SFT2D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.95243075
2ATP synthesis coupled proton transport (GO:0015986)5.22821134
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.22821134
4neutrophil activation involved in immune response (GO:0002283)5.10428854
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.78409536
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.71978611
7respiratory electron transport chain (GO:0022904)4.48201586
8electron transport chain (GO:0022900)4.37010589
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.27515331
10respiratory burst (GO:0045730)4.20038209
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.19269472
12protein complex biogenesis (GO:0070271)3.87993569
13positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.87899500
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.84973266
15mitochondrial respiratory chain complex I assembly (GO:0032981)3.84973266
16NADH dehydrogenase complex assembly (GO:0010257)3.84973266
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.83041547
18negative regulation of ligase activity (GO:0051352)3.81503378
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.81503378
20regulation of cellular amino acid metabolic process (GO:0006521)3.75848797
21mitochondrial respiratory chain complex assembly (GO:0033108)3.73547291
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.71765626
23oxidative phosphorylation (GO:0006119)3.65673382
24mast cell activation (GO:0045576)3.62398372
25protein targeting to mitochondrion (GO:0006626)3.62103002
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.61624020
27positive regulation of B cell differentiation (GO:0045579)3.61037996
28respiratory chain complex IV assembly (GO:0008535)3.60762246
29DNA deamination (GO:0045006)3.60253066
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.59481282
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.58227952
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54962668
33immunoglobulin mediated immune response (GO:0016064)3.54138434
34pseudouridine synthesis (GO:0001522)3.53080593
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51469979
36signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51469979
37signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.51103923
38signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.51103923
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.51103923
40rRNA modification (GO:0000154)3.46115987
41cytochrome complex assembly (GO:0017004)3.43751201
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.36570789
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.36570789
44positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.36324005
45deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36064624
46positive regulation of gamma-delta T cell activation (GO:0046645)3.35391592
47regulation of mitochondrial translation (GO:0070129)3.34842263
48cellular response to interferon-beta (GO:0035458)3.34143094
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.33852110
50positive regulation by organism of defense response of other organism involved in symbiotic interact3.33852110
51modulation by symbiont of host immune response (GO:0052553)3.33852110
52positive regulation by symbiont of host defense response (GO:0052509)3.33852110
53modulation by symbiont of host defense response (GO:0052031)3.33852110
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.33852110
55defense response to protozoan (GO:0042832)3.33817169
56signal transduction involved in cell cycle checkpoint (GO:0072395)3.30095319
57neutrophil activation (GO:0042119)3.28580710
58establishment of protein localization to mitochondrion (GO:0072655)3.28479969
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.28160187
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.28160187
61CENP-A containing nucleosome assembly (GO:0034080)3.27963148
62protein localization to mitochondrion (GO:0070585)3.26786027
63positive regulation of ligase activity (GO:0051351)3.24701675
64ribosomal large subunit biogenesis (GO:0042273)3.24670840
65granulocyte activation (GO:0036230)3.16609962
66purine nucleobase biosynthetic process (GO:0009113)3.15668475
67myeloid cell activation involved in immune response (GO:0002275)3.14104786
68microglial cell activation (GO:0001774)3.13977087
69chromatin remodeling at centromere (GO:0031055)3.13041630
70positive regulation of chemokine secretion (GO:0090197)3.11721454
71response to interferon-beta (GO:0035456)3.08279721
72regulation of B cell receptor signaling pathway (GO:0050855)3.05721684
73ATP biosynthetic process (GO:0006754)3.05270155
74response to protozoan (GO:0001562)3.04580293
75termination of RNA polymerase III transcription (GO:0006386)3.03915267
76transcription elongation from RNA polymerase III promoter (GO:0006385)3.03915267
77leukocyte aggregation (GO:0070486)3.02799306
78response to peptidoglycan (GO:0032494)3.02248186
79purine nucleotide salvage (GO:0032261)3.02185665
80establishment of integrated proviral latency (GO:0075713)2.98012363
81regulation of B cell differentiation (GO:0045577)2.97916982
82protein maturation by protein folding (GO:0022417)2.97177156
83regulation of interferon-beta biosynthetic process (GO:0045357)2.96591201
84ribosomal small subunit assembly (GO:0000028)2.96384631
85regulation of ubiquitin-protein transferase activity (GO:0051438)2.94020932
86deoxyribose phosphate catabolic process (GO:0046386)2.92197455
87aerobic respiration (GO:0009060)2.92139726
88pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.90704600
89B cell receptor signaling pathway (GO:0050853)2.90169831
