SGPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.46628322
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.46628322
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.46628322
4modulation by symbiont of host immune response (GO:0052553)5.46628322
5positive regulation by symbiont of host defense response (GO:0052509)5.46628322
6modulation by symbiont of host defense response (GO:0052031)5.46628322
7regulation of interferon-beta biosynthetic process (GO:0045357)4.93127594
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54224083
9eosinophil chemotaxis (GO:0048245)4.50520183
10positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.19687485
11limb bud formation (GO:0060174)4.08802242
12macrophage activation involved in immune response (GO:0002281)4.06085997
13keratinocyte development (GO:0003334)4.01361123
14positive regulation of interferon-alpha production (GO:0032727)4.00191729
15eosinophil migration (GO:0072677)3.93371155
16antigen processing and presentation of endogenous antigen (GO:0019883)3.92775571
17regulation of interferon-alpha production (GO:0032647)3.79508505
18low-density lipoprotein particle clearance (GO:0034383)3.68896496
19regulation of keratinocyte proliferation (GO:0010837)3.63886383
20platelet dense granule organization (GO:0060155)3.60699465
21positive regulation of antigen processing and presentation (GO:0002579)3.59494082
22apoptotic cell clearance (GO:0043277)3.58267189
23regulation of dendritic cell antigen processing and presentation (GO:0002604)3.56222922
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.52968866
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52968866
26cardiac right ventricle morphogenesis (GO:0003215)3.51849413
27negative regulation of axon guidance (GO:1902668)3.51208893
28neutrophil activation involved in immune response (GO:0002283)3.49188730
29response to host immune response (GO:0052572)3.38576019
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.38576019
31positive regulation of glycoprotein biosynthetic process (GO:0010560)3.36288529
32I-kappaB phosphorylation (GO:0007252)3.34533412
33regulation of cholesterol storage (GO:0010885)3.31045456
34kidney morphogenesis (GO:0060993)3.30907301
35DNA double-strand break processing (GO:0000729)3.30102639
36negative regulation of axon extension involved in axon guidance (GO:0048843)3.26837391
37cell adhesion mediated by integrin (GO:0033627)3.26129291
38regulation of cilium movement (GO:0003352)3.24417081
39microglial cell activation (GO:0001774)3.23061672
40immunoglobulin mediated immune response (GO:0016064)3.19876022
41intestinal epithelial cell development (GO:0060576)3.16113441
42positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.15085594
43negative regulation of keratinocyte proliferation (GO:0010839)3.14007378
44regulation of antigen processing and presentation (GO:0002577)3.13215794
45presynaptic membrane assembly (GO:0097105)3.12627045
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11925605
47response to host (GO:0075136)3.11925605
48response to host defenses (GO:0052200)3.11925605
49ectoderm development (GO:0007398)3.06772964
50zinc ion transport (GO:0006829)3.06018231
51C4-dicarboxylate transport (GO:0015740)3.05338470
52positive regulation of p38MAPK cascade (GO:1900745)3.05142216
53UDP-N-acetylglucosamine metabolic process (GO:0006047)3.04250301
54prostate gland growth (GO:0060736)3.04146984
55response to peptidoglycan (GO:0032494)3.03187386
56natural killer cell mediated immunity (GO:0002228)3.03123748
57natural killer cell mediated cytotoxicity (GO:0042267)3.03123748
58positive regulation of glycoprotein metabolic process (GO:1903020)2.95447928
59pinocytosis (GO:0006907)2.94388082
60positive regulation of protein autophosphorylation (GO:0031954)2.92070147
61glial cell proliferation (GO:0014009)2.92003686
62lactate metabolic process (GO:0006089)2.91726235
63tryptophan catabolic process (GO:0006569)2.90792409
64indole-containing compound catabolic process (GO:0042436)2.90792409
65indolalkylamine catabolic process (GO:0046218)2.90792409
66negative regulation of execution phase of apoptosis (GO:1900118)2.89952563
67negative regulation of translation, ncRNA-mediated (GO:0040033)2.89171953
68regulation of translation, ncRNA-mediated (GO:0045974)2.89171953
69negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.89171953
70synapsis (GO:0007129)2.88913747
71branching involved in labyrinthine layer morphogenesis (GO:0060670)2.87979338
72positive regulation of interferon-beta production (GO:0032728)2.84975259
73response to muramyl dipeptide (GO:0032495)2.84364847
74adhesion of symbiont to host cell (GO:0044650)2.83017581
75virion attachment to host cell (GO:0019062)2.83017581
76heme transport (GO:0015886)2.82663672
77water-soluble vitamin biosynthetic process (GO:0042364)2.81327474
78intraciliary transport (GO:0042073)2.80057192
79macrophage activation (GO:0042116)2.78415392
80L-alpha-amino acid transmembrane transport (GO:1902475)2.77962222
81negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77840334
82regulation of interleukin-8 biosynthetic process (GO:0045414)2.75136826
83transcytosis (GO:0045056)2.75036751
84ganglion development (GO:0061548)2.74565222
85nonmotile primary cilium assembly (GO:0035058)2.73782363
86NIK/NF-kappaB signaling (GO:0038061)2.72427955
87adhesion of symbiont to host (GO:0044406)2.68227583
88dorsal/ventral axis specification (GO:0009950)2.67125658
89positive regulation of cholesterol efflux (GO:0010875)2.66723964
90presynaptic membrane organization (GO:0097090)2.66592221
91transepithelial transport (GO:0070633)2.65440451
92retinal ganglion cell axon guidance (GO:0031290)2.65233765
93replication fork processing (GO:0031297)2.65227089
94negative regulation of lipid storage (GO:0010888)2.65124843
95positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.64651874
96positive regulation of leukocyte degranulation (GO:0043302)2.63283431
97regulation of cytokine secretion involved in immune response (GO:0002739)2.62884388
98negative regulation of systemic arterial blood pressure (GO:0003085)2.62350032
99regulation of membrane protein ectodomain proteolysis (GO:0051043)2.62264534
100regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.61784123
101granulocyte activation (GO:0036230)2.60540707
102photoreceptor cell maintenance (GO:0045494)2.59768866
103response to lipoprotein particle (GO:0055094)2.58459276
104regulation of protein glycosylation (GO:0060049)2.56014455
105kynurenine metabolic process (GO:0070189)2.55985059
106detection of molecule of bacterial origin (GO:0032490)2.54748780
107neutrophil activation (GO:0042119)2.54560574
108positive regulation of macrophage cytokine production (GO:0060907)2.54314494
109negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.53368439
110regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.53005815
111regulation of mononuclear cell migration (GO:0071675)2.51649979
112tryptophan metabolic process (GO:0006568)2.51481152
113nucleobase catabolic process (GO:0046113)2.51456900
114positive regulation of natural killer cell differentiation (GO:0032825)2.51376704
115regulation of interleukin-12 biosynthetic process (GO:0045075)2.50525577
116respiratory burst (GO:0045730)2.50134571
117negative regulation of neurological system process (GO:0031645)2.49470037
118response to pheromone (GO:0019236)2.49398333
119pyrimidine nucleobase catabolic process (GO:0006208)2.48095500
120positive regulation of sterol transport (GO:0032373)2.47192906
121positive regulation of cholesterol transport (GO:0032376)2.47192906
122auditory receptor cell differentiation (GO:0042491)2.46557114
123positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.45377448
124regulation of integrin activation (GO:0033623)2.44384165
125cilium morphogenesis (GO:0060271)2.44148787
126regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.42592001
127response to laminar fluid shear stress (GO:0034616)2.42381692
128regulation of axon guidance (GO:1902667)2.41282283
129cellular response to interferon-alpha (GO:0035457)2.41147666
130negative chemotaxis (GO:0050919)2.40783100
131regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.40154339
132resolution of meiotic recombination intermediates (GO:0000712)2.39836889
133nodal signaling pathway (GO:0038092)2.39686768
134positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.39615640
135keratan sulfate catabolic process (GO:0042340)2.38775205
136positive regulation of gamma-delta T cell activation (GO:0046645)2.38421795
137hydrogen peroxide biosynthetic process (GO:0050665)2.38080270
138negative regulation of granulocyte differentiation (GO:0030853)2.37014092
139proline transport (GO:0015824)2.36565132
140Golgi transport vesicle coating (GO:0048200)2.35915522
141COPI coating of Golgi vesicle (GO:0048205)2.35915522
142myeloid cell activation involved in immune response (GO:0002275)2.35610528
143plasma lipoprotein particle clearance (GO:0034381)2.35351740
144positive regulation of natural killer cell activation (GO:0032816)2.34272454
145B cell mediated immunity (GO:0019724)2.33184052
146regulation of integrin-mediated signaling pathway (GO:2001044)2.32889966
147somatic diversification of immune receptors via somatic mutation (GO:0002566)2.32493403
148somatic hypermutation of immunoglobulin genes (GO:0016446)2.32493403
149indolalkylamine metabolic process (GO:0006586)2.32156294
150polyol catabolic process (GO:0046174)2.32059614
151response to nitrosative stress (GO:0051409)2.31477339
152regulation of B cell receptor signaling pathway (GO:0050855)2.31381540
153phospholipid efflux (GO:0033700)2.31027897
154cytokine secretion (GO:0050663)2.30891109
155regulation of interferon-beta production (GO:0032648)2.30866819
156JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.30448749
157hyaluronan catabolic process (GO:0030214)2.30263354
158neural tube formation (GO:0001841)2.30039640
159regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.29542193
160vitamin biosynthetic process (GO:0009110)2.29090887
161regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.28960413
162fatty acid elongation (GO:0030497)2.28952737
163lipoprotein transport (GO:0042953)2.28625787
164regulation of podosome assembly (GO:0071801)2.28053998
165peptidyl-cysteine modification (GO:0018198)2.27000320
166positive regulation of heat generation (GO:0031652)2.26881229
167positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.26299411
168lipopolysaccharide-mediated signaling pathway (GO:0031663)2.25859122
169cellular response to vitamin (GO:0071295)2.25580908
170dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.25220347
171protein K11-linked deubiquitination (GO:0035871)2.25120439
172positive regulation of chemokine biosynthetic process (GO:0045080)2.24766856
173cilium assembly (GO:0042384)2.23938991
174branched-chain amino acid catabolic process (GO:0009083)2.23720105
175production of molecular mediator involved in inflammatory response (GO:0002532)2.23700956
176negative regulation of dendrite development (GO:2000171)2.23518961
177regulation of glucokinase activity (GO:0033131)2.23390426
178regulation of hexokinase activity (GO:1903299)2.23390426
179macroautophagy (GO:0016236)2.22987037
180regulation of protein autophosphorylation (GO:0031952)2.22959879
181olfactory bulb development (GO:0021772)2.22809196
182cilium organization (GO:0044782)2.22477760
183mannose metabolic process (GO:0006013)2.21011052
184regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.20679076
185vascular smooth muscle contraction (GO:0014829)2.20312948
186positive regulation of chemokine production (GO:0032722)2.20160480
187cellular response to sterol (GO:0036315)2.20074254
188regulation of leukocyte degranulation (GO:0043300)2.20056647
189glucosamine-containing compound metabolic process (GO:1901071)2.19405507
190L-serine transport (GO:0015825)2.18714018
1913-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.17971414
192purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.17971414
193signal peptide processing (GO:0006465)2.17791269
194negative regulation of DNA-dependent DNA replication (GO:2000104)2.17533213
195detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.14768617
196sterol biosynthetic process (GO:0016126)2.13704184
197regulation of mitotic spindle checkpoint (GO:1903504)2.12491928
198regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.12491928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.66056525
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.48937732
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.94757613
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.49806592
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.41448021
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.37366126
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.34049588
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.33303784
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.14159844
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09383034
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78130785
12ZNF274_21170338_ChIP-Seq_K562_Hela2.75556898
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73807169
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.70218011
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.68483641
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63517955
17GBX2_23144817_ChIP-Seq_PC3_Human2.61721196
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.58041599
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51018736
