SHISA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerulus development (GO:0032835)9.88420591
2limb bud formation (GO:0060174)8.24820988
3kidney mesenchyme development (GO:0072074)7.73484782
4prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060527.21700566
5lens fiber cell development (GO:0070307)7.17940871
6metanephric mesenchyme development (GO:0072075)6.95822323
7epithelial cell differentiation involved in kidney development (GO:0035850)6.57004982
8notochord development (GO:0030903)6.51628790
9axon ensheathment in central nervous system (GO:0032291)6.02040252
10central nervous system myelination (GO:0022010)6.02040252
11endocardial cushion morphogenesis (GO:0003203)5.92103964
12heart valve formation (GO:0003188)5.72716620
13cell proliferation involved in metanephros development (GO:0072203)5.69853538
14regulation of vascular endothelial growth factor signaling pathway (GO:1900746)5.61641326
15lateral sprouting from an epithelium (GO:0060601)5.54530106
16lung-associated mesenchyme development (GO:0060484)5.54139526
17regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.48021059
18mesenchymal cell differentiation involved in renal system development (GO:2001012)5.39422631
19mesenchymal cell differentiation involved in kidney development (GO:0072161)5.39422631
20cell differentiation involved in kidney development (GO:0061005)5.28315262
21nephron tubule formation (GO:0072079)5.24924303
22regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.22786049
23mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.16633928
24mesonephros development (GO:0001823)5.16559002
25presynaptic membrane assembly (GO:0097105)5.09654507
26male sex determination (GO:0030238)5.06635776
27mesenchymal to epithelial transition (GO:0060231)5.00412657
28negative regulation of axon guidance (GO:1902668)4.86058206
29cell differentiation involved in metanephros development (GO:0072202)4.79880546
30negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.77161018
31metanephros development (GO:0001656)4.74806726
32regulation of glomerulus development (GO:0090192)4.71067296
33digestive tract morphogenesis (GO:0048546)4.67623691
34neuronal stem cell maintenance (GO:0097150)4.63985628
35eye photoreceptor cell differentiation (GO:0001754)4.57968613
36photoreceptor cell differentiation (GO:0046530)4.57968613
37negative regulation of metanephros development (GO:0072217)4.55163513
38regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.54441418
39cell proliferation involved in kidney development (GO:0072111)4.53754603
40outer ear morphogenesis (GO:0042473)4.51002596
41negative regulation of chondrocyte differentiation (GO:0032331)4.49855315
42lung lobe morphogenesis (GO:0060463)4.49821557
43epithelial tube branching involved in lung morphogenesis (GO:0060441)4.48333152
44proximal/distal pattern formation (GO:0009954)4.40900594
45organ growth (GO:0035265)4.39594188
46lymph vessel development (GO:0001945)4.37810290
47regulation of axon guidance (GO:1902667)4.37363869
48diterpenoid biosynthetic process (GO:0016102)4.36511563
49neural crest cell development (GO:0014032)4.33806558
50positive regulation of vascular permeability (GO:0043117)4.33755953
51diaphragm development (GO:0060539)4.29427551
52regulation of apoptotic process involved in morphogenesis (GO:1902337)4.22051070
53branching involved in prostate gland morphogenesis (GO:0060442)4.19188259
54paraxial mesoderm development (GO:0048339)4.17889872
55branching involved in ureteric bud morphogenesis (GO:0001658)4.17697758
56positive regulation of metanephros development (GO:0072216)4.15770383
57metanephric epithelium development (GO:0072207)4.04370995
58skeletal muscle organ development (GO:0060538)4.01915635
59lymphangiogenesis (GO:0001946)3.98149868
60negative regulation of homotypic cell-cell adhesion (GO:0034111)3.96840756
61lens morphogenesis in camera-type eye (GO:0002089)3.96029329
62presynaptic membrane organization (GO:0097090)3.95803322
63positive regulation of mesonephros development (GO:0061213)3.95243512
64positive regulation of male gonad development (GO:2000020)3.92537454
65epithelial cell differentiation involved in prostate gland development (GO:0060742)3.90118725
66cell-cell signaling involved in cell fate commitment (GO:0045168)3.89035289
67mesonephric tubule development (GO:0072164)3.83381211
68mesenchymal cell development (GO:0014031)3.82857407
69positive regulation of extracellular matrix organization (GO:1903055)3.82612865
70pattern specification involved in kidney development (GO:0061004)3.81773227
71ureteric bud development (GO:0001657)3.77422144
72mesonephric epithelium development (GO:0072163)3.76696834
73regulation of heart morphogenesis (GO:2000826)3.74544854
74embryonic camera-type eye development (GO:0031076)3.69241670
75cochlea morphogenesis (GO:0090103)3.68205465
76regulation of mesonephros development (GO:0061217)3.68093630
77positive regulation of RNA splicing (GO:0033120)3.68047140
78regulation of mesenchymal cell apoptotic process (GO:2001053)3.67879534
79developmental induction (GO:0031128)3.67120013
80negative regulation of kidney development (GO:0090185)3.65709690
81negative regulation of axon extension involved in axon guidance (GO:0048843)3.64231947
82mesenchymal cell differentiation (GO:0048762)3.63802236
83regulation of male gonad development (GO:2000018)3.58376617
84cartilage condensation (GO:0001502)3.58113247
85cell aggregation (GO:0098743)3.58113247
86embryonic forelimb morphogenesis (GO:0035115)3.57910983
87regulation of axon extension involved in axon guidance (GO:0048841)3.57775536
88lung epithelium development (GO:0060428)3.55888535
89Sertoli cell development (GO:0060009)3.54273302
90negative regulation of myoblast differentiation (GO:0045662)3.53810332
91forelimb morphogenesis (GO:0035136)3.51781304
92positive regulation of chondrocyte differentiation (GO:0032332)3.46028270
