SH3YL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.67844037
2pyrimidine nucleobase catabolic process (GO:0006208)5.03175022
3L-phenylalanine catabolic process (GO:0006559)4.57913119
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.57913119
5protoporphyrinogen IX biosynthetic process (GO:0006782)4.31353913
6nucleobase catabolic process (GO:0046113)4.30094024
7L-phenylalanine metabolic process (GO:0006558)4.28478849
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.28478849
9protoporphyrinogen IX metabolic process (GO:0046501)4.25794173
10sphingoid metabolic process (GO:0046519)4.17334120
11L-fucose catabolic process (GO:0042355)4.04441742
12fucose catabolic process (GO:0019317)4.04441742
13L-fucose metabolic process (GO:0042354)4.04441742
14drug catabolic process (GO:0042737)3.86425830
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.84689285
16cysteine metabolic process (GO:0006534)3.74997453
17sulfur amino acid catabolic process (GO:0000098)3.71049181
18Golgi to endosome transport (GO:0006895)3.63738469
19aromatic amino acid family catabolic process (GO:0009074)3.49087589
20diol metabolic process (GO:0034311)3.48105799
21regulation of memory T cell differentiation (GO:0043380)3.40246199
22axoneme assembly (GO:0035082)3.39690423
23sphingosine metabolic process (GO:0006670)3.38658177
24cellular ketone body metabolic process (GO:0046950)3.38062661
25bundle of His cell to Purkinje myocyte communication (GO:0086069)3.33549423
26exogenous drug catabolic process (GO:0042738)3.28375108
27nephron tubule morphogenesis (GO:0072078)3.26382897
28nephron epithelium morphogenesis (GO:0072088)3.26382897
29glutathione derivative biosynthetic process (GO:1901687)3.19811475
30glutathione derivative metabolic process (GO:1901685)3.19811475
31transepithelial transport (GO:0070633)3.19587279
32establishment of skin barrier (GO:0061436)3.19107633
33reflex (GO:0060004)3.17206403
34protein localization to cilium (GO:0061512)3.16944468
353-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.16429437
36purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.16429437
37regulation of water loss via skin (GO:0033561)3.14710161
38uronic acid metabolic process (GO:0006063)3.14382006
39glucuronate metabolic process (GO:0019585)3.14382006
40intestinal cholesterol absorption (GO:0030299)3.14134428
41cilium or flagellum-dependent cell motility (GO:0001539)3.13031426
42regulation of type B pancreatic cell apoptotic process (GO:2000674)3.09849524
43kidney morphogenesis (GO:0060993)3.09264862
44endocrine pancreas development (GO:0031018)3.08434949
45regulation of phospholipase A2 activity (GO:0032429)3.06968713
46phosphatidylinositol acyl-chain remodeling (GO:0036149)3.03222672
47calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.02823809
48intestinal absorption (GO:0050892)3.01188757
49cellular glucuronidation (GO:0052695)2.99384358
50auditory receptor cell differentiation (GO:0042491)2.98909292
51indolalkylamine catabolic process (GO:0046218)2.97768642
52tryptophan catabolic process (GO:0006569)2.97768642
53indole-containing compound catabolic process (GO:0042436)2.97768642
54phosphatidylserine acyl-chain remodeling (GO:0036150)2.97266235
55phenylpropanoid metabolic process (GO:0009698)2.96768143
56tryptophan metabolic process (GO:0006568)2.96205213
57macroautophagy (GO:0016236)2.90894972
58glyoxylate metabolic process (GO:0046487)2.88736979
59glutathione biosynthetic process (GO:0006750)2.88296628
60ketone body metabolic process (GO:1902224)2.87988151
61flavonoid metabolic process (GO:0009812)2.87396983
62nonribosomal peptide biosynthetic process (GO:0019184)2.87012517
63phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.86836844
64porphyrin-containing compound biosynthetic process (GO:0006779)2.86345972
65regulation of hexokinase activity (GO:1903299)2.86149865
66regulation of glucokinase activity (GO:0033131)2.86149865
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.85455002
68transcytosis (GO:0045056)2.82976686
69epithelial cilium movement (GO:0003351)2.82878929
70cilium movement (GO:0003341)2.82414529
71regulation of protein glycosylation (GO:0060049)2.81817312
72regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.81585448
73negative regulation of keratinocyte proliferation (GO:0010839)2.81580368
74prostate gland growth (GO:0060736)2.81091176
75keratinocyte proliferation (GO:0043616)2.79739957
76xenobiotic catabolic process (GO:0042178)2.79358196
77coenzyme catabolic process (GO:0009109)2.79330168
78amino-acid betaine metabolic process (GO:0006577)2.78071865
79establishment of protein localization to Golgi (GO:0072600)2.77054936
80short-chain fatty acid metabolic process (GO:0046459)2.76975503
81lysine metabolic process (GO:0006553)2.75499837
82lysine catabolic process (GO:0006554)2.75499837
83negative regulation of protein oligomerization (GO:0032460)2.75189478
84water-soluble vitamin biosynthetic process (GO:0042364)2.74797235
85intestinal epithelial cell development (GO:0060576)2.73975849
86glandular epithelial cell differentiation (GO:0002067)2.73413468
87negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73319505
88positive regulation of glycolytic process (GO:0045821)2.72838516
89glutathione metabolic process (GO:0006749)2.69545369
90high-density lipoprotein particle remodeling (GO:0034375)2.69460745
91cellular modified amino acid catabolic process (GO:0042219)2.69404619
92positive regulation of glycoprotein biosynthetic process (GO:0010560)2.69313684
93bile acid and bile salt transport (GO:0015721)2.68199608
94drug transmembrane transport (GO:0006855)2.68097068
95heme biosynthetic process (GO:0006783)2.68072822
96aldehyde catabolic process (GO:0046185)2.67698808
97pyrimidine-containing compound transmembrane transport (GO:0072531)2.65845369
