SHH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dopaminergic neuron differentiation (GO:0071542)9.23989412
2neuron projection extension involved in neuron projection guidance (GO:1902284)9.04478910
3axon extension involved in axon guidance (GO:0048846)9.04478910
4establishment of planar polarity (GO:0001736)7.77811638
5establishment of tissue polarity (GO:0007164)7.77811638
6negative regulation of axon guidance (GO:1902668)7.01758749
7lens fiber cell development (GO:0070307)6.75068743
8G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071996.39466668
9lateral sprouting from an epithelium (GO:0060601)6.39150582
10* lung epithelium development (GO:0060428)6.07678647
11regulation of chemokine-mediated signaling pathway (GO:0070099)5.79637005
12positive regulation of gastrulation (GO:2000543)5.76758014
13retinal ganglion cell axon guidance (GO:0031290)5.63921463
14primitive streak formation (GO:0090009)5.51240814
15negative chemotaxis (GO:0050919)5.47530616
16planar cell polarity pathway involved in neural tube closure (GO:0090179)5.28967369
17establishment of nucleus localization (GO:0040023)5.27856716
18negative regulation of axon extension involved in axon guidance (GO:0048843)5.21266349
19glomerular filtration (GO:0003094)5.14540374
20* midbrain development (GO:0030901)5.12890376
21paraxial mesoderm development (GO:0048339)5.02697482
22dendritic spine morphogenesis (GO:0060997)4.94198371
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.93108710
24midgut development (GO:0007494)4.71103187
25epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.70526096
26regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.63697892
27neuronal stem cell maintenance (GO:0097150)4.59950252
28renal filtration (GO:0097205)4.53790437
29regulation of axon guidance (GO:1902667)4.53458102
30positive regulation of BMP signaling pathway (GO:0030513)4.51125549
31cardiovascular system development (GO:0072358)4.43045135
32glomerular basement membrane development (GO:0032836)4.33480125
33negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.32337964
34face development (GO:0060324)4.27559304
35* somite development (GO:0061053)4.26764536
36negative regulation of axon extension (GO:0030517)4.21133036
37epithelial cell differentiation involved in prostate gland development (GO:0060742)4.20168953
38behavioral response to nicotine (GO:0035095)4.14694558
39negative regulation of oligodendrocyte differentiation (GO:0048715)4.04222485
40regulation of glucokinase activity (GO:0033131)3.99586848
41regulation of hexokinase activity (GO:1903299)3.99586848
42neuron fate determination (GO:0048664)3.99143305
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.96615224
44response to pheromone (GO:0019236)3.95257381
45* limb bud formation (GO:0060174)3.89857900
46regulation of somitogenesis (GO:0014807)3.89211920
47axonal fasciculation (GO:0007413)3.88217561
48kidney morphogenesis (GO:0060993)3.85842479
49negative regulation of leukocyte chemotaxis (GO:0002689)3.80380126
50endocardial cushion morphogenesis (GO:0003203)3.76632173
51mesenchyme morphogenesis (GO:0072132)3.75015126
52cell surface receptor signaling pathway involved in heart development (GO:0061311)3.73840638
53DNA unwinding involved in DNA replication (GO:0006268)3.67793288
54chondrocyte development (GO:0002063)3.59384576
55cochlea morphogenesis (GO:0090103)3.58225605
56urogenital system development (GO:0001655)3.54593316
57establishment of apical/basal cell polarity (GO:0035089)3.51905789
58negative regulation of embryonic development (GO:0045992)3.51417196
59epithelial cell fate commitment (GO:0072148)3.49865831
60* hindbrain development (GO:0030902)3.46715176
61* regulation of mesenchymal cell apoptotic process (GO:2001053)3.46132720
62convergent extension (GO:0060026)3.43149743
63nephron tubule morphogenesis (GO:0072078)3.43116039
64nephron epithelium morphogenesis (GO:0072088)3.43116039
65Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.42161669
66establishment or maintenance of monopolar cell polarity (GO:0061339)3.42146299
67establishment of monopolar cell polarity (GO:0061162)3.42146299
68protein polyglutamylation (GO:0018095)3.41443147
69detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.36459807
70negative regulation of chemotaxis (GO:0050922)3.35365273
71notochord development (GO:0030903)3.34329203
72type B pancreatic cell development (GO:0003323)3.30953431
73Notch signaling involved in heart development (GO:0061314)3.30333666
74post-anal tail morphogenesis (GO:0036342)3.28891113
75regulation of establishment of planar polarity (GO:0090175)3.28456646
76DNA double-strand break processing (GO:0000729)3.27684943
77central nervous system myelination (GO:0022010)3.24636166
78axon ensheathment in central nervous system (GO:0032291)3.24636166
79epithelial cilium movement (GO:0003351)3.24318309
80spinal cord development (GO:0021510)3.23828746
81innervation (GO:0060384)3.23803836
82somite rostral/caudal axis specification (GO:0032525)3.23541447
83negative regulation of B cell mediated immunity (GO:0002713)3.21196619
84negative regulation of immunoglobulin mediated immune response (GO:0002890)3.21196619
85L-fucose catabolic process (GO:0042355)3.19373734
86fucose catabolic process (GO:0019317)3.19373734
87L-fucose metabolic process (GO:0042354)3.19373734
88central nervous system neuron development (GO:0021954)3.18337695
89striated muscle cell proliferation (GO:0014855)3.17218417
90translesion synthesis (GO:0019985)3.15984341
91heart valve formation (GO:0003188)3.12428765
92regulation of axon extension involved in axon guidance (GO:0048841)3.12055909
93positive regulation of epithelial to mesenchymal transition (GO:0010718)3.08535668
94hair follicle development (GO:0001942)3.06509541
95otic vesicle formation (GO:0030916)3.04747911
96cell proliferation in forebrain (GO:0021846)3.04720902
97* dorsal/ventral neural tube patterning (GO:0021904)3.04706275
98muscle cell proliferation (GO:0033002)3.02598860
99regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.02044430
100water-soluble vitamin biosynthetic process (GO:0042364)3.01042766
101negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99548269
