SFRP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bone trabecula formation (GO:0060346)7.31735597
2protein heterotrimerization (GO:0070208)6.57079577
3regulation of gene silencing by RNA (GO:0060966)5.98983881
4regulation of posttranscriptional gene silencing (GO:0060147)5.98983881
5regulation of gene silencing by miRNA (GO:0060964)5.98983881
6* collagen fibril organization (GO:0030199)5.61015864
7L-serine metabolic process (GO:0006563)5.44006777
8metanephric mesenchyme development (GO:0072075)5.23978996
9G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071995.12747860
10chondrocyte proliferation (GO:0035988)5.03875333
11axon extension involved in axon guidance (GO:0048846)5.01013642
12neuron projection extension involved in neuron projection guidance (GO:1902284)5.01013642
13kidney mesenchyme development (GO:0072074)4.94958105
14sequestering of extracellular ligand from receptor (GO:0035581)4.83865218
15glomerular filtration (GO:0003094)4.83305772
16pre-miRNA processing (GO:0031054)4.66454051
17embryonic cranial skeleton morphogenesis (GO:0048701)4.64429714
18middle ear morphogenesis (GO:0042474)4.56727402
19head development (GO:0060322)4.55971025
20heterochromatin organization (GO:0070828)4.48038034
21craniofacial suture morphogenesis (GO:0097094)4.44501337
22* planar cell polarity pathway involved in neural tube closure (GO:0090179)4.42092434
23renal filtration (GO:0097205)4.39912589
24* regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.36816442
25glomerular basement membrane development (GO:0032836)4.29790694
26outer ear morphogenesis (GO:0042473)4.28290297
27chromatin remodeling at centromere (GO:0031055)4.20684560
28* regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.19258150
29negative regulation of chondrocyte differentiation (GO:0032331)4.17009546
30prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.13176660
31regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.09498762
32* convergent extension (GO:0060026)4.07606160
33camera-type eye morphogenesis (GO:0048593)4.05934915
34cell migration involved in heart development (GO:0060973)4.02094091
35cell proliferation involved in metanephros development (GO:0072203)4.01644395
36* regulation of cell fate specification (GO:0042659)3.98259755
37collagen metabolic process (GO:0032963)3.94794893
38collagen catabolic process (GO:0030574)3.94135038
39positive regulation of mesenchymal cell proliferation (GO:0002053)3.88837216
40keratan sulfate catabolic process (GO:0042340)3.85700350
41notochord development (GO:0030903)3.82759972
42positive regulation of SMAD protein import into nucleus (GO:0060391)3.81918985
43CENP-A containing nucleosome assembly (GO:0034080)3.81848918
44establishment of integrated proviral latency (GO:0075713)3.79713528
45endodermal cell differentiation (GO:0035987)3.75782769
46multicellular organismal macromolecule metabolic process (GO:0044259)3.73917041
47dermatan sulfate biosynthetic process (GO:0030208)3.72725458
48negative regulation of catenin import into nucleus (GO:0035414)3.72568912
49regulation of mesenchymal cell proliferation (GO:0010464)3.71862430
50extracellular negative regulation of signal transduction (GO:1900116)3.70644690
51extracellular regulation of signal transduction (GO:1900115)3.70644690
52lung-associated mesenchyme development (GO:0060484)3.69945497
53hippo signaling (GO:0035329)3.65264721
54mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.64896964
55multicellular organismal catabolic process (GO:0044243)3.63823300
56mesenchymal cell proliferation (GO:0010463)3.62292270
57endothelial cell morphogenesis (GO:0001886)3.62256485
58* regulation of non-canonical Wnt signaling pathway (GO:2000050)3.61457345
59* chondrocyte development (GO:0002063)3.60588276
60cellular response to vitamin D (GO:0071305)3.59653536
61regulation of heart morphogenesis (GO:2000826)3.58700743
62insulin-like growth factor receptor signaling pathway (GO:0048009)3.57338446
63mesenchymal-epithelial cell signaling (GO:0060638)3.53963820
64cell proliferation involved in kidney development (GO:0072111)3.51780919
65multicellular organismal metabolic process (GO:0044236)3.51650184
66embryonic skeletal joint morphogenesis (GO:0060272)3.51481366
67cranial suture morphogenesis (GO:0060363)3.51315236
68presynaptic membrane assembly (GO:0097105)3.51208433
69paraxial mesoderm development (GO:0048339)3.48940240
70negative regulation of cartilage development (GO:0061037)3.45501408
71smooth muscle tissue development (GO:0048745)3.44742150
72negative regulation of fatty acid transport (GO:2000192)3.44352373
73positive regulation of smoothened signaling pathway (GO:0045880)3.44107194
74extracellular matrix assembly (GO:0085029)3.44059899
75skin morphogenesis (GO:0043589)3.43589139
76ribosomal small subunit assembly (GO:0000028)3.42677812
77negative regulation of axon extension involved in axon guidance (GO:0048843)3.38222141
78dermatan sulfate metabolic process (GO:0030205)3.36577600
79* Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.35979345
80histone exchange (GO:0043486)3.35392398
81regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.33667758
82DNA replication-independent nucleosome assembly (GO:0006336)3.32339550
83DNA replication-independent nucleosome organization (GO:0034724)3.32339550
84glomerular visceral epithelial cell development (GO:0072015)3.31245545