98benzene-containing compound metabolic process (GO:0042537)2.65502762
99digestion (GO:0007586)2.65261797
100protein localization to Golgi apparatus (GO:0034067)2.64361109
101photoreceptor cell maintenance (GO:0045494)2.63817909
102aromatic amino acid family metabolic process (GO:0009072)2.62925484
103protein targeting to Golgi (GO:0000042)2.62728302
104tetrapyrrole biosynthetic process (GO:0033014)2.62197273
105insulin secretion (GO:0030073)2.61381624
106kynurenine metabolic process (GO:0070189)2.61380848
107nonmotile primary cilium assembly (GO:0035058)2.61344782
108bile acid biosynthetic process (GO:0006699)2.60502746
109one-carbon compound transport (GO:0019755)2.60329551
110polyol catabolic process (GO:0046174)2.59225391
111axonemal dynein complex assembly (GO:0070286)2.57501009
112thyroid hormone metabolic process (GO:0042403)2.55902347
113lung lobe morphogenesis (GO:0060463)2.55875706
114oligosaccharide biosynthetic process (GO:0009312)2.55818758
115renal tubule morphogenesis (GO:0061333)2.54386267
116peptide hormone processing (GO:0016486)2.54119545
117urate metabolic process (GO:0046415)2.52463606
118drug metabolic process (GO:0017144)2.52283668
119regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.51206844
120porphyrin-containing compound metabolic process (GO:0006778)2.51206638
121inositol phosphate catabolic process (GO:0071545)2.50832010
122fucosylation (GO:0036065)2.50390309
123keratinocyte development (GO:0003334)2.50368323
124carnitine metabolic process (GO:0009437)2.50218750
125response to phenylpropanoid (GO:0080184)2.49672392
126water homeostasis (GO:0030104)2.47277459
127ethanol metabolic process (GO:0006067)2.47239637
128early endosome to late endosome transport (GO:0045022)2.46916757
129heme metabolic process (GO:0042168)2.46741487
130negative regulation of lipase activity (GO:0060192)2.46395940
131zinc ion homeostasis (GO:0055069)2.45811729
132retrograde transport, vesicle recycling within Golgi (GO:0000301)2.42355473
133regulation of cilium movement (GO:0003352)2.42338947
134regulation of acrosome reaction (GO:0060046)2.41476309
135peroxisome fission (GO:0016559)2.40659962
136negative regulation of hormone biosynthetic process (GO:0032353)2.40653836
137piRNA metabolic process (GO:0034587)2.40467293
138homocysteine metabolic process (GO:0050667)2.39882370
139regulation of bile acid biosynthetic process (GO:0070857)2.39600502
140negative regulation of hormone metabolic process (GO:0032351)2.39107075
141positive regulation of respiratory burst (GO:0060267)2.39050283
142bile acid metabolic process (GO:0008206)2.38830540
143phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.37969964
144triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.37858036
145inositol phosphate dephosphorylation (GO:0046855)2.37596887
146phosphorylated carbohydrate dephosphorylation (GO:0046838)2.37596887
147auditory receptor cell stereocilium organization (GO:0060088)2.37026800
148cell migration in hindbrain (GO:0021535)2.36666864
149multicellular organismal water homeostasis (GO:0050891)2.35958408
150serine family amino acid catabolic process (GO:0009071)2.35482431
151antibacterial humoral response (GO:0019731)2.34212863
152tyrosine metabolic process (GO:0006570)2.33593732
153cofactor catabolic process (GO:0051187)2.33453160
154indolalkylamine metabolic process (GO:0006586)2.33425085
155behavioral response to nicotine (GO:0035095)2.32140743
156positive regulation of vesicle fusion (GO:0031340)2.31892060
157estrogen biosynthetic process (GO:0006703)2.30539250
158sulfate transmembrane transport (GO:1902358)2.29195120
159toxin metabolic process (GO:0009404)2.28780545
160positive regulation of fatty acid transport (GO:2000193)2.28265760
161drug transport (GO:0015893)2.27471710
162regulation of heart rate by cardiac conduction (GO:0086091)2.27328447
163xenobiotic metabolic process (GO:0006805)2.27252195
164cilium organization (GO:0044782)2.26528842
165positive regulation of glycoprotein metabolic process (GO:1903020)2.25164015
166dendritic spine morphogenesis (GO:0060997)2.24527925
167urea cycle (GO:0000050)2.24518569
168urea metabolic process (GO:0019627)2.24518569
169membrane budding (GO:0006900)2.24424335
170primary alcohol catabolic process (GO:0034310)2.24252706
171proline transport (GO:0015824)2.24229337
172phospholipid efflux (GO:0033700)2.23868976
173phosphatidylcholine biosynthetic process (GO:0006656)2.23828486
174L-ascorbic acid metabolic process (GO:0019852)2.23676672
175mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.23607075
176protein carboxylation (GO:0018214)2.23583019
177acrosome reaction (GO:0007340)2.22872979
178photoreceptor cell differentiation (GO:0046530)2.21989080
179eye photoreceptor cell differentiation (GO:0001754)2.21989080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.69392202
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.45957899
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.43684864
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.54311443
5EZH2_22144423_ChIP-Seq_EOC_Human2.40526562
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28945677
7* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11066728
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.10951155
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09245125
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.07404895
11* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.98532563
12FLI1_27457419_Chip-Seq_LIVER_Mouse1.95321557
13ER_23166858_ChIP-Seq_MCF-7_Human1.92317766
14* LXR_22158963_ChIP-Seq_LIVER_Mouse1.91887314
15FUS_26573619_Chip-Seq_HEK293_Human1.87290652
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87121833
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83364814
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79945752
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76609905
