SGK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.89922569
2tryptophan catabolic process (GO:0006569)4.50682358
3indole-containing compound catabolic process (GO:0042436)4.50682358
4indolalkylamine catabolic process (GO:0046218)4.50682358
5cellular response to exogenous dsRNA (GO:0071360)4.34334617
6response to peptidoglycan (GO:0032494)4.17740706
7regulation of B cell receptor signaling pathway (GO:0050855)4.16038599
8neutrophil activation involved in immune response (GO:0002283)4.13116070
9positive regulation by symbiont of host defense response (GO:0052509)4.03588380
10modulation by symbiont of host defense response (GO:0052031)4.03588380
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.03588380
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.03588380
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.03588380
14modulation by symbiont of host immune response (GO:0052553)4.03588380
15kynurenine metabolic process (GO:0070189)4.03309261
16regulation of interferon-beta biosynthetic process (GO:0045357)4.01067311
17production of molecular mediator involved in inflammatory response (GO:0002532)3.95586478
18tryptophan metabolic process (GO:0006568)3.90572431
19immunoglobulin mediated immune response (GO:0016064)3.89958992
20indolalkylamine metabolic process (GO:0006586)3.84021968
21antigen processing and presentation of endogenous antigen (GO:0019883)3.67395568
22superoxide anion generation (GO:0042554)3.65775023
23positive regulation of antigen processing and presentation (GO:0002579)3.59421112
24respiratory burst (GO:0045730)3.56509862
25macrophage activation involved in immune response (GO:0002281)3.49158902
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48207881
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.48207881
28neutrophil mediated immunity (GO:0002446)3.42235486
29positive regulation of gamma-delta T cell activation (GO:0046645)3.37402766
30mast cell activation (GO:0045576)3.37214057
31positive regulation of interferon-alpha production (GO:0032727)3.36422500
32positive regulation of B cell differentiation (GO:0045579)3.27741370
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.26547340
34cellular response to type I interferon (GO:0071357)3.26267491
35type I interferon signaling pathway (GO:0060337)3.26267491
36positive regulation of interferon-beta production (GO:0032728)3.24168640
37defense response to protozoan (GO:0042832)3.23918054
38response to type I interferon (GO:0034340)3.23165945
39neutrophil activation (GO:0042119)3.20975720
40myeloid cell activation involved in immune response (GO:0002275)3.17581181
41response to pheromone (GO:0019236)3.16910480
42regulation of B cell differentiation (GO:0045577)3.16858471
43regulation of interferon-alpha production (GO:0032647)3.15876582
44fucose catabolic process (GO:0019317)3.15701752
45L-fucose metabolic process (GO:0042354)3.15701752
46L-fucose catabolic process (GO:0042355)3.15701752
47regulation of MHC class II biosynthetic process (GO:0045346)3.13381321
48detection of other organism (GO:0098543)3.13063660
49regulation of antigen processing and presentation (GO:0002577)3.11624249
50regulation of RIG-I signaling pathway (GO:0039535)3.09437187
51interferon-gamma-mediated signaling pathway (GO:0060333)3.08308838
52DNA deamination (GO:0045006)3.07698382
53positive regulation of defense response to virus by host (GO:0002230)3.07157269
54B cell mediated immunity (GO:0019724)3.06579117
55pinocytosis (GO:0006907)3.05934360
56regulation of chemokine biosynthetic process (GO:0045073)3.05265292
57regulation of mast cell activation (GO:0033003)3.04905133
58behavioral response to nicotine (GO:0035095)3.02413607
59cellular response to interferon-beta (GO:0035458)3.02218471
60regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00964899
61granulocyte activation (GO:0036230)2.99479173
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98076912
63response to host immune response (GO:0052572)2.98076912
64regulation of mast cell degranulation (GO:0043304)2.96259524
65platelet dense granule organization (GO:0060155)2.95167677
66response to protozoan (GO:0001562)2.92171356
67microglial cell activation (GO:0001774)2.92048198
68negative regulation of interleukin-12 production (GO:0032695)2.90929009
69response to interferon-beta (GO:0035456)2.89357246
70cellular biogenic amine catabolic process (GO:0042402)2.86941830
71amine catabolic process (GO:0009310)2.86941830
72regulation of memory T cell differentiation (GO:0043380)2.86554946
73negative regulation of mast cell activation (GO:0033004)2.86130782
74positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.84196130
75myeloid dendritic cell activation (GO:0001773)2.84020772
76positive regulation of T cell migration (GO:2000406)2.83225950
77macrophage activation (GO:0042116)2.81968813
78positive regulation of mast cell activation (GO:0033005)2.80749828
79response to interferon-alpha (GO:0035455)2.79688817
80leukocyte mediated cytotoxicity (GO:0001909)2.79121149
81water-soluble vitamin biosynthetic process (GO:0042364)2.77587416
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76733302
83detection of bacterium (GO:0016045)2.75892150
84G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.75761864
85indole-containing compound metabolic process (GO:0042430)2.74884758
86cellular extravasation (GO:0045123)2.74643718
87natural killer cell mediated cytotoxicity (GO:0042267)2.74308440
88natural killer cell mediated immunity (GO:0002228)2.74308440
89positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73698408
90positive regulation of mast cell degranulation (GO:0043306)2.71936164
91positive regulation of mast cell activation involved in immune response (GO:0033008)2.71936164
92regulation of mast cell activation involved in immune response (GO:0033006)2.71747125
93protein K11-linked deubiquitination (GO:0035871)2.71082047
94leukocyte aggregation (GO:0070486)2.70378829
95dendritic cell migration (GO:0036336)2.69434082
96myeloid leukocyte activation (GO:0002274)2.69135994
97dendritic cell chemotaxis (GO:0002407)2.68823427
98myeloid leukocyte mediated immunity (GO:0002444)2.67627308
99negative regulation of phagocytosis (GO:0050765)2.67202722
100response to muramyl dipeptide (GO:0032495)2.66622834
101lipoxygenase pathway (GO:0019372)2.66164416
102leukocyte degranulation (GO:0043299)2.65857170
103germinal center formation (GO:0002467)2.65542027
104positive regulation of chemokine biosynthetic process (GO:0045080)2.64632774
105regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.63664509
106aromatic amino acid family catabolic process (GO:0009074)2.63156885
107regulation of gamma-delta T cell activation (GO:0046643)2.62556937
108interferon-gamma production (GO:0032609)2.62550378
109lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62428933
110regulation of T cell migration (GO:2000404)2.61726610
111negative regulation of growth of symbiont in host (GO:0044130)2.61330016
112negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.61330016
113modulation of growth of symbiont involved in interaction with host (GO:0044144)2.61330016
114regulation of growth of symbiont in host (GO:0044126)2.61330016
115T cell migration (GO:0072678)2.60564526
116negative regulation of interleukin-1 beta production (GO:0032691)2.59890494
117negative regulation of viral genome replication (GO:0045071)2.58791667
118I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.58787831
119positive regulation of interleukin-12 production (GO:0032735)2.57573118
120meiotic chromosome segregation (GO:0045132)2.57565043
121positive regulation of cellular amide metabolic process (GO:0034250)2.57532093
122cellular ketone body metabolic process (GO:0046950)2.56906256
123negative regulation of myeloid cell apoptotic process (GO:0033033)2.56319764
124NIK/NF-kappaB signaling (GO:0038061)2.56196790
125B cell receptor signaling pathway (GO:0050853)2.55922023
126NAD biosynthetic process (GO:0009435)2.55898866
127positive regulation of lymphocyte migration (GO:2000403)2.55658768
128regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.55510376
129positive regulation of T-helper 1 type immune response (GO:0002827)2.53968314
130response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.53496931
131response to host defenses (GO:0052200)2.53496931
132positive regulation of prostaglandin secretion (GO:0032308)2.51940779
133detection of light stimulus involved in visual perception (GO:0050908)2.49730378
134detection of light stimulus involved in sensory perception (GO:0050962)2.49730378
135positive regulation of toll-like receptor signaling pathway (GO:0034123)2.49643535
136positive regulation of fatty acid transport (GO:2000193)2.48180820
137detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.47916198
138piRNA metabolic process (GO:0034587)2.44586524
139adaptation of signaling pathway (GO:0023058)2.44584019
140negative regulation of interleukin-1 production (GO:0032692)2.40685790
141ketone body metabolic process (GO:1902224)2.40090040
142neural tube formation (GO:0001841)2.39480747
143cellular response to ethanol (GO:0071361)2.38538077
144benzene-containing compound metabolic process (GO:0042537)2.38459168
145regulation of interleukin-12 production (GO:0032655)2.37698524
146axoneme assembly (GO:0035082)2.36241727
147hydrogen peroxide biosynthetic process (GO:0050665)2.36026638
148positive regulation of oligodendrocyte differentiation (GO:0048714)2.35325217
149negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.34648559
150positive regulation of interleukin-1 beta secretion (GO:0050718)2.34311083
151reactive oxygen species biosynthetic process (GO:1903409)2.34015287
152cellular response to ATP (GO:0071318)2.31131443
153activated T cell proliferation (GO:0050798)2.30752099
154phosphatidylinositol acyl-chain remodeling (GO:0036149)2.30285658
155regulation of interleukin-12 biosynthetic process (GO:0045075)2.29731431
156epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.29217654
157regulation of interleukin-6 biosynthetic process (GO:0045408)2.25629758
158regulation of regulatory T cell differentiation (GO:0045589)2.25007861
159positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.24858885
160response to xenobiotic stimulus (GO:0009410)2.24821434
161oligosaccharide catabolic process (GO:0009313)2.24102976
162cytokine biosynthetic process (GO:0042089)2.22923041
163signal peptide processing (GO:0006465)2.22137328
164regulation of interleukin-1 beta secretion (GO:0050706)2.21096304
165regulation of gamma-delta T cell differentiation (GO:0045586)2.21055559
166regulation of T cell mediated cytotoxicity (GO:0001914)2.20982641
167cell wall macromolecule metabolic process (GO:0044036)2.20400258
168negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.20119040
169regulation of prostaglandin secretion (GO:0032306)2.19572788
170positive regulation of interleukin-1 secretion (GO:0050716)2.19539887
171positive regulation of icosanoid secretion (GO:0032305)2.18128485
172cell wall macromolecule catabolic process (GO:0016998)2.17908029
173negative regulation of T cell mediated immunity (GO:0002710)2.17565013
174positive regulation of cAMP-mediated signaling (GO:0043950)2.16361760
175regulation of germinal center formation (GO:0002634)2.16277069
176preassembly of GPI anchor in ER membrane (GO:0016254)2.16022473
177regulation of T-helper 1 type immune response (GO:0002825)2.15437793

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.45194760
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.30326880
3E2F7_22180533_ChIP-Seq_HELA_Human5.00789703
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.24537493
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.08870875
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.37795306
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.20480556
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10083190
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08750787
10GATA1_22025678_ChIP-Seq_K562_Human2.93448506
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.91808376
12SCL_19346495_ChIP-Seq_HPC-7_Human2.78511131
13ZNF274_21170338_ChIP-Seq_K562_Hela2.76194146
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70533053
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60213528
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58207100
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.54585341
18VDR_22108803_ChIP-Seq_LS180_Human2.47524416
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46654376
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.39880462
21SPI1_23547873_ChIP-Seq_NB4_Human2.38242538
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.38240914
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34866383
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.33640371
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28661924
26IGF1R_20145208_ChIP-Seq_DFB_Human2.27861435
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13692723
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11316175
29GBX2_23144817_ChIP-Seq_PC3_Human2.08538918
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07374231
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.02340101
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96639830
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.92820153
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90297836
35ER_23166858_ChIP-Seq_MCF-7_Human1.89510671
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.86591081
37MYB_26560356_Chip-Seq_TH2_Human1.79561681
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78546441
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76514954
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73490886
41* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70833408
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65116313
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65108687
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.64271425
45P300_19829295_ChIP-Seq_ESCs_Human1.62452242
46* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62105485
47TAF15_26573619_Chip-Seq_HEK293_Human1.61305293
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61292436
49* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60989946
50* PU_27001747_Chip-Seq_BMDM_Mouse1.56694718
51* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56186061
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55559556
53* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55427898
54MYB_26560356_Chip-Seq_TH1_Human1.53493585
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.50956254
56VDR_24787735_ChIP-Seq_THP-1_Human1.50612692
57BCAT_22108803_ChIP-Seq_LS180_Human1.50281334
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50251780
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50192809
60* FLI1_27457419_Chip-Seq_LIVER_Mouse1.49335864
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.48672994
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48581176
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48244296
64* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46451990
65EWS_26573619_Chip-Seq_HEK293_Human1.46030975
66* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45756903
67RUNX_20019798_ChIP-Seq_JUKART_Human1.45496027
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40232285
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40143740
70* STAT3_23295773_ChIP-Seq_U87_Human1.39276443
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38771026
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36805134
73* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36363447
74FUS_26573619_Chip-Seq_HEK293_Human1.35517829
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34791778
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33241955
77TCF4_23295773_ChIP-Seq_U87_Human1.32601020
78* NFE2_27457419_Chip-Seq_LIVER_Mouse1.31277386
79CBP_20019798_ChIP-Seq_JUKART_Human1.31206735
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31206735
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30012550
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29844361
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27317181
84VDR_23849224_ChIP-Seq_CD4+_Human1.27266500
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27101013
86VDR_24763502_ChIP-Seq_THP-1_Human1.26058242
87TP53_22573176_ChIP-Seq_HFKS_Human1.25961737
88NANOG_19829295_ChIP-Seq_ESCs_Human1.25632113
89SOX2_19829295_ChIP-Seq_ESCs_Human1.25632113
90AR_25329375_ChIP-Seq_VCAP_Human1.25120825
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24498068
92GABP_17652178_ChIP-ChIP_JURKAT_Human1.24388957
93* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23943197
94* PIAS1_25552417_ChIP-Seq_VCAP_Human1.22913485
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22007134
96* SMAD4_21799915_ChIP-Seq_A2780_Human1.21604861
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.21266915
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21130267
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20403133
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20210629
101FOXA1_25329375_ChIP-Seq_VCAP_Human1.19863190
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19863190
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19711900
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19711900
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.19608077
106* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19543676
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19144807
108GATA3_26560356_Chip-Seq_TH2_Human1.19138310
109TCF4_22108803_ChIP-Seq_LS180_Human1.18832534
110* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18503576
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15936345
112* CRX_20693478_ChIP-Seq_RETINA_Mouse1.15935770
113* EZH2_27294783_Chip-Seq_NPCs_Mouse1.15705865
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15667661
115GATA3_21878914_ChIP-Seq_MCF-7_Human1.15217724
116ELK1_19687146_ChIP-ChIP_HELA_Human1.14706916
117* CDX2_22108803_ChIP-Seq_LS180_Human1.14595553
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14388644
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14062417
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12754889
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12532685
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11841641
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11027974
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10904013
125AR_20517297_ChIP-Seq_VCAP_Human1.10867013
126SMRT_27268052_Chip-Seq_Bcells_Human1.10366975
127E2F1_21310950_ChIP-Seq_MCF-7_Human1.09564962
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09383602
129SRF_21415370_ChIP-Seq_HL-1_Mouse1.09164514
130MAF_26560356_Chip-Seq_TH1_Human1.09135802
131ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08507652
132IRF1_19129219_ChIP-ChIP_H3396_Human1.07613019
133* SPI1_23127762_ChIP-Seq_K562_Human1.07515310
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07335015
135* P53_22387025_ChIP-Seq_ESCs_Mouse1.06458834
136* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05416250
137PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05325568
138* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04816745
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04398644
140* NANOG_18555785_Chip-Seq_ESCs_Mouse1.04349213
141GATA3_27048872_Chip-Seq_THYMUS_Human1.03498159
142* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02414826
143RUNX2_22187159_ChIP-Seq_PCA_Human1.01813163
144SMAD3_21741376_ChIP-Seq_EPCs_Human1.01416267
145OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00626964
146TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00168242
147GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99939198
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.99930186
149VDR_21846776_ChIP-Seq_THP-1_Human0.99380183
150KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98284691
151E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97385285
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96967136
153CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96682776
154EST1_17652178_ChIP-ChIP_JURKAT_Human0.95667445
155* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95367091
156TP63_19390658_ChIP-ChIP_HaCaT_Human0.94802184
157FOXP3_21729870_ChIP-Seq_TREG_Human0.94425497
158GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93625967
159EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90635528
160* STAT3_18555785_Chip-Seq_ESCs_Mouse0.89671679
161* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87162628
162SMAD_19615063_ChIP-ChIP_OVARY_Human0.86677196
163* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86362322
164JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86201679
165* NMYC_18555785_Chip-Seq_ESCs_Mouse0.84323587
166GATA2_21666600_ChIP-Seq_HMVEC_Human0.82940223
167RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82633460
168* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.81915283
169PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81009684
170PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80465588
171GATA1_19941827_ChIP-Seq_MEL_Mouse0.78934831
172* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.78929973

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.77639280
2MP0003195_calcinosis3.36902049
3MP0009785_altered_susceptibility_to3.17296348
4MP0002148_abnormal_hypersensitivity_rea2.94928613
5MP0002419_abnormal_innate_immunity2.84367889
6MP0003436_decreased_susceptibility_to2.73321878
7MP0002396_abnormal_hematopoietic_system2.72682554
8MP0005025_abnormal_response_to2.63676292
9MP0005671_abnormal_response_to2.61010414
10MP0005000_abnormal_immune_tolerance2.60587924
11MP0001790_abnormal_immune_system2.48500737
12MP0005387_immune_system_phenotype2.48500737
13MP0002452_abnormal_antigen_presenting2.47961655
14MP0001800_abnormal_humoral_immune2.47475512
15MP0000685_abnormal_immune_system2.45014936
16MP0002723_abnormal_immune_serum2.34565014
17MP0001819_abnormal_immune_cell2.25277258
18MP0002420_abnormal_adaptive_immunity2.23822362
19MP0003724_increased_susceptibility_to2.23359574
20MP0006082_CNS_inflammation2.13827530
21MP0005464_abnormal_platelet_physiology2.09167209
22MP0008057_abnormal_DNA_replication2.02265780
23MP0008875_abnormal_xenobiotic_pharmacok1.94749153
24MP0003693_abnormal_embryo_hatching1.94453217
25MP0005397_hematopoietic_system_phenotyp1.89219732
26MP0001545_abnormal_hematopoietic_system1.89219732
27MP0001853_heart_inflammation1.87086497
28MP0002398_abnormal_bone_marrow1.84383303
29MP0000716_abnormal_immune_system1.79307911
30MP0002166_altered_tumor_susceptibility1.77779384
31MP0009333_abnormal_splenocyte_physiolog1.75618456
32MP0004808_abnormal_hematopoietic_stem1.71957448
33MP0002405_respiratory_system_inflammati1.71197966
34MP0002006_tumorigenesis1.70797873
35MP0005174_abnormal_tail_pigmentation1.69752416
36MP0010094_abnormal_chromosome_stability1.69210365
37MP0002876_abnormal_thyroid_physiology1.68333884
38MP0001501_abnormal_sleep_pattern1.66981658
39MP0005646_abnormal_pituitary_gland1.65264964
40MP0005551_abnormal_eye_electrophysiolog1.65234941
41MP0003646_muscle_fatigue1.64459535
42MP0002837_dystrophic_cardiac_calcinosis1.63430178
43MP0008058_abnormal_DNA_repair1.62179291
44MP0003303_peritoneal_inflammation1.60857556
45MP0000015_abnormal_ear_pigmentation1.60613047
46MP0003787_abnormal_imprinting1.59260770
47MP0000689_abnormal_spleen_morphology1.58008167
48* MP0001845_abnormal_inflammatory_respons1.57208539
49MP0003011_delayed_dark_adaptation1.53697247
50MP0005075_abnormal_melanosome_morpholog1.52665500
51MP0000465_gastrointestinal_hemorrhage1.51212193
52MP0004043_abnormal_pH_regulation1.51135967
53MP0002429_abnormal_blood_cell1.50542484
54MP0005310_abnormal_salivary_gland1.49058866
55MP0002722_abnormal_immune_system1.47255309
56MP0003763_abnormal_thymus_physiology1.46829096
57MP0005167_abnormal_blood-brain_barrier1.46347151
58MP0010155_abnormal_intestine_physiology1.45990568
59MP0005379_endocrine/exocrine_gland_phen1.44989857
60MP0002095_abnormal_skin_pigmentation1.43771833
61MP0008260_abnormal_autophagy1.42653839
62MP0009764_decreased_sensitivity_to1.42217553
63MP0005058_abnormal_lysosome_morphology1.40059878
64MP0008469_abnormal_protein_level1.36401120
65MP0002139_abnormal_hepatobiliary_system1.36371681
66MP0001533_abnormal_skeleton_physiology1.36073051
67MP0009278_abnormal_bone_marrow1.31245804
68MP0010386_abnormal_urinary_bladder1.30665776
69MP0003448_altered_tumor_morphology1.28502089
70MP0003111_abnormal_nucleus_morphology1.28450419
71MP0002277_abnormal_respiratory_mucosa1.25814386
72MP0002693_abnormal_pancreas_physiology1.24621431
73MP0004381_abnormal_hair_follicle1.23833767
74MP0001873_stomach_inflammation1.21896967
75MP0004947_skin_inflammation1.21586549
76MP0000569_abnormal_digit_pigmentation1.20452567
77MP0009046_muscle_twitch1.19797833
78MP0002254_reproductive_system_inflammat1.18851593
79MP0003183_abnormal_peptide_metabolism1.18292331
80MP0008007_abnormal_cellular_replicative1.15629333
81MP0004510_myositis1.15529200
82MP0004147_increased_porphyrin_level1.14603494
83MP0000490_abnormal_crypts_of1.14423782
84MP0005253_abnormal_eye_physiology1.12324980
85MP0004782_abnormal_surfactant_physiolog1.11644297
86MP0000343_altered_response_to1.11397978
87MP0003786_premature_aging1.11276266
88MP0002132_abnormal_respiratory_system1.11105050
89MP0005365_abnormal_bile_salt1.10990305
90MP0003077_abnormal_cell_cycle1.10724948
91MP0000604_amyloidosis1.10519639
92MP0001968_abnormal_touch/_nociception1.08768619
93MP0004885_abnormal_endolymph1.07852480
94MP0002638_abnormal_pupillary_reflex1.06084994
95MP0000858_altered_metastatic_potential1.05740191
96MP0001986_abnormal_taste_sensitivity1.03926370
97MP0008877_abnormal_DNA_methylation1.03238183
98MP0009745_abnormal_behavioral_response1.02699615
99MP0003191_abnormal_cellular_cholesterol1.02400566
100MP0003252_abnormal_bile_duct1.01757846
101MP0000371_diluted_coat_color0.99802692
102MP0008872_abnormal_physiological_respon0.99629315
103MP0010329_abnormal_lipoprotein_level0.99335660
104MP0003172_abnormal_lysosome_physiology0.97775219
105MP0009840_abnormal_foam_cell0.97142374
106MP0002138_abnormal_hepatobiliary_system0.97049138
107MP0000703_abnormal_thymus_morphology0.95607530
108MP0002933_joint_inflammation0.95518236
109MP0005451_abnormal_body_composition0.95485469
110MP0002102_abnormal_ear_morphology0.95313085
111MP0003806_abnormal_nucleotide_metabolis0.95248684
112MP0005084_abnormal_gallbladder_morpholo0.93816628
113MP0008995_early_reproductive_senescence0.93232913
114MP0010307_abnormal_tumor_latency0.92929621
115MP0005085_abnormal_gallbladder_physiolo0.90477828
116MP0001919_abnormal_reproductive_system0.89472506
117MP0002019_abnormal_tumor_incidence0.88095976
118MP0005409_darkened_coat_color0.87767683
119MP0003633_abnormal_nervous_system0.87608496
120MP0002009_preneoplasia0.87530419
121MP0002998_abnormal_bone_remodeling0.87277276
122MP0002229_neurodegeneration0.86602934
123MP0003690_abnormal_glial_cell0.86432876
124MP0001324_abnormal_eye_pigmentation0.86329684
125MP0009697_abnormal_copulation0.85786471
126MP0004142_abnormal_muscle_tone0.85278618
127MP0006072_abnormal_retinal_apoptosis0.85090671
128MP0004130_abnormal_muscle_cell0.84942438
129MP0004742_abnormal_vestibular_system0.83672614
130MP0005645_abnormal_hypothalamus_physiol0.83515075
131MP0003186_abnormal_redox_activity0.82894953
132MP0003828_pulmonary_edema0.81981396
133MP0003045_fibrosis0.81187463
134MP0000230_abnormal_systemic_arterial0.80988963
135MP0002928_abnormal_bile_duct0.80388060
136MP0001764_abnormal_homeostasis0.79685073
137MP0005332_abnormal_amino_acid0.78745874
138MP0005389_reproductive_system_phenotype0.78663109
139MP0002064_seizures0.78616107
140* MP0000427_abnormal_hair_cycle0.78583121
141MP0009763_increased_sensitivity_to0.77719322
142MP0005410_abnormal_fertilization0.77369964
143MP0000372_irregular_coat_pigmentation0.77233603
144MP0003656_abnormal_erythrocyte_physiolo0.76486819
145MP0002653_abnormal_ependyma_morphology0.75628599
146MP0003136_yellow_coat_color0.73685311
147MP0005390_skeleton_phenotype0.73567447
148MP0006292_abnormal_olfactory_placode0.73477635
149MP0001188_hyperpigmentation0.72917041
150MP0002075_abnormal_coat/hair_pigmentati0.70779134
151MP0001186_pigmentation_phenotype0.67587543

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.40428088
2Recurrent bacterial skin infections (HP:0005406)5.06341851
3Eczematoid dermatitis (HP:0000976)4.49368995
4Myositis (HP:0100614)4.17510346
5Chromsome breakage (HP:0040012)4.09447103
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.07539295
7Abnormality of glycolipid metabolism (HP:0010969)3.83515480
8Abnormality of liposaccharide metabolism (HP:0010968)3.83515480
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.83515480
10Chronic mucocutaneous candidiasis (HP:0002728)3.82465470
11Recurrent cutaneous fungal infections (HP:0011370)3.82465470
12Recurrent skin infections (HP:0001581)3.80049876
13Recurrent fungal infections (HP:0002841)3.72690589
14Recurrent viral infections (HP:0004429)3.66061260
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.64882495
16Elevated erythrocyte sedimentation rate (HP:0003565)3.63026022
17Pancreatic cysts (HP:0001737)3.57917521
18Obstructive lung disease (HP:0006536)3.51998435
19Chronic obstructive pulmonary disease (HP:0006510)3.51998435
20Congenital stationary night blindness (HP:0007642)3.40509327
21Retrobulbar optic neuritis (HP:0100654)3.38046892
22Optic neuritis (HP:0100653)3.38046892
23Recurrent gram-negative bacterial infections (HP:0005420)3.37409128
24Abnormality of macrophages (HP:0004311)3.33177099
25Mediastinal lymphadenopathy (HP:0100721)3.26315239
26Pancreatic fibrosis (HP:0100732)3.22475213
27Molar tooth sign on MRI (HP:0002419)3.20601988
28Abnormality of midbrain morphology (HP:0002418)3.20601988
29Orchitis (HP:0100796)3.17117492
30Meningitis (HP:0001287)3.09625713
31Prostate neoplasm (HP:0100787)3.08053197
32Chronic otitis media (HP:0000389)3.04467587
33Panhypogammaglobulinemia (HP:0003139)3.02234895
34IgM deficiency (HP:0002850)3.02193109
35Abnormality of the renal cortex (HP:0011035)2.99429347
36True hermaphroditism (HP:0010459)2.95841903
37Pustule (HP:0200039)2.92950179
38Agammaglobulinemia (HP:0004432)2.89834628
39Abolished electroretinogram (ERG) (HP:0000550)2.88551648
40Attenuation of retinal blood vessels (HP:0007843)2.85725695
41Nephronophthisis (HP:0000090)2.82251659
42Abnormality of T cell physiology (HP:0011840)2.82071939
43Petechiae (HP:0000967)2.81654450
44Encephalitis (HP:0002383)2.81058161
45Type 2 muscle fiber atrophy (HP:0003554)2.77498434
46Gingivitis (HP:0000230)2.77312418
47Recurrent pneumonia (HP:0006532)2.74458108
48Vacuolated lymphocytes (HP:0001922)2.74262785
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.68636121
50Stomach cancer (HP:0012126)2.68575186
51Thrombocytosis (HP:0001894)2.66790658
52Vasculitis (HP:0002633)2.66386601
53Hyperventilation (HP:0002883)2.65913681
54Abnormal drinking behavior (HP:0030082)2.65416494
55Polydipsia (HP:0001959)2.65416494
56Recurrent lower respiratory tract infections (HP:0002783)2.62330043
57Periodontitis (HP:0000704)2.61357614
58Abnormal rod and cone electroretinograms (HP:0008323)2.59582775
59Abnormality of the renal medulla (HP:0100957)2.56958251
60Colitis (HP:0002583)2.53810779
61Keratoconjunctivitis sicca (HP:0001097)2.53777314
62Abnormality of the prostate (HP:0008775)2.53427271
63Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53084561
64Keratoconjunctivitis (HP:0001096)2.52396828
65Stomatitis (HP:0010280)2.49467068
66Clubbing of toes (HP:0100760)2.45173002
67Inflammation of the large intestine (HP:0002037)2.44057669
68Bile duct proliferation (HP:0001408)2.40360112
69Abnormal biliary tract physiology (HP:0012439)2.40360112
70Duplicated collecting system (HP:0000081)2.38772101
71Decreased circulating renin level (HP:0003351)2.38169942
72Tubular atrophy (HP:0000092)2.35204192
73Birth length less than 3rd percentile (HP:0003561)2.34821993
74Large for gestational age (HP:0001520)2.34009959
75Muscle fiber atrophy (HP:0100295)2.32984420
76Cellulitis (HP:0100658)2.31676743
77Reduced antithrombin III activity (HP:0001976)2.30905864
78Increased neuronal autofluorescent lipopigment (HP:0002074)2.28226871
79Abnormality of T cells (HP:0002843)2.26742205
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25899095
81Eosinophilia (HP:0001880)2.23662337
82Autoimmune thrombocytopenia (HP:0001973)2.23330329
83Basal ganglia calcification (HP:0002135)2.23069327
84Gastrointestinal inflammation (HP:0004386)2.22637362
85Hematochezia (HP:0002573)2.21474190
86Abnormality of the renal collecting system (HP:0004742)2.19201988
87Abnormality of chromosome stability (HP:0003220)2.19023607
88Albinism (HP:0001022)2.18808595
89Constricted visual fields (HP:0001133)2.18378676
90Renal cortical cysts (HP:0000803)2.17424181
91Furrowed tongue (HP:0000221)2.16936461
92Absent/shortened dynein arms (HP:0200106)2.16653962
93Dynein arm defect of respiratory motile cilia (HP:0012255)2.16653962
94Abnormality of T cell number (HP:0011839)2.15909485
95Gingival bleeding (HP:0000225)2.12552903
96Prolonged bleeding time (HP:0003010)2.12497100
97Abnormality of DNA repair (HP:0003254)2.12213732
98Cystic liver disease (HP:0006706)2.11954736
99T lymphocytopenia (HP:0005403)2.11145369
100Abnormality of the preputium (HP:0100587)2.11104257
101Type II lissencephaly (HP:0007260)2.11031372
102Congenital sensorineural hearing impairment (HP:0008527)2.10438211
103Polyuria (HP:0000103)2.09755475
104Chronic hepatic failure (HP:0100626)2.09553237
105Spontaneous hematomas (HP:0007420)2.08889423
106Leukocytosis (HP:0001974)2.07333697
107Abnormal spermatogenesis (HP:0008669)2.07113719
108Leukopenia (HP:0001882)2.06574960
109Chronic diarrhea (HP:0002028)2.06492579
110Gaze-evoked nystagmus (HP:0000640)2.05021610
111Pulmonary infiltrates (HP:0002113)2.04888511
112Medial flaring of the eyebrow (HP:0010747)2.01712908
113Thick nail (HP:0001805)2.01265194
114Abnormality of B cell number (HP:0010975)2.00672168
115Granulocytopenia (HP:0001913)2.00265109
116Clumsiness (HP:0002312)1.99599903
117IgG deficiency (HP:0004315)1.98982910
118Hypothermia (HP:0002045)1.97714634
119Bone marrow hypocellularity (HP:0005528)1.97676032
120Decreased central vision (HP:0007663)1.97344550
121Epistaxis (HP:0000421)1.96865538
122Acute myeloid leukemia (HP:0004808)1.96467626
123Azoospermia (HP:0000027)1.96402156
124Increased cerebral lipofuscin (HP:0011813)1.94952912
125Systemic lupus erythematosus (HP:0002725)1.94711582
126Abnormality of eosinophils (HP:0001879)1.94596288
127Thyroiditis (HP:0100646)1.94109792
128Prolonged neonatal jaundice (HP:0006579)1.93468767
129Type I transferrin isoform profile (HP:0003642)1.93311176
130Ketosis (HP:0001946)1.92785811
131Reticulocytopenia (HP:0001896)1.92722266
132Ketoacidosis (HP:0001993)1.92590755
133Osteomyelitis (HP:0002754)1.92239541
134Arterial thrombosis (HP:0004420)1.91045030
135Hemoptysis (HP:0002105)1.91021889
136Ectopic kidney (HP:0000086)1.90779791
137Genetic anticipation (HP:0003743)1.90678595
138Urticaria (HP:0001025)1.90618649
139Myelodysplasia (HP:0002863)1.90104985
140Agitation (HP:0000713)1.89457053
141Cheilitis (HP:0100825)1.89411626
142Recurrent bronchitis (HP:0002837)1.89197736
143Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88956443
144Abnormality of polysaccharide metabolism (HP:0011012)1.88956443
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88956443
146Global brain atrophy (HP:0002283)1.87390292
147Increased IgE level (HP:0003212)1.87389526
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.87357646
149Dysostosis multiplex (HP:0000943)1.86935113
150Hepatosplenomegaly (HP:0001433)1.86593007
151Patchy hypopigmentation of hair (HP:0011365)1.86523212
152Congenital hepatic fibrosis (HP:0002612)1.84590198
153Hypergammaglobulinemia (HP:0010702)1.83811006
154White forelock (HP:0002211)1.83652997
155Neutropenia (HP:0001875)1.83480398
156Lymphoma (HP:0002665)1.83467424
157Skin ulcer (HP:0200042)1.83365741
158Progressive cerebellar ataxia (HP:0002073)1.80830588
159Progressive inability to walk (HP:0002505)1.79427579
160Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75388064
161Abnormality of alanine metabolism (HP:0010916)1.75388064
162Hyperalaninemia (HP:0003348)1.75388064
163Inability to walk (HP:0002540)1.75033609
164Congenital, generalized hypertrichosis (HP:0004540)1.73592933
165Macular degeneration (HP:0000608)1.73452424
166Generalized hypopigmentation of hair (HP:0011358)1.71975703
167Abnormality of macular pigmentation (HP:0008002)1.71668103
168Metabolic alkalosis (HP:0200114)1.71350515
169Abnormal urine output (HP:0012590)1.71005601
170Widely spaced teeth (HP:0000687)1.69903556
171Fair hair (HP:0002286)1.69266925
172Aplasia/Hypoplasia of the fovea (HP:0008060)1.67712055
173Hypoplasia of the fovea (HP:0007750)1.67712055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.15162382
2IRAK43.89537855
3MAP3K143.10428565
4BLK3.06414026
5IRAK32.90382545
6KIT2.73685036
7MAP4K22.54339942
8TYK22.43703760
9TEC2.39284551
10MAP4K12.22121212
11STK162.12270024
12PINK12.06790597
13TXK2.04192213
14TAOK32.01768254
15IKBKE2.00601847
16MKNK22.00531807
17BTK1.87991656
18IKBKB1.83239817
19ZAK1.78748195
20RIPK41.77852851
21JAK31.74881717
22TBK11.73093810
23DAPK21.69680625
24CLK11.69164342
25TLK11.65553313
26CSF1R1.59932155
27MKNK11.59912866
28EIF2AK21.57509734
29NUAK11.51387561
30BRSK21.49481615
31WEE11.49274857
32WNK41.48440924
33INSRR1.39735292
34WNK31.39308485
35NEK91.35766646
36SYK1.34785846
37MAP3K131.34065860
38ADRBK21.32692057
39STK41.32632522
40OXSR11.26725137
41PIM11.23719071
42LYN1.21506586
43PIM21.20324763
44JAK11.16287745
45TNK21.16265913
46NME21.16203345
47ZAP701.13862880
48FLT31.12136599
49TGFBR21.12132552
50PLK41.11952596
51MAPK131.08774838
52SRPK11.08509152
53MATK1.08033292
54CHUK1.06305438
55PIK3CG1.05250635
56RPS6KA41.05220199
57ADRBK11.03457311
58NLK1.02911927
59BUB11.02627109
60TRPM70.99570970
61CSK0.96780797
62MST40.94809754
63STK100.93431893
64EIF2AK30.92928799
65DYRK30.90725129
66YES10.89855541
67LCK0.88804950
68TNIK0.88573281
69ACVR1B0.88545967
70ATR0.86892469
71TAOK20.85400084
72PBK0.85176377
73VRK10.84712093
74HCK0.84551507
75IRAK10.82076952
76STK390.81820154
77MAPKAPK30.79585162
78TGFBR10.77501123
79NEK20.77136481
80NTRK30.76744012
81BMPR1B0.75656324
82PIK3CA0.74233814
83PRKCE0.73732505
84STK30.73268275
85CCNB10.72814382
86MARK30.72698792
87ITK0.71755424
88PTK2B0.71263674
89GRK70.69419678
90MAP2K30.68141786
91STK240.67207346
92BMPR20.65788284
93MAPK150.64647484
94CASK0.61677806
95GRK60.61050189
96PAK30.60834674
97CDK30.60783541
98RPS6KA50.59115033
99SGK20.58779072
100GRK10.58756810
101CDC70.54301210
102SIK30.54091230
103FES0.53471709
104PRKCG0.53178162
105PRKAA20.52513334
106IRAK20.51383049
107JAK20.51266804
108MAPK110.50703834
109EPHA30.50445297
110PLK10.49492771
111MAP3K30.49206926
112ABL20.46433641
113BRD40.45768697
114MUSK0.45667724
115MAP3K50.44707731
116STK110.44671141
117FER0.44298255
118IGF1R0.43753126
119PKN10.42972318
120FGFR30.42957593
121AURKB0.42760144
122TIE10.41855778
123PRKCD0.41355590
124ABL10.40967793
125BCKDK0.40078007
126CDK70.39783761
127RPS6KA60.39193229
128MAP2K60.38411774
129ERBB30.37765307
130CSNK1G20.37394150
131CDK40.37142957
132STK38L0.36051624
133PRKCA0.35876421
134MAPK40.35273583
135CSNK1G10.35255085
136MAPKAPK50.35199499
137PRKACA0.34512744
138HIPK20.34007925
139MAP3K20.33384968
140FGR0.33211977
141PRKCQ0.32783262
142MAPKAPK20.32318647
143BRSK10.32316997
144CAMKK20.32222554
145PRKG10.29680147
146PNCK0.28897122

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.05548246
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.54066984
3Leishmaniasis_Homo sapiens_hsa051402.50461420
4DNA replication_Homo sapiens_hsa030302.20162490
5Primary immunodeficiency_Homo sapiens_hsa053402.19110278
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09823577
7Linoleic acid metabolism_Homo sapiens_hsa005912.06619252
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.00570871
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.98592521
10Herpes simplex infection_Homo sapiens_hsa051681.97995547
11Measles_Homo sapiens_hsa051621.97872570
12Tryptophan metabolism_Homo sapiens_hsa003801.94257319
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.93164235
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92865247
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90332170
16Homologous recombination_Homo sapiens_hsa034401.88257246
17Caffeine metabolism_Homo sapiens_hsa002321.86656459
18Antigen processing and presentation_Homo sapiens_hsa046121.84535575
19Graft-versus-host disease_Homo sapiens_hsa053321.83994729
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.82825362
21Staphylococcus aureus infection_Homo sapiens_hsa051501.81071437
22Phototransduction_Homo sapiens_hsa047441.78143805
23Influenza A_Homo sapiens_hsa051641.73136718
24Allograft rejection_Homo sapiens_hsa053301.72932189
25Hematopoietic cell lineage_Homo sapiens_hsa046401.71938730
26Fanconi anemia pathway_Homo sapiens_hsa034601.71587488
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.67348475
28Osteoclast differentiation_Homo sapiens_hsa043801.66811867
29Mismatch repair_Homo sapiens_hsa034301.65640905
30Non-homologous end-joining_Homo sapiens_hsa034501.62953139
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.62817436
32Pertussis_Homo sapiens_hsa051331.61943115
33Base excision repair_Homo sapiens_hsa034101.61026077
34Nitrogen metabolism_Homo sapiens_hsa009101.59707105
35Legionellosis_Homo sapiens_hsa051341.54907644
36RNA polymerase_Homo sapiens_hsa030201.53356112
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51683857
38Malaria_Homo sapiens_hsa051441.49141632
39Butanoate metabolism_Homo sapiens_hsa006501.47655321
40Vitamin B6 metabolism_Homo sapiens_hsa007501.45282222
41Other glycan degradation_Homo sapiens_hsa005111.44541907
42B cell receptor signaling pathway_Homo sapiens_hsa046621.44070564
43Tuberculosis_Homo sapiens_hsa051521.42733303
44Asthma_Homo sapiens_hsa053101.41180706
45Collecting duct acid secretion_Homo sapiens_hsa049661.39980739
46Basal transcription factors_Homo sapiens_hsa030221.38202619
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33546200
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32199502
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31526950
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.28364094
51Lysosome_Homo sapiens_hsa041421.21158145
52Toxoplasmosis_Homo sapiens_hsa051451.20646219
53Vitamin digestion and absorption_Homo sapiens_hsa049771.19039102
54Pyrimidine metabolism_Homo sapiens_hsa002401.14194374
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13715527
56Dorso-ventral axis formation_Homo sapiens_hsa043201.11944598
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10353186
58TNF signaling pathway_Homo sapiens_hsa046681.10149267
59Cell cycle_Homo sapiens_hsa041101.09248888
60Nucleotide excision repair_Homo sapiens_hsa034201.08954729
61p53 signaling pathway_Homo sapiens_hsa041151.07665016
62Apoptosis_Homo sapiens_hsa042101.05558835
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.01852068
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01528061
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00922343
66Proteasome_Homo sapiens_hsa030501.00553024
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99833189
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99645700
69Sulfur metabolism_Homo sapiens_hsa009200.99396348
70Hepatitis B_Homo sapiens_hsa051610.98517196
71Selenocompound metabolism_Homo sapiens_hsa004500.97275346
72Peroxisome_Homo sapiens_hsa041460.96557564
73Rheumatoid arthritis_Homo sapiens_hsa053230.96545427
74Chemical carcinogenesis_Homo sapiens_hsa052040.95693066
75Phagosome_Homo sapiens_hsa041450.94820142
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94524860
77Chemokine signaling pathway_Homo sapiens_hsa040620.92731342
78Autoimmune thyroid disease_Homo sapiens_hsa053200.92202335
79Epstein-Barr virus infection_Homo sapiens_hsa051690.90286945
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87949839
81African trypanosomiasis_Homo sapiens_hsa051430.87097085
82Salmonella infection_Homo sapiens_hsa051320.86016553
83Histidine metabolism_Homo sapiens_hsa003400.85999404
84Mineral absorption_Homo sapiens_hsa049780.84497680
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83391883
86Spliceosome_Homo sapiens_hsa030400.82415701
87Protein export_Homo sapiens_hsa030600.80982119
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79787559
89Shigellosis_Homo sapiens_hsa051310.78544961
90Regulation of autophagy_Homo sapiens_hsa041400.77840751
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77500095
92Sphingolipid metabolism_Homo sapiens_hsa006000.77207660
93Glycerolipid metabolism_Homo sapiens_hsa005610.76095518
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75448682
95Oxidative phosphorylation_Homo sapiens_hsa001900.75133661
96Arachidonic acid metabolism_Homo sapiens_hsa005900.74719196
97Hepatitis C_Homo sapiens_hsa051600.74439789
98RNA degradation_Homo sapiens_hsa030180.71966446
99Retinol metabolism_Homo sapiens_hsa008300.71449927
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70764998
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.69845121
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68683494
103Serotonergic synapse_Homo sapiens_hsa047260.65606284
104ABC transporters_Homo sapiens_hsa020100.65205367
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64243168
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63780203
107Ovarian steroidogenesis_Homo sapiens_hsa049130.63677696
108Purine metabolism_Homo sapiens_hsa002300.62624335
109Systemic lupus erythematosus_Homo sapiens_hsa053220.61410370
110Viral carcinogenesis_Homo sapiens_hsa052030.61072674
111Morphine addiction_Homo sapiens_hsa050320.59340304
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58434218
113Small cell lung cancer_Homo sapiens_hsa052220.57881666
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57288044
115Olfactory transduction_Homo sapiens_hsa047400.56570099
116Taste transduction_Homo sapiens_hsa047420.55312337
117Salivary secretion_Homo sapiens_hsa049700.54953454
118One carbon pool by folate_Homo sapiens_hsa006700.54810552
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54760857
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54678719
121Acute myeloid leukemia_Homo sapiens_hsa052210.53393735
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52471037
123RNA transport_Homo sapiens_hsa030130.51906699
124Insulin secretion_Homo sapiens_hsa049110.51414289
125Ribosome_Homo sapiens_hsa030100.51302930
126T cell receptor signaling pathway_Homo sapiens_hsa046600.49738145
127Type I diabetes mellitus_Homo sapiens_hsa049400.49627627
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49338961
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48543545
130Nicotine addiction_Homo sapiens_hsa050330.46100184
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44592442
132Platelet activation_Homo sapiens_hsa046110.43383764
133beta-Alanine metabolism_Homo sapiens_hsa004100.41459313
134Folate biosynthesis_Homo sapiens_hsa007900.41289139
135HTLV-I infection_Homo sapiens_hsa051660.40899916
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40809591
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.40724901
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39784074
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38599547
140Glutamatergic synapse_Homo sapiens_hsa047240.38576578
141Fatty acid degradation_Homo sapiens_hsa000710.37601534
142Viral myocarditis_Homo sapiens_hsa054160.37250731
143Renin secretion_Homo sapiens_hsa049240.36201477
144Ether lipid metabolism_Homo sapiens_hsa005650.34277918
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33433868
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31164660
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.27568867

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