SH2D3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.70667170
2leukocyte aggregation (GO:0070486)6.34224019
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.09610471
4negative regulation of cell killing (GO:0031342)6.09610471
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.98938024
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.98938024
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.92873997
8regulation of B cell receptor signaling pathway (GO:0050855)5.80774709
9positive thymic T cell selection (GO:0045059)5.52699938
10antigen processing and presentation of endogenous antigen (GO:0019883)5.35586392
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.33674587
12positive regulation by organism of defense response of other organism involved in symbiotic interact5.33674587
13modulation by symbiont of host immune response (GO:0052553)5.33674587
14positive regulation by symbiont of host defense response (GO:0052509)5.33674587
15modulation by symbiont of host defense response (GO:0052031)5.33674587
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.33674587
17regulation of gamma-delta T cell differentiation (GO:0045586)5.30728817
18response to interleukin-15 (GO:0070672)5.19687925
19negative thymic T cell selection (GO:0045060)5.19376496
20negative T cell selection (GO:0043383)5.13910525
21regulation of gamma-delta T cell activation (GO:0046643)4.95671737
22cellular response to interleukin-15 (GO:0071350)4.84604936
23detection of other organism (GO:0098543)4.75757740
24thymic T cell selection (GO:0045061)4.71005647
25neutrophil activation involved in immune response (GO:0002283)4.69513125
26positive T cell selection (GO:0043368)4.61686883
27cellular extravasation (GO:0045123)4.61244399
28endothelial tube morphogenesis (GO:0061154)4.60649670
29morphogenesis of an endothelium (GO:0003159)4.60649670
30interferon-gamma production (GO:0032609)4.44182905
31macrophage activation involved in immune response (GO:0002281)4.35291065
32regulation of B cell differentiation (GO:0045577)4.31166432
33T cell selection (GO:0045058)4.20434037
34B cell receptor signaling pathway (GO:0050853)4.17809794
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.02430788
36positive regulation of B cell differentiation (GO:0045579)3.98223831
37response to peptidoglycan (GO:0032494)3.91648185
38positive regulation of lamellipodium assembly (GO:0010592)3.90596827
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.88380300
40regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.83136420
41detection of external biotic stimulus (GO:0098581)3.80422672
42T cell migration (GO:0072678)3.79374477
43antigen receptor-mediated signaling pathway (GO:0050851)3.77759355
44negative regulation of phagocytosis (GO:0050765)3.75213505
45T cell receptor signaling pathway (GO:0050852)3.72187993
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.71965118
47regulation of interferon-beta biosynthetic process (GO:0045357)3.70992190
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.68254083
49response to host immune response (GO:0052572)3.64529268
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.64529268
51regulation of mast cell degranulation (GO:0043304)3.63893707
52leukocyte cell-cell adhesion (GO:0007159)3.63717018
53negative regulation of T cell mediated immunity (GO:0002710)3.61321878
54leukocyte migration involved in inflammatory response (GO:0002523)3.59366790
55T cell homeostasis (GO:0043029)3.58179506
56sequestering of actin monomers (GO:0042989)3.57639023
57T cell costimulation (GO:0031295)3.56863462
58myeloid cell activation involved in immune response (GO:0002275)3.53012224
59lymphocyte costimulation (GO:0031294)3.52082931
60negative regulation of erythrocyte differentiation (GO:0045647)3.50877045
61microglial cell activation (GO:0001774)3.48160119
62positive regulation of lamellipodium organization (GO:1902745)3.46753162
63regulation of dendritic cell antigen processing and presentation (GO:0002604)3.43585880
64regulation of isotype switching to IgG isotypes (GO:0048302)3.43103449
65negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.42220562
66positive regulation of granulocyte differentiation (GO:0030854)3.40051765
67regulation of mast cell activation involved in immune response (GO:0033006)3.39630600
68tolerance induction (GO:0002507)3.35725850
69regulation of myeloid leukocyte mediated immunity (GO:0002886)3.33631288
70regulation of T cell tolerance induction (GO:0002664)3.33462778
71cellular response to type I interferon (GO:0071357)3.33011481
72type I interferon signaling pathway (GO:0060337)3.33011481
73positive regulation of tolerance induction (GO:0002645)3.31384609