102indolalkylamine metabolic process (GO:0006586)2.97656120
103telomere maintenance via semi-conservative replication (GO:0032201)2.96243548
104DNA strand elongation involved in DNA replication (GO:0006271)2.94439700
105negative regulation of epidermis development (GO:0045683)2.93784905
106neuronal action potential (GO:0019228)2.93226419
107endocrine pancreas development (GO:0031018)2.92904998
108left/right axis specification (GO:0070986)2.92713904
109cranial nerve development (GO:0021545)2.92150869
110cranial nerve morphogenesis (GO:0021602)2.90577414
111regulation of non-canonical Wnt signaling pathway (GO:2000050)2.90049189
112nucleus localization (GO:0051647)2.89472342
113neural tube formation (GO:0001841)2.89333473
114glomerular epithelial cell development (GO:0072310)2.88027026
115cilium movement (GO:0003341)2.87925846
116embryonic axis specification (GO:0000578)2.87915174
117* embryonic foregut morphogenesis (GO:0048617)2.86852417
118peptidyl-tyrosine autophosphorylation (GO:0038083)2.85979544
119deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85832131
120* negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.85263408
121DNA strand elongation (GO:0022616)2.84818808
122nonmotile primary cilium assembly (GO:0035058)2.82681671
123negative regulation of axonogenesis (GO:0050771)2.81655940
124positive regulation of tolerance induction (GO:0002645)2.81563909
125serotonin metabolic process (GO:0042428)2.81362948
126heparan sulfate proteoglycan metabolic process (GO:0030201)2.81249124
127epithelial tube branching involved in lung morphogenesis (GO:0060441)2.80842420
128DNA integration (GO:0015074)2.80386116
129axoneme assembly (GO:0035082)2.79160933
130establishment or maintenance of apical/basal cell polarity (GO:0035088)2.77333259
131establishment or maintenance of bipolar cell polarity (GO:0061245)2.77333259
132negative regulation of astrocyte differentiation (GO:0048712)2.76540831
133signal transduction involved in regulation of gene expression (GO:0023019)2.76287146
134cardiac muscle cell proliferation (GO:0060038)2.74845779
135* positive regulation of embryonic development (GO:0040019)2.73702643
136mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.72613188
137negative regulation of glial cell differentiation (GO:0045686)2.68292091
138regulation of timing of cell differentiation (GO:0048505)2.67777164
139reflex (GO:0060004)2.67216799
140negative regulation of translation, ncRNA-mediated (GO:0040033)2.66880860
141regulation of translation, ncRNA-mediated (GO:0045974)2.66880860
142negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66880860
143primary amino compound metabolic process (GO:1901160)2.66788790
144pyrimidine nucleobase catabolic process (GO:0006208)2.66149658
145embryonic epithelial tube formation (GO:0001838)2.63343554
146* embryonic pattern specification (GO:0009880)2.62808962
147motor neuron axon guidance (GO:0008045)2.60722749
148tryptophan catabolic process (GO:0006569)2.60621479
149indole-containing compound catabolic process (GO:0042436)2.60621479
150indolalkylamine catabolic process (GO:0046218)2.60621479
151photoreceptor cell development (GO:0042461)2.60109519
152indole-containing compound metabolic process (GO:0042430)2.59236781
153negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.59143438
154cilium morphogenesis (GO:0060271)2.58118553
155positive regulation of meiosis (GO:0045836)2.55919564
156RNA destabilization (GO:0050779)2.55622154
157negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.53373199
158DNA deamination (GO:0045006)2.52666207
159protein K6-linked ubiquitination (GO:0085020)2.52271970
160neuron fate specification (GO:0048665)2.49556888
161dentate gyrus development (GO:0021542)2.47117527
162regulation of development, heterochronic (GO:0040034)2.45506483
163glomerulus development (GO:0032835)2.44529932
164negative regulation of epidermal cell differentiation (GO:0045605)2.44106237
165epithelial tube formation (GO:0072175)2.43985995
166regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.43464398
167platelet dense granule organization (GO:0060155)2.43257478
168intraciliary transport (GO:0042073)2.43220201
169cochlea development (GO:0090102)2.43159902
170cilium organization (GO:0044782)2.42780739
171appendage development (GO:0048736)2.42203927
172limb development (GO:0060173)2.42203927
173retinal cone cell development (GO:0046549)2.40956150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.75537968
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.13596303
3EZH2_22144423_ChIP-Seq_EOC_Human3.78555315
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.66573570
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.49712632
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.37838089
7* EED_16625203_ChIP-ChIP_MESCs_Mouse3.31144021
8* PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.13271361
9CBX2_27304074_Chip-Seq_ESCs_Mouse3.00558734
10RNF2_27304074_Chip-Seq_ESCs_Mouse2.92526900
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.85474352
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.81439642
13* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79386045
14* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.69033114
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65592611
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65592611
17* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65046132
18VDR_22108803_ChIP-Seq_LS180_Human2.62405885
19* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58603792
20* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40497744
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32890953
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31354942
23EWS_26573619_Chip-Seq_HEK293_Human2.29616006
24* TP53_20018659_ChIP-ChIP_R1E_Mouse2.27424277
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.26070525
26FUS_26573619_Chip-Seq_HEK293_Human2.25188549
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24229390
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23154091
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.22467426
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21125256
31* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18384489
