SGK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.64120277
2L-phenylalanine catabolic process (GO:0006559)7.64120277
3L-phenylalanine metabolic process (GO:0006558)7.20275349
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.20275349
5aromatic amino acid family catabolic process (GO:0009074)6.68715041
6glyoxylate metabolic process (GO:0046487)6.07239670
7epoxygenase P450 pathway (GO:0019373)5.87836338
8tryptophan catabolic process (GO:0006569)5.81705954
9indole-containing compound catabolic process (GO:0042436)5.81705954
10indolalkylamine catabolic process (GO:0046218)5.81705954
11bile acid biosynthetic process (GO:0006699)5.51194784
12cysteine metabolic process (GO:0006534)5.49893226
13tryptophan metabolic process (GO:0006568)5.46530713
14kynurenine metabolic process (GO:0070189)5.46148515
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.11562432
16sulfur amino acid catabolic process (GO:0000098)5.06695474
17alpha-linolenic acid metabolic process (GO:0036109)5.06112107
18lysine catabolic process (GO:0006554)4.83755365
19lysine metabolic process (GO:0006553)4.83755365
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.82742923
21aromatic amino acid family metabolic process (GO:0009072)4.82296998
22omega-hydroxylase P450 pathway (GO:0097267)4.79817247
23serine family amino acid catabolic process (GO:0009071)4.74844200
24drug transmembrane transport (GO:0006855)4.69516564
25bile acid metabolic process (GO:0008206)4.68737220
26homocysteine metabolic process (GO:0050667)4.62466713
27urea cycle (GO:0000050)4.61817211
28urea metabolic process (GO:0019627)4.61817211
29cellular ketone body metabolic process (GO:0046950)4.53435127
30tyrosine metabolic process (GO:0006570)4.52909424
31high-density lipoprotein particle remodeling (GO:0034375)4.47801312
32negative regulation of fibrinolysis (GO:0051918)4.44155168
33urate metabolic process (GO:0046415)4.41926671
34peptidyl-glutamic acid carboxylation (GO:0017187)4.40835596
35protein carboxylation (GO:0018214)4.40835596
36alpha-amino acid catabolic process (GO:1901606)4.40078579
37drug catabolic process (GO:0042737)4.37906760
38nitrogen cycle metabolic process (GO:0071941)4.33815006
39short-chain fatty acid metabolic process (GO:0046459)4.32345079
40amino-acid betaine metabolic process (GO:0006577)4.31494566
41regulation of fibrinolysis (GO:0051917)4.30476023
42complement activation, alternative pathway (GO:0006957)4.21084148
43coenzyme catabolic process (GO:0009109)4.20004361
44indolalkylamine metabolic process (GO:0006586)4.18758197
45glutamate metabolic process (GO:0006536)4.17265461
46cellular amino acid catabolic process (GO:0009063)4.14375140
47ethanol metabolic process (GO:0006067)4.14259750
48regulation of protein activation cascade (GO:2000257)4.13985576
49serine family amino acid metabolic process (GO:0009069)4.12612246
50cellular glucuronidation (GO:0052695)4.12306619
51regulation of triglyceride catabolic process (GO:0010896)4.11504911
52low-density lipoprotein particle clearance (GO:0034383)4.08908366
53cellular biogenic amine catabolic process (GO:0042402)4.07994288
54amine catabolic process (GO:0009310)4.07994288
55acetyl-CoA metabolic process (GO:0006084)4.07387558
56diacylglycerol metabolic process (GO:0046339)4.05550594
57regulation of cholesterol esterification (GO:0010872)4.05326272
58triglyceride homeostasis (GO:0070328)4.03676340
59acylglycerol homeostasis (GO:0055090)4.03676340
60bile acid and bile salt transport (GO:0015721)4.01511996
61phospholipid homeostasis (GO:0055091)3.99328646
62cellular modified amino acid catabolic process (GO:0042219)3.98137834
63triglyceride catabolic process (GO:0019433)3.98079910
64blood coagulation, intrinsic pathway (GO:0007597)3.97923460
65intestinal absorption (GO:0050892)3.97025982
66negative regulation of cholesterol transport (GO:0032375)3.96440276
67negative regulation of sterol transport (GO:0032372)3.96440276
68serine family amino acid biosynthetic process (GO:0009070)3.95873390
69phenylpropanoid metabolic process (GO:0009698)3.95434521
70ketone body metabolic process (GO:1902224)3.94307688
71very-low-density lipoprotein particle assembly (GO:0034379)3.91189750
72ethanol oxidation (GO:0006069)3.89822604
73aspartate family amino acid catabolic process (GO:0009068)3.89291275
74very long-chain fatty acid metabolic process (GO:0000038)3.87660992
75aldehyde catabolic process (GO:0046185)3.87343704
76reverse cholesterol transport (GO:0043691)3.86534107
77fibrinolysis (GO:0042730)3.85852944
78exogenous drug catabolic process (GO:0042738)3.85733866
79regulation of complement activation (GO:0030449)3.85680121
80heme transport (GO:0015886)3.85508192
81neutral lipid catabolic process (GO:0046461)3.83676421
82acylglycerol catabolic process (GO:0046464)3.83676421