90ribosome assembly (GO:0042255)2.89718885
91cullin deneddylation (GO:0010388)2.89646609
92purine nucleoside triphosphate biosynthetic process (GO:0009145)2.89335258
93cellular response to exogenous dsRNA (GO:0071360)2.89049373
94leukocyte degranulation (GO:0043299)2.88736369
95axon ensheathment in central nervous system (GO:0032291)2.88254210
96central nervous system myelination (GO:0022010)2.88254210
97hydrogen ion transmembrane transport (GO:1902600)2.87214663
98protein deneddylation (GO:0000338)2.86897614
99translation (GO:0006412)2.86851978
100deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.86533134
101regulation of ligase activity (GO:0051340)2.86113299
102purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.85578447
103positive regulation of antigen processing and presentation (GO:0002579)2.83225688
104establishment of viral latency (GO:0019043)2.82634292
105amyloid precursor protein catabolic process (GO:0042987)2.82597819
106positive regulation of interferon-alpha production (GO:0032727)2.82426167
107antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80774761
108regulation of cellular amine metabolic process (GO:0033238)2.80440085
109phagocytosis, engulfment (GO:0006911)2.80259223
110macrophage activation involved in immune response (GO:0002281)2.80134062
111mitochondrial transport (GO:0006839)2.79371777
112response to muramyl dipeptide (GO:0032495)2.79058673
113pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.75065806
114DNA catabolic process, exonucleolytic (GO:0000738)2.74648031
115deoxyribonucleotide catabolic process (GO:0009264)2.74482589
116spliceosomal snRNP assembly (GO:0000387)2.74314685
117purine-containing compound salvage (GO:0043101)2.73793767
118Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73704849
119positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73664674
120maturation of SSU-rRNA (GO:0030490)2.72833165
121negative regulation of protein ubiquitination (GO:0031397)2.72620948
122purine nucleoside monophosphate biosynthetic process (GO:0009127)2.72440693
123purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.72440693
124antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72336809
125DNA replication checkpoint (GO:0000076)2.71474927
126DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.71365866
127T cell migration (GO:0072678)2.69937808
128regulation of interferon-alpha production (GO:0032647)2.69081287
129negative regulation of myeloid cell apoptotic process (GO:0033033)2.68472875
130histone mRNA metabolic process (GO:0008334)2.67980177
131proteasome assembly (GO:0043248)2.66792885
132rRNA processing (GO:0006364)2.65484702
133positive regulation of cell cycle arrest (GO:0071158)2.65293884
134production of molecular mediator involved in inflammatory response (GO:0002532)2.65163332
135protein-cofactor linkage (GO:0018065)2.64566098
136antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.64565907
137antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.64565907
138positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.64339203
139B cell mediated immunity (GO:0019724)2.63432691
140antigen processing and presentation of endogenous antigen (GO:0019883)2.62833451
141cellular component biogenesis (GO:0044085)2.62694993
142signal peptide processing (GO:0006465)2.62337599
143nucleobase biosynthetic process (GO:0046112)2.61140335
144amyloid precursor protein metabolic process (GO:0042982)2.59060514
145IMP biosynthetic process (GO:0006188)2.58684176
146myeloid leukocyte activation (GO:0002274)2.57825112
147G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.55290363
148fatty acid elongation (GO:0030497)2.53897161
149L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52290058
150myeloid dendritic cell activation (GO:0001773)2.50944265
151platelet dense granule organization (GO:0060155)2.50750819
152positive regulation of interleukin-17 production (GO:0032740)2.50671098
153regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.46891232
154regulation of antigen processing and presentation (GO:0002577)2.46446837
155regulation of interleukin-17 production (GO:0032660)2.46286490
156regulation of lymphocyte migration (GO:2000401)2.44237038
157GPI anchor biosynthetic process (GO:0006506)2.42483965
158regulation of T cell migration (GO:2000404)2.41950588
159positive regulation of alpha-beta T cell proliferation (GO:0046641)2.39802814
160T-helper 1 type immune response (GO:0042088)2.38139063
161protein neddylation (GO:0045116)2.38038397
162negative regulation of interleukin-17 production (GO:0032700)2.37303707
163lipopolysaccharide-mediated signaling pathway (GO:0031663)2.36490772
164positive regulation of mast cell activation (GO:0033005)2.34823662
165sequestering of actin monomers (GO:0042989)2.34707471
166macrophage activation (GO:0042116)2.34332162
167NIK/NF-kappaB signaling (GO:0038061)2.34246208
168ribosomal small subunit biogenesis (GO:0042274)2.33519437
169aldehyde catabolic process (GO:0046185)2.32788657
170positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.31631518
171chaperone-mediated protein transport (GO:0072321)2.31073665
172regulation of mast cell activation (GO:0033003)2.29157013
173positive regulation of T cell mediated cytotoxicity (GO:0001916)2.28863160
174regulation of alpha-beta T cell proliferation (GO:0046640)2.28616619
175superoxide anion generation (GO:0042554)2.27391933
176mast cell degranulation (GO:0043303)2.26359145
177mast cell activation involved in immune response (GO:0002279)2.26359145
178positive regulation of lymphocyte migration (GO:2000403)2.25047479
179antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.24476196