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.12181569
33* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11726122
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08493528
35* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00513197
36OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.00312373
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.95367474
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90362928
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.88941586
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.81641902
41ER_23166858_ChIP-Seq_MCF-7_Human1.79202716
42GBX2_23144817_ChIP-Seq_PC3_Human1.78749611
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75464135
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.74757934
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.74442484
46SOX2_16153702_ChIP-ChIP_HESCs_Human1.73798967
47* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72401352
48* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.70943112
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70491293
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66084961
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.65988493
52TAF15_26573619_Chip-Seq_HEK293_Human1.64890473
53RNF2_27304074_Chip-Seq_NSC_Mouse1.64098098
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.64067303
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60039046
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.58252172
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53208795
58* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51650314
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50952456
60AR_21909140_ChIP-Seq_LNCAP_Human1.50382990
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48376051
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48364965
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48361023
64* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47208073
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44120196
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44058593
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.43574047
68ZNF274_21170338_ChIP-Seq_K562_Hela1.42886163
69* AR_25329375_ChIP-Seq_VCAP_Human1.42108467
70* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37520890
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36873674
72* BCAT_22108803_ChIP-Seq_LS180_Human1.36684440
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35899487
74IRF1_19129219_ChIP-ChIP_H3396_Human1.34943066
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.33433447
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31764423
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.31168288
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30195300
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29827774
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29344810
81SOX2_19829295_ChIP-Seq_ESCs_Human1.29194322
82NANOG_19829295_ChIP-Seq_ESCs_Human1.29194322
83* SMAD4_21799915_ChIP-Seq_A2780_Human1.29077091
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28708430
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.26844298
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26625766
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26220427
88MYC_18940864_ChIP-ChIP_HL60_Human1.25645918
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25284986
90* STAT3_23295773_ChIP-Seq_U87_Human1.25230966
91AR_21572438_ChIP-Seq_LNCaP_Human1.23287262
92IGF1R_20145208_ChIP-Seq_DFB_Human1.21466638
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.20654874
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19827204
95P300_19829295_ChIP-Seq_ESCs_Human1.18350673
96E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18320030
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.18047612
98TCF4_23295773_ChIP-Seq_U87_Human1.17854248
99TP53_22573176_ChIP-Seq_HFKS_Human1.17113338
100CBP_20019798_ChIP-Seq_JUKART_Human1.16886322
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16886322
102REST_21632747_ChIP-Seq_MESCs_Mouse1.15972795
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15761352
104* TCF4_22108803_ChIP-Seq_LS180_Human1.14849996
105* RUNX2_22187159_ChIP-Seq_PCA_Human1.14268186
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13851034
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13406154
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13279324
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11714984
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.11714984
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10389112
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.09838510
113SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09328341
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09154596
115* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07447752
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05935469
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05283457
118* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05194301
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05100902
120DROSHA_22980978_ChIP-Seq_HELA_Human1.04202971
121WT1_19549856_ChIP-ChIP_CCG9911_Human1.04138308
122GABP_17652178_ChIP-ChIP_JURKAT_Human1.03081609
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02403194
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02149728
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01966902
126CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01528181
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99103590
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95864388
129XRN2_22483619_ChIP-Seq_HELA_Human0.93288686
130IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91918077
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91637338
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91593815
133NANOG_16153702_ChIP-ChIP_HESCs_Human0.91509202
134* AHR_22903824_ChIP-Seq_MCF-7_Human0.91459836
135AR_19668381_ChIP-Seq_PC3_Human0.91078709
136TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90410172
137ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89853563
138TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89065841
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88641683
140EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88178978
141TTF2_22483619_ChIP-Seq_HELA_Human0.87769692
142* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86623906
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86557393
144ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85938279
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85774884
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84909227
147DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83519344
148TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83310841
149POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83310841
150CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83290723
151NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83094472
152SOX9_26525672_Chip-Seq_HEART_Mouse0.82919572
153* ARNT_22903824_ChIP-Seq_MCF-7_Human0.82251181
154SMAD3_21741376_ChIP-Seq_EPCs_Human0.81136979
155* REST_18959480_ChIP-ChIP_MESCs_Mouse0.80261525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis8.43384341
2MP0000537_abnormal_urethra_morphology4.51499490
3MP0001529_abnormal_vocalization3.88924777
4MP0010030_abnormal_orbit_morphology3.74333571
5MP0003122_maternal_imprinting3.64756646
6MP0003195_calcinosis3.21259512
7MP0002653_abnormal_ependyma_morphology3.11415900
8MP0000579_abnormal_nail_morphology2.64007921
9MP0003880_abnormal_central_pattern2.52721765
10* MP0000778_abnormal_nervous_system2.37700573
11MP0004133_heterotaxia2.35790719
12MP0003315_abnormal_perineum_morphology2.33845379
13MP0002249_abnormal_larynx_morphology2.33521625
14MP0005423_abnormal_somatic_nervous2.24621583
15MP0008961_abnormal_basal_metabolism2.21989529
16* MP0002282_abnormal_trachea_morphology2.16787712
17MP0005503_abnormal_tendon_morphology2.15166489
18MP0003136_yellow_coat_color2.13271859
19MP0009780_abnormal_chondrocyte_physiolo2.07858609
20MP0008995_early_reproductive_senescence2.04475723
21MP0005084_abnormal_gallbladder_morpholo1.98518387
22MP0004885_abnormal_endolymph1.94798251
23MP0002938_white_spotting1.90488661
24* MP0009053_abnormal_anal_canal1.88320406
25MP0003011_delayed_dark_adaptation1.84291152
26* MP0003115_abnormal_respiratory_system1.83528979
27MP0003121_genomic_imprinting1.82296807
28MP0002638_abnormal_pupillary_reflex1.77861610
29MP0000049_abnormal_middle_ear1.77363746
30MP0005551_abnormal_eye_electrophysiolog1.72419092
31MP0005076_abnormal_cell_differentiation1.71177133
32* MP0002234_abnormal_pharynx_morphology1.70781337
33* MP0002751_abnormal_autonomic_nervous1.69101066
34* MP0003938_abnormal_ear_development1.67837004
35MP0003942_abnormal_urinary_system1.64215793
36MP0001485_abnormal_pinna_reflex1.62012614
37MP0008932_abnormal_embryonic_tissue1.58932044
38* MP0002932_abnormal_joint_morphology1.58054822
39MP0002928_abnormal_bile_duct1.56844924
40* MP0000026_abnormal_inner_ear1.56064025
41MP0001984_abnormal_olfaction1.55980130
42* MP0001293_anophthalmia1.55176650
43MP0008875_abnormal_xenobiotic_pharmacok1.55016705
44MP0009379_abnormal_foot_pigmentation1.53431275
45MP0003890_abnormal_embryonic-extraembry1.53038200
46MP0006072_abnormal_retinal_apoptosis1.51821497
47MP0008877_abnormal_DNA_methylation1.49752715
48MP0001486_abnormal_startle_reflex1.43689650
49MP0002277_abnormal_respiratory_mucosa1.43262048
50* MP0003937_abnormal_limbs/digits/tail_de1.40898057
51MP0006292_abnormal_olfactory_placode1.40097166
52MP0002876_abnormal_thyroid_physiology1.38645600
53MP0005253_abnormal_eye_physiology1.38198928
54* MP0003861_abnormal_nervous_system1.37891744
55* MP0002116_abnormal_craniofacial_bone1.36767381
56MP0004742_abnormal_vestibular_system1.36704047
57MP0005508_abnormal_skeleton_morphology1.28820866
58MP0000569_abnormal_digit_pigmentation1.28284245
59MP0002184_abnormal_innervation1.28278039
60MP0002160_abnormal_reproductive_system1.27427414
61MP0000762_abnormal_tongue_morphology1.25859990
62* MP0000467_abnormal_esophagus_morphology1.24191311
63MP0008789_abnormal_olfactory_epithelium1.22946436
64MP0000534_abnormal_ureter_morphology1.22682267
65MP0001905_abnormal_dopamine_level1.21233843
66MP0002272_abnormal_nervous_system1.20553467
67MP0002089_abnormal_postnatal_growth/wei1.18596001
68* MP0002092_abnormal_eye_morphology1.17733520
69MP0000427_abnormal_hair_cycle1.16859846
70MP0008872_abnormal_physiological_respon1.16554723
71* MP0000383_abnormal_hair_follicle1.16340300
72MP0000631_abnormal_neuroendocrine_gland1.14731281
73MP0009745_abnormal_behavioral_response1.14585574
74MP0000538_abnormal_urinary_bladder1.14025771
75MP0004145_abnormal_muscle_electrophysio1.13975731
76MP0004142_abnormal_muscle_tone1.11331373
77MP0006276_abnormal_autonomic_nervous1.11077040
78* MP0003119_abnormal_digestive_system1.09951848
79* MP0002697_abnormal_eye_size1.08776582
80MP0002111_abnormal_tail_morphology1.08246979
81MP0001299_abnormal_eye_distance/1.07030621
82MP0000647_abnormal_sebaceous_gland1.06883057
83* MP0005195_abnormal_posterior_eye1.06566591
84* MP0000955_abnormal_spinal_cord1.05339388
85* MP0003755_abnormal_palate_morphology1.04454992
86MP0000516_abnormal_urinary_system1.04369772
87MP0005367_renal/urinary_system_phenotyp1.04369772
88MP0005389_reproductive_system_phenotype1.02398318
89* MP0001286_abnormal_eye_development1.01923601
90MP0002572_abnormal_emotion/affect_behav1.01853439
91MP0002837_dystrophic_cardiac_calcinosis1.01360779
92MP0001986_abnormal_taste_sensitivity0.98947230
93* MP0002152_abnormal_brain_morphology0.96887934
94MP0001963_abnormal_hearing_physiology0.96411014
95MP0010094_abnormal_chromosome_stability0.94749055
96* MP0002085_abnormal_embryonic_tissue0.94425636
97* MP0001944_abnormal_pancreas_morphology0.92360673
98MP0009250_abnormal_appendicular_skeleto0.90486212
99MP0002067_abnormal_sensory_capabilities0.88043743
100* MP0002084_abnormal_developmental_patter0.87733161
101MP0001324_abnormal_eye_pigmentation0.86166529
102MP0005386_behavior/neurological_phenoty0.84462318
103MP0004924_abnormal_behavior0.84462318
104MP0004381_abnormal_hair_follicle0.84050430
105MP0009046_muscle_twitch0.83332036
