SFXN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)4.76747000
2vocalization behavior (GO:0071625)4.60694859
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.59509486
4protein localization to synapse (GO:0035418)4.50125796
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.47685561
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.45119611
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.38759694
8synaptic vesicle maturation (GO:0016188)4.36364536
9barbed-end actin filament capping (GO:0051016)4.24170634
10locomotory exploration behavior (GO:0035641)4.18796549
11regulation of synaptic vesicle exocytosis (GO:2000300)4.09385455
12regulation of glutamate receptor signaling pathway (GO:1900449)4.03503152
13glutamate secretion (GO:0014047)3.98902804
14regulation of synapse structural plasticity (GO:0051823)3.82055998
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.79738553
16protein localization to endosome (GO:0036010)3.73923936
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69005048
18neuron cell-cell adhesion (GO:0007158)3.67963532
19postsynaptic membrane organization (GO:0001941)3.60122864
20exploration behavior (GO:0035640)3.56893457
21regulation of synaptic vesicle transport (GO:1902803)3.55565442
22neurotransmitter-gated ion channel clustering (GO:0072578)3.54281921
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.47334477
24positive regulation of synapse maturation (GO:0090129)3.37330484
25synaptic vesicle endocytosis (GO:0048488)3.30887604
26Golgi transport vesicle coating (GO:0048200)3.29105746
27COPI coating of Golgi vesicle (GO:0048205)3.29105746
28actin filament depolymerization (GO:0030042)3.26157812
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.23586780
30neurotransmitter secretion (GO:0007269)3.22465626
31glutamate receptor signaling pathway (GO:0007215)3.22065449
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21090895
33long-term synaptic potentiation (GO:0060291)3.19669521
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.19366050
35synaptic transmission, glutamatergic (GO:0035249)3.19313344
36neuron-neuron synaptic transmission (GO:0007270)3.15150319
37layer formation in cerebral cortex (GO:0021819)3.14886261
38adhesion of symbiont to host cell (GO:0044650)3.12467099
39virion attachment to host cell (GO:0019062)3.12467099
40regulation of neuronal synaptic plasticity (GO:0048168)3.11365340
41positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07951944
42neuronal action potential propagation (GO:0019227)3.04318821
43mannose metabolic process (GO:0006013)3.03291774
44regulation of synaptic transmission, glutamatergic (GO:0051966)3.02978974
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.02422537
46long-term memory (GO:0007616)3.00110088
47positive regulation of membrane potential (GO:0045838)2.96646712
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95985376
49cellular potassium ion homeostasis (GO:0030007)2.95963585
50positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95702111
51glycosphingolipid catabolic process (GO:0046479)2.94650364
52adhesion of symbiont to host (GO:0044406)2.94431851
53positive regulation of neurotransmitter secretion (GO:0001956)2.94304564
54skin morphogenesis (GO:0043589)2.92583740
55regulation of neurotransmitter secretion (GO:0046928)2.92053259
56apoptotic cell clearance (GO:0043277)2.91603498
57positive regulation of neurotransmitter transport (GO:0051590)2.89020374
58stress fiber assembly (GO:0043149)2.87710612
59response to auditory stimulus (GO:0010996)2.87689071
60cell adhesion mediated by integrin (GO:0033627)2.87026418
61fibril organization (GO:0097435)2.86223811
62proline transport (GO:0015824)2.85712288
63regulation of postsynaptic membrane potential (GO:0060078)2.85092540
64regulation of synaptic plasticity (GO:0048167)2.83135752
65response to pheromone (GO:0019236)2.82838062
66extracellular fibril organization (GO:0043206)2.80251843
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.80112261
68regulation of vesicle fusion (GO:0031338)2.79913171
69angiotensin maturation (GO:0002003)2.77517606
70regulation of synapse maturation (GO:0090128)2.76179929
71activation of protein kinase A activity (GO:0034199)2.75594426
72regulation of extracellular matrix disassembly (GO:0010715)2.72774038
73regulation of neurotransmitter transport (GO:0051588)2.71035488
74positive regulation of synaptic transmission (GO:0050806)2.70216170
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69631993
76cytoskeletal anchoring at plasma membrane (GO:0007016)2.69610520
77positive regulation of receptor recycling (GO:0001921)2.69527553
78auditory behavior (GO:0031223)2.68539206
79glycolipid catabolic process (GO:0019377)2.67623175
80protein retention in ER lumen (GO:0006621)2.64741717
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.62869644
82presynaptic membrane assembly (GO:0097105)2.62587730
83regulation of voltage-gated calcium channel activity (GO:1901385)2.62367511
84neuron recognition (GO:0008038)2.61474529
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.61443561
86response to histamine (GO:0034776)2.60935103
87peptide catabolic process (GO:0043171)2.60843504
88G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.60714780
89hypotonic response (GO:0006971)2.60058162
90cerebellar Purkinje cell differentiation (GO:0021702)2.58465061
91positive regulation of extracellular matrix organization (GO:1903055)2.58157669
92learning (GO:0007612)2.57629081
93pinocytosis (GO:0006907)2.56224740
94neurotransmitter transport (GO:0006836)2.55708635
95membrane depolarization (GO:0051899)2.55131262
96positive regulation of fibroblast migration (GO:0010763)2.53433803
97sodium ion export (GO:0071436)2.52128489
98regulation of synaptic transmission, GABAergic (GO:0032228)2.51010246
99regulation of dendritic spine morphogenesis (GO:0061001)2.50123483
100positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49935589
101synapse assembly (GO:0007416)2.48782809
102negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47684166
103synaptic vesicle transport (GO:0048489)2.47610883
104establishment of synaptic vesicle localization (GO:0097480)2.47610883
105maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.47420780
106retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.46434843
107negative regulation of erythrocyte differentiation (GO:0045647)2.45766975
108dendrite morphogenesis (GO:0048813)2.45534433
109regulation of synaptic transmission (GO:0050804)2.44316091
110dopamine receptor signaling pathway (GO:0007212)2.43312145
111membrane depolarization during action potential (GO:0086010)2.42974917
112substrate-dependent cell migration (GO:0006929)2.42910585
113prepulse inhibition (GO:0060134)2.42692864
114behavioral defense response (GO:0002209)2.40818949
115behavioral fear response (GO:0001662)2.40818949
116membrane hyperpolarization (GO:0060081)2.40500633
117gamma-aminobutyric acid transport (GO:0015812)2.39672302
118cortical actin cytoskeleton organization (GO:0030866)2.39367811
119positive regulation of vesicle fusion (GO:0031340)2.38385974
120clathrin coat assembly (GO:0048268)2.37854617
121synaptic transmission (GO:0007268)2.37770718
122dendritic spine morphogenesis (GO:0060997)2.36656018
123presynaptic membrane organization (GO:0097090)2.36248955
124transmission of nerve impulse (GO:0019226)2.36102917
125transferrin transport (GO:0033572)2.36100361
126hemidesmosome assembly (GO:0031581)2.34833860
127semaphorin-plexin signaling pathway (GO:0071526)2.34790834
128synaptic transmission, dopaminergic (GO:0001963)2.34589081
129regulation of T-helper 2 cell differentiation (GO:0045628)2.34306953
130neuromuscular process controlling balance (GO:0050885)2.34013513
131endothelial cell chemotaxis (GO:0035767)2.33840737
132regulation of dendritic spine development (GO:0060998)2.32013111
133axonal fasciculation (GO:0007413)2.32009658
134regulation of early endosome to late endosome transport (GO:2000641)2.31412062
135cerebellar granule cell differentiation (GO:0021707)2.31075406
136negative regulation of smooth muscle cell migration (GO:0014912)2.30701102
137membrane raft organization (GO:0031579)2.30599490
138cell migration in hindbrain (GO:0021535)2.29787280
139innervation (GO:0060384)2.29738488
140type B pancreatic cell proliferation (GO:0044342)2.27810856
141regulation of glutamate secretion (GO:0014048)2.27376970
142response to laminar fluid shear stress (GO:0034616)2.26241784
143cortical cytoskeleton organization (GO:0030865)2.25756030
144endocytic recycling (GO:0032456)2.25630017
145negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.21934408
146ceramide catabolic process (GO:0046514)2.21766733
147endodermal cell differentiation (GO:0035987)2.20975744
148regulation of metalloenzyme activity (GO:0048552)2.16617016
149regulation of ARF protein signal transduction (GO:0032012)2.16613185
150positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.15535276
151positive regulation of axon extension (GO:0045773)2.14964934
152cell-substrate junction assembly (GO:0007044)2.13386170
153cellular copper ion homeostasis (GO:0006878)2.13335685
154regulation of integrin-mediated signaling pathway (GO:2001044)2.09182420
155basement membrane organization (GO:0071711)2.08267177
156negative regulation of fatty acid transport (GO:2000192)2.07928720
157keratan sulfate catabolic process (GO:0042340)2.07725646
158dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.06357189
159actin filament capping (GO:0051693)2.05614360
160actin filament bundle assembly (GO:0051017)2.04709885
161actin filament bundle organization (GO:0061572)2.04709885
162cell-cell junction maintenance (GO:0045217)2.04371719
163protein targeting to plasma membrane (GO:0072661)2.03728647
164cellular response to thyroid hormone stimulus (GO:0097067)2.03664358
165vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.03467706
166regulation of leukocyte degranulation (GO:0043300)2.02840292
167regulation of collagen metabolic process (GO:0010712)2.02314765
168response to magnesium ion (GO:0032026)2.02215100
169positive regulation of blood vessel endothelial cell migration (GO:0043536)2.01563021
170negative regulation of protein localization to plasma membrane (GO:1903077)2.01161299
171regulation of extracellular matrix organization (GO:1903053)2.01131322
172hyaluronan catabolic process (GO:0030214)2.00527334
173endoplasmic reticulum calcium ion homeostasis (GO:0032469)1.98903157
174positive regulation of protein dephosphorylation (GO:0035307)1.98001519
175platelet degranulation (GO:0002576)1.97583482
176chondroitin sulfate catabolic process (GO:0030207)1.96256062
177cellular response to prostaglandin stimulus (GO:0071379)1.93944000
178regulation of monocyte chemotaxis (GO:0090025)1.93763991
179positive regulation of pseudopodium assembly (GO:0031274)1.93426491
180epithelial cell-cell adhesion (GO:0090136)1.92726611
181negative regulation of nitric oxide biosynthetic process (GO:0045019)1.92577830
182cell volume homeostasis (GO:0006884)1.91737907
183oligosaccharide catabolic process (GO:0009313)1.91300700
184regulation of ARF GTPase activity (GO:0032312)1.90623415
185positive regulation of endothelial cell apoptotic process (GO:2000353)1.88920575
186regulation of cholesterol homeostasis (GO:2000188)1.88042068
187regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.86963169
188positive regulation of Cdc42 GTPase activity (GO:0043089)1.86889168
189membrane protein ectodomain proteolysis (GO:0006509)1.86402234
190regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)1.86058419
191cellular response to nutrient (GO:0031670)1.85715629
192positive regulation of leukocyte degranulation (GO:0043302)1.85488979
193macroautophagy (GO:0016236)1.84897515
194vascular endothelial growth factor signaling pathway (GO:0038084)1.84200337
195response to progesterone (GO:0032570)1.83019834
196regulation of regulated secretory pathway (GO:1903305)1.82647185

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.41838870
2GBX2_23144817_ChIP-Seq_PC3_Human3.41315887
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.33264550
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.22651319
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05821379
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96795147
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89449054
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69341837
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69341837