180myeloid dendritic cell differentiation (GO:0043011)2.23974162
181type I interferon signaling pathway (GO:0060337)2.23192920
182cellular response to type I interferon (GO:0071357)2.23192920
183preassembly of GPI anchor in ER membrane (GO:0016254)2.22142665
184cellular extravasation (GO:0045123)2.21176778
185membrane invagination (GO:0010324)2.21146600
186positive regulation of mast cell activation involved in immune response (GO:0033008)2.20167499
187positive regulation of mast cell degranulation (GO:0043306)2.20167499
188glycosphingolipid catabolic process (GO:0046479)2.19680363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.79249519
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.27234511
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.26834111
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94873089
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.65748253
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19452501
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.08955987
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.05978753
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.02829341
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.95242796
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83982240
12* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.70679509
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.70431965
14SCL_19346495_ChIP-Seq_HPC-7_Human2.59945188
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57569845
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.49864785
17SPI1_23547873_ChIP-Seq_NB4_Human2.47047648
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44901038
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43428769
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42012029
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38256636
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35631733
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.31269229
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.28226051
25* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14594507
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13926836
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11339091
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.06451302
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.06228800
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.94590240
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92284073
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90867578
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89367646
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86401509
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85268185
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83385744
37ERG_20887958_ChIP-Seq_HPC-7_Mouse1.81759743
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81348532
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78725693
40VDR_23849224_ChIP-Seq_CD4+_Human1.77976966
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77520384
42* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74926719
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72105632
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.71775244
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.70497811
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.67840255
47* VDR_24763502_ChIP-Seq_THP-1_Human1.67772724
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66685254
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64604227
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63565128
51RUNX_20019798_ChIP-Seq_JUKART_Human1.61410023
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61192815
53TTF2_22483619_ChIP-Seq_HELA_Human1.58033483
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57262706
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56756326
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56156822
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54536192
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52468198
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.51246579
60VDR_21846776_ChIP-Seq_THP-1_Human1.50854755
61* MYB_26560356_Chip-Seq_TH2_Human1.49751723
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48635885
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48374346
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45937749
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43706806
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43619038
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42902168
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41386990
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40321803
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38711661
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35794383
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35506799
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34837590
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33194468
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32552822
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32121371
77MYC_18940864_ChIP-ChIP_HL60_Human1.32018806
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31589451
79FOXP3_21729870_ChIP-Seq_TREG_Human1.31564252
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31418372
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.31353653
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30370646
83TFEB_21752829_ChIP-Seq_HELA_Human1.29893460
84* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27952386
85* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27603098
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26661779
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26336783
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25562134
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22999314
90MYB_26560356_Chip-Seq_TH1_Human1.22663899
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.21732454
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21646395
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21605563
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21421834
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20859359
96MAF_26560356_Chip-Seq_TH1_Human1.20152994
97ELK1_19687146_ChIP-ChIP_HELA_Human1.19405498
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19094060
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18631284
100MYC_18555785_ChIP-Seq_MESCs_Mouse1.18370535
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17863367
102PU_27001747_Chip-Seq_BMDM_Mouse1.16302589
103DCP1A_22483619_ChIP-Seq_HELA_Human1.13451442
104MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13267151
105CIITA_25753668_ChIP-Seq_RAJI_Human1.10759977
106E2F1_21310950_ChIP-Seq_MCF-7_Human1.09220503
107MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09069431
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09015574
109GATA3_26560356_Chip-Seq_TH2_Human1.08994790
110* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08110658
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07836718
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.06192947
113NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04234989
114GATA3_27048872_Chip-Seq_THYMUS_Human1.02469368
115SPI1_23127762_ChIP-Seq_K562_Human1.00238767
116PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99676440
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98192169
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96673379
119MAF_26560356_Chip-Seq_TH2_Human0.96499620
120ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95937791
121* GABP_19822575_ChIP-Seq_HepG2_Human0.93902470
122ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93740550
123E2F7_22180533_ChIP-Seq_HELA_Human0.93140025
124MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92605903
125GATA1_22025678_ChIP-Seq_K562_Human0.92229465
126UTX_26944678_Chip-Seq_JUKART_Human0.92054814
127KDM5A_27292631_Chip-Seq_BREAST_Human0.91293615
128XRN2_22483619_ChIP-Seq_HELA_Human0.91273308
129STAT1_20625510_ChIP-Seq_HELA_Human0.90992613
130* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88423696
131FLI1_27457419_Chip-Seq_LIVER_Mouse0.80329309
132PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80182776
133ELF5_23300383_ChIP-Seq_T47D_Human0.78431767
134EWS_26573619_Chip-Seq_HEK293_Human0.76462769
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73076442
136ZNF274_21170338_ChIP-Seq_K562_Hela0.72989823
137AR_20517297_ChIP-Seq_VCAP_Human0.72985401
138AR_21909140_ChIP-Seq_LNCAP_Human0.72935196
139SALL4_22934838_ChIP-ChIP_CD34+_Human0.70034642
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69397002
141FOXM1_23109430_ChIP-Seq_U2OS_Human0.69098770
142FOXA1_27270436_Chip-Seq_PROSTATE_Human0.67355780
143FOXA1_25329375_ChIP-Seq_VCAP_Human0.67355780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.00013951
2MP0006082_CNS_inflammation3.49390790
3MP0005671_abnormal_response_to3.19691760
4MP0009785_altered_susceptibility_to3.19594918
5MP0002148_abnormal_hypersensitivity_rea3.00565671
6MP0003436_decreased_susceptibility_to2.99818196
7MP0002419_abnormal_innate_immunity2.93076193
8MP0005000_abnormal_immune_tolerance2.84662172
9MP0006036_abnormal_mitochondrial_physio2.83339686
10MP0003724_increased_susceptibility_to2.81585084
11MP0005058_abnormal_lysosome_morphology2.77923571
12MP0005025_abnormal_response_to2.70331501
13MP0008058_abnormal_DNA_repair2.62455020
14MP0001800_abnormal_humoral_immune2.55403238
15MP0002452_abnormal_antigen_presenting2.52708087
16MP0002723_abnormal_immune_serum2.48729630
17MP0010094_abnormal_chromosome_stability2.48181933
18MP0005464_abnormal_platelet_physiology2.44903382
19MP0000685_abnormal_immune_system2.42343548
20MP0005387_immune_system_phenotype2.37894996
21MP0001790_abnormal_immune_system2.37894996
22MP0009840_abnormal_foam_cell2.37051547
23MP0003191_abnormal_cellular_cholesterol2.36317351
24MP0004957_abnormal_blastocyst_morpholog2.35755126
25MP0002420_abnormal_adaptive_immunity2.34194415
26MP0001819_abnormal_immune_cell2.32712609
27MP0000920_abnormal_myelination2.12026257
28MP0006035_abnormal_mitochondrial_morpho2.11892832
29MP0003786_premature_aging2.09909584
30MP0009333_abnormal_splenocyte_physiolog2.04166426
31MP0003111_abnormal_nucleus_morphology1.95800145
32MP0001853_heart_inflammation1.86292742
33MP0002396_abnormal_hematopoietic_system1.85459103
34MP0000716_abnormal_immune_system1.81635269
35MP0002398_abnormal_bone_marrow1.79011418
36MP0008007_abnormal_cellular_replicative1.77477247
37MP0002405_respiratory_system_inflammati1.77212614
38MP0005084_abnormal_gallbladder_morpholo1.77124135
39MP0003763_abnormal_thymus_physiology1.75322614
40MP0000689_abnormal_spleen_morphology1.72972568
41MP0009697_abnormal_copulation1.72574127
42MP0006054_spinal_hemorrhage1.69448449
43MP0001986_abnormal_taste_sensitivity1.68530479
44MP0003077_abnormal_cell_cycle1.67261251
45MP0001533_abnormal_skeleton_physiology1.66999913
46MP0001845_abnormal_inflammatory_respons1.65919002
47MP0008469_abnormal_protein_level1.64324564
48MP0005075_abnormal_melanosome_morpholog1.63371386
49MP0003656_abnormal_erythrocyte_physiolo1.62272411
50MP0003186_abnormal_redox_activity1.62112504