106MP0002733_abnormal_thermal_nociception0.83146054
107MP0001663_abnormal_digestive_system0.83098343
108MP0003111_abnormal_nucleus_morphology0.82653005
109MP0005257_abnormal_intraocular_pressure0.82200914
110MP0005171_absent_coat_pigmentation0.80975192
111* MP0005381_digestive/alimentary_phenotyp0.80454333
112* MP0000163_abnormal_cartilage_morphology0.79405343
113MP0002736_abnormal_nociception_after0.79372679
114MP0001346_abnormal_lacrimal_gland0.79190848
115* MP0000428_abnormal_craniofacial_morphol0.79060211
116MP0002108_abnormal_muscle_morphology0.78602245
117* MP0002064_seizures0.78186810
118MP0001440_abnormal_grooming_behavior0.77294899
119* MP0002109_abnormal_limb_morphology0.77256152
120MP0002138_abnormal_hepatobiliary_system0.76990879
121* MP0002233_abnormal_nose_morphology0.76311279
122MP0005248_abnormal_Harderian_gland0.75772467
123* MP0002081_perinatal_lethality0.75301547
124MP0001919_abnormal_reproductive_system0.74914521
125MP0003385_abnormal_body_wall0.74733240
126* MP0002102_abnormal_ear_morphology0.74026365
127MP0000350_abnormal_cell_proliferation0.73940878
128* MP0002882_abnormal_neuron_morphology0.73909505
129MP0003693_abnormal_embryo_hatching0.73828944
130MP0001958_emphysema0.73507310
131* MP0002752_abnormal_somatic_nervous0.73125586
132MP0002557_abnormal_social/conspecific_i0.72788444
133* MP0002098_abnormal_vibrissa_morphology0.72518615
134* MP0003935_abnormal_craniofacial_develop0.72228427
135* MP0001943_abnormal_respiration0.72055090
136MP0005645_abnormal_hypothalamus_physiol0.71756132
137MP0001501_abnormal_sleep_pattern0.71499236
138MP0003091_abnormal_cell_migration0.71063928
139MP0003077_abnormal_cell_cycle0.70969114
140MP0002063_abnormal_learning/memory/cond0.70258288
141MP0004272_abnormal_basement_membrane0.69402177
142MP0005394_taste/olfaction_phenotype0.68478304
143MP0004859_abnormal_synaptic_plasticity0.67924055
144MP0002177_abnormal_outer_ear0.67803297
145MP0001968_abnormal_touch/_nociception0.66927405
146MP0003137_abnormal_impulse_conducting0.65752554
147MP0001188_hyperpigmentation0.64245413
148MP0005197_abnormal_uvea_morphology0.63963929
149MP0002735_abnormal_chemical_nociception0.63675295
150* MP0005391_vision/eye_phenotype0.63125681
151MP0005646_abnormal_pituitary_gland0.62153252

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)6.18037820
2Aplasia of the musculature (HP:0100854)4.80149997
3Absent phalangeal crease (HP:0006109)4.28868483
4Pancreatic cysts (HP:0001737)4.12569547
5True hermaphroditism (HP:0010459)3.95467572
6Ridged nail (HP:0001807)3.67818915
7Abnormality of the right ventricle (HP:0001707)3.67430650
8Abnormal finger flexion creases (HP:0006143)3.64955101
9Pancreatic fibrosis (HP:0100732)3.61086895
10Abnormality of midbrain morphology (HP:0002418)3.60329877
11Molar tooth sign on MRI (HP:0002419)3.60329877
12Keratoconus (HP:0000563)3.54070554
13Increased corneal curvature (HP:0100692)3.54070554
14Glomerulonephritis (HP:0000099)3.53273438
15Short middle phalanx of the 5th finger (HP:0004220)3.50855203
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.49613650
17Renal duplication (HP:0000075)3.37543451
18Aplasia/Hypoplasia involving the musculature (HP:0001460)3.33910614
19Congenital stationary night blindness (HP:0007642)3.26991053
20Nephronophthisis (HP:0000090)3.22046971
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.21194564
22Absent/shortened dynein arms (HP:0200106)3.21194564
23Septo-optic dysplasia (HP:0100842)3.19465540
24Abnormality of the upper arm (HP:0001454)3.18582539
25Partial duplication of thumb phalanx (HP:0009944)3.13145699
26Abnormality of the renal cortex (HP:0011035)3.12820220
27Megalencephaly (HP:0001355)3.07612872
28Exostoses (HP:0100777)3.03350233
29Intestinal atresia (HP:0011100)3.02269613
30Synostosis of carpal bones (HP:0005048)3.02033474
31Heterochromia iridis (HP:0001100)3.00312989
32Pterygium (HP:0001059)2.96162631
33Pendular nystagmus (HP:0012043)2.94358781
34Coronal craniosynostosis (HP:0004440)2.94017850
35Aplasia cutis congenita (HP:0001057)2.90869203
36Neonatal short-limb short stature (HP:0008921)2.86909696
37Type II lissencephaly (HP:0007260)2.82452643
38Limited elbow extension (HP:0001377)2.80908852
39Abnormality of the renal medulla (HP:0100957)2.78764069
40Partial duplication of the phalanx of hand (HP:0009999)2.77318369
41Ectopic kidney (HP:0000086)2.75393280
42Patellar dislocation (HP:0002999)2.71138135
43Aqueductal stenosis (HP:0002410)2.70149271
44Cystic liver disease (HP:0006706)2.68250867
45Mesomelia (HP:0003027)2.64972329
46Absent radius (HP:0003974)2.61561842
47Renal cortical cysts (HP:0000803)2.61112579
48Hypothermia (HP:0002045)2.56247765
49Abnormal respiratory epithelium morphology (HP:0012253)2.56001526
50Abnormal respiratory motile cilium morphology (HP:0005938)2.56001526
51Carpal synostosis (HP:0009702)2.55563516
52Aplasia involving forearm bones (HP:0009822)2.54453680
53Absent forearm bone (HP:0003953)2.54453680
54Bifid tongue (HP:0010297)2.54330209
55Abnormality of the proximal phalanges of the hand (HP:0009834)2.49812841
56Aplasia/hypoplasia of the uterus (HP:0008684)2.49133926
57Duplication of thumb phalanx (HP:0009942)2.48636423
58Tubular atrophy (HP:0000092)2.44254704
59Patellar aplasia (HP:0006443)2.43852125
60Abnormality of the phalanges of the 2nd finger (HP:0009541)2.42284591
61Down-sloping shoulders (HP:0200021)2.41658505
62Abnormality of the radial head (HP:0003995)2.39570769
63Labial hypoplasia (HP:0000066)2.39069337
64Abnormal ciliary motility (HP:0012262)2.37571351
65Cerebellar dysplasia (HP:0007033)2.37306975
66Tubulointerstitial fibrosis (HP:0005576)2.35676115
67Alacrima (HP:0000522)2.32554139
68Sclerocornea (HP:0000647)2.31063667
69Skull defect (HP:0001362)2.30825559
70Medial flaring of the eyebrow (HP:0010747)2.29992582
71Anencephaly (HP:0002323)2.29673741
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.27403811
73High anterior hairline (HP:0009890)2.27079309
74Chronic hepatic failure (HP:0100626)2.22158864
75Short tibia (HP:0005736)2.21876176
76Short 5th finger (HP:0009237)2.21847113
77Bifid scrotum (HP:0000048)2.20603433
78Fibular aplasia (HP:0002990)2.20367518
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.20311116