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67334943
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64061016
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63895289
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.60570741
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54198398
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.40087330
16LXR_22292898_ChIP-Seq_THP-1_Human2.38583411
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37624815
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37526121
19* ELK3_25401928_ChIP-Seq_HUVEC_Human2.36754167
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.35756188
21DROSHA_22980978_ChIP-Seq_HELA_Human2.33666108
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27714946
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27014192
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.24507900
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17089721
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.15257338
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.13600324
28* RNF2_27304074_Chip-Seq_ESCs_Mouse2.07131237
29* REST_21632747_ChIP-Seq_MESCs_Mouse2.03716812
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.99160353
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96649556
32AR_21572438_ChIP-Seq_LNCaP_Human1.94548809
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.91979546
34CLOCK_20551151_ChIP-Seq_293T_Human1.84959101
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80688774
36* GATA2_21666600_ChIP-Seq_HMVEC_Human1.76785746
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75353761
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72261514
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71029360
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67216367
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.64052569
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.63450570
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60664183
44* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57979647
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57910102
46* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56042984
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54519213
48* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52794463
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52096745
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.51245273
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50129548
52VDR_21846776_ChIP-Seq_THP-1_Human1.49026892
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47410548
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.43289521
55SMAD4_21799915_ChIP-Seq_A2780_Human1.42914949
56* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42647686
57KDM2B_26808549_Chip-Seq_DND41_Human1.42236299
58VDR_24763502_ChIP-Seq_THP-1_Human1.40591770
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40444263
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39536146
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35243520
62* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35099688
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33651490
64* TCF7_22412390_ChIP-Seq_EML_Mouse1.33060979
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32938780
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31921390
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30773445
68TAF15_26573619_Chip-Seq_HEK293_Human1.30685601
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29751380
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29402133
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28796699
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28321691
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27767545
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27749776
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27655676
76TP53_22127205_ChIP-Seq_IMR90_Human1.26886164
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.25894723
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24832235
79* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24212147
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23760123
81* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23594316
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22718859
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22111169
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.21869584
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.21839403
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21365954
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20755710
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20517302
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20149840
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.19719649
91P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19695909
92SPI1_23127762_ChIP-Seq_K562_Human1.19087132
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19061352
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18225239
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18015955
96MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17107425
97TP53_18474530_ChIP-ChIP_U2OS_Human1.16335990
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15941552
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.15294920
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15201166
101SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15138067
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14832047
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13085706
104P300_19829295_ChIP-Seq_ESCs_Human1.12839948
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.12597905
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.12584731
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12429669
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.12291636
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11436725
110AHR_22903824_ChIP-Seq_MCF-7_Human1.11310809
111AR_25329375_ChIP-Seq_VCAP_Human1.11310117
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11225402
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11225402