93negative regulation of smoothened signaling pathway (GO:0045879)3.44989660
94regulation of metanephros development (GO:0072215)3.44481003
95forebrain neuron differentiation (GO:0021879)3.43885418
96nephron epithelium morphogenesis (GO:0072088)3.43737633
97nephron tubule morphogenesis (GO:0072078)3.43737633
98branch elongation of an epithelium (GO:0060602)3.42987715
99regulation of cell proliferation involved in kidney development (GO:1901722)3.40810195
100renal filtration (GO:0097205)3.40465014
101regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.40131359
102embryonic skeletal joint morphogenesis (GO:0060272)3.36277824
103regulation of non-canonical Wnt signaling pathway (GO:2000050)3.35711589
104midgut development (GO:0007494)3.34246747
105regulation of osteoblast proliferation (GO:0033688)3.33310548
106endothelium development (GO:0003158)3.31618094
107mesenchymal cell proliferation (GO:0010463)3.31491412
108vitamin A metabolic process (GO:0006776)3.31438916
109cranial suture morphogenesis (GO:0060363)3.31140040
110response to parathyroid hormone (GO:0071107)3.31071169
111embryonic digestive tract development (GO:0048566)3.30151371
112cranial nerve structural organization (GO:0021604)3.29664654
113stem cell development (GO:0048864)3.29153663
114regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.26795417
115DNA integration (GO:0015074)3.26142947
116negative regulation of cartilage development (GO:0061037)3.25493127
117face development (GO:0060324)3.25013368
118positive regulation of mesenchymal cell proliferation (GO:0002053)3.23778006
119negative regulation of astrocyte differentiation (GO:0048712)3.20770603
120branching involved in labyrinthine layer morphogenesis (GO:0060670)3.20542016
121positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.19143714
122regulation of organ formation (GO:0003156)3.17845032
123forebrain neuron development (GO:0021884)3.17688556
124embryonic viscerocranium morphogenesis (GO:0048703)3.15837330
125renal tubule morphogenesis (GO:0061333)3.15808916
126positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.15257824
127positive regulation of cardiac muscle cell proliferation (GO:0060045)3.14167774
128endothelial cell chemotaxis (GO:0035767)3.12381008
129positive regulation of cardiac muscle tissue growth (GO:0055023)3.11879377
130regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.11832102
131regulation of kidney development (GO:0090183)3.08454476
132embryonic heart tube development (GO:0035050)3.07610518
133outflow tract septum morphogenesis (GO:0003148)3.07505815
134prostate gland growth (GO:0060736)3.07275512
135establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.06898128
136mitochondrion transport along microtubule (GO:0047497)3.06898128
137positive regulation of cell adhesion mediated by integrin (GO:0033630)3.06619387
138axis elongation (GO:0003401)3.05482011
139tongue development (GO:0043586)3.04082577
140mesenchyme morphogenesis (GO:0072132)3.03052851
141regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.02127902
142mesenchyme development (GO:0060485)3.01917312
143coronary vasculature morphogenesis (GO:0060977)3.01415160
144mesodermal cell differentiation (GO:0048333)3.00983850
145positive regulation of protein kinase C signaling (GO:0090037)2.99653358
146bone morphogenesis (GO:0060349)2.99477253
147positive regulation of cartilage development (GO:0061036)2.98697768
148retinal rod cell development (GO:0046548)2.98443585
149positive regulation of kidney development (GO:0090184)2.98256045
150epithelial cell fate commitment (GO:0072148)2.98180883
151terpenoid biosynthetic process (GO:0016114)2.95650642
152chondrocyte proliferation (GO:0035988)2.95175289
153segment specification (GO:0007379)2.93176697
154appendage development (GO:0048736)2.92138081
155limb development (GO:0060173)2.92138081
156somatic stem cell division (GO:0048103)2.91917106
157heart valve morphogenesis (GO:0003179)2.91900087
158wound healing, spreading of epidermal cells (GO:0035313)2.91823173
159neuron projection extension involved in neuron projection guidance (GO:1902284)2.91284360
160axon extension involved in axon guidance (GO:0048846)2.91284360
161branching involved in salivary gland morphogenesis (GO:0060445)2.91221670
162facial nerve structural organization (GO:0021612)2.89624921
163kidney epithelium development (GO:0072073)2.88968208
164regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.88627515
165regulation of mesenchymal cell proliferation (GO:0010464)2.86933522
166positive regulation of glomerulus development (GO:0090193)2.85894183
167dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.84946725
168chondrocyte differentiation (GO:0002062)2.84870335
169regulation of smooth muscle cell differentiation (GO:0051150)2.84101781
170regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.83416490
171regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.83152913
172positive regulation of Rho protein signal transduction (GO:0035025)2.81203942
173establishment of mitochondrion localization (GO:0051654)2.80002640
174inner ear receptor cell differentiation (GO:0060113)2.79991340
175mammary gland development (GO:0030879)2.75168802
176neuron cell-cell adhesion (GO:0007158)2.74500559
177vasculogenesis (GO:0001570)2.70235876
178respiratory tube development (GO:0030323)2.69703875
179glomerular visceral epithelial cell development (GO:0072015)14.0327726
180glomerular basement membrane development (GO:0032836)12.9983202
181glomerular epithelial cell development (GO:0072310)12.5590689
182otic vesicle formation (GO:0030916)11.4935262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.83507277
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.64173725
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.34494664
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.34494664
