SHCBP1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Src homology 2 domain-binding protein 1-like protein. The encoded protein interacts with heat shock 70 kDa protein 2 and may be involved in maintaining spindle integrity during meiosis. This gene is located in region of chromoso0me 1 encompassing a prostate cancer susceptibility locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.78757475
2sperm-egg recognition (GO:0035036)9.69110365
3acrosome assembly (GO:0001675)9.55032329
4synaptonemal complex organization (GO:0070193)9.39754478
5epithelial cilium movement (GO:0003351)9.32537304
6binding of sperm to zona pellucida (GO:0007339)9.11839341
7DNA methylation involved in gamete generation (GO:0043046)9.04493555
8motile cilium assembly (GO:0044458)9.04455337
9acrosome reaction (GO:0007340)8.95686013
10synaptonemal complex assembly (GO:0007130)8.84303694
11plasma membrane fusion (GO:0045026)8.83841664
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.79420955
13cell-cell recognition (GO:0009988)8.67193766
14spermatid development (GO:0007286)8.56824792
15cilium movement (GO:0003341)8.24011543
16reciprocal DNA recombination (GO:0035825)8.06305546
17reciprocal meiotic recombination (GO:0007131)8.06305546
18reproduction (GO:0000003)7.82664213
19male meiosis I (GO:0007141)7.47083145
20regulation of cilium movement (GO:0003352)6.82866470
21cell wall macromolecule catabolic process (GO:0016998)6.79324394
22cell wall macromolecule metabolic process (GO:0044036)6.79324394
23single fertilization (GO:0007338)6.60115567
24chromosome organization involved in meiosis (GO:0070192)6.43988269
25resolution of meiotic recombination intermediates (GO:0000712)6.28381930
26meiotic nuclear division (GO:0007126)6.19301644
27meiosis I (GO:0007127)6.04949196
28fertilization (GO:0009566)6.00785793
29negative regulation of inclusion body assembly (GO:0090084)5.86715044
30sperm capacitation (GO:0048240)5.58701325
31spermatogenesis (GO:0007283)5.47425372
32male gamete generation (GO:0048232)5.45521799
33meiotic cell cycle (GO:0051321)5.44973736
34seminiferous tubule development (GO:0072520)5.29606546
35germ cell development (GO:0007281)5.25143170
36ventricular system development (GO:0021591)5.23746214
37protein localization to cilium (GO:0061512)5.20402343
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.03671634
39gamete generation (GO:0007276)5.02520701
40positive regulation of meiosis (GO:0045836)4.99877885
41gene silencing by RNA (GO:0031047)4.69083728
42positive regulation of meiotic cell cycle (GO:0051446)4.68100847
43regulation of meiosis I (GO:0060631)4.64470149
44regulation of inclusion body assembly (GO:0090083)4.51003775
45intraciliary transport (GO:0042073)4.48337491
46female gamete generation (GO:0007292)4.41805324
47histone H3-K9 demethylation (GO:0033169)4.32747429
48microtubule depolymerization (GO:0007019)4.29524154
49cell recognition (GO:0008037)4.29064634
50protein localization to chromosome (GO:0034502)4.20479229
51meiotic cell cycle process (GO:1903046)4.11603806
52regulation of meiotic cell cycle (GO:0051445)4.10349194
53left/right pattern formation (GO:0060972)4.09926668
54synapsis (GO:0007129)4.08132094
55calcium ion-dependent exocytosis (GO:0017156)4.06839104
56meiotic chromosome segregation (GO:0045132)4.02461450
57microtubule severing (GO:0051013)4.01269788
58organic cation transport (GO:0015695)3.93010723
59multicellular organismal reproductive process (GO:0048609)3.88763023
60reproductive system development (GO:0061458)3.85461195
61genitalia morphogenesis (GO:0035112)3.83032073
62monoubiquitinated protein deubiquitination (GO:0035520)3.78466013
63regulation of microtubule-based movement (GO:0060632)3.78272317
64DNA biosynthetic process (GO:0071897)3.77234644
65DNA alkylation (GO:0006305)3.73559549
66DNA methylation (GO:0006306)3.73559549
67regulation of protein polyubiquitination (GO:1902914)3.62234316
68axoneme assembly (GO:0035082)3.61951976
69nuclear pore complex assembly (GO:0051292)3.58636297
70histone H2A acetylation (GO:0043968)3.54673518
71regulation of centriole replication (GO:0046599)3.52854879
72centriole replication (GO:0007099)3.41157203
73regulation of DNA endoreduplication (GO:0032875)3.40929135
74lactate metabolic process (GO:0006089)3.37835699
75protein polyglutamylation (GO:0018095)3.37555031
76histone H3-K36 demethylation (GO:0070544)3.37098186
77striatum development (GO:0021756)3.35048961
78retinal cone cell development (GO:0046549)3.34943115
79microtubule-based movement (GO:0007018)3.34254678
80chromosome organization (GO:0051276)3.28018420
81centriole assembly (GO:0098534)3.25716425
82cilium organization (GO:0044782)3.22479327
83negative regulation of DNA repair (GO:0045738)3.15317579
84multicellular organismal development (GO:0007275)3.15022560
85negative regulation of organelle assembly (GO:1902116)3.14938391
86mitotic sister chromatid cohesion (GO:0007064)3.10397212
87gene silencing (GO:0016458)3.09029689
88translesion synthesis (GO:0019985)3.04993811
89cilium assembly (GO:0042384)3.04840606
90sister chromatid cohesion (GO:0007062)3.02833614
91nuclear pore organization (GO:0006999)3.01758147
92positive regulation of cellular response to oxidative stress (GO:1900409)3.01000016
93positive regulation of response to oxidative stress (GO:1902884)3.01000016
94cilium morphogenesis (GO:0060271)2.98807059
95negative regulation of gene silencing (GO:0060969)2.96007440
96DNA methylation or demethylation (GO:0044728)2.92173428
97attachment of spindle microtubules to kinetochore (GO:0008608)2.89784948
98nonmotile primary cilium assembly (GO:0035058)2.88123815
99pore complex assembly (GO:0046931)2.87131526
100cellular component assembly involved in morphogenesis (GO:0010927)2.85266053
101spermatid nucleus differentiation (GO:0007289)2.84977591
102regulation of chromatin binding (GO:0035561)2.84672342
103chaperone-mediated protein complex assembly (GO:0051131)2.83493985
104regulation of spindle checkpoint (GO:0090231)2.83127531
105protein refolding (GO:0042026)2.83046176
106sex differentiation (GO:0007548)2.82387034
107histone H4-K12 acetylation (GO:0043983)2.80814428
108alditol metabolic process (GO:0019400)2.77001967
109photoreceptor cell maintenance (GO:0045494)2.76356515
110polyol catabolic process (GO:0046174)2.75040814
111regulation of meiosis (GO:0040020)2.73626346
112DNA modification (GO:0006304)2.73007407
113carnitine transmembrane transport (GO:1902603)2.71999374
114regulation of double-strand break repair via homologous recombination (GO:0010569)2.70359726
115negative regulation of appetite (GO:0032099)2.69145780
116negative regulation of response to food (GO:0032096)2.69145780
117nucleoside diphosphate phosphorylation (GO:0006165)2.66041460
118carnitine transport (GO:0015879)2.65422874
119amino-acid betaine transport (GO:0015838)2.65422874
120histone exchange (GO:0043486)2.64835344
121cellular response to gamma radiation (GO:0071480)2.63183149
122peptidyl-threonine dephosphorylation (GO:0035970)2.63152369
123nuclear division (GO:0000280)2.63126970
124regulation of histone H3-K9 methylation (GO:0051570)2.61295202
125nucleus organization (GO:0006997)2.60236798
126oogenesis (GO:0048477)2.58145318
127behavioral response to nicotine (GO:0035095)2.56211464
128regulation of response to food (GO:0032095)2.56021342
129regulation of transcription from RNA polymerase I promoter (GO:0006356)2.55481751
130DNA packaging (GO:0006323)2.50444876
131DNA catabolic process, exonucleolytic (GO:0000738)2.48525245
132histone H4-K16 acetylation (GO:0043984)2.46933607
133regulation of double-strand break repair (GO:2000779)2.46116925
134detection of light stimulus involved in visual perception (GO:0050908)2.42360295
135detection of light stimulus involved in sensory perception (GO:0050962)2.42360295
136organelle fission (GO:0048285)2.41824596
137tongue development (GO:0043586)2.40641067
138interkinetic nuclear migration (GO:0022027)2.38545875
139histone lysine demethylation (GO:0070076)2.35870187
140left/right axis specification (GO:0070986)2.35149939
141regulation of collateral sprouting (GO:0048670)2.32840157
142response to pheromone (GO:0019236)2.30851846
143histone demethylation (GO:0016577)2.28274643
144DNA recombination (GO:0006310)2.25770905
145cilium or flagellum-dependent cell motility (GO:0001539)16.3739799
146DNA synthesis involved in DNA repair (GO:0000731)13.7274237
147piRNA metabolic process (GO:0034587)12.9845584
148fusion of sperm to egg plasma membrane (GO:0007342)11.6343780
149sperm motility (GO:0030317)10.6440389
150male meiosis (GO:0007140)10.5993476
151axonemal dynein complex assembly (GO:0070286)10.5141620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.32745487
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.24014897
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.90219426
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.84907834
5BMI1_23680149_ChIP-Seq_NPCS_Mouse3.43653209
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.30491041
7FLI1_27457419_Chip-Seq_LIVER_Mouse3.00301771
8IGF1R_20145208_ChIP-Seq_DFB_Human2.88513953
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.60814450
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32938726
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27881275
12RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.19539065
13ZNF274_21170338_ChIP-Seq_K562_Hela2.06624193
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03729201
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.7917177
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97928806
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.94498946
18NFE2_27457419_Chip-Seq_LIVER_Mouse1.88978039
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88969252
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.88063342
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82369253
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77938112
23VDR_22108803_ChIP-Seq_LS180_Human1.77674077
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.77382793
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.75484054
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75079423
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.71198766
28AR_25329375_ChIP-Seq_VCAP_Human1.67080280
29MYC_18940864_ChIP-ChIP_HL60_Human1.61348374
30ERA_21632823_ChIP-Seq_H3396_Human1.58617250
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55385788
32P300_19829295_ChIP-Seq_ESCs_Human1.54824591
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52990638
34RUNX2_22187159_ChIP-Seq_PCA_Human1.52525501
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.52308435
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50448757
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.49947803
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47818880
39FOXA1_21572438_ChIP-Seq_LNCaP_Human1.47693856
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47084360
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45424826
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45227359
43TAL1_26923725_Chip-Seq_HPCs_Mouse1.44464413
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.42672153
45PRDM14_20953172_ChIP-Seq_ESCs_Human1.39825162
46RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39710237
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.39097656
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38443968
49KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.38084913
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.37815726
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37815726
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37341286
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35045166
54EWS_26573619_Chip-Seq_HEK293_Human1.34941903
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.34813565
56STAT1_17558387_ChIP-Seq_HELA_Human1.33193586
57TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.32667562
58TAF15_26573619_Chip-Seq_HEK293_Human1.32280890
59STAT3_18555785_Chip-Seq_ESCs_Mouse1.32126207
60P53_22387025_ChIP-Seq_ESCs_Mouse1.32113079
61STAT3_23295773_ChIP-Seq_U87_Human1.30324763
62OCT4_18555785_Chip-Seq_ESCs_Mouse1.29859072
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29849304
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29849304
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29849304
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29528126
67P300_18555785_Chip-Seq_ESCs_Mouse1.29433042
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29075470
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29027669
70KAP1_22055183_ChIP-Seq_ESCs_Mouse1.28286654
71KDM2B_26808549_Chip-Seq_REH_Human1.27482369
72E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25981416
73HOXB7_26014856_ChIP-Seq_BT474_Human1.25898314
74CBP_20019798_ChIP-Seq_JUKART_Human1.25425728
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25425728
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23495081
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.23086543
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23068148
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22108615
80RNF2_27304074_Chip-Seq_NSC_Mouse1.21731315
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21605909
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.21495475
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.21425750
84KLF4_18555785_Chip-Seq_ESCs_Mouse1.21329929
85JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20238559
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19540060
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19539737
88REST_21632747_ChIP-Seq_MESCs_Mouse1.19471526
89RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19259186
90MYC_19829295_ChIP-Seq_ESCs_Human1.18197872
91TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.17689706
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17613153
93ER_23166858_ChIP-Seq_MCF-7_Human1.16862476
94ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16695334
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15973019
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.15959368
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15533383
98TCF4_22108803_ChIP-Seq_LS180_Human1.13149382
99OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12696712
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12227520
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12227520
102PU1_27457419_Chip-Seq_LIVER_Mouse1.12114188
103TCF4_23295773_ChIP-Seq_U87_Human1.11488620
104GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.11184641
105AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10890233
106FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10717829
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09456866
108FOXH1_21741376_ChIP-Seq_EPCs_Human1.08412548
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08268318
110GATA3_21867929_ChIP-Seq_CD8_Mouse1.07722849
111TP63_19390658_ChIP-ChIP_HaCaT_Human1.07604471
112EED_16625203_ChIP-ChIP_MESCs_Mouse1.07272312
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07217248
114NCOR_22424771_ChIP-Seq_293T_Human1.06396273
115AR_20517297_ChIP-Seq_VCAP_Human1.06138678
116SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04900109
117RNF2_27304074_Chip-Seq_ESCs_Mouse1.03392207
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03354891
119ZFX_18555785_Chip-Seq_ESCs_Mouse1.03192175
120CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02962968
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.02484724
122SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.00547843
123NANOG_19829295_ChIP-Seq_ESCs_Human1.00515891
124SOX2_19829295_ChIP-Seq_ESCs_Human1.00515891
125NMYC_18555785_Chip-Seq_ESCs_Mouse1.00123562
126CTCF_18555785_Chip-Seq_ESCs_Mouse0.99934252
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99894221
128SOX2_22085726_ChIP-Seq_NPCs_Mouse0.99421199
129FLI1_21867929_ChIP-Seq_TH2_Mouse0.99216252
130FUS_26573619_Chip-Seq_HEK293_Human0.99084891
131ETV1_20927104_ChIP-Seq_GIST48_Human0.98837017
132SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98240570
133GBX2_23144817_ChIP-Seq_PC3_Human0.98213989
134BCAT_22108803_ChIP-Seq_LS180_Human0.97678346
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96438574
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96315641
137HTT_18923047_ChIP-ChIP_STHdh_Human0.95648650
138RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95463797
139GATA3_21867929_ChIP-Seq_TH1_Mouse0.95142667
140ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95057952
141GATA3_21878914_ChIP-Seq_MCF-7_Human0.93874329
142RAC3_21632823_ChIP-Seq_H3396_Human0.93270638
143GABP_17652178_ChIP-ChIP_JURKAT_Human0.92777140
144NOTCH1_21737748_ChIP-Seq_TLL_Human0.92065417
145P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91868360
146CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90767617
147SMAD4_21799915_ChIP-Seq_A2780_Human0.90635388
148SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90266666
149GF1_26923725_Chip-Seq_HPCs_Mouse0.89820760
150PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88732759
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86486703
152CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85880515
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.84754620
154TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84500803
155RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84197406
156EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83878981
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83875918
158TP53_22573176_ChIP-Seq_HFKS_Human0.83129010
159FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83056507
160SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81827407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.33737282
2MP0003698_abnormal_male_reproductive5.56787714
3MP0001929_abnormal_gametogenesis5.32988629
4MP0002210_abnormal_sex_determination4.11535725
5MP0008057_abnormal_DNA_replication3.40176356
6MP0001145_abnormal_male_reproductive3.34406424
7MP0000383_abnormal_hair_follicle3.33136432
8MP0002161_abnormal_fertility/fecundity3.00619693
9MP0000653_abnormal_sex_gland2.94027588
10MP0002653_abnormal_ependyma_morphology2.74411983
11MP0010678_abnormal_skin_adnexa2.21105793
12MP0002160_abnormal_reproductive_system2.16754267
13MP0003123_paternal_imprinting2.13498306
14MP0008058_abnormal_DNA_repair2.04532461
15MP0010094_abnormal_chromosome_stability2.01568559
16MP0005410_abnormal_fertilization12.9345027
17MP0000579_abnormal_nail_morphology1.92592807
18MP0008004_abnormal_stomach_pH1.81200126
19MP0003718_maternal_effect1.78342901
20MP0005623_abnormal_meninges_morphology1.67479119
21MP0001501_abnormal_sleep_pattern1.64915309
22MP0002095_abnormal_skin_pigmentation1.62475919
23MP0003786_premature_aging1.56257166
24MP0008007_abnormal_cellular_replicative1.52102666
25MP0005275_abnormal_skin_tensile1.47773661
26MP0010030_abnormal_orbit_morphology1.45870126
27MP0003136_yellow_coat_color1.44013428
28MP0008995_early_reproductive_senescence1.39119453
29MP0005670_abnormal_white_adipose1.30560280
30MP0005647_abnormal_sex_gland1.30070859
31MP0009046_muscle_twitch1.29721375
32MP0001984_abnormal_olfaction1.27029755
33MP0003646_muscle_fatigue1.26950530
34MP0002249_abnormal_larynx_morphology1.24353619
35MP0003111_abnormal_nucleus_morphology1.20691867
36MP0004742_abnormal_vestibular_system1.19594055
37MP0005389_reproductive_system_phenotype1.15574256
38MP0004134_abnormal_chest_morphology1.15178899
39MP0000569_abnormal_digit_pigmentation1.14015331
40MP0004043_abnormal_pH_regulation1.13372206
41MP0003011_delayed_dark_adaptation1.06654938
42MP0008789_abnormal_olfactory_epithelium1.04544767
43MP0002736_abnormal_nociception_after1.02752556
44MP0001485_abnormal_pinna_reflex0.98093226
45MP0003121_genomic_imprinting0.97782488
46MP0001502_abnormal_circadian_rhythm0.97628047
47MP0004808_abnormal_hematopoietic_stem0.95192748
48MP0003937_abnormal_limbs/digits/tail_de0.93918716
49MP0000678_abnormal_parathyroid_gland0.93545877
50MP0001919_abnormal_reproductive_system0.93492993
51MP0006276_abnormal_autonomic_nervous0.93403871
52MP0001486_abnormal_startle_reflex0.93262413
53MP0000631_abnormal_neuroendocrine_gland0.92038893
54MP0002282_abnormal_trachea_morphology0.88336812
55MP0009250_abnormal_appendicular_skeleto0.83578386
56MP0001661_extended_life_span0.82528351
57MP0005310_abnormal_salivary_gland0.81877030
58MP0002102_abnormal_ear_morphology0.80961185
59MP0003119_abnormal_digestive_system0.76479838
60MP0005386_behavior/neurological_phenoty0.76036931
61MP0004924_abnormal_behavior0.76036931
62MP0000566_synostosis0.75652002
63MP0001119_abnormal_female_reproductive0.75287095
64MP0002139_abnormal_hepatobiliary_system0.74129384
65MP0000015_abnormal_ear_pigmentation0.73318318
66MP0003077_abnormal_cell_cycle0.72000671
67MP0004233_abnormal_muscle_weight0.71344425
68MP0001529_abnormal_vocalization0.69387556
69MP0001968_abnormal_touch/_nociception0.68939667
70MP0003880_abnormal_central_pattern0.67615654
71MP0004133_heterotaxia0.66613865
72MP0009703_decreased_birth_body0.66059116
73MP0006292_abnormal_olfactory_placode0.65792600
74MP0002876_abnormal_thyroid_physiology0.64901602
75MP0005499_abnormal_olfactory_system0.64509454
76MP0005394_taste/olfaction_phenotype0.64509454
77MP0002557_abnormal_social/conspecific_i0.64381870
78MP0002234_abnormal_pharynx_morphology0.63762649
79MP0002184_abnormal_innervation0.62932092
80MP0004142_abnormal_muscle_tone0.62869246
81MP0010307_abnormal_tumor_latency0.62519982
82MP0001545_abnormal_hematopoietic_system0.61736103
83MP0005397_hematopoietic_system_phenotyp0.61736103
84MP0003699_abnormal_female_reproductive0.61452119
85MP0001765_abnormal_ion_homeostasis0.60270182
86MP0003938_abnormal_ear_development0.58931226
87MP0002735_abnormal_chemical_nociception0.58298441
88MP0000049_abnormal_middle_ear0.58078943
89MP0005377_hearing/vestibular/ear_phenot0.57984567
90MP0003878_abnormal_ear_physiology0.57984567
91MP0005646_abnormal_pituitary_gland0.55781747
92MP0004885_abnormal_endolymph0.54378271
93MP0010386_abnormal_urinary_bladder0.54206042
94MP0002822_catalepsy0.53884718
95MP0001851_eye_inflammation0.53653819
96MP0000358_abnormal_cell_content/0.52976363
97MP0001970_abnormal_pain_threshold0.52891845
98MP0005174_abnormal_tail_pigmentation0.51975495
99MP0002938_white_spotting0.51855172
100MP0003879_abnormal_hair_cell0.50906864
101MP0003787_abnormal_imprinting0.50650119
102MP0000013_abnormal_adipose_tissue0.50504478
103MP0002572_abnormal_emotion/affect_behav0.48513532
104MP0001727_abnormal_embryo_implantation0.47319646
105MP0003693_abnormal_embryo_hatching0.46952899
106MP0009745_abnormal_behavioral_response0.45060406
107MP0005551_abnormal_eye_electrophysiolog0.44419241
108MP0002272_abnormal_nervous_system0.42849257
109MP0002928_abnormal_bile_duct0.42597521
110MP0003763_abnormal_thymus_physiology0.42073970
111MP0003045_fibrosis0.41794549
112MP0000313_abnormal_cell_death0.41545612
113MP0002638_abnormal_pupillary_reflex0.41461459
114MP0001293_anophthalmia0.41345666
115MP0005253_abnormal_eye_physiology0.39971819
116MP0001440_abnormal_grooming_behavior0.38838099
117MP0000647_abnormal_sebaceous_gland0.38263691
118MP0000955_abnormal_spinal_cord0.37713712
119MP0001986_abnormal_taste_sensitivity0.37345949
120MP0003861_abnormal_nervous_system0.36982200
121MP0003115_abnormal_respiratory_system0.35910396
122MP0002063_abnormal_learning/memory/cond0.35829618
123MP0006035_abnormal_mitochondrial_morpho0.35717511
124MP0005423_abnormal_somatic_nervous0.35710307
125MP0005391_vision/eye_phenotype0.35635494
126MP0002067_abnormal_sensory_capabilities0.35421961
127MP0001324_abnormal_eye_pigmentation0.34971245
128MP0003635_abnormal_synaptic_transmissio0.34927535
129MP0002152_abnormal_brain_morphology0.34790405
130MP0000778_abnormal_nervous_system0.34506833
131MP0002229_neurodegeneration0.32790053
132MP0009278_abnormal_bone_marrow0.31777489
133MP0008932_abnormal_embryonic_tissue0.31333184
134MP0004811_abnormal_neuron_physiology0.30018522
135MP0000427_abnormal_hair_cycle0.29731309
136MP0005409_darkened_coat_color0.29302267
137MP0005171_absent_coat_pigmentation0.28966702
138MP0009697_abnormal_copulation0.28902217
139MP0002064_seizures0.26918184
140MP0003936_abnormal_reproductive_system0.26652009
141MP0004859_abnormal_synaptic_plasticity0.24429425
142MP0001963_abnormal_hearing_physiology0.22728467
143MP0002233_abnormal_nose_morphology0.21749126
144MP0001835_abnormal_antigen_presentation0.21606381
145MP0003631_nervous_system_phenotype0.21493854
146MP0000920_abnormal_myelination0.21482687

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.69019431
2Abnormal respiratory motile cilium morphology (HP:0005938)8.21405786
3Abnormal respiratory epithelium morphology (HP:0012253)8.21405786
4Rhinitis (HP:0012384)7.58329827
5Oligodactyly (hands) (HP:0001180)7.12050711
6Abnormal ciliary motility (HP:0012262)6.91669260
7Chronic bronchitis (HP:0004469)6.64001966
8Volvulus (HP:0002580)5.88763775
9Nasal polyposis (HP:0100582)5.66539681
10Infertility (HP:0000789)5.65947980
11Shoulder girdle muscle weakness (HP:0003547)5.18820413
12Nephronophthisis (HP:0000090)5.01924045
13Oligodactyly (HP:0012165)4.90721970
14Rimmed vacuoles (HP:0003805)4.84778437
15Degeneration of the lateral corticospinal tracts (HP:0002314)4.77725517
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.77725517
17Abnormality of the lower motor neuron (HP:0002366)4.62060269
18Abnormality of the nasal mucosa (HP:0000433)4.55124670
19Bronchiectasis (HP:0002110)4.36865772
20Follicular hyperkeratosis (HP:0007502)4.10698374
21Congenital, generalized hypertrichosis (HP:0004540)4.09114025
22Bronchitis (HP:0012387)4.06561848
23Pili torti (HP:0003777)3.88605227
24Abnormality of the renal medulla (HP:0100957)3.87739015
25Abnormality of the corticospinal tract (HP:0002492)3.74164334
26Gonadotropin excess (HP:0000837)3.67736055
27Spontaneous abortion (HP:0005268)3.55554706
28Tubulointerstitial nephritis (HP:0001970)3.54256818
29Amyotrophic lateral sclerosis (HP:0007354)3.49558410
30Fibular hypoplasia (HP:0003038)3.18084300
31Aplasia/Hypoplasia of the sternum (HP:0006714)3.15133716
32Recurrent otitis media (HP:0000403)3.06930012
33Recurrent sinusitis (HP:0011108)3.01305918
34Upper motor neuron abnormality (HP:0002127)3.00610835
35Abnormality of midbrain morphology (HP:0002418)2.92016423
36Molar tooth sign on MRI (HP:0002419)2.92016423
37Congenital stationary night blindness (HP:0007642)2.89473910
38Abnormal spermatogenesis (HP:0008669)2.88376112
39Medial flaring of the eyebrow (HP:0010747)2.88030025
40Capillary hemangiomas (HP:0005306)2.87718018
41Impaired proprioception (HP:0010831)2.87517542
42Fair hair (HP:0002286)2.79081203
43Tubular atrophy (HP:0000092)2.77267544
44Facial hemangioma (HP:0000329)2.76708628
45Abnormality of the anterior horn cell (HP:0006802)2.75753531
46Degeneration of anterior horn cells (HP:0002398)2.75753531
47Tubulointerstitial abnormality (HP:0001969)2.72829839
48Male infertility (HP:0003251)2.68317475
49Increased nuchal translucency (HP:0010880)2.62193878
50Postaxial foot polydactyly (HP:0001830)2.59473213
51Abnormality of the labia minora (HP:0012880)2.58362623
5211 pairs of ribs (HP:0000878)2.57439461
53Hypoplastic labia majora (HP:0000059)2.57083723
54Abnormality of alanine metabolism (HP:0010916)2.55633389
55Hyperalaninemia (HP:0003348)2.55633389
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55633389
57Azoospermia (HP:0000027)2.49425346
58Protruding tongue (HP:0010808)2.48653431
59Truncal obesity (HP:0001956)2.46793860
60Hypoplasia of the capital femoral epiphysis (HP:0003090)2.42059347
61Impaired vibration sensation in the lower limbs (HP:0002166)2.35860526
62Recurrent bronchitis (HP:0002837)2.34935103
63Abnormality of the labia majora (HP:0012881)2.32094808
64Aplasia/Hypoplasia of the fibula (HP:0006492)2.27546575
65Impulsivity (HP:0100710)2.27314754
66Non-midline cleft lip (HP:0100335)2.26625357
67Stage 5 chronic kidney disease (HP:0003774)2.22610067
68Congenital hepatic fibrosis (HP:0002612)2.17035044
69Limb-girdle muscle weakness (HP:0003325)2.16775447
70Abnormality of the renal cortex (HP:0011035)2.12494173
71Optic nerve coloboma (HP:0000588)2.11724313
72Widely spaced teeth (HP:0000687)2.10665482
73Small intestinal stenosis (HP:0012848)2.09005907
74Duodenal stenosis (HP:0100867)2.09005907
75Multicystic kidney dysplasia (HP:0000003)2.08669770
76Supernumerary spleens (HP:0009799)2.07375619
77Hypoplasia of the radius (HP:0002984)2.04551162
78Generalized hypopigmentation of hair (HP:0011358)2.03828857
79Oculomotor apraxia (HP:0000657)2.02575061
80Retinal dysplasia (HP:0007973)2.02137080
81Absent frontal sinuses (HP:0002688)2.01664866
82Abnormal hair laboratory examination (HP:0003328)2.00135997
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8533363
84Dynein arm defect of respiratory motile cilia (HP:0012255)11.5301898
85Absent/shortened dynein arms (HP:0200106)11.5301898
86Genital tract atresia (HP:0001827)1.99330221
87Horizontal nystagmus (HP:0000666)1.99306061
88Abnormality of hair growth rate (HP:0011363)1.97639828
89Slow-growing hair (HP:0002217)1.97639828
90Urinary bladder sphincter dysfunction (HP:0002839)1.97231551
91Proximal placement of thumb (HP:0009623)1.96401953
92Short ribs (HP:0000773)1.94232545
93Hyperglycinemia (HP:0002154)1.93738913
94Tubulointerstitial fibrosis (HP:0005576)1.93544011
95Occipital encephalocele (HP:0002085)1.92999821
96Spastic gait (HP:0002064)1.92808432
97Optic nerve hypoplasia (HP:0000609)1.92772755
98Urinary urgency (HP:0000012)1.91962565
99Conjunctival telangiectasia (HP:0000524)1.90521491
100Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89904265
101Absent epiphyses (HP:0010577)1.89904265
102Abnormality of the vocal cords (HP:0008777)1.89838775
103Vaginal atresia (HP:0000148)1.87601631
104Postaxial hand polydactyly (HP:0001162)1.87135160
105Renal dysplasia (HP:0000110)1.85697605
106Abnormal drinking behavior (HP:0030082)1.83797938
107Polydipsia (HP:0001959)1.83797938
108Astigmatism (HP:0000483)1.83794871
109Morphological abnormality of the pyramidal tract (HP:0002062)1.83345104
110Abnormality of the dental root (HP:0006486)1.83256623
111Taurodontia (HP:0000679)1.83256623
112Abnormality of permanent molar morphology (HP:0011071)1.83256623
113Pancreatic cysts (HP:0001737)1.83021805
114Abnormality of the labia (HP:0000058)1.81270276
115Scotoma (HP:0000575)1.80191675
116Median cleft lip (HP:0000161)1.79339268
117Gaze-evoked nystagmus (HP:0000640)1.79319726
118Abnormality of dentin (HP:0010299)1.79187449
119Brittle hair (HP:0002299)1.78519581
120Abnormality of serine family amino acid metabolism (HP:0010894)1.77952097
121Abnormality of glycine metabolism (HP:0010895)1.77952097
122Small hand (HP:0200055)1.77603830
123Weak cry (HP:0001612)1.77189957
124Abnormality of chromosome stability (HP:0003220)1.75911519
125Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75799517
126Birth length less than 3rd percentile (HP:0003561)1.75747086
127Chronic sinusitis (HP:0011109)1.75272674
128Osteomalacia (HP:0002749)1.74151513
129Abnormal lung lobation (HP:0002101)1.74133032
130Facial cleft (HP:0002006)1.73353152
131Maternal diabetes (HP:0009800)1.72322807
132Large eyes (HP:0001090)1.72090197
133Drooling (HP:0002307)1.71670299
134Delayed CNS myelination (HP:0002188)1.71547412
135Abnormality of molar (HP:0011077)1.70863887
136Abnormality of molar morphology (HP:0011070)1.70863887
137Abnormality of the duodenum (HP:0002246)1.70817904
138J-shaped sella turcica (HP:0002680)1.69076494
139Selective tooth agenesis (HP:0001592)1.67435985
140Short thorax (HP:0010306)1.66904218
141Cerebellar dysplasia (HP:0007033)1.64217841
142Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63557055
143Pancreatic fibrosis (HP:0100732)1.61875075
144Congenital primary aphakia (HP:0007707)1.61000850
145Breast carcinoma (HP:0003002)1.60638593
146Abnormality of the dental pulp (HP:0006479)1.58987695
147Broad distal phalanx of finger (HP:0009836)1.58966625
148Gait imbalance (HP:0002141)1.58620974
149Decreased motor nerve conduction velocity (HP:0003431)1.57854288
150Microglossia (HP:0000171)1.56805696
151Bell-shaped thorax (HP:0001591)1.55975922
152True hermaphroditism (HP:0010459)1.53666554
153Cystic liver disease (HP:0006706)1.53288910
154Nephropathy (HP:0000112)1.53001420
155Ectopic kidney (HP:0000086)1.52965695
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.52789179
157Abnormality of the vasculature of the conjunctiva (HP:0008054)1.48875532
158Nephrogenic diabetes insipidus (HP:0009806)1.45719886
159Type II lissencephaly (HP:0007260)1.44711850
160Chronic hepatic failure (HP:0100626)1.44142536
161Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.42227361
162Chromosomal breakage induced by crosslinking agents (HP:0003221)1.41578781
163Pachygyria (HP:0001302)1.40599935
164Sloping forehead (HP:0000340)1.40238188
165Spastic tetraparesis (HP:0001285)1.39623752
166Atrophy/Degeneration involving motor neurons (HP:0007373)1.38799195
167Poor coordination (HP:0002370)1.37897351
168Abnormality of ocular smooth pursuit (HP:0000617)1.37009340
169Short femoral neck (HP:0100864)1.36986477
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.34985567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.25618445
2PDK49.25618445
3PDK26.02788749
4CDK193.70242763
5TESK13.30632975
6PRKD32.47256499
7PTK2B2.46963419
8PNCK2.29292769
9ICK2.27600957
10STK392.21125079
11WNK42.02151761
12NEK21.98024439
13TLK11.95989352
14ACVR1B1.91491792
15NEK91.66489631
16MET1.66016226
17CDC71.64868068
18MAP4K21.50311669
19PASK1.44291422
20CCNB11.26315242
21MOS1.21145509
22WNK11.13082213
23STK381.11262278
24MAP3K91.08969629
25INSRR1.07032551
26MUSK1.03215075
27TTK1.00194187
28MAPK150.98935813
29STK30.98068598
30PLK40.96312272
31MAP3K130.93810564
32PINK10.93687024
33ATR0.89541402
34AKT30.88219855
35BMX0.86471344
36GRK70.85202814
37IRAK10.85141543
38PRKCI0.83636468
39FGR0.81924078
40CAMK10.81739990
41MAP3K50.77556010
42VRK10.76014571
43WEE10.73524756
44PDK10.71673802
45SGK10.70184863
46CHEK10.70051673
47CAMKK10.68642863
48LIMK10.66539998
49STK160.64410372
50GRK10.61546977
51NLK0.57799065
52ARAF0.56832521
53CDK120.55166487
54MELK0.54999092
55PDGFRA0.54313644
56CHEK20.54040436
57RET0.53138936
58NUAK10.51944211
59MAP2K70.49592939
60ATM0.48872030
61KSR10.47598601
62RPS6KA50.47193722
63TNIK0.44838002
64DAPK20.44775903
65DYRK1B0.44512005
66EGFR0.43534515
67PLK10.42994990
68ADRBK10.42336431
69TYRO30.42242684
70NEK60.42202610
71CAMK1G0.41764514
72DYRK30.41373240
73BMPR20.38820616
74MAP2K20.38587310
75SIK30.37973944
76MKNK20.35500071
77PKN10.35201871
78CLK10.35137985
79MARK10.34343511
80BMPR1B0.33532526
81BRSK20.33452743
82FGFR30.33431843
83CSNK1E0.32461528
84CASK0.32353506
85AURKA0.32102034
86TAOK30.30951747
87TXK0.30915588
88DYRK1A0.30165222
89CDK30.30086588
90RPS6KB10.29633580
91WNK30.29459503
92EPHB10.29183852
93PRKCE0.26950858
94ZAK0.26271929
95BRAF0.26259770
96YES10.24395121
97PRKCG0.24235963
98IRAK20.24142064
99NEK10.23826236
100NTRK30.23757199
101EPHA40.23012401
102RIPK40.22270474
103SRPK10.21666974
104TGFBR10.21570076
105FRK0.19838174
106STK38L0.19666308
107PRKCQ0.19609989
108PAK60.19392549
109NTRK20.19064344
110PLK20.18506861
111MAP3K40.18101178
112CDK10.17933117
113PRKAA10.15733827
114MAPKAPK50.15225538
115CDK20.15046808
116MTOR0.14809359
117PRKG10.14336884
118GSK3B0.12132925
119CAMKK20.11991963
120PAK10.11947245
121BCR0.11869214
122PRKDC0.10557939
123MARK30.09524407
124PRKACB0.08936894
125PDPK10.07278383
126CSNK2A10.07219297
127MAPK80.07015616
128LYN0.06086626
129BLK0.06063343
130CSNK1A10.05841882
131BTK0.05128146
132PDGFRB0.04789309
133CSNK1D0.04306821
134ADRBK20.03310706
135MAPK130.03072666
136CAMK2A0.02876929
137STK110.02790542
138BUB10.02612721
139MAPK100.02523223
140ABL10.02280502
141CSF1R0.02030610
142CSNK2A20.01993040
143RPS6KA30.01725974
144OXSR10.01703015
145PRKCB0.00969716

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.40137906
2Fanconi anemia pathway_Homo sapiens_hsa034603.88254688
3Basal transcription factors_Homo sapiens_hsa030223.63553537
4Pyruvate metabolism_Homo sapiens_hsa006203.50801537
5Dorso-ventral axis formation_Homo sapiens_hsa043202.92995907
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.91979384
7Phototransduction_Homo sapiens_hsa047442.61028601
8beta-Alanine metabolism_Homo sapiens_hsa004102.57653848
9Glucagon signaling pathway_Homo sapiens_hsa049222.39485333
10Propanoate metabolism_Homo sapiens_hsa006402.39309325
11Selenocompound metabolism_Homo sapiens_hsa004502.25498603
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21022214
13Linoleic acid metabolism_Homo sapiens_hsa005912.15992747
14Oocyte meiosis_Homo sapiens_hsa041142.14910720
15Sulfur relay system_Homo sapiens_hsa041222.02590872
16Amphetamine addiction_Homo sapiens_hsa050311.97901892
17Pentose phosphate pathway_Homo sapiens_hsa000301.97805272
18Huntingtons disease_Homo sapiens_hsa050161.93583878
19mRNA surveillance pathway_Homo sapiens_hsa030151.90473974
20Homologous recombination_Homo sapiens_hsa034401.89676812
21Butanoate metabolism_Homo sapiens_hsa006501.89207781
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88634191
23Circadian rhythm_Homo sapiens_hsa047101.78178641
24RNA transport_Homo sapiens_hsa030131.74095143
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.70395290
26Regulation of autophagy_Homo sapiens_hsa041401.66886802
27Ether lipid metabolism_Homo sapiens_hsa005651.56390910
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56071155
29Fatty acid biosynthesis_Homo sapiens_hsa000611.55696258
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55434366
31Renin secretion_Homo sapiens_hsa049241.55394578
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.53052912
33Glycerolipid metabolism_Homo sapiens_hsa005611.43458546
34Long-term potentiation_Homo sapiens_hsa047201.36907316
35Purine metabolism_Homo sapiens_hsa002301.36143542
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30156489
37Phenylalanine metabolism_Homo sapiens_hsa003601.25731436
38Antigen processing and presentation_Homo sapiens_hsa046121.24071084
39Parkinsons disease_Homo sapiens_hsa050121.23977138
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23570725
41RNA degradation_Homo sapiens_hsa030181.21924518
42Hedgehog signaling pathway_Homo sapiens_hsa043401.21159540
43Fatty acid degradation_Homo sapiens_hsa000711.17067208
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.14370797
45Oxidative phosphorylation_Homo sapiens_hsa001901.14224761
46Lysine degradation_Homo sapiens_hsa003101.12667240
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12219553
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08868271
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06477368
50Tryptophan metabolism_Homo sapiens_hsa003801.06086362
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05366769
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04945559
53Cell cycle_Homo sapiens_hsa041101.02429920
54Nicotine addiction_Homo sapiens_hsa050330.99992567
55Glutamatergic synapse_Homo sapiens_hsa047240.97559006
56Calcium signaling pathway_Homo sapiens_hsa040200.97073560
57ABC transporters_Homo sapiens_hsa020100.96174645
58Nitrogen metabolism_Homo sapiens_hsa009100.94469737
59Cardiac muscle contraction_Homo sapiens_hsa042600.93279686
60Pyrimidine metabolism_Homo sapiens_hsa002400.92686764
61Non-homologous end-joining_Homo sapiens_hsa034500.92029426
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82928747
63Caffeine metabolism_Homo sapiens_hsa002320.81948305
64N-Glycan biosynthesis_Homo sapiens_hsa005100.81708784
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81181069
66Fatty acid metabolism_Homo sapiens_hsa012120.77581613
67Mismatch repair_Homo sapiens_hsa034300.76172166
68Base excision repair_Homo sapiens_hsa034100.73338821
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.72400218
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72073170
71Spliceosome_Homo sapiens_hsa030400.71810068
72Taste transduction_Homo sapiens_hsa047420.71567438
73Retinol metabolism_Homo sapiens_hsa008300.71505711
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71257898
75Tyrosine metabolism_Homo sapiens_hsa003500.68772226
76Sphingolipid metabolism_Homo sapiens_hsa006000.68684644
77B cell receptor signaling pathway_Homo sapiens_hsa046620.68487586
78Mineral absorption_Homo sapiens_hsa049780.67902426
79Fructose and mannose metabolism_Homo sapiens_hsa000510.67261474
80Peroxisome_Homo sapiens_hsa041460.66713399
81Nucleotide excision repair_Homo sapiens_hsa034200.65913243
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65820398
83DNA replication_Homo sapiens_hsa030300.64105183
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63947493
85Circadian entrainment_Homo sapiens_hsa047130.62399341
86Basal cell carcinoma_Homo sapiens_hsa052170.62147445
87VEGF signaling pathway_Homo sapiens_hsa043700.62060245
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60047760
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.57262041
90Systemic lupus erythematosus_Homo sapiens_hsa053220.55292049
91Arachidonic acid metabolism_Homo sapiens_hsa005900.54427045
92Morphine addiction_Homo sapiens_hsa050320.52208955
93Serotonergic synapse_Homo sapiens_hsa047260.51975095
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.51688172
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51631411
96Olfactory transduction_Homo sapiens_hsa047400.51564839
97Collecting duct acid secretion_Homo sapiens_hsa049660.51159708
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50518250
99Estrogen signaling pathway_Homo sapiens_hsa049150.48506607
100Choline metabolism in cancer_Homo sapiens_hsa052310.46711868
101Proteasome_Homo sapiens_hsa030500.46066660
102Legionellosis_Homo sapiens_hsa051340.44432682
103Inositol phosphate metabolism_Homo sapiens_hsa005620.43961821
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43890619
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43559419
106PPAR signaling pathway_Homo sapiens_hsa033200.42891572
107Type II diabetes mellitus_Homo sapiens_hsa049300.41591188
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41319578
109T cell receptor signaling pathway_Homo sapiens_hsa046600.40556508
110Steroid biosynthesis_Homo sapiens_hsa001000.39592336
111Fat digestion and absorption_Homo sapiens_hsa049750.39229145
112Carbon metabolism_Homo sapiens_hsa012000.36586865
113Protein export_Homo sapiens_hsa030600.36455280
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36088187
115Alzheimers disease_Homo sapiens_hsa050100.35761300
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35752777
117Measles_Homo sapiens_hsa051620.34194568
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.33416072
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.33245084
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32148039
121Oxytocin signaling pathway_Homo sapiens_hsa049210.32007044
122Epstein-Barr virus infection_Homo sapiens_hsa051690.31502585
123Salivary secretion_Homo sapiens_hsa049700.31305084
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31251377
125Wnt signaling pathway_Homo sapiens_hsa043100.30706178
126Arginine and proline metabolism_Homo sapiens_hsa003300.30560315
127Ovarian steroidogenesis_Homo sapiens_hsa049130.30242280
128cAMP signaling pathway_Homo sapiens_hsa040240.30208375
129Synaptic vesicle cycle_Homo sapiens_hsa047210.30120462
130mTOR signaling pathway_Homo sapiens_hsa041500.29751828
131Alcoholism_Homo sapiens_hsa050340.29228845
132Viral carcinogenesis_Homo sapiens_hsa052030.29048925
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26805214
134Metabolic pathways_Homo sapiens_hsa011000.26719344
135Influenza A_Homo sapiens_hsa051640.26587433
136One carbon pool by folate_Homo sapiens_hsa006700.25331385
137HTLV-I infection_Homo sapiens_hsa051660.24679158
138p53 signaling pathway_Homo sapiens_hsa041150.24558679
139Axon guidance_Homo sapiens_hsa043600.24123343
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23614595
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22902956
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21911269
143Endocytosis_Homo sapiens_hsa041440.20902740
144Herpes simplex infection_Homo sapiens_hsa051680.20676620
145TGF-beta signaling pathway_Homo sapiens_hsa043500.19999828
146Dopaminergic synapse_Homo sapiens_hsa047280.17877246

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