114CBX2_27304074_Chip-Seq_ESCs_Mouse1.11063646
115SMC4_20622854_ChIP-Seq_HELA_Human1.09175983
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09166195
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08513291
118TET1_21490601_ChIP-Seq_MESCs_Mouse1.08188542
119BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07726329
120KDM2B_26808549_Chip-Seq_JURKAT_Human1.07723576
121NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07341254
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07269658
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06727487
124SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06497400
125ZNF263_19887448_ChIP-Seq_K562_Human1.06479131
126TET1_21451524_ChIP-Seq_MESCs_Mouse1.06100321
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05452307
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04638961
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04480986
130ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04026072
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03891168
132* SA1_27219007_Chip-Seq_ERYTHROID_Human1.03873514
133RXR_22158963_ChIP-Seq_LIVER_Mouse1.03358611
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02965516
135FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02573935
136PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02446456
137SOX2_21211035_ChIP-Seq_LN229_Gbm1.02229172
138KDM2B_26808549_Chip-Seq_K562_Human1.02185421
139RNF2_27304074_Chip-Seq_NSC_Mouse1.02051898
140RING1B_27294783_Chip-Seq_NPCs_Mouse1.02042910
141TP53_23651856_ChIP-Seq_MEFs_Mouse1.01939146
142P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01758460
143* P68_20966046_ChIP-Seq_HELA_Human1.01554412
144PRDM14_20953172_ChIP-Seq_ESCs_Human1.00494232
145ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99973340
146TP63_22573176_ChIP-Seq_HFKS_Human0.99804924
147GATA1_19941826_ChIP-Seq_K562_Human0.99631750
148TP53_16413492_ChIP-PET_HCT116_Human0.99002396
149* SOX2_20726797_ChIP-Seq_SW620_Human0.98829629
150TBX20_22080862_ChIP-Seq_HEART_Mouse0.98798675
151TBX20_22328084_ChIP-Seq_HEART_Mouse0.98798675
152CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98705563
153TP53_20018659_ChIP-ChIP_R1E_Mouse0.98345235
154AR_19668381_ChIP-Seq_PC3_Human0.98074322
155UBF1/2_26484160_Chip-Seq_HMECs_Human0.98043087
156CDX2_20551321_ChIP-Seq_CACO-2_Human0.97622966
157* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97151438
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.97080468
159EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96873973
160SMAD3_21741376_ChIP-Seq_EPCs_Human0.96457361
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96115644
162IGF1R_20145208_ChIP-Seq_DFB_Human0.95428768
163OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95316574
164* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93302844
165ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93155602
166YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92182718
167KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91342398
168SMAD3_21741376_ChIP-Seq_HESCs_Human0.89344366
169* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87140991
170STAT3_23295773_ChIP-Seq_U87_Human0.86835816
171RXR_22108803_ChIP-Seq_LS180_Human0.85906300
172SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85274967
173CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83002576
174SMAD3_21741376_ChIP-Seq_ESCs_Human0.82942376
175TCF4_23295773_ChIP-Seq_U87_Human0.80777324
176CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80738133
177MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80143942
178SMAD4_21741376_ChIP-Seq_HESCs_Human0.79534396
179ER_23166858_ChIP-Seq_MCF-7_Human0.79024720
180RUNX2_22187159_ChIP-Seq_PCA_Human0.78917354
181GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77636841
182RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.77558140
183NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76502041

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.60023452
2MP0003880_abnormal_central_pattern3.72423284
3MP0005058_abnormal_lysosome_morphology3.59787754
4MP0003635_abnormal_synaptic_transmissio3.54958920
5MP0009840_abnormal_foam_cell2.99785329
6MP0001968_abnormal_touch/_nociception2.91388600
7MP0009745_abnormal_behavioral_response2.90832382
8MP0003705_abnormal_hypodermis_morpholog2.81905192
9MP0002063_abnormal_learning/memory/cond2.80979549
10MP0003191_abnormal_cellular_cholesterol2.80033136
11MP0002064_seizures2.67753374
12MP0009046_muscle_twitch2.64608120
13MP0004270_analgesia2.59701956
14MP0002572_abnormal_emotion/affect_behav2.41402509
15MP0002736_abnormal_nociception_after2.38802876
16MP0003566_abnormal_cell_adhesion2.35269486
17MP0002822_catalepsy2.31997248
18MP0005360_urolithiasis2.27088066
19MP0005257_abnormal_intraocular_pressure2.24345567
20MP0002735_abnormal_chemical_nociception2.22444618
21MP0003436_decreased_susceptibility_to2.18106119
22MP0002734_abnormal_mechanical_nocicepti2.11794496
23MP0001486_abnormal_startle_reflex2.08760507
24MP0002877_abnormal_melanocyte_morpholog2.05275639
25MP0002272_abnormal_nervous_system2.02875417
26MP0001188_hyperpigmentation2.02867435
27MP0000604_amyloidosis2.01505993
28MP0004858_abnormal_nervous_system1.99117919
29MP0005423_abnormal_somatic_nervous1.92422948
30MP0008260_abnormal_autophagy1.86386305
31MP0001970_abnormal_pain_threshold1.82967968
32MP0002733_abnormal_thermal_nociception1.77469098
33MP0008569_lethality_at_weaning1.77089007
34MP0001501_abnormal_sleep_pattern1.76963836
35MP0004272_abnormal_basement_membrane1.73723333
36MP0003300_gastrointestinal_ulcer1.72377558
37MP0001984_abnormal_olfaction1.72223991
38MP0009780_abnormal_chondrocyte_physiolo1.71342005
39MP0006082_CNS_inflammation1.68867575
40MP0005023_abnormal_wound_healing1.66863773
41MP0002067_abnormal_sensory_capabilities1.64279779
42MP0001849_ear_inflammation1.63388545
43MP0004811_abnormal_neuron_physiology1.62176965
44MP0005623_abnormal_meninges_morphology1.60162352
45MP0005646_abnormal_pituitary_gland1.59934466
46MP0003879_abnormal_hair_cell1.59195734
47MP0000569_abnormal_digit_pigmentation1.57227473
48MP0002184_abnormal_innervation1.56607219
49MP0005464_abnormal_platelet_physiology1.56594725
50MP0002557_abnormal_social/conspecific_i1.55821534