74granulocyte activation (GO:0036230)3.30986402
75activated T cell proliferation (GO:0050798)3.30224040
76response to host defenses (GO:0052200)3.30202747
77response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30202747
78response to host (GO:0075136)3.30202747
79detection of biotic stimulus (GO:0009595)3.28731493
80neutrophil mediated immunity (GO:0002446)3.26190875
81response to muramyl dipeptide (GO:0032495)3.26110629
82detection of molecule of bacterial origin (GO:0032490)3.25266395
83regulation of mast cell activation (GO:0033003)3.24775067
84macrophage activation (GO:0042116)3.23372731
85leukocyte degranulation (GO:0043299)3.21754832
86regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.21114502
87regulation of T cell receptor signaling pathway (GO:0050856)3.19495759
88regulation of response to interferon-gamma (GO:0060330)3.18277990
89cellular response to zinc ion (GO:0071294)3.13090862
90B cell mediated immunity (GO:0019724)3.12607488
91regulation of leukocyte degranulation (GO:0043300)3.11554838
92germinal center formation (GO:0002467)3.09272951
93regulation of antigen processing and presentation (GO:0002577)3.08312858
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.08146432
95lymphocyte homeostasis (GO:0002260)3.06928172
96regulation of natural killer cell mediated immunity (GO:0002715)3.03295544
97regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.03295544
98megakaryocyte development (GO:0035855)3.02846943
99immune response-activating cell surface receptor signaling pathway (GO:0002429)3.01362151
100regulation of T-helper 2 cell differentiation (GO:0045628)3.01016494
101mast cell activation (GO:0045576)2.97269310
102regulation of alpha-beta T cell proliferation (GO:0046640)2.96996788
103regulation of T cell mediated cytotoxicity (GO:0001914)2.94624446
104respiratory burst (GO:0045730)2.93612791
105interferon-gamma-mediated signaling pathway (GO:0060333)2.93422014
106negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92996907
107negative regulation of alpha-beta T cell activation (GO:0046636)2.91892269
108positive regulation of isotype switching (GO:0045830)2.91778738
109positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.89476146
110negative regulation of innate immune response (GO:0045824)2.89153604
111positive regulation of mast cell activation (GO:0033005)2.88424539
112positive regulation of antigen processing and presentation (GO:0002579)2.87537910
113negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.85333352
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.84881544
115immunoglobulin mediated immune response (GO:0016064)2.84737604
116regulation of interleukin-12 biosynthetic process (GO:0045075)2.84543505
117regulation of defense response to virus by virus (GO:0050690)2.83442118
118negative regulation of lymphocyte mediated immunity (GO:0002707)2.80125576
119regulation of type I interferon-mediated signaling pathway (GO:0060338)2.79950589
120NIK/NF-kappaB signaling (GO:0038061)2.79092588
121regulation of granulocyte differentiation (GO:0030852)2.78847376
122regulation of tolerance induction (GO:0002643)2.76128146
123antigen processing and presentation via MHC class Ib (GO:0002475)2.74410585
124leukocyte homeostasis (GO:0001776)2.74362397
125negative regulation of T-helper cell differentiation (GO:0045623)2.73639986
126negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.73639986
127actin nucleation (GO:0045010)2.72557741
128barbed-end actin filament capping (GO:0051016)2.71654715
129mature B cell differentiation (GO:0002335)2.70757483
130response to protozoan (GO:0001562)2.70669332
131leukocyte tethering or rolling (GO:0050901)2.67363223
132negative regulation of interleukin-12 production (GO:0032695)2.66500159
133natural killer cell activation (GO:0030101)2.65790920
134detection of bacterium (GO:0016045)2.60543081
135defense response to protozoan (GO:0042832)2.60489494
136neutrophil activation (GO:0042119)2.60241429
137negative regulation of leukocyte mediated immunity (GO:0002704)2.59611713
138positive regulation of DNA recombination (GO:0045911)2.58241035
139regulation of leukocyte mediated cytotoxicity (GO:0001910)2.57860318
140regulation of B cell mediated immunity (GO:0002712)2.57230582
141response to type I interferon (GO:0034340)2.57106793
142blood vessel maturation (GO:0001955)2.56869762
143macrophage differentiation (GO:0030225)2.56313469
144positive regulation of B cell activation (GO:0050871)2.55700038
145angiogenesis involved in wound healing (GO:0060055)2.55110155
146lymph node development (GO:0048535)2.54804343