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.73825810
21IGF1R_20145208_ChIP-Seq_DFB_Human1.72456852
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70806890
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62778955
24* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58208085
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.57652941
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57208117
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.55166793
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51935657
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.51750137
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47387908
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47322146
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45483688
33TAF15_26573619_Chip-Seq_HEK293_Human1.44397896
34GBX2_23144817_ChIP-Seq_PC3_Human1.43828926
35VDR_22108803_ChIP-Seq_LS180_Human1.43719262
36STAT3_23295773_ChIP-Seq_U87_Human1.43205628
37* SOX2_20726797_ChIP-Seq_SW620_Human1.42528916
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42438822
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42252202
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.41839379
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40234050
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40101772
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39600175
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38813451
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38634178
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38309386
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.37863615
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37703161
49CDX2_22108803_ChIP-Seq_LS180_Human1.36472978
50TCF4_23295773_ChIP-Seq_U87_Human1.36286176
51P53_22387025_ChIP-Seq_ESCs_Mouse1.36255530
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.35936518
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35432361
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34444072
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34052899
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34033347
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33925203
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33827009
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.33131047
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30626516
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30045847
62CBP_20019798_ChIP-Seq_JUKART_Human1.30045847
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29264435
64ZNF274_21170338_ChIP-Seq_K562_Hela1.28667526
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27310003
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.26790105
67TCF4_22108803_ChIP-Seq_LS180_Human1.26770017
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.26297119
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.26021951
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24381256
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23705059
72EWS_26573619_Chip-Seq_HEK293_Human1.23534910
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.22392186
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.22193255
75GATA4_25053715_ChIP-Seq_YYC3_Human1.20655024
76* RNF2_27304074_Chip-Seq_NSC_Mouse1.20596323
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.20280323
78FOXA1_25552417_ChIP-Seq_VCAP_Human1.20255761
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19905106
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19636503
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.18954627
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18082897
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.18035593
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17958094
85RUNX2_22187159_ChIP-Seq_PCA_Human1.17802886
86EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15192510
87RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15192510
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15072348
89P300_19829295_ChIP-Seq_ESCs_Human1.14578761
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14345941
91ZNF263_19887448_ChIP-Seq_K562_Human1.13958753
92JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13941309
93P300_18555785_Chip-Seq_ESCs_Mouse1.13367718
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.12730938
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12730938
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11980608
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.11745372
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.11660459
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.10810834
100BCAT_22108803_ChIP-Seq_LS180_Human1.10338510
101SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10100493
102AHR_22903824_ChIP-Seq_MCF-7_Human1.09992799
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09364478
104DROSHA_22980978_ChIP-Seq_HELA_Human1.09196337
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.08761933
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08020279
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08020279
108ESR2_21235772_ChIP-Seq_MCF-7_Human1.07911728
109CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07745438
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07440686
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.07190842
112TCF4_18268006_ChIP-ChIP_LS174T_Human1.07083411
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05904643
114HTT_18923047_ChIP-ChIP_STHdh_Human1.05658505
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05071694
116RXR_22108803_ChIP-Seq_LS180_Human1.04760453
117FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04668490
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03534000