51MP0000858_altered_metastatic_potential1.49674699
52MP0001542_abnormal_bone_strength1.49300403
53MP0001440_abnormal_grooming_behavior1.49254584
54MP0000343_altered_response_to1.48875166
55MP0010368_abnormal_lymphatic_system1.47336958
56MP0003828_pulmonary_edema1.42794256
57MP0006054_spinal_hemorrhage1.41864182
58MP0010386_abnormal_urinary_bladder1.41637227
59MP0006276_abnormal_autonomic_nervous1.36062349
60MP0003724_increased_susceptibility_to1.35247499
61MP0004947_skin_inflammation1.34557307
62MP0000778_abnormal_nervous_system1.32325488
63MP0005165_increased_susceptibility_to1.32017144
64MP0000920_abnormal_myelination1.30914827
65MP0002909_abnormal_adrenal_gland1.30805663
66MP0002896_abnormal_bone_mineralization1.29653252
67MP0001958_emphysema1.27906191
68MP0002090_abnormal_vision1.27555359
69MP0003950_abnormal_plasma_membrane1.27303052
70MP0003279_aneurysm1.25312433
71MP0000767_abnormal_smooth_muscle1.24832701
72MP0001502_abnormal_circadian_rhythm1.24703400
73MP0004510_myositis1.24603882
74MP0002419_abnormal_innate_immunity1.24074901
75MP0008438_abnormal_cutaneous_collagen1.22032455
76MP0005164_abnormal_response_to1.21581951
77MP0005503_abnormal_tendon_morphology1.20035937
78MP0000955_abnormal_spinal_cord1.17881609
79MP0002882_abnormal_neuron_morphology1.17782738
80MP0003690_abnormal_glial_cell1.14455568
81MP0004924_abnormal_behavior1.10450692
82MP0005386_behavior/neurological_phenoty1.10450692
83MP0000751_myopathy1.09940568
84MP0003453_abnormal_keratinocyte_physiol1.09884313
85MP0005645_abnormal_hypothalamus_physiol1.09713451
86MP0003633_abnormal_nervous_system1.09668599
87MP0010234_abnormal_vibrissa_follicle1.07569448
88MP0005390_skeleton_phenotype1.07527360
89MP0003172_abnormal_lysosome_physiology1.06194626
90MP0002066_abnormal_motor_capabilities/c1.04639536
91MP0000249_abnormal_blood_vessel1.04527875
92MP0002933_joint_inflammation1.04310823
93MP0001905_abnormal_dopamine_level1.03717982
94MP0003448_altered_tumor_morphology1.01988433
95MP0005409_darkened_coat_color1.01901332
96MP0003183_abnormal_peptide_metabolism1.01480589
97MP0010155_abnormal_intestine_physiology1.01082778
98MP0001853_heart_inflammation0.97270966
99MP0002060_abnormal_skin_morphology0.96730605
100MP0008961_abnormal_basal_metabolism0.96476296
101MP0009384_cardiac_valve_regurgitation0.96377338
102MP0005365_abnormal_bile_salt0.95722444
103MP0005451_abnormal_body_composition0.94466230
104MP0003787_abnormal_imprinting0.93898192
105MP0003045_fibrosis0.92375498
106MP0005025_abnormal_response_to0.92086901
107MP0003075_altered_response_to0.91101222
108MP0005551_abnormal_eye_electrophysiolog0.90674745
109MP0009278_abnormal_bone_marrow0.89343251
110MP0003329_amyloid_beta_deposits0.88993307
111MP0004883_abnormal_blood_vessel0.88441075
112MP0008004_abnormal_stomach_pH0.87757971
113MP0000003_abnormal_adipose_tissue0.87008094
114MP0003122_maternal_imprinting0.86210028
115MP0002089_abnormal_postnatal_growth/wei0.84326715
116MP0000013_abnormal_adipose_tissue0.84127747
117MP0008874_decreased_physiological_sensi0.83396805
118MP0005508_abnormal_skeleton_morphology0.82632979
119MP0004742_abnormal_vestibular_system0.82213378
120MP0002295_abnormal_pulmonary_circulatio0.81384515
121MP0001348_abnormal_lacrimal_gland0.79298907
122MP0000015_abnormal_ear_pigmentation0.79076559
123MP0003631_nervous_system_phenotype0.78778480
124MP0005275_abnormal_skin_tensile0.78370516
125MP0003795_abnormal_bone_structure0.78354540
126MP0000465_gastrointestinal_hemorrhage0.78077345
127MP0005167_abnormal_blood-brain_barrier0.77759487
128MP0003303_peritoneal_inflammation0.77595570
129MP0005388_respiratory_system_phenotype0.76556437
130MP0002133_abnormal_respiratory_system0.76556437
131MP0002069_abnormal_eating/drinking_beha0.74785859
132MP0001835_abnormal_antigen_presentation0.74323425
133MP0005000_abnormal_immune_tolerance0.74143515
134MP0003634_abnormal_glial_cell0.73990201
135MP0001664_abnormal_digestion0.73615658
136MP0009764_decreased_sensitivity_to0.73521853
137MP0002152_abnormal_brain_morphology0.72751301
138MP0005394_taste/olfaction_phenotype0.72189019
139MP0005499_abnormal_olfactory_system0.72189019
140MP0001243_abnormal_dermal_layer0.72075365
141MP0000534_abnormal_ureter_morphology0.71114920
142MP0002332_abnormal_exercise_endurance0.70971676
143MP0001299_abnormal_eye_distance/0.70437260
144MP0009785_altered_susceptibility_to0.69056690
145MP0002998_abnormal_bone_remodeling0.68895714
146MP0004142_abnormal_muscle_tone0.67603503
147MP0005375_adipose_tissue_phenotype0.66919119
148MP0000733_abnormal_muscle_development0.66344698
149MP0001845_abnormal_inflammatory_respons0.65579566
150MP0008875_abnormal_xenobiotic_pharmacok0.64584281
151MP0001851_eye_inflammation0.64406903
152MP0003091_abnormal_cell_migration0.63802711
153MP0000681_abnormal_thyroid_gland0.63775508
154MP0004484_altered_response_of0.63120874
155MP0001529_abnormal_vocalization0.62091057
156MP0002148_abnormal_hypersensitivity_rea0.61986699
157MP0008469_abnormal_protein_level0.61149307
158MP0001177_atelectasis0.61063386
159MP0000747_muscle_weakness0.60245138
160MP0005166_decreased_susceptibility_to0.59996969
161MP0002752_abnormal_somatic_nervous0.59932377
162MP0001533_abnormal_skeleton_physiology0.59518313
163MP0000631_abnormal_neuroendocrine_gland0.58691971
164MP0004145_abnormal_muscle_electrophysio0.57333888
165MP0004885_abnormal_endolymph0.56327219
166MP0002229_neurodegeneration0.55566430
167MP0001963_abnormal_hearing_physiology0.55143213
168MP0005174_abnormal_tail_pigmentation0.52358126
169MP0005595_abnormal_vascular_smooth0.51542373
170MP0001943_abnormal_respiration0.51192634

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.99049944
2Myokymia (HP:0002411)4.89571126
3Focal seizures (HP:0007359)4.56576832
4Epileptic encephalopathy (HP:0200134)4.36908173
5Febrile seizures (HP:0002373)4.25416944
6Atonic seizures (HP:0010819)3.83677349
7Abnormality of glycolipid metabolism (HP:0010969)3.75599582
8Abnormality of liposaccharide metabolism (HP:0010968)3.75599582
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.75599582
10Dysostosis multiplex (HP:0000943)3.75324690
11Visual hallucinations (HP:0002367)3.69363796
12Progressive cerebellar ataxia (HP:0002073)3.64256950
13Neurofibrillary tangles (HP:0002185)3.42510705