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.34494664
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.24124086
7EED_16625203_ChIP-ChIP_MESCs_Mouse3.13419628
8EZH2_22144423_ChIP-Seq_EOC_Human3.12719116
9WT1_19549856_ChIP-ChIP_CCG9911_Human3.07576278
10AR_21572438_ChIP-Seq_LNCaP_Human2.78891837
11PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.77783383
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.68185578
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.60752834
14RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.52717982
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.47178543
16* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.40315619
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38317808
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38317808
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34813266
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33960469
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26188342
22RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.24979674
23* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22666023
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19569334
25* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18124400
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.15103772
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.15078667
28TRIM28_21343339_ChIP-Seq_HEK293_Human2.14634170
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.13807777
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13293760
31TCF3_18692474_ChIP-Seq_MEFs_Mouse2.12180555
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.09592045
33GBX2_23144817_ChIP-Seq_PC3_Human2.09404524
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03080414
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.96507191
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.93868452
37TBX3_20139965_ChIP-Seq_ESCs_Mouse1.89061253
38TBX3_20139965_ChIP-Seq_MESCs_Mouse1.88818510
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84813211
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84433385
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83590512
42FUS_26573619_Chip-Seq_HEK293_Human1.81313908
43WT1_25993318_ChIP-Seq_PODOCYTE_Human1.80936466
44* RNF2_27304074_Chip-Seq_NSC_Mouse1.80296526
45* RNF2_27304074_Chip-Seq_ESCs_Mouse1.79754166
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.79303422
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.76369957
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74534113
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.74346360
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68619154
51* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67884885
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66985025
53AR_21909140_ChIP-Seq_LNCAP_Human1.66033278
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64605148
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.61526917
56POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.58486387
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58125038
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.57814161
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.57663475
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.56530176
61SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.55621028
62AHR_22903824_ChIP-Seq_MCF-7_Human1.55130839
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.53987581
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53023965
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.51998001
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.51763092
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50555129
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.49417367
69* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48268065
70E2F7_22180533_ChIP-Seq_HELA_Human1.47931870
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.46403163
72EWS_26573619_Chip-Seq_HEK293_Human1.46138171
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40874063
74P300_19829295_ChIP-Seq_ESCs_Human1.40433186
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39989136
76TCF3_18692474_ChIP-Seq_MESCs_Mouse1.39187730
77TP53_18474530_ChIP-ChIP_U2OS_Human1.38386974
78RXR_22108803_ChIP-Seq_LS180_Human1.37462024
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35706998
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.35654169
81* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34047595
82TAF15_26573619_Chip-Seq_HEK293_Human1.33491345
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32692646
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32213561
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30803486
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29095837
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28038682
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27545198
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27472758
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.27427211
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.27400571
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.27217903
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26247435
94NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.25939865
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25547550
96* SMAD4_21799915_ChIP-Seq_A2780_Human1.25524686
97TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23607294
98* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23258172
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21977013
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20131180
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19974859
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.18774875
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17629419