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03271997
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03271997
121POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02790682
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02453691
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02308517
124SMAD3_21741376_ChIP-Seq_HESCs_Human1.01291817
125* FLI1_21867929_ChIP-Seq_TH2_Mouse1.00824136
126TRIM28_21343339_ChIP-Seq_HEK293_Human1.00586296
127* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99875422
128SMAD4_21799915_ChIP-Seq_A2780_Human0.98713839
129* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94841709
130AR_25329375_ChIP-Seq_VCAP_Human0.93862002
131* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93669300
132SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93544180
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.93378946
134GATA6_25053715_ChIP-Seq_YYC3_Human0.92831971
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92716772
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90248430
137PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90012864
138ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89941541
139CDX2_20551321_ChIP-Seq_CACO-2_Human0.89925011
140REST_21632747_ChIP-Seq_MESCs_Mouse0.89773970
141PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88874644
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88638582
143* TP63_23658742_ChIP-Seq_EP156T_Human0.88362064
144TP53_18474530_ChIP-ChIP_U2OS_Human0.88139239
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87444554
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87320684
147TAL1_26923725_Chip-Seq_HPCs_Mouse0.86486134
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86477059
149* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86227048
150GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85910862
151* KLF5_25053715_ChIP-Seq_YYC3_Human0.84652731
152SMAD3_21741376_ChIP-Seq_EPCs_Human0.84370843
153PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82292997
154TP53_20018659_ChIP-ChIP_R1E_Mouse0.82211404
155SOX2_19829295_ChIP-Seq_ESCs_Human0.81631010
156NANOG_19829295_ChIP-Seq_ESCs_Human0.81631010
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81121474
158CJUN_26792858_Chip-Seq_BT549_Human0.80590105
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79428000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.61986537
2MP0010234_abnormal_vibrissa_follicle4.25651854
3MP0005360_urolithiasis3.90025523
4MP0005085_abnormal_gallbladder_physiolo3.41530546
5MP0009780_abnormal_chondrocyte_physiolo3.39341421
6MP0010386_abnormal_urinary_bladder3.02010875
7MP0008875_abnormal_xenobiotic_pharmacok2.97006970
8MP0005365_abnormal_bile_salt2.95554197
9MP0002796_impaired_skin_barrier2.74189663
10MP0002909_abnormal_adrenal_gland2.70041912
11MP0000537_abnormal_urethra_morphology2.43133704
12MP0000538_abnormal_urinary_bladder2.17321065
13MP0001666_abnormal_nutrient_absorption2.16169105
14MP0008789_abnormal_olfactory_epithelium2.13277552
15MP0004885_abnormal_endolymph2.10693976
16MP0008877_abnormal_DNA_methylation2.10511973
17MP0004264_abnormal_extraembryonic_tissu2.06295517
18MP0003656_abnormal_erythrocyte_physiolo2.02976724
19MP0002735_abnormal_chemical_nociception2.01391738
20MP0005646_abnormal_pituitary_gland1.94121890
21MP0005394_taste/olfaction_phenotype1.88937754
22MP0005499_abnormal_olfactory_system1.88937754
23MP0005083_abnormal_biliary_tract1.78199116
24MP0009379_abnormal_foot_pigmentation1.76849522
25MP0003195_calcinosis1.76665424
26MP0004019_abnormal_vitamin_homeostasis1.75238599
27MP0005501_abnormal_skin_physiology1.74907530
28MP0001501_abnormal_sleep_pattern1.74473124
29MP0001984_abnormal_olfaction1.74160099
30MP0005379_endocrine/exocrine_gland_phen1.71885251
31MP0003806_abnormal_nucleotide_metabolis1.71300421
32MP0005645_abnormal_hypothalamus_physiol1.65331831
33MP0004270_analgesia1.63170054
34MP0004147_increased_porphyrin_level1.60989302
35MP0000013_abnormal_adipose_tissue1.60637600
36MP0008872_abnormal_physiological_respon1.59897780
37MP0003941_abnormal_skin_development1.59307857
38MP0005636_abnormal_mineral_homeostasis1.58822706
39MP0004043_abnormal_pH_regulation1.57665310
40MP0001986_abnormal_taste_sensitivity1.51401871
41MP0003283_abnormal_digestive_organ1.49790209
42MP0002638_abnormal_pupillary_reflex1.49575327
43MP0002098_abnormal_vibrissa_morphology1.49209701
44MP0005408_hypopigmentation1.47771914
45MP0008004_abnormal_stomach_pH1.46049205
46MP0006276_abnormal_autonomic_nervous1.44133758
47MP0010678_abnormal_skin_adnexa1.42610839
48MP0005075_abnormal_melanosome_morpholog1.38023626
49MP0005451_abnormal_body_composition1.36654691
50MP0005551_abnormal_eye_electrophysiolog1.34954644
51MP0002736_abnormal_nociception_after1.34429464
52MP0003315_abnormal_perineum_morphology1.33662280
53MP0002734_abnormal_mechanical_nocicepti1.33484895
54MP0003122_maternal_imprinting1.32688678
55MP0010771_integument_phenotype1.31488526
56MP0006072_abnormal_retinal_apoptosis1.30323053
57MP0005332_abnormal_amino_acid1.29248769
58MP0001968_abnormal_touch/_nociception1.28120891
59MP0000579_abnormal_nail_morphology1.26516197
60MP0010329_abnormal_lipoprotein_level1.26407290
61MP0002876_abnormal_thyroid_physiology1.25732702
62MP0003252_abnormal_bile_duct1.23979438
63MP0003011_delayed_dark_adaptation1.23285365
64MP0009046_muscle_twitch1.23145024
65MP0000383_abnormal_hair_follicle1.22951082
66MP0001485_abnormal_pinna_reflex1.22537975
67MP0001664_abnormal_digestion1.22280445
68MP0001756_abnormal_urination1.22139760
69MP0005187_abnormal_penis_morphology1.22017297
70MP0002693_abnormal_pancreas_physiology1.17551951
71MP0002060_abnormal_skin_morphology1.14247400
72MP0001529_abnormal_vocalization1.13592269
73MP0004484_altered_response_of1.11850512
74MP0005084_abnormal_gallbladder_morpholo1.10446904