85branching involved in prostate gland morphogenesis (GO:0060442)3.29647148
86cellular response to vitamin (GO:0071295)3.29492812
87* regulation of establishment of planar polarity (GO:0090175)3.27309681
88eye morphogenesis (GO:0048592)3.23971146
89presynaptic membrane organization (GO:0097090)3.23204829
90cochlea morphogenesis (GO:0090103)3.21701472
91extracellular fibril organization (GO:0043206)3.20685565
92embryonic hindlimb morphogenesis (GO:0035116)3.20612070
93serine family amino acid biosynthetic process (GO:0009070)3.20074931
94regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.17586685
95extracellular matrix disassembly (GO:0022617)3.17498577
96branching involved in salivary gland morphogenesis (GO:0060445)3.17199401
97mesenchymal cell differentiation involved in renal system development (GO:2001012)3.13780792
98mesenchymal cell differentiation involved in kidney development (GO:0072161)3.13780792
99regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.13556080
100negative regulation of axon guidance (GO:1902668)3.13510036
101viral transcription (GO:0019083)3.13043777
102protein localization to kinetochore (GO:0034501)3.11036497
103cartilage morphogenesis (GO:0060536)3.08698730
104cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.08484116
105neural crest cell development (GO:0014032)3.07562862
106translational termination (GO:0006415)3.06079358
107protein complex localization (GO:0031503)3.04605761
108body morphogenesis (GO:0010171)3.03386818
109peptidyl-proline hydroxylation (GO:0019511)3.02766858
110palate development (GO:0060021)3.02590575
111positive regulation of epithelial to mesenchymal transition (GO:0010718)3.01782177
112hindlimb morphogenesis (GO:0035137)3.01552012
113establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.00968311
114dorsal/ventral axis specification (GO:0009950)3.00174116
115IMP biosynthetic process (GO:0006188)2.98997033
116hypothalamus development (GO:0021854)2.97949077
117regulation of helicase activity (GO:0051095)2.97367120
118regulation of axon extension involved in axon guidance (GO:0048841)2.95997859
119lateral sprouting from an epithelium (GO:0060601)2.95934031
120anatomical structure regression (GO:0060033)2.95498315
121* negative regulation of embryonic development (GO:0045992)2.95369888
122glomerular epithelial cell development (GO:0072310)2.94859299
123neuronal stem cell maintenance (GO:0097150)2.94750103
124negative chemotaxis (GO:0050919)2.94581909
125kinetochore organization (GO:0051383)2.93360029
126response to BMP (GO:0071772)2.92795991
127cellular response to BMP stimulus (GO:0071773)2.92795991
128positive regulation of gastrulation (GO:2000543)2.92201228
129mesenchymal cell development (GO:0014031)2.92104851
130substrate-dependent cell migration (GO:0006929)2.89869052
131* non-canonical Wnt signaling pathway (GO:0035567)2.88830049
132ATP-dependent chromatin remodeling (GO:0043044)2.87616603
133blood vessel maturation (GO:0001955)2.86038026
134limb development (GO:0060173)2.85410816
135appendage development (GO:0048736)2.85410816
136kinetochore assembly (GO:0051382)2.85375444
137negative regulation of gene silencing (GO:0060969)2.84656775
138somatic stem cell division (GO:0048103)2.83734453
139chaperone-mediated protein transport (GO:0072321)2.83282014
140anterior/posterior axis specification, embryo (GO:0008595)2.83208635
141regulation of gene silencing (GO:0060968)2.82789336
142* regulation of cell fate commitment (GO:0010453)2.81654735
143ribosomal small subunit biogenesis (GO:0042274)2.80509381
144negative regulation of translation, ncRNA-mediated (GO:0040033)2.79698182
145regulation of translation, ncRNA-mediated (GO:0045974)2.79698182
146negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79698182
147mitotic metaphase plate congression (GO:0007080)2.79679283
148DNA unwinding involved in DNA replication (GO:0006268)2.79019716
149regulation of SMAD protein import into nucleus (GO:0060390)2.78502931
150inner ear receptor cell development (GO:0060119)2.77255019
151cell fate commitment involved in formation of primary germ layer (GO:0060795)2.76724686
152regulation of stem cell maintenance (GO:2000036)2.75020683
153DNA damage response, detection of DNA damage (GO:0042769)2.74790655
154DNA replication checkpoint (GO:0000076)2.74470943
155IMP metabolic process (GO:0046040)2.72287601
156negative regulation of fibroblast apoptotic process (GO:2000270)2.71110061
157establishment of viral latency (GO:0019043)2.70689802
158ribosomal large subunit biogenesis (GO:0042273)2.67335411
159mesenchymal to epithelial transition (GO:0060231)2.66683355
160DNA strand elongation involved in DNA replication (GO:0006271)2.61181819
161cell proliferation in forebrain (GO:0021846)2.60906971
162negative regulation of androgen receptor signaling pathway (GO:0060766)2.60821520
163regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.58550223
164cotranslational protein targeting to membrane (GO:0006613)2.55268918
165negative regulation of telomerase activity (GO:0051974)2.55211845
166nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.55015095
167SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.54960482
168regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54865922
169regulation of mitotic spindle checkpoint (GO:1903504)2.54865922
170radial