540
114Cerebral hypomyelination (HP:0006808)1.72560653
115Postural tremor (HP:0002174)1.72420339
116Polyphagia (HP:0002591)1.71110712
117Lower limb muscle weakness (HP:0007340)1.71046391
118Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70651766
119Short 4th metacarpal (HP:0010044)1.70651766
120Choroideremia (HP:0001139)1.70139446
121Limb hypertonia (HP:0002509)1.68509782
122Autism (HP:0000717)1.67664560
123Palpebral edema (HP:0100540)1.67416213
124Neuronal loss in central nervous system (HP:0002529)1.67218937
125Limb dystonia (HP:0002451)1.66952446
126Increased circulating renin level (HP:0000848)1.66608799
127Double outlet right ventricle (HP:0001719)1.66494305
128Congenital malformation of the right heart (HP:0011723)1.66494305
129Morphological abnormality of the pyramidal tract (HP:0002062)1.66060853
130Termporal pattern (HP:0011008)1.65508927
131Insidious onset (HP:0003587)1.65508927
132Spinal canal stenosis (HP:0003416)1.65272918
133Thyroid-stimulating hormone excess (HP:0002925)1.63828088
134Nasal speech (HP:0001611)1.61956873
135Abnormal pancreas size (HP:0012094)1.60986297
136Akinesia (HP:0002304)1.60202555
137Optic nerve hypoplasia (HP:0000609)1.58440044
138Sacral dimple (HP:0000960)1.57762724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.14918810
2EPHA43.95323194
3MARK13.07804078
4MAP3K93.02313079
5MINK12.95798983
6MAP3K42.94486870
7MAP2K72.55689327
8MAP3K102.31491339
9RIPK42.31155306
10CAMKK12.09488815
11DAPK22.09114600
12NTRK22.08580033
13PRPF4B2.08281212
14MAP3K122.06045492
15PAK62.01021988
16CASK1.93758849
17MAP2K41.88353227
18DAPK11.76008015
19PRKD31.74725893
20KSR11.72846778
21PLK21.68304695
22CAMKK21.66649054
23STK381.64573296
24PRKCG1.64010998
25DYRK21.58863973
26PNCK1.57378177
27KSR21.55627441
28TNIK1.51959497
29SIK21.49998351
30MAPK131.48435509
31CDK51.47387757
32CAMK2B1.31163386
33GRK51.30042384
34CAMK2A1.23687076
35LIMK11.22792326
36CDK191.20783346
37RPS6KA21.16830652
38PTK2B1.14874416
39BMPR21.13716724
40NTRK11.13198017
41CAMK11.12607332
42SGK21.12200101
43FES1.09747172
44RIPK11.02938518
45SGK4941.01124469
46SGK2231.01124469
47MAP3K130.99075968
48WNK30.98760284
49MAPK150.97937649
50DYRK1A0.96820399
51CDK180.92088693
52CDK30.91764964
53ARAF0.90609556
54TAF10.89456451
55PHKG10.89318673
56PHKG20.89318673
57CDK150.89287230
58NME10.88513256
59TYRO30.88052406
60SGK30.87917184
61PINK10.85653509
62SGK10.84383612
63CDK140.82663722
64SIK30.82369489
65UHMK10.81852332
66STK110.78818544
67CDK11A0.77253733
68PRKCH0.77004629
69PDK10.74096344
70WNK10.73243944
71TSSK60.72533217
72MAP3K20.72441890
73RAF10.71207526
74LATS20.70859495
75LMTK20.68423095
76PLK40.67533005
77INSRR0.66940989
78LATS10.65898792
79BRAF0.65319191
80CAMK40.64798316
81ADRBK20.64627628
82CAMK2D0.63534820
83PKN10.61692311
84CAMK2G0.60700673
85OXSR10.60159260
86PRKCE0.59244964
87PAK30.59233397
88CSNK1G10.59177955
89CAMK1G0.58799955
90ALK0.58593225
91FER0.58211490
92BMPR1B0.56407142
93RET0.55722829
94PRKCZ0.54730310
95MARK20.54561238
96MAP3K70.54180495
97FYN0.53274903
98RPS6KA30.52879108
99NEK60.52547494
100CDC42BPA0.52059445
101MAP2K10.51865342
102FGR0.51215183
103RPS6KA60.50337211
104PDPK10.50075869
105TNK20.49686159
106CSNK1G20.48486569
107TAOK20.47567113
108BCR0.47262767
109RPS6KL10.46578230
110RPS6KC10.46578230
111ROCK20.45450571
112ERBB30.43952333
113ROCK10.43075365
114CSNK1A1L0.42081843
115AKT30.41996186
116PRKG10.41002644
117IRAK20.40644676
118MAPK100.40100719
119PRKCA0.36982241
120CSNK1G30.36740462
121MKNK20.36393331
122DMPK0.36161751
123MAPK120.36120729
124RPS6KB10.34752495
125MAP3K60.34650885
126PRKCB0.34637452
127CSNK1A10.32441883
128PRKACA0.32420286
129CSNK1E0.31481231
130WEE10.30914858
131ADRBK10.30018650
132PRKDC0.29787702

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.54115886
2Long-term potentiation_Homo sapiens_hsa047203.21422712
3Glutamatergic synapse_Homo sapiens_hsa047243.01299750
4Circadian entrainment_Homo sapiens_hsa047133.00405947
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.97056559
6Synaptic vesicle cycle_Homo sapiens_hsa047212.80559336
7GABAergic synapse_Homo sapiens_hsa047272.65991535
8Amphetamine addiction_Homo sapiens_hsa050312.62332096
9Morphine addiction_Homo sapiens_hsa050322.45545916
10Salivary secretion_Homo sapiens_hsa049702.37253562
11Olfactory transduction_Homo sapiens_hsa047402.29170204
12Long-term depression_Homo sapiens_hsa047302.21439058
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18322580
14Taste transduction_Homo sapiens_hsa047422.14706325
15Dopaminergic synapse_Homo sapiens_hsa047282.12707527
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.99758459
17Gastric acid secretion_Homo sapiens_hsa049711.96608212
18Insulin secretion_Homo sapiens_hsa049111.90084180
19Cholinergic synapse_Homo sapiens_hsa047251.83750728
20Calcium signaling pathway_Homo sapiens_hsa040201.78636560
21Oxytocin signaling pathway_Homo sapiens_hsa049211.65506441
22Serotonergic synapse_Homo sapiens_hsa047261.64651886
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64255123
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56624656
25Renin secretion_Homo sapiens_hsa049241.54759618
26GnRH signaling pathway_Homo sapiens_hsa049121.41962181
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40237810
28cAMP signaling pathway_Homo sapiens_hsa040241.35622658
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34400879
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27957375
31Type II diabetes mellitus_Homo sapiens_hsa049301.24417989
