SGIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 17626015]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.49669420
2central nervous system myelination (GO:0022010)9.49669420
3fatty acid elongation (GO:0030497)6.21917959
4synaptic vesicle maturation (GO:0016188)5.60291746
5long-chain fatty acid biosynthetic process (GO:0042759)5.52386077
6myelination (GO:0042552)5.38988236
7ensheathment of neurons (GO:0007272)5.34082767
8axon ensheathment (GO:0008366)5.34082767
9glutamate secretion (GO:0014047)5.28879176
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.12606924
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.91662511
12presynaptic membrane organization (GO:0097090)4.65952092
13presynaptic membrane assembly (GO:0097105)4.63477711
14negative regulation of neurotransmitter transport (GO:0051589)4.58803196
15neuron cell-cell adhesion (GO:0007158)4.49754079
16L-amino acid import (GO:0043092)4.35888337
17negative regulation of neurotransmitter secretion (GO:0046929)4.32353112
18neurotransmitter secretion (GO:0007269)4.18060162
19regulation of synaptic vesicle transport (GO:1902803)3.97207292
20neurotransmitter-gated ion channel clustering (GO:0072578)3.94758998
21establishment of mitochondrion localization (GO:0051654)3.90110066
22pyrimidine nucleobase catabolic process (GO:0006208)3.84185281
23cellular potassium ion homeostasis (GO:0030007)3.83940807
24negative regulation of protein localization to cell surface (GO:2000009)3.81560645
25regulation of collateral sprouting (GO:0048670)3.74347943
26neuronal action potential propagation (GO:0019227)3.74169068
27photoreceptor cell differentiation (GO:0046530)3.73219337
28eye photoreceptor cell differentiation (GO:0001754)3.73219337
29membrane depolarization during action potential (GO:0086010)3.73106640
30exploration behavior (GO:0035640)3.66186865
31oligodendrocyte differentiation (GO:0048709)3.65882759
32glycerophospholipid catabolic process (GO:0046475)3.63549884
33transmission of nerve impulse (GO:0019226)3.60390254
34locomotory exploration behavior (GO:0035641)3.60268685
35response to methylmercury (GO:0051597)3.58663401
36positive regulation of synapse maturation (GO:0090129)3.53503731
37regulation of synapse structural plasticity (GO:0051823)3.53492214
38negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.46766527
39myelin maintenance (GO:0043217)3.44873348
40cholesterol biosynthetic process (GO:0006695)3.43082158
41positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.41390764
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.40788208
43sodium ion export (GO:0071436)3.38750991
44amino acid import (GO:0043090)3.35495561
45adult walking behavior (GO:0007628)3.34998198
46regulation of neuronal synaptic plasticity (GO:0048168)3.33149783
47proline transport (GO:0015824)3.33128170
48neurotransmitter transport (GO:0006836)3.30954892
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.24432343
50synapse assembly (GO:0007416)3.24164747
51nucleobase catabolic process (GO:0046113)3.23425004
52response to redox state (GO:0051775)3.22386623
53cerebral cortex radially oriented cell migration (GO:0021799)3.22080263
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21336795
55positive regulation of action potential (GO:0045760)3.20861208
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20706046
57import into cell (GO:0098657)3.17490022
58apical protein localization (GO:0045176)3.17407388
59positive regulation of oligodendrocyte differentiation (GO:0048714)3.17204178
60gamma-aminobutyric acid signaling pathway (GO:0007214)3.17156219
61neurotransmitter uptake (GO:0001504)3.16602648
62asymmetric protein localization (GO:0008105)3.15607318
63membrane depolarization (GO:0051899)3.15370839
64regulation of neurotransmitter levels (GO:0001505)3.14620208
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.14458494
66regulation of vesicle fusion (GO:0031338)3.12654409
67regulation of postsynaptic membrane potential (GO:0060078)3.11685187
68neuron remodeling (GO:0016322)3.11019924
69layer formation in cerebral cortex (GO:0021819)3.10710486
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.10670323
71positive regulation of membrane potential (GO:0045838)3.10557597
72regulation of glutamate receptor signaling pathway (GO:1900449)3.10117874
73central nervous system projection neuron axonogenesis (GO:0021952)3.10050828
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.09551304
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.09419830
76dendrite morphogenesis (GO:0048813)3.08968471
77cerebellar Purkinje cell differentiation (GO:0021702)3.08791432
78neuron recognition (GO:0008038)3.08322984
79ionotropic glutamate receptor signaling pathway (GO:0035235)3.08055174
80substantia nigra development (GO:0021762)3.07484241
81limb bud formation (GO:0060174)3.07208865
82sterol biosynthetic process (GO:0016126)3.06543108
83negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05645445
84positive regulation of dendritic spine development (GO:0060999)3.04953939
85response to auditory stimulus (GO:0010996)3.04215528