147positive regulation of B cell mediated immunity (GO:0002714)2.53093635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.08423509
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.56614833
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.54761515
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.84883493
5MYC_22102868_ChIP-Seq_BL_Human3.68123347
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.21354292
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.12072881
8* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.09297679
9VDR_21846776_ChIP-Seq_THP-1_Human3.08263993
10RUNX_20019798_ChIP-Seq_JUKART_Human3.07025358
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.05868850
12SCL_19346495_ChIP-Seq_HPC-7_Human3.03447168
13MAF_26560356_Chip-Seq_TH1_Human2.93954091
14* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.87769360
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.85174377
16* MYB_26560356_Chip-Seq_TH2_Human2.73379458
17UTX_26944678_Chip-Seq_JUKART_Human2.73083303
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68529906
19* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.63054318
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.60669043
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48172403
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.47863873
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.43448302
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39545941
25* TCF7_22412390_ChIP-Seq_EML_Mouse2.38117637
26* MYB_26560356_Chip-Seq_TH1_Human2.35834613
27E2F7_22180533_ChIP-Seq_HELA_Human2.33303136
28* SPI1_23547873_ChIP-Seq_NB4_Human2.32355876
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31148865
30VDR_24763502_ChIP-Seq_THP-1_Human2.18001006
31* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.16747675
32* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.16285881
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.15411636
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13911244
35NOTCH1_21737748_ChIP-Seq_TLL_Human2.12835420
36IRF8_27001747_Chip-Seq_BMDM_Mouse2.12252637
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11069491
38SPI1_23127762_ChIP-Seq_K562_Human2.10100809
39KDM2B_26808549_Chip-Seq_SUP-B15_Human2.05014583
40* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04306246
41KDM2B_26808549_Chip-Seq_DND41_Human1.98987717
42* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98616829
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93970447
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92647554
45MAF_26560356_Chip-Seq_TH2_Human1.90477198
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88237337
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.83655013
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82483012
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77469453
50* GATA3_27048872_Chip-Seq_THYMUS_Human1.70693866
51CIITA_25753668_ChIP-Seq_RAJI_Human1.68073183
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66355514
53* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63894427
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59617388
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50544507
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47817248
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.47583616
58VDR_24787735_ChIP-Seq_THP-1_Human1.46763267
59* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44298406
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39468015
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.39173197
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38994965
63* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38878776
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.33990156
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.29612281
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29511507
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29460261
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29326468
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28105763
70* GATA2_21666600_ChIP-Seq_HMVEC_Human1.23172057
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19840810
72BCOR_27268052_Chip-Seq_Bcells_Human1.17395345
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16821363
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16431777
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16357882
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16233955
77PU_27001747_Chip-Seq_BMDM_Mouse1.14805234
78LXR_22292898_ChIP-Seq_THP-1_Human1.13914989
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12758579
80DROSHA_22980978_ChIP-Seq_HELA_Human1.09862644
81* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09661403
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08170001
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06605916
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04425684
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02605193
86GATA3_26560356_Chip-Seq_TH2_Human1.02241905
87* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01229724
88GATA1_19941826_ChIP-Seq_K562_Human1.00563216
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99975766
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99683446
91* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98067781
92BCL6_27268052_Chip-Seq_Bcells_Human0.96183927
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95076443
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94145378
95* P68_20966046_ChIP-Seq_HELA_Human0.93976510
96NCOR1_26117541_ChIP-Seq_K562_Human0.93856138
97SA1_27219007_Chip-Seq_ERYTHROID_Human0.92646365
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92466816
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92216702
100* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91751375
101GATA2_19941826_ChIP-Seq_K562_Human0.90739102
102DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90373446
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89045875
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87923826
105FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86677115
106* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86048976
107CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84999665
108SPI1_20517297_ChIP-Seq_HL60_Human0.83341814
109FOXP3_21729870_ChIP-Seq_TREG_Human0.82095833
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81482111
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79616760
112* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79146211
113ELF1_20517297_ChIP-Seq_JURKAT_Human0.76414631
114SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.76067798
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.73804704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.70292856
2MP0005671_abnormal_response_to3.53737042
3MP0001835_abnormal_antigen_presentation3.36906234
4MP0002396_abnormal_hematopoietic_system3.04260901
5* MP0001800_abnormal_humoral_immune3.02141724
6MP0009785_altered_susceptibility_to2.91139568
7MP0003724_increased_susceptibility_to2.89283589
8MP0000685_abnormal_immune_system2.88877634
9MP0003303_peritoneal_inflammation2.82324363
10* MP0002420_abnormal_adaptive_immunity2.72854561
11MP0005387_immune_system_phenotype2.72579509
12MP0001790_abnormal_immune_system2.72579509
13MP0009278_abnormal_bone_marrow2.71456578
14* MP0001819_abnormal_immune_cell2.70634590
15MP0002398_abnormal_bone_marrow2.65699576
16* MP0002452_abnormal_antigen_presenting2.55419564
17MP0005000_abnormal_immune_tolerance2.53121422
18* MP0002723_abnormal_immune_serum2.52430630
19MP0003436_decreased_susceptibility_to2.49087801
20MP0005025_abnormal_response_to2.39005353
21MP0004808_abnormal_hematopoietic_stem2.36435983
22* MP0000716_abnormal_immune_system2.26841551
23MP0000465_gastrointestinal_hemorrhage2.19717101
24MP0002405_respiratory_system_inflammati2.18700752
25MP0002419_abnormal_innate_immunity2.16955044
26MP0005464_abnormal_platelet_physiology2.10398171
27MP0002722_abnormal_immune_system2.08290294
28* MP0000689_abnormal_spleen_morphology2.07273504
29MP0000703_abnormal_thymus_morphology2.06415600
30MP0010368_abnormal_lymphatic_system2.04734895
31* MP0002429_abnormal_blood_cell1.94738806
32MP0004510_myositis1.92046689
33MP0009333_abnormal_splenocyte_physiolog1.89682777
34MP0005167_abnormal_blood-brain_barrier1.89246485
35MP0001545_abnormal_hematopoietic_system1.85066979
36MP0005397_hematopoietic_system_phenotyp1.85066979
37MP0003300_gastrointestinal_ulcer1.81451386
38MP0006082_CNS_inflammation1.80119514
39MP0003828_pulmonary_edema1.75904924
40MP0010155_abnormal_intestine_physiology1.71895114
41MP0002166_altered_tumor_susceptibility1.69301130
42MP0001879_abnormal_lymphatic_vessel1.68696030
43MP0001873_stomach_inflammation1.67018686
44MP0002148_abnormal_hypersensitivity_rea1.66747786
45MP0003191_abnormal_cellular_cholesterol1.66541401
46MP0003172_abnormal_lysosome_physiology1.58844496
47MP0001845_abnormal_inflammatory_respons1.58326376
48MP0008260_abnormal_autophagy1.53389069
49MP0002837_dystrophic_cardiac_calcinosis1.48143820
50MP0003866_abnormal_defecation1.47635059
51MP0000858_altered_metastatic_potential1.38761473
52MP0001853_heart_inflammation1.38388529
53MP0004947_skin_inflammation1.38294227
54MP0000343_altered_response_to1.38147049
55MP0002933_joint_inflammation1.37795863
