SH2D5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.95411808
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.34339590
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.16510264
4synaptic vesicle maturation (GO:0016188)6.14979954
5locomotory exploration behavior (GO:0035641)5.79807880
6regulation of synapse structural plasticity (GO:0051823)5.53293518
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.49956903
8synaptic vesicle exocytosis (GO:0016079)5.49750504
9vocalization behavior (GO:0071625)5.46678010
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.37074622
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.27201471
12regulation of glutamate receptor signaling pathway (GO:1900449)5.24317675
13regulation of long-term neuronal synaptic plasticity (GO:0048169)5.10576975
14sodium ion export (GO:0071436)4.96751734
15regulation of synaptic vesicle exocytosis (GO:2000300)4.95756114
16prepulse inhibition (GO:0060134)4.91821382
17regulation of neuronal synaptic plasticity (GO:0048168)4.85634275
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.84790330
19synaptic transmission, dopaminergic (GO:0001963)4.83899666
20cell-substrate junction assembly (GO:0007044)4.80035188
21protein localization to synapse (GO:0035418)4.69895603
22neurotransmitter-gated ion channel clustering (GO:0072578)4.68266604
23neuronal action potential propagation (GO:0019227)4.65638597
24glutamate secretion (GO:0014047)4.62373706
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.59906769
26neurotransmitter secretion (GO:0007269)4.55783208
27positive regulation of synaptic transmission, GABAergic (GO:0032230)4.53542169
28positive regulation of neurotransmitter transport (GO:0051590)4.49624487
29G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.49567469
30regulation of synaptic vesicle transport (GO:1902803)4.48473708
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.45147356
32neuron-neuron synaptic transmission (GO:0007270)4.44550844
33positive regulation of membrane potential (GO:0045838)4.42860392
34synaptic transmission, glutamatergic (GO:0035249)4.39994088
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.29784682
36exploration behavior (GO:0035640)4.27587135
37regulation of excitatory postsynaptic membrane potential (GO:0060079)4.25851426
38long-term memory (GO:0007616)4.25267893
39cytoskeletal anchoring at plasma membrane (GO:0007016)4.24528691
40striatum development (GO:0021756)4.23277175
41positive regulation of neurotransmitter secretion (GO:0001956)4.19552415
42positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.18175384
43auditory behavior (GO:0031223)4.17449499
44glutamate receptor signaling pathway (GO:0007215)4.16119227
45regulation of dendritic spine morphogenesis (GO:0061001)4.11189822
46desmosome organization (GO:0002934)4.06457836
47adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.04702462
48negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.00853285
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.99556494
50regulation of postsynaptic membrane potential (GO:0060078)3.97235812
51response to amphetamine (GO:0001975)3.97119165
52neuron cell-cell adhesion (GO:0007158)3.91871200
53dendritic spine morphogenesis (GO:0060997)3.90991592
54dopamine receptor signaling pathway (GO:0007212)3.88453885
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.88402744
56amino acid import (GO:0043090)3.87588962
57regulation of synaptic plasticity (GO:0048167)3.87411281
58adenosine receptor signaling pathway (GO:0001973)3.83878753
59transmission of nerve impulse (GO:0019226)3.75524808
60behavioral response to cocaine (GO:0048148)3.75298576
61regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.74986695
62regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.74986695
63response to histamine (GO:0034776)3.71900113
64response to auditory stimulus (GO:0010996)3.71278434
65long-term synaptic potentiation (GO:0060291)3.70911786
66neuromuscular process controlling balance (GO:0050885)3.70653429
67regulation of glutamate secretion (GO:0014048)3.68289240
68regulation of female receptivity (GO:0045924)3.68084466
69mechanosensory behavior (GO:0007638)3.65815714
70layer formation in cerebral cortex (GO:0021819)3.65775640
71behavioral defense response (GO:0002209)3.63440351
72behavioral fear response (GO:0001662)3.63440351
73positive regulation of synapse maturation (GO:0090129)3.60185565
74membrane hyperpolarization (GO:0060081)3.56436741
75activation of protein kinase A activity (GO:0034199)3.56054931
76neurotransmitter transport (GO:0006836)3.55642790
77gamma-aminobutyric acid transport (GO:0015812)3.54666177
78cellular potassium ion homeostasis (GO:0030007)3.52585016
79negative regulation of cytosolic calcium ion concentration (GO:0051481)3.51732910
80neuronal ion channel clustering (GO:0045161)3.49533295
81regulation of neurotransmitter levels (GO:0001505)3.47611417
82protein localization to endosome (GO:0036010)3.46937462
83regulation of neurotransmitter uptake (GO:0051580)3.46304724
84visual learning (GO:0008542)3.42554605
85regulation of neurotransmitter transport (GO:0051588)3.41756862
86regulation of neurotransmitter secretion (GO:0046928)3.41343341
87cAMP catabolic process (GO:0006198)3.41210960
88positive regulation of synaptic transmission (GO:0050806)3.39691000
89learning (GO:0007612)3.36729243
90membrane depolarization (GO:0051899)3.36546046
91regulation of protein kinase A signaling (GO:0010738)3.36135911
92regulation of voltage-gated calcium channel activity (GO:1901385)3.34572457