51MP0003806_abnormal_nucleotide_metabolis1.61015829
52MP0003690_abnormal_glial_cell1.58346808
53MP0000465_gastrointestinal_hemorrhage1.57553210
54MP0002429_abnormal_blood_cell1.53194980
55MP0010155_abnormal_intestine_physiology1.51730574
56MP0001873_stomach_inflammation1.49362326
57MP0005451_abnormal_body_composition1.48994339
58MP0002722_abnormal_immune_system1.48221254
59MP0003303_peritoneal_inflammation1.45294373
60MP0009764_decreased_sensitivity_to1.43050319
61MP0002166_altered_tumor_susceptibility1.41548558
62MP0008260_abnormal_autophagy1.40227506
63MP0002933_joint_inflammation1.37717132
64MP0000343_altered_response_to1.35529684
65MP0003172_abnormal_lysosome_physiology1.33474177
66MP0005174_abnormal_tail_pigmentation1.32166484
67MP0008932_abnormal_embryonic_tissue1.30431142
68MP0002006_tumorigenesis1.30099627
69MP0001545_abnormal_hematopoietic_system1.29995091
70MP0005397_hematopoietic_system_phenotyp1.29995091
71MP0003075_altered_response_to1.27034065
72MP0000358_abnormal_cell_content/1.26051537
73MP0004147_increased_porphyrin_level1.24592703
74MP0003195_calcinosis1.22450402
75MP0002102_abnormal_ear_morphology1.19429156
76MP0002277_abnormal_respiratory_mucosa1.18617743
77MP0005310_abnormal_salivary_gland1.17337605
78MP0003866_abnormal_defecation1.08545690
79MP0003183_abnormal_peptide_metabolism1.08468272
80MP0008872_abnormal_physiological_respon1.07283784
81MP0004947_skin_inflammation1.07279225
82MP0000858_altered_metastatic_potential1.06802605
83MP0002132_abnormal_respiratory_system1.05213505
84MP0001764_abnormal_homeostasis1.04949298
85MP0000490_abnormal_crypts_of1.03667498
86MP0000015_abnormal_ear_pigmentation1.03354989
87MP0002163_abnormal_gland_morphology1.03055711
88MP0004510_myositis1.01701605
89MP0000604_amyloidosis1.01463450
90MP0000313_abnormal_cell_death0.99913209
91MP0005166_decreased_susceptibility_to0.98342952
92MP0001851_eye_inflammation0.96290423
93MP0009763_increased_sensitivity_to0.95999710
94MP0000372_irregular_coat_pigmentation0.95399024
95MP0009278_abnormal_bone_marrow0.92416972
96MP0008057_abnormal_DNA_replication0.92117599
97MP0005636_abnormal_mineral_homeostasis0.90512917
98MP0004381_abnormal_hair_follicle0.90355177
99MP0003011_delayed_dark_adaptation0.89469314
100MP0005408_hypopigmentation0.88703294
101MP0004782_abnormal_surfactant_physiolog0.88634410
102MP0008875_abnormal_xenobiotic_pharmacok0.88514613
103MP0005319_abnormal_enzyme/_coenzyme0.88209570
104MP0003693_abnormal_embryo_hatching0.87746797
105MP0005165_increased_susceptibility_to0.85054118
106MP0003950_abnormal_plasma_membrane0.84834857
107MP0001905_abnormal_dopamine_level0.83971437
108MP0008873_increased_physiological_sensi0.83303660
109MP0000703_abnormal_thymus_morphology0.82673452
110MP0005584_abnormal_enzyme/coenzyme_acti0.82620620
111MP0005332_abnormal_amino_acid0.81757620
112MP0002998_abnormal_bone_remodeling0.81693340
113MP0002138_abnormal_hepatobiliary_system0.81065923
114MP0005164_abnormal_response_to0.79890316
115MP0003448_altered_tumor_morphology0.79552712
116MP0005409_darkened_coat_color0.78900007
117MP0006292_abnormal_olfactory_placode0.76291799
118MP0005171_absent_coat_pigmentation0.75553986
119MP0001542_abnormal_bone_strength0.75317851
120MP0001529_abnormal_vocalization0.75051682
121MP0004883_abnormal_blood_vessel0.73922187
122MP0009765_abnormal_xenobiotic_induced0.73710348
123MP0002736_abnormal_nociception_after0.73392693
124MP0009379_abnormal_foot_pigmentation0.73227945
125MP0008877_abnormal_DNA_methylation0.70019909
126MP0003136_yellow_coat_color0.69287548
127MP0004142_abnormal_muscle_tone0.69263445
128MP0000249_abnormal_blood_vessel0.68329127
129MP0001663_abnormal_digestive_system0.66876370
130MP0005390_skeleton_phenotype0.65496735
131MP0002019_abnormal_tumor_incidence0.61536200
132MP0003718_maternal_effect0.59617914
133MP0002095_abnormal_skin_pigmentation0.58699561

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.52101604
2Acute necrotizing encephalopathy (HP:0006965)5.32207185
3Recurrent bacterial skin infections (HP:0005406)4.98172224
4Abnormal mitochondria in muscle tissue (HP:0008316)4.93837948
5Mitochondrial inheritance (HP:0001427)4.83311273
6Acute encephalopathy (HP:0006846)4.71144862
7Increased CSF lactate (HP:0002490)4.54048876
8Progressive macrocephaly (HP:0004481)4.47106160
9Eczematoid dermatitis (HP:0000976)4.21635104
10Elevated erythrocyte sedimentation rate (HP:0003565)4.16559696
11Vacuolated lymphocytes (HP:0001922)4.14366387
12Systemic lupus erythematosus (HP:0002725)3.95838210
13Abnormality of macrophages (HP:0004311)3.77264190
14Increased hepatocellular lipid droplets (HP:0006565)3.60666174
15Recurrent gram-negative bacterial infections (HP:0005420)3.59892292
16Cerebral edema (HP:0002181)3.55934075
17Recurrent skin infections (HP:0001581)3.54983838
18Lipid accumulation in hepatocytes (HP:0006561)3.49403839
19Hepatosplenomegaly (HP:0001433)3.38942787
20Myositis (HP:0100614)3.33990430
21Chronic otitis media (HP:0000389)3.20917012
22Glomerulonephritis (HP:0000099)3.19492276
23IgM deficiency (HP:0002850)3.19215835
24Abnormality of glycolipid metabolism (HP:0010969)3.14893798
25Abnormality of liposaccharide metabolism (HP:0010968)3.14893798
26Abnormality of glycosphingolipid metabolism (HP:0004343)3.14893798
27Increased serum lactate (HP:0002151)3.14016151
28Stomatitis (HP:0010280)3.09589251
29Petechiae (HP:0000967)3.07926958
30Respiratory failure (HP:0002878)3.07667783
31Lactic acidosis (HP:0003128)3.06925849
32Increased intramyocellular lipid droplets (HP:0012240)3.02764483
33Axonal loss (HP:0003447)3.01371127
34Obstructive lung disease (HP:0006536)2.99522298
35Chronic obstructive pulmonary disease (HP:0006510)2.99522298
