SHANK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.26169184
2synaptic vesicle maturation (GO:0016188)6.18794043
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.80939903
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.37242392
5* positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.31291398
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.84865546
7* regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.74881414
8synaptic vesicle exocytosis (GO:0016079)4.68155729
9* vocalization behavior (GO:0071625)4.68001114
10glutamate secretion (GO:0014047)4.58625076
11* regulation of glutamate receptor signaling pathway (GO:1900449)4.56304507
12regulation of synaptic vesicle exocytosis (GO:2000300)4.51473773
13exploration behavior (GO:0035640)4.49363289
14layer formation in cerebral cortex (GO:0021819)4.47220929
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.40970595
16* regulation of neuronal synaptic plasticity (GO:0048168)4.31732685
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.31460072
18* regulation of long-term neuronal synaptic plasticity (GO:0048169)4.27260684
19* regulation of synapse structural plasticity (GO:0051823)4.25697343
20neurotransmitter secretion (GO:0007269)4.20878281
21protein localization to synapse (GO:0035418)4.18455250
22endothelium development (GO:0003158)4.13023880
23neuronal action potential propagation (GO:0019227)4.04848381
24regulation of synaptic vesicle transport (GO:1902803)4.04823852
25sodium ion export (GO:0071436)4.01943280
26activation of protein kinase A activity (GO:0034199)3.97933387
27gamma-aminobutyric acid transport (GO:0015812)3.97349745
28long-term memory (GO:0007616)3.94536620
29neuromuscular process controlling balance (GO:0050885)3.94216907
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.94076595
31synaptic transmission, glutamatergic (GO:0035249)3.87471714
32cellular potassium ion homeostasis (GO:0030007)3.87349562
33cerebellar granule cell differentiation (GO:0021707)3.77838553
34prepulse inhibition (GO:0060134)3.75313532
35cell communication by electrical coupling (GO:0010644)3.73619415
36glutamate receptor signaling pathway (GO:0007215)3.71551790
37neuron-neuron synaptic transmission (GO:0007270)3.60536172
38positive regulation of synapse maturation (GO:0090129)3.59705782
39proline transport (GO:0015824)3.57916999
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.57638907
41* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53905256
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.53391872
43G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.43256751
44neuron cell-cell adhesion (GO:0007158)3.40409923
45* regulation of dendritic spine morphogenesis (GO:0061001)3.38271250
46lymphangiogenesis (GO:0001946)3.37624169
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.37622969
48* regulation of synaptic plasticity (GO:0048167)3.37113380
49positive regulation of synaptic transmission, GABAergic (GO:0032230)3.36175508
50glycine transport (GO:0015816)3.35921497
51* positive regulation of membrane potential (GO:0045838)3.35826594
52* regulation of postsynaptic membrane potential (GO:0060078)3.31586324
53transmission of nerve impulse (GO:0019226)3.27616662
54regulation of ARF protein signal transduction (GO:0032012)3.27186896
55neurotransmitter transport (GO:0006836)3.23401686
56negative regulation of cytosolic calcium ion concentration (GO:0051481)3.22299893
57neuronal ion channel clustering (GO:0045161)3.20689641
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20360926
59neuromuscular process controlling posture (GO:0050884)3.20132539
60cerebellar Purkinje cell differentiation (GO:0021702)3.18445694
61membrane depolarization during action potential (GO:0086010)3.16971047
62* dendritic spine morphogenesis (GO:0060997)3.15985936
63positive regulation of neurotransmitter transport (GO:0051590)3.15791151
64axon ensheathment in central nervous system (GO:0032291)3.15775441
65central nervous system myelination (GO:0022010)3.15775441
66dendrite morphogenesis (GO:0048813)3.14770202
67potassium ion import (GO:0010107)3.14526712
68regulation of neurotransmitter levels (GO:0001505)3.11447178
69positive regulation of neurotransmitter secretion (GO:0001956)3.10231885
70cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.09021867
71cell communication involved in cardiac conduction (GO:0086065)3.07752169
72regulation of neurotransmitter secretion (GO:0046928)3.07660661
73blood vessel maturation (GO:0001955)3.07630625
74regulation of voltage-gated calcium channel activity (GO:1901385)3.06591359
75establishment of nucleus localization (GO:0040023)3.02617485
76membrane hyperpolarization (GO:0060081)3.01173682
77regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.99444487
78* membrane depolarization (GO:0051899)2.97467499
79neuromuscular process (GO:0050905)2.97042564
80* positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96442431
81* regulation of synaptic transmission, glutamatergic (GO:0051966)2.95517951
82long-term synaptic potentiation (GO:0060291)2.95040799
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94021759
84neuron recognition (GO:0008038)2.93477371
85cytoskeletal anchoring at plasma membrane (GO:0007016)2.92763971
86regulation of neurotransmitter transport (GO:0051588)2.92084088
87cAMP biosynthetic process (GO:0006171)2.90878292
88synaptic vesicle endocytosis (GO:0048488)2.89939346
89dopamine receptor signaling pathway (GO:0007212)2.89100413
90striatum development (GO:0021756)2.87414940
91regulation of female receptivity (GO:0045924)2.86960829
92adenosine receptor signaling pathway (GO:0001973)2.85172881
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83816797
94* neurotransmitter-gated ion channel clustering (GO:0072578)2.83787919
95regulation of membrane repolarization (GO:0060306)2.83372637
96regulation of vesicle fusion (GO:0031338)2.82419556
97visual learning (GO:0008542)2.82279426
98* regulation of dendritic spine development (GO:0060998)2.81613936
99detection of calcium ion (GO:0005513)2.80841425
100vesicle transport along microtubule (GO:0047496)2.79789009
101regulation of synapse maturation (GO:0090128)2.79528219
102cell migration in hindbrain (GO:0021535)2.78893846
103long term synaptic depression (GO:0060292)2.78866767
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78332424
105adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.78303573
106L-amino acid import (GO:0043092)2.77385476
107* learning (GO:0007612)2.76943425
108cellular sodium ion homeostasis (GO:0006883)2.76849729
109cerebellar Purkinje cell layer development (GO:0021680)2.76590268
110negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.75932549
111G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74899925
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.74862657
113* positive regulation of dendritic spine development (GO:0060999)2.68392972
114positive regulation of Rap GTPase activity (GO:0032854)2.66438774
115vascular endothelial growth factor signaling pathway (GO:0038084)2.66339160
116amino acid import (GO:0043090)2.65225074
117potassium ion homeostasis (GO:0055075)2.64421436
118negative regulation of blood vessel endothelial cell migration (GO:0043537)2.63216268
119lymph vessel development (GO:0001945)2.55818587
120negative regulation of dendrite morphogenesis (GO:0050774)2.55282017
121endothelial cell chemotaxis (GO:0035767)2.52471163
122regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.51451679
123regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.50487486
124retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49852483
125neuron remodeling (GO:0016322)2.49343551
126postsynaptic membrane organization (GO:0001941)2.47122655
127cardiac muscle contraction (GO:0060048)2.45760911
128anatomical structure maturation (GO:0071695)2.44813907
129neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.44235775
130positive regulation of vasculogenesis (GO:2001214)2.42488749
131regulation of sodium ion transmembrane transporter activity (GO:2000649)2.40100776
132vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.39599290
133positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.39048982
134regulation of Rap GTPase activity (GO:0032317)2.38739451
135regulation of sodium ion transmembrane transport (GO:1902305)2.38553363
136regulation of cell communication by electrical coupling (GO:0010649)2.38530142
137cardiac conduction (GO:0061337)2.37125444
138cellular response to catecholamine stimulus (GO:0071870)2.35851775
139cellular response to monoamine stimulus (GO:0071868)2.35851775
140negative regulation of endothelial cell migration (GO:0010596)2.34896422
141endothelial cell differentiation (GO:0045446)2.34221700
142* positive regulation of dendrite development (GO:1900006)2.34208369
143cell differentiation in hindbrain (GO:0021533)2.33815928
144gamma-aminobutyric acid signaling pathway (GO:0007214)2.31593219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.35370862
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00611269
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.00468379
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96957620
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89456641
6* DROSHA_22980978_ChIP-Seq_HELA_Human2.86909810
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76182446
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76182446
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.62574111
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59618496
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54747486
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51574184
13REST_21632747_ChIP-Seq_MESCs_Mouse2.50796575
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48960999
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46988996
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44809419
17GBX2_23144817_ChIP-Seq_PC3_Human2.43512188
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33970542
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.33138596
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28379239
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.27901352
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.19357763
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16765419
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.12434943
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.05317245
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.85274527
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78369813
28KDM2B_26808549_Chip-Seq_K562_Human1.66123995
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65121529
30AR_21572438_ChIP-Seq_LNCaP_Human1.64526786
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.62514649
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61196848
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58923635
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58747359
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.56413586
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54433389
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50868706
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.49882346
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47226777
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43430527
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43165195
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42674240
43WT1_25993318_ChIP-Seq_PODOCYTE_Human1.40081371
44* RING1B_27294783_Chip-Seq_ESCs_Mouse1.39263581
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37431674
46* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30412999
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29852775
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29852051
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28127693
50TBX20_22328084_ChIP-Seq_HEART_Mouse1.24549843
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.24549843
52* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23965062
53AR_19668381_ChIP-Seq_PC3_Human1.21761611
54SMAD4_21799915_ChIP-Seq_A2780_Human1.21498506
55* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20985130
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19645080
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.18777479
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18447090
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18045288
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.16680825
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15125152
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14260131
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11654448
64ZNF274_21170338_ChIP-Seq_K562_Hela1.11275661
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10999892
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10820823
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09886335
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.09210575
69* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07708322
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07022745
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06694345
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06672840
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06380670
74CTCF_27219007_Chip-Seq_Bcells_Human1.06343044
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06130715
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05841318
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05034823
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.04909253
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.04147308
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.02775493
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02286333
82TP53_23651856_ChIP-Seq_MEFs_Mouse1.02140094
83SMAD3_21741376_ChIP-Seq_HESCs_Human1.02138951
84* ELK3_25401928_ChIP-Seq_HUVEC_Human1.00937935
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00852933
86* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00819325
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00770162
88* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99999023
89SMAD4_21741376_ChIP-Seq_HESCs_Human0.98992433
90P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97503500
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97500790
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97180607
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97091461
94* LXR_22292898_ChIP-Seq_THP-1_Human0.96796765
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96756587
96OCT4_19829295_ChIP-Seq_ESCs_Human0.96741943
97AHR_22903824_ChIP-Seq_MCF-7_Human0.96552488
98* KDM2B_26808549_Chip-Seq_DND41_Human0.95836470
99KDM2B_26808549_Chip-Seq_JURKAT_Human0.95721922
100STAT3_23295773_ChIP-Seq_U87_Human0.95304843
101CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94432617
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94351652
103KLF4_19829295_ChIP-Seq_ESCs_Human0.94148346
104MYC_27129775_Chip-Seq_CORNEA_Mouse0.93860588
105SMAD3_21741376_ChIP-Seq_EPCs_Human0.93427419
106UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93019478
107YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92983358
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92776724
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92325836
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92061416
111P68_20966046_ChIP-Seq_HELA_Human0.91683299
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.91122369
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.91001012
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90920445
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90728373
116* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90435720
117RXR_22108803_ChIP-Seq_LS180_Human0.90297779
118TCF7_22412390_ChIP-Seq_EML_Mouse0.89755915
119AR_25329375_ChIP-Seq_VCAP_Human0.88907916
120CLOCK_20551151_ChIP-Seq_293T_Human0.88451245
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87809492
122TP53_16413492_ChIP-PET_HCT116_Human0.87539476
123CREB1_26743006_Chip-Seq_LNCaP_Human0.87266264
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87218402
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.86803918
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.86549335
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.86115031
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85892281
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85033748
130SMC4_20622854_ChIP-Seq_HELA_Human0.83650140
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82851351
132* TCF4_23295773_ChIP-Seq_U87_Human0.80733954
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80179355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.13421559
2MP0002822_catalepsy4.40019191
3MP0003635_abnormal_synaptic_transmissio4.21138903
4MP0003880_abnormal_central_pattern3.82909714
5MP0004270_analgesia3.48101231
6MP0009745_abnormal_behavioral_response3.37110433
7MP0002063_abnormal_learning/memory/cond3.30798118
8MP0002064_seizures2.98657001
9MP0009046_muscle_twitch2.98263966
10MP0001879_abnormal_lymphatic_vessel2.88043007
11MP0005423_abnormal_somatic_nervous2.66598088
12MP0002572_abnormal_emotion/affect_behav2.58466896
13MP0005670_abnormal_white_adipose2.49248669
14MP0001486_abnormal_startle_reflex2.46900702
15MP0001968_abnormal_touch/_nociception2.40098421
16MP0002272_abnormal_nervous_system2.39788973
17MP0002734_abnormal_mechanical_nocicepti2.28363306
18MP0002909_abnormal_adrenal_gland2.15335835
19MP0001501_abnormal_sleep_pattern2.13566165
20MP0009780_abnormal_chondrocyte_physiolo2.11454511
21MP0008569_lethality_at_weaning2.10220800
22MP0000751_myopathy1.98108444
23MP0005167_abnormal_blood-brain_barrier1.84053565
24MP0001440_abnormal_grooming_behavior1.80084169
25MP0004858_abnormal_nervous_system1.78242902
26MP0004811_abnormal_neuron_physiology1.75856764
27MP0002733_abnormal_thermal_nociception1.71957818
28MP0003329_amyloid_beta_deposits1.71223504
29MP0003279_aneurysm1.70963735
30MP0004924_abnormal_behavior1.70406125
31MP0005386_behavior/neurological_phenoty1.70406125
32MP0001970_abnormal_pain_threshold1.69681892
33MP0002067_abnormal_sensory_capabilities1.62661049
34MP0002736_abnormal_nociception_after1.61171575
35MP0002735_abnormal_chemical_nociception1.58367317
36MP0002557_abnormal_social/conspecific_i1.57232733
37MP0004215_abnormal_myocardial_fiber1.55164244
38MP0004885_abnormal_endolymph1.53723298
39MP0002184_abnormal_innervation1.49033827
40MP0003633_abnormal_nervous_system1.48828946
41MP0003879_abnormal_hair_cell1.46363332
42MP0004272_abnormal_basement_membrane1.46047966
43MP0002837_dystrophic_cardiac_calcinosis1.45479427
44MP0008961_abnormal_basal_metabolism1.39428822
45MP0000778_abnormal_nervous_system1.39305292
46MP0003075_altered_response_to1.39055183
47MP0005646_abnormal_pituitary_gland1.38247405
48MP0000955_abnormal_spinal_cord1.36812720
49MP0004085_abnormal_heartbeat1.36556133
50MP0005666_abnormal_adipose_tissue1.34888913
51MP0002066_abnormal_motor_capabilities/c1.33209260
52MP0005375_adipose_tissue_phenotype1.32823960
53MP0003705_abnormal_hypodermis_morpholog1.31548633
54MP0004145_abnormal_muscle_electrophysio1.29859824
55MP0005595_abnormal_vascular_smooth1.29122070
56MP0003828_pulmonary_edema1.27667401
57MP0004084_abnormal_cardiac_muscle1.22488762
58MP0003137_abnormal_impulse_conducting1.21085935
59MP0003283_abnormal_digestive_organ1.20761401
60MP0002882_abnormal_neuron_morphology1.20043332
61MP0000013_abnormal_adipose_tissue1.18812552
62MP0003631_nervous_system_phenotype1.18223716
63MP0008874_decreased_physiological_sensi1.15624793
64MP0004130_abnormal_muscle_cell1.10905823
65MP0004510_myositis1.10134650
66MP0003646_muscle_fatigue1.08529272
67MP0003690_abnormal_glial_cell1.07245010
68MP0004036_abnormal_muscle_relaxation1.07189264
69MP0000767_abnormal_smooth_muscle1.07138357
70MP0003123_paternal_imprinting1.06355525
71MP0010630_abnormal_cardiac_muscle1.04543856
72MP0004484_altered_response_of1.02278251
73MP0001529_abnormal_vocalization1.02200529
74MP0008872_abnormal_physiological_respon1.01663097
75MP0001177_atelectasis1.00018508
76MP0001984_abnormal_olfaction0.99195948
77MP0002152_abnormal_brain_morphology0.99194126
78MP0002249_abnormal_larynx_morphology0.98174941
79MP0001502_abnormal_circadian_rhythm0.97976618
80MP0005535_abnormal_body_temperature0.94321117
81MP0005645_abnormal_hypothalamus_physiol0.92131767
82MP0005623_abnormal_meninges_morphology0.90400765
83MP0002127_abnormal_cardiovascular_syste0.89672307
84MP0002295_abnormal_pulmonary_circulatio0.87707671
85MP0002069_abnormal_eating/drinking_beha0.86565527
86MP0005165_increased_susceptibility_to0.85632470
87MP0005620_abnormal_muscle_contractility0.85355691
88MP0000759_abnormal_skeletal_muscle0.84140805
89MP0004782_abnormal_surfactant_physiolog0.84015240
90MP0000569_abnormal_digit_pigmentation0.83882759
91MP0005409_darkened_coat_color0.83669687
92MP0003787_abnormal_imprinting0.83449537
93MP0002638_abnormal_pupillary_reflex0.80914714
94MP0004142_abnormal_muscle_tone0.80439724
95MP0000920_abnormal_myelination0.78757028
96MP0010368_abnormal_lymphatic_system0.78510475
97MP0003122_maternal_imprinting0.78479895
98MP0002106_abnormal_muscle_physiology0.78433563
99MP0002971_abnormal_brown_adipose0.77833909
100MP0003632_abnormal_nervous_system0.76887590
101MP0002332_abnormal_exercise_endurance0.76858084
102MP0006138_congestive_heart_failure0.76839749
103MP0001905_abnormal_dopamine_level0.76818753
104MP0004233_abnormal_muscle_weight0.76662842
105MP0002972_abnormal_cardiac_muscle0.75493923
106MP0005330_cardiomyopathy0.75255185
107MP0003091_abnormal_cell_migration0.74625638
108MP0001958_emphysema0.74307633
109MP0004087_abnormal_muscle_fiber0.73869043
110MP0003045_fibrosis0.73273080
111MP0005369_muscle_phenotype0.72807238
112MP0002128_abnormal_blood_circulation0.71307984
113MP0006276_abnormal_autonomic_nervous0.71234670
114MP0003634_abnormal_glial_cell0.71193220
115MP0002138_abnormal_hepatobiliary_system0.70844111
116MP0000604_amyloidosis0.69254678
117MP0002229_neurodegeneration0.69097710
118MP0008775_abnormal_heart_ventricle0.68479282
119MP0000747_muscle_weakness0.68237125
120MP0005187_abnormal_penis_morphology0.68085914
121MP0002090_abnormal_vision0.66828273
122MP0005385_cardiovascular_system_phenoty0.57817963
123MP0001544_abnormal_cardiovascular_syste0.57817963
124MP0010234_abnormal_vibrissa_follicle0.57131715
125MP0005166_decreased_susceptibility_to0.56460833
126MP0000749_muscle_degeneration0.56442703
127MP0000003_abnormal_adipose_tissue0.56270136
128MP0002089_abnormal_postnatal_growth/wei0.54852512

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.52187809
2Focal motor seizures (HP:0011153)6.57190495
3Focal seizures (HP:0007359)5.30512863
4Visual hallucinations (HP:0002367)5.03691234
5Action tremor (HP:0002345)4.51478918
6Progressive cerebellar ataxia (HP:0002073)3.91173471
7Muscle fiber splitting (HP:0003555)3.82686798
8Epileptic encephalopathy (HP:0200134)3.63642493
9Ankle clonus (HP:0011448)3.50255589
10Ventricular fibrillation (HP:0001663)3.49536636
11Depression (HP:0000716)3.45843224
12Generalized tonic-clonic seizures (HP:0002069)3.37223908
13Annular pancreas (HP:0001734)3.36807082
14Lymphangioma (HP:0100764)3.36659143
15Febrile seizures (HP:0002373)3.36399909
16Dysdiadochokinesis (HP:0002075)3.33873240
17Bundle branch block (HP:0011710)3.33498685
18Atonic seizures (HP:0010819)3.33251505
19Hemiplegia (HP:0002301)3.31689120
20Abnormality of the lower motor neuron (HP:0002366)3.31485164
21Absence seizures (HP:0002121)3.30381838
22Impaired vibration sensation in the lower limbs (HP:0002166)3.30249857
23Gaze-evoked nystagmus (HP:0000640)3.28140398
24Anxiety (HP:0000739)3.24761978
25Supranuclear gaze palsy (HP:0000605)3.23331560
26Hyporeflexia of lower limbs (HP:0002600)3.22645317
27Dysmetric saccades (HP:0000641)3.21737080
28Cerebral aneurysm (HP:0004944)3.21665762
29Papilledema (HP:0001085)3.20307608
30Torticollis (HP:0000473)3.17452647
31Postural instability (HP:0002172)3.15522186
32Dysmetria (HP:0001310)3.07521637
33Urinary bladder sphincter dysfunction (HP:0002839)3.06280916
34Sudden death (HP:0001699)2.96467142
35Dialeptic seizures (HP:0011146)2.95199089
36Genetic anticipation (HP:0003743)2.86112777
37Focal dystonia (HP:0004373)2.85586831
38Mutism (HP:0002300)2.85053348
39* Poor eye contact (HP:0000817)2.84266904
40Prolonged QT interval (HP:0001657)2.82401975
41Intention tremor (HP:0002080)2.80412686
42Impaired smooth pursuit (HP:0007772)2.78615115
43Abnormal eating behavior (HP:0100738)2.76231815
44Urinary urgency (HP:0000012)2.73962717
45* Abnormal social behavior (HP:0012433)2.72088981
46* Impaired social interactions (HP:0000735)2.72088981
47Shallow orbits (HP:0000586)2.71889469
48Abnormal EKG (HP:0003115)2.70938095
49Truncal ataxia (HP:0002078)2.69291972
50Resting tremor (HP:0002322)2.60589000
51Craniofacial dystonia (HP:0012179)2.58636329
52Scanning speech (HP:0002168)2.56859230
53Increased variability in muscle fiber diameter (HP:0003557)2.52870702
54Hemiparesis (HP:0001269)2.52555170
55Heart block (HP:0012722)2.49451040
56Insomnia (HP:0100785)2.49440832
57Primary atrial arrhythmia (HP:0001692)2.48118674
58Atrial fibrillation (HP:0005110)2.47266764
59* Broad-based gait (HP:0002136)2.46926641
60Lower limb amyotrophy (HP:0007210)2.46107745
61Increased connective tissue (HP:0009025)2.45234964
62Amblyopia (HP:0000646)2.44769744
63Abnormality of ocular smooth pursuit (HP:0000617)2.43111007
64Sleep apnea (HP:0010535)2.39995183
65Bradykinesia (HP:0002067)2.38042571
66Atrioventricular block (HP:0001678)2.37037628
67Difficulty climbing stairs (HP:0003551)2.34268427
68Megalencephaly (HP:0001355)2.33976838
69Obstructive sleep apnea (HP:0002870)2.33174099
70Supraventricular tachycardia (HP:0004755)2.31759511
71Supraventricular arrhythmia (HP:0005115)2.31734382
72Bronchomalacia (HP:0002780)2.31336864
73Spastic gait (HP:0002064)2.31243603
74Syncope (HP:0001279)2.29653639
75* Pointed chin (HP:0000307)2.29442665
76Abnormality of binocular vision (HP:0011514)2.28011338
77Diplopia (HP:0000651)2.28011338
78Abnormal atrioventricular conduction (HP:0005150)2.26395123
79Visceral angiomatosis (HP:0100761)2.24633544
80Impaired vibratory sensation (HP:0002495)2.24179408
81Exercise-induced myalgia (HP:0003738)2.23277499
82Aplasia involving bones of the upper limbs (HP:0009823)2.21800682
83Aplasia of the phalanges of the hand (HP:0009802)2.21800682
84Aplasia involving bones of the extremities (HP:0009825)2.21800682
85* Stereotypic behavior (HP:0000733)2.21466814
86Foot dorsiflexor weakness (HP:0009027)2.19503770
87Abnormality of skeletal muscle fiber size (HP:0012084)2.18682648
88Cerebral inclusion bodies (HP:0100314)2.15806342
89Ankyloglossia (HP:0010296)2.15752687
90Neurofibrillary tangles (HP:0002185)2.15460029
91Status epilepticus (HP:0002133)2.14851769
92Protrusio acetabuli (HP:0003179)2.14512770
93Lower limb muscle weakness (HP:0007340)2.14024269
94Abnormality of the foot musculature (HP:0001436)2.13085395
95Distal lower limb muscle weakness (HP:0009053)2.12405553
96Rapidly progressive (HP:0003678)2.12298140
97Incomplete penetrance (HP:0003829)2.11548638
98Polycythemia (HP:0001901)2.10977395
99Hyperventilation (HP:0002883)2.10948907
100Myotonia (HP:0002486)2.06473648
101Excessive salivation (HP:0003781)2.06375164
102Drooling (HP:0002307)2.06375164
103Lower limb asymmetry (HP:0100559)2.06014888
104Hemangiomatosis (HP:0007461)2.05075437
105EMG: neuropathic changes (HP:0003445)2.04881976
106Progressive inability to walk (HP:0002505)2.01687818
107Clonus (HP:0002169)2.00628573
108Deep venous thrombosis (HP:0002625)1.97566814
109Esophageal varix (HP:0002040)1.97368330
110Ventricular arrhythmia (HP:0004308)1.97241278
111Type 1 muscle fiber predominance (HP:0003803)1.96775897
112Complement deficiency (HP:0004431)1.96390030
113Difficulty running (HP:0009046)1.96246767
114Spinal rigidity (HP:0003306)1.96205301
115Abnormality of saccadic eye movements (HP:0000570)1.94662766
116Distal lower limb amyotrophy (HP:0008944)1.94247088
117Limb dystonia (HP:0002451)1.91971869
118EMG: myopathic abnormalities (HP:0003458)1.91231871
119Turricephaly (HP:0000262)1.90611483
120Insidious onset (HP:0003587)1.90137911
121Termporal pattern (HP:0011008)1.90137911
122Hyperacusis (HP:0010780)1.88145071
123Tetraplegia (HP:0002445)1.87031374
124Upper limb amyotrophy (HP:0009129)1.86973274
125Distal upper limb amyotrophy (HP:0007149)1.86973274
126Spinal canal stenosis (HP:0003416)1.85861454
127Amyotrophic lateral sclerosis (HP:0007354)1.85411109
128Epileptiform EEG discharges (HP:0011182)1.85229938
129EEG with generalized epileptiform discharges (HP:0011198)1.84369937
130Gait ataxia (HP:0002066)1.84202419
131Broad metatarsal (HP:0001783)1.83403046
132Centrally nucleated skeletal muscle fibers (HP:0003687)1.79824766
133Wrist flexion contracture (HP:0001239)1.77605346
134Joint hemorrhage (HP:0005261)1.75247446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.80309682
2NTRK33.80987763
3MAP3K93.70293083
4DAPK22.90463109
5PRKD32.88446250
6MARK12.68228166
7MINK12.49463946
8CAMKK12.35078319
9PAK62.32517591
10MAP3K42.30855963
11KSR22.25787165
12NTRK22.10594953
13KDR2.09340541
14RIPK11.96558340
15NTRK11.89626467
16STK381.64679913
17MAP2K41.56877092
18CDK51.55638997
19MAP2K71.53559430
20RIPK41.51181821
21TAOK11.49831458
22DAPK11.47703544
23SIK21.46822502
24KSR11.46722150
25TYRO31.46561618
26TIE11.35626425
27PHKG11.35228255
28PHKG21.35228255
29PRPF4B1.35199464
30FES1.30859206
31CAMKK21.25381621
32EPHB21.24629054
33LMTK21.22825703
34PRKCH1.20165997
35TTN1.17295801
36CAMK11.14604999
37TRIB31.14034402
38MAP3K21.11848798
39STK111.08288271
40ALK1.07678844
41EEF2K1.07106852
42UHMK11.05857324
43MAP3K131.04330395
44PINK11.04212928
45GRK51.03308639
46DMPK1.03216980
47TNIK0.99270555
48PTK2B0.97390243
49LATS20.97235147
50RET0.96304769
51MARK20.95086108
52PRKCG0.94549557
53TGFBR20.93653089
54MAPK150.93311048
55SGK30.86478043
56SGK2230.82833160
57SGK4940.82833160
58PDPK10.82817106
59NEK10.82751615
60MAP3K120.82555949
61ARAF0.82427897
62PDK10.81902396
63MAPK130.80735499
64OBSCN0.79761041
65MAP3K110.78445104
66CAMK1G0.78188518
67CDK150.77424159
68CAMK2A0.77325560
69CDK180.76879879
70PAK30.76734819
71MAP3K70.76167557
72CAMK40.75549601
73SGK20.73013842
74SGK10.71062574
75CDK140.70997687
76RAF10.68844333
77PTK20.68363158
78PRKG20.67691444
79PDGFRA0.66728909
80MAP3K10.66677045
81DDR20.66235338
82CDK190.66174659
83CDK11A0.66098163
84PLK20.65934941
85CDC42BPA0.64308296
86MAP3K60.63411862
87PKN10.62453618
88PNCK0.61539620
89PRKAA20.59977466
90ROCK10.59799721
91SIK10.58454945
92MAPK70.58387293
93WNK10.56865739
94RPS6KA30.56683487
95MAPK40.55747971
96CAMK2B0.54200687
97FYN0.53264650
98DAPK30.52252595
99WNK40.51468533
100PRKAA10.49067011
101PKN20.48705565
102ICK0.48531845
103PRKCZ0.47990484
104FGFR40.47608127
105PRKD20.47181267
106PRKD10.46473210
107MAPK120.44888811
108MAPK100.43816085
109TNK20.43727439
110FGFR20.43174608
111HIPK20.42861843
112ROCK20.42823055
113DYRK1A0.41610641
114MTOR0.41176483
115BRSK10.40555800
116PRKG10.39885841
117MAP2K10.38083611
118SCYL20.38082691
119TRPM70.37750375
120CAMK2D0.37420030
121RPS6KA20.36461489
122BMX0.36378228
123MYLK0.36093573
124FER0.34903762
125MAPK80.34331103
126NEK60.33656202
127PRKCE0.33258882
128CAMK2G0.31893287

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.87034107
2Olfactory transduction_Homo sapiens_hsa047402.80080102
3Circadian entrainment_Homo sapiens_hsa047132.62512247
4Synaptic vesicle cycle_Homo sapiens_hsa047212.61326020
5Long-term potentiation_Homo sapiens_hsa047202.48387891
6GABAergic synapse_Homo sapiens_hsa047272.44949899
7Morphine addiction_Homo sapiens_hsa050322.37386463
8* Glutamatergic synapse_Homo sapiens_hsa047242.36420434
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28625802
10Amphetamine addiction_Homo sapiens_hsa050312.24290054
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14613426
12Salivary secretion_Homo sapiens_hsa049702.11413516
13Aldosterone synthesis and secretion_Homo sapiens_hsa049252.00949812
14Dopaminergic synapse_Homo sapiens_hsa047281.98495034
15Gastric acid secretion_Homo sapiens_hsa049711.96219331
16Cholinergic synapse_Homo sapiens_hsa047251.92938089
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.91612568
18Insulin secretion_Homo sapiens_hsa049111.88163435
19Nitrogen metabolism_Homo sapiens_hsa009101.84736049
20Oxytocin signaling pathway_Homo sapiens_hsa049211.70997164
21Renin secretion_Homo sapiens_hsa049241.70928452
22Cocaine addiction_Homo sapiens_hsa050301.69214791
23Calcium signaling pathway_Homo sapiens_hsa040201.58117075
24Long-term depression_Homo sapiens_hsa047301.48141352
25GnRH signaling pathway_Homo sapiens_hsa049121.46798495
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45867780
27Taste transduction_Homo sapiens_hsa047421.44738693
28Gap junction_Homo sapiens_hsa045401.41299105
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40216490
30cAMP signaling pathway_Homo sapiens_hsa040241.36481956
31Type II diabetes mellitus_Homo sapiens_hsa049301.34138178
32Serotonergic synapse_Homo sapiens_hsa047261.26565285
33Dilated cardiomyopathy_Homo sapiens_hsa054141.25852100
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24453388
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23445744
36Estrogen signaling pathway_Homo sapiens_hsa049151.20580390
37Glioma_Homo sapiens_hsa052141.18173519
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17581155
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11367033
40ECM-receptor interaction_Homo sapiens_hsa045121.08404251
41Cardiac muscle contraction_Homo sapiens_hsa042601.08093708
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02301865
43Melanogenesis_Homo sapiens_hsa049161.01975695
44Axon guidance_Homo sapiens_hsa043601.01532509
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.01017698
46Dorso-ventral axis formation_Homo sapiens_hsa043201.00487658
47Vitamin B6 metabolism_Homo sapiens_hsa007501.00023741
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.99902271
49PPAR signaling pathway_Homo sapiens_hsa033200.99273321
50ErbB signaling pathway_Homo sapiens_hsa040120.93853717
51Notch signaling pathway_Homo sapiens_hsa043300.92346103
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88837871
53Pancreatic secretion_Homo sapiens_hsa049720.88318488
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87895105
55Arginine and proline metabolism_Homo sapiens_hsa003300.87815804
56Phenylalanine metabolism_Homo sapiens_hsa003600.86292553
57Histidine metabolism_Homo sapiens_hsa003400.83619753
58Bile secretion_Homo sapiens_hsa049760.81468609
59Thyroid hormone synthesis_Homo sapiens_hsa049180.81318439
60VEGF signaling pathway_Homo sapiens_hsa043700.80272137
61Oocyte meiosis_Homo sapiens_hsa041140.79873992
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78353285
63Complement and coagulation cascades_Homo sapiens_hsa046100.78317839
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76514703
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76403606
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76356113
67Rap1 signaling pathway_Homo sapiens_hsa040150.74498895
68AMPK signaling pathway_Homo sapiens_hsa041520.72821727
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72786657
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.71987658
71Choline metabolism in cancer_Homo sapiens_hsa052310.70233314
72MAPK signaling pathway_Homo sapiens_hsa040100.69535364
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68240204
74Glucagon signaling pathway_Homo sapiens_hsa049220.67553838
75mTOR signaling pathway_Homo sapiens_hsa041500.67336867
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65421408
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63475939
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59411459
79Non-small cell lung cancer_Homo sapiens_hsa052230.59317147
80Endocytosis_Homo sapiens_hsa041440.57381328
81Ras signaling pathway_Homo sapiens_hsa040140.55746405
82Amoebiasis_Homo sapiens_hsa051460.54938761
83Insulin signaling pathway_Homo sapiens_hsa049100.54493365
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.53307435
85Endometrial cancer_Homo sapiens_hsa052130.52073083
86ABC transporters_Homo sapiens_hsa020100.51505913
87Arginine biosynthesis_Homo sapiens_hsa002200.51284945
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50985431
89Renal cell carcinoma_Homo sapiens_hsa052110.49579388
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48856611
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48126103
92Platelet activation_Homo sapiens_hsa046110.48061067
93Adherens junction_Homo sapiens_hsa045200.47783845
94Collecting duct acid secretion_Homo sapiens_hsa049660.47160719
95Inositol phosphate metabolism_Homo sapiens_hsa005620.47096021
96Ovarian steroidogenesis_Homo sapiens_hsa049130.46750058
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45664994
98Prion diseases_Homo sapiens_hsa050200.44379507
99Protein digestion and absorption_Homo sapiens_hsa049740.43811906
100Chemokine signaling pathway_Homo sapiens_hsa040620.43596080
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43434002
102HIF-1 signaling pathway_Homo sapiens_hsa040660.42742397
103Alcoholism_Homo sapiens_hsa050340.42346451
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.41634748
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40606422
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39426296
107Fatty acid degradation_Homo sapiens_hsa000710.37843525
108Circadian rhythm_Homo sapiens_hsa047100.36933641
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.36375824
110Fatty acid biosynthesis_Homo sapiens_hsa000610.36343840
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35823430
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.34630112
113Tight junction_Homo sapiens_hsa045300.33223645
114Wnt signaling pathway_Homo sapiens_hsa043100.32479429
115African trypanosomiasis_Homo sapiens_hsa051430.32196252
116Focal adhesion_Homo sapiens_hsa045100.31773070
117Insulin resistance_Homo sapiens_hsa049310.31539415
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31179612

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