93regulation of dendritic spine development (GO:0060998)3.32825629
94positive regulation of dendritic spine morphogenesis (GO:0061003)3.31618874
95keratinocyte proliferation (GO:0043616)3.30262817
96focal adhesion assembly (GO:0048041)3.27728626
97cell-substrate adherens junction assembly (GO:0007045)3.27728626
98fear response (GO:0042596)3.26969099
99regulation of synaptic transmission, GABAergic (GO:0032228)3.26673482
100female mating behavior (GO:0060180)3.26526459
101positive regulation of dendritic spine development (GO:0060999)3.26320436
102regulation of vesicle fusion (GO:0031338)3.25218031
103visual behavior (GO:0007632)3.25004711
104phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.24973519
105negative regulation of dendrite morphogenesis (GO:0050774)3.24068193
106mating behavior (GO:0007617)3.23673311
107cell adhesion mediated by integrin (GO:0033627)3.22849994
108negative regulation of dendrite development (GO:2000171)3.21531551
109gamma-aminobutyric acid signaling pathway (GO:0007214)3.21308091
110adherens junction assembly (GO:0034333)3.20849488
111glycine transport (GO:0015816)3.19459114
112neuromuscular process controlling posture (GO:0050884)3.14386481
113membrane depolarization during action potential (GO:0086010)3.11376490
114L-amino acid import (GO:0043092)3.07129158
115negative regulation of amino acid transport (GO:0051956)3.06648257
116cerebellar granule cell differentiation (GO:0021707)3.05905455
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03307728
118regulation of early endosome to late endosome transport (GO:2000641)2.96878623
119negative regulation of keratinocyte proliferation (GO:0010839)2.95820311
120cell communication by electrical coupling (GO:0010644)2.94659529
121synaptic vesicle endocytosis (GO:0048488)2.92081627
122protein complex localization (GO:0031503)2.82787990
123negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79768047
124keratinization (GO:0031424)2.79122403
125activation of Rac GTPase activity (GO:0032863)2.75966282
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.74412390
127cellular protein complex localization (GO:0034629)2.71945480
128cell communication involved in cardiac conduction (GO:0086065)2.71059227
129skin morphogenesis (GO:0043589)2.70092691
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69878225
131postsynaptic membrane organization (GO:0001941)2.69517063
132potassium ion homeostasis (GO:0055075)2.68152785
133dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.61704882
134establishment of skin barrier (GO:0061436)2.57587611
135regulation of water loss via skin (GO:0033561)2.57503849
136endodermal cell differentiation (GO:0035987)2.56044210
137mesodermal cell differentiation (GO:0048333)2.55751516
138regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.54825871
139maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54711304
140protein retention in ER lumen (GO:0006621)2.54338821
141neuron projection extension (GO:1990138)2.50650683
142response to gravity (GO:0009629)2.49918440
143dicarboxylic acid transport (GO:0006835)2.49266125
144regulation of synapse maturation (GO:0090128)2.48840610
145vesicle docking involved in exocytosis (GO:0006904)2.48589281
146vesicle docking (GO:0048278)2.47734012
147positive regulation of vesicle fusion (GO:0031340)2.46953113
148dendritic spine organization (GO:0097061)2.45737951
149cell junction assembly (GO:0034329)2.45003906
150regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43571362
151positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.42464075
152regulation of ARF protein signal transduction (GO:0032012)2.41426910
153axon extension (GO:0048675)2.38593719
154regulation of hair follicle development (GO:0051797)2.37974327
155cerebellar Purkinje cell layer development (GO:0021680)2.37563806
156heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.36556516
157membrane tubulation (GO:0097320)2.34383806
158polarized epithelial cell differentiation (GO:0030859)2.34360437
159protein targeting to plasma membrane (GO:0072661)2.32125144
160cell junction organization (GO:0034330)2.31509464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.43350555
2EZH2_22144423_ChIP-Seq_EOC_Human6.63180162
3* RARB_27405468_Chip-Seq_BRAIN_Mouse4.31166444
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.44185871
5GBX2_23144817_ChIP-Seq_PC3_Human3.41834032
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.33081010
7REST_21632747_ChIP-Seq_MESCs_Mouse3.32782928
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.28211955
9JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20254277
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11210808
11IKZF1_21737484_ChIP-ChIP_HCT116_Human3.09490060
12DROSHA_22980978_ChIP-Seq_HELA_Human3.04246288
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.84934930
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79921664
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69644703
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69644703
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.68708287
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65245732
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.64299761
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.46982865
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46789231
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.45343560
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43625064
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.43259612
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.35762447