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.93116514
37Increased serum pyruvate (HP:0003542)2.86267259
38Mediastinal lymphadenopathy (HP:0100721)2.84603888
39Purpura (HP:0000979)2.78965521
40Recurrent fungal infections (HP:0002841)2.76491547
413-Methylglutaconic aciduria (HP:0003535)2.73275918
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69988734
43Congenital, generalized hypertrichosis (HP:0004540)2.69627598
44Increased muscle lipid content (HP:0009058)2.67416560
45Increased cerebral lipofuscin (HP:0011813)2.64137838
46Recurrent viral infections (HP:0004429)2.59602013
47Vasculitis (HP:0002633)2.58865245
48Dysostosis multiplex (HP:0000943)2.58737916
49Meningitis (HP:0001287)2.56107732
50Abnormality of glycolysis (HP:0004366)2.52799414
51Exercise intolerance (HP:0003546)2.52466958
52Cerebral hypomyelination (HP:0006808)2.48768535
53Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48401581
54CNS demyelination (HP:0007305)2.43212683
55Lethargy (HP:0001254)2.42567007
56Gastrointestinal stroma tumor (HP:0100723)2.42513913
57Leukodystrophy (HP:0002415)2.42170486
58Macrocytic anemia (HP:0001972)2.39234844
59Autoimmune thrombocytopenia (HP:0001973)2.38374900
60Abnormality of cells of the erythroid lineage (HP:0012130)2.36854106
61Pustule (HP:0200039)2.36102451
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32908281
63Abnormality of alanine metabolism (HP:0010916)2.32908281
64Hyperalaninemia (HP:0003348)2.32908281
65Abnormal protein glycosylation (HP:0012346)2.32868066
66Abnormal glycosylation (HP:0012345)2.32868066
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32868066
68Abnormal protein N-linked glycosylation (HP:0012347)2.32868066
69Abnormality of methionine metabolism (HP:0010901)2.32783013
70Microvesicular hepatic steatosis (HP:0001414)2.32104960
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30361344
72Abnormality of B cell number (HP:0010975)2.30356245
73Respiratory difficulties (HP:0002880)2.30256222
74Optic neuritis (HP:0100653)2.30163110
75Retrobulbar optic neuritis (HP:0100654)2.30163110
76Recurrent pneumonia (HP:0006532)2.29843436
77Abnormal number of erythroid precursors (HP:0012131)2.29722328
78Optic disc pallor (HP:0000543)2.28861481
79Panhypogammaglobulinemia (HP:0003139)2.28630526
80Orchitis (HP:0100796)2.27488538
81Thrombocytosis (HP:0001894)2.27333861
82Cellulitis (HP:0100658)2.27152486
83Degeneration of anterior horn cells (HP:0002398)2.26888849
84Abnormality of the anterior horn cell (HP:0006802)2.26888849
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26154576
86B lymphocytopenia (HP:0010976)2.24183072
87Progressive neurologic deterioration (HP:0002344)2.21185031
88Prolonged neonatal jaundice (HP:0006579)2.20858559
89Recurrent cutaneous fungal infections (HP:0011370)2.20727120
90Chronic mucocutaneous candidiasis (HP:0002728)2.20727120
91Parakeratosis (HP:0001036)2.20310432
92Poor head control (HP:0002421)2.20205549
93Agnosia (HP:0010524)2.20021976
94Exertional dyspnea (HP:0002875)2.19229740
95Basal ganglia calcification (HP:0002135)2.19016697
96Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18534598
97Methylmalonic acidemia (HP:0002912)2.17950801
98Methylmalonic aciduria (HP:0012120)2.17126546
99Nausea (HP:0002018)2.16903808
100Lymphopenia (HP:0001888)2.16843440
101Leukocytosis (HP:0001974)2.16138327
102Increased IgM level (HP:0003496)2.15513784
103Pancytopenia (HP:0001876)2.14102755
104Reduced antithrombin III activity (HP:0001976)2.13121198
105Abnormality of aromatic amino acid family metabolism (HP:0004338)2.12024580
106Eosinophilia (HP:0001880)2.11126878
107Abnormality of T cell physiology (HP:0011840)2.10993561
108Amyloidosis (HP:0011034)2.10517480
109Epistaxis (HP:0000421)2.09803575
110Testicular atrophy (HP:0000029)2.09416932
111Chronic diarrhea (HP:0002028)2.08416566
112Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08231080
113Abnormality of T cells (HP:0002843)2.07390113
114Neutropenia (HP:0001875)2.07327856
115Abnormality of eosinophils (HP:0001879)2.06306069
116Urticaria (HP:0001025)2.06270027
117Prolonged bleeding time (HP:0003010)2.05972448
118IgG deficiency (HP:0004315)2.05670579
119Granulocytopenia (HP:0001913)2.05202331
120Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04025968
121Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04025968
122Emotional lability (HP:0000712)2.04021003
123Generalized aminoaciduria (HP:0002909)2.03891367
124Thoracic kyphosis (HP:0002942)2.03673342
125Type I transferrin isoform profile (HP:0003642)2.03047940
126Abnormality of cells of the lymphoid lineage (HP:0012140)2.02465646
127Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.01653339
128Oral leukoplakia (HP:0002745)2.01127241
129Hypergammaglobulinemia (HP:0010702)2.00456143
130Complement deficiency (HP:0004431)2.00235631
131Impaired platelet aggregation (HP:0003540)1.99439458
132Abnormal platelet function (HP:0011869)1.99439458
133Abnormal spermatogenesis (HP:0008669)1.98707209
134Hepatocellular necrosis (HP:0001404)1.98606528
135Short middle phalanx of the 5th finger (HP:0004220)1.97556178
136Abnormality of renal resorption (HP:0011038)1.97475942
137Aplastic anemia (HP:0001915)1.96784832
138Rough bone trabeculation (HP:0100670)1.96433580
139Loss of speech (HP:0002371)1.95920812
140Encephalitis (HP:0002383)1.95742646
141Gingival bleeding (HP:0000225)1.94894802
142Inflammation of the large intestine (HP:0002037)1.93699330
143Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92926806
144Recurrent lower respiratory tract infections (HP:0002783)1.92862769
145Patchy hypopigmentation of hair (HP:0011365)1.92396487