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17467560
105CDX2_20551321_ChIP-Seq_CACO-2_Human1.16731479
106* RING1B_27294783_Chip-Seq_ESCs_Mouse1.16527159
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16083169
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15772996
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14231582
110GATA1_26923725_Chip-Seq_HPCs_Mouse1.12140895
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10218860
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10062125
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09658703
114PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08525285
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07917565
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07187903
117FLI1_27457419_Chip-Seq_LIVER_Mouse1.06871615
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06651223
119TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06130673
120CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05354997
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04531507
122* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03778628
123* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03600394
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02755202
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02755202
126SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01768702
127SOX9_26525672_Chip-Seq_HEART_Mouse0.99139009
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.99053858
129FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98438227
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97889478
131SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97426547
132CJUN_26792858_Chip-Seq_BT549_Human0.97386086
133* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96826879
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.96016369
135BRD4_25478319_ChIP-Seq_HGPS_Human0.95896330
136KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95753900
137* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95542305
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95207256
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94996509
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94190259
141IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93915174
142PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93679364
143PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93371951
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.91718569

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.27180950
2MP0003942_abnormal_urinary_system4.68856517
3MP0005623_abnormal_meninges_morphology4.52686557
4MP0003123_paternal_imprinting3.73808445
5MP0000534_abnormal_ureter_morphology3.62736736
6MP0010030_abnormal_orbit_morphology3.60711654
7MP0003122_maternal_imprinting3.54340840
8MP0004272_abnormal_basement_membrane3.47208449
9MP0002249_abnormal_larynx_morphology3.34893747
10MP0005670_abnormal_white_adipose3.30043478
11MP0002653_abnormal_ependyma_morphology3.01834003
12MP0003941_abnormal_skin_development2.92965275
13MP0005503_abnormal_tendon_morphology2.88035680
14MP0001879_abnormal_lymphatic_vessel2.85407060
15MP0000678_abnormal_parathyroid_gland2.84326941
16MP0003385_abnormal_body_wall2.75230447
17MP0003121_genomic_imprinting2.65557200
18MP0010368_abnormal_lymphatic_system2.56706395
19MP0009250_abnormal_appendicular_skeleto2.50618407
20MP0002282_abnormal_trachea_morphology2.46432338
21MP0009780_abnormal_chondrocyte_physiolo2.44619915
22MP0003938_abnormal_ear_development2.35979920
23MP0000049_abnormal_middle_ear2.19446724
24MP0002932_abnormal_joint_morphology1.99853005
25MP0003115_abnormal_respiratory_system1.92853404
26MP0003937_abnormal_limbs/digits/tail_de1.77824550
27MP0000537_abnormal_urethra_morphology1.74669531
28MP0000462_abnormal_digestive_system1.69914722
29MP0001958_emphysema1.68376307
30MP0002938_white_spotting1.65069553
31MP0001286_abnormal_eye_development1.61488789
32MP0002135_abnormal_kidney_morphology1.56468036
33MP0000566_synostosis1.55827343
34MP0003315_abnormal_perineum_morphology1.51244746
35MP0003755_abnormal_palate_morphology1.50948071
36MP0003935_abnormal_craniofacial_develop1.49517791
37MP0002089_abnormal_postnatal_growth/wei1.48699479
38MP0009053_abnormal_anal_canal1.47931707
39MP0005409_darkened_coat_color1.46845723
40MP0002638_abnormal_pupillary_reflex1.44031470
41MP0000516_abnormal_urinary_system1.42821170
42MP0005367_renal/urinary_system_phenotyp1.42821170
43MP0002233_abnormal_nose_morphology1.40673084
44MP0002109_abnormal_limb_morphology1.39866747
45MP0005508_abnormal_skeleton_morphology1.38224232
46MP0004885_abnormal_endolymph1.28795849
47MP0002116_abnormal_craniofacial_bone1.26920300
48MP0005197_abnormal_uvea_morphology1.26718105
49MP0000163_abnormal_cartilage_morphology1.25836816
50MP0002697_abnormal_eye_size1.22540148
51MP0002115_abnormal_skeleton_extremities1.19778873
52MP0004233_abnormal_muscle_weight1.18428633
53MP0002114_abnormal_axial_skeleton1.17630016
54MP0005171_absent_coat_pigmentation1.16826609
55MP0003787_abnormal_imprinting1.16647989
56MP0000003_abnormal_adipose_tissue1.14818611
57MP0002177_abnormal_outer_ear1.14810160
58MP0001346_abnormal_lacrimal_gland1.14222890
59MP0000579_abnormal_nail_morphology1.11079364
60MP0000026_abnormal_inner_ear1.09360444
61MP0001849_ear_inflammation1.08538798
62MP0001485_abnormal_pinna_reflex1.07821236
63MP0004858_abnormal_nervous_system1.07562007
64MP0009672_abnormal_birth_weight1.05660251
65MP0000778_abnormal_nervous_system1.05409705
66MP0000538_abnormal_urinary_bladder1.05261902
67MP0005248_abnormal_Harderian_gland1.04649884
68MP0005666_abnormal_adipose_tissue1.04177206
69MP0003279_aneurysm1.03294989
70MP0000767_abnormal_smooth_muscle1.02360840
71MP0002102_abnormal_ear_morphology1.00811667
72MP0005083_abnormal_biliary_tract0.99001258
73MP0000751_myopathy0.97168344