56MP0004381_abnormal_hair_follicle1.35850224
57MP0001851_eye_inflammation1.27007293
58MP0002006_tumorigenesis1.20434210
59MP0003448_altered_tumor_morphology1.16594304
60MP0003690_abnormal_glial_cell1.13198336
61MP0001533_abnormal_skeleton_physiology1.09590270
62MP0003279_aneurysm1.08573592
63MP0002138_abnormal_hepatobiliary_system1.04621871
64MP0008961_abnormal_basal_metabolism1.02637987
65MP0002019_abnormal_tumor_incidence1.02078578
66MP0002132_abnormal_respiratory_system1.00869338
67MP0003693_abnormal_embryo_hatching1.00235588
68MP0001986_abnormal_taste_sensitivity0.99394868
69MP0008469_abnormal_protein_level0.98620997
70MP0000767_abnormal_smooth_muscle0.96625052
71MP0003075_altered_response_to0.95361067
72MP0005174_abnormal_tail_pigmentation0.95327911
73MP0002998_abnormal_bone_remodeling0.94952780
74MP0005075_abnormal_melanosome_morpholog0.92423004
75MP0003183_abnormal_peptide_metabolism0.91809804
76MP0003077_abnormal_cell_cycle0.89130377
77MP0001663_abnormal_digestive_system0.89071268
78MP0002277_abnormal_respiratory_mucosa0.88926216
79MP0009764_decreased_sensitivity_to0.88541432
80MP0000490_abnormal_crypts_of0.88076652
81MP0004130_abnormal_muscle_cell0.85865709
82MP0000249_abnormal_blood_vessel0.85155256
83MP0004084_abnormal_cardiac_muscle0.84979430
84MP0000015_abnormal_ear_pigmentation0.83563922
85MP0008874_decreased_physiological_sensi0.81472425
86MP0005310_abnormal_salivary_gland0.81091846
87MP0002332_abnormal_exercise_endurance0.80277739
88MP0005084_abnormal_gallbladder_morpholo0.80124817
89MP0003943_abnormal_hepatobiliary_system0.79004445
90MP0010630_abnormal_cardiac_muscle0.76286943
91MP0005164_abnormal_response_to0.74558766
92MP0005451_abnormal_body_composition0.72837015
93MP0006054_spinal_hemorrhage0.72064920
94MP0003045_fibrosis0.71197210
95MP0005390_skeleton_phenotype0.69138691
96MP0008004_abnormal_stomach_pH0.66355720
97MP0002925_abnormal_cardiovascular_devel0.65850425
98MP0005535_abnormal_body_temperature0.65524991
99MP0003221_abnormal_cardiomyocyte_apopto0.63586673
100MP0005385_cardiovascular_system_phenoty0.63509101
101MP0001544_abnormal_cardiovascular_syste0.63509101
102MP0002127_abnormal_cardiovascular_syste0.60467651
103MP0004883_abnormal_blood_vessel0.60098676
104MP0005166_decreased_susceptibility_to0.59111674
105MP0004147_increased_porphyrin_level0.58848117
106MP0004484_altered_response_of0.57010723
107MP0009763_increased_sensitivity_to0.56937787
108MP0003566_abnormal_cell_adhesion0.56871882
109MP0009765_abnormal_xenobiotic_induced0.56285570
110MP0002928_abnormal_bile_duct0.56097866
111MP0003787_abnormal_imprinting0.55567265
112MP0000313_abnormal_cell_death0.55301109
113MP0002653_abnormal_ependyma_morphology0.54870485
114MP0002095_abnormal_skin_pigmentation0.54595260
115MP0003111_abnormal_nucleus_morphology0.54385826
116MP0005023_abnormal_wound_healing0.53163225
117MP0008007_abnormal_cellular_replicative0.53064781
118MP0004215_abnormal_myocardial_fiber0.51461527
119MP0002133_abnormal_respiratory_system0.51229214
120MP0005388_respiratory_system_phenotype0.51229214
121MP0000604_amyloidosis0.50910591
122MP0002822_catalepsy0.50901150
123MP0002972_abnormal_cardiac_muscle0.49991049
124MP0003646_muscle_fatigue0.49915293
125MP0008995_early_reproductive_senescence0.49732121
126MP0000266_abnormal_heart_morphology0.49552843
127MP0005058_abnormal_lysosome_morphology0.47746281
128MP0002693_abnormal_pancreas_physiology0.47677651
129MP0005381_digestive/alimentary_phenotyp0.46762779

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)5.41397903
2Recurrent abscess formation (HP:0002722)4.97130257
3Elevated erythrocyte sedimentation rate (HP:0003565)4.72399523
4Myositis (HP:0100614)4.65660922
5Abnormality of the nasal mucosa (HP:0000433)4.54312224
6Eczematoid dermatitis (HP:0000976)4.53273816
7Chronic otitis media (HP:0000389)4.31330438
8T lymphocytopenia (HP:0005403)4.27602869
9Recurrent bronchitis (HP:0002837)4.20600177
10Abnormality of T cell number (HP:0011839)4.10912498
11IgM deficiency (HP:0002850)4.03815748
12Recurrent bacterial skin infections (HP:0005406)4.02052607
13Recurrent fungal infections (HP:0002841)4.00272279
14Meningitis (HP:0001287)3.95953996
15Agammaglobulinemia (HP:0004432)3.81499570
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.78367930
17Chronic obstructive pulmonary disease (HP:0006510)3.77329122
18Obstructive lung disease (HP:0006536)3.77329122
19Panhypogammaglobulinemia (HP:0003139)3.71440652
20Cellulitis (HP:0100658)3.70043840
21Abnormality of the fingertips (HP:0001211)3.62359583
22Nasal polyposis (HP:0100582)3.55427175
23Abnormality of T cells (HP:0002843)3.48853190
24Recurrent viral infections (HP:0004429)3.41302993
25Hypochromic microcytic anemia (HP:0004840)3.39694130
26Hematochezia (HP:0002573)3.39173713
27Gastrointestinal inflammation (HP:0004386)3.33254040
28Stomatitis (HP:0010280)3.32501716
29Inflammation of the large intestine (HP:0002037)3.29241953
30Recurrent cutaneous fungal infections (HP:0011370)3.21413143
31Chronic mucocutaneous candidiasis (HP:0002728)3.21413143
32Mediastinal lymphadenopathy (HP:0100721)3.20888712
33Hemoptysis (HP:0002105)3.13341173
34Hypochromic anemia (HP:0001931)3.09102004
35Recurrent skin infections (HP:0001581)3.06181951
36Orchitis (HP:0100796)3.05101839
37Prolonged bleeding time (HP:0003010)3.04846195
38Lymphopenia (HP:0001888)3.00112933
39Vasculitis (HP:0002633)2.98395697
40Thyroiditis (HP:0100646)2.97588508
41Increased IgM level (HP:0003496)2.92800166
42Abnormality of cells of the lymphoid lineage (HP:0012140)2.89232292
43Pustule (HP:0200039)2.85744911
44Chest pain (HP:0100749)2.82510360
45IgG deficiency (HP:0004315)2.81398681
46Encephalitis (HP:0002383)2.81292913
47Severe combined immunodeficiency (HP:0004430)2.80172526
48Episodic fever (HP:0001954)2.78065885
49Optic neuritis (HP:0100653)2.74827110
50Retrobulbar optic neuritis (HP:0100654)2.74827110
51Combined immunodeficiency (HP:0005387)2.73878331
52Leukocytosis (HP:0001974)2.71455831
53Autoimmune thrombocytopenia (HP:0001973)2.67544468
54Verrucae (HP:0200043)2.66221013
55Papilloma (HP:0012740)2.66221013
56Gingival bleeding (HP:0000225)2.64672293
57Chronic sinusitis (HP:0011109)2.64606811
58Polycythemia (HP:0001901)2.63899525
59Colitis (HP:0002583)2.61074752
60Recurrent sinusitis (HP:0011108)2.60093533
61Hypergammaglobulinemia (HP:0010702)2.59887151
62Recurrent gram-negative bacterial infections (HP:0005420)2.58714083
63Abnormality of eosinophils (HP:0001879)2.57346272
64Epistaxis (HP:0000421)2.55366055
65Microcytic anemia (HP:0001935)2.50249136
66Thrombocytosis (HP:0001894)2.45393707
67Abnormality of T cell physiology (HP:0011840)2.45158243
68Bronchitis (HP:0012387)2.44524520
69Abnormality of macrophages (HP:0004311)2.44419398
70Pulmonary embolism (HP:0002204)2.44308248
71Recurrent pneumonia (HP:0006532)2.38088358
72B lymphocytopenia (HP:0010976)2.37917593
73Abnormality of B cell number (HP:0010975)2.37917593
74Abnormality of the peritoneum (HP:0002585)2.36444067
75Gingivitis (HP:0000230)2.33760205
76Peritonitis (HP:0002586)2.33014374
77Arterial thrombosis (HP:0004420)2.30913816
78Gastrointestinal stroma tumor (HP:0100723)2.30166278
79Eosinophilia (HP:0001880)2.28020747
80Emphysema (HP:0002097)2.24854297
81Sepsis (HP:0100806)2.23524534
82Purpura (HP:0000979)2.22613860
83Papilledema (HP:0001085)2.21812083
84Anorexia (HP:0002039)2.21547072
85Lymphoma (HP:0002665)2.18839744
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.18373479
87Interstitial pulmonary disease (HP:0006530)2.17459723
88Hemiplegia (HP:0002301)2.16988761
89Recurrent lower respiratory tract infections (HP:0002783)2.16165151
90Abnormality of the endocardium (HP:0004306)2.16040997
91Keratoconjunctivitis sicca (HP:0001097)2.11143056
92Vertigo (HP:0002321)2.07432518
93Pulmonary infiltrates (HP:0002113)2.07304059
94Restrictive lung disease (HP:0002091)2.06760000
95Chronic diarrhea (HP:0002028)2.06004246
96Amyloidosis (HP:0011034)2.01513512
97Gangrene (HP:0100758)2.00770676
98Skin ulcer (HP:0200042)1.99368869
99Osteomyelitis (HP:0002754)1.99101091
100Increased IgE level (HP:0003212)1.97466986
101Abnormality of the pleura (HP:0002103)1.97389489
102Joint swelling (HP:0001386)1.94899549
103Keratitis (HP:0000491)1.93940110
104Acute hepatic failure (HP:0006554)1.93539009
105Urticaria (HP:0001025)1.93172269
106Granulocytopenia (HP:0001913)1.91653274
107Petechiae (HP:0000967)1.91529591
108Abnormal platelet volume (HP:0011876)1.91034422
109Viral hepatitis (HP:0006562)1.90061256
110Ventricular tachycardia (HP:0004756)1.89952968
111Gastrointestinal infarctions (HP:0005244)1.88514506
112Abnormal platelet function (HP:0011869)1.88232940
113Impaired platelet aggregation (HP:0003540)1.88232940
114Glomerulopathy (HP:0100820)1.87969880
115Autoimmune hemolytic anemia (HP:0001890)1.86413952
116Keratoconjunctivitis (HP:0001096)1.85043377
117Bicuspid aortic valve (HP:0001647)1.82485836
118Centrally nucleated skeletal muscle fibers (HP:0003687)1.81575080
119Acute myeloid leukemia (HP:0004808)1.78345458
120Skin rash (HP:0000988)1.78246027
121Recurrent otitis media (HP:0000403)1.77567046
122Basal cell carcinoma (HP:0002671)1.75841651
123Abnormality of the prostate (HP:0008775)1.75746499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.27431019
2KDR3.98392322
3TIE13.21116215
4TXK3.02714156
5ITK2.75975578
6ZAP702.68383214
7STK102.45280746
8TEC2.35982432
9TGFBR22.31275066
10JAK32.31076998
11BTK2.24399600
12BLK2.21764498
13EEF2K2.13345626
14PRPF4B2.07462445
15IRAK42.04039532
16ERN11.85892073
17KIT1.83118991
18CSK1.79827654
19TYK21.79124471
20FGFR41.70431795
21MAP3K121.67312612
22SIK31.66104986
23GRK61.64478691
24IKBKE1.63718643
25FES1.63396839
26MAP2K31.58596705
27SYK1.57877262
28TBK11.53907467
29CLK11.49327712
30MAP3K101.41764123
31PKN21.41547897
32JAK11.39240372
33HCK1.37489928
34LCK1.35312543
35MARK31.32756003
36SIK21.28015376
37TGFBR11.24976878
38TAOK31.23001114
39EPHB11.21835037
40CSF1R1.20375092
41FGFR31.15644145
42MAP3K31.13850949
43NLK1.09972566
44NEK21.06534691
45LRRK21.03169129
46TRIB31.02861892
47PTK2B1.02832398
48MAP3K10.98449543
49CDK190.98275457
50STK240.96836749
51PRKCH0.92686781
52MAP2K60.89239441
53MAP3K140.86803050
54LYN0.85818885
55TAOK10.83083701
56MAPK70.80206707
57YES10.80110645
58DYRK1B0.79785737
59TTN0.79519797
60CDK90.77819649
61BMPR20.75303745
62PRKD20.72404328
63EPHA30.72305863
64RPS6KA40.69721706
65KSR20.69563238
66MATK0.69369896
67MAP3K60.69252259
68MAPK120.67690633
69FLT30.67657972
70CAMKK10.66958414
71PIM10.64476262
72DMPK0.64092442
73PRKCQ0.62467703
74MAP2K40.62387467
75JAK20.59977432
76MAPK40.59801208
77PDPK10.56452276
78PIK3CG0.53271978
79CDK120.52853316
80MYLK0.51928953
81CDC42BPA0.50871523
82MAP3K70.50719173
83MAP3K130.50613047
84GRK10.49952580
85PAK40.49919949
86PTK60.49895953
87PRKG20.49128069
88MAP3K110.47653453
89MARK20.47413405
90STK40.46680245
91RIPK40.46511351
92TNK20.45982708
93MAPKAPK30.44683821
94IKBKB0.43878392
95DAPK20.43736048
96RPS6KA20.43663556
97CDK80.41663734
98RPS6KA60.41303680
99IRAK10.41219960
100CAMKK20.41133559
101CDK40.40903933
102MAPK110.40856318
103TAOK20.40398147
104CHUK0.40204841
105RET0.40030853
106NME20.39008502
107STK380.38346606
108PDK10.38169677
109CSNK1G30.37136450
110FGR0.36983900
111RAF10.36723706
112PRKCZ0.36565212
113BUB10.35955317
114MAPKAPK20.35704001
115SGK30.35173767
116SIK10.35172843
117ILK0.35042794
118SGK20.34119776
119SMG10.33870679
120MAP3K50.33260625
121FYN0.32378670
122CSNK1A1L0.31783423
123HIPK20.31668025
124IRAK20.31228558
125PRKD10.31014447
126CAMK40.31005741
127STK110.30293069
128MELK0.28546917
129TESK20.26447091
130CSNK1G10.26157226
131MAPK130.25731615
132RPS6KL10.23747125
133RPS6KC10.23747125

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.06302202
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.77694622
3B cell receptor signaling pathway_Homo sapiens_hsa046622.62296622
4T cell receptor signaling pathway_Homo sapiens_hsa046602.49404320
5Leishmaniasis_Homo sapiens_hsa051402.35460357
6Hematopoietic cell lineage_Homo sapiens_hsa046402.16828944
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13118602
8Type I diabetes mellitus_Homo sapiens_hsa049402.11564857
9Measles_Homo sapiens_hsa051622.10769673
10Osteoclast differentiation_Homo sapiens_hsa043802.07312595
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.06788492
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.00190251
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.99321914
14Viral myocarditis_Homo sapiens_hsa054161.98269648
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.97110194
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.95168281
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.69464080
18Shigellosis_Homo sapiens_hsa051311.68582731
19Antigen processing and presentation_Homo sapiens_hsa046121.65888744
20Chemokine signaling pathway_Homo sapiens_hsa040621.59763851
21Graft-versus-host disease_Homo sapiens_hsa053321.58374895
22Platelet activation_Homo sapiens_hsa046111.48167557
23Acute myeloid leukemia_Homo sapiens_hsa052211.45434519
24Toxoplasmosis_Homo sapiens_hsa051451.41668870
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41565256
26Herpes simplex infection_Homo sapiens_hsa051681.40111831
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36936806
28Pancreatic cancer_Homo sapiens_hsa052121.35313673
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.33014886
30Hepatitis B_Homo sapiens_hsa051611.31968924
31VEGF signaling pathway_Homo sapiens_hsa043701.30931372
32Phagosome_Homo sapiens_hsa041451.28351926
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28066436
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27708470
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.22260679
36Chronic myeloid leukemia_Homo sapiens_hsa052201.20759406
37Influenza A_Homo sapiens_hsa051641.16242217
38Colorectal cancer_Homo sapiens_hsa052101.14316107
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13856766
40Notch signaling pathway_Homo sapiens_hsa043301.13485086
41Allograft rejection_Homo sapiens_hsa053301.11748068
42TNF signaling pathway_Homo sapiens_hsa046681.11488815
43Apoptosis_Homo sapiens_hsa042101.09011653
44African trypanosomiasis_Homo sapiens_hsa051431.07869690
45Rheumatoid arthritis_Homo sapiens_hsa053231.07627139
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06394569
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03505888
48Salmonella infection_Homo sapiens_hsa051321.02439959
49HTLV-I infection_Homo sapiens_hsa051661.01958738
50Epstein-Barr virus infection_Homo sapiens_hsa051691.01498423
51Non-small cell lung cancer_Homo sapiens_hsa052230.98148035
52Tuberculosis_Homo sapiens_hsa051520.97674683
53Base excision repair_Homo sapiens_hsa034100.94837955
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92461509
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92281002
56Staphylococcus aureus infection_Homo sapiens_hsa051500.90075352
57Malaria_Homo sapiens_hsa051440.89435418
58Prolactin signaling pathway_Homo sapiens_hsa049170.89259779
59Cell cycle_Homo sapiens_hsa041100.88667589
60Hepatitis C_Homo sapiens_hsa051600.84121166
61Pertussis_Homo sapiens_hsa051330.83174444
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82887689
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82134919
64FoxO signaling pathway_Homo sapiens_hsa040680.78061462
65Rap1 signaling pathway_Homo sapiens_hsa040150.77192165
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76691962
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76405076
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.73942772
69Endocytosis_Homo sapiens_hsa041440.73904876
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73268114
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72924935
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70489938
73Asthma_Homo sapiens_hsa053100.69262651
74Insulin resistance_Homo sapiens_hsa049310.67744735
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66694504
76MAPK signaling pathway_Homo sapiens_hsa040100.66638524
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63913682
78Endometrial cancer_Homo sapiens_hsa052130.63307238
79Legionellosis_Homo sapiens_hsa051340.63167091
80Viral carcinogenesis_Homo sapiens_hsa052030.63049087
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63021456
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60601245
83GnRH signaling pathway_Homo sapiens_hsa049120.60439485
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60327193
85Dorso-ventral axis formation_Homo sapiens_hsa043200.60259076
86Regulation of autophagy_Homo sapiens_hsa041400.58495518
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58311170
88Small cell lung cancer_Homo sapiens_hsa052220.58137101
89p53 signaling pathway_Homo sapiens_hsa041150.57878447
90Other glycan degradation_Homo sapiens_hsa005110.57211621
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56513216
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.56293604
93Renal cell carcinoma_Homo sapiens_hsa052110.55836257
94Autoimmune thyroid disease_Homo sapiens_hsa053200.53696812
95Pathways in cancer_Homo sapiens_hsa052000.51903780
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49403855
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.48932458
98MicroRNAs in cancer_Homo sapiens_hsa052060.48592081
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.48196781
100Spliceosome_Homo sapiens_hsa030400.46548266
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46235711
102Adherens junction_Homo sapiens_hsa045200.44854213
103Choline metabolism in cancer_Homo sapiens_hsa052310.43866413
104DNA replication_Homo sapiens_hsa030300.43791174
105mRNA surveillance pathway_Homo sapiens_hsa030150.42974535
106Long-term potentiation_Homo sapiens_hsa047200.42569321
107Focal adhesion_Homo sapiens_hsa045100.42248870
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.41969712
109mTOR signaling pathway_Homo sapiens_hsa041500.40888143
110RNA degradation_Homo sapiens_hsa030180.40445329
111Thyroid cancer_Homo sapiens_hsa052160.40414943
112Cholinergic synapse_Homo sapiens_hsa047250.40351308
113Insulin signaling pathway_Homo sapiens_hsa049100.40277470
114Type II diabetes mellitus_Homo sapiens_hsa049300.39950278
115Inositol phosphate metabolism_Homo sapiens_hsa005620.39465671
116HIF-1 signaling pathway_Homo sapiens_hsa040660.38117558
117Oxytocin signaling pathway_Homo sapiens_hsa049210.36655977
118Morphine addiction_Homo sapiens_hsa050320.36153861
119Ras signaling pathway_Homo sapiens_hsa040140.35350848
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32793979
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32791800

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