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44010865
21RXR_22158963_ChIP-Seq_LIVER_Mouse2.35827063
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34077654
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30877340
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29501500
25PPARA_22158963_ChIP-Seq_LIVER_Mouse2.28920657
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26341036
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26219931
28BP1_19119308_ChIP-ChIP_Hs578T_Human2.21095086
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.20968448
30LXR_22158963_ChIP-Seq_LIVER_Mouse2.18822850
31P300_19829295_ChIP-Seq_ESCs_Human2.17319585
32* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.16859603
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16183750
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08995666
35VDR_22108803_ChIP-Seq_LS180_Human1.99214726
36* CLOCK_20551151_ChIP-Seq_293T_Human1.97438239
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96822229
38* PIAS1_25552417_ChIP-Seq_VCAP_Human1.96024872
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95141590
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88601603
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88518633
42FUS_26573619_Chip-Seq_HEK293_Human1.88393406
43BCAT_22108803_ChIP-Seq_LS180_Human1.84666502
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.79505120
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78478852
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.77570167
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.76710635
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76335026
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76316942
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74463449
51SMAD4_21799915_ChIP-Seq_A2780_Human1.73714008
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73209798
53TAF15_26573619_Chip-Seq_HEK293_Human1.73103106
54EWS_26573619_Chip-Seq_HEK293_Human1.72685707
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.71963128
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70530985
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.69582385
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68187162
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67135255
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64312216
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61027588
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59624101
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57522481
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55517699
65* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.55479931
66ER_23166858_ChIP-Seq_MCF-7_Human1.55163528
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54790971
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53672414
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51474723
70AR_25329375_ChIP-Seq_VCAP_Human1.49977957
71* PU_27001747_Chip-Seq_BMDM_Mouse1.49933632
72TCF4_22108803_ChIP-Seq_LS180_Human1.48280217
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47644690
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47078487
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46316663
76VDR_21846776_ChIP-Seq_THP-1_Human1.46243592
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.46211476
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.45695801
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45124363
80* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44417080
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44185776
82VDR_24763502_ChIP-Seq_THP-1_Human1.43628190
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43457972
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41802184
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41449067
86ELK1_19687146_ChIP-ChIP_HELA_Human1.41361888
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41197037
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41188915
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41028016
90* FOXO3_23340844_ChIP-Seq_DLD1_Human1.38758881
91AHR_22903824_ChIP-Seq_MCF-7_Human1.38090162
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37751577
93VDR_24787735_ChIP-Seq_THP-1_Human1.37380107
94* SPI1_23127762_ChIP-Seq_K562_Human1.35116040
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33845879
96STAT3_23295773_ChIP-Seq_U87_Human1.32876588
97ELK3_25401928_ChIP-Seq_HUVEC_Human1.32847965
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32067810
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.31459500
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.31143445
101SPI1_23547873_ChIP-Seq_NB4_Human1.30933362
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30786154
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30572968
104* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30129177
105NANOG_19829295_ChIP-Seq_ESCs_Human1.29885474
106SOX2_19829295_ChIP-Seq_ESCs_Human1.29885474
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.29417117
108TFEB_21752829_ChIP-Seq_HELA_Human1.28293713
109* TCF7_22412390_ChIP-Seq_EML_Mouse1.28233348
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28198391
111MAF_26560356_Chip-Seq_TH1_Human1.27752556
112IGF1R_20145208_ChIP-Seq_DFB_Human1.27702276
113* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27693482
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27231423
115RUNX1_22412390_ChIP-Seq_EML_Mouse1.27188117
116SMAD3_21741376_ChIP-Seq_HESCs_Human1.26439849
117TP53_18474530_ChIP-ChIP_U2OS_Human1.26408550
118STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25641284
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.25508697
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25282754
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25249762
122CDX2_22108803_ChIP-Seq_LS180_Human1.25168226
123MYB_26560356_Chip-Seq_TH2_Human1.24777794
124* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24144812
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23765445
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23642985
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23606511
128CBP_20019798_ChIP-Seq_JUKART_Human1.23606511
129* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23349878
130* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23349878
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.23321189
132E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22778937
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21833137
134SCL_19346495_ChIP-Seq_HPC-7_Human1.19657460
135TCF4_23295773_ChIP-Seq_U87_Human1.19549861
136ESR2_21235772_ChIP-Seq_MCF-7_Human1.19533937
137PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19328094