74MP0003936_abnormal_reproductive_system0.96581746
75MP0002896_abnormal_bone_mineralization0.96217787
76MP0002113_abnormal_skeleton_development0.95869916
77MP0001614_abnormal_blood_vessel0.95369327
78MP0010678_abnormal_skin_adnexa0.95079750
79MP0000432_abnormal_head_morphology0.94535719
80MP0004084_abnormal_cardiac_muscle0.93083074
81MP0005375_adipose_tissue_phenotype0.93070621
82MP0000428_abnormal_craniofacial_morphol0.92057049
83MP0001293_anophthalmia0.91615713
84MP0002128_abnormal_blood_circulation0.91606017
85MP0001324_abnormal_eye_pigmentation0.90969334
86MP0002081_perinatal_lethality0.89829973
87MP0005595_abnormal_vascular_smooth0.89559133
88MP0006138_congestive_heart_failure0.89399305
89MP0002925_abnormal_cardiovascular_devel0.89122202
90MP0000613_abnormal_salivary_gland0.87056764
91MP0002751_abnormal_autonomic_nervous0.86426926
92MP0003878_abnormal_ear_physiology0.85660677
93MP0005377_hearing/vestibular/ear_phenot0.85660677
94MP0005193_abnormal_anterior_eye0.85615267
95MP0002127_abnormal_cardiovascular_syste0.85254615
96MP0000383_abnormal_hair_follicle0.84775019
97MP0001175_abnormal_lung_morphology0.84722515
98MP0009384_cardiac_valve_regurgitation0.83544351
99MP0002136_abnormal_kidney_physiology0.83084826
100MP0002111_abnormal_tail_morphology0.82467282
101MP0001340_abnormal_eyelid_morphology0.82416777
102MP0003943_abnormal_hepatobiliary_system0.82371741
103MP0002160_abnormal_reproductive_system0.82077622
104MP0003890_abnormal_embryonic-extraembry0.81315624
105MP0001963_abnormal_hearing_physiology0.78696194
106MP0002163_abnormal_gland_morphology0.78548070
107MP0002108_abnormal_muscle_morphology0.77648320
108MP0001299_abnormal_eye_distance/0.77178563
109MP0001915_intracranial_hemorrhage0.76280606
110MP0002092_abnormal_eye_morphology0.75579599
111MP0003861_abnormal_nervous_system0.75471510
112MP0001270_distended_abdomen0.75139144
113MP0002998_abnormal_bone_remodeling0.74585479
114MP0000631_abnormal_neuroendocrine_gland0.73010608
115MP0000230_abnormal_systemic_arterial0.72107899
116MP0000762_abnormal_tongue_morphology0.72061140
117MP0004134_abnormal_chest_morphology0.71060004
118MP0004957_abnormal_blastocyst_morpholog0.69667316
119MP0001784_abnormal_fluid_regulation0.69178113
120MP0000647_abnormal_sebaceous_gland0.68280367
121MP0002234_abnormal_pharynx_morphology0.67770382
122MP0005084_abnormal_gallbladder_morpholo0.67036458
123MP0003634_abnormal_glial_cell0.66426199
124MP0000733_abnormal_muscle_development0.66191250
125MP0002085_abnormal_embryonic_tissue0.65828143
126MP0000467_abnormal_esophagus_morphology0.64743729
127MP0002133_abnormal_respiratory_system0.64738970
128MP0005388_respiratory_system_phenotype0.64738970
129MP0001661_extended_life_span0.64576779
130MP0003091_abnormal_cell_migration0.64208476
131MP0006072_abnormal_retinal_apoptosis0.63821403
132MP0000749_muscle_degeneration0.63487019
133MP0002295_abnormal_pulmonary_circulatio0.63329519
134MP0000569_abnormal_digit_pigmentation0.63274681
135MP0005167_abnormal_blood-brain_barrier0.63259470
136MP0003567_abnormal_fetal_cardiomyocyte0.62925949
137MP0004142_abnormal_muscle_tone0.62886456
138MP0003119_abnormal_digestive_system0.61630063
139MP0004133_heterotaxia0.60624182
140MP0002277_abnormal_respiratory_mucosa0.59298073
141MP0005257_abnormal_intraocular_pressure0.58554515
142MP0005390_skeleton_phenotype0.57799616
143MP0001177_atelectasis0.57575418
144MP0005187_abnormal_penis_morphology0.57184506
145MP0003984_embryonic_growth_retardation0.55644866

Predicted human phenotypes

RankGene SetZ-score
1Mesangial abnormality (HP:0001966)7.76490404
2Focal segmental glomerulosclerosis (HP:0000097)7.17660185
3Neonatal short-limb short stature (HP:0008921)6.44254738
4Aplasia involving bones of the upper limbs (HP:0009823)5.87841810
5Aplasia of the phalanges of the hand (HP:0009802)5.87841810
6Aplasia involving bones of the extremities (HP:0009825)5.87841810
7Glomerulosclerosis (HP:0000096)5.29883458
8Bronchomalacia (HP:0002780)5.13704610
9Hypoalbuminemia (HP:0003073)5.00092303
10Abnormal albumin level (HP:0012116)5.00092303
11Stage 5 chronic kidney disease (HP:0003774)4.98028374
12Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.76536363
13Tubular atrophy (HP:0000092)4.15017322
14Abnormality of the middle phalanges of the toes (HP:0010183)4.14454995
15Renal duplication (HP:0000075)4.10516260
16Nephroblastoma (Wilms tumor) (HP:0002667)4.05409067
17Hepatoblastoma (HP:0002884)4.01787621
18Broad metatarsal (HP:0001783)4.01671728
19Embryonal renal neoplasm (HP:0011794)3.94876676
20Esophageal atresia (HP:0002032)3.84934560
21Alacrima (HP:0000522)3.73622405
22Abnormality of the distal phalanx of the thumb (HP:0009617)3.69986970
23Diastasis recti (HP:0001540)3.68263992
24Duplication of thumb phalanx (HP:0009942)3.66630044
25Bifid scrotum (HP:0000048)3.62304751
26Abnormality of incisor morphology (HP:0011063)3.54948934
27Megalencephaly (HP:0001355)3.45706855
28Nephritis (HP:0000123)3.44681730
29Hypoplastic left heart (HP:0004383)3.41436633
30Nephrotic syndrome (HP:0000100)3.38342023
31Metaphyseal dysplasia (HP:0100255)3.33183930
32Sex reversal (HP:0012245)3.31728656
33Abnormal sex determination (HP:0012244)3.31728656
34Split foot (HP:0001839)3.28231832
35Morphological abnormality of the middle ear (HP:0008609)3.28123129
36Abnormality of the 2nd finger (HP:0004100)3.27000720
37Abnormality of the labia minora (HP:0012880)3.25627614
38Abnormality of the phalanges of the 2nd finger (HP:0009541)3.25037883
39Conical tooth (HP:0000698)3.20836264
40Stenosis of the external auditory canal (HP:0000402)3.19485451
41Glomerulonephritis (HP:0000099)3.17954131
42Missing ribs (HP:0000921)3.13271801
43Midline defect of the nose (HP:0004122)3.12185105
44Anomalous pulmonary venous return (HP:0010772)3.06814200
4511 pairs of ribs (HP:0000878)3.03977242
46Gastrointestinal atresia (HP:0002589)3.02677236
47Decreased lacrimation (HP:0000633)3.00209871