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35045952
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34113598
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29814388
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.26746177
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.17543410
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.16506905
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.16366734
33TAF15_26573619_Chip-Seq_HEK293_Human1.95048208
34* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.94797764
35AR_21572438_ChIP-Seq_LNCaP_Human1.91266347
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88602209
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.79465777
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.78540385
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75933864
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69944699
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.68856809
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67062875
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66306149
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64870873
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64840839
46ZNF263_19887448_ChIP-Seq_K562_Human1.64442148
47* LXR_22292898_ChIP-Seq_THP-1_Human1.63972586
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62427802
49RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.56034701
50* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55073779
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54980642
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50923654
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50845394
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50845394
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49905211
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47402354
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42428589
58SMAD4_21799915_ChIP-Seq_A2780_Human1.42045448
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.42012894
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41356104
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.40380286
62* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.39716863
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39181627
64RACK7_27058665_Chip-Seq_MCF-7_Human1.38383680
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37818356
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35955444
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.35565573
68ATF3_27146783_Chip-Seq_COLON_Human1.35462562
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.35319248
70EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35314772
71TP53_22127205_ChIP-Seq_IMR90_Human1.34500088
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33927070
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29880632
74* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25997594
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25771390
76* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25727970
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.25567978
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.24048641
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23473002
80* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23117090
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.22545363
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.20935874
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20688543
84KDM2B_26808549_Chip-Seq_K562_Human1.20678501
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19284957
86TP53_23651856_ChIP-Seq_MEFs_Mouse1.17171268
87CLOCK_20551151_ChIP-Seq_293T_Human1.15124218
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12400865
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11741645
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10510247
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09601797
92TET1_21451524_ChIP-Seq_MESCs_Mouse1.09096092
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.08635202
94AR_19668381_ChIP-Seq_PC3_Human1.08029866
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07215274
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06686094
97P300_19829295_ChIP-Seq_ESCs_Human1.05897398
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05580384
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05543321
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05357932
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05214606
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04727737
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04483339
104* TP63_22573176_ChIP-Seq_HFKS_Human1.03765994
105ZNF274_21170338_ChIP-Seq_K562_Hela1.02510234
106CTCF_27219007_Chip-Seq_Bcells_Human1.01854931
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01812679
108GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01317870
109AR_25329375_ChIP-Seq_VCAP_Human1.00752895
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00203515
111STAT3_23295773_ChIP-Seq_U87_Human0.99955351
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99849486
113CREB1_26743006_Chip-Seq_LNCaP_Human0.99417297
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99376347
115TCF4_23295773_ChIP-Seq_U87_Human0.98206779
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96803709
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96313947
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96215233
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95453645