80Congenital, generalized hypertrichosis (HP:0004540)2.19731551
81Overfolded helix (HP:0000396)2.19152148
82Aplasia/Hypoplasia of the patella (HP:0006498)2.19043619
83Synostosis involving bones of the lower limbs (HP:0009138)2.18309719
84Synostosis involving bones of the feet (HP:0009140)2.18309719
85Abnormal rod and cone electroretinograms (HP:0008323)2.18184905
86Male pseudohermaphroditism (HP:0000037)2.16058771
87Oligodactyly (hands) (HP:0001180)2.15765698
88Aplasia/Hypoplasia of the ulna (HP:0006495)2.14211804
89* Anophthalmia (HP:0000528)2.14098886
90Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.14069457
91Broad distal phalanx of finger (HP:0009836)2.13547731
92Optic nerve hypoplasia (HP:0000609)2.12970570
93Tarsal synostosis (HP:0008368)2.12600074
94Chorioretinal atrophy (HP:0000533)2.12223088
95Abolished electroretinogram (ERG) (HP:0000550)2.12015530
96Increased nuchal translucency (HP:0010880)2.11955954
97Esophageal atresia (HP:0002032)2.11321355
98Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.09943429
99Short 1st metacarpal (HP:0010034)2.09013942
100Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.09013942
101* Maternal diabetes (HP:0009800)2.08770275
102Hypoplastic female external genitalia (HP:0012815)2.07567462
103Rhizomelia (HP:0008905)2.07191471
104Synostosis involving bones of the hand (HP:0004278)2.06934311
105Morphological abnormality of the middle ear (HP:0008609)2.06789726
106Midline defect of the nose (HP:0004122)2.06633728
107* Bilateral microphthalmos (HP:0007633)2.05447131
108Chin dimple (HP:0010751)2.05183429
109Abnormality of the phalanges of the 5th finger (HP:0004213)2.04890912
110Oligodactyly (HP:0012165)2.04243847
111Hypoplasia of the ulna (HP:0003022)2.03794699
112Limb dystonia (HP:0002451)2.03623401
113Aplasia/Hypoplasia of the tongue (HP:0010295)2.03590394
114Absent septum pellucidum (HP:0001331)2.03142040
115Lumbar hyperlordosis (HP:0002938)2.02947360
116Broad toe (HP:0001837)2.02336828
117Truncus arteriosus (HP:0001660)2.01625220
118Synostosis involving the elbow (HP:0003938)2.00764538
119Humeroradial synostosis (HP:0003041)2.00764538
120Abnormality of the humerus (HP:0003063)2.00737253
121Aplasia involving bones of the upper limbs (HP:0009823)2.00299951
122Aplasia of the phalanges of the hand (HP:0009802)2.00299951
123Aplasia involving bones of the extremities (HP:0009825)2.00299951
124Disproportionate short-trunk short stature (HP:0003521)1.99905709
125Abdominal situs inversus (HP:0003363)1.98228951
126Abnormality of abdominal situs (HP:0011620)1.98228951
127Mixed hearing impairment (HP:0000410)1.97764530
128Attenuation of retinal blood vessels (HP:0007843)1.96718579
129Thickened helices (HP:0000391)1.94853570
130Abnormality of the 1st metacarpal (HP:0010009)1.93405046
131Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.93252135
132Hypoplastic iliac wings (HP:0002866)1.93152985
133Abnormality of the parathyroid morphology (HP:0011766)1.92737309
134Short hallux (HP:0010109)1.92608490
135Aplasia/Hypoplasia of the lens (HP:0008063)1.91750293
136Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.90969356
137Abnormality of the pubic bones (HP:0003172)1.90651826
138Abnormally folded helix (HP:0008544)1.89218685
139Abnormality of the salivary glands (HP:0010286)1.88979035
140Horseshoe kidney (HP:0000085)1.88339640
141Osteoarthritis (HP:0002758)1.88302473
142Thyroid-stimulating hormone excess (HP:0002925)1.88154234
143Hypoplastic pelvis (HP:0008839)1.88023800
144Elfin facies (HP:0004428)1.87891574
145Aplasia/Hypoplasia of the hallux (HP:0008362)1.87487430
146Genital tract atresia (HP:0001827)1.86917172
147Furrowed tongue (HP:0000221)1.86815300
148Lissencephaly (HP:0001339)1.86517781
149Abnormal respiratory motile cilium physiology (HP:0012261)1.85516930
150Methylmalonic acidemia (HP:0002912)1.85511648
151Cheekbone underdevelopment (HP:0010669)1.85210789
152Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.83673205
153Vaginal atresia (HP:0000148)1.82565985
154Absent thumb (HP:0009777)1.82545596
155* Triphalangeal thumb (HP:0001199)1.82164487
156Decreased lacrimation (HP:0000633)1.80936662
157Abnormal drinking behavior (HP:0030082)1.80921296
158Polydipsia (HP:0001959)1.80921296
159Hallux valgus (HP:0001822)1.80831229
160Ankyloglossia (HP:0010296)1.80310234
161Optic disc pallor (HP:0000543)1.80027327
162Bile duct proliferation (HP:0001408)1.80018462
163Abnormal biliary tract physiology (HP:0012439)1.80018462
164Hypoplasia of the uterus (HP:0000013)1.79867583
16511 pairs of ribs (HP:0000878)1.79679111
166Short middle phalanx of finger (HP:0005819)1.79556767
167Abnormality of the aortic arch (HP:0012303)1.79406261
168Aplasia/Hypoplasia of the earlobes (HP:0009906)1.78737926
169Aplasia/Hypoplasia of the sternum (HP:0006714)1.77542805
170Aplasia/Hypoplasia of the fibula (HP:0006492)1.76618683
171Stenosis of the external auditory canal (HP:0000402)1.75586867
172Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.74878810
173Convex nasal ridge (HP:0000444)1.74566810
174Increased number of teeth (HP:0011069)1.74505222
175Gastrointestinal atresia (HP:0002589)1.73979152
176Renal hypoplasia (HP:0000089)1.73721944
177Abnormality of the septum pellucidum (HP:0007375)1.73564184
178Tubulointerstitial abnormality (HP:0001969)1.72857409
179Abnormality of the nasal septum (HP:0000419)1.72130944
180Thyroiditis (HP:0100646)1.71236598
181Congenital hepatic fibrosis (HP:0002612)1.70910960
182Symphalangism affecting the phalanges of the hand (HP:0009773)1.70908679
183Gait imbalance (HP:0002141)1.70707349
184Short phalanx of the thumb (HP:0009660)1.70558695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB26.86692746
2KSR16.52066773
3SIK35.98655249
4BUB15.35834827
5BCR3.76016628
6FRK3.36293958
7MAPK153.18265063
8PNCK3.04618192
9GRK12.51393819
10VRK22.44400905
11NUAK12.43862764
12ADRBK22.40591220
13ERBB22.35570560
14TAOK32.31393493
15MINK12.22363284
16MAP3K102.05457966
17MAP3K42.01885278
18WNK31.99836495
19TNIK1.93879089
20DYRK31.89933773
21FGFR21.84829897
22UHMK11.82036257
23MAP4K21.79571360
24PASK1.75970543
25WEE11.75471374
26ZAK1.74361828
27CDC71.70653836
28MKNK11.69433012
29STK391.66846370
30CDK81.64253342
31MUSK1.57461129
32TGFBR11.48374630