48Thickened helices (HP:0000391)2.98195448
49Coronal craniosynostosis (HP:0004440)2.93957206
50True hermaphroditism (HP:0010459)2.92396352
51Neoplasm of the heart (HP:0100544)2.91150114
52Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.89915853
53Vertebral hypoplasia (HP:0008417)2.89915853
54Broad distal phalanx of finger (HP:0009836)2.88621817
55Shallow orbits (HP:0000586)2.86892808
56Renal dysplasia (HP:0000110)2.85953503
57Humeroradial synostosis (HP:0003041)2.79459553
58Synostosis involving the elbow (HP:0003938)2.79459553
59Ulnar bowing (HP:0003031)2.78843462
60Hypoplastic heart (HP:0001961)2.75745664
61Corneal erosion (HP:0200020)2.73022474
62Mixed hearing impairment (HP:0000410)2.72083915
63Recurrent corneal erosions (HP:0000495)2.70420913
64Tracheomalacia (HP:0002779)2.65058467
65Aplasia/Hypoplasia of the sternum (HP:0006714)2.62642980
66Abnormality of the pulmonary veins (HP:0011718)2.60546890
67Broad toe (HP:0001837)2.60055059
68Septo-optic dysplasia (HP:0100842)2.58817404
69Abnormal lung lobation (HP:0002101)2.55963691
70Short phalanx of the thumb (HP:0009660)2.55487761
71Abnormality of the nasolacrimal system (HP:0000614)2.55066547
72Neonatal respiratory distress (HP:0002643)2.54900628
73Abnormality of the lacrimal duct (HP:0011481)2.53968410
74Broad hallux (HP:0010055)2.53968379
75Abnormality of the dental pulp (HP:0006479)2.52467213
76Visceral angiomatosis (HP:0100761)2.50669517
77Short hallux (HP:0010109)2.47957784
78Short middle phalanx of finger (HP:0005819)2.47005019
79Down-sloping shoulders (HP:0200021)2.46979469
80Xerostomia (HP:0000217)2.46590417
81Turricephaly (HP:0000262)2.45556963
82Synostosis of carpal bones (HP:0005048)2.44771463
83Abnormality of the 4th metacarpal (HP:0010012)2.43604313
84Potter facies (HP:0002009)2.41776639
85Facial shape deformation (HP:0011334)2.41776639
86Abnormality of the dental root (HP:0006486)2.40843748
87Taurodontia (HP:0000679)2.40843748
88Abnormality of permanent molar morphology (HP:0011071)2.40843748
89Proteinuria (HP:0000093)2.36601756
90Hypoproteinemia (HP:0003075)2.36267667
91Overriding aorta (HP:0002623)2.35244161
92Abnormality of the salivary glands (HP:0010286)2.35107527
93Hemangiomatosis (HP:0007461)2.34834430
94Hypoplastic scapulae (HP:0000882)2.34742253
95Aplasia/Hypoplasia of the scapulae (HP:0006713)2.34742253
96Fibular hypoplasia (HP:0003038)2.33611567
97Vertebral fusion (HP:0002948)2.31907716
98Aqueductal stenosis (HP:0002410)2.31703668
99Enlarged kidneys (HP:0000105)2.29393711
100Tubulointerstitial nephritis (HP:0001970)2.28691710
101Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.27907559
102Short 4th metacarpal (HP:0010044)2.27907559
103Absent septum pellucidum (HP:0001331)2.27765385
104Abnormality of molar (HP:0011077)2.25972726
105Abnormality of molar morphology (HP:0011070)2.25972726
106Cutaneous finger syndactyly (HP:0010554)2.23285838
107Germ cell neoplasia (HP:0100728)2.22602328
108Renal hypoplasia (HP:0000089)2.22245613
109Tibial bowing (HP:0002982)2.21738239
110Bicornuate uterus (HP:0000813)2.21532163
111Bell-shaped thorax (HP:0001591)2.20764779
112Chronic otitis media (HP:0000389)2.19638524
113Aplasia/Hypoplasia of the hallux (HP:0008362)2.19248218
114Abnormality of the incisor (HP:0000676)2.18191834
115Limited hip movement (HP:0008800)2.15841473
116Tubulointerstitial abnormality (HP:0001969)2.14052672
117Abnormal ventriculo-arterial connection (HP:0011563)2.13830537
118Transposition of the great arteries (HP:0001669)2.13830537
119Abnormal connection of the cardiac segments (HP:0011545)2.13830537
120Abnormality of dentin (HP:0010299)2.12881244
121Bilateral microphthalmos (HP:0007633)2.09025577
122Embryonal neoplasm (HP:0002898)2.08313878
123Hematuria (HP:0000790)2.05970746
124Abnormality of the antihelix (HP:0009738)2.05913397
125Bifid tongue (HP:0010297)2.05329617
126Cupped ear (HP:0000378)2.03970480
127Hypoplasia of the ulna (HP:0003022)2.02835511
128Absent radius (HP:0003974)2.02360756
129Hemivertebrae (HP:0002937)2.01431053
130Spastic diplegia (HP:0001264)2.01417415
131Anophthalmia (HP:0000528)2.01373505
132Abnormality of the fibula (HP:0002991)2.01297213
133Vaginal atresia (HP:0000148)2.00820703
134Supernumerary spleens (HP:0009799)2.00772318
1352-3 toe syndactyly (HP:0004691)1.99860329
136Arnold-Chiari malformation (HP:0002308)1.98384115
137Genital tract atresia (HP:0001827)1.97455127
138Abnormality of the septum pellucidum (HP:0007375)1.96987794
139Absent/shortened dynein arms (HP:0200106)1.94728050
140Dynein arm defect of respiratory motile cilia (HP:0012255)1.94728050
141Trigonocephaly (HP:0000243)1.94685388
142Absent forearm bone (HP:0003953)1.94555435
143Aplasia involving forearm bones (HP:0009822)1.94555435
144Choanal stenosis (HP:0000452)1.94109492
145Broad thumb (HP:0011304)1.93641934
146Supernumerary bones of the axial skeleton (HP:0009144)1.92467131
147Progressive sensorineural hearing impairment (HP:0000408)1.91876172
148Supernumerary ribs (HP:0005815)1.91542888
149Cutaneous syndactyly (HP:0012725)1.91311761
150Aplasia/Hypoplasia of the ulna (HP:0006495)1.91115350
151Nasolacrimal duct obstruction (HP:0000579)1.90632449
152Broad phalanges of the hand (HP:0009768)1.88282859
153Preaxial foot polydactyly (HP:0001841)1.87559552
154Broad finger (HP:0001500)1.86641087
155Abnormality of carpal bone ossification (HP:0006257)1.86561698
156Absent eyebrow (HP:0002223)1.85385101
157Omphalocele (HP:0001539)1.85293403
158Persistence of primary teeth (HP:0006335)1.83813043
159Partial duplication of the phalanx of hand (HP:0009999)1.83544035
160Shawl scrotum (HP:0000049)1.82595216
161Hip contracture (HP:0003273)1.82429845
162Nonprogressive disorder (HP:0003680)1.82173576
163Flared iliac wings (HP:0002869)1.80900430
164Pterygium (HP:0001059)1.80359687
165Lymphangioma (HP:0100764)1.79711483
166Nephronophthisis (HP:0000090)1.75487605