120AR_21909140_ChIP-Seq_LNCAP_Human0.94914318
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94638903
122YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94195073
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93234860
124TET1_21490601_ChIP-Seq_MESCs_Mouse0.92749539
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92191538
126* SA1_27219007_Chip-Seq_ERYTHROID_Human0.92112132
127KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91385308
128SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91104908
129ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91010563
130SMAD_19615063_ChIP-ChIP_OVARY_Human0.89701426
131P68_20966046_ChIP-Seq_HELA_Human0.89701163
132RING1B_27294783_Chip-Seq_NPCs_Mouse0.88657756
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.88445025
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87857116
135PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87345010
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.86722997
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86715744
138IGF1R_20145208_ChIP-Seq_DFB_Human0.85814687
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85698658
140ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85535510
141SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85325967
142ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85025597
143DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84351221
144RNF2_27304074_Chip-Seq_NSC_Mouse0.81625391
145RUNX2_22187159_ChIP-Seq_PCA_Human0.81578627
146DPY_21335234_ChIP-Seq_ESCs_Mouse0.78389984
147SPI1_23127762_ChIP-Seq_K562_Human0.78382260
148JUN_21703547_ChIP-Seq_K562_Human0.78253726
149OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78171905
150TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76118268
151KLF4_19829295_ChIP-Seq_ESCs_Human0.75278774
152SMC4_20622854_ChIP-Seq_HELA_Human0.74988863
153SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74818014
154SMAD3_21741376_ChIP-Seq_HESCs_Human0.74419960
155TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.73023464
156OCT4_19829295_ChIP-Seq_ESCs_Human0.71584448
157FLI1_21867929_ChIP-Seq_TH2_Mouse0.71518668
158SMAD4_21741376_ChIP-Seq_ESCs_Human0.69650342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.72205594
2MP0002822_catalepsy6.10273527
3MP0000579_abnormal_nail_morphology5.03625762
4MP0003880_abnormal_central_pattern4.84414749
5MP0003635_abnormal_synaptic_transmissio4.30127375
6MP0009745_abnormal_behavioral_response3.75949723
7MP0002063_abnormal_learning/memory/cond3.50243403
8MP0002064_seizures3.25106208
9MP0004270_analgesia3.13324750
10MP0003705_abnormal_hypodermis_morpholog3.13066139
11MP0003941_abnormal_skin_development3.07666815
12MP0009046_muscle_twitch3.02784302
13MP0001968_abnormal_touch/_nociception2.99380557
14MP0002572_abnormal_emotion/affect_behav2.89484979
15MP0005423_abnormal_somatic_nervous2.77934029
16MP0002272_abnormal_nervous_system2.73557753
17MP0001486_abnormal_startle_reflex2.68599946
18MP0001529_abnormal_vocalization2.59049214
19MP0005623_abnormal_meninges_morphology2.51420543
20MP0003566_abnormal_cell_adhesion2.49892586
21MP0000762_abnormal_tongue_morphology2.44030654
22MP0001501_abnormal_sleep_pattern2.39088393
23MP0002736_abnormal_nociception_after2.29223966
24MP0002734_abnormal_mechanical_nocicepti2.26143903
25MP0002909_abnormal_adrenal_gland2.17102268
26MP0002796_impaired_skin_barrier2.13734529
27MP0004272_abnormal_basement_membrane2.12555118
28MP0001849_ear_inflammation2.04089492
29MP0005646_abnormal_pituitary_gland1.99200678
30MP0001970_abnormal_pain_threshold1.94759675
31MP0008569_lethality_at_weaning1.91606464
32MP0002735_abnormal_chemical_nociception1.88379803
33MP0005386_behavior/neurological_phenoty1.85329792
34MP0004924_abnormal_behavior1.85329792
35MP0001299_abnormal_eye_distance/1.83708129
36MP0002733_abnormal_thermal_nociception1.82838134
37MP0000467_abnormal_esophagus_morphology1.81878298
38MP0003879_abnormal_hair_cell1.79538101
39MP0001440_abnormal_grooming_behavior1.76630355
40MP0000537_abnormal_urethra_morphology1.75115069
41MP0005409_darkened_coat_color1.74675820
42MP0004811_abnormal_neuron_physiology1.72997861
43MP0002067_abnormal_sensory_capabilities1.70101153
44MP0002557_abnormal_social/conspecific_i1.68545117
45MP0000566_synostosis1.67138231
46MP0002060_abnormal_skin_morphology1.66571677
47MP0001188_hyperpigmentation1.65699819
48MP0009780_abnormal_chondrocyte_physiolo1.58487579
49MP0002234_abnormal_pharynx_morphology1.57935915
50MP0001984_abnormal_olfaction1.56679430
51MP0005501_abnormal_skin_physiology1.48997753
52MP0009053_abnormal_anal_canal1.48773457
53MP0001905_abnormal_dopamine_level1.46236454
54MP0005257_abnormal_intraocular_pressure1.45919384
55MP0003453_abnormal_keratinocyte_physiol1.43439574
56MP0005275_abnormal_skin_tensile1.38948862
57MP0003075_altered_response_to1.38701038
58MP0003329_amyloid_beta_deposits1.38429345
59MP0001348_abnormal_lacrimal_gland1.38059702
60MP0002089_abnormal_postnatal_growth/wei1.35614774
61MP0005023_abnormal_wound_healing1.33984970
62MP0002184_abnormal_innervation1.33423164
63MP0003950_abnormal_plasma_membrane1.32837716
64MP0002066_abnormal_motor_capabilities/c1.32256575
65MP0010771_integument_phenotype1.31473693
66MP0003633_abnormal_nervous_system1.30805921
67MP0008438_abnormal_cutaneous_collagen1.29989654
68MP0008874_decreased_physiological_sensi1.29442549
69MP0005645_abnormal_hypothalamus_physiol1.28359685
70MP0008872_abnormal_physiological_respon1.28335382
71MP0003787_abnormal_imprinting1.26601422
72MP0000955_abnormal_spinal_cord1.25152562