83plasma lipoprotein particle remodeling (GO:0034369)3.83404053
84protein-lipid complex remodeling (GO:0034368)3.83404053
85macromolecular complex remodeling (GO:0034367)3.83404053
86benzene-containing compound metabolic process (GO:0042537)3.82755018
87plasma lipoprotein particle clearance (GO:0034381)3.81097048
88drug transport (GO:0015893)3.80785508
89fatty acid elongation (GO:0030497)3.79972539
90glucuronate metabolic process (GO:0019585)3.79349922
91uronic acid metabolic process (GO:0006063)3.79349922
92phospholipid efflux (GO:0033700)3.73796524
93protein activation cascade (GO:0072376)3.71469455
94glycine metabolic process (GO:0006544)3.71404210
95acute-phase response (GO:0006953)3.70682614
96organic acid catabolic process (GO:0016054)3.70589915
97carboxylic acid catabolic process (GO:0046395)3.70589915
98regulation of bile acid biosynthetic process (GO:0070857)3.69380222
99intestinal cholesterol absorption (GO:0030299)3.68987421
100negative regulation of lipase activity (GO:0060192)3.68081336
101positive regulation of lipid catabolic process (GO:0050996)3.66992798
102response to mercury ion (GO:0046689)3.66959963
103fatty acid beta-oxidation (GO:0006635)3.64137548
104cholesterol efflux (GO:0033344)3.59520739
105complement activation, classical pathway (GO:0006958)3.57216375
106cofactor catabolic process (GO:0051187)3.56836787
107fatty acid oxidation (GO:0019395)3.56810603
108fatty acid homeostasis (GO:0055089)3.55728905
109monocarboxylic acid catabolic process (GO:0072329)3.53407080
110regulation of cholesterol homeostasis (GO:2000188)3.53065211
111imidazole-containing compound metabolic process (GO:0052803)3.52470312
112plasma lipoprotein particle organization (GO:0071827)3.51868440
113negative regulation of protein activation cascade (GO:2000258)3.50933713
114fatty acid catabolic process (GO:0009062)3.50309851
115regulation of plasminogen activation (GO:0010755)3.50182641
116lipid oxidation (GO:0034440)3.49814488
117positive regulation of lipoprotein lipase activity (GO:0051006)3.48450638
118positive regulation of triglyceride lipase activity (GO:0061365)3.48450638
119flavonoid metabolic process (GO:0009812)3.48102390
120negative regulation of blood coagulation (GO:0030195)3.47764118
121negative regulation of hemostasis (GO:1900047)3.47764118
122dicarboxylic acid biosynthetic process (GO:0043650)3.47157850
123drug metabolic process (GO:0017144)3.46564356
124arginine metabolic process (GO:0006525)3.45414538
125complement activation (GO:0006956)3.45125182
126cholesterol homeostasis (GO:0042632)3.44401055
127sterol homeostasis (GO:0055092)3.40754361
128plasma lipoprotein particle assembly (GO:0034377)3.40468229
129aminoglycoside antibiotic metabolic process (GO:0030647)3.38619279
130protein-lipid complex subunit organization (GO:0071825)3.36835882
131primary alcohol catabolic process (GO:0034310)3.36414414
132polyketide metabolic process (GO:0030638)3.35812907
133doxorubicin metabolic process (GO:0044598)3.35812907
134daunorubicin metabolic process (GO:0044597)3.35812907
135oxidative demethylation (GO:0070989)3.35492852
136biotin metabolic process (GO:0006768)3.34217455
137primary alcohol metabolic process (GO:0034308)3.33108798
138negative regulation of coagulation (GO:0050819)3.27334189
139regulation of humoral immune response (GO:0002920)3.16163207
140protein-lipid complex assembly (GO:0065005)3.14175230
141negative regulation of wound healing (GO:0061045)3.13651544
142positive regulation of blood coagulation (GO:0030194)3.11411586
143positive regulation of hemostasis (GO:1900048)3.11411586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.33225272
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.18927726
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.98638895
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.79691257
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.66338323
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.12311464
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.85295201
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.48594082
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.38166730
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2274482
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85315196
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.85160430
13* FOXA2_19822575_ChIP-Seq_HepG2_Human1.66719656
14* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62789199
15HTT_18923047_ChIP-ChIP_STHdh_Human1.50627521
16ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42148314
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38386402
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.35995531
19SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34274862
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33491594
21GATA6_25053715_ChIP-Seq_YYC3_Human1.29710963
22* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27872857
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27667798
24CLOCK_20551151_ChIP-Seq_293T_Human1.23022723
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21858101
26ZNF263_19887448_ChIP-Seq_K562_Human1.14676453
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14031863
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.11410051
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06927486
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05132857
31NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05132857
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00172666
33TAF15_26573619_Chip-Seq_HEK293_Human0.99424497
34GATA4_25053715_ChIP-Seq_YYC3_Human0.96985560
35ESR2_21235772_ChIP-Seq_MCF-7_Human0.96950223
36TCF4_18268006_ChIP-ChIP_LS174T_Human0.95973239
37* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89805504
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89566688
39CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88835355
40RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88639200
41* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86532803
42AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86312658
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85263504
44AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84863838
45FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84567332
46* LXR_22292898_ChIP-Seq_THP-1_Human0.83791694
47SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83246848
48BCAT_22108803_ChIP-Seq_LS180_Human0.83087788
49GATA2_21666600_ChIP-Seq_HMVEC_Human0.82061338
50CDX2_20551321_ChIP-Seq_CACO-2_Human0.81792245
51TP53_16413492_ChIP-PET_HCT116_Human0.80156773
52EGR1_19032775_ChIP-ChIP_M12_Human0.80141109
53SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79308258
54FOXA1_25552417_ChIP-Seq_VCAP_Human0.78471512
55KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77602647
56HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76887898
57GATA3_24758297_ChIP-Seq_MCF-7_Human0.76863932
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75815057
59DROSHA_22980978_ChIP-Seq_HELA_Human0.75812143
60* SOX2_20726797_ChIP-Seq_SW620_Human0.75767804
61CDX2_19796622_ChIP-Seq_MESCs_Mouse0.74512340
62PIAS1_25552417_ChIP-Seq_VCAP_Human0.74272373
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.73716268
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73534325
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73441744
66P63_26484246_Chip-Seq_KERATINOCYTES_Human0.72321239
67FOXO3_23340844_ChIP-Seq_DLD1_Human0.72036739
68CBP_21632823_ChIP-Seq_H3396_Human0.71877750
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.71653339
70* MYC_19915707_ChIP-ChIP_AK7_Human0.70483025
71ESR1_21235772_ChIP-Seq_MCF-7_Human0.70304269
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.69653221
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69049670
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.68785923
75IGF1R_20145208_ChIP-Seq_DFB_Human0.68747549
76RARG_19884340_ChIP-ChIP_MEFs_Mouse0.68232046
77CJUN_26792858_Chip-Seq_BT549_Human0.67466484
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66981965
79RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66582674
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66535857
81RACK7_27058665_Chip-Seq_MCF-7_Human0.66455035
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.65145243
83CTCF_27219007_Chip-Seq_Bcells_Human0.64779026
84ESR1_20079471_ChIP-ChIP_T-47D_Human0.64562912
85DNAJC2_21179169_ChIP-ChIP_NT2_Human0.64530100
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64498281
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63769087
88KLF5_25053715_ChIP-Seq_YYC3_Human0.62950717
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62741066
90EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.62516613
91RXR_22108803_ChIP-Seq_LS180_Human0.61609339
92ESET_19884257_ChIP-Seq_ESCs_Mouse0.60873760
93PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60340156
94CEBPB_22108803_ChIP-Seq_LS180_Human0.60229054
95* TBX20_22080862_ChIP-Seq_HEART_Mouse0.60168638
96* TBX20_22328084_ChIP-Seq_HEART_Mouse0.60168638
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59763658
98SOX9_24532713_ChIP-Seq_HFSC_Mouse0.59560849
99MTF2_20144788_ChIP-Seq_MESCs_Mouse0.59353014
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.58575751
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.58531110
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.58408734
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58089250
104NCOR_22424771_ChIP-Seq_293T_Human0.57971750
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.57908463
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.57468162
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.57416000
108CDX2_22108803_ChIP-Seq_LS180_Human0.57250460
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.56817975
110SOX2_19829295_ChIP-Seq_ESCs_Human0.56238001
111NANOG_19829295_ChIP-Seq_ESCs_Human0.56238001
112GATA1_22025678_ChIP-Seq_K562_Human0.56179783
113OCT4_20526341_ChIP-Seq_ESCs_Human0.55722090
114ETV2_25802403_ChIP-Seq_MESCs_Mouse0.55377345
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.54920578
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.54675277
117STAT1_17558387_ChIP-Seq_HELA_Human0.53767081
118GATA1_19941826_ChIP-Seq_K562_Human0.53516901
119SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.53252032
120RARA_24833708_ChIP-Seq_LIVER_Mouse0.52669963
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.51693338
122TRIM28_21343339_ChIP-Seq_HEK293_Human0.51681853
123GBX2_23144817_ChIP-Seq_PC3_Human0.50604288
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.50447902
125GATA2_19941826_ChIP-Seq_K562_Human0.50327062
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.50159344
127P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.50018350
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.49563436
129AR_20517297_ChIP-Seq_VCAP_Human0.49236001
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.48937108
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48043255
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.47852012
133VDR_22108803_ChIP-Seq_LS180_Human0.47362741
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.47325673
135TAF2_19829295_ChIP-Seq_ESCs_Human0.47242908
136P53_21459846_ChIP-Seq_SAOS-2_Human0.47229925
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.46239285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.81724325
2MP0005360_urolithiasis7.68525758
3MP0005085_abnormal_gallbladder_physiolo5.87247857
4MP0005365_abnormal_bile_salt5.62962436
5MP0008875_abnormal_xenobiotic_pharmacok4.89894682
6MP0003806_abnormal_nucleotide_metabolis4.40396886
7MP0003252_abnormal_bile_duct3.67605869
8MP0003195_calcinosis3.57839406
9MP0005332_abnormal_amino_acid3.22542229
10MP0010329_abnormal_lipoprotein_level2.95665243
11MP0009840_abnormal_foam_cell2.75230363
12MP0001666_abnormal_nutrient_absorption2.73058492
13MP0004019_abnormal_vitamin_homeostasis2.64758808
14MP0005083_abnormal_biliary_tract2.52361186
15MP0002138_abnormal_hepatobiliary_system2.14631441
16MP0003191_abnormal_cellular_cholesterol2.12419698
17MP0002118_abnormal_lipid_homeostasis2.06112875
18MP0005451_abnormal_body_composition1.98409494
19MP0004043_abnormal_pH_regulation1.95230947
20MP0000609_abnormal_liver_physiology1.82616609
21MP0009643_abnormal_urine_homeostasis1.77749110
22MP0003868_abnormal_feces_composition1.75618275
23MP0005584_abnormal_enzyme/coenzyme_acti1.65157150
24MP0005319_abnormal_enzyme/_coenzyme1.61061530
25MP0001764_abnormal_homeostasis1.54055621
26MP0005375_adipose_tissue_phenotype1.42573228
27MP0005409_darkened_coat_color1.42028371
28MP0009115_abnormal_fat_cell1.36963461
29MP0003690_abnormal_glial_cell1.36223721
30MP0005636_abnormal_mineral_homeostasis1.35810886
31MP0003186_abnormal_redox_activity1.29249304
32MP0003879_abnormal_hair_cell1.28501123
33MP0004185_abnormal_adipocyte_glucose1.24673258
34MP0002132_abnormal_respiratory_system1.22396233
35MP0000920_abnormal_myelination1.21135611
36MP0000604_amyloidosis1.19105580
37MP0003329_amyloid_beta_deposits1.16348263
38MP0000566_synostosis1.12854347
39MP0009697_abnormal_copulation1.12347871
40MP0002970_abnormal_white_adipose1.09010328
41MP0004272_abnormal_basement_membrane1.03743680
42MP0009780_abnormal_chondrocyte_physiolo1.03562229
43MP0003183_abnormal_peptide_metabolism1.02346715
44MP0001756_abnormal_urination1.01892863
45MP0001661_extended_life_span1.01819210
46MP0005408_hypopigmentation1.01175926
47MP0002909_abnormal_adrenal_gland1.00545812
48MP0003011_delayed_dark_adaptation1.00271761
49MP0003656_abnormal_erythrocyte_physiolo0.97863936
50MP0001765_abnormal_ion_homeostasis0.90304180
51MP0005084_abnormal_gallbladder_morpholo0.90279265
52MP0003959_abnormal_lean_body0.90258113
53MP0010234_abnormal_vibrissa_follicle0.89357804
54MP0000598_abnormal_liver_morphology0.88653947
55MP0005647_abnormal_sex_gland0.85351987
56MP0000003_abnormal_adipose_tissue0.85089750
57MP0009642_abnormal_blood_homeostasis0.83478622
58MP0002136_abnormal_kidney_physiology0.83324815
59MP0006036_abnormal_mitochondrial_physio0.82769377
60MP0009764_decreased_sensitivity_to0.82547974
61MP0002876_abnormal_thyroid_physiology0.81839844
62MP0004147_increased_porphyrin_level0.80390687
63MP0002822_catalepsy0.78562831
64MP0005670_abnormal_white_adipose0.78447844
65MP0009763_increased_sensitivity_to0.78201830
66MP0009765_abnormal_xenobiotic_induced0.78031086
67MP0010386_abnormal_urinary_bladder0.75002622
68MP0008469_abnormal_protein_level0.73444916
69MP0005535_abnormal_body_temperature0.72853060
70MP0004885_abnormal_endolymph0.70880271
71MP0002078_abnormal_glucose_homeostasis0.70688967
72MP0005058_abnormal_lysosome_morphology0.69255149
73MP0005379_endocrine/exocrine_gland_phen0.65789454
74MP0005376_homeostasis/metabolism_phenot0.65229441
75MP0002971_abnormal_brown_adipose0.64493944
76MP0005220_abnormal_exocrine_pancreas0.64480208
77MP0001664_abnormal_digestion0.63635334
78MP0005452_abnormal_adipose_tissue0.62802810
79MP0001944_abnormal_pancreas_morphology0.61674813
80MP0004381_abnormal_hair_follicle0.59877838
81MP0000462_abnormal_digestive_system0.59874811
82MP0005164_abnormal_response_to0.57601574
83MP0000230_abnormal_systemic_arterial0.56093502
84MP0002089_abnormal_postnatal_growth/wei0.55621680
85MP0002796_impaired_skin_barrier0.54124496
86MP0005334_abnormal_fat_pad0.53415044
87MP0002254_reproductive_system_inflammat0.52476290
88MP0005503_abnormal_tendon_morphology0.51187498
89MP0005666_abnormal_adipose_tissue0.50881308
90MP0005395_other_phenotype0.50860158
91MP0005266_abnormal_metabolism0.50258876
92MP0000249_abnormal_blood_vessel0.48072052
93MP0006138_congestive_heart_failure0.47820513
94MP0000639_abnormal_adrenal_gland0.47561579
95MP0002168_other_aberrant_phenotype0.45209025
96MP0006082_CNS_inflammation0.44915765
97MP0000538_abnormal_urinary_bladder0.44361361
98MP0003638_abnormal_response/metabolism_0.44210093
99MP0008874_decreased_physiological_sensi0.43538014
100MP0010368_abnormal_lymphatic_system0.43073736
101MP0003866_abnormal_defecation0.41538755
102MP0004142_abnormal_muscle_tone0.40767606
103MP0008873_increased_physiological_sensi0.40441358
104MP0004883_abnormal_blood_vessel0.40263596
105MP0006035_abnormal_mitochondrial_morpho0.40170892
106MP0003632_abnormal_nervous_system0.39774032
107MP0005023_abnormal_wound_healing0.39692005
108MP0003953_abnormal_hormone_level0.39665654
109MP0003724_increased_susceptibility_to0.39286543
110MP0003950_abnormal_plasma_membrane0.39004916
111MP0002229_neurodegeneration0.38950598
112MP0009672_abnormal_birth_weight0.38464214
113MP0004130_abnormal_muscle_cell0.38412681
114MP0003718_maternal_effect0.37087826
115MP0002069_abnormal_eating/drinking_beha0.36950345
116MP0003075_altered_response_to0.35484017
117MP0003300_gastrointestinal_ulcer0.34458339
118MP0001501_abnormal_sleep_pattern0.34342493
119MP0000477_abnormal_intestine_morphology0.34309519
120MP0005167_abnormal_blood-brain_barrier0.34287582
121MP0005448_abnormal_energy_balance0.33868916
122MP0001177_atelectasis0.33836132
123MP0001663_abnormal_digestive_system0.32931574
124MP0004264_abnormal_extraembryonic_tissu0.32755027
125MP0002928_abnormal_bile_duct0.31600489
126MP0002295_abnormal_pulmonary_circulatio0.31501618
127MP0003705_abnormal_hypodermis_morpholog0.30655807
128MP0005166_decreased_susceptibility_to0.30124819
129MP0009384_cardiac_valve_regurgitation0.29764836
130MP0004782_abnormal_surfactant_physiolog0.29387176
131MP0000579_abnormal_nail_morphology0.28807764
132MP0005551_abnormal_eye_electrophysiolog0.28564101
133MP0008872_abnormal_physiological_respon0.27936331
134MP0003631_nervous_system_phenotype0.27392572

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.92404085
2Intrahepatic cholestasis (HP:0001406)6.81903144
3Deep venous thrombosis (HP:0002625)5.95728719
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.65011513
5Xanthomatosis (HP:0000991)5.41468501
6Prolonged partial thromboplastin time (HP:0003645)5.15079524
7Hypobetalipoproteinemia (HP:0003563)5.10292118
8Hyperlipoproteinemia (HP:0010980)4.59669807
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.45788238
10Glomerulonephritis (HP:0000099)4.38516586
11Abnormality of aspartate family amino acid metabolism (HP:0010899)4.33900137
12Abnormality of serine family amino acid metabolism (HP:0010894)4.18980902
13Abnormality of glycine metabolism (HP:0010895)4.18980902
14Hyperammonemia (HP:0001987)4.18465311
15Ketosis (HP:0001946)4.18288108
16Hyperglycinuria (HP:0003108)4.16484620
17Hyperglycinemia (HP:0002154)4.06234510
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.01062111
19Complement deficiency (HP:0004431)4.00533707
20Fat malabsorption (HP:0002630)3.91455684
21Abnormality of methionine metabolism (HP:0010901)3.83143527
22Joint hemorrhage (HP:0005261)3.78959164
23Hypolipoproteinemia (HP:0010981)3.70831472
24Epidermoid cyst (HP:0200040)3.67279511
25Hemorrhage of the eye (HP:0011885)3.65192021
26Abnormality of fatty-acid metabolism (HP:0004359)3.63265467
27Hypoglycemic coma (HP:0001325)3.49805607
28Gout (HP:0001997)3.49629600
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.48808731
30Conjugated hyperbilirubinemia (HP:0002908)3.37418916
31Abnormality of the common coagulation pathway (HP:0010990)3.36243502
32Ketoacidosis (HP:0001993)3.34581492
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.25966482
34Nephritis (HP:0000123)3.24681547
35Delayed CNS myelination (HP:0002188)3.17712618
36Abnormality of purine metabolism (HP:0004352)3.17344652
37Hypoalphalipoproteinemia (HP:0003233)3.12723986
38Abnormality of nucleobase metabolism (HP:0010932)3.09929364
39Alkalosis (HP:0001948)3.07865876
40Steatorrhea (HP:0002570)3.04537367
41Vascular calcification (HP:0004934)3.02570787
42Abnormality of pyrimidine metabolism (HP:0004353)2.95098788
43Hyperbilirubinemia (HP:0002904)2.93893464
44Hypercholesterolemia (HP:0003124)2.88932731
45Dicarboxylic aciduria (HP:0003215)2.85464375
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.85464375
47Metabolic acidosis (HP:0001942)2.82584880
48Abnormality of the intrinsic pathway (HP:0010989)2.82479411
49Abnormality of serum amino acid levels (HP:0003112)2.77817966
50Abnormality of complement system (HP:0005339)2.73925435
51Potter facies (HP:0002009)2.68426312
52Facial shape deformation (HP:0011334)2.68426312
53Lethargy (HP:0001254)2.66866095
54Cardiovascular calcification (HP:0011915)2.64716455
55Hypokalemic alkalosis (HP:0001949)2.61486902
56Generalized aminoaciduria (HP:0002909)2.58323073
57Proximal tubulopathy (HP:0000114)2.57979812
58Increased purine levels (HP:0004368)2.56425902
59Hyperuricemia (HP:0002149)2.56425902
60Hepatocellular carcinoma (HP:0001402)2.54008684
61Metabolic alkalosis (HP:0200114)2.53784136
62Increased circulating renin level (HP:0000848)2.53429597
63Malnutrition (HP:0004395)2.53329341
64Rickets (HP:0002748)2.53322208
65Abnormality of renin-angiotensin system (HP:0000847)2.52537675
66Irritability (HP:0000737)2.49903721
67Glycosuria (HP:0003076)2.49612861
68Abnormality of urine glucose concentration (HP:0011016)2.49612861
69Enlarged kidneys (HP:0000105)2.47716627
70Cerebral edema (HP:0002181)2.45413124
71Recurrent gram-negative bacterial infections (HP:0005420)2.39870951
72Hypoglycemic seizures (HP:0002173)2.39798577
73Hypertriglyceridemia (HP:0002155)2.39718620
74Hyperaldosteronism (HP:0000859)2.37559391
75Vomiting (HP:0002013)2.35646656
76Spastic paraparesis (HP:0002313)2.34127270
77Sensorimotor neuropathy (HP:0007141)2.32213134
78Increased serum pyruvate (HP:0003542)2.26852277
79Abnormality of proline metabolism (HP:0010907)2.23722996
80Hydroxyprolinuria (HP:0003080)2.23722996
81Hypophosphatemic rickets (HP:0004912)2.20284142
82Abnormal gallbladder morphology (HP:0012437)2.20082943
83Acanthocytosis (HP:0001927)2.19542595
84Abnormal gallbladder physiology (HP:0012438)2.19219915
85Cholecystitis (HP:0001082)2.19219915
86Hyperactive renin-angiotensin system (HP:0000841)2.19051849
87Abnormality of glycolysis (HP:0004366)2.17651031
88Abnormal enzyme/coenzyme activity (HP:0012379)2.14747944
89Gingival bleeding (HP:0000225)2.14460538
90Spontaneous abortion (HP:0005268)2.14189682
91Abnormality of carpal bone ossification (HP:0006257)2.10788386
92Confusion (HP:0001289)2.09958572
93Myocardial infarction (HP:0001658)2.09275828
94Neonatal onset (HP:0003623)2.07783967
95Abnormality of vitamin metabolism (HP:0100508)2.07729875
96Hyperphosphaturia (HP:0003109)2.07111698
97Skin nodule (HP:0200036)2.05968090
98Focal segmental glomerulosclerosis (HP:0000097)2.05073291
99Systemic lupus erythematosus (HP:0002725)2.04936960
100Opisthotonus (HP:0002179)2.04881649
101Hypomagnesemia (HP:0002917)2.04867581
102Brushfield spots (HP:0001088)2.04258190
103Hypochromic microcytic anemia (HP:0004840)2.04038844
104Pancreatitis (HP:0001733)2.03259901
105Osteomalacia (HP:0002749)2.03090503
106Cholelithiasis (HP:0001081)2.02929442
107Spastic diplegia (HP:0001264)2.01082087
108Nausea (HP:0002018)2.00277268
109Amyloidosis (HP:0011034)1.99332984
110Neurofibrillary tangles (HP:0002185)1.98658929
111Abnormal tarsal ossification (HP:0008369)1.98526728
112Hyperinsulinemic hypoglycemia (HP:0000825)1.97775867
113Mitral stenosis (HP:0001718)1.96555196
114Abnormal urine output (HP:0012590)1.96118633
115Late onset (HP:0003584)1.95794829
116Abnormality of chloride homeostasis (HP:0011422)1.95044332
117Hypokalemia (HP:0002900)1.94369880
118Abnormality of alkaline phosphatase activity (HP:0004379)1.93726839
119Renal tubular acidosis (HP:0001947)1.92051203
120Ileus (HP:0002595)1.90988799
121Flat acetabular roof (HP:0003180)1.90459416
122Abdominal distention (HP:0003270)1.89843412
123Hypophosphatemia (HP:0002148)1.88014867
124Menorrhagia (HP:0000132)1.87892177
125Abnormality of magnesium homeostasis (HP:0004921)1.81158298
126Abnormal urine phosphate concentration (HP:0012599)1.79360853
127Glomerulosclerosis (HP:0000096)1.76269766
128Acanthosis nigricans (HP:0000956)1.74496313
129Elevated alkaline phosphatase (HP:0003155)1.74319817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.13764005
2OXSR14.96142890
3STK394.84010221
4WNK44.26185703
5LMTK23.61963099
6WNK33.21303522
7RIPK13.19406340
8EPHA22.80949353
9FGFR42.72816386
10SIK12.57105131
11EPHB12.53381826
12INSRR2.49824887
13ERBB42.37215336
14TRIB32.24940038
15MET2.13772788
16ACVR1B2.13096333
17PKN12.00187756
18ERN11.93446923
19TAOK31.87088522
20FGFR31.86322142
21MST1R1.78902239
22FGFR21.70004286
23EPHB21.67382326
24MAPK151.62694097
25PBK1.57591466
26TBK11.46976802
27PRKG21.46616914
28PIK3CG1.35329757
29SGK2231.30225583
30SGK4941.30225583
31ABL21.26537250
32WNK11.24693706
33MST41.24359458
34BCR1.22101460
35DDR21.19959802
36CAMK1D1.17144918
37BMX1.15443157
38RET1.15101644
39ICK1.14736199
40FER1.12519538
41CSNK1G11.11980918
42CSNK1G31.10315391
43MAPK111.06803780
44NLK1.05482875
45IRAK31.02786949
46PINK10.99562047
47CSNK1A1L0.99330674
48MYLK0.98867245
49CAMK2G0.96767651
50TAOK20.95759796
51MAP3K10.89352539
52PRKCQ0.86932625
53KSR20.86666413
54PDGFRA0.86632276
55IKBKE0.86460131
56MAP2K40.85352403
57IRAK20.85159546
58PRKAA20.82862856
59GRK60.82211109
60CSNK1G20.81953672
61GSK3A0.80901601
62TNIK0.80696251
63MAP2K10.78776845
64LATS10.78161123
65STK240.77243718
66TESK20.76817851
67PTK60.76657114
68KDR0.75599155
69TIE10.75269393
70NTRK10.73391765
71IRAK10.71926414
72CAMK10.71652682
73NEK60.71132172
74PTK20.70577355
75MAP3K70.70566887
76EPHA40.70382561
77NTRK30.69815550
78TESK10.69115038
79CAMK2B0.68091612
80CAMK1G0.67937489
81CSK0.67497197
82MAPKAPK30.66979650
83STK38L0.66248087
84PRKCZ0.63095938
85MAP2K60.62316964
86FGFR10.61305034
87MAP3K120.60701664
88PDGFRB0.60659654
89CDC42BPA0.57989832
90MTOR0.57722524
91JAK20.57668777
92PAK30.57413509
93YES10.55419918
94PRKACG0.55108908
95STK380.54983543
96MAP3K30.54906625
97CAMK2D0.54878210
98FRK0.54109834
99DYRK1B0.53186588
100* PDPK10.52871733
101MAP2K20.52847733
102ERBB20.50530025
103MAPK70.50343605
104PRKCE0.48644340
105FLT30.47499548
106PRKAA10.47394885
107CSF1R0.47313716
108MAPK40.47120885
109DAPK20.46530975
110PIK3CA0.45576702
111GRK10.44179274
112MAP3K140.43560410
113PRKD10.43041118
114PDK20.42449001
115PKN20.41580005
116STK30.41156528
117CDK60.41118228
118SGK30.41065515
119MAPK120.40831187
120MAP3K20.40341845
121SRC0.39434293
122ROCK20.39338081
123TYK20.37431614
124LATS20.36338857
125IGF1R0.35821118
126FGR0.35716384
127MARK20.35410094
128CDK90.34967828
129CAMK2A0.34694903
130STK160.34608401
131PRKCA0.33867947
132TAOK10.32910497
133JAK10.32239568
134TYRO30.31625525
135PRKCG0.29795077
136PRKACA0.29770186
137UHMK10.27126699
138ITK0.24880605
139PRKACB0.24835000
140ARAF0.24262286
141EPHA30.23265609
142SGK20.22718855
143PRKG10.21707035
144ABL10.21532736
145PRKCH0.21278979

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.87474746
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.21780582
3Nitrogen metabolism_Homo sapiens_hsa009103.02273169
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.79724583
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78093845
6Butanoate metabolism_Homo sapiens_hsa006502.63910718
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63761400
8Tryptophan metabolism_Homo sapiens_hsa003802.63424083
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63189018
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.61783725
11Arginine biosynthesis_Homo sapiens_hsa002202.53960160
12Fatty acid degradation_Homo sapiens_hsa000712.44812843
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44284309
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24324872
15Peroxisome_Homo sapiens_hsa041462.22191254
16Propanoate metabolism_Homo sapiens_hsa006402.19783998
17Complement and coagulation cascades_Homo sapiens_hsa046102.12423203
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12202488
19Histidine metabolism_Homo sapiens_hsa003402.10248882
20Steroid biosynthesis_Homo sapiens_hsa001002.03782158
21Sulfur metabolism_Homo sapiens_hsa009201.98680540
22Fatty acid elongation_Homo sapiens_hsa000621.94467697
23Fatty acid metabolism_Homo sapiens_hsa012121.92408769
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.81179632
25Chemical carcinogenesis_Homo sapiens_hsa052041.78745133
26beta-Alanine metabolism_Homo sapiens_hsa004101.78070270
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77680009
28PPAR signaling pathway_Homo sapiens_hsa033201.74323713
29Retinol metabolism_Homo sapiens_hsa008301.58525997
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58432053
31Pyruvate metabolism_Homo sapiens_hsa006201.54622223
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53042884
33Bile secretion_Homo sapiens_hsa049761.52198894
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51517521
35Phenylalanine metabolism_Homo sapiens_hsa003601.48447456
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.43423052
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42621647
38Tyrosine metabolism_Homo sapiens_hsa003501.34838972
39Caffeine metabolism_Homo sapiens_hsa002321.31694167
40Folate biosynthesis_Homo sapiens_hsa007901.30885447
41Selenocompound metabolism_Homo sapiens_hsa004501.30267640
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25158599
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.24643618
44Vitamin digestion and absorption_Homo sapiens_hsa049771.21725209
45Arginine and proline metabolism_Homo sapiens_hsa003301.21569225
46Staphylococcus aureus infection_Homo sapiens_hsa051501.20894514
47Starch and sucrose metabolism_Homo sapiens_hsa005001.19499796
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.14729322
49ABC transporters_Homo sapiens_hsa020101.14338513
50Fat digestion and absorption_Homo sapiens_hsa049751.13669085
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.11841142
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11513491
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08746624
54Carbon metabolism_Homo sapiens_hsa012001.07345144
55Vitamin B6 metabolism_Homo sapiens_hsa007500.99074345
56Biosynthesis of amino acids_Homo sapiens_hsa012300.98963637
57Glutathione metabolism_Homo sapiens_hsa004800.95361062
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86449571
59Sulfur relay system_Homo sapiens_hsa041220.79465182
60Glycerolipid metabolism_Homo sapiens_hsa005610.77611118
61Lysine degradation_Homo sapiens_hsa003100.77053817
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69537754
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64024419
64Metabolic pathways_Homo sapiens_hsa011000.56894354
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54769664
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50451006
67Pentose phosphate pathway_Homo sapiens_hsa000300.49056665
68Linoleic acid metabolism_Homo sapiens_hsa005910.46854527
69Fatty acid biosynthesis_Homo sapiens_hsa000610.46808727
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39457595
71One carbon pool by folate_Homo sapiens_hsa006700.32431422
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31906106
73Ether lipid metabolism_Homo sapiens_hsa005650.31328160
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.26920020
75Mineral absorption_Homo sapiens_hsa049780.25349444
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.23931861
77Fructose and mannose metabolism_Homo sapiens_hsa000510.22509006
78Prion diseases_Homo sapiens_hsa050200.21734470
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20622223
80Pancreatic secretion_Homo sapiens_hsa049720.16172241
81Pertussis_Homo sapiens_hsa051330.14440956
82Galactose metabolism_Homo sapiens_hsa000520.13023052
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12992351
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12538509
85Oxidative phosphorylation_Homo sapiens_hsa001900.12333650
86Arachidonic acid metabolism_Homo sapiens_hsa005900.11935055
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.11117151
88Insulin signaling pathway_Homo sapiens_hsa049100.10657543
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08783529
90Insulin resistance_Homo sapiens_hsa049310.05462917
91Renin secretion_Homo sapiens_hsa049240.04124777
92Ovarian steroidogenesis_Homo sapiens_hsa049130.01780104
93Protein digestion and absorption_Homo sapiens_hsa049740.01386944
94Protein export_Homo sapiens_hsa03060-0.1280786
95Hepatitis C_Homo sapiens_hsa05160-0.1258391
96Other glycan degradation_Homo sapiens_hsa00511-0.1253251
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1229718
98Glucagon signaling pathway_Homo sapiens_hsa04922-0.1133989
99Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0999373
100Alzheimers disease_Homo sapiens_hsa05010-0.0899202
101Parkinsons disease_Homo sapiens_hsa05012-0.0881617
102Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0737989
103Lysosome_Homo sapiens_hsa04142-0.0699848
104Collecting duct acid secretion_Homo sapiens_hsa04966-0.0689192
105AMPK signaling pathway_Homo sapiens_hsa04152-0.0652938
106Renin-angiotensin system_Homo sapiens_hsa04614-0.0540456
107Regulation of autophagy_Homo sapiens_hsa04140-0.0533257
108Serotonergic synapse_Homo sapiens_hsa04726-0.0430555
109Insulin secretion_Homo sapiens_hsa04911-0.0336467
110Sphingolipid metabolism_Homo sapiens_hsa00600-0.0253183
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0084296

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