86synaptic vesicle endocytosis (GO:0048488)3.03153122
87regulation of neurotransmitter secretion (GO:0046928)3.02223005
88amyloid precursor protein metabolic process (GO:0042982)3.01034026
89isoprenoid biosynthetic process (GO:0008299)3.00109103
90cell migration in hindbrain (GO:0021535)2.99625412
91regulation of synapse maturation (GO:0090128)2.98423891
92astrocyte development (GO:0014002)2.98387861
93neuronal action potential (GO:0019228)2.97587469
94protein localization to synapse (GO:0035418)2.93688441
95GPI anchor biosynthetic process (GO:0006506)2.93078472
96urinary tract smooth muscle contraction (GO:0014848)2.93004134
97neuromuscular synaptic transmission (GO:0007274)2.92015471
98regulation of dendritic spine morphogenesis (GO:0061001)2.91467290
99magnesium ion transport (GO:0015693)2.91144002
100glutamate receptor signaling pathway (GO:0007215)2.89436840
101dendritic spine morphogenesis (GO:0060997)2.89141944
102GPI anchor metabolic process (GO:0006505)2.87021702
103negative regulation of cytosolic calcium ion concentration (GO:0051481)2.86698695
104protein palmitoylation (GO:0018345)2.85202904
105synaptic transmission (GO:0007268)2.85036875
106G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84962376
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.84701324
108serotonin metabolic process (GO:0042428)2.84441374
109positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.84235494
110regulation of dendritic spine development (GO:0060998)2.83973444
111long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.83051241
112regulation of neurotransmitter transport (GO:0051588)2.82833970
113long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.82782497
114regulation of synapse assembly (GO:0051963)2.82240110
115neurofilament cytoskeleton organization (GO:0060052)2.81377316
116synapse organization (GO:0050808)2.79212371
117negative regulation of axonogenesis (GO:0050771)2.77444674
118regulation of short-term neuronal synaptic plasticity (GO:0048172)2.75784736
119cell communication by electrical coupling (GO:0010644)2.75580602
120peptidyl-tyrosine autophosphorylation (GO:0038083)2.75065311
121neuronal ion channel clustering (GO:0045161)2.75008444
122regulation of catecholamine metabolic process (GO:0042069)2.74682546
123regulation of dopamine metabolic process (GO:0042053)2.74682546
124axon development (GO:0061564)2.73595798
125regulation of synaptic transmission, GABAergic (GO:0032228)2.73253217
126long-term memory (GO:0007616)2.72086813
127cellular response to epinephrine stimulus (GO:0071872)2.70891192
128neuron-neuron synaptic transmission (GO:0007270)2.70504817
129regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.70171530
130C4-dicarboxylate transport (GO:0015740)2.69452518
131synaptic transmission, glutamatergic (GO:0035249)2.68261197
132preassembly of GPI anchor in ER membrane (GO:0016254)2.68075320
133synaptic vesicle exocytosis (GO:0016079)2.64330581
134mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.62958961
135nerve growth factor signaling pathway (GO:0038180)2.62513753
136response to epinephrine (GO:0071871)2.62397412
137axonal fasciculation (GO:0007413)2.62176719
138regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.60735401
139positive regulation of synapse assembly (GO:0051965)2.60462987
140startle response (GO:0001964)2.60022343
141membrane assembly (GO:0071709)2.59959008
142regulation of voltage-gated calcium channel activity (GO:1901385)2.58877670
143protein neddylation (GO:0045116)2.58856310
144postsynaptic membrane organization (GO:0001941)2.57672130
145gamma-aminobutyric acid transport (GO:0015812)2.55526825
146creatine metabolic process (GO:0006600)2.55323963
147mechanosensory behavior (GO:0007638)2.53415978
148cerebellar granule cell differentiation (GO:0021707)2.51166533
149vocalization behavior (GO:0071625)2.50335940
150cranial nerve development (GO:0021545)2.50224640
151negative regulation of axon extension (GO:0030517)2.48108552
152dopamine biosynthetic process (GO:0042416)2.47913043
153positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47664097
154adult locomotory behavior (GO:0008344)2.47604471
155negative regulation of synaptic transmission (GO:0050805)2.45904745
156peripheral nervous system development (GO:0007422)2.45651174
157detection of temperature stimulus involved in sensory perception (GO:0050961)2.44112539
158detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.44112539
159positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.41268149
160mating behavior (GO:0007617)2.40638938
161auditory behavior (GO:0031223)2.40381525
162regulation of synaptic vesicle exocytosis (GO:2000300)2.39484385
163myelination in peripheral nervous system (GO:0022011)2.39346342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.07478789
2GBX2_23144817_ChIP-Seq_PC3_Human3.85183119
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.94881566
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71184268
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70648974