14Cervical subluxation (HP:0003308)3.40812506
15Urinary glycosaminoglycan excretion (HP:0003541)3.28024904
16Mucopolysacchariduria (HP:0008155)3.28024904
17Abnormality of mucopolysaccharide metabolism (HP:0011020)3.22776006
18Abnormality of polysaccharide metabolism (HP:0011012)3.22776006
19Abnormality of glycosaminoglycan metabolism (HP:0004371)3.22776006
20Absence seizures (HP:0002121)3.04992704
21Spinal canal stenosis (HP:0003416)3.03075627
22Ankle clonus (HP:0011448)2.95107192
23Action tremor (HP:0002345)2.91536755
24Distal upper limb amyotrophy (HP:0007149)2.91073089
25Upper limb amyotrophy (HP:0009129)2.91073089
26Supranuclear gaze palsy (HP:0000605)2.87885337
27Amyloidosis (HP:0011034)2.82955381
28Abnormality of binocular vision (HP:0011514)2.81096253
29Diplopia (HP:0000651)2.81096253
30Generalized tonic-clonic seizures (HP:0002069)2.77381203
31Interstitial pulmonary disease (HP:0006530)2.74365160
32Dialeptic seizures (HP:0011146)2.70686792
33Cerebral inclusion bodies (HP:0100314)2.68500534
34Axonal loss (HP:0003447)2.63223988
35Mutism (HP:0002300)2.62281790
36Systemic lupus erythematosus (HP:0002725)2.60344812
37Hand muscle atrophy (HP:0009130)2.60129427
38Broad-based gait (HP:0002136)2.58553859
39Abnormal eating behavior (HP:0100738)2.58087730
40Thin bony cortex (HP:0002753)2.56939035
41Depression (HP:0000716)2.55688552
42Truncal ataxia (HP:0002078)2.55386132
43Hypoventilation (HP:0002791)2.53814882
44Protrusio acetabuli (HP:0003179)2.50352341
45Joint stiffness (HP:0001387)2.48230652
46Abnormal hair whorl (HP:0010721)2.47800804
47Loss of speech (HP:0002371)2.47774891
48Nuclear cataract (HP:0100018)2.45761459
49Wormian bones (HP:0002645)2.45619072
50Distal lower limb muscle weakness (HP:0009053)2.44865258
51Short nail (HP:0001799)2.38739108
52Gaze-evoked nystagmus (HP:0000640)2.38734316
53Polyphagia (HP:0002591)2.37540824
54Vacuolated lymphocytes (HP:0001922)2.36256427
55Hyperventilation (HP:0002883)2.35098677
56Abnormality of the nasal mucosa (HP:0000433)2.32714595
57Genetic anticipation (HP:0003743)2.32299070
58Stereotypic behavior (HP:0000733)2.31690674
59Spondylolisthesis (HP:0003302)2.29631147
60Lower limb amyotrophy (HP:0007210)2.28143962
61Broad face (HP:0000283)2.25352894
62Papilledema (HP:0001085)2.25298951
63Narrow nasal bridge (HP:0000446)2.24385149
64Absent speech (HP:0001344)2.19134077
65Arterial tortuosity (HP:0005116)2.19098051
66Vascular tortuosity (HP:0004948)2.18966398
67Torticollis (HP:0000473)2.18202944
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.18126857
69Osteolytic defects of the hand bones (HP:0009699)2.18126857
70Abnormality of macrophages (HP:0004311)2.15370871
71Hemiplegia (HP:0002301)2.15055169
72Poor eye contact (HP:0000817)2.14721572
73Dilatation of the ascending aorta (HP:0005111)2.13613741
74Aortic dissection (HP:0002647)2.11860444
75Spinal rigidity (HP:0003306)2.10325634
76Dysdiadochokinesis (HP:0002075)2.07938547
77Amblyopia (HP:0000646)2.07408268
78Peritonitis (HP:0002586)2.07297140
79Achilles tendon contracture (HP:0001771)2.06983793
80Anxiety (HP:0000739)2.06301206
81Myocardial infarction (HP:0001658)2.05647195
82Failure to thrive in infancy (HP:0001531)2.04839121
83Asymmetric septal hypertrophy (HP:0001670)2.04601203
84Impaired smooth pursuit (HP:0007772)2.01082200
85Atrophic scars (HP:0001075)2.00477878
86Purpura (HP:0000979)1.99729778
87Increased connective tissue (HP:0009025)1.99692110
88Apathy (HP:0000741)1.99658471
89Mitral regurgitation (HP:0001653)1.98282247
90Aneurysm (HP:0002617)1.98026607
91Limb dystonia (HP:0002451)1.97629768
92Progressive inability to walk (HP:0002505)1.96152515
93Malnutrition (HP:0004395)1.95515718
94Urinary bladder sphincter dysfunction (HP:0002839)1.95047442
95Abnormality of the Achilles tendon (HP:0005109)1.94806489
96Nasal polyposis (HP:0100582)1.93971017
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93361332
98Diminished motivation (HP:0000745)1.92013261
99Impaired social interactions (HP:0000735)1.91609158
100Abnormal social behavior (HP:0012433)1.91609158
101Mildly elevated creatine phosphokinase (HP:0008180)1.89853474
102Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89271977
103Mitral stenosis (HP:0001718)1.89158437
104J-shaped sella turcica (HP:0002680)1.89110305
105Palpebral edema (HP:0100540)1.89056917
106Obstructive sleep apnea (HP:0002870)1.88259439
107Bladder diverticulum (HP:0000015)1.87385114
108Hemiparesis (HP:0001269)1.87137745
109Focal dystonia (HP:0004373)1.86952829
110Agitation (HP:0000713)1.85958135
111Dysmetric saccades (HP:0000641)1.85930306
112Blue sclerae (HP:0000592)1.85218975
113Inappropriate behavior (HP:0000719)1.84439398
114Congenital stationary night blindness (HP:0007642)1.84334588
115Exotropia (HP:0000577)1.83490016
116Cerebral aneurysm (HP:0004944)1.82710318
117Open mouth (HP:0000194)1.81694389
118Aortic aneurysm (HP:0004942)1.81173291
119Difficulty climbing stairs (HP:0003551)1.81009197
120Hemorrhage of the eye (HP:0011885)1.80978660
121Impaired vibration sensation in the lower limbs (HP:0002166)1.80632816
122Increased cerebral lipofuscin (HP:0011813)1.80093646
123Pointed chin (HP:0000307)1.80033414
124Glucose intolerance (HP:0000833)1.79792016
125Hypercortisolism (HP:0001578)1.79051200
126Large eyes (HP:0001090)1.78295987
127Striae distensae (HP:0001065)1.78146901
128Inability to walk (HP:0002540)1.77348350
129Fragile skin (HP:0001030)1.77028496
130Distal lower limb amyotrophy (HP:0008944)1.75369127
131Broad metatarsal (HP:0001783)1.74501823
132Ankle contracture (HP:0006466)1.74410771
133Shallow orbits (HP:0000586)1.73242327
134Fetal akinesia sequence (HP:0001989)1.72667362
135Vertebral compression fractures (HP:0002953)1.71947428
136Ovoid vertebral bodies (HP:0003300)1.71439934
137Drooling (HP:0002307)1.71243167
138Excessive salivation (HP:0003781)1.71243167
139Aortic regurgitation (HP:0001659)1.70328598
140Abnormality of dentin (HP:0010299)1.70212402
141Postural instability (HP:0002172)1.69341110
142Craniofacial dystonia (HP:0012179)1.68682909
143Eczematoid dermatitis (HP:0000976)1.67149923
144Menorrhagia (HP:0000132)1.66921423
145Iris hypopigmentation (HP:0007730)1.66644096
146Abnormality of complement system (HP:0005339)1.66480999