167Preauricular pit (HP:0004467)1.75482605
168Periauricular skin pits (HP:0100277)1.75482605
169Increased circulating renin level (HP:0000848)1.74993287
170Tubulointerstitial fibrosis (HP:0005576)1.73912581
171Abnormality of the fingertips (HP:0001211)1.73609202
172Aplasia of the musculature (HP:0100854)1.72801053
173Hypomagnesemia (HP:0002917)1.72708350
174Broad phalanx (HP:0006009)1.71922417
175Spinal cord lesions (HP:0100561)1.69523485
176Syringomyelia (HP:0003396)1.69523485
177Neoplasm of the liver (HP:0002896)1.67121186
178Abnormality of the parietal bone (HP:0002696)1.66143534
179Broad long bones (HP:0005622)1.65381846
180Abnormality of the renal medulla (HP:0100957)1.64737532
181Abnormal ossification of hand bones (HP:0005921)1.64523602
182Partial duplication of thumb phalanx (HP:0009944)1.63623022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK5.62279611
2WNK45.18533055
3CASK4.33921414
4EPHB24.32925823
5PINK14.29114329
6STK394.07038414
7OXSR13.70780913
8WEE13.11820752
9EPHA23.06271679
10LATS12.87557014
11MKNK12.76392397
12ERBB32.68474892
13MKNK22.57196759
14PAK42.54963932
15TAOK22.41588016
16TIE12.41097710
17BUB12.20805447
18LMTK22.14126141
19FGFR32.13877699
20WNK11.99280932
21TGFBR21.97784467
22WNK31.96429552
23TGFBR11.72562851
24MYLK1.70241877
25LIMK11.63983526
26ERBB41.62278961
27NEK11.57110324
28MAPK131.52298573
29PDGFRA1.49329447
30AKT31.49168791
31TSSK61.42864507
32NEK91.39817298
33PLK21.36159965
34MET1.36004708
35NUAK11.32862336
36MST1R1.32195133
37YES11.29132799
38NME11.22821521
39VRK21.22137170
40SRPK11.21962846
41MAPK151.21176554
42NEK21.18950963
43MAP2K31.18019823
44SIK31.17599233
45TTN1.16502251
46MAP3K101.16113788
47LATS21.15965177
48CAMK1G1.14807070
49CDK31.10241617
50PHKG21.06572333
51PHKG11.06572333
52CLK11.01156568
53ROCK11.00750797
54PKN10.94589640
55STK30.93312608
56BCR0.92866848
57FGFR10.90505799
58CAMK1D0.89931741
59PAK20.89075881
60PRKCE0.88572345
61PTK20.87081995
62STK38L0.86859535
63CDC70.86114470
64GSK3A0.80738485
65PLK40.79936826
66CAMK2B0.78390181
67PASK0.77790018
68CDK80.76260050
69EPHB10.75453345
70SGK20.74798322
71FER0.74720462
72DMPK0.74110780
73EIF2AK20.73810065
74SIK10.72686863
75PRKD30.71692608
76TNIK0.69264448
77PTK60.69112516
78UHMK10.68969647
79GRK10.68209659
80MAP3K60.66257317
81ROCK20.64399036
82NTRK30.59835120
83DDR20.59203543
84VRK10.58778016
85NEK60.58233735
86DYRK30.57008316
87SGK30.55910881
88ADRBK10.55327458
89MAPK90.54812960
90CAMKK20.53412817
91PIK3CA0.50509810
92RIPK10.48727572
93CSNK1A1L0.48305232
94MAP2K60.48141475
95MAP2K40.47941627
96CHUK0.46734955
97MINK10.46110419
98CAMK40.45264318
99TRPM70.44929950
100PDGFRB0.44635894
101CDC42BPA0.44602968
102HIPK20.44048704
103SRC0.43815162
104FGFR20.43794967
105BMPR1B0.42959910
106RPS6KA20.42115771
107MARK20.41965120
108PTK2B0.40812622
109DYRK20.40559895
110PRKACB0.40138664
111TLK10.39327315
112SGK2230.37888877
113SGK4940.37888877
114BMX0.35896562
115MAPK70.35151064
116STK100.34772130
117PDK30.34330311
118PDK40.34330311
119PRKD20.34089645
120IGF1R0.33979747
121NTRK10.33735408
122NTRK20.33643853
123CHEK20.33501747
124MTOR0.32843891
125PAK30.32716732
126DYRK1B0.31914796
127PLK10.31580653
128BRD40.30829215
129DYRK1A0.30208271
130ICK0.29539283
131TAF10.29238036
132KDR0.28652857
133ATR0.28461154
134AURKA0.27927914
135STK40.27212948
136PDK20.27023232
137CSNK1G10.26840880
138PLK30.26510968
139CHEK10.25787859
140BRSK20.25482763
141MAPKAPK20.25207037
142ERBB20.24799175
143CDK40.24204950
144CSNK1D0.24114925
145INSR0.23779916
146MOS0.23611035
147MAPK80.23285487
148AURKB0.23142953
149AKT20.22502802
150GSK3B0.22119716
151MAP3K70.17935076
152STK160.15917564
153CSNK1G20.14430712
154TYRO30.14238683
155MST40.13897677

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.40384974
2Axon guidance_Homo sapiens_hsa043603.02708289
3Renin-angiotensin system_Homo sapiens_hsa046142.78759564
4Small cell lung cancer_Homo sapiens_hsa052222.61931198
5Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.17728465
6Focal adhesion_Homo sapiens_hsa045102.16339474
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.13444238
8Ribosome_Homo sapiens_hsa030102.06997532
9Central carbon metabolism in cancer_Homo sapiens_hsa052302.06488526
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.05958874
11Basal cell carcinoma_Homo sapiens_hsa052171.92864402
12Amoebiasis_Homo sapiens_hsa051461.90892186
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.90642655
14Hippo signaling pathway_Homo sapiens_hsa043901.89089624
15Hedgehog signaling pathway_Homo sapiens_hsa043401.88997044
16Steroid biosynthesis_Homo sapiens_hsa001001.88725282
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81405503
18Sulfur relay system_Homo sapiens_hsa041221.80116810
19Protein digestion and absorption_Homo sapiens_hsa049741.76715053
20Dilated cardiomyopathy_Homo sapiens_hsa054141.74053811
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.73354240
22MicroRNAs in cancer_Homo sapiens_hsa052061.66640727
23Folate biosynthesis_Homo sapiens_hsa007901.64960612
24Adherens junction_Homo sapiens_hsa045201.62394473
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56615835
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.55314995
27Proteoglycans in cancer_Homo sapiens_hsa052051.53125608
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.43102495
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42168518
30PI3K-Akt signaling pathway_Homo sapiens_hsa041511.39354172
31Prostate cancer_Homo sapiens_hsa052151.34294351
32TGF-beta signaling pathway_Homo sapiens_hsa043501.33724966
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33550692
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26652592
35Pathways in cancer_Homo sapiens_hsa052001.26438995
36Rap1 signaling pathway_Homo sapiens_hsa040151.25701075
37Melanoma_Homo sapiens_hsa052181.24881622
38Wnt signaling pathway_Homo sapiens_hsa043101.24114956
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21118993
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14362929
41Tight junction_Homo sapiens_hsa045301.11094617
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09628860
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09374765
44Pancreatic cancer_Homo sapiens_hsa052121.08257104
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05788805
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05044509
47Glutathione metabolism_Homo sapiens_hsa004801.04624375
48N-Glycan biosynthesis_Homo sapiens_hsa005101.02205865
49Bladder cancer_Homo sapiens_hsa052190.97163884
50Viral myocarditis_Homo sapiens_hsa054160.95682383
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94769731
52Cocaine addiction_Homo sapiens_hsa050300.92940081
53Cardiac muscle contraction_Homo sapiens_hsa042600.92727464
54African trypanosomiasis_Homo sapiens_hsa051430.86206024
55Chronic myeloid leukemia_Homo sapiens_hsa052200.86098807
56Notch signaling pathway_Homo sapiens_hsa043300.85388161
57mRNA surveillance pathway_Homo sapiens_hsa030150.85066060
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82348819
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.79877104
60Melanogenesis_Homo sapiens_hsa049160.78778138
61Endometrial cancer_Homo sapiens_hsa052130.77834977
62Renal cell carcinoma_Homo sapiens_hsa052110.74878013
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.73992725
64Glycerolipid metabolism_Homo sapiens_hsa005610.73806393
65Huntingtons disease_Homo sapiens_hsa050160.73572023
66Prion diseases_Homo sapiens_hsa050200.71983437
67Cell cycle_Homo sapiens_hsa041100.71174540
68Ras signaling pathway_Homo sapiens_hsa040140.71032610
69Non-small cell lung cancer_Homo sapiens_hsa052230.69555528
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66967348
71Nicotine addiction_Homo sapiens_hsa050330.66510893
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.65751323
73PPAR signaling pathway_Homo sapiens_hsa033200.65496682
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65139521
75Lysine degradation_Homo sapiens_hsa003100.65138570
76RNA polymerase_Homo sapiens_hsa030200.64574237
77Retinol metabolism_Homo sapiens_hsa008300.64162309
78Parkinsons disease_Homo sapiens_hsa050120.63729824
79Colorectal cancer_Homo sapiens_hsa052100.63583614
80HTLV-I infection_Homo sapiens_hsa051660.62674942
81Glioma_Homo sapiens_hsa052140.62457702
82Basal transcription factors_Homo sapiens_hsa030220.62090255
83Dorso-ventral axis formation_Homo sapiens_hsa043200.62018960
84Renin secretion_Homo sapiens_hsa049240.61870372
85Alcoholism_Homo sapiens_hsa050340.61200306
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60137981
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59950693
88Selenocompound metabolism_Homo sapiens_hsa004500.59871189
89Influenza A_Homo sapiens_hsa051640.59676338
90Base excision repair_Homo sapiens_hsa034100.59266143
91Arginine and proline metabolism_Homo sapiens_hsa003300.58409797
92Salmonella infection_Homo sapiens_hsa051320.57148671
93DNA replication_Homo sapiens_hsa030300.57085175
94Rheumatoid arthritis_Homo sapiens_hsa053230.56848168
95Phagosome_Homo sapiens_hsa041450.55389462
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54908028
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54481650
98Nucleotide excision repair_Homo sapiens_hsa034200.52604471
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.51344901
100cAMP signaling pathway_Homo sapiens_hsa040240.50287481
101Mineral absorption_Homo sapiens_hsa049780.50125319
102Taste transduction_Homo sapiens_hsa047420.49645221
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49623079
104Toxoplasmosis_Homo sapiens_hsa051450.49362868
105Thyroid hormone synthesis_Homo sapiens_hsa049180.49104250
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48912353
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48261341
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.48033457
109ErbB signaling pathway_Homo sapiens_hsa040120.47827999
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46829427
111Pyruvate metabolism_Homo sapiens_hsa006200.46748122
112Biosynthesis of amino acids_Homo sapiens_hsa012300.46442333
113Osteoclast differentiation_Homo sapiens_hsa043800.45936449
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45687697
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45533813
116Proteasome_Homo sapiens_hsa030500.45446855
117Calcium signaling pathway_Homo sapiens_hsa040200.44795693
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44630235
119Thyroid cancer_Homo sapiens_hsa052160.44090159
120Gap junction_Homo sapiens_hsa045400.43961029
121Hepatitis C_Homo sapiens_hsa051600.43767727
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43716346
123TNF signaling pathway_Homo sapiens_hsa046680.43673949
124Shigellosis_Homo sapiens_hsa051310.43392145
125Platelet activation_Homo sapiens_hsa046110.42615045
126Spliceosome_Homo sapiens_hsa030400.42461903
127MAPK signaling pathway_Homo sapiens_hsa040100.41012451
128VEGF signaling pathway_Homo sapiens_hsa043700.40174184
129Starch and sucrose metabolism_Homo sapiens_hsa005000.39913229
130Salivary secretion_Homo sapiens_hsa049700.38953951
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37821926
132Malaria_Homo sapiens_hsa051440.37752155
133Insulin secretion_Homo sapiens_hsa049110.37211965
134Measles_Homo sapiens_hsa051620.36432479
135Estrogen signaling pathway_Homo sapiens_hsa049150.36077420
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.35360370
137Oxidative phosphorylation_Homo sapiens_hsa001900.35297352
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32719795
139Mismatch repair_Homo sapiens_hsa034300.29492879
140Ovarian steroidogenesis_Homo sapiens_hsa049130.28396927
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27271804

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