6TAF15_26573619_Chip-Seq_HEK293_Human2.67477492
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59772515
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.40336015
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29597963
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24023828
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.23873861
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22803729
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22803729
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19777457
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17133992
16SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.16186668
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13353160
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13121185
19AR_21572438_ChIP-Seq_LNCaP_Human2.08025700
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05021313
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02942102
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.99145069
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98834438
24VDR_22108803_ChIP-Seq_LS180_Human1.94837564
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94126193
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91152189
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87192146
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86230835
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83917015
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.83878047
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.82305949
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80727596
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77628189
34ER_23166858_ChIP-Seq_MCF-7_Human1.73064836
35DROSHA_22980978_ChIP-Seq_HELA_Human1.68219702
36REST_21632747_ChIP-Seq_MESCs_Mouse1.67214854
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67039648
38* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65137946
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.62911616
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62851391
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60956414
42P300_19829295_ChIP-Seq_ESCs_Human1.60741187
43FUS_26573619_Chip-Seq_HEK293_Human1.60700976
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57680676
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57481430
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56595070
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.54157375
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40634230
49SMAD4_21799915_ChIP-Seq_A2780_Human1.40612101
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39456164
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.36692206
52IGF1R_20145208_ChIP-Seq_DFB_Human1.35837629
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.33662923
54* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31158373
55RNF2_27304074_Chip-Seq_NSC_Mouse1.31111512
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30307905
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27815800
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.26696476
59* NANOG_18555785_Chip-Seq_ESCs_Mouse1.22904906
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22066837
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21854364
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21447606
63* STAT3_23295773_ChIP-Seq_U87_Human1.19213234
64* TP53_18474530_ChIP-ChIP_U2OS_Human1.18803228
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17431394
66STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17248831
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.15319233
68* AR_19668381_ChIP-Seq_PC3_Human1.14083250
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12430343
70* PRDM14_20953172_ChIP-Seq_ESCs_Human1.12307955
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10516226
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10461837
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10247993
74* TCF4_23295773_ChIP-Seq_U87_Human1.09912210
75* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09084799
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08842218
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08453724
78* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08168959
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.08020412
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07259021
81* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06553594
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06506839
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05551015
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04812523
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04389908
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04082732
87P300_18555785_Chip-Seq_ESCs_Mouse1.04027855
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.03846659
89* JUN_21703547_ChIP-Seq_K562_Human1.03113763
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.03050312
91CBP_20019798_ChIP-Seq_JUKART_Human1.02937129
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02937129
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02830217
94RUNX2_22187159_ChIP-Seq_PCA_Human1.02011820
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01938511
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01906633
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01906633
98P53_22387025_ChIP-Seq_ESCs_Mouse1.01820523
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.01781040
100WT1_19549856_ChIP-ChIP_CCG9911_Human1.00605780
101AR_25329375_ChIP-Seq_VCAP_Human1.00539859
102* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00126150
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00089857
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99905706
105EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99244903
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.99052958
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99051878
108LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98917959
109IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98744693
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98635955
111AHR_22903824_ChIP-Seq_MCF-7_Human0.97682166
112RING1B_27294783_Chip-Seq_ESCs_Mouse0.96846957
113EWS_26573619_Chip-Seq_HEK293_Human0.96714648
114ZNF274_21170338_ChIP-Seq_K562_Hela0.95836630
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.95369262
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94736314
117TP53_16413492_ChIP-PET_HCT116_Human0.94236388
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93621387
119* KDM2B_26808549_Chip-Seq_REH_Human0.92822412
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92536036
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92414993
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92414993
123STAT3_18555785_Chip-Seq_ESCs_Mouse0.91761655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.87302304
2MP0000920_abnormal_myelination3.79535537
3MP0004270_analgesia3.38656503
4MP0004859_abnormal_synaptic_plasticity3.10968013
5MP0005423_abnormal_somatic_nervous2.89085544
6MP0002272_abnormal_nervous_system2.72412004
7MP0001486_abnormal_startle_reflex2.70690138
8MP0005171_absent_coat_pigmentation2.69662894
9MP0002064_seizures2.64355743
10MP0001529_abnormal_vocalization2.60571864
11MP0003635_abnormal_synaptic_transmissio2.57703680
12MP0003136_yellow_coat_color2.50062284
13MP0009745_abnormal_behavioral_response2.45344216
14MP0003950_abnormal_plasma_membrane2.45137148
15MP0009046_muscle_twitch2.42152897
16MP0001905_abnormal_dopamine_level2.38146861
17MP0005409_darkened_coat_color2.33791150
18MP0004742_abnormal_vestibular_system2.32867063
19MP0003690_abnormal_glial_cell2.19308748
20MP0003329_amyloid_beta_deposits2.17289407
21MP0002734_abnormal_mechanical_nocicepti2.15017947
22MP0005551_abnormal_eye_electrophysiolog2.14977036
23MP0004885_abnormal_endolymph2.13647584
24MP0000778_abnormal_nervous_system2.08257209
25MP0004142_abnormal_muscle_tone2.07131925
26MP0002572_abnormal_emotion/affect_behav2.04119593
27MP0002063_abnormal_learning/memory/cond1.95298533
28MP0003787_abnormal_imprinting1.90081263
29MP0001968_abnormal_touch/_nociception1.85066994
30MP0000569_abnormal_digit_pigmentation1.83060295
31MP0001440_abnormal_grooming_behavior1.76927845
32MP0001485_abnormal_pinna_reflex1.76791413
33MP0003634_abnormal_glial_cell1.72760987
34MP0002229_neurodegeneration1.71907842
35MP0001970_abnormal_pain_threshold1.66550086
36MP0002067_abnormal_sensory_capabilities1.64661783
37MP0003122_maternal_imprinting1.60776369
38MP0004381_abnormal_hair_follicle1.59471459
39MP0002735_abnormal_chemical_nociception1.58584709
40MP0003879_abnormal_hair_cell1.54483318
41MP0002882_abnormal_neuron_morphology1.48982538
42MP0002736_abnormal_nociception_after1.47623182
43MP0008569_lethality_at_weaning1.47007805
44MP0002733_abnormal_thermal_nociception1.45246398
45MP0006072_abnormal_retinal_apoptosis1.44615376
46MP0005410_abnormal_fertilization1.43440198
47MP0000955_abnormal_spinal_cord1.41783454
48MP0002822_catalepsy1.41706684
49MP0001501_abnormal_sleep_pattern1.40495385
50MP0004924_abnormal_behavior1.40401999
51MP0005386_behavior/neurological_phenoty1.40401999
52MP0009780_abnormal_chondrocyte_physiolo1.39394547
53MP0003632_abnormal_nervous_system1.39193281
54MP0001963_abnormal_hearing_physiology1.32507018
55MP0002752_abnormal_somatic_nervous1.29760241
56MP0002066_abnormal_motor_capabilities/c1.29496537
57MP0003631_nervous_system_phenotype1.29064107
58MP0005253_abnormal_eye_physiology1.28599730
59MP0006276_abnormal_autonomic_nervous1.26643577
60MP0001188_hyperpigmentation1.26432728
61MP0002184_abnormal_innervation1.25239616
62MP0000372_irregular_coat_pigmentation1.24770474
63MP0003633_abnormal_nervous_system1.23631880
64MP0005645_abnormal_hypothalamus_physiol1.22351478
65MP0004043_abnormal_pH_regulation1.18336496
66MP0002557_abnormal_social/conspecific_i1.17430075
67MP0005503_abnormal_tendon_morphology1.16453200
68MP0005187_abnormal_penis_morphology1.13744316
69MP0003938_abnormal_ear_development1.09036971
70MP0005195_abnormal_posterior_eye1.08749284
71MP0000462_abnormal_digestive_system1.07184797
72MP0004145_abnormal_muscle_electrophysio1.04402345
73MP0001986_abnormal_taste_sensitivity1.04236371
74MP0001502_abnormal_circadian_rhythm1.02969606
75MP0000026_abnormal_inner_ear1.02736616
76MP0005646_abnormal_pituitary_gland0.99893635
77MP0008877_abnormal_DNA_methylation0.98403321
78MP0002638_abnormal_pupillary_reflex0.97925358
79MP0010678_abnormal_skin_adnexa0.95910637
80MP0001984_abnormal_olfaction0.94410776
81MP0000604_amyloidosis0.92753320
82MP0002152_abnormal_brain_morphology0.92591394
83MP0003121_genomic_imprinting0.92582740
84MP0002102_abnormal_ear_morphology0.91482834
85MP0000383_abnormal_hair_follicle0.90842030
86MP0000631_abnormal_neuroendocrine_gland0.90469136
87MP0004147_increased_porphyrin_level0.87181663
88MP0000566_synostosis0.87059962
89MP0001661_extended_life_span0.86643504
90MP0002909_abnormal_adrenal_gland0.86629391
91MP0003283_abnormal_digestive_organ0.86434676
92MP0008260_abnormal_autophagy0.85992759
93MP0002090_abnormal_vision0.85615013
94MP0001299_abnormal_eye_distance/0.85218929
95MP0004085_abnormal_heartbeat0.81647987
96MP0001346_abnormal_lacrimal_gland0.80401021
97MP0000751_myopathy0.80122546
98MP0004134_abnormal_chest_morphology0.79185323
99MP0002069_abnormal_eating/drinking_beha0.78543571
100MP0002751_abnormal_autonomic_nervous0.78086739
101MP0004811_abnormal_neuron_physiology0.77264402
102MP0000534_abnormal_ureter_morphology0.75445488
103MP0004215_abnormal_myocardial_fiber0.74984710
104MP0001177_atelectasis0.74082825
105MP0005451_abnormal_body_composition0.69505712
106MP0010386_abnormal_urinary_bladder0.68904569
107MP0004133_heterotaxia0.68453708
108MP0003861_abnormal_nervous_system0.66277604
109MP0000049_abnormal_middle_ear0.64581350
110MP0001664_abnormal_digestion0.63790692
111MP0004130_abnormal_muscle_cell0.62373816
112MP0003011_delayed_dark_adaptation0.61421319
113MP0001943_abnormal_respiration0.60959831
114MP0000647_abnormal_sebaceous_gland0.60895028
115MP0003137_abnormal_impulse_conducting0.60620374
116MP0000762_abnormal_tongue_morphology0.60531633
117MP0000747_muscle_weakness0.60083003
118MP0000013_abnormal_adipose_tissue0.59787947
119MP0002234_abnormal_pharynx_morphology0.59115928
120MP0005623_abnormal_meninges_morphology0.58605851
121MP0005408_hypopigmentation0.58247925
122MP0010770_preweaning_lethality0.57815741
123MP0002082_postnatal_lethality0.57815741
124MP0003045_fibrosis0.57628075
125MP0002938_white_spotting0.56895127
126MP0010769_abnormal_survival0.56814524
127MP0003937_abnormal_limbs/digits/tail_de0.55097378
128MP0005595_abnormal_vascular_smooth0.54673697
129MP0006292_abnormal_olfactory_placode0.54189543

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.59638754
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.59638754
3Neurofibrillary tangles (HP:0002185)5.35590311
4Parakeratosis (HP:0001036)4.40607474
5Abnormality of the corticospinal tract (HP:0002492)4.33467465
6Peripheral hypomyelination (HP:0007182)4.31242476
7Limb dystonia (HP:0002451)4.17155112
8Focal motor seizures (HP:0011153)3.90309384
9Cerebral inclusion bodies (HP:0100314)3.84348267
10Sensory axonal neuropathy (HP:0003390)3.61682363
11Supranuclear gaze palsy (HP:0000605)3.58010360
12Myokymia (HP:0002411)3.54889067
13Drooling (HP:0002307)3.39725374
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.34157412
15Retinal dysplasia (HP:0007973)3.23640845
16Epileptiform EEG discharges (HP:0011182)3.22085474
17Abnormal eating behavior (HP:0100738)3.14309182
18Excessive salivation (HP:0003781)3.10732783
19Spastic gait (HP:0002064)3.06284295
20Absent speech (HP:0001344)3.06165018
21Insidious onset (HP:0003587)3.00960638
22Termporal pattern (HP:0011008)3.00960638
23Dysmetria (HP:0001310)2.99694590
24EEG with generalized epileptiform discharges (HP:0011198)2.98894657
25Torticollis (HP:0000473)2.92332377
26Onion bulb formation (HP:0003383)2.90531311
27Epileptic encephalopathy (HP:0200134)2.87609861
28Hypsarrhythmia (HP:0002521)2.81358585
29Genetic anticipation (HP:0003743)2.79584383
30Scanning speech (HP:0002168)2.77012397
31Polyphagia (HP:0002591)2.74473624
32Urinary urgency (HP:0000012)2.72893189
33Alacrima (HP:0000522)2.72352395
34Focal seizures (HP:0007359)2.70622843
35Inability to walk (HP:0002540)2.63306885
36Urinary bladder sphincter dysfunction (HP:0002839)2.56328834
37Atonic seizures (HP:0010819)2.54187582
38Mutism (HP:0002300)2.51036579
39Status epilepticus (HP:0002133)2.47053974
40Intention tremor (HP:0002080)2.46279857
41Amblyopia (HP:0000646)2.45197060
42Ankle clonus (HP:0011448)2.43790185
43Thickened helices (HP:0000391)2.43468710
44Amyotrophic lateral sclerosis (HP:0007354)2.42279802
45Abnormal auditory evoked potentials (HP:0006958)2.42134170
46Cerebral hypomyelination (HP:0006808)2.40991511
47Absent septum pellucidum (HP:0001331)2.40988601
48Hemiplegia (HP:0002301)2.40859208
49Clumsiness (HP:0002312)2.40253164
50Anteriorly placed anus (HP:0001545)2.40019609
51Increased serum pyruvate (HP:0003542)2.39550417
52Abnormality of glycolysis (HP:0004366)2.39550417
53Poor eye contact (HP:0000817)2.39335183
54Renal Fanconi syndrome (HP:0001994)2.38022400
55Impaired vibration sensation in the lower limbs (HP:0002166)2.37894954
56Leukodystrophy (HP:0002415)2.36875409
57Slow saccadic eye movements (HP:0000514)2.35749697
58Postural instability (HP:0002172)2.35477349
59Papilledema (HP:0001085)2.34151244
60Broad-based gait (HP:0002136)2.33940732
61Vaginal atresia (HP:0000148)2.33748068
62Progressive cerebellar ataxia (HP:0002073)2.33371784
63Abnormality of the lower motor neuron (HP:0002366)2.32621765
64Akinesia (HP:0002304)2.32241941
65White forelock (HP:0002211)2.29002438
66Genital tract atresia (HP:0001827)2.27023378
67Increased circulating renin level (HP:0000848)2.26408059
68Patchy hypopigmentation of hair (HP:0011365)2.26210447
69Spastic tetraplegia (HP:0002510)2.25955640
70Congenital ichthyosiform erythroderma (HP:0007431)2.25058536
71Cupped ear (HP:0000378)2.23460624
72Dialeptic seizures (HP:0011146)2.22729156
73Split foot (HP:0001839)2.20470190
74Focal dystonia (HP:0004373)2.20078221
75Hyperventilation (HP:0002883)2.19904159
76Decreased lacrimation (HP:0000633)2.18405271
77Protruding tongue (HP:0010808)2.17066692
78Hypoplastic pelvis (HP:0008839)2.16981430
79Acute necrotizing encephalopathy (HP:0006965)2.16822387
80Hypoventilation (HP:0002791)2.16791549
81Hemiparesis (HP:0001269)2.15736331
82Metabolic alkalosis (HP:0200114)2.15212709
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13025041
84Aplasia involving bones of the extremities (HP:0009825)2.12811649
85Aplasia involving bones of the upper limbs (HP:0009823)2.12811649
86Aplasia of the phalanges of the hand (HP:0009802)2.12811649
87Abnormality of the septum pellucidum (HP:0007375)2.11799220
88Synostosis involving the elbow (HP:0003938)2.10366453
89Humeroradial synostosis (HP:0003041)2.10366453
90Absent/shortened dynein arms (HP:0200106)2.10194715
91Dynein arm defect of respiratory motile cilia (HP:0012255)2.10194715
92Pheochromocytoma (HP:0002666)2.09383531
93Gait imbalance (HP:0002141)2.05023107
94Craniofacial dystonia (HP:0012179)2.04146028
95Clonus (HP:0002169)2.04110387
96Impaired smooth pursuit (HP:0007772)2.04070626
97Congenital sensorineural hearing impairment (HP:0008527)2.03638488
98Cerebral hemorrhage (HP:0001342)2.02425490
99Hypomagnesemia (HP:0002917)2.01804038
100Blue irides (HP:0000635)1.99368785
101Neuroendocrine neoplasm (HP:0100634)1.99236848
102Autoamputation (HP:0001218)1.98540707
103Gaze-evoked nystagmus (HP:0000640)1.97420216
104Hypoplasia of the iris (HP:0007676)1.97331962
105Progressive inability to walk (HP:0002505)1.97106845
106Medial flaring of the eyebrow (HP:0010747)1.96434097
107Fetal akinesia sequence (HP:0001989)1.95971952
108Morphological abnormality of the pyramidal tract (HP:0002062)1.94689393
109Action tremor (HP:0002345)1.94543305
110Morphological abnormality of the inner ear (HP:0011390)1.93905323
111Abnormality of salivation (HP:0100755)1.92400153
112Anxiety (HP:0000739)1.92258755
113Lower limb muscle weakness (HP:0007340)1.91841940
114Abnormal social behavior (HP:0012433)1.91650509
115Impaired social interactions (HP:0000735)1.91650509
116Febrile seizures (HP:0002373)1.91519926
117Sleep apnea (HP:0010535)1.91284555
118Ulnar claw (HP:0001178)1.90609048
119Truncal ataxia (HP:0002078)1.89461299
120Megalencephaly (HP:0001355)1.88501859
121Dysdiadochokinesis (HP:0002075)1.87550924
122Widely spaced teeth (HP:0000687)1.87191048
123Absence seizures (HP:0002121)1.85988761
124Visual hallucinations (HP:0002367)1.85980016
125Increased hepatocellular lipid droplets (HP:0006565)1.85442266
126Progressive macrocephaly (HP:0004481)1.84946705
127Congenital stationary night blindness (HP:0007642)1.84826327
128Hypoplasia of the corpus callosum (HP:0002079)1.84525710
129Generalized myoclonic seizures (HP:0002123)1.83995384
130Mitochondrial inheritance (HP:0001427)1.80733087
131Abolished electroretinogram (ERG) (HP:0000550)1.80591125
132Nephrogenic diabetes insipidus (HP:0009806)1.80290840
133Agitation (HP:0000713)1.80073173
134Hypothermia (HP:0002045)1.79988212
135Partial agenesis of the corpus callosum (HP:0001338)1.79658923
136Optic disc pallor (HP:0000543)1.79635006
137Congenital primary aphakia (HP:0007707)1.79443983
138Methylmalonic acidemia (HP:0002912)1.78472412
139Generalized tonic-clonic seizures (HP:0002069)1.78353593
140Abnormality of binocular vision (HP:0011514)1.78298595
141Diplopia (HP:0000651)1.78298595
142Specific learning disability (HP:0001328)1.78091341
143CNS hypomyelination (HP:0003429)1.77997197
144Septo-optic dysplasia (HP:0100842)1.77329303
1453-Methylglutaconic aciduria (HP:0003535)1.77180250
146Prolonged QT interval (HP:0001657)1.76982062
147Lissencephaly (HP:0001339)1.76800960
148Segmental peripheral demyelination/remyelination (HP:0003481)1.76657190
149Esotropia (HP:0000565)1.73837144
150Delusions (HP:0000746)1.73457358
151Abnormality of ocular smooth pursuit (HP:0000617)1.73181604
152Incomplete penetrance (HP:0003829)1.71899918
153Depression (HP:0000716)1.70355985
154Failure to thrive in infancy (HP:0001531)1.67908552
155Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67716215
156Exotropia (HP:0000577)1.67358291
157Spastic tetraparesis (HP:0001285)1.66071138
158Pachygyria (HP:0001302)1.64245319
159Bradykinesia (HP:0002067)1.64094289
160Primary atrial arrhythmia (HP:0001692)1.62187936
161Bradycardia (HP:0001662)1.61524621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.15438807
2OXSR13.81514827
3TNIK3.03243978
4CASK2.49037784
5EPHB12.46514075
6PNCK2.38441084
7MAPKAPK52.36297301
8PKN12.24729407
9EPHA42.20364277
10CDK192.19588652
11BCR2.13833209
12PBK2.10196829
13DAPK22.08552586
14WNK42.01835303
15AKT31.95351307
16SIK21.89561996
17FRK1.81609362
18NTRK31.77141082
19CAMKK21.76915022
20MARK11.72208099
21PINK11.70103344
22NTRK11.66435994
23UHMK11.66109080
24FGFR21.60941058
25CAMK2B1.60287862
26WNK11.59928468
27MET1.50200921
28MST41.44199981
29CAMKK11.43455736
30NEK61.41240563
31CSNK1G31.38231733
32FGR1.36504999
33CAMK2D1.30537452
34MAP2K41.28249642
35CSNK1A1L1.25704499
36BMPR1B1.25530749
37PAK61.25035843
38NTRK21.21001705
39CSNK1G21.19055945
40ROCK21.17663191
41CLK11.17621258
42MUSK1.16796150
43CAMK2A1.12977353
44GRK71.11096176
45TESK21.09182414
46LIMK11.08629316
47SGK4941.08542370
48SGK2231.08542370
49SGK21.07287308
50PRPF4B1.06606317
51CDK51.05761007
52MAPK131.04547944
53CSNK1G11.03046665
54PRKD30.98613830
55MARK20.98197119
56FES0.95774979
57STK380.94246164
58MAPK150.94126499
59MAP3K40.92115982
60CAMK2G0.91736782
61ARAF0.90283708
62MAP2K70.89103431
63LATS20.87770538
64ICK0.87647165
65PRKCE0.85667881
66PRKCQ0.84823657
67DYRK20.82873326
68PHKG10.82052717
69PHKG20.82052717
70MAP3K90.79985057
71GRK50.78096511
72MYLK0.77760516
73EPHA30.77270062
74CDK140.76982584
75PAK30.75927307
76MAP3K130.75884318
77KSR10.75002126
78MAP4K20.74575772
79CAMK40.72577319
80CDK150.72049484
81IRAK20.71843447
82ADRBK20.71289109
83TYRO30.71026363
84GRK10.69837405
85CDK180.68903356
86MAP3K120.68399519
87ERBB30.67103071
88DYRK1A0.65029709
89CDK11A0.64936163
90BMPR20.63108931
91STK160.59899195
92CDK30.59188265
93PRKCZ0.59177869
94ADRBK10.58371153
95SGK30.58253073
96NME10.58097243
97MINK10.57628476
98MAPK120.57620661
99FYN0.56924123
100PLK20.55764530
101PRKG10.54678151
102STK110.51426602
103PTK2B0.50664141
104DDR20.49984860
105RPS6KA30.49978059
106RPS6KA50.49924903
107CAMK1G0.49694621
108DAPK10.49219329
109INSRR0.48272934
110EPHB20.47674127
111ROCK10.47658717
112PDPK10.47221104
113PRKD10.47137346
114PRKCG0.45409400
115RIPK40.45042290
116RIPK10.44756289
117CAMK10.43093011
118CCNB10.43031540
119CSNK1D0.42978783
120MKNK10.42593138
121BLK0.42026536
122MAP3K60.41863389
123WNK30.41700080
124CSNK1A10.40469767
125PRKACA0.40429625
126TLK10.40164969
127ERBB40.39908366
128PRKACB0.39725307
129TIE10.39341797
130PDGFRA0.38992352
131SGK10.38886831
132MAPK100.38256382
133TRIM280.37990590
134KSR20.37568854
135PIK3CA0.36431788
136YES10.30847807
137PRKCH0.30814785

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.18410172
2Fatty acid elongation_Homo sapiens_hsa000623.24149288
3Steroid biosynthesis_Homo sapiens_hsa001003.08155552
4Ether lipid metabolism_Homo sapiens_hsa005652.64131841
5Nicotine addiction_Homo sapiens_hsa050332.59219804
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.51561847
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49436252
8Oxidative phosphorylation_Homo sapiens_hsa001902.36089322
9GABAergic synapse_Homo sapiens_hsa047272.23699946
10Phototransduction_Homo sapiens_hsa047442.18092416
11Glutamatergic synapse_Homo sapiens_hsa047242.16292665
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15743901
13Serotonergic synapse_Homo sapiens_hsa047261.99608249
14Morphine addiction_Homo sapiens_hsa050321.97983620
15Axon guidance_Homo sapiens_hsa043601.70854820
16Circadian entrainment_Homo sapiens_hsa047131.68171222
17Alzheimers disease_Homo sapiens_hsa050101.67758752
18Sphingolipid metabolism_Homo sapiens_hsa006001.67418442
19Parkinsons disease_Homo sapiens_hsa050121.65525021
20Protein export_Homo sapiens_hsa030601.59921081
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55801749
22Collecting duct acid secretion_Homo sapiens_hsa049661.55663014
23Synaptic vesicle cycle_Homo sapiens_hsa047211.54971599
24Long-term depression_Homo sapiens_hsa047301.54274752
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.43575544
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41619307
27Salivary secretion_Homo sapiens_hsa049701.41205596
28Dopaminergic synapse_Homo sapiens_hsa047281.35304884
29Taste transduction_Homo sapiens_hsa047421.34720618
30Cocaine addiction_Homo sapiens_hsa050301.33427575
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29475242
32Amphetamine addiction_Homo sapiens_hsa050311.28023310
33Cholinergic synapse_Homo sapiens_hsa047251.27727477
34Cardiac muscle contraction_Homo sapiens_hsa042601.26928618
35Linoleic acid metabolism_Homo sapiens_hsa005911.26862292
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12871587
37Vibrio cholerae infection_Homo sapiens_hsa051101.10711823
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10505884
39Gastric acid secretion_Homo sapiens_hsa049711.09463817
40Olfactory transduction_Homo sapiens_hsa047401.07779079
41Sulfur metabolism_Homo sapiens_hsa009201.07768131
42Long-term potentiation_Homo sapiens_hsa047201.07014435
43Renin secretion_Homo sapiens_hsa049241.03340155
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98627870
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98067976
46Huntingtons disease_Homo sapiens_hsa050160.95986887
47Type II diabetes mellitus_Homo sapiens_hsa049300.94439659
48Insulin secretion_Homo sapiens_hsa049110.93146870
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92135883
50Calcium signaling pathway_Homo sapiens_hsa040200.92033642
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.90572471
52Circadian rhythm_Homo sapiens_hsa047100.89935712
53Histidine metabolism_Homo sapiens_hsa003400.89410410
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87386554
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.87183578
56Vitamin B6 metabolism_Homo sapiens_hsa007500.84723856
57Rheumatoid arthritis_Homo sapiens_hsa053230.82689418
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81039140
59Renal cell carcinoma_Homo sapiens_hsa052110.80551116
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79480613
61Ras signaling pathway_Homo sapiens_hsa040140.79265413
62Oxytocin signaling pathway_Homo sapiens_hsa049210.78611407
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78029898
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77206184
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77135456
66Butanoate metabolism_Homo sapiens_hsa006500.77009843
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76879481
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75768429
69Pancreatic secretion_Homo sapiens_hsa049720.75696014
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74958440
71cAMP signaling pathway_Homo sapiens_hsa040240.73979896
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.73835344
73Autoimmune thyroid disease_Homo sapiens_hsa053200.67418412
74Glioma_Homo sapiens_hsa052140.67166186
75ErbB signaling pathway_Homo sapiens_hsa040120.65766829
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.65658584
77Dorso-ventral axis formation_Homo sapiens_hsa043200.64641182
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63920600
79Ovarian steroidogenesis_Homo sapiens_hsa049130.61790295
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61247373
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61176763
82Arachidonic acid metabolism_Homo sapiens_hsa005900.60586239
83Gap junction_Homo sapiens_hsa045400.60444143
84Choline metabolism in cancer_Homo sapiens_hsa052310.57813402
85Bile secretion_Homo sapiens_hsa049760.57714227
86Mineral absorption_Homo sapiens_hsa049780.57676210
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57555937
88Melanogenesis_Homo sapiens_hsa049160.56595719
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54906410
90Tight junction_Homo sapiens_hsa045300.54019501
91GnRH signaling pathway_Homo sapiens_hsa049120.53596990
92Alcoholism_Homo sapiens_hsa050340.53078743
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52589627
94Endocytosis_Homo sapiens_hsa041440.48898172
95Hippo signaling pathway_Homo sapiens_hsa043900.48469481
96Oocyte meiosis_Homo sapiens_hsa041140.47783777
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46274434
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45068305
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.44727833
100MAPK signaling pathway_Homo sapiens_hsa040100.44708299
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44357640
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43794494
103ABC transporters_Homo sapiens_hsa020100.43147350
104Arginine and proline metabolism_Homo sapiens_hsa003300.42776960
105Melanoma_Homo sapiens_hsa052180.41893476
106Fatty acid biosynthesis_Homo sapiens_hsa000610.40039246
107Protein digestion and absorption_Homo sapiens_hsa049740.39800077
108ECM-receptor interaction_Homo sapiens_hsa045120.38026439
109Phagosome_Homo sapiens_hsa041450.34007737
110Hedgehog signaling pathway_Homo sapiens_hsa043400.33871475
111Focal adhesion_Homo sapiens_hsa045100.32836427
112Regulation of autophagy_Homo sapiens_hsa041400.30717985
113Dilated cardiomyopathy_Homo sapiens_hsa054140.30458344
114Glucagon signaling pathway_Homo sapiens_hsa049220.30151024
115Inositol phosphate metabolism_Homo sapiens_hsa005620.29394292
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28857371
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27769687
118Estrogen signaling pathway_Homo sapiens_hsa049150.26994942
119Wnt signaling pathway_Homo sapiens_hsa043100.26943402
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26735769
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26658260
122Thyroid hormone synthesis_Homo sapiens_hsa049180.25961420
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24804539
124Rap1 signaling pathway_Homo sapiens_hsa040150.24308311

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