33WNK41.46474992
34PINK11.46156960
35MKNK21.38611194
36TAF11.33357582
37IRAK21.33231448
38STK161.31189195
39CDK191.31020231
40TXK1.24141403
41NEK61.19537854
42CCNB11.16826897
43MELK1.15570180
44FGFR11.15558424
45OXSR11.11720938
46SIK11.10200646
47PAK41.06155959
48IRAK11.05050395
49MAPKAPK31.04988889
50CDK181.04801833
51ICK1.03549559
52CSNK1G21.01988971
53CDK71.01112314
54BRSK10.98220599
55CSNK1G10.94182978
56MAP2K20.89324504
57PRKCG0.89255102
58ROCK20.88338409
59CDK120.86430931
60NME10.84705324
61STK38L0.84458922
62DYRK1B0.82736178
63ADRBK10.81272778
64MAPKAPK50.80415729
65CDK30.78424987
66GRK50.78413074
67NTRK30.76741881
68NTRK20.76092490
69AKT20.75234000
70EPHA40.73672649
71TLK10.73431581
72FGFR30.73138840
73PRKCE0.72520491
74BMPR1B0.71169775
75CDK150.70843796
76TTK0.69451618
77ATR0.68376570
78NEK10.67318108
79BRD40.66498899
80INSRR0.65813674
81CDK140.64978463
82CSNK1A1L0.64136958
83CDK11A0.63799033
84LATS10.63487342
85IKBKB0.63390651
86AURKA0.61961385
87PLK10.61325107
88MARK10.61308340
89EPHA30.61283572
90CASK0.60851073
91PLK40.60828475
92DAPK20.60241908
93YES10.60172261
94TRIM280.60139908
95AURKB0.59661564
96NEK20.56684186
97PLK30.56654814
98PHKG20.54635386
99PHKG10.54635386
100MAP2K70.53963016
101TSSK60.53742700
102TYRO30.53386342
103MAP2K10.52793847
104STK30.51264432
105PAK60.51214739
106DMPK0.51083101
107BCKDK0.50018418
108PIK3CA0.49911816
109PTK2B0.48355044
110DYRK20.46352131
111ROCK10.45711281
112PAK30.44890311
113CHEK20.43916171
114PRKCZ0.43859237
115CSNK1A10.42786442
116CSF1R0.41933342
117CDK90.41766141
118TAOK20.41535242
119CHEK10.38761012
120KIT0.38513132
121RPS6KA50.38139168
122ERBB40.37976354
123MAPK130.37664880
124AKT30.37396019
125BRSK20.37281139
126NEK90.36175526
127PRKACA0.35748127
128LIMK10.35406080
129TNK20.34285899
130STK110.34201743
131MAP3K110.34121173
132PRKCI0.33511370
133SGK20.32486854
134FER0.31168155
135DYRK1A0.30920651
136CHUK0.30848206
137MAPK100.30739882
138CAMK2A0.30390467
139CDK10.29895750
140VRK10.28785606
141BLK0.28775869
142SRPK10.26622593
143SRC0.26616584
144PLK20.25838502
145MAPK90.24383427
146EIF2AK10.24278062
147CAMK1G0.22941153
148CSNK1D0.22842513
149FYN0.22029834
150MAP3K120.21392790
151PRKCD0.21259798
152ERBB30.20625450
153CDC42BPA0.20571574
154CSNK1G30.20491417
155CDK20.18578042
156CDK50.18042694
157PAK20.17975321
158EIF2AK20.17766292
159MAP3K70.17213043
160MAPKAPK20.16702934
161FGFR40.15313676
162ACVR1B0.14785818

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052176.16938032
2* Hedgehog signaling pathway_Homo sapiens_hsa043404.38646084
3DNA replication_Homo sapiens_hsa030304.32158829
4Hippo signaling pathway_Homo sapiens_hsa043903.86314916
5Notch signaling pathway_Homo sapiens_hsa043303.43913398
6Melanogenesis_Homo sapiens_hsa049162.90395342
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.89067050
8Axon guidance_Homo sapiens_hsa043602.71450197
9Wnt signaling pathway_Homo sapiens_hsa043102.70893084
10Base excision repair_Homo sapiens_hsa034102.61218880
11Phototransduction_Homo sapiens_hsa047442.53521338
12Cell cycle_Homo sapiens_hsa041102.50976985
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.49048445
14Nitrogen metabolism_Homo sapiens_hsa009102.40414112
15Linoleic acid metabolism_Homo sapiens_hsa005912.39113740
16Caffeine metabolism_Homo sapiens_hsa002322.33550133
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.29031552
18Mismatch repair_Homo sapiens_hsa034302.27754324
19Spliceosome_Homo sapiens_hsa030402.21814361
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09519875
21Ribosome_Homo sapiens_hsa030102.07660867
22Tryptophan metabolism_Homo sapiens_hsa003802.01553244
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00249652
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94465859
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89450881
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88659130
27Oxidative phosphorylation_Homo sapiens_hsa001901.85986695
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82598890
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78878241
30Histidine metabolism_Homo sapiens_hsa003401.78560844
31Butanoate metabolism_Homo sapiens_hsa006501.77208726
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74735601
33Chemical carcinogenesis_Homo sapiens_hsa052041.67091591
34Oocyte meiosis_Homo sapiens_hsa041141.64606727
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.63703947
36Protein export_Homo sapiens_hsa030601.62326614
37Homologous recombination_Homo sapiens_hsa034401.58664747
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.55218405
39MicroRNAs in cancer_Homo sapiens_hsa052061.50001747
40Parkinsons disease_Homo sapiens_hsa050121.48686830
41Ether lipid metabolism_Homo sapiens_hsa005651.46379437
42Propanoate metabolism_Homo sapiens_hsa006401.44583392
43HTLV-I infection_Homo sapiens_hsa051661.43144626
44Retinol metabolism_Homo sapiens_hsa008301.42679176
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.39440711
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.38931530
47Bladder cancer_Homo sapiens_hsa052191.37836559
48Basal transcription factors_Homo sapiens_hsa030221.35234054
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29784005
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28562499
51Fanconi anemia pathway_Homo sapiens_hsa034601.27242461
52RNA polymerase_Homo sapiens_hsa030201.23305482
53Proteoglycans in cancer_Homo sapiens_hsa052051.22662108
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16072819
55Pyrimidine metabolism_Homo sapiens_hsa002401.14912389
56mRNA surveillance pathway_Homo sapiens_hsa030151.12507235
57Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09628049
58Huntingtons disease_Homo sapiens_hsa050161.07913385
59RNA degradation_Homo sapiens_hsa030181.07451691
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06142733
61N-Glycan biosynthesis_Homo sapiens_hsa005101.03521376
62Nicotine addiction_Homo sapiens_hsa050331.03379275
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02814234
64TGF-beta signaling pathway_Homo sapiens_hsa043501.02251329
65Colorectal cancer_Homo sapiens_hsa052101.01030413
66Selenocompound metabolism_Homo sapiens_hsa004501.00160414