32Cocaine addiction_Homo sapiens_hsa050301.24382102
33Gap junction_Homo sapiens_hsa045401.24211242
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22919406
35Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.16933478
36Collecting duct acid secretion_Homo sapiens_hsa049661.13748205
37Estrogen signaling pathway_Homo sapiens_hsa049151.13165034
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11632750
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10901143
40Axon guidance_Homo sapiens_hsa043601.10818791
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09804866
42Parkinsons disease_Homo sapiens_hsa050121.09076006
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07652853
44Glioma_Homo sapiens_hsa052141.06921018
45Pancreatic secretion_Homo sapiens_hsa049721.06768808
46Oxidative phosphorylation_Homo sapiens_hsa001901.06718470
47Melanogenesis_Homo sapiens_hsa049161.02341734
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01073123
49ErbB signaling pathway_Homo sapiens_hsa040120.94429707
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.90255455
51Basal cell carcinoma_Homo sapiens_hsa052170.89878180
52Hedgehog signaling pathway_Homo sapiens_hsa043400.89429465
53Thyroid hormone synthesis_Homo sapiens_hsa049180.89136165
54Oocyte meiosis_Homo sapiens_hsa041140.86444936
55Butanoate metabolism_Homo sapiens_hsa006500.86019621
56Cardiac muscle contraction_Homo sapiens_hsa042600.85859445
57Fatty acid biosynthesis_Homo sapiens_hsa000610.84278634
58Choline metabolism in cancer_Homo sapiens_hsa052310.82803389
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.80458820
60Histidine metabolism_Homo sapiens_hsa003400.77745012
61African trypanosomiasis_Homo sapiens_hsa051430.70238704
62Dilated cardiomyopathy_Homo sapiens_hsa054140.68806578
63MAPK signaling pathway_Homo sapiens_hsa040100.68782002
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67430009
65Vibrio cholerae infection_Homo sapiens_hsa051100.66018132
66Dorso-ventral axis formation_Homo sapiens_hsa043200.65789836
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64367474
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63871866
69Inositol phosphate metabolism_Homo sapiens_hsa005620.63496191
70VEGF signaling pathway_Homo sapiens_hsa043700.62434193
71Hippo signaling pathway_Homo sapiens_hsa043900.62130007
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60562992
73Huntingtons disease_Homo sapiens_hsa050160.59504047
74Phototransduction_Homo sapiens_hsa047440.59317300
75Rap1 signaling pathway_Homo sapiens_hsa040150.55972189
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.55531976
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54461124
78Arginine biosynthesis_Homo sapiens_hsa002200.53409684
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53283701
80Ras signaling pathway_Homo sapiens_hsa040140.53243697
81Protein export_Homo sapiens_hsa030600.52464093
82Glucagon signaling pathway_Homo sapiens_hsa049220.50450979
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.49870896
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.49616970
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48062178
86Steroid biosynthesis_Homo sapiens_hsa001000.47935234
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47293008
88Type I diabetes mellitus_Homo sapiens_hsa049400.47239344
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46651817
90Wnt signaling pathway_Homo sapiens_hsa043100.46593765
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46537428
92mTOR signaling pathway_Homo sapiens_hsa041500.42968616
93Bile secretion_Homo sapiens_hsa049760.42677746
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42054076
95Circadian rhythm_Homo sapiens_hsa047100.42020516
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37039025
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36948592
98Ether lipid metabolism_Homo sapiens_hsa005650.36920102
99Endocytosis_Homo sapiens_hsa041440.36120579
100beta-Alanine metabolism_Homo sapiens_hsa004100.35251383
101Phenylalanine metabolism_Homo sapiens_hsa003600.35186379
102Non-small cell lung cancer_Homo sapiens_hsa052230.34357931
103Alzheimers disease_Homo sapiens_hsa050100.33999750
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33526633
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32723856
106Mineral absorption_Homo sapiens_hsa049780.32562362
107Chemokine signaling pathway_Homo sapiens_hsa040620.32485868
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32217962
109Endometrial cancer_Homo sapiens_hsa052130.31821282
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31657013
111Ovarian steroidogenesis_Homo sapiens_hsa049130.31062378
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30936588
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30692931
114Nitrogen metabolism_Homo sapiens_hsa009100.29610889
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29424308
116Alcoholism_Homo sapiens_hsa050340.28699654
117TGF-beta signaling pathway_Homo sapiens_hsa043500.28677676
118Fatty acid metabolism_Homo sapiens_hsa012120.28408000
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26712872
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25587931
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19579103
122Prion diseases_Homo sapiens_hsa050200.18588863
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17345110
124Colorectal cancer_Homo sapiens_hsa052100.17202232

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »