SH3GLB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.46521613
2synaptic vesicle maturation (GO:0016188)5.43299521
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.06002769
4locomotory exploration behavior (GO:0035641)4.98224725
5synaptic vesicle exocytosis (GO:0016079)4.92070986
6glutamate secretion (GO:0014047)4.85868753
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.82810093
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.81572338
9vocalization behavior (GO:0071625)4.62142158
10neuronal action potential propagation (GO:0019227)4.58782669
11cytoskeletal anchoring at plasma membrane (GO:0007016)4.57947160
12regulation of synaptic vesicle exocytosis (GO:2000300)4.54387110
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.47300916
14regulation of glutamate receptor signaling pathway (GO:1900449)4.26415613
15regulation of ARF protein signal transduction (GO:0032012)4.25544197
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.19740679
17regulation of synapse structural plasticity (GO:0051823)4.13119497
18regulation of synaptic vesicle transport (GO:1902803)4.05615213
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.02054764
20mannose metabolic process (GO:0006013)4.00478180
21neurotransmitter secretion (GO:0007269)3.98848865
22regulation of neuronal synaptic plasticity (GO:0048168)3.95774072
23semaphorin-plexin signaling pathway (GO:0071526)3.93888569
24protein localization to synapse (GO:0035418)3.93332425
25peptidyl-tyrosine autophosphorylation (GO:0038083)3.90162199
26activation of protein kinase A activity (GO:0034199)3.85978909
27negative regulation of erythrocyte differentiation (GO:0045647)3.85421499
28cellular potassium ion homeostasis (GO:0030007)3.73198756
29exploration behavior (GO:0035640)3.72740802
30negative regulation of cell size (GO:0045792)3.72430661
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.70567895
32sodium ion export (GO:0071436)3.70295366
33regulation of ARF GTPase activity (GO:0032312)3.69850561
34glutamate receptor signaling pathway (GO:0007215)3.67798375
35synaptic transmission, glutamatergic (GO:0035249)3.66043795
36desmosome organization (GO:0002934)3.64787978
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.64321678
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.64145207
39neuron cell-cell adhesion (GO:0007158)3.63772779
40activation of Rac GTPase activity (GO:0032863)3.57455487
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.56914051
42neurotransmitter-gated ion channel clustering (GO:0072578)3.55580767
43neuron-neuron synaptic transmission (GO:0007270)3.50241933
44membrane depolarization during action potential (GO:0086010)3.47789563
45cell communication by electrical coupling (GO:0010644)3.45559700
46layer formation in cerebral cortex (GO:0021819)3.43649598
47cerebellar granule cell differentiation (GO:0021707)3.43640222
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39371503
49gamma-aminobutyric acid transport (GO:0015812)3.38327444
50proline transport (GO:0015824)3.37533572
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36124811
52glycine transport (GO:0015816)3.35930468
53long-term memory (GO:0007616)3.33461039
54adherens junction assembly (GO:0034333)3.33117719
55dendritic spine morphogenesis (GO:0060997)3.32099919
56regulation of synaptic plasticity (GO:0048167)3.31607815
57neuromuscular process controlling posture (GO:0050884)3.30896156
58positive regulation of membrane potential (GO:0045838)3.26075332
59transmission of nerve impulse (GO:0019226)3.24466884
60negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.24158846
61neurotransmitter transport (GO:0006836)3.23700011
62cerebellar Purkinje cell differentiation (GO:0021702)3.23197840
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.20980595
64regulation of postsynaptic membrane potential (GO:0060078)3.20443892
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.19299739
66cell-substrate adherens junction assembly (GO:0007045)3.19297590
67focal adhesion assembly (GO:0048041)3.19297590
68neuromuscular process controlling balance (GO:0050885)3.17281449
69synaptic vesicle endocytosis (GO:0048488)3.16904188
70cell-cell junction maintenance (GO:0045217)3.16737460
71adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.16608959
72positive regulation of synapse maturation (GO:0090129)3.15692912
73prepulse inhibition (GO:0060134)3.10762860
74neuronal ion channel clustering (GO:0045161)3.10105475
75regulation of dendritic spine morphogenesis (GO:0061001)3.09914036
76maternal placenta development (GO:0001893)3.09579449
77regulation of neurotransmitter secretion (GO:0046928)3.09253376
78retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.09109777
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.08841918
80membrane depolarization (GO:0051899)3.08017462
81regulation of vesicle fusion (GO:0031338)3.07272108
82epithelial cell differentiation involved in prostate gland development (GO:0060742)3.06915383
83regulation of synaptic transmission, glutamatergic (GO:0051966)3.06614283
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06095218
85regulation of voltage-gated calcium channel activity (GO:1901385)3.05979557
86regulation of synapse maturation (GO:0090128)3.04856655
87planar cell polarity pathway involved in neural tube closure (GO:0090179)3.03924210
88myelin maintenance (GO:0043217)3.03440773
89G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03020545
90regulation of neurotransmitter levels (GO:0001505)3.01864446
91long-term synaptic potentiation (GO:0060291)3.01481920
92cell migration in hindbrain (GO:0021535)2.99708821
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.98968929
94membrane hyperpolarization (GO:0060081)2.97624362
95positive regulation of Cdc42 GTPase activity (GO:0043089)2.97284533
96neuron recognition (GO:0008038)2.96551393
97dopamine receptor signaling pathway (GO:0007212)2.94743738
98Golgi transport vesicle coating (GO:0048200)2.93708071
99COPI coating of Golgi vesicle (GO:0048205)2.93708071
100auditory behavior (GO:0031223)2.93122277
101positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.92592625
102positive regulation of neurotransmitter transport (GO:0051590)2.91846045
103endothelial cell chemotaxis (GO:0035767)2.91591992
104potassium ion homeostasis (GO:0055075)2.90578702
105response to auditory stimulus (GO:0010996)2.90461118
106regulation of neurotransmitter transport (GO:0051588)2.89958993
107negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89664315
108regulation of glucose import in response to insulin stimulus (GO:2001273)2.89006568
109cell communication involved in cardiac conduction (GO:0086065)2.87180880
110positive regulation of neurotransmitter secretion (GO:0001956)2.87009831
111regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86874564
112cellular sodium ion homeostasis (GO:0006883)2.85350957
113behavioral response to cocaine (GO:0048148)2.85072436
114negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83533032
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83421509
116regulation of early endosome to late endosome transport (GO:2000641)2.83228394
117axonal fasciculation (GO:0007413)2.82697579
118gamma-aminobutyric acid signaling pathway (GO:0007214)2.82669256
119ear development (GO:0043583)2.82516568
120regulation of synaptic transmission (GO:0050804)2.81370759
121dendrite morphogenesis (GO:0048813)2.81282524
122potassium ion import (GO:0010107)2.80458116
123positive regulation of synaptic transmission (GO:0050806)2.77691108
124mating behavior (GO:0007617)2.77633448
125membrane repolarization (GO:0086009)2.77293588
126synaptic transmission (GO:0007268)2.77237456
127positive regulation of protein dephosphorylation (GO:0035307)2.76703739
128negative regulation of dendrite morphogenesis (GO:0050774)2.75253316
129regulation of histone H3-K27 methylation (GO:0061085)2.75097175
130insulin-like growth factor receptor signaling pathway (GO:0048009)2.75050578
131vesicle transport along microtubule (GO:0047496)2.74875411
132protein localization to endosome (GO:0036010)2.74702308
133long term synaptic depression (GO:0060292)2.74190001
134dendritic spine organization (GO:0097061)2.73229456
135apoptotic process involved in morphogenesis (GO:0060561)2.72996075
136protein retention in ER lumen (GO:0006621)2.71410350
137signal complex assembly (GO:0007172)2.70006710
138protein targeting to plasma membrane (GO:0072661)2.67920113
139positive regulation of Rap GTPase activity (GO:0032854)2.66791956
140regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.65113497
141regulation of mammary gland epithelial cell proliferation (GO:0033599)2.64621371
142L-amino acid import (GO:0043092)2.62998758
143activation of MAPKKK activity (GO:0000185)2.62941606
144amino acid import (GO:0043090)2.60834345
145activation of JUN kinase activity (GO:0007257)2.60446425
146regulation of cholesterol biosynthetic process (GO:0045540)2.57320936
147regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.54402937
148histone H4 deacetylation (GO:0070933)2.52143030
149cell volume homeostasis (GO:0006884)2.50012839
150positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.48828376
151cell-substrate junction assembly (GO:0007044)2.48731526
152regulation of water loss via skin (GO:0033561)2.46976216
153positive regulation of receptor recycling (GO:0001921)2.46462143
154positive regulation of histone deacetylation (GO:0031065)2.43989284
155regulation of fatty acid beta-oxidation (GO:0031998)2.42314688
156maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41699764
157regulation of clathrin-mediated endocytosis (GO:2000369)2.40500179
158intracellular estrogen receptor signaling pathway (GO:0030520)2.39200830
159positive regulation of protein kinase C signaling (GO:0090037)2.38969440
160thymic T cell selection (GO:0045061)2.38788548
161negative regulation of myotube differentiation (GO:0010832)2.37930324
162epithelial cell-cell adhesion (GO:0090136)2.37047942
163proline biosynthetic process (GO:0006561)2.36173869
164regulation of cholesterol metabolic process (GO:0090181)2.34088067
165atrioventricular valve morphogenesis (GO:0003181)2.31512400
166establishment of protein localization to plasma membrane (GO:0090002)2.31478122
167multicellular organismal water homeostasis (GO:0050891)2.31092951
168cell junction maintenance (GO:0034331)2.30597238
169negative regulation of fatty acid transport (GO:2000192)2.30163991
170regulation of hydrogen peroxide metabolic process (GO:0010310)2.29686564
171lung epithelium development (GO:0060428)2.26725787
172positive regulation of Rac GTPase activity (GO:0032855)2.25446481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.74787213
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15821881
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12680951
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.04081253
5GBX2_23144817_ChIP-Seq_PC3_Human2.99490081
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98362280
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.88461810
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.88461810
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.87482302
10DROSHA_22980978_ChIP-Seq_HELA_Human2.83100102
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80813783
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.69742428
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65966061
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65351413
15REST_21632747_ChIP-Seq_MESCs_Mouse2.60399324
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58692784
17RACK7_27058665_Chip-Seq_MCF-7_Human2.56205932
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56153451
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48215043
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.44335765
21VDR_21846776_ChIP-Seq_THP-1_Human2.39163703
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38432800
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.36518708
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35477455
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.34149877
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.32440384
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31466876
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.31052252
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.27898484
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.26439838
31KDM2B_26808549_Chip-Seq_DND41_Human2.23631451
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21366701
33ELK3_25401928_ChIP-Seq_HUVEC_Human2.19743501
34TCF7_22412390_ChIP-Seq_EML_Mouse2.15921441
35MYC_22102868_ChIP-Seq_BL_Human2.05112103
36P68_20966046_ChIP-Seq_HELA_Human1.97314558
37ZNF263_19887448_ChIP-Seq_K562_Human1.95479518
38* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94061214
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.89289167
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87951336
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83400619
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.79598581
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78010611
44CREB1_26743006_Chip-Seq_LNCaP_Human1.74740439
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.69036806
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.68875437
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.66843443
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.62428001
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.60313959
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59347324
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59089514
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58468764
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57203271
54CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.56501698
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.56071776
56* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.53054714
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46791221
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46350008
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45022450
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44564880
61KDM2B_26808549_Chip-Seq_K562_Human1.43982597
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43404541
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39295968
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.38960102
65AR_21572438_ChIP-Seq_LNCaP_Human1.38002005
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37713964
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37522186
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35113554
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32234135
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32037380
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31789586
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30848288
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29841079
74SMAD4_21799915_ChIP-Seq_A2780_Human1.29006017
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28844609
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27453895
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26367288
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25612245
79* BCOR_27268052_Chip-Seq_Bcells_Human1.25277896
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23706398
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22852104
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22729618
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22381456
84* TP63_22573176_ChIP-Seq_HFKS_Human1.20944496
85MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20346661
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.19915455
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19538200
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18078277
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17904252
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16218981
91MAF_26560356_Chip-Seq_TH2_Human1.15590466
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.15208980
93* VDR_24763502_ChIP-Seq_THP-1_Human1.13755551
94AR_19668381_ChIP-Seq_PC3_Human1.13297334
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13179288
96ZNF274_21170338_ChIP-Seq_K562_Hela1.12141195
97TAF15_26573619_Chip-Seq_HEK293_Human1.11389853
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11029377
99CTCF_27219007_Chip-Seq_Bcells_Human1.10016553
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.09478275
101MAF_26560356_Chip-Seq_TH1_Human1.09336599
102* BCL6_27268052_Chip-Seq_Bcells_Human1.08610802
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08486553
104* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08322410
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08285152
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07433578
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07063211
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.06422627
109AHR_22903824_ChIP-Seq_MCF-7_Human1.06056812
110TET1_21490601_ChIP-Seq_MESCs_Mouse1.05770685
111NCOR1_26117541_ChIP-Seq_K562_Human1.05548747
112SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05382583
113CLOCK_20551151_ChIP-Seq_293T_Human1.05374773
114SA1_27219007_Chip-Seq_Bcells_Human1.03378191
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02784241
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02513040
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02456165
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01560963
119ATF3_27146783_Chip-Seq_COLON_Human1.01263277
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00222871
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99894742
122RARB_24833708_ChIP-Seq_LIVER_Mouse0.99359508
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99010930
124STAT3_23295773_ChIP-Seq_U87_Human0.98927112
125* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98863234
126TP53_22127205_ChIP-Seq_IMR90_Human0.98515436
127PHF8_20622854_ChIP-Seq_HELA_Human0.98501370
128OCT4_19829295_ChIP-Seq_ESCs_Human0.98471875
129AR_25329375_ChIP-Seq_VCAP_Human0.97209698
130RUNX1_22412390_ChIP-Seq_EML_Mouse0.96860607
131KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96614821
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.96489599
133BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96486616
134UTX_26944678_Chip-Seq_JUKART_Human0.96127387
135* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95884090
136PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95627956
137E2F1_20622854_ChIP-Seq_HELA_Human0.95476074
138LXR_22292898_ChIP-Seq_THP-1_Human0.95416889
139TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95400193
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95109015
141GATA1_19941826_ChIP-Seq_K562_Human0.93847513
142TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91838887
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.89906709
144* SMC4_20622854_ChIP-Seq_HELA_Human0.89757607
145P300_19829295_ChIP-Seq_ESCs_Human0.89303581
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88837499
147CBX2_27304074_Chip-Seq_ESCs_Mouse0.88140536
148ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88122963
149EP300_21415370_ChIP-Seq_HL-1_Mouse0.88093613
150VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87418045
151SMAD3_21741376_ChIP-Seq_EPCs_Human0.87210554
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.86932873
153SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86911736
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.85953254
155ESR2_21235772_ChIP-Seq_MCF-7_Human0.85292510
156YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84793686
157ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84747540
158KLF4_19829295_ChIP-Seq_ESCs_Human0.84599041
159SMAD_19615063_ChIP-ChIP_OVARY_Human0.84593827
160RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83996079
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83964358
162TP53_20018659_ChIP-ChIP_R1E_Mouse0.83513100
163MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83327621
164ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83302135
165OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83205260
166GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82914560
167TCF4_23295773_ChIP-Seq_U87_Human0.82829347
168TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82662874
169ESR1_20079471_ChIP-ChIP_T-47D_Human0.81997912
170DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81803634
171PRDM14_20953172_ChIP-Seq_ESCs_Human0.79075725

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.24092298
2MP0003705_abnormal_hypodermis_morpholog4.83562397
3MP0003880_abnormal_central_pattern4.27905196
4MP0003635_abnormal_synaptic_transmissio3.95619828
5MP0004270_analgesia3.68457888
6MP0009745_abnormal_behavioral_response3.18517296
7MP0002822_catalepsy3.10460350
8MP0001968_abnormal_touch/_nociception3.08461962
9MP0002063_abnormal_learning/memory/cond3.05978958
10MP0002064_seizures2.97682706
11MP0005409_darkened_coat_color2.94204658
12MP0009046_muscle_twitch2.80173276
13MP0002272_abnormal_nervous_system2.73956956
14MP0005058_abnormal_lysosome_morphology2.61889976
15MP0002734_abnormal_mechanical_nocicepti2.60825056
16MP0001849_ear_inflammation2.60368004
17MP0002572_abnormal_emotion/affect_behav2.55143030
18MP0002796_impaired_skin_barrier2.54863926
19MP0002736_abnormal_nociception_after2.54390717
20MP0005076_abnormal_cell_differentiation2.52278888
21MP0002735_abnormal_chemical_nociception2.47864632
22MP0005423_abnormal_somatic_nervous2.42765069
23MP0001486_abnormal_startle_reflex2.37103938
24MP0002249_abnormal_larynx_morphology2.31875484
25MP0008260_abnormal_autophagy2.27874837
26MP0001501_abnormal_sleep_pattern2.26883516
27MP0003172_abnormal_lysosome_physiology2.16871182
28MP0004858_abnormal_nervous_system2.15343767
29MP0000678_abnormal_parathyroid_gland2.15296322
30MP0002733_abnormal_thermal_nociception2.13693044
31MP0001348_abnormal_lacrimal_gland2.11687915
32MP0004381_abnormal_hair_follicle2.10687330
33MP0001970_abnormal_pain_threshold2.05423154
34MP0001984_abnormal_olfaction2.05411038
35MP0004264_abnormal_extraembryonic_tissu2.03225505
36MP0003453_abnormal_keratinocyte_physiol1.98262209
37MP0008569_lethality_at_weaning1.98098619
38MP0001440_abnormal_grooming_behavior1.96234247
39MP0003329_amyloid_beta_deposits1.93487886
40MP0002067_abnormal_sensory_capabilities1.92456564
41MP0002909_abnormal_adrenal_gland1.91002945
42MP0002184_abnormal_innervation1.88351981
43MP0000566_synostosis1.83092575
44MP0004185_abnormal_adipocyte_glucose1.74662567
45MP0009780_abnormal_chondrocyte_physiolo1.72909231
46MP0000751_myopathy1.71996372
47MP0003183_abnormal_peptide_metabolism1.71978963
48MP0000013_abnormal_adipose_tissue1.71178306
49MP0006276_abnormal_autonomic_nervous1.70373493
50MP0005451_abnormal_body_composition1.70004630
51MP0004811_abnormal_neuron_physiology1.66081635
52MP0003879_abnormal_hair_cell1.64345380
53MP0005645_abnormal_hypothalamus_physiol1.64113918
54MP0005501_abnormal_skin_physiology1.63906531
55MP0003123_paternal_imprinting1.61027307
56MP0002837_dystrophic_cardiac_calcinosis1.59089000
57MP0005386_behavior/neurological_phenoty1.57915848
58MP0004924_abnormal_behavior1.57915848
59MP0002557_abnormal_social/conspecific_i1.56336348
60MP0000955_abnormal_spinal_cord1.52923303
61MP0000579_abnormal_nail_morphology1.48588920
62MP0000778_abnormal_nervous_system1.45504598
63MP0005666_abnormal_adipose_tissue1.45494764
64MP0004947_skin_inflammation1.42525869
65MP0004142_abnormal_muscle_tone1.41142806
66MP0003191_abnormal_cellular_cholesterol1.39266514
67MP0002882_abnormal_neuron_morphology1.39223490
68MP0002066_abnormal_motor_capabilities/c1.38376790
69MP0005646_abnormal_pituitary_gland1.38121736
70MP0002098_abnormal_vibrissa_morphology1.36808588
71MP0003633_abnormal_nervous_system1.34165763
72MP0009278_abnormal_bone_marrow1.33739976
73MP0001958_emphysema1.30247354
74MP0004885_abnormal_endolymph1.29110882
75MP0002089_abnormal_postnatal_growth/wei1.29040392
76MP0003566_abnormal_cell_adhesion1.24489048
77MP0005377_hearing/vestibular/ear_phenot1.24122251
78MP0003878_abnormal_ear_physiology1.24122251
79MP0004145_abnormal_muscle_electrophysio1.22753628
80MP0001502_abnormal_circadian_rhythm1.22380256
81MP0001529_abnormal_vocalization1.19116590
82MP0001346_abnormal_lacrimal_gland1.17866794
83MP0001905_abnormal_dopamine_level1.14346164
84MP0003283_abnormal_digestive_organ1.09514138
85MP0000537_abnormal_urethra_morphology1.08284861
86MP0003631_nervous_system_phenotype1.06918644
87MP0008872_abnormal_physiological_respon1.05677314
88MP0003303_peritoneal_inflammation1.04902319
89MP0001765_abnormal_ion_homeostasis1.04241113
90MP0004130_abnormal_muscle_cell1.03744780
91MP0000681_abnormal_thyroid_gland1.03437390
92MP0001485_abnormal_pinna_reflex1.02180559
93MP0004215_abnormal_myocardial_fiber1.01463658
94MP0004085_abnormal_heartbeat0.99530842
95MP0002069_abnormal_eating/drinking_beha0.99107318
96MP0008961_abnormal_basal_metabolism0.99041454
97MP0009384_cardiac_valve_regurgitation0.98849806
98MP0005535_abnormal_body_temperature0.98398209
99MP0002229_neurodegeneration0.97867246
100MP0002152_abnormal_brain_morphology0.97588481
101MP0009840_abnormal_foam_cell0.97400717
102MP0001873_stomach_inflammation0.97227972
103MP0003122_maternal_imprinting0.97131732
104MP0000003_abnormal_adipose_tissue0.96400665
105MP0008874_decreased_physiological_sensi0.96393014
106MP0000462_abnormal_digestive_system0.93996162
107MP0003091_abnormal_cell_migration0.93759131
108MP0003787_abnormal_imprinting0.92533680
109MP0003634_abnormal_glial_cell0.89940808
110MP0009931_abnormal_skin_appearance0.89250652
111MP0003075_altered_response_to0.88720085
112MP0000467_abnormal_esophagus_morphology0.88285281
113MP0003690_abnormal_glial_cell0.86268029
114MP0010771_integument_phenotype0.86202525
115MP0000377_abnormal_hair_follicle0.86093752
116MP0005167_abnormal_blood-brain_barrier0.85780579
117MP0000920_abnormal_myelination0.85159487
118MP0002060_abnormal_skin_morphology0.84403437
119MP0004742_abnormal_vestibular_system0.81749178
120MP0003045_fibrosis0.81675590
121MP0003137_abnormal_impulse_conducting0.81412574
122MP0000604_amyloidosis0.80671707
123MP0001664_abnormal_digestion0.79800820
124MP0005499_abnormal_olfactory_system0.79243560
125MP0005394_taste/olfaction_phenotype0.79243560
126MP0004036_abnormal_muscle_relaxation0.77941293
127MP0002752_abnormal_somatic_nervous0.76141452
128MP0000747_muscle_weakness0.76130429
129MP0002877_abnormal_melanocyte_morpholog0.75959067
130MP0000733_abnormal_muscle_development0.75388482
131MP0002876_abnormal_thyroid_physiology0.75101226
132MP0001177_atelectasis0.74062788
133MP0001216_abnormal_epidermal_layer0.73583055
134MP0010678_abnormal_skin_adnexa0.73403461
135MP0001963_abnormal_hearing_physiology0.71600880
136MP0003436_decreased_susceptibility_to0.71557311
137MP0010386_abnormal_urinary_bladder0.70864528
138MP0003646_muscle_fatigue0.69781974
139MP0002896_abnormal_bone_mineralization0.68708152
140MP0005623_abnormal_meninges_morphology0.68531485
141MP0004484_altered_response_of0.68242083
142MP0006138_congestive_heart_failure0.68012320
143MP0004782_abnormal_surfactant_physiolog0.66937408
144MP0005620_abnormal_muscle_contractility0.66869244
145MP0010234_abnormal_vibrissa_follicle0.66325725
146MP0002090_abnormal_vision0.66142198
147MP0003279_aneurysm0.64914725
148MP0005551_abnormal_eye_electrophysiolog0.63971315
149MP0003632_abnormal_nervous_system0.62884370
150MP0001188_hyperpigmentation0.62503880
151MP0000749_muscle_degeneration0.61228404
152MP0009672_abnormal_birth_weight0.61016889
153MP0002653_abnormal_ependyma_morphology0.59483380
154MP0005166_decreased_susceptibility_to0.59212065
155MP0004233_abnormal_muscle_weight0.58991690
156MP0005083_abnormal_biliary_tract0.58201065
157MP0000858_altered_metastatic_potential0.57771205
158MP0005375_adipose_tissue_phenotype0.57618746
159MP0005621_abnormal_cell_physiology0.57449486
160MP0010030_abnormal_orbit_morphology0.56167410
161MP0003866_abnormal_defecation0.56153525
162MP0004043_abnormal_pH_regulation0.54997894
163MP0000534_abnormal_ureter_morphology0.54816427
164MP0004510_myositis0.54134989
165MP0005670_abnormal_white_adipose0.53518140

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.19207005
2Focal motor seizures (HP:0011153)6.79780665
3Focal seizures (HP:0007359)5.38487962
4Obstructive sleep apnea (HP:0002870)5.04995834
5Visual hallucinations (HP:0002367)4.89182839
6Atonic seizures (HP:0010819)4.52822842
7Febrile seizures (HP:0002373)4.28565277
8Action tremor (HP:0002345)4.13257972
9Epileptic encephalopathy (HP:0200134)3.99253057
10Supranuclear gaze palsy (HP:0000605)3.85038395
11Broad face (HP:0000283)3.67023473
12Absence seizures (HP:0002121)3.63437226
13Progressive cerebellar ataxia (HP:0002073)3.58945955
14J-shaped sella turcica (HP:0002680)3.47460845
15Generalized tonic-clonic seizures (HP:0002069)3.45491180
16Ankle clonus (HP:0011448)3.43829060
17Hyperacusis (HP:0010780)3.40749980
18Dialeptic seizures (HP:0011146)3.36637912
19Thin bony cortex (HP:0002753)3.35107554
20Depression (HP:0000716)3.12873285
21Abnormality of the lower motor neuron (HP:0002366)3.09925847
22Poor eye contact (HP:0000817)3.08736821
23Cerebral aneurysm (HP:0004944)3.06286988
24Stridor (HP:0010307)3.01472087
25Anxiety (HP:0000739)3.01122893
26Dysmetria (HP:0001310)2.99147139
27Ventricular fibrillation (HP:0001663)2.95495013
28Impaired social interactions (HP:0000735)2.94079046
29Abnormal social behavior (HP:0012433)2.94079046
30Pheochromocytoma (HP:0002666)2.91220962
31Impaired vibration sensation in the lower limbs (HP:0002166)2.87548192
32Abnormal eating behavior (HP:0100738)2.86600982
33Truncal ataxia (HP:0002078)2.85344525
34Dysdiadochokinesis (HP:0002075)2.84990907
35Gaze-evoked nystagmus (HP:0000640)2.82436019
36Amblyopia (HP:0000646)2.79006330
37Broad-based gait (HP:0002136)2.74277141
38Distal upper limb amyotrophy (HP:0007149)2.73117163
39Upper limb amyotrophy (HP:0009129)2.73117163
40Cervical subluxation (HP:0003308)2.71981287
41Torticollis (HP:0000473)2.67001419
42Urinary urgency (HP:0000012)2.64540428
43Hemiplegia (HP:0002301)2.64516713
44Urinary bladder sphincter dysfunction (HP:0002839)2.64426053
45Flat acetabular roof (HP:0003180)2.62472316
46Scanning speech (HP:0002168)2.60798244
47Termporal pattern (HP:0011008)2.58157377
48Insidious onset (HP:0003587)2.58157377
49Postural instability (HP:0002172)2.55974396
50Bronchomalacia (HP:0002780)2.54074662
51Neuroendocrine neoplasm (HP:0100634)2.51481386
52Focal dystonia (HP:0004373)2.51068157
53Intention tremor (HP:0002080)2.50196715
54Spastic gait (HP:0002064)2.48652762
55Distal lower limb amyotrophy (HP:0008944)2.44602497
56Bundle branch block (HP:0011710)2.44174423
57Lymphangioma (HP:0100764)2.42406747
58Annular pancreas (HP:0001734)2.41968644
59Shallow orbits (HP:0000586)2.39550026
60Neurofibrillary tangles (HP:0002185)2.39168285
61Hyperparathyroidism (HP:0000843)2.38520186
62Status epilepticus (HP:0002133)2.37595798
63Cerebral inclusion bodies (HP:0100314)2.35875279
64Distal lower limb muscle weakness (HP:0009053)2.34012857
65Turricephaly (HP:0000262)2.33216532
66Germ cell neoplasia (HP:0100728)2.31479285
67Sudden death (HP:0001699)2.31313177
68Insomnia (HP:0100785)2.30793196
69Craniofacial dystonia (HP:0012179)2.29495444
70Impaired smooth pursuit (HP:0007772)2.28693896
71Hemiparesis (HP:0001269)2.28372660
72Dysmetric saccades (HP:0000641)2.25857687
73Syncope (HP:0001279)2.25172615
74Anosmia (HP:0000458)2.24355781
75Prolonged QT interval (HP:0001657)2.23083488
76Nuclear cataract (HP:0100018)2.22681612
77Lower limb muscle weakness (HP:0007340)2.21851096
78Abnormal EKG (HP:0003115)2.20885996
79Megalencephaly (HP:0001355)2.18722164
80Stereotypic behavior (HP:0000733)2.18531266
81Retinal dysplasia (HP:0007973)2.18000489
82Progressive inability to walk (HP:0002505)2.17481226
83Limb dystonia (HP:0002451)2.15273459
84Metaphyseal cupping (HP:0003021)2.15127510
85Dysostosis multiplex (HP:0000943)2.14912181
86Increased connective tissue (HP:0009025)2.13353333
87Rapidly progressive (HP:0003678)2.13141838
88Pointed chin (HP:0000307)2.12184981
89Hypercortisolism (HP:0001578)2.11100877
90Abnormality of the fingertips (HP:0001211)2.10838347
91Myotonia (HP:0002486)2.09060391
92Deformed sella turcica (HP:0002681)2.08454569
93Ulnar bowing (HP:0003031)2.07533775
94Mutism (HP:0002300)2.07192576
95Genetic anticipation (HP:0003743)2.07071782
96Failure to thrive in infancy (HP:0001531)2.06967179
97Bradykinesia (HP:0002067)2.05875017
98Abnormality of binocular vision (HP:0011514)2.05600573
99Diplopia (HP:0000651)2.05600573
100Hand muscle atrophy (HP:0009130)2.05060322
101Lower limb amyotrophy (HP:0007210)2.04291605
102Abnormality of the corticospinal tract (HP:0002492)2.03731231
103Hypoventilation (HP:0002791)2.03417503
104Hemorrhage of the eye (HP:0011885)2.03354822
105Atelectasis (HP:0100750)2.03023404
106Akinesia (HP:0002304)2.02858079
107Visceral angiomatosis (HP:0100761)2.02018050
108Urinary glycosaminoglycan excretion (HP:0003541)2.01254161
109Mucopolysacchariduria (HP:0008155)2.01254161
110Impaired pain sensation (HP:0007328)2.00835531
111Abnormality of pain sensation (HP:0010832)2.00835531
112Myopathic facies (HP:0002058)1.98995200
113Mitral regurgitation (HP:0001653)1.98361182
114Hyperventilation (HP:0002883)1.97990083
115Mildly elevated creatine phosphokinase (HP:0008180)1.97683805
116Exercise-induced myalgia (HP:0003738)1.97539634
117Fetal akinesia sequence (HP:0001989)1.97231419
118Oligomenorrhea (HP:0000876)1.97071546
119Epileptiform EEG discharges (HP:0011182)1.96851365
120Biconcave vertebral bodies (HP:0004586)1.96717985
121Generalized hypotonia (HP:0001290)1.96155761
122Protrusio acetabuli (HP:0003179)1.96149151
123Lower limb asymmetry (HP:0100559)1.93756615
124Resting tremor (HP:0002322)1.93345108
125Growth hormone excess (HP:0000845)1.93148584
126Hammertoe (HP:0001765)1.92664977
127Easy fatigability (HP:0003388)1.92492364
128Abnormality of ocular smooth pursuit (HP:0000617)1.91215527
129Psychosis (HP:0000709)1.89262454
130Increased IgE level (HP:0003212)1.89230335
131Long palpebral fissure (HP:0000637)1.88735555
132Gait ataxia (HP:0002066)1.87429523
133Broad metatarsal (HP:0001783)1.87110312
134Neuronal loss in central nervous system (HP:0002529)1.87057883
135Incomplete penetrance (HP:0003829)1.86679027
136Papilledema (HP:0001085)1.86251272
137Impaired vibratory sensation (HP:0002495)1.86226914
138Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86177361
139Abnormality of polysaccharide metabolism (HP:0011012)1.86177361
140Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86177361
141EEG with generalized epileptiform discharges (HP:0011198)1.85943865
142Spinal cord compression (HP:0002176)1.85648688
143Achilles tendon contracture (HP:0001771)1.85455008
144Spinal canal stenosis (HP:0003416)1.84980106
145Asymmetry of the thorax (HP:0001555)1.83881007
146Menstrual irregularities (HP:0000858)1.83133656
147Neoplasm of the peripheral nervous system (HP:0100007)1.80771779
148Slow progression (HP:0003677)1.80752744
149Hemangiomatosis (HP:0007461)1.80512961
150Bradycardia (HP:0001662)1.80478099
151Clonus (HP:0002169)1.80403147
152Reticulocytosis (HP:0001923)1.79475108
153Bell-shaped thorax (HP:0001591)1.76231838
154Precocious puberty (HP:0000826)1.74567001
155Distal sensory impairment (HP:0002936)1.74374365
156Slow saccadic eye movements (HP:0000514)1.74256985
157Centrally nucleated skeletal muscle fibers (HP:0003687)1.73315503
158Bowel incontinence (HP:0002607)1.72481633
159Cellulitis (HP:0100658)1.71456210
160Onion bulb formation (HP:0003383)1.71430483
161Sleep apnea (HP:0010535)1.71406229
162Colitis (HP:0002583)1.69525793
163Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69435120
164Aneurysm (HP:0002617)1.69214684
165Advanced eruption of teeth (HP:0006288)1.68936663
166Right ventricular cardiomyopathy (HP:0011663)1.68689893
167Joint stiffness (HP:0001387)1.67512084
168Difficulty climbing stairs (HP:0003551)1.67499014
169Abnormality of the nasal mucosa (HP:0000433)1.66496357
170Axonal loss (HP:0003447)1.65996284
171Fragile skin (HP:0001030)1.65143744
172Neoplasm of the heart (HP:0100544)1.65009676
173Nasal polyposis (HP:0100582)1.64465808
174Foot dorsiflexor weakness (HP:0009027)1.64332505
175Flattened epiphyses (HP:0003071)1.63043789
176Interstitial pulmonary disease (HP:0006530)1.62443737
177Abnormality of nail color (HP:0100643)1.62076380
178Broad distal phalanx of finger (HP:0009836)1.61832751
179Emphysema (HP:0002097)1.60158360
180Vertebral compression fractures (HP:0002953)1.60001526
181Abnormality of the salivary glands (HP:0010286)1.59681703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.46042506
2EPHA43.94585837
3MAP3K93.53835112
4SIK13.49515814
5DAPK22.83990885
6MINK12.70746179
7SMG12.64623023
8ERN12.58718213
9CASK2.52608570
10EEF2K2.49022185
11MAP3K42.46036391
12KSR22.36910128
13EPHA22.24261296
14ICK2.21358035
15PKN22.15503535
16PRPF4B2.15104664
17PAK62.12527779
18ARAF2.02811788
19PRKD32.00692594
20CAMKK11.92097774
21NTRK11.84606795
22MAP2K71.76856724
23LMTK21.76037983
24MARK11.70460485
25NTRK21.67222989
26PHKG21.63927153
27PHKG11.63927153
28DAPK11.61808325
29MAP2K41.58930646
30CDK51.58924898
31MAP3K121.53487958
32GRK51.50724247
33CAMKK21.42913339
34KSR11.38860158
35MAP3K21.37842298
36FGFR41.36771836
37TESK11.35031769
38RIPK41.33870981
39UHMK11.27886528
40TNIK1.27601425
41MAP3K111.27434657
42MST1R1.26716273
43STK381.26681036
44MAPK131.17671713
45PTK61.17131417
46CDK121.14879611
47PRKCH1.09771390
48CDK191.08388152
49PDGFRA1.05494394
50IRAK31.05345140
51PRKCG1.03238716
52CAMK11.03204864
53PLK21.02907419
54RIPK11.02178763
55TNK21.01418822
56MAPK151.01205739
57PTK2B1.00640665
58RET1.00126460
59MAP2K30.99856121
60TRIB30.98292621
61TYRO30.98270786
62MAP3K130.93943793
63MAP2K60.93601220
64NME20.93013671
65SGK2230.92580509
66SGK4940.92580509
67MTOR0.92468196
68NEK60.90580652
69MAPK120.90506475
70FES0.89814226
71BMX0.87585279
72MAP3K100.87070663
73CAMK2B0.86627113
74CAMK2A0.86531179
75PAK30.86015935
76SIK20.85922877
77TAOK10.85638307
78MAP3K60.85559394
79CAMK1G0.85159040
80CDK180.84943536
81CDK140.83818507
82GRK60.82932783
83CDK150.81286154
84MAP2K20.80657639
85PINK10.80269796
86PTK20.79993401
87HIPK20.78353763
88STK110.76775379
89RAF10.74250941
90FER0.73310001
91EPHB10.72987056
92RPS6KL10.72499422
93RPS6KC10.72499422
94WNK10.72102727
95TAOK20.71118730
96OXSR10.70822451
97CDK11A0.70160100
98TTN0.69781432
99MAP2K10.69071949
100PDPK10.68484450
101CDC42BPA0.68446018
102DAPK30.68042418
103MARK20.67261034
104MAP3K30.66995116
105PDK10.65362052
106MAP4K10.65241694
107CAMK2G0.63157724
108MAP3K10.60831835
109CSNK1G20.60821942
110TBK10.60821495
111SIK30.60105047
112CAMK2D0.59170926
113BRAF0.58872339
114ROCK20.55858801
115RPS6KB20.55340447
116SCYL20.54384226
117TESK20.54004653
118SGK30.54001341
119PAK40.53675192
120STK390.53343063
121PNCK0.53126031
122MAP3K70.53036919
123IRAK20.52836396
124SGK20.52560742
125RPS6KA60.52113887
126ZAP700.51207231
127LRRK20.50689629
128SGK10.49941277
129LATS20.49706442
130PRKD20.48854458
131MET0.47517717
132MAPK110.47101546
133DYRK1A0.46907221
134PRKG20.46086317
135ALK0.45926914
136DDR20.45730618
137FYN0.45362893
138DYRK1B0.44980514
139PRKD10.44233076
140MAPKAPK30.44051830
141RPS6KA30.43750029
142ERBB20.43703267
143RPS6KA20.42510872
144MUSK0.41799153
145CAMK1D0.41689214
146PRKCZ0.41319164
147CAMK40.40414259
148MAPK80.40008705
149LIMK10.38764649
150PRKCE0.38635915
151WNK40.38341928
152NME10.34409886
153MAPK100.34133188

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.26453086
2Synaptic vesicle cycle_Homo sapiens_hsa047213.25698302
3Nicotine addiction_Homo sapiens_hsa050333.05072167
4Circadian entrainment_Homo sapiens_hsa047132.63015549
5GABAergic synapse_Homo sapiens_hsa047272.46915700
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43159803
7Long-term potentiation_Homo sapiens_hsa047202.41767692
8Glutamatergic synapse_Homo sapiens_hsa047242.39848724
9Morphine addiction_Homo sapiens_hsa050322.35891395
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29086110
11Amphetamine addiction_Homo sapiens_hsa050312.25784021
12Dopaminergic synapse_Homo sapiens_hsa047282.12586925
13Salivary secretion_Homo sapiens_hsa049702.12003845
14Other glycan degradation_Homo sapiens_hsa005111.96985957
15Insulin secretion_Homo sapiens_hsa049111.94124338
16Notch signaling pathway_Homo sapiens_hsa043301.93663819
17Gastric acid secretion_Homo sapiens_hsa049711.89303750
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.84965753
19Cholinergic synapse_Homo sapiens_hsa047251.82060906
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81075727
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77738611
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76794563
23Taste transduction_Homo sapiens_hsa047421.74052153
24Renin secretion_Homo sapiens_hsa049241.67108141
25Oxytocin signaling pathway_Homo sapiens_hsa049211.59515330
26Cocaine addiction_Homo sapiens_hsa050301.58291925
27Calcium signaling pathway_Homo sapiens_hsa040201.55290347
28Long-term depression_Homo sapiens_hsa047301.50741607
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47665660
30Acute myeloid leukemia_Homo sapiens_hsa052211.45921111
31Serotonergic synapse_Homo sapiens_hsa047261.43546161
32GnRH signaling pathway_Homo sapiens_hsa049121.41065399
33Chronic myeloid leukemia_Homo sapiens_hsa052201.38374548
34Collecting duct acid secretion_Homo sapiens_hsa049661.38357356
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35456900
36Cardiac muscle contraction_Homo sapiens_hsa042601.30753524
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30294729
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.29504095
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29163442
40Gap junction_Homo sapiens_hsa045401.26935960
41cAMP signaling pathway_Homo sapiens_hsa040241.26864815
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20426688
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17825473
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16688786
45Fructose and mannose metabolism_Homo sapiens_hsa000511.14227581
46B cell receptor signaling pathway_Homo sapiens_hsa046621.11835230
47Type II diabetes mellitus_Homo sapiens_hsa049301.11401081
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10913771
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10537389
50Estrogen signaling pathway_Homo sapiens_hsa049151.04892292
51Glioma_Homo sapiens_hsa052141.03237465
52Melanogenesis_Homo sapiens_hsa049160.99989835
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.99892488
54Sulfur relay system_Homo sapiens_hsa041220.99456037
55Renal cell carcinoma_Homo sapiens_hsa052110.97049391
56Vibrio cholerae infection_Homo sapiens_hsa051100.95549537
57Bladder cancer_Homo sapiens_hsa052190.94132101
58Axon guidance_Homo sapiens_hsa043600.91494965
59Dilated cardiomyopathy_Homo sapiens_hsa054140.89572389
60Pancreatic secretion_Homo sapiens_hsa049720.89301383
61Pancreatic cancer_Homo sapiens_hsa052120.87801568
62ErbB signaling pathway_Homo sapiens_hsa040120.87642222
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.87008997
64Thyroid cancer_Homo sapiens_hsa052160.86127064
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86091024
66Prolactin signaling pathway_Homo sapiens_hsa049170.85340260
67Hepatitis C_Homo sapiens_hsa051600.84642708
68Nitrogen metabolism_Homo sapiens_hsa009100.83651169
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82908863
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80963130
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.80692684
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80261384
73Thyroid hormone synthesis_Homo sapiens_hsa049180.80085636
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78633824
75Oocyte meiosis_Homo sapiens_hsa041140.77962603
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77307257
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75613993
78Insulin resistance_Homo sapiens_hsa049310.71623437
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71410430
80Focal adhesion_Homo sapiens_hsa045100.70622537
81Dorso-ventral axis formation_Homo sapiens_hsa043200.70239755
82Alzheimers disease_Homo sapiens_hsa050100.69747877
83Glucagon signaling pathway_Homo sapiens_hsa049220.68006953
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.67905328
85VEGF signaling pathway_Homo sapiens_hsa043700.64829903
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64246602
87Fatty acid biosynthesis_Homo sapiens_hsa000610.64242732
88Proteoglycans in cancer_Homo sapiens_hsa052050.62388187
89Insulin signaling pathway_Homo sapiens_hsa049100.62253746
90Amoebiasis_Homo sapiens_hsa051460.62078950
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60551116
92Choline metabolism in cancer_Homo sapiens_hsa052310.60340188
93Phototransduction_Homo sapiens_hsa047440.59986194
94Tight junction_Homo sapiens_hsa045300.59178934
95Vitamin B6 metabolism_Homo sapiens_hsa007500.58957854
96Arginine biosynthesis_Homo sapiens_hsa002200.58013523
97Lysosome_Homo sapiens_hsa041420.57472451
98HIF-1 signaling pathway_Homo sapiens_hsa040660.56788153
99Parkinsons disease_Homo sapiens_hsa050120.56417380
100Histidine metabolism_Homo sapiens_hsa003400.55974726
101MAPK signaling pathway_Homo sapiens_hsa040100.55480003
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55198424
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53164948
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53054662
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52521764
106Rap1 signaling pathway_Homo sapiens_hsa040150.52157290
107* Endocytosis_Homo sapiens_hsa041440.52015113
108Ras signaling pathway_Homo sapiens_hsa040140.51196033
109Bile secretion_Homo sapiens_hsa049760.51048909
110Inositol phosphate metabolism_Homo sapiens_hsa005620.50709343
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50539208
112Oxidative phosphorylation_Homo sapiens_hsa001900.49478379
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.47211117
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46856231
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46592238
116Alcoholism_Homo sapiens_hsa050340.44032817
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43394227
118Endometrial cancer_Homo sapiens_hsa052130.42990036
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42483784
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42460459
121Non-small cell lung cancer_Homo sapiens_hsa052230.37970015
122Prion diseases_Homo sapiens_hsa050200.37923997
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36417022
124Glycerolipid metabolism_Homo sapiens_hsa005610.35034089
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.34158112
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.32972916
127mTOR signaling pathway_Homo sapiens_hsa041500.32847291
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.30329255
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30119393
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29524506
131AMPK signaling pathway_Homo sapiens_hsa041520.28279242
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27977543
133Circadian rhythm_Homo sapiens_hsa047100.26856806

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