146Recurrent bronchitis (HP:0002837)1.90965177
147Renal Fanconi syndrome (HP:0001994)1.90922086
148Abnormality of the heme biosynthetic pathway (HP:0010472)1.89540223
149Abnormality of serum amino acid levels (HP:0003112)1.89284562
150Pallor (HP:0000980)1.88926338
151Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88388397
152Dicarboxylic aciduria (HP:0003215)1.88388397
153Sparse eyelashes (HP:0000653)1.87752631
154Gingivitis (HP:0000230)1.87248113
155Abnormality of T cell number (HP:0011839)1.87152524
156Osteomyelitis (HP:0002754)1.85075134
157Agammaglobulinemia (HP:0004432)1.84497958
158Lymphoma (HP:0002665)1.81119098
159Severe combined immunodeficiency (HP:0004430)1.79894696
160Hepatic necrosis (HP:0002605)1.79454516
161Autoimmune hemolytic anemia (HP:0001890)1.78040121
162X-linked dominant inheritance (HP:0001423)1.74513233
163Constricted visual fields (HP:0001133)1.71878419
164Abnormality of the prostate (HP:0008775)1.70972904
165Pancreatic islet-cell hyperplasia (HP:0004510)1.70487837
166Spastic paraparesis (HP:0002313)1.68433890
167Azoospermia (HP:0000027)1.67514944
168Reticulocytopenia (HP:0001896)1.66009951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.60038678
2VRK23.39617361
3BLK2.77426122
4NME22.72355285
5TXK2.72123113
6MAP3K142.56154472
7IRAK42.47452347
8NEK12.38604493
9TGFBR22.38510120
10PBK2.35776378
11KIT2.32480648
12TBK12.31426461
13MAP4K22.26536089
14CSF1R2.24605267
15CLK12.18054257
16STK162.14630743
17PIM22.07713211
18TYK22.02950406
19MST41.99137078
20SRPK11.94122886
21TLK11.93210462
22KDR1.91706677
23ZAK1.89181160
24IKBKE1.87554363
25ZAP701.83571288
26BUB11.78503133
27TEC1.77369764
28IKBKB1.73400047
29PDK21.72151850
30TESK21.66899013
31CDC71.60985385
32RIPK41.60955805
33NUAK11.59981351
34BTK1.56428582
35EPHB11.53192377
36IRAK31.51972120
37GRK71.46938435
38TNIK1.36554918
39SCYL21.35539064
40ARAF1.34952781
41VRK11.30174382
42LYN1.29504706
43SYK1.27451172
44TRIM281.27326157
45STK101.22792366
46MOS1.22723502
47BMPR21.21260355
48LCK1.19836107
49JAK31.18400596
50CDK191.18366326
51ITK1.17541994
52PLK31.16330482
53CAMKK21.15054185
54MAPKAPK51.12569665
55MAP3K121.08869856
56ADRBK21.07500021
57STK391.03766064
58DAPK11.00763178
59EIF2AK10.99972977
60LIMK10.99214404
61OXSR10.98293923
62HCK0.96703423
63ILK0.95219009
64MKNK10.93568483
65EIF2AK30.90406786
66CSK0.89497538
67FES0.88963449
68MAP3K130.87795435
69MAPK150.87406125
70NME10.85631762
71PAK40.85614988
72WEE10.83051387
73PIM10.82554239
74CSNK1G30.80068889
75BCKDK0.79776856
76PLK10.79598283
77NLK0.78581302
78ABL20.78490436
79BRSK20.77612787
80TTK0.77083450
81GRK10.75817990
82MUSK0.75771607
83DYRK20.75570747
84BMPR1B0.75218334
85PLK20.71457860
86CDK80.70249287
87EIF2AK20.69667616
88MKNK20.68389845
89AURKB0.67870178
90TESK10.67327290
91TAOK30.67019002
92MAP3K110.64364581
93ACVR1B0.63875451
94ERBB30.61588495
95CSNK2A10.60471257
96ERN10.58882402
97TRPM70.57888393
98CSNK1A1L0.57479792
99FGR0.57404559
100STK40.56253687
101MAPK40.54857762
102CSNK2A20.54019385
103DAPK30.53811916
104MATK0.53598372
105ATR0.53268324
106INSRR0.53228996
107PRKCQ0.51691081
108JAK10.51662037
109PLK40.51084095
110CSNK1G10.51068476
111TNK20.50859318
112PIK3CG0.50259572
113PKN10.48627660
114MYLK0.48344730
115LRRK20.48036487
116NEK60.47017331
117PRKCD0.45939290
118YES10.45830040
119RPS6KA50.45403604
120TIE10.44067539
121MAP2K30.43792363
122MAPK120.43205125
123CHEK20.42049447
124WNK30.41986752
125BCR0.41356148
126JAK20.41083489
127MAPKAPK30.39425990
128CSNK1G20.38894740
129CCNB10.38000689
130MAP3K50.37859505
131PRKG20.37743641
132ABL10.37001456
133RPS6KA40.36934890
134MAP3K80.35135855
135TSSK60.35074836
136MARK30.33952266
137TAOK20.33510397
138MAPKAPK20.33161226
139PAK10.33069987
140ALK0.32066829
141GRK60.32026981

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.76902796
2Proteasome_Homo sapiens_hsa030502.64600735
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.63337922
4Ribosome_Homo sapiens_hsa030102.48989925
5Leishmaniasis_Homo sapiens_hsa051402.04475102
6Primary immunodeficiency_Homo sapiens_hsa053402.03687062
7Other glycan degradation_Homo sapiens_hsa005111.94587470
8Allograft rejection_Homo sapiens_hsa053301.92419966
9Protein export_Homo sapiens_hsa030601.89872847
10Graft-versus-host disease_Homo sapiens_hsa053321.88921813
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88544090
12RNA polymerase_Homo sapiens_hsa030201.86400802
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80546293
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.79282237
15Folate biosynthesis_Homo sapiens_hsa007901.74064985
16Lysosome_Homo sapiens_hsa041421.72595682
17Pertussis_Homo sapiens_hsa051331.70989394
18Steroid biosynthesis_Homo sapiens_hsa001001.65166968
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.64725167
20Hematopoietic cell lineage_Homo sapiens_hsa046401.61381419
21One carbon pool by folate_Homo sapiens_hsa006701.60201575
22DNA replication_Homo sapiens_hsa030301.59621811
23Type I diabetes mellitus_Homo sapiens_hsa049401.58292760
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52211809
25Malaria_Homo sapiens_hsa051441.49059373
26Rheumatoid arthritis_Homo sapiens_hsa053231.47820133
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46543246
28Asthma_Homo sapiens_hsa053101.46542135
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.45370372
30Fatty acid elongation_Homo sapiens_hsa000621.43229441
31Legionellosis_Homo sapiens_hsa051341.40213717
32Osteoclast differentiation_Homo sapiens_hsa043801.39422637
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38051757
34Antigen processing and presentation_Homo sapiens_hsa046121.37056979
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36485556