147Segmental peripheral demyelination/remyelination (HP:0003481)1.66228793
148Dysmetria (HP:0001310)1.66041951
149Abnormality of ocular smooth pursuit (HP:0000617)1.65901274
150Premature rupture of membranes (HP:0001788)1.64036813
151Hyperparathyroidism (HP:0000843)1.62897257
152Abnormality of the distal phalanges of the toes (HP:0010182)1.62719167
153Heterochromia iridis (HP:0001100)1.62375337
154Sleep apnea (HP:0010535)1.62174668
155Flat acetabular roof (HP:0003180)1.60991133
156Hyperacusis (HP:0010780)1.60559923
157Stridor (HP:0010307)1.60178378
158Abnormality of glutamine family amino acid metabolism (HP:0010902)1.60172056
159Wrist flexion contracture (HP:0001239)1.60149141
160Onion bulb formation (HP:0003383)1.60099241
161Coxa vara (HP:0002812)1.58769030
162Neuronal loss in central nervous system (HP:0002529)1.57952363
163Widely spaced teeth (HP:0000687)1.57882413
164Abnormality of the acetabulum (HP:0003170)1.57351689
165Increased neuronal autofluorescent lipopigment (HP:0002074)1.57349260
166Long toe (HP:0010511)1.57193056
167Bradycardia (HP:0001662)1.57001278
168Akinesia (HP:0002304)1.55923174
169Elbow flexion contracture (HP:0002987)1.55795384
170Cardiovascular calcification (HP:0011915)1.55537563
171Bowel diverticulosis (HP:0005222)1.55473372
172Femoral bowing (HP:0002980)1.54912594
173Bradykinesia (HP:0002067)1.54789959
174Scanning speech (HP:0002168)1.54720501
175Overgrowth (HP:0001548)1.54476205
176Deeply set eye (HP:0000490)1.53965350
177Absent frontal sinuses (HP:0002688)1.53449139
178Protruding tongue (HP:0010808)1.53334510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.68563912
2CASK3.61390293
3MAP3K123.36468357
4EPHA43.20969510
5TESK13.10380848
6ERN12.93720638
7MAP2K72.63558183
8MAP3K92.61543918
9MARK12.47681950
10MINK12.30967040
11RIPK42.29471220
12MAP3K42.27327930
13DAPK22.20297654
14LIMK12.14183749
15IRAK32.13973890
16EPHA22.01815724
17TESK21.99088216
18PRPF4B1.97077794
19DAPK11.94467702
20PAK61.94381683
21CAMKK11.80780927
22SIK31.72161005
23TAOK11.68228066
24FES1.67201789
25SIK11.67010661
26MST1R1.66152760
27EPHB11.65124769
28MAP2K31.62409593
29NTRK21.60889200
30CDK191.60411414
31SIK21.59863398
32MAP3K61.59741424
33ZAP701.59231241
34PTK21.53994327
35ICK1.48401893
36CAMKK21.47181200
37LMTK21.44038118
38TNIK1.41736470
39PLK21.40467791
40PAK41.39841392
41CDK51.38566876
42GRK51.38321310
43MAP3K31.36208887
44PTK2B1.34695805
45MOS1.33291701
46MET1.29504464
47MAP3K111.27731246
48MAPK131.27568303
49KSR21.26382694
50TTN1.25473842
51MAP3K131.22217531
52TNK21.19801393
53MAP2K41.16881908
54NTRK11.13779184
55TBK11.12789325
56PRKG21.06607572
57PDPK11.06379271
58TYK21.03608917
59KSR11.02457783
60TAOK21.02094597
61ARAF1.00610545
62NME20.97137376
63MAPKAPK30.95900615
64EPHB20.94550496
65CAMK10.93202323
66BLK0.93194030
67PIM20.91961879
68PRKCH0.91371728
69ABL20.89121932
70MARK20.88501619
71PRKD30.86916800
72PRKCG0.85916974
73STK380.85748960
74FER0.84748705
75ERBB30.83760690
76PDGFRB0.83619360
77MYLK0.83350209
78FLT30.82280089
79CSK0.82225319
80CDK180.81778950
81MAPK150.80809057
82CDK140.78938177
83PKN20.77858892
84CDK150.76218414
85SGK20.75767956
86DAPK30.73237411
87MAP3K140.72285939
88FGFR40.71842432
89RAF10.71311999
90PDK10.69633790
91PTK60.69376703
92SGK4940.68695502
93SGK2230.68695502
94CAMK2A0.68571503
95CDK11A0.67909723
96FYN0.67665459
97PHKG20.67422960
98PHKG10.67422960
99RET0.66999077
100DDR20.64140306
101SGK30.64019527
102PRKCE0.63850345
103RPS6KA20.62680759
104PAK30.62646549
105HCK0.62532670
106JAK10.62481912
107STK110.61938712
108PAK20.61819471
109AKT30.61399646
110DYRK1A0.60930916
111TXK0.60412384
112LATS20.60406151
113MAPK70.59621222
114MAP3K70.58888438
115CCNB10.58821531
116MAP3K10.58444531
117BMPR20.58225253
118KIT0.58125882
119MAP2K10.57528176
120MAP2K60.56875214
121BMX0.56728433
122SMG10.54385957
123PRKD20.54223798
124MAP3K20.54202987
125JAK30.54195645
126CAMK40.53838408
127DYRK1B0.52435292
128GRK70.52157941
129SYK0.51739125
130UHMK10.51535933
131HIPK20.51153845
132NEK90.50779765
133FGR0.49562317
134CAMK2G0.49278217
135CSF1R0.48494830
136CDC42BPA0.48079588
137TRIB30.47918358
138EEF2K0.46256090
139SGK10.46062795
140DMPK0.43580097
141EPHA30.43048202
142PRKD10.42854798
143MAPK120.42635232
144PDK20.41845892
145ROCK20.40119639
146TYRO30.39977456
147GSK3A0.39902968
148SRC0.39676788
149ADRBK20.37292031
150MATK0.36214539
151RIPK10.33164301
152CAMK2B0.32022799
153TGFBR20.31919646
154ADRBK10.30759702
155NEK60.30654449
156PDGFRA0.30595737

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.20174491
2Synaptic vesicle cycle_Homo sapiens_hsa047212.96794991
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.86432682
4Nicotine addiction_Homo sapiens_hsa050332.85289851
5Olfactory transduction_Homo sapiens_hsa047402.23669428
6Morphine addiction_Homo sapiens_hsa050322.17172670
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10930127
8Circadian entrainment_Homo sapiens_hsa047132.06200702
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02409841
10GABAergic synapse_Homo sapiens_hsa047272.02221299
11Glutamatergic synapse_Homo sapiens_hsa047241.78933078
12Collecting duct acid secretion_Homo sapiens_hsa049661.74945027
13Long-term potentiation_Homo sapiens_hsa047201.74865896
14Amphetamine addiction_Homo sapiens_hsa050311.68574238
15Dopaminergic synapse_Homo sapiens_hsa047281.65453729
16Salivary secretion_Homo sapiens_hsa049701.63791688
17Cholinergic synapse_Homo sapiens_hsa047251.59475193
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51918607
19Oxytocin signaling pathway_Homo sapiens_hsa049211.45869479
20Insulin secretion_Homo sapiens_hsa049111.42818054
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41125231
22Renin secretion_Homo sapiens_hsa049241.38950082
23Gastric acid secretion_Homo sapiens_hsa049711.35997862
24Serotonergic synapse_Homo sapiens_hsa047261.35993723
25Taste transduction_Homo sapiens_hsa047421.35354989
26Cocaine addiction_Homo sapiens_hsa050301.35318047
27Calcium signaling pathway_Homo sapiens_hsa040201.30778363
28ECM-receptor interaction_Homo sapiens_hsa045121.26994178
29Vibrio cholerae infection_Homo sapiens_hsa051101.26428269
30Long-term depression_Homo sapiens_hsa047301.24676802
31Pertussis_Homo sapiens_hsa051331.24096506
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22680737