73MP0001502_abnormal_circadian_rhythm1.24153197
74MP0004142_abnormal_muscle_tone1.23906928
75MP0008260_abnormal_autophagy1.23735268
76MP0001216_abnormal_epidermal_layer1.21694021
77MP0000678_abnormal_parathyroid_gland1.17191709
78MP0002882_abnormal_neuron_morphology1.16160095
79MP0008961_abnormal_basal_metabolism1.15860463
80MP0006276_abnormal_autonomic_nervous1.13704265
81MP0004885_abnormal_endolymph1.10888956
82MP0003123_paternal_imprinting1.10175815
83MP0000013_abnormal_adipose_tissue1.07896077
84MP0001346_abnormal_lacrimal_gland1.06459803
85MP0010030_abnormal_orbit_morphology1.02913905
86MP0004858_abnormal_nervous_system1.02853138
87MP0003183_abnormal_peptide_metabolism1.01918571
88MP0003631_nervous_system_phenotype1.00222355
89MP0005535_abnormal_body_temperature0.93601821
90MP0002069_abnormal_eating/drinking_beha0.92831701
91MP0010678_abnormal_skin_adnexa0.91961923
92MP0003091_abnormal_cell_migration0.88573025
93MP0010352_gastrointestinal_tract_polyps0.88421181
94MP0000534_abnormal_ureter_morphology0.88181602
95MP0010368_abnormal_lymphatic_system0.87713544
96MP0001177_atelectasis0.87172349
97MP0000778_abnormal_nervous_system0.85974211
98MP0003172_abnormal_lysosome_physiology0.84308186
99MP0002098_abnormal_vibrissa_morphology0.84248360
100MP0002229_neurodegeneration0.84146143
101MP0002152_abnormal_brain_morphology0.83497080
102MP0000003_abnormal_adipose_tissue0.83257466
103MP0003385_abnormal_body_wall0.82014066
104MP0004085_abnormal_heartbeat0.81711372
105MP0003755_abnormal_palate_morphology0.79940061
106MP0009672_abnormal_birth_weight0.79327725
107MP0005551_abnormal_eye_electrophysiolog0.78567393
108MP0000751_myopathy0.75579300
109MP0001340_abnormal_eyelid_morphology0.74815680
110MP0005499_abnormal_olfactory_system0.74201046
111MP0005394_taste/olfaction_phenotype0.74201046
112MP0003861_abnormal_nervous_system0.73884159
113MP0001958_emphysema0.73506436
114MP0005167_abnormal_blood-brain_barrier0.73034379
115MP0002638_abnormal_pupillary_reflex0.72395200
116MP0002697_abnormal_eye_size0.71624287
117MP0003315_abnormal_perineum_morphology0.71485506
118MP0003690_abnormal_glial_cell0.71141299
119MP0010386_abnormal_urinary_bladder0.70625627
120MP0001664_abnormal_digestion0.69583191
121MP0002090_abnormal_vision0.68680691
122MP0000428_abnormal_craniofacial_morphol0.67657875
123MP0000733_abnormal_muscle_development0.67477009
124MP0003122_maternal_imprinting0.67152925
125MP0003303_peritoneal_inflammation0.66768623
126MP0002877_abnormal_melanocyte_morpholog0.66736067
127MP0000377_abnormal_hair_follicle0.66691254
128MP0000569_abnormal_digit_pigmentation0.66075487
129MP0000631_abnormal_neuroendocrine_gland0.65773551
130MP0000920_abnormal_myelination0.64239964
131MP0002081_perinatal_lethality0.64140499
132MP0008877_abnormal_DNA_methylation0.63224464
133MP0002177_abnormal_outer_ear0.62024619
134MP0004233_abnormal_muscle_weight0.60450993
135MP0002896_abnormal_bone_mineralization0.60213706
136MP0001963_abnormal_hearing_physiology0.60150901
137MP0000462_abnormal_digestive_system0.59054371
138MP0000604_amyloidosis0.56904553
139MP0001485_abnormal_pinna_reflex0.56340629
140MP0010234_abnormal_vibrissa_follicle0.53969955
141MP0005166_decreased_susceptibility_to0.53009141
142MP0004742_abnormal_vestibular_system0.50746308
143MP0003956_abnormal_body_size0.50532201
144MP0003634_abnormal_glial_cell0.48333493
145MP0003866_abnormal_defecation0.48055280
146MP0005174_abnormal_tail_pigmentation0.47779408
147MP0002396_abnormal_hematopoietic_system0.47522725
148MP0003632_abnormal_nervous_system0.45502409
149MP0001943_abnormal_respiration0.45001302
150MP0005310_abnormal_salivary_gland0.44763689
151MP0002876_abnormal_thyroid_physiology0.43953987
152MP0003283_abnormal_digestive_organ0.43438744
153MP0010769_abnormal_survival0.42217918
154MP0001986_abnormal_taste_sensitivity0.42088425
155MP0002752_abnormal_somatic_nervous0.42035428
156MP0001765_abnormal_ion_homeostasis0.40854648

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.30239212
2Myokymia (HP:0002411)8.25337032
3Focal seizures (HP:0007359)5.89833249
4Milia (HP:0001056)5.53921319
5Visual hallucinations (HP:0002367)5.40398503
6Atrophic scars (HP:0001075)5.18437013
7Fragile nails (HP:0001808)5.12887295
8Abnormality of nail color (HP:0100643)4.92805281
9Onycholysis (HP:0001806)4.72618795
10Epileptic encephalopathy (HP:0200134)4.68440067
11Papilledema (HP:0001085)4.60442419
12Febrile seizures (HP:0002373)4.39205480
13Atonic seizures (HP:0010819)4.20729195
14Plantar hyperkeratosis (HP:0007556)4.16391888
15Poor eye contact (HP:0000817)4.12806083
16Absence seizures (HP:0002121)4.10975806
17Thick nail (HP:0001805)4.08588636
18Generalized tonic-clonic seizures (HP:0002069)3.80517622
19Dialeptic seizures (HP:0011146)3.78983806
20Broad-based gait (HP:0002136)3.78921542
21Depression (HP:0000716)3.72704992
22Annular pancreas (HP:0001734)3.72010253
23Impaired vibration sensation in the lower limbs (HP:0002166)3.56510803
24Anxiety (HP:0000739)3.54151120
25Ankle clonus (HP:0011448)3.54038762
26Gaze-evoked nystagmus (HP:0000640)3.53367607
27Neurofibrillary tangles (HP:0002185)3.52047189
28Abnormal social behavior (HP:0012433)3.51199398
29Impaired social interactions (HP:0000735)3.51199398
30Torticollis (HP:0000473)3.48340059
31Cerebral inclusion bodies (HP:0100314)3.39025501
32Resting tremor (HP:0002322)3.38696403
33Progressive cerebellar ataxia (HP:0002073)3.38379482
34Nail dystrophy (HP:0008404)3.34324833
35Action tremor (HP:0002345)3.26115787
36Focal dystonia (HP:0004373)3.25221168
37Stereotypic behavior (HP:0000733)3.21724715
38Truncal ataxia (HP:0002078)3.20700445
39Urinary bladder sphincter dysfunction (HP:0002839)3.19990545
40Postural instability (HP:0002172)3.16908508
41Supranuclear gaze palsy (HP:0000605)3.15230654
42Dysdiadochokinesis (HP:0002075)3.14477277
43Impaired smooth pursuit (HP:0007772)3.13730847
44Fragile skin (HP:0001030)3.07239745
45Craniofacial dystonia (HP:0012179)3.06790962
46Abnormal eating behavior (HP:0100738)3.03808114
47Acute lymphatic leukemia (HP:0006721)3.03405425
48Ankyloglossia (HP:0010296)3.02691393
49Premature rupture of membranes (HP:0001788)2.95458135
50Selective tooth agenesis (HP:0001592)2.93935691
51Dysmetria (HP:0001310)2.93835637
52Palmoplantar hyperkeratosis (HP:0000972)2.92713540
53Distal upper limb amyotrophy (HP:0007149)2.90852175
54Upper limb amyotrophy (HP:0009129)2.90852175
55Alopecia of scalp (HP:0002293)2.90199532
56Scanning speech (HP:0002168)2.90020398
57Urinary urgency (HP:0000012)2.90009666
58Bradykinesia (HP:0002067)2.85558240
59Ridged nail (HP:0001807)2.83267386
60Pointed chin (HP:0000307)2.80871036
61Amblyopia (HP:0000646)2.78918334
62Dysmetric saccades (HP:0000641)2.74905490
63Distal lower limb amyotrophy (HP:0008944)2.74664033
64Palmar hyperkeratosis (HP:0010765)2.71431093
65Abnormality of ocular smooth pursuit (HP:0000617)2.60863011
66Abnormality of the lower motor neuron (HP:0002366)2.60361411
67Spastic gait (HP:0002064)2.54628070
68Mutism (HP:0002300)2.51982680
69Abnormality of oral frenula (HP:0000190)2.51042657
70Hyperventilation (HP:0002883)2.50064545
71Abnormal blistering of the skin (HP:0008066)2.46224022
72Protrusio acetabuli (HP:0003179)2.45228015
73Polygenic inheritance (HP:0010982)2.43338519
74Spinal canal stenosis (HP:0003416)2.41422181
75Hand muscle atrophy (HP:0009130)2.41263464
76Impaired vibratory sensation (HP:0002495)2.39964775
77Difficulty climbing stairs (HP:0003551)2.38443451
78Limb dystonia (HP:0002451)2.38421533
79Shallow orbits (HP:0000586)2.38280186
80Natal tooth (HP:0000695)2.36309319
81Abnormality of binocular vision (HP:0011514)2.34111663
82Diplopia (HP:0000651)2.34111663
83Hypoplasia of dental enamel (HP:0006297)2.32789258
84Hemiplegia (HP:0002301)2.30665039
85Hyperacusis (HP:0010780)2.30118000
86Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.29101299
87Progressive inability to walk (HP:0002505)2.23239200
88Pterygium (HP:0001059)2.22914703
89Intention tremor (HP:0002080)2.20110681
90Insomnia (HP:0100785)2.19818338
91Lower limb amyotrophy (HP:0007210)2.19768197
92Epileptiform EEG discharges (HP:0011182)2.17459694
93Aplasia involving bones of the extremities (HP:0009825)2.16078403
94Aplasia involving bones of the upper limbs (HP:0009823)2.16078403
95Aplasia of the phalanges of the hand (HP:0009802)2.16078403
96Abnormality of saccadic eye movements (HP:0000570)2.12843945
97Achilles tendon contracture (HP:0001771)2.11710058
98Clonus (HP:0002169)2.11589278
99Coronal craniosynostosis (HP:0004440)2.10960099
100Abnormal EKG (HP:0003115)2.09252917
101Ulnar bowing (HP:0003031)2.09191439
102Ankle contracture (HP:0006466)2.08602268
103Hemiparesis (HP:0001269)2.08023001
104Status epilepticus (HP:0002133)2.07339173
105Incomplete penetrance (HP:0003829)2.06370153
106EEG with generalized epileptiform discharges (HP:0011198)2.06292900
107Genetic anticipation (HP:0003743)2.04573612
108Iris hypopigmentation (HP:0007730)2.04269071
109Short nail (HP:0001799)2.04169156
110Follicular hyperkeratosis (HP:0007502)2.04104997
111Rigidity (HP:0002063)2.01379148
112Abnormality of the salivary glands (HP:0010286)1.99985673
113Arterial tortuosity (HP:0005116)1.98316458
114Lower limb asymmetry (HP:0100559)1.96208637
115Split foot (HP:0001839)1.95615747
116Ventricular fibrillation (HP:0001663)1.94594101
117Pili torti (HP:0003777)1.93604064
118Gait ataxia (HP:0002066)1.93248459
119Spinal rigidity (HP:0003306)1.92577722
120Right ventricular cardiomyopathy (HP:0011663)1.92442594
121Obstructive sleep apnea (HP:0002870)1.91331981
122Fetal akinesia sequence (HP:0001989)1.91116058
123Limb ataxia (HP:0002070)1.90487033
124Hypsarrhythmia (HP:0002521)1.89987590
125Neuronal loss in central nervous system (HP:0002529)1.89985267
126Psychosis (HP:0000709)1.89157841
127Megalencephaly (HP:0001355)1.88259076
128Bronchomalacia (HP:0002780)1.88126560
129Vascular tortuosity (HP:0004948)1.87959208
130Inability to walk (HP:0002540)1.83598950
131Excessive salivation (HP:0003781)1.83587061
132Drooling (HP:0002307)1.83587061
133Ocular albinism (HP:0001107)1.82576105
134Lower limb muscle weakness (HP:0007340)1.82345091
135Abnormality of the periventricular white matter (HP:0002518)1.80882672
136Advanced eruption of teeth (HP:0006288)1.79260814
137Abnormality of the Achilles tendon (HP:0005109)1.77575173
138Generalized myoclonic seizures (HP:0002123)1.77198313
139Sparse scalp hair (HP:0002209)1.76435271
140Protruding tongue (HP:0010808)1.75449277
141Broad metatarsal (HP:0001783)1.75343287
142Generalized hypotonia (HP:0001290)1.74563678
143Vertebral arch anomaly (HP:0008438)1.74547916
144Polyphagia (HP:0002591)1.74201236
145Delusions (HP:0000746)1.72620091
146Unsteady gait (HP:0002317)1.72239228
147Chronic otitis media (HP:0000389)1.70394542
148Inappropriate behavior (HP:0000719)1.69994163
149Hydroureter (HP:0000072)1.69765997
150Sparse eyelashes (HP:0000653)1.69537405
151Absent speech (HP:0001344)1.69519457
152Prolonged QT interval (HP:0001657)1.68886982
153Apathy (HP:0000741)1.68788673
154Deep palmar crease (HP:0006191)1.67938871
155Bladder diverticulum (HP:0000015)1.65701823
156Spinal cord compression (HP:0002176)1.65591133
157Turricephaly (HP:0000262)1.64367273
158Long palpebral fissure (HP:0000637)1.64020586
159Distal lower limb muscle weakness (HP:0009053)1.63706756
160Cerebral hypomyelination (HP:0006808)1.62784683
161Oral leukoplakia (HP:0002745)1.61907908
162Distal sensory impairment (HP:0002936)1.61003728
163Diminished motivation (HP:0000745)1.60413201
164Arnold-Chiari malformation (HP:0002308)1.60362684
165Insidious onset (HP:0003587)1.59408209
166Termporal pattern (HP:0011008)1.59408209
167Wormian bones (HP:0002645)1.59362348
168Tetraplegia (HP:0002445)1.59027712
169Vertebral compression fractures (HP:0002953)1.56408972

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.30047839
2NTRK34.25176324
3MAP3K93.46664873
4RIPK43.41500435
5LATS23.25536743
6EPHA22.78375758
7DAPK22.61804589
8FES2.58757018
9MINK12.48258616
10CAMKK12.47873690
11MAP3K122.47684169
12MAP3K42.42681624
13KSR22.27946872
14DAPK12.26481002
15MST1R2.23560916
16PRKD32.15584872
17MAP2K72.12703775
18PTK22.10744308
19TNIK2.10353230
20ARAF2.04594841
21CDK192.02302507
22MET1.99608025
23MAP3K131.95512711
24PDGFRA1.86511914
25CAMKK21.83719528
26SIK21.81670410
27NTRK21.79699834
28TRIB31.67441075
29CDK51.56757035
30RAF11.49558529
31PAK61.47459017
32MAP2K41.44509322
33NTRK11.44459103
34MARK11.43824726
35TESK11.43573954
36PAK41.41539545
37KSR11.41183723
38EPHB21.36391757
39TAOK11.35509289
40TTN1.29761992
41LIMK11.24153488
42PRPF4B1.20312819
43PAK21.13830020
44SIK11.13376170
45MOS1.12294729
46CAMK11.08612945
47TNK21.07441022
48PIM21.06364318
49IRAK31.05618437
50MAP3K21.04232805
51SCYL21.02998553
52BMPR21.02449350
53SMG11.01183263
54MAPK131.01173885
55PLK21.00963862
56ICK1.00329189
57UHMK10.98114062
58PRKCG0.95177132
59ROCK20.94770013
60ERBB40.94079255
61LMTK20.93238678
62BRSK10.91943188
63NEK10.87661166
64GRK50.86876854
65CDK180.85697293
66CASK0.85589946
67CAMK2G0.83613525
68CDK150.82784173
69PRKG20.82474491
70STK110.82180709
71CCNB10.76947229
72CDK140.76845894
73BMX0.76352112
74MAP3K10.75775638
75PDK10.75305264
76SIK30.75241598
77STK380.74936588
78CDK11A0.74615978
79MYLK0.73356274
80SGK20.72870163
81SGK2230.71765955
82SGK4940.71765955
83MARK20.71074001
84ALK0.69657517
85LATS10.69343387
86TAOK20.69127278
87TYRO30.67657474
88PTK2B0.67359838
89RET0.67349858
90PRKCH0.66841191
91PNCK0.66404244
92KIT0.66066835
93PDPK10.64943463
94PINK10.64765528
95CAMK2A0.64178801
96ADRBK20.62166578
97SGK10.61577044
98SGK30.61200085
99BUB10.59194492
100CDK120.59064790
101CAMK2B0.58653918
102ABL20.58399774
103SYK0.57704863
104ROCK10.57170020
105BRAF0.55875921
106PAK10.52422832
107IRAK20.51825707
108AURKA0.49194175
109CAMK40.48614638
110DYRK1A0.48312981
111MTOR0.48242854
112NME10.47908625
113FLT30.47773396
114DAPK30.46794790
115ILK0.46729062
116TSSK60.46703411
117DDR20.46284588
118DMPK0.45698198
119MAP3K60.45523814
120RIPK10.44957339
121RPS6KA30.44881222
122PHKG10.44719868
123PHKG20.44719868
124PDGFRB0.42375961
125MAP3K80.42347916
126FYN0.40486983
127NME20.39869601
128RPS6KA20.39852515
129MAPK100.36671922
130EEF2K0.35330659
131MAP3K70.34390271
132MAPKAPK50.34116908
133PRKCZ0.31973000
134HCK0.31367600
135PRKCB0.30292267
136MUSK0.29920779
137GRK60.29904951
138OXSR10.29128416
139PRKCA0.24960492
140CAMK2D0.24257600
141CAMK1G0.24045352
142NEK60.22851972
143PRKCE0.22083779
144PRKD20.21074780
145MAP2K10.19546723

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.63000010
2Nicotine addiction_Homo sapiens_hsa050333.58790563
3Synaptic vesicle cycle_Homo sapiens_hsa047213.31622932
4Morphine addiction_Homo sapiens_hsa050322.92853872
5Circadian entrainment_Homo sapiens_hsa047132.88980704
6Amphetamine addiction_Homo sapiens_hsa050312.81102212
7Long-term potentiation_Homo sapiens_hsa047202.80656039
8GABAergic synapse_Homo sapiens_hsa047272.79211090
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66399503
10Glutamatergic synapse_Homo sapiens_hsa047242.63338003
11Dopaminergic synapse_Homo sapiens_hsa047282.43163544
12Cocaine addiction_Homo sapiens_hsa050302.27132485
13Cholinergic synapse_Homo sapiens_hsa047252.11141038
14Salivary secretion_Homo sapiens_hsa049702.10907590
15Vitamin B6 metabolism_Homo sapiens_hsa007502.03762408
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93366995
17Insulin secretion_Homo sapiens_hsa049111.90588324
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87119116
19ECM-receptor interaction_Homo sapiens_hsa045121.86215142
20Gastric acid secretion_Homo sapiens_hsa049711.85310972
21Renin secretion_Homo sapiens_hsa049241.82648838
22Oxytocin signaling pathway_Homo sapiens_hsa049211.76108283
23Calcium signaling pathway_Homo sapiens_hsa040201.75624616
24Taste transduction_Homo sapiens_hsa047421.67482316
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65040465
26Long-term depression_Homo sapiens_hsa047301.63221582
27Serotonergic synapse_Homo sapiens_hsa047261.62923461
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.58894923
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.51474475
30Focal adhesion_Homo sapiens_hsa045101.42420563
31GnRH signaling pathway_Homo sapiens_hsa049121.42135296
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40792886
33Hippo signaling pathway_Homo sapiens_hsa043901.39696308
34Gap junction_Homo sapiens_hsa045401.37172560
35cAMP signaling pathway_Homo sapiens_hsa040241.34916357
36Collecting duct acid secretion_Homo sapiens_hsa049661.33625786
37Glioma_Homo sapiens_hsa052141.20439778
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18175716
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17107434
40Proteoglycans in cancer_Homo sapiens_hsa052051.16327669
41Adherens junction_Homo sapiens_hsa045201.14729322
42Prion diseases_Homo sapiens_hsa050201.14555712
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13045492
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06842600
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05438188
46Estrogen signaling pathway_Homo sapiens_hsa049151.02591799
47Type II diabetes mellitus_Homo sapiens_hsa049301.02346962
48Phototransduction_Homo sapiens_hsa047441.00631006
49Oocyte meiosis_Homo sapiens_hsa041140.99243481
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97265474
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96538838
52Bladder cancer_Homo sapiens_hsa052190.94955029
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94579536
54Tight junction_Homo sapiens_hsa045300.94491802
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92956783
56Wnt signaling pathway_Homo sapiens_hsa043100.92233416
57ErbB signaling pathway_Homo sapiens_hsa040120.90792535
58Alcoholism_Homo sapiens_hsa050340.90630633
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90344572
60Vibrio cholerae infection_Homo sapiens_hsa051100.89341408
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.86011923
62Non-small cell lung cancer_Homo sapiens_hsa052230.83705822
63Small cell lung cancer_Homo sapiens_hsa052220.83686818
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83546772
65Type I diabetes mellitus_Homo sapiens_hsa049400.83440134
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.81092191
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79275869
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79116175
69Melanogenesis_Homo sapiens_hsa049160.77627649
70Amoebiasis_Homo sapiens_hsa051460.77152660
71Cardiac muscle contraction_Homo sapiens_hsa042600.76113175
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.74196041
73VEGF signaling pathway_Homo sapiens_hsa043700.73267128
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72989475
75Thyroid hormone synthesis_Homo sapiens_hsa049180.72009059
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71534395
77MicroRNAs in cancer_Homo sapiens_hsa052060.70236088
78MAPK signaling pathway_Homo sapiens_hsa040100.69802160
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69788499
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68602218
81Renal cell carcinoma_Homo sapiens_hsa052110.67947941
82Chronic myeloid leukemia_Homo sapiens_hsa052200.67515222
83Pancreatic secretion_Homo sapiens_hsa049720.66534402
84Basal cell carcinoma_Homo sapiens_hsa052170.66335161
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64853709
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62420145
87Nitrogen metabolism_Homo sapiens_hsa009100.62264598
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61284647
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61132101
90Biosynthesis of amino acids_Homo sapiens_hsa012300.60688906
91Hedgehog signaling pathway_Homo sapiens_hsa043400.60430282
92Choline metabolism in cancer_Homo sapiens_hsa052310.59586255
93Chemokine signaling pathway_Homo sapiens_hsa040620.58509022
94Melanoma_Homo sapiens_hsa052180.56050298
95Axon guidance_Homo sapiens_hsa043600.55480335
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54189279
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54151911
98Rap1 signaling pathway_Homo sapiens_hsa040150.53457834
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53345042
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.52625750
101Inositol phosphate metabolism_Homo sapiens_hsa005620.52106561
102Dorso-ventral axis formation_Homo sapiens_hsa043200.51211370
103Pathways in cancer_Homo sapiens_hsa052000.51194063
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50998207
105Dilated cardiomyopathy_Homo sapiens_hsa054140.50298656
106Platelet activation_Homo sapiens_hsa046110.49761407
107Arginine and proline metabolism_Homo sapiens_hsa003300.49005842
108African trypanosomiasis_Homo sapiens_hsa051430.48067760
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47840752
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47294726
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46873846
112mTOR signaling pathway_Homo sapiens_hsa041500.46403530
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45728601
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45549887
115Shigellosis_Homo sapiens_hsa051310.44888092
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44838431
117Glucagon signaling pathway_Homo sapiens_hsa049220.44643249
118Ras signaling pathway_Homo sapiens_hsa040140.44366920
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44319794
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43815663
121Endocytosis_Homo sapiens_hsa041440.40248663
122Circadian rhythm_Homo sapiens_hsa047100.38161678
123B cell receptor signaling pathway_Homo sapiens_hsa046620.36617923
124Thyroid cancer_Homo sapiens_hsa052160.33720363
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33345965
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.32174183
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31353845
128Parkinsons disease_Homo sapiens_hsa050120.30636378
129Alzheimers disease_Homo sapiens_hsa050100.29958187
130Endometrial cancer_Homo sapiens_hsa052130.29248622
131Insulin signaling pathway_Homo sapiens_hsa049100.28361529
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24994316
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24098830
134N-Glycan biosynthesis_Homo sapiens_hsa005100.22088555
135Colorectal cancer_Homo sapiens_hsa052100.21630765

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