75MP0009745_abnormal_behavioral_response1.10218312
76MP0005220_abnormal_exocrine_pancreas1.10103892
77MP0000566_synostosis1.08700069
78MP0005386_behavior/neurological_phenoty1.07423676
79MP0004924_abnormal_behavior1.07423676
80MP0003787_abnormal_imprinting1.07217091
81MP0001216_abnormal_epidermal_layer1.07209850
82MP0003868_abnormal_feces_composition1.07036793
83MP0000569_abnormal_digit_pigmentation1.06767008
84MP0001765_abnormal_ion_homeostasis1.06535000
85MP0000462_abnormal_digestive_system1.05539682
86MP0002163_abnormal_gland_morphology1.05017292
87MP0009643_abnormal_urine_homeostasis1.04647820
88MP0002160_abnormal_reproductive_system1.04020718
89MP0002184_abnormal_innervation1.03209455
90MP0002733_abnormal_thermal_nociception1.03154450
91MP0002928_abnormal_bile_duct1.03007334
92MP0001486_abnormal_startle_reflex1.01107917
93MP0002009_preneoplasia1.00145884
94MP0000534_abnormal_ureter_morphology0.98822820
95MP0000427_abnormal_hair_cycle0.98537889
96MP0003453_abnormal_keratinocyte_physiol0.97403857
97MP0009053_abnormal_anal_canal0.97158853
98MP0000631_abnormal_neuroendocrine_gland0.95709832
99MP0005448_abnormal_energy_balance0.95310492
100MP0002233_abnormal_nose_morphology0.95059380
101MP0005253_abnormal_eye_physiology0.94520354
102MP0001905_abnormal_dopamine_level0.92925430
103MP0003953_abnormal_hormone_level0.92330242
104MP0005174_abnormal_tail_pigmentation0.91543033
105MP0002102_abnormal_ear_morphology0.91151198
106MP0003878_abnormal_ear_physiology0.90920717
107MP0005377_hearing/vestibular/ear_phenot0.90920717
108MP0002272_abnormal_nervous_system0.90613088
109MP0002254_reproductive_system_inflammat0.90600695
110MP0002078_abnormal_glucose_homeostasis0.90527396
111MP0003879_abnormal_hair_cell0.90356364
112MP0002277_abnormal_respiratory_mucosa0.89670774
113MP0005248_abnormal_Harderian_gland0.89248022
114MP0005367_renal/urinary_system_phenotyp0.88717187
115MP0000516_abnormal_urinary_system0.88717187
116MP0001502_abnormal_circadian_rhythm0.86745926
117MP0000778_abnormal_nervous_system0.86440577
118MP0000470_abnormal_stomach_morphology0.85359684
119MP0000467_abnormal_esophagus_morphology0.85066465
120MP0002557_abnormal_social/conspecific_i0.84993188
121MP0002572_abnormal_emotion/affect_behav0.84780594
122MP0000230_abnormal_systemic_arterial0.83659242
123MP0002822_catalepsy0.82963360
124MP0001970_abnormal_pain_threshold0.82240472
125MP0000639_abnormal_adrenal_gland0.81507755
126MP0005389_reproductive_system_phenotype0.79934003
127MP0001346_abnormal_lacrimal_gland0.79529641
128MP0003718_maternal_effect0.79410936
129MP0002118_abnormal_lipid_homeostasis0.78985326
130MP0002136_abnormal_kidney_physiology0.78041874
131MP0000647_abnormal_sebaceous_gland0.77989440
132MP0002938_white_spotting0.77748004
133MP0002234_abnormal_pharynx_morphology0.77494878
134MP0005410_abnormal_fertilization0.77172544
135MP0003638_abnormal_response/metabolism_0.75801326
136MP0002837_dystrophic_cardiac_calcinosis0.75613887
137MP0009697_abnormal_copulation0.75197763
138MP0001764_abnormal_homeostasis0.73717722
139MP0000762_abnormal_tongue_morphology0.71306357
140MP0000678_abnormal_parathyroid_gland0.71033619
141MP0000377_abnormal_hair_follicle0.70960422
142MP0002132_abnormal_respiratory_system0.70636973
143MP0001944_abnormal_pancreas_morphology0.69010349
144MP0001440_abnormal_grooming_behavior0.68044625
145MP0009384_cardiac_valve_regurgitation0.64570967
146MP0002138_abnormal_hepatobiliary_system0.63606451
147MP0004782_abnormal_surfactant_physiolog0.61909822
148MP0003119_abnormal_digestive_system0.61245763
149MP0005647_abnormal_sex_gland0.59919889
150MP0002653_abnormal_ependyma_morphology0.59768306

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)3.92074205
2Decreased circulating renin level (HP:0003351)3.78629723
3Lip pit (HP:0100267)3.68942015
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.60959097
5Abnormality of the renal cortex (HP:0011035)3.57283458
6Hypoglycemic seizures (HP:0002173)3.39599823
7Hyperactive renin-angiotensin system (HP:0000841)3.39526369
8Parakeratosis (HP:0001036)3.38459052
9Pancreatic cysts (HP:0001737)3.18242813
10Abnormality of the renal medulla (HP:0100957)3.15671912
11Abnormality of the heme biosynthetic pathway (HP:0010472)3.11414324
12Intrahepatic cholestasis (HP:0001406)2.94074085
13Hyperaldosteronism (HP:0000859)2.92884474
14Nephronophthisis (HP:0000090)2.89963287
15Malnutrition (HP:0004395)2.88157187
16Hypochromic microcytic anemia (HP:0004840)2.88038587
17Hypobetalipoproteinemia (HP:0003563)2.87647069
18Poikilocytosis (HP:0004447)2.85362086
19Abnormal drinking behavior (HP:0030082)2.81105938
20Polydipsia (HP:0001959)2.81105938
21Abnormal hemoglobin (HP:0011902)2.76427756
22Deep venous thrombosis (HP:0002625)2.74500423
23Tubular atrophy (HP:0000092)2.70376328
24Acanthocytosis (HP:0001927)2.67610239
25Abnormal rod and cone electroretinograms (HP:0008323)2.67274684
26Onycholysis (HP:0001806)2.66546561
27Fragile nails (HP:0001808)2.65454704
28Curly hair (HP:0002212)2.65176785
29Hypothermia (HP:0002045)2.64231899
30Woolly hair (HP:0002224)2.63741421
31Abnormality of purine metabolism (HP:0004352)2.61609965
32Pancreatic fibrosis (HP:0100732)2.60481800
33Ileus (HP:0002595)2.58216842
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.57992067
35Hyperkalemia (HP:0002153)2.57677584
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.55580506
37Absent/shortened dynein arms (HP:0200106)2.55580506
38Abnormal respiratory motile cilium morphology (HP:0005938)2.54929589
39Abnormal respiratory epithelium morphology (HP:0012253)2.54929589
40Medial flaring of the eyebrow (HP:0010747)2.53892908
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.52994438
42Congenital sensorineural hearing impairment (HP:0008527)2.51806808
43True hermaphroditism (HP:0010459)2.51481185
44Conjugated hyperbilirubinemia (HP:0002908)2.48351406
45Tubulointerstitial nephritis (HP:0001970)2.48312894
46Renal salt wasting (HP:0000127)2.46752413
47Hyperbilirubinemia (HP:0002904)2.46454472
48Congenital ichthyosiform erythroderma (HP:0007431)2.45394055
49Hypokalemic alkalosis (HP:0001949)2.44574279
50Large for gestational age (HP:0001520)2.44487920
51Popliteal pterygium (HP:0009756)2.43359038
52Acute encephalopathy (HP:0006846)2.41568301
53Right ventricular cardiomyopathy (HP:0011663)2.39257852
54Abnormality of chloride homeostasis (HP:0011422)2.38906558
55Hyperglycinemia (HP:0002154)2.38318759
56Renal cortical cysts (HP:0000803)2.37812304
57Attenuation of retinal blood vessels (HP:0007843)2.37161861
58Abnormal gallbladder morphology (HP:0012437)2.36163372
59Gaze-evoked nystagmus (HP:0000640)2.35836071
60Xanthomatosis (HP:0000991)2.35062623
61Hyperglycinuria (HP:0003108)2.33386608
62Abnormality of urine glucose concentration (HP:0011016)2.31545384
63Glycosuria (HP:0003076)2.31545384
64Abnormal biliary tract morphology (HP:0012440)2.31281425
65Furrowed tongue (HP:0000221)2.31152055
66Abnormality of midbrain morphology (HP:0002418)2.31010822
67Molar tooth sign on MRI (HP:0002419)2.31010822
68Cholelithiasis (HP:0001081)2.30509454
69Chronic hepatic failure (HP:0100626)2.28000948
70Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27953745
71Hyperuricemia (HP:0002149)2.27325344
72Increased purine levels (HP:0004368)2.27325344
73Ketoacidosis (HP:0001993)2.25817509
74Hyperglycemia (HP:0003074)2.25348739
75Abnormal ciliary motility (HP:0012262)2.24367272
76Abnormal gallbladder physiology (HP:0012438)2.23702045
77Cholecystitis (HP:0001082)2.23702045
78Abnormality of sulfur amino acid metabolism (HP:0004339)2.21177964
79Stomach cancer (HP:0012126)2.21131381
80Ketosis (HP:0001946)2.20999540
81Abnormality of potassium homeostasis (HP:0011042)2.20938495
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20728979
83Cystic liver disease (HP:0006706)2.20213077
84Fat malabsorption (HP:0002630)2.18902326
85Widely spaced teeth (HP:0000687)2.18705129
86Rhinitis (HP:0012384)2.18257645
87Polyuria (HP:0000103)2.16881707
88Palmoplantar hyperkeratosis (HP:0000972)2.16668405
89Chronic bronchitis (HP:0004469)2.16259299
90Late onset (HP:0003584)2.13043231
91Genetic anticipation (HP:0003743)2.12969010
92Congenital stationary night blindness (HP:0007642)2.12840940
93Abnormality of vitamin B metabolism (HP:0004340)2.12652704
94Abnormal respiratory motile cilium physiology (HP:0012261)2.12544054
95Rickets (HP:0002748)2.12219438
96Abnormality of macular pigmentation (HP:0008002)2.11922471
97Palmar hyperkeratosis (HP:0010765)2.11898276
98Prolonged partial thromboplastin time (HP:0003645)2.11472086
99Absent eyebrow (HP:0002223)2.11395644
100Hypophosphatemic rickets (HP:0004912)2.11294420
101Metabolic acidosis (HP:0001942)2.10339766
102Generalized aminoaciduria (HP:0002909)2.08950393
103Metaphyseal dysplasia (HP:0100255)2.08882690
104Hypokalemia (HP:0002900)2.08199737
105Abnormality of the labia majora (HP:0012881)2.07951783
106Hyperphosphaturia (HP:0003109)2.06288017
107Symptomatic seizures (HP:0011145)2.05133732
108Septate vagina (HP:0001153)2.04893868
109Acute necrotizing encephalopathy (HP:0006965)2.03611525
110Abnormal urine output (HP:0012590)2.03104030
111Increased circulating renin level (HP:0000848)2.02412948
112Dehydration (HP:0001944)2.01478264
113Gait imbalance (HP:0002141)2.00171097
114Abnormality of nucleobase metabolism (HP:0010932)1.99701226
115Facial shape deformation (HP:0011334)1.99638900
116Potter facies (HP:0002009)1.99638900
117Bronchiectasis (HP:0002110)1.98904503
118Hyperinsulinemic hypoglycemia (HP:0000825)1.97837294
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97408455
120Brushfield spots (HP:0001088)1.97118840
121Intestinal atresia (HP:0011100)1.96721684
122Aplasia/hypoplasia of the uterus (HP:0008684)1.96652608
123Abnormality of glycine metabolism (HP:0010895)1.96456536
124Abnormality of serine family amino acid metabolism (HP:0010894)1.96456536
125Abolished electroretinogram (ERG) (HP:0000550)1.95671515
126Progressive cerebellar ataxia (HP:0002073)1.95343779
127Genital tract atresia (HP:0001827)1.95085581
128Exocrine pancreatic insufficiency (HP:0001738)1.94572780
129Labial hypoplasia (HP:0000066)1.94119035
130Congenital primary aphakia (HP:0007707)1.94041530
131Pili torti (HP:0003777)1.94012059
132Amelogenesis imperfecta (HP:0000705)1.93528423
133Osteomalacia (HP:0002749)1.93505025
134Tubulointerstitial abnormality (HP:0001969)1.93251175
135Cerebral edema (HP:0002181)1.91073089
136Abnormal pancreas size (HP:0012094)1.90619412
137Lethargy (HP:0001254)1.89588549
138Hypoplasia of the uterus (HP:0000013)1.89268980
139Hypolipoproteinemia (HP:0010981)1.88766825
140Abnormality of the axillary hair (HP:0100134)1.88404184
141Abnormality of secondary sexual hair (HP:0009888)1.88404184
142Epidermoid cyst (HP:0200040)1.88262112
143Tetany (HP:0001281)1.87901862
144Hyperlipoproteinemia (HP:0010980)1.85723647
145Nephrogenic diabetes insipidus (HP:0009806)1.84360834
146Fair hair (HP:0002286)1.84096591
147Vaginal atresia (HP:0000148)1.84021122
148Abnormality of the gallbladder (HP:0005264)1.83755903
149Syncope (HP:0001279)1.83384590
150Hepatocellular carcinoma (HP:0001402)1.82909836
151Plantar hyperkeratosis (HP:0007556)1.82602943
152Sex reversal (HP:0012245)1.81327542
153Abnormal sex determination (HP:0012244)1.81327542
154Hypoplastic labia majora (HP:0000059)1.81183906
155Abnormal hair laboratory examination (HP:0003328)1.80881255
156Abnormal urine phosphate concentration (HP:0012599)1.80465176
157Taurodontia (HP:0000679)1.80404820
158Abnormality of permanent molar morphology (HP:0011071)1.80404820
159Abnormality of the dental root (HP:0006486)1.80404820
160Tubulointerstitial fibrosis (HP:0005576)1.79536990
161Hypomagnesemia (HP:0002917)1.79395674
162Hypoplastic female external genitalia (HP:0012815)1.78877611
163Agitation (HP:0000713)1.77988117
164Vascular calcification (HP:0004934)1.75259125
165Hyperventilation (HP:0002883)1.74912330
166Abnormal mitochondria in muscle tissue (HP:0008316)1.74759396
167Vomiting (HP:0002013)1.74399422
168Metabolic alkalosis (HP:0200114)1.73334890
169Hyperammonemia (HP:0001987)1.72661671
170Abnormality of glycolysis (HP:0004366)1.71605440
171Increased serum pyruvate (HP:0003542)1.71605440
172Exotropia (HP:0000577)1.71352898
173Ventricular fibrillation (HP:0001663)1.69753666
174Widely patent fontanelles and sutures (HP:0004492)1.69053109
175Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.66657854
176Alkalosis (HP:0001948)1.66101276
177Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.63129978
178Abnormality of renal excretion (HP:0011036)1.62703143
179Hypotrichosis (HP:0001006)1.62431859
180Delusions (HP:0000746)1.62053256
181Abnormality of renin-angiotensin system (HP:0000847)1.61091845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB33.31720557
2FGFR23.23578205
3MAP3K23.16416684
4MST1R3.16245065
5MARK12.93204323
6STK38L2.76958445
7DYRK22.48226051
8CASK2.44123952
9LATS12.25646768
10LATS22.21824190
11MST42.21759417
12MAPKAPK32.18822262
13ACVR1B2.06828049
14PINK12.03690212
15MAP4K22.02650163
16BCR1.98093028
17GRK11.97242484
18NME11.94827392
19MAPK131.93530480
20BMPR21.91302610
21OXSR11.89982867
22ERBB41.89376134
23FER1.88019984
24ADRBK21.87277742
25FRK1.73163775
26TNIK1.72886924
27MAP2K71.71220102
28MAP3K41.68715114
29TESK11.66702778
30MAP3K31.65896216
31WNK41.64125541
32MAP3K91.62350408
33EPHB21.61100882
34NLK1.59562047
35FGFR31.58885758
36EPHA21.57625299
37LIMK11.51235468
38MAPK151.48856844
39GRK51.48458645
40MAP2K21.45418993
41WNK31.45354155
42PHKG21.37859708
43PHKG11.37859708
44MAP2K11.35112471
45PAK31.23825772
46STK391.23011472
47LMTK21.22100339
48KSR21.19939193
49MAP2K41.18420497
50DAPK21.13736628
51MINK11.09191671
52BMPR1B1.09153481
53PIK3CA1.08010297
54AKT31.07554405
55BCKDK1.05431574
56SGK4941.05033708
57SGK2231.05033708
58MAP3K121.04489408
59EPHA31.03631309
60CSNK1G21.01734316
61MAP3K60.99946688
62TAOK30.96871048
63BRAF0.94516486
64NEK60.94221908
65INSRR0.93003951
66TLK10.92955170
67NTRK30.92486155
68PASK0.91439267
69NUAK10.90682727
70TNK20.86604418
71ARAF0.85496041
72STK30.84155033
73AURKA0.83581832
74NTRK20.80967650
75RPS6KA20.78079047
76PBK0.77794926
77TGFBR10.75084411
78PRKD30.74747695
79PRKCI0.73265020
80STK380.72511297
81KSR10.72033273
82RPS6KB20.72032040
83SGK20.71935078
84GRK70.70237947
85MUSK0.69634987
86STK240.69335126
87MET0.68747073
88SIK30.62233419
89TEC0.61027651
90TRIM280.60188558
91DYRK1A0.59927894
92RET0.59797816
93MOS0.59777634
94PTK20.59067090
95MAP2K60.58900736
96PRKCZ0.58269375
97ADRBK10.57933020
98ITK0.57717625
99SGK30.56614017
100RPS6KB10.56324688
101MAP3K70.55568569
102TRPM70.54622719
103CDK50.52687535
104MYLK0.51904202
105CHUK0.51752136
106TAOK10.51669777
107PRKD20.50590067
108PRKCE0.50113228
109PRKAA20.50055072
110ERBB20.49697600
111PRKCQ0.49641985
112WNK10.49577576
113CAMKK20.49440637
114SGK10.49405107
115PTK60.48579171
116CSNK1G10.48260183
117CSNK1A10.48193110
118CSNK1G30.48163642
119KIT0.46456842
120CAMK2A0.46179538
121PLK20.46003751
122PTK2B0.45794267
123EPHA40.45673500
124CDK30.44387771
125MARK20.42621030
126CAMK2D0.41501389
127ABL20.40554366
128PRKG20.40367775
129PDK30.39910887
130PDK40.39910887
131EIF2AK30.39670026
132STK110.39635230
133ZAK0.39594118
134BRSK20.38958835
135HIPK20.38814161
136PRKG10.38746942
137EEF2K0.38654481
138PIK3CG0.38572336
139PRKAA10.38308152
140NTRK10.36413149
141CAMK2B0.35295545
142ROCK10.34822522
143CCNB10.32124227
144CDK180.31060900
145CDK140.30203642
146MAPKAPK50.29908150
147EIF2AK20.27759767
148PRKCG0.27220279

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.42672437
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73832969
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.69613969
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.56043745
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.35036990
6Butanoate metabolism_Homo sapiens_hsa006502.29481820
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.26729565
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.25319332
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.16855097
10Chemical carcinogenesis_Homo sapiens_hsa052042.09787529
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.01899695
12Collecting duct acid secretion_Homo sapiens_hsa049661.92921469
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83939758
14Oxidative phosphorylation_Homo sapiens_hsa001901.77372881
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76037199
16Tryptophan metabolism_Homo sapiens_hsa003801.71519174
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.69658316
18Nitrogen metabolism_Homo sapiens_hsa009101.68193294
19Fat digestion and absorption_Homo sapiens_hsa049751.67077311
20Pyruvate metabolism_Homo sapiens_hsa006201.65064771
21Histidine metabolism_Homo sapiens_hsa003401.60393103
22Fatty acid degradation_Homo sapiens_hsa000711.57584313
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55307940
24Glutathione metabolism_Homo sapiens_hsa004801.53083565
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48746925
26Peroxisome_Homo sapiens_hsa041461.41883325
27Propanoate metabolism_Homo sapiens_hsa006401.40426132
28Steroid biosynthesis_Homo sapiens_hsa001001.39023841
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37980138
30Retinol metabolism_Homo sapiens_hsa008301.36014435
31Folate biosynthesis_Homo sapiens_hsa007901.34261709
32Phenylalanine metabolism_Homo sapiens_hsa003601.34090865
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33984296
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.31447974
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31061982
36Linoleic acid metabolism_Homo sapiens_hsa005911.29550316
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29272206
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28613923
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.28539446
40beta-Alanine metabolism_Homo sapiens_hsa004101.18306912
41Vibrio cholerae infection_Homo sapiens_hsa051101.18253412
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.18205713
43Selenocompound metabolism_Homo sapiens_hsa004501.16578420
44Bile secretion_Homo sapiens_hsa049761.15643613
45Dorso-ventral axis formation_Homo sapiens_hsa043201.13546183
46Mineral absorption_Homo sapiens_hsa049781.11339420
47Tyrosine metabolism_Homo sapiens_hsa003501.11125490
48Parkinsons disease_Homo sapiens_hsa050121.09792542
49Arginine biosynthesis_Homo sapiens_hsa002201.09282381
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07724525
51Renin secretion_Homo sapiens_hsa049241.06629468
52Vitamin digestion and absorption_Homo sapiens_hsa049771.01739002
53Synaptic vesicle cycle_Homo sapiens_hsa047211.01604351
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99818962
55Alzheimers disease_Homo sapiens_hsa050100.99576328
56Type I diabetes mellitus_Homo sapiens_hsa049400.98765824
57Fatty acid metabolism_Homo sapiens_hsa012120.95618091
58Sphingolipid metabolism_Homo sapiens_hsa006000.94071191
59Salivary secretion_Homo sapiens_hsa049700.93569782
60Ovarian steroidogenesis_Homo sapiens_hsa049130.92330582
61ABC transporters_Homo sapiens_hsa020100.86536946
62PPAR signaling pathway_Homo sapiens_hsa033200.85513898
63Fatty acid elongation_Homo sapiens_hsa000620.85296573
64Sulfur relay system_Homo sapiens_hsa041220.84820689
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84398834
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82905502
67Arachidonic acid metabolism_Homo sapiens_hsa005900.82152535
68Glycerolipid metabolism_Homo sapiens_hsa005610.81914295
69Circadian entrainment_Homo sapiens_hsa047130.79104492
70Bladder cancer_Homo sapiens_hsa052190.76401215
71Protein export_Homo sapiens_hsa030600.75197486
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75016948
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73850871
74Huntingtons disease_Homo sapiens_hsa050160.73709162
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73315318
76Caffeine metabolism_Homo sapiens_hsa002320.71330405
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71218588
78Glutamatergic synapse_Homo sapiens_hsa047240.69042229
79Pancreatic secretion_Homo sapiens_hsa049720.67668496
80Metabolic pathways_Homo sapiens_hsa011000.66670386
81Type II diabetes mellitus_Homo sapiens_hsa049300.66508613
82Starch and sucrose metabolism_Homo sapiens_hsa005000.66171691
83Complement and coagulation cascades_Homo sapiens_hsa046100.63393155
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.62947453
85Fatty acid biosynthesis_Homo sapiens_hsa000610.61870427
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.61289215
87Protein digestion and absorption_Homo sapiens_hsa049740.58660775
88Insulin secretion_Homo sapiens_hsa049110.58124460
89Ether lipid metabolism_Homo sapiens_hsa005650.57866475
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57126496
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57089234
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56966380
93Vitamin B6 metabolism_Homo sapiens_hsa007500.55957304
94Tight junction_Homo sapiens_hsa045300.55422909
95Taste transduction_Homo sapiens_hsa047420.55357724
96Serotonergic synapse_Homo sapiens_hsa047260.55085910
97Long-term depression_Homo sapiens_hsa047300.54896579
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52856657
99Gastric acid secretion_Homo sapiens_hsa049710.51587770
100Cocaine addiction_Homo sapiens_hsa050300.49487481
101Phototransduction_Homo sapiens_hsa047440.48113419
102Dopaminergic synapse_Homo sapiens_hsa047280.47372599
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46604174
104Renin-angiotensin system_Homo sapiens_hsa046140.46427927
105Arginine and proline metabolism_Homo sapiens_hsa003300.45751074
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.44304775
107Insulin resistance_Homo sapiens_hsa049310.44242363
108Glucagon signaling pathway_Homo sapiens_hsa049220.42552957
109Inositol phosphate metabolism_Homo sapiens_hsa005620.41127529
110Regulation of autophagy_Homo sapiens_hsa041400.40364551
111Axon guidance_Homo sapiens_hsa043600.40056393
112GABAergic synapse_Homo sapiens_hsa047270.39822485
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38223490
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.37589274
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37114999
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37056198
117Amphetamine addiction_Homo sapiens_hsa050310.36796464
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36247767
119Circadian rhythm_Homo sapiens_hsa047100.35865205
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35030907
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34846652
122Nicotine addiction_Homo sapiens_hsa050330.34549474
123Carbon metabolism_Homo sapiens_hsa012000.34335603
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34294082
125Calcium signaling pathway_Homo sapiens_hsa040200.34116243
126Morphine addiction_Homo sapiens_hsa050320.33571817
127Thyroid hormone synthesis_Homo sapiens_hsa049180.33471406
128cAMP signaling pathway_Homo sapiens_hsa040240.33186894
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32519554
130Endometrial cancer_Homo sapiens_hsa052130.32206415
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32083550
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29178058
133Cholinergic synapse_Homo sapiens_hsa047250.28589206

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