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21736448
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18735911
35Galactose metabolism_Homo sapiens_hsa000521.17659963
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17500022
37GnRH signaling pathway_Homo sapiens_hsa049121.15277285
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14846912
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14187133
40Fructose and mannose metabolism_Homo sapiens_hsa000511.10837743
41Rheumatoid arthritis_Homo sapiens_hsa053231.08478660
42Gap junction_Homo sapiens_hsa045401.07475094
43cAMP signaling pathway_Homo sapiens_hsa040241.06985514
44Axon guidance_Homo sapiens_hsa043601.05327430
45Glioma_Homo sapiens_hsa052141.04458906
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.04044508
47Prion diseases_Homo sapiens_hsa050201.02231613
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99906840
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99081917
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98729853
51Protein digestion and absorption_Homo sapiens_hsa049740.98518433
52Toxoplasmosis_Homo sapiens_hsa051450.97276131
53Renin-angiotensin system_Homo sapiens_hsa046140.96946368
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96421558
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96348046
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95871001
57Phototransduction_Homo sapiens_hsa047440.94862875
58Staphylococcus aureus infection_Homo sapiens_hsa051500.93429027
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.92902396
60ErbB signaling pathway_Homo sapiens_hsa040120.91970845
61Dilated cardiomyopathy_Homo sapiens_hsa054140.91611957
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91553793
63TNF signaling pathway_Homo sapiens_hsa046680.90551694
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89961192
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87581886
66Phagosome_Homo sapiens_hsa041450.87084827
67Malaria_Homo sapiens_hsa051440.86288035
68Estrogen signaling pathway_Homo sapiens_hsa049150.85521618
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.84076512
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.83829854
71MAPK signaling pathway_Homo sapiens_hsa040100.83237206
72Proteoglycans in cancer_Homo sapiens_hsa052050.82124149
73Mineral absorption_Homo sapiens_hsa049780.81803167
74Rap1 signaling pathway_Homo sapiens_hsa040150.80529000
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79587827
76Chemokine signaling pathway_Homo sapiens_hsa040620.79292685
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79289190
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79025709
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.78974784
80Salmonella infection_Homo sapiens_hsa051320.78728677
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77310493
82Complement and coagulation cascades_Homo sapiens_hsa046100.76580603
83Tuberculosis_Homo sapiens_hsa051520.76187408
84Ras signaling pathway_Homo sapiens_hsa040140.75455832
85Bladder cancer_Homo sapiens_hsa052190.74862503
86Sphingolipid metabolism_Homo sapiens_hsa006000.74752073
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74667481
88Osteoclast differentiation_Homo sapiens_hsa043800.74238585
89VEGF signaling pathway_Homo sapiens_hsa043700.74068114
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73819914
91Melanogenesis_Homo sapiens_hsa049160.72837313
92Endocytosis_Homo sapiens_hsa041440.71676254
93Type I diabetes mellitus_Homo sapiens_hsa049400.71420094
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71287813
95Platelet activation_Homo sapiens_hsa046110.71078464
96Shigellosis_Homo sapiens_hsa051310.70139967
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70133250
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69662826
99Colorectal cancer_Homo sapiens_hsa052100.69027864
100Type II diabetes mellitus_Homo sapiens_hsa049300.68647327
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67701032
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67186189
103PPAR signaling pathway_Homo sapiens_hsa033200.66952896
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65296658
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.65197621
106Lysosome_Homo sapiens_hsa041420.65192372
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65011337
108Acute myeloid leukemia_Homo sapiens_hsa052210.64763437
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62967650
110Hepatitis C_Homo sapiens_hsa051600.62651323
111Choline metabolism in cancer_Homo sapiens_hsa052310.62432616
112Leishmaniasis_Homo sapiens_hsa051400.61439856
113Melanoma_Homo sapiens_hsa052180.60985157
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.60227036
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59897123
116Renal cell carcinoma_Homo sapiens_hsa052110.58855314
117Focal adhesion_Homo sapiens_hsa045100.58823867
118Pancreatic secretion_Homo sapiens_hsa049720.58634982
119Endometrial cancer_Homo sapiens_hsa052130.58240221
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.57388476
121T cell receptor signaling pathway_Homo sapiens_hsa046600.56023734
122Pancreatic cancer_Homo sapiens_hsa052120.54885016
123B cell receptor signaling pathway_Homo sapiens_hsa046620.54809346
124Prolactin signaling pathway_Homo sapiens_hsa049170.54602028
125Apoptosis_Homo sapiens_hsa042100.53299488
126Hematopoietic cell lineage_Homo sapiens_hsa046400.52895434
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52316111
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52253863
129Pentose phosphate pathway_Homo sapiens_hsa000300.52203157
130Inositol phosphate metabolism_Homo sapiens_hsa005620.52098457
131Amoebiasis_Homo sapiens_hsa051460.51720895
132Viral myocarditis_Homo sapiens_hsa054160.49221818
133Bile secretion_Homo sapiens_hsa049760.48812508
134Non-small cell lung cancer_Homo sapiens_hsa052230.48735541
135Chronic myeloid leukemia_Homo sapiens_hsa052200.48107074
136Influenza A_Homo sapiens_hsa051640.47954270
137Notch signaling pathway_Homo sapiens_hsa043300.47591945
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47055730
139Histidine metabolism_Homo sapiens_hsa003400.46340381

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