36Oxidative phosphorylation_Homo sapiens_hsa001901.36032274
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33765120
38Pyrimidine metabolism_Homo sapiens_hsa002401.32493584
39RNA degradation_Homo sapiens_hsa030181.32354184
40Measles_Homo sapiens_hsa051621.32010964
41Phagosome_Homo sapiens_hsa041451.24560851
42B cell receptor signaling pathway_Homo sapiens_hsa046621.23862909
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22343215
44Ether lipid metabolism_Homo sapiens_hsa005651.14785520
45Shigellosis_Homo sapiens_hsa051311.14238079
46RNA transport_Homo sapiens_hsa030131.14032630
47Tuberculosis_Homo sapiens_hsa051521.13309846
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12891376
49Fanconi anemia pathway_Homo sapiens_hsa034601.08926455
50Homologous recombination_Homo sapiens_hsa034401.08913462
51Complement and coagulation cascades_Homo sapiens_hsa046101.08421170
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08073187
53Salmonella infection_Homo sapiens_hsa051321.06277796
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05822254
55Systemic lupus erythematosus_Homo sapiens_hsa053221.01622266
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00418733
57Parkinsons disease_Homo sapiens_hsa050120.98979183
58Base excision repair_Homo sapiens_hsa034100.96967012
59Collecting duct acid secretion_Homo sapiens_hsa049660.96788258
60Mismatch repair_Homo sapiens_hsa034300.94721027
61Viral myocarditis_Homo sapiens_hsa054160.93693040
62Autoimmune thyroid disease_Homo sapiens_hsa053200.93592921
63Herpes simplex infection_Homo sapiens_hsa051680.92658284
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92136130
65Vitamin B6 metabolism_Homo sapiens_hsa007500.91572141
66Sulfur relay system_Homo sapiens_hsa041220.91408190
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91248512
68Histidine metabolism_Homo sapiens_hsa003400.88251870
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86424753
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.84766562
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84270452
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83616603
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83216042
74Non-homologous end-joining_Homo sapiens_hsa034500.83014888
75Propanoate metabolism_Homo sapiens_hsa006400.82734296
76Arachidonic acid metabolism_Homo sapiens_hsa005900.82575880
77Cardiac muscle contraction_Homo sapiens_hsa042600.79703452
78Sphingolipid metabolism_Homo sapiens_hsa006000.79367202
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79251484
80Sulfur metabolism_Homo sapiens_hsa009200.78055187
81Peroxisome_Homo sapiens_hsa041460.76465377
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76242606
83African trypanosomiasis_Homo sapiens_hsa051430.73495539
84Basal transcription factors_Homo sapiens_hsa030220.73279609
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72697170
86Regulation of autophagy_Homo sapiens_hsa041400.72677673
87Pyruvate metabolism_Homo sapiens_hsa006200.71460531
88Influenza A_Homo sapiens_hsa051640.70642558
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70638489
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.70375091
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70083360
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69485576
93T cell receptor signaling pathway_Homo sapiens_hsa046600.69095705
94Apoptosis_Homo sapiens_hsa042100.68025644
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66203203
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.65196280
97Spliceosome_Homo sapiens_hsa030400.65146810
98Epstein-Barr virus infection_Homo sapiens_hsa051690.65092326
99Glutathione metabolism_Homo sapiens_hsa004800.63362724
100Metabolic pathways_Homo sapiens_hsa011000.62807107
101Caffeine metabolism_Homo sapiens_hsa002320.62403314
102Chemokine signaling pathway_Homo sapiens_hsa040620.62223052
103Alzheimers disease_Homo sapiens_hsa050100.62024677
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60307422
105Cell cycle_Homo sapiens_hsa041100.59928180
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58972089
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.58535844
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58364396
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57973727
110Purine metabolism_Homo sapiens_hsa002300.57731015
111Nucleotide excision repair_Homo sapiens_hsa034200.57600302
112Toxoplasmosis_Homo sapiens_hsa051450.56483523
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55742127
114Chemical carcinogenesis_Homo sapiens_hsa052040.55074683
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.55048780
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55014360
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54861146
118Pentose phosphate pathway_Homo sapiens_hsa000300.54000114
119Huntingtons disease_Homo sapiens_hsa050160.50558454
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49341858
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47497223
122p53 signaling pathway_Homo sapiens_hsa041150.44395839
123Carbon metabolism_Homo sapiens_hsa012000.41450536
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37266954
125Fatty acid degradation_Homo sapiens_hsa000710.36248753
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31432740
127Selenocompound metabolism_Homo sapiens_hsa004500.30916383
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27635011
129Mineral absorption_Homo sapiens_hsa049780.24906654
130Galactose metabolism_Homo sapiens_hsa000520.24052226
131Vitamin digestion and absorption_Homo sapiens_hsa049770.23724149

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