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18311302
139NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18174106
140* CRX_20693478_ChIP-Seq_RETINA_Mouse1.17990264
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17216408
142NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17216408
143STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16892952
144KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16441592
145KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14318715
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14281017
147FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14018699
148MYC_22102868_ChIP-Seq_BL_Human1.13995242
149* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13825628
150E2F1_18555785_Chip-Seq_ESCs_Mouse1.13429614
151RUNX_20019798_ChIP-Seq_JUKART_Human1.13369080
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13323705
153CMYC_18555785_Chip-Seq_ESCs_Mouse1.13012039
154P53_22387025_ChIP-Seq_ESCs_Mouse1.12632087
155SOX2_20726797_ChIP-Seq_SW620_Human1.12183376
156GATA4_25053715_ChIP-Seq_YYC3_Human1.12073211
157GATA1_22025678_ChIP-Seq_K562_Human1.10842545
158TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10407416
159PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09546041
160NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09230804
161* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08958205
162SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08879905
163* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08458310
164RUNX2_22187159_ChIP-Seq_PCA_Human1.08424383
165E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08089082
166P300_18555785_Chip-Seq_ESCs_Mouse1.07937137
167WT1_19549856_ChIP-ChIP_CCG9911_Human1.07118747
168HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07004494
169TP53_16413492_ChIP-PET_HCT116_Human1.06411345
170SMAD4_21741376_ChIP-Seq_HESCs_Human1.05721737
171CJUN_26792858_Chip-Seq_BT549_Human1.05170500
172* GATA6_25053715_ChIP-Seq_YYC3_Human1.04695421
173* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03990255
174EP300_21415370_ChIP-Seq_HL-1_Mouse1.03121807
175GATA3_27048872_Chip-Seq_THYMUS_Human1.02689307
176GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02131778
177STAT3_18555785_Chip-Seq_ESCs_Mouse1.01701595
178NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01565495
179KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01420627
180RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01319105
181SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00981443
182CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00708693
183MYB_26560356_Chip-Seq_TH1_Human0.99899796
184FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99890489
185TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99042213
186VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98506578
187KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98296711
188SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98171223
189CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98166663
190P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97338679
191UTX_26944678_Chip-Seq_JUKART_Human0.97261085
192LXR_22292898_ChIP-Seq_THP-1_Human0.97063168
193RACK7_27058665_Chip-Seq_MCF-7_Human0.96842423
194BRD4_25478319_ChIP-Seq_HGPS_Human0.96774101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.19449649
2MP0005058_abnormal_lysosome_morphology3.52093064
3MP0001835_abnormal_antigen_presentation2.83054687
4MP0006082_CNS_inflammation2.73119766
5MP0003705_abnormal_hypodermis_morpholog2.71061717
6MP0000383_abnormal_hair_follicle2.60581975
7MP0009840_abnormal_foam_cell2.60519918
8MP0000569_abnormal_digit_pigmentation2.54184894
9MP0003172_abnormal_lysosome_physiology2.51324271
10MP0003436_decreased_susceptibility_to2.50194117
11MP0008438_abnormal_cutaneous_collagen2.48774424
12MP0009780_abnormal_chondrocyte_physiolo2.36691287
13MP0002102_abnormal_ear_morphology2.35943180
14MP0003300_gastrointestinal_ulcer2.32961079
15MP0003303_peritoneal_inflammation2.28753344
16MP0001984_abnormal_olfaction2.19724667
17MP0002736_abnormal_nociception_after2.18474723
18MP0003890_abnormal_embryonic-extraembry2.17316641
19MP0000647_abnormal_sebaceous_gland2.16425460
20MP0000685_abnormal_immune_system2.16317706
21MP0000427_abnormal_hair_cycle2.15216029
22MP0003191_abnormal_cellular_cholesterol2.09657864
23MP0002419_abnormal_innate_immunity1.99131770
24MP0003183_abnormal_peptide_metabolism1.96711223
25MP0004019_abnormal_vitamin_homeostasis1.92917580
26MP0002090_abnormal_vision1.89775262
27MP0008875_abnormal_xenobiotic_pharmacok1.88062743
28MP0005248_abnormal_Harderian_gland1.86802340
29MP0010352_gastrointestinal_tract_polyps1.86459327
30MP0005257_abnormal_intraocular_pressure1.86264625
31MP0002938_white_spotting1.82983727
32MP0001790_abnormal_immune_system1.73083261
33MP0005387_immune_system_phenotype1.73083261
34MP0003566_abnormal_cell_adhesion1.71843974
35MP0002877_abnormal_melanocyte_morpholog1.71674427
36MP0003718_maternal_effect1.71572859
37MP0005000_abnormal_immune_tolerance1.71392202
38* MP0000516_abnormal_urinary_system1.71182485
39* MP0005367_renal/urinary_system_phenotyp1.71182485
40MP0004947_skin_inflammation1.70433590
41MP0006072_abnormal_retinal_apoptosis1.62995057
42MP0005379_endocrine/exocrine_gland_phen1.61174046
43MP0005253_abnormal_eye_physiology1.61117853
44MP0002452_abnormal_antigen_presenting1.58738599
45MP0004510_myositis1.56680586
46MP0000372_irregular_coat_pigmentation1.56630567
47MP0001533_abnormal_skeleton_physiology1.56056886
48MP0005076_abnormal_cell_differentiation1.56008527
49MP0003941_abnormal_skin_development1.55092697
50MP0005025_abnormal_response_to1.55083045
51MP0005551_abnormal_eye_electrophysiolog1.54602959
52MP0005360_urolithiasis1.52603806
53MP0002751_abnormal_autonomic_nervous1.52292082
54MP0009785_altered_susceptibility_to1.51983312
55MP0001324_abnormal_eye_pigmentation1.51401956
56MP0002148_abnormal_hypersensitivity_rea1.50555802
57MP0010307_abnormal_tumor_latency1.48935492
58MP0002233_abnormal_nose_morphology1.48307302
59MP0003448_altered_tumor_morphology1.48297635
60MP0009278_abnormal_bone_marrow1.47840138
61MP0005464_abnormal_platelet_physiology1.47304759
62MP0004264_abnormal_extraembryonic_tissu1.43894982
63MP0005310_abnormal_salivary_gland1.42329392
64MP0001800_abnormal_humoral_immune1.41495602
65MP0005275_abnormal_skin_tensile1.40322866
66MP0008789_abnormal_olfactory_epithelium1.38195461
67MP0003136_yellow_coat_color1.38129430
68MP0002837_dystrophic_cardiac_calcinosis1.37840316
69MP0002282_abnormal_trachea_morphology1.37058602
70MP0003453_abnormal_keratinocyte_physiol1.32750668
71MP0008877_abnormal_DNA_methylation1.30817685
72MP0000604_amyloidosis1.28813592
73MP0000537_abnormal_urethra_morphology1.28187416
74MP0003252_abnormal_bile_duct1.27403917
75MP0001958_emphysema1.25594136
76MP0002723_abnormal_immune_serum1.25565617
77* MP0001845_abnormal_inflammatory_respons1.24577566
78MP0002234_abnormal_pharynx_morphology1.23590417
79MP0010234_abnormal_vibrissa_follicle1.22941174
80MP0003806_abnormal_nucleotide_metabolis1.22689941
81MP0002405_respiratory_system_inflammati1.21019566
82MP0005023_abnormal_wound_healing1.20376260
83MP0001819_abnormal_immune_cell1.18851699
84MP0001873_stomach_inflammation1.18709060
85MP0002098_abnormal_vibrissa_morphology1.18615534
86MP0002998_abnormal_bone_remodeling1.18070427
87MP0005671_abnormal_response_to1.17538793
88MP0000858_altered_metastatic_potential1.17369072
89MP0002420_abnormal_adaptive_immunity1.16744273
90MP0005646_abnormal_pituitary_gland1.16482185
91MP0010155_abnormal_intestine_physiology1.16306259
92MP0003937_abnormal_limbs/digits/tail_de1.14847251
93MP0008469_abnormal_protein_level1.14482606
94MP0003880_abnormal_central_pattern1.14449569
95MP0005395_other_phenotype1.13722541
96MP0002139_abnormal_hepatobiliary_system1.13315200
97MP0000371_diluted_coat_color1.13036305
98MP0005085_abnormal_gallbladder_physiolo1.12837055
99MP0001485_abnormal_pinna_reflex1.12140500
100MP0003195_calcinosis1.12100062
101MP0000377_abnormal_hair_follicle1.11991403
102MP0001764_abnormal_homeostasis1.10746951
103MP0002166_altered_tumor_susceptibility1.07783652
104MP0000609_abnormal_liver_physiology1.07430318
105MP0002163_abnormal_gland_morphology1.06162927
106MP0000613_abnormal_salivary_gland1.04579260
107MP0008058_abnormal_DNA_repair1.04328763
108MP0000566_synostosis1.04264791
109MP0002060_abnormal_skin_morphology1.04065900
110MP0005332_abnormal_amino_acid1.03512359
111MP0003011_delayed_dark_adaptation1.03336626
112MP0009764_decreased_sensitivity_to1.03188050
113MP0002909_abnormal_adrenal_gland1.01894854
114MP0001853_heart_inflammation1.00186155
115* MP0003091_abnormal_cell_migration1.00085632
116* MP0003755_abnormal_palate_morphology0.99555869
117MP0002138_abnormal_hepatobiliary_system0.97889848
118MP0000343_altered_response_to0.97799062
119MP0000778_abnormal_nervous_system0.97226595
120MP0008872_abnormal_physiological_respon0.95769018
121MP0004133_heterotaxia0.95700544
122MP0010329_abnormal_lipoprotein_level0.95569685
123MP0003075_altered_response_to0.95519831
124MP0001849_ear_inflammation0.95465470
125MP0001851_eye_inflammation0.94814932
126MP0005408_hypopigmentation0.94333146
127MP0000733_abnormal_muscle_development0.94303374
128MP0009384_cardiac_valve_regurgitation0.93915779
129MP0002111_abnormal_tail_morphology0.93091382
130MP0005391_vision/eye_phenotype0.92795778
131MP0006054_spinal_hemorrhage0.91957326
132MP0009333_abnormal_splenocyte_physiolog0.91128917
133MP0001216_abnormal_epidermal_layer0.88941302
134MP0002168_other_aberrant_phenotype0.86585786
135MP0003868_abnormal_feces_composition0.86576983
136MP0001968_abnormal_touch/_nociception0.85932197
137MP0009703_decreased_birth_body0.85241479
138* MP0005390_skeleton_phenotype0.85110230
139MP0003283_abnormal_digestive_organ0.84993762
140* MP0000716_abnormal_immune_system0.84286859
141MP0002006_tumorigenesis0.82917501
142MP0001348_abnormal_lacrimal_gland0.82823939
143MP0005365_abnormal_bile_salt0.82730354
144MP0001346_abnormal_lacrimal_gland0.82261357
145MP0005195_abnormal_posterior_eye0.80711151
146MP0005174_abnormal_tail_pigmentation0.80054794
147* MP0003795_abnormal_bone_structure0.79570715
148MP0009763_increased_sensitivity_to0.79435973
149MP0000462_abnormal_digestive_system0.78897526
150MP0003950_abnormal_plasma_membrane0.78789066
151MP0004782_abnormal_surfactant_physiolog0.78560988
152MP0000432_abnormal_head_morphology0.78069707
153MP0001529_abnormal_vocalization0.77982662
154MP0003690_abnormal_glial_cell0.77903362
155MP0001286_abnormal_eye_development0.77871926
156MP0004185_abnormal_adipocyte_glucose0.77759899
157MP0002933_joint_inflammation0.77479797
158MP0005197_abnormal_uvea_morphology0.77397025
159MP0009643_abnormal_urine_homeostasis0.77268078
160MP0005499_abnormal_olfactory_system0.77044693
161MP0005394_taste/olfaction_phenotype0.77044693
162MP0002277_abnormal_respiratory_mucosa0.76277716
163MP0001756_abnormal_urination0.75808446
164MP0003724_increased_susceptibility_to0.75769651
165MP0009053_abnormal_anal_canal0.75344184
166MP0000015_abnormal_ear_pigmentation0.74758622
167MP0000598_abnormal_liver_morphology0.74369229
168MP0001915_intracranial_hemorrhage0.74205507
169MP0001299_abnormal_eye_distance/0.74158110
170MP0005166_decreased_susceptibility_to0.71668434
171MP0010678_abnormal_skin_adnexa0.71360790
172MP0003119_abnormal_digestive_system0.70877279
173MP0004883_abnormal_blood_vessel0.70329649
174MP0003137_abnormal_impulse_conducting0.69798466
175MP0003045_fibrosis0.69632298
176MP0001666_abnormal_nutrient_absorption0.68781347
177* MP0002136_abnormal_kidney_physiology0.68778778
178MP0001293_anophthalmia0.68762662
179MP0003279_aneurysm0.68201915
180* MP0002429_abnormal_blood_cell0.67805421

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)4.72944745
2Ependymoma (HP:0002888)4.68763426
3Vacuolated lymphocytes (HP:0001922)4.49905302
4Eczematoid dermatitis (HP:0000976)4.23736364
5Systemic lupus erythematosus (HP:0002725)4.20251046
6Recurrent abscess formation (HP:0002722)4.08878143
7Dysostosis multiplex (HP:0000943)3.94636057
8Abnormality of the astrocytes (HP:0100707)3.87939676
9Astrocytoma (HP:0009592)3.87939676
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.78334268
11Abnormality of liposaccharide metabolism (HP:0010968)3.76655494
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.76655494
13Abnormality of glycolipid metabolism (HP:0010969)3.76655494
14Recurrent bacterial skin infections (HP:0005406)3.75701015
15Recurrent gram-negative bacterial infections (HP:0005420)3.74603605
16Urinary glycosaminoglycan excretion (HP:0003541)3.68163294
17Mucopolysacchariduria (HP:0008155)3.68163294
18Abnormality of mucopolysaccharide metabolism (HP:0011020)3.62487391
19Abnormality of polysaccharide metabolism (HP:0011012)3.62487391
20Abnormality of glycosaminoglycan metabolism (HP:0004371)3.62487391
21Abnormality of macrophages (HP:0004311)3.57230345
22Myocardial infarction (HP:0001658)3.53530475
23Intestinal atresia (HP:0011100)3.51235523
24Agnosia (HP:0010524)3.40503542
25Glioma (HP:0009733)3.37585362
26Disinhibition (HP:0000734)3.07123733
27Glomerulonephritis (HP:0000099)2.91700232
28Hematochezia (HP:0002573)2.86927847
29True hermaphroditism (HP:0010459)2.85896696
30Axonal loss (HP:0003447)2.83202781
31Gingivitis (HP:0000230)2.81756784
32Autoimmune thrombocytopenia (HP:0001973)2.78525429
33Hyperventilation (HP:0002883)2.78006907
34Complement deficiency (HP:0004431)2.74055007
35Recurrent skin infections (HP:0001581)2.71348447
36Cerebral aneurysm (HP:0004944)2.70838796
37Hypothermia (HP:0002045)2.70084454
38Periodontitis (HP:0000704)2.69172040
39Pancreatic cysts (HP:0001737)2.68688829
40Abnormality of proline metabolism (HP:0010907)2.67325239
41Hydroxyprolinuria (HP:0003080)2.67325239
42Esophageal varix (HP:0002040)2.62127762
43Cervical subluxation (HP:0003308)2.60428899
44Medial flaring of the eyebrow (HP:0010747)2.58483172
45Loss of speech (HP:0002371)2.57064944
46Abnormality of midbrain morphology (HP:0002418)2.56874866
47Molar tooth sign on MRI (HP:0002419)2.56874866
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.55738717
49Osteolytic defects of the hand bones (HP:0009699)2.55738717
50Hamartoma of the eye (HP:0010568)2.51093872
51Recurrent fungal infections (HP:0002841)2.50157587
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.48959536
53Abnormality of complement system (HP:0005339)2.47516723
54Pancreatic fibrosis (HP:0100732)2.43860699
55Chronic mucocutaneous candidiasis (HP:0002728)2.42454911
56Recurrent cutaneous fungal infections (HP:0011370)2.42454911
57Labial hypoplasia (HP:0000066)2.41213440
58Albinism (HP:0001022)2.40579438
59Vertebral compression fractures (HP:0002953)2.40327440
60Bifid tongue (HP:0010297)2.39110225
61Tetraparesis (HP:0002273)2.38666051
62Interstitial pulmonary disease (HP:0006530)2.37254301
63Colon cancer (HP:0003003)2.36207539
64Nephritis (HP:0000123)2.34977839
65Genital tract atresia (HP:0001827)2.33786216
66Nephronophthisis (HP:0000090)2.31969112
67Colitis (HP:0002583)2.30958313
68Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.30282685
69Vaginal atresia (HP:0000148)2.27349724
70Myositis (HP:0100614)2.24969052
71Peritonitis (HP:0002586)2.21467528
72Mediastinal lymphadenopathy (HP:0100721)2.21265749
73Aortic aneurysm (HP:0004942)2.20805353
74Hypoplastic female external genitalia (HP:0012815)2.20168743
75Orchitis (HP:0100796)2.19760169
76Abolished electroretinogram (ERG) (HP:0000550)2.17551666
77Hypoplastic labia majora (HP:0000059)2.16192775
78Thick nail (HP:0001805)2.15831749
79Renal hypoplasia (HP:0000089)2.14313487
80Congenital primary aphakia (HP:0007707)2.14227800
81Upper motor neuron abnormality (HP:0002127)2.14102961
82Abnormality of the vasculature of the conjunctiva (HP:0008054)2.12740590
83Premature rupture of membranes (HP:0001788)2.11454405
84Aqueductal stenosis (HP:0002410)2.10921920
85Peripheral demyelination (HP:0011096)2.09827343
86Gastrointestinal atresia (HP:0002589)2.07422146
87Cortical dysplasia (HP:0002539)2.06705332
88Abnormality of glutamine family amino acid metabolism (HP:0010902)2.06128623
89Xanthomatosis (HP:0000991)2.05504696
90Gait imbalance (HP:0002141)2.05237039
91Nuclear cataract (HP:0100018)2.04973945
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.04941787
93Pustule (HP:0200039)2.04651547
94Breast carcinoma (HP:0003002)2.03807264
95Pathologic fracture (HP:0002756)2.03507404
96Abnormality of the renal medulla (HP:0100957)2.03021171
97Abnormality of the labia minora (HP:0012880)2.02620993
98Increased CSF protein (HP:0002922)1.96870363
99Anencephaly (HP:0002323)1.95832105
100Intrahepatic cholestasis (HP:0001406)1.95738671
101Hemiparesis (HP:0001269)1.94744224
102Posterior subcapsular cataract (HP:0007787)1.94609743
103Abnormality of vitamin B metabolism (HP:0004340)1.94267261
104Abnormality of the renal cortex (HP:0011035)1.94176300
105Abnormality of methionine metabolism (HP:0010901)1.94035682
106Hypercholesterolemia (HP:0003124)1.93697400
107Oligodactyly (hands) (HP:0001180)1.93361513
108Nephrogenic diabetes insipidus (HP:0009806)1.92765266
109Chronic hepatic failure (HP:0100626)1.92579356
110Abnormality of the parathyroid morphology (HP:0011766)1.91837921
111Popliteal pterygium (HP:0009756)1.89003253
112Conjunctival telangiectasia (HP:0000524)1.88385197
113Aortic dissection (HP:0002647)1.88384239
114Thyroiditis (HP:0100646)1.87363934
115Gingival bleeding (HP:0000225)1.86843570
116Urticaria (HP:0001025)1.86671663
117Abnormality of the labia majora (HP:0012881)1.85752192
118Oculomotor apraxia (HP:0000657)1.85722803
119Elevated erythrocyte sedimentation rate (HP:0003565)1.85439190
120Global brain atrophy (HP:0002283)1.83864781
121Abnormality of the common coagulation pathway (HP:0010990)1.83776840
122Bone pain (HP:0002653)1.83181369
123Osteomyelitis (HP:0002754)1.82316717
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82079555
125Anophthalmia (HP:0000528)1.81836774
126Inflammation of the large intestine (HP:0002037)1.81495439
127Abnormality of the labia (HP:0000058)1.81361589
128Increased IgE level (HP:0003212)1.80934105
129Premature loss of primary teeth (HP:0006323)1.80436263
130Mitral valve prolapse (HP:0001634)1.80014443
131Furrowed tongue (HP:0000221)1.80000177
132Tubular atrophy (HP:0000092)1.79634052
133Disproportionate short-trunk short stature (HP:0003521)1.79161478
134Persistence of primary teeth (HP:0006335)1.78634409
135Renal cortical cysts (HP:0000803)1.77086529
136Abnormal biliary tract morphology (HP:0012440)1.75377297
137Protrusio acetabuli (HP:0003179)1.74428237
138Coarse hair (HP:0002208)1.73941920
139Fair hair (HP:0002286)1.73730797
140Arterial tortuosity (HP:0005116)1.72926293
141Dandy-Walker malformation (HP:0001305)1.72735246
142Basal ganglia calcification (HP:0002135)1.72345425
143Biliary tract neoplasm (HP:0100574)1.71502396
144Recurrent viral infections (HP:0004429)1.71342834
145Epidermoid cyst (HP:0200040)1.71132647
146Keratoconjunctivitis (HP:0001096)1.71074039
147Curly hair (HP:0002212)1.70974820
148Gastrointestinal inflammation (HP:0004386)1.70907263
149Spondylolisthesis (HP:0003302)1.70901605
150Narrow forehead (HP:0000341)1.70886508
151Arterial thrombosis (HP:0004420)1.70404617
152Methylmalonic acidemia (HP:0002912)1.70382567
153Preaxial hand polydactyly (HP:0001177)1.69689037
154Adenoma sebaceum (HP:0009720)1.69414313
155Angiofibromas (HP:0010615)1.69414313
156Vascular tortuosity (HP:0004948)1.68744720
157Dilatation of the ascending aorta (HP:0005111)1.68046896
158Spontaneous hematomas (HP:0007420)1.67670215
159Postaxial hand polydactyly (HP:0001162)1.67642233
160Joint hemorrhage (HP:0005261)1.67152184
161Neoplasm of striated muscle (HP:0009728)1.66431800
162Skin nodule (HP:0200036)1.65998131
163Abdominal distention (HP:0003270)1.64686909
164Atrophic scars (HP:0001075)1.64397136
165Retinal atrophy (HP:0001105)1.64124970
166Thoracic kyphosis (HP:0002942)1.64034680
167Obstructive lung disease (HP:0006536)1.63302156
168Chronic obstructive pulmonary disease (HP:0006510)1.63302156
169Widely spaced teeth (HP:0000687)1.63266625
170Emphysema (HP:0002097)1.62928705
171Neoplasm of the adrenal gland (HP:0100631)1.62798215
172Asymmetric septal hypertrophy (HP:0001670)1.62724580
173Tongue fasciculations (HP:0001308)1.61979758
174Rhabdomyosarcoma (HP:0002859)1.60184931
175Esophageal atresia (HP:0002032)1.58434499
176Nausea (HP:0002018)1.57885200
177Congenital stationary night blindness (HP:0007642)1.57847688
178Hypobetalipoproteinemia (HP:0003563)1.57697819
179Abnormality of vitamin metabolism (HP:0100508)1.56895077
180Abnormality of the vitamin B12 metabolism (HP:0004341)1.56097415
181Palmar hyperkeratosis (HP:0010765)1.55549643
182Cupped ear (HP:0000378)1.55425358
183Irregular vertebral endplates (HP:0003301)1.55230611
184Hypoplastic pelvis (HP:0008839)1.54299553
185Medulloblastoma (HP:0002885)1.53844525
186Erythroderma (HP:0001019)1.52886235
187Congenital sensorineural hearing impairment (HP:0008527)1.52822942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.47163948
2ERN13.29223007
3CASK3.20646751
4MAP3K143.20581411
5ACVR1B3.16938717
6MST43.12894337
7TRIB32.68174518
8TRIM282.62908495
9TBK12.57865530
10TYK22.53062443
11IRAK32.44745189
12TNIK2.38698650
13TGFBR22.38634099
14BMPR1B2.33772886
15MKNK22.23898173
16PTK62.07411783
17EIF2AK32.06965002
18EPHA32.00338170
19IRAK41.96943741
20TTN1.90946483
21KIT1.87797204
22MAP4K21.84625273
23RIPK11.83446935
24STK391.78527367
25CAMK1D1.78056227
26MAP3K101.77971214
27FGFR41.76461952
28EPHB11.76067338
29JAK11.74142939
30PBK1.71875984
31PKN21.68672590
32EPHB21.67469191
33JAK31.64383941
34BLK1.64223573
35PNCK1.59312338
36CHUK1.59155938
37IKBKB1.58933356
38SIK11.56696541
39PDGFRA1.55648957
40FGFR21.53793231
41SCYL21.52326731
42PAK31.47036164
43GRK11.45263980
44IKBKE1.43567097
45CDK121.43279425
46MAP3K31.41628388
47ADRBK21.40274347
48TGFBR11.40064483
49TAOK31.38854347
50MAP3K41.35958642
51CSF1R1.35498998
52CSNK1G11.35235889
53STK38L1.34046130
54NEK91.33140050
55BCR1.32860153
56MAP3K131.32704153
57PDK21.29659571
58STK101.29384069
59TSSK61.26526223
60PLK21.26198313
61EIF2AK11.24664474
62EPHA41.23950248
63LATS11.23912941
64DDR21.22975129
65PAK41.22732112
66FGFR31.20940071
67CSNK1G21.17972116
68PLK31.16172618
69ZAK1.15883700
70MAPK131.15419817
71RPS6KA41.14648721
72MAP3K121.14237979
73MKNK11.12741829
74LRRK21.11568086
75CSK1.11069964
76EPHA21.10358598
77FRK1.10246073
78YES11.10106541
79CDK61.09997393
80MAP4K11.06469788
81OXSR11.03066619
82STK31.02837083
83JAK21.00871599
84ITK1.00841412
85CSNK1G30.99684540
86MST1R0.98894743
87RIPK40.98815524
88PRKCE0.97540850
89BUB10.95726411
90HCK0.95269797
91MAP2K30.95259810
92FLT30.92810570
93BMX0.92647513
94WEE10.92524244
95EEF2K0.91795126
96BTK0.91103445
97CAMK1G0.90000629
98BRSK20.89376274
99PTK20.89149110
100ZAP700.88867130
101DYRK1B0.87388297
102STK240.85101925
103CSNK1A1L0.83872802
104MATK0.82347485
105PRKCI0.81119682
106TRPM70.80977918
107ERBB30.80183266
108PDGFRB0.76409358
109SIK30.76199153
110MAPK150.74474704
111MTOR0.71550055
112MAP2K20.71510874
113EGFR0.70386232
114TTK0.70296147
115PIM10.69831307
116FGFR10.69412400
117KSR10.67552216
118MUSK0.64963962
119PAK20.64208083
120INSRR0.63696084
121GSK3A0.63167145
122ABL10.60920465
123FGR0.59893104
124NUAK10.59862787
125MAP3K20.58410937
126PIM20.58397341
127PRKCG0.57339029
128LCK0.57187714
129GRK70.56876802
130ROCK10.56172984
131IRAK10.55860520
132PLK10.54739046
133LYN0.54454033
134MOS0.53253209
135MARK30.53135687
136NLK0.52867067
137EIF2AK20.52572064
138SYK0.51562513
139LMTK20.50355427
140ATM0.48496703
141CDK90.48220812
142MET0.48128210
143MAPKAPK20.47593571
144GRK60.47325365
145MELK0.47139798
146ERBB40.46213929
147CAMK2D0.45172821
148SIK20.44914414
149ERBB20.44811588
150MARK10.44571406
151PRKAA20.44042447
152PRKD30.42923215
153VRK10.41828580
154TESK10.41521863
155PRKG20.41153629
156DYRK20.41141133
157TAF10.40881699
158NEK10.40120065
159INSR0.39588166
160BRD40.39061918
161IGF1R0.38985602
162FER0.38917819
163MAP3K80.38902086
164TEC0.38682128
165PLK40.38312838
166CSNK1D0.38226992
167ROCK20.37816695
168PIK3CG0.37593670
169MAP2K70.37072582
170WNK40.36886438
171CSNK1A10.35861609
172AKT30.35441133
173CCNB10.35430348
174SRPK10.34820366
175PHKG10.32937722
176PHKG20.32937722

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.12082143
2Staphylococcus aureus infection_Homo sapiens_hsa051503.07575484
3Steroid biosynthesis_Homo sapiens_hsa001003.02376719
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.96441259
5Lysosome_Homo sapiens_hsa041422.88867659
6Protein export_Homo sapiens_hsa030602.55739770
7Sulfur metabolism_Homo sapiens_hsa009202.43637456
8Leishmaniasis_Homo sapiens_hsa051402.41491288
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36412833
10Fatty acid elongation_Homo sapiens_hsa000622.34169241
11Propanoate metabolism_Homo sapiens_hsa006402.23719127
12Proteasome_Homo sapiens_hsa030502.19196921
13Caffeine metabolism_Homo sapiens_hsa002322.12729937
14Non-homologous end-joining_Homo sapiens_hsa034502.12403953
15Other glycan degradation_Homo sapiens_hsa005112.10835226
16Osteoclast differentiation_Homo sapiens_hsa043802.07071491
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01617086
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99025705
19Butanoate metabolism_Homo sapiens_hsa006501.98997522
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96823594
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.90324944
22Legionellosis_Homo sapiens_hsa051341.79970910
23Antigen processing and presentation_Homo sapiens_hsa046121.75110854
24Tuberculosis_Homo sapiens_hsa051521.73543404
25Pertussis_Homo sapiens_hsa051331.68128478
26Complement and coagulation cascades_Homo sapiens_hsa046101.66837116
27Toxoplasmosis_Homo sapiens_hsa051451.53236627
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52206126
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51464597
30Chemical carcinogenesis_Homo sapiens_hsa052041.49000838
31beta-Alanine metabolism_Homo sapiens_hsa004101.48011302
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45121727
33Malaria_Homo sapiens_hsa051441.44233382
34Vitamin B6 metabolism_Homo sapiens_hsa007501.44152801
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41055326
36Glutathione metabolism_Homo sapiens_hsa004801.41023791
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40784844
38Ether lipid metabolism_Homo sapiens_hsa005651.39725912
39Linoleic acid metabolism_Homo sapiens_hsa005911.37909721
40Peroxisome_Homo sapiens_hsa041461.37586308
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36481415
42TNF signaling pathway_Homo sapiens_hsa046681.35626623
43Apoptosis_Homo sapiens_hsa042101.34232537
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33751607
45Phagosome_Homo sapiens_hsa041451.32346516
46Retinol metabolism_Homo sapiens_hsa008301.30295884
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30169543
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29304149
49Fatty acid metabolism_Homo sapiens_hsa012121.25819558
50Measles_Homo sapiens_hsa051621.23560105
51B cell receptor signaling pathway_Homo sapiens_hsa046621.20858235
52Basal transcription factors_Homo sapiens_hsa030221.20617035
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.18455864
54Collecting duct acid secretion_Homo sapiens_hsa049661.17838064
55Fanconi anemia pathway_Homo sapiens_hsa034601.17703787
56Chronic myeloid leukemia_Homo sapiens_hsa052201.17442834
57Histidine metabolism_Homo sapiens_hsa003401.15324832
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.13955282
59Influenza A_Homo sapiens_hsa051641.12825702
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11275574
61Amoebiasis_Homo sapiens_hsa051461.09503210
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08053398
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07884015
64Small cell lung cancer_Homo sapiens_hsa052221.05916035
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04120577
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03438694
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.98339240
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.98122350
69ABC transporters_Homo sapiens_hsa020100.94800665
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94790397
71Pancreatic cancer_Homo sapiens_hsa052120.94245692
72Tight junction_Homo sapiens_hsa045300.94003729
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92605175
74Starch and sucrose metabolism_Homo sapiens_hsa005000.92296036
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91796825
76TGF-beta signaling pathway_Homo sapiens_hsa043500.90290216
77Hepatitis B_Homo sapiens_hsa051610.89107663
78Shigellosis_Homo sapiens_hsa051310.88618413
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88560086
80Salmonella infection_Homo sapiens_hsa051320.88460602
81Rheumatoid arthritis_Homo sapiens_hsa053230.88423580
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88111665
83PPAR signaling pathway_Homo sapiens_hsa033200.87793943
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87730377
85Fat digestion and absorption_Homo sapiens_hsa049750.87581199
86Phototransduction_Homo sapiens_hsa047440.84791501
87Proteoglycans in cancer_Homo sapiens_hsa052050.84042795
88Hepatitis C_Homo sapiens_hsa051600.83315945
89Herpes simplex infection_Homo sapiens_hsa051680.83029963
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82276665
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.82219380
92Nitrogen metabolism_Homo sapiens_hsa009100.81986728
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81770053
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.80865340
95Insulin resistance_Homo sapiens_hsa049310.79982045
96Chemokine signaling pathway_Homo sapiens_hsa040620.78722781
97Adherens junction_Homo sapiens_hsa045200.78223937
98Selenocompound metabolism_Homo sapiens_hsa004500.77738134
99Renin-angiotensin system_Homo sapiens_hsa046140.77235100
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.73478195
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72442294
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71986134
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.70061904
104Prion diseases_Homo sapiens_hsa050200.69691912
105Hematopoietic cell lineage_Homo sapiens_hsa046400.69028933
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68583584
107Acute myeloid leukemia_Homo sapiens_hsa052210.68053800
108Graft-versus-host disease_Homo sapiens_hsa053320.67499467
109Hippo signaling pathway_Homo sapiens_hsa043900.67487216
110Arginine biosynthesis_Homo sapiens_hsa002200.67062047
111Tryptophan metabolism_Homo sapiens_hsa003800.66485202
112Focal adhesion_Homo sapiens_hsa045100.65668276
113Folate biosynthesis_Homo sapiens_hsa007900.64656183
114Viral myocarditis_Homo sapiens_hsa054160.63586272
115MicroRNAs in cancer_Homo sapiens_hsa052060.63286648
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62444657
117Homologous recombination_Homo sapiens_hsa034400.61937675
118Pyruvate metabolism_Homo sapiens_hsa006200.61480671
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.61474352
120Notch signaling pathway_Homo sapiens_hsa043300.61058141
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60796320
122ECM-receptor interaction_Homo sapiens_hsa045120.60743939
123Allograft rejection_Homo sapiens_hsa053300.60308046
124Vitamin digestion and absorption_Homo sapiens_hsa049770.60057036
125Prolactin signaling pathway_Homo sapiens_hsa049170.57028991
126Arachidonic acid metabolism_Homo sapiens_hsa005900.56265441
127N-Glycan biosynthesis_Homo sapiens_hsa005100.55236081
128Hedgehog signaling pathway_Homo sapiens_hsa043400.55172852
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.55110547
130Bladder cancer_Homo sapiens_hsa052190.54855336
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54131667
132Galactose metabolism_Homo sapiens_hsa000520.53950557
133Viral carcinogenesis_Homo sapiens_hsa052030.53836875
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53584636
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52857176
136Fatty acid degradation_Homo sapiens_hsa000710.52636873
137* Metabolic pathways_Homo sapiens_hsa011000.51982209
138Mineral absorption_Homo sapiens_hsa049780.51764817
139Basal cell carcinoma_Homo sapiens_hsa052170.51691293
140Asthma_Homo sapiens_hsa053100.51640009
141Lysine degradation_Homo sapiens_hsa003100.50755370
142Glycerolipid metabolism_Homo sapiens_hsa005610.50091195
143Type II diabetes mellitus_Homo sapiens_hsa049300.49918259
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49716676
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49707483
146Bile secretion_Homo sapiens_hsa049760.48215530
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46861624
148p53 signaling pathway_Homo sapiens_hsa041150.46534515
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45986194
150* Sphingolipid metabolism_Homo sapiens_hsa006000.45510806
151Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45480477
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44566871
153Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44223338
154Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43166909
155Vibrio cholerae infection_Homo sapiens_hsa051100.42896998
156Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41662370
1572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41444005
158Arginine and proline metabolism_Homo sapiens_hsa003300.40457497
159Dorso-ventral axis formation_Homo sapiens_hsa043200.39489889
160Regulation of autophagy_Homo sapiens_hsa041400.38789971
161Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36039589
162Cyanoamino acid metabolism_Homo sapiens_hsa004600.35763165
163Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34703724
164Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32876840
165Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23370994

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