67* Pathways in cancer_Homo sapiens_hsa052000.99636211
68Cocaine addiction_Homo sapiens_hsa050300.93602728
69Nucleotide excision repair_Homo sapiens_hsa034200.92009048
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.91976460
71Peroxisome_Homo sapiens_hsa041460.90413546
72Cardiac muscle contraction_Homo sapiens_hsa042600.90079061
73Dorso-ventral axis formation_Homo sapiens_hsa043200.89837411
74Alzheimers disease_Homo sapiens_hsa050100.89354284
75ABC transporters_Homo sapiens_hsa020100.89052517
76Fat digestion and absorption_Homo sapiens_hsa049750.88519050
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.86815035
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86233800
79Arachidonic acid metabolism_Homo sapiens_hsa005900.83812016
80Gap junction_Homo sapiens_hsa045400.81872054
81Serotonergic synapse_Homo sapiens_hsa047260.81000287
82p53 signaling pathway_Homo sapiens_hsa041150.77127578
83Glycerolipid metabolism_Homo sapiens_hsa005610.76426014
84One carbon pool by folate_Homo sapiens_hsa006700.75271385
85beta-Alanine metabolism_Homo sapiens_hsa004100.74371418
86Synaptic vesicle cycle_Homo sapiens_hsa047210.71137416
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71092322
88Ovarian steroidogenesis_Homo sapiens_hsa049130.70393788
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70254115
90Alcoholism_Homo sapiens_hsa050340.69424578
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69319792
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68988528
93Steroid biosynthesis_Homo sapiens_hsa001000.68697242
94Prion diseases_Homo sapiens_hsa050200.68483381
95RNA transport_Homo sapiens_hsa030130.66964044
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65877434
97Vibrio cholerae infection_Homo sapiens_hsa051100.64893930
98Insulin secretion_Homo sapiens_hsa049110.63624103
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60982612
100Circadian entrainment_Homo sapiens_hsa047130.60590851
101Dopaminergic synapse_Homo sapiens_hsa047280.59762028
102Purine metabolism_Homo sapiens_hsa002300.57930973
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57621008
104Renal cell carcinoma_Homo sapiens_hsa052110.57586164
105Systemic lupus erythematosus_Homo sapiens_hsa053220.57089713
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55249367
107Melanoma_Homo sapiens_hsa052180.53887254
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51701612
109Glioma_Homo sapiens_hsa052140.50519775
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.50181202
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49479138
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49145541
113ECM-receptor interaction_Homo sapiens_hsa045120.48653716
114Vitamin digestion and absorption_Homo sapiens_hsa049770.47163860
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46819784
116Regulation of autophagy_Homo sapiens_hsa041400.46619925
117Metabolic pathways_Homo sapiens_hsa011000.46302961
118Chronic myeloid leukemia_Homo sapiens_hsa052200.46219721
119Viral carcinogenesis_Homo sapiens_hsa052030.45646987
120Pancreatic cancer_Homo sapiens_hsa052120.44940721
121GABAergic synapse_Homo sapiens_hsa047270.43838578
122Amphetamine addiction_Homo sapiens_hsa050310.42406539
123Small cell lung cancer_Homo sapiens_hsa052220.41480407
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41243339
125Folate biosynthesis_Homo sapiens_hsa007900.40877398
126Type II diabetes mellitus_Homo sapiens_hsa049300.40395255
127Salivary secretion_Homo sapiens_hsa049700.40110770
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.40068147
129Adherens junction_Homo sapiens_hsa045200.39126120
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38527586
131Phagosome_Homo sapiens_hsa041450.38332583
132Primary immunodeficiency_Homo sapiens_hsa053400.37984397
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36098839
134Glutamatergic synapse_Homo sapiens_hsa047240.36069269
135Starch and sucrose metabolism_Homo sapiens_hsa005000.35864602
136Biosynthesis of amino acids_Homo sapiens_hsa012300.35537120
137Non-homologous end-joining_Homo sapiens_hsa034500.35504704
138Collecting duct acid secretion_Homo sapiens_hsa049660.35369013
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34837692
140Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34596316
141Tight junction_Homo sapiens_hsa045300.34048377
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33421173
143Phenylalanine metabolism_Homo sapiens_hsa003600.32180898
144Bile secretion_Homo sapiens_hsa049760.30601131
145Sulfur metabolism_Homo sapiens_hsa009200.30097043
146cAMP signaling pathway_Homo sapiens_hsa040240.29658258
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29440433
148Mineral absorption_Homo sapiens_hsa049780.28650959
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28558668
150Fatty acid biosynthesis_Homo sapiens_hsa000610.28255968
151Hepatitis B_Homo sapiens_hsa051610.27895262
152Rap1 signaling pathway_Homo sapiens_hsa040150.27799519
153Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27408679
154ErbB signaling pathway_Homo sapiens_hsa040120.27399090
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25656662
156AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25512501
157Long-term depression_Homo sapiens_hsa047300.24995621
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24991483
159Tyrosine metabolism_Homo sapiens_hsa003500.24207975
160Taste transduction_Homo sapiens_hsa047420.22738865
161Endometrial cancer_Homo sapiens_hsa052130.22495086
162Thyroid hormone synthesis_Homo sapiens_hsa049180.20096153
163Morphine addiction_Homo sapiens_hsa050320.18884129
164Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18298754
165Lysine degradation_Homo sapiens_hsa003100.18100020
166Focal adhesion_Homo sapiens_hsa045100.18008108
167Fatty acid elongation_Homo sapiens_hsa000620.17791170
168Arginine and proline metabolism_Homo sapiens_hsa003300.17372993
169AMPK signaling pathway_Homo sapiens_hsa041520.17290913
170Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15820749
171Non-small cell lung cancer_Homo sapiens_hsa052230.14958171
172Olfactory transduction_Homo sapiens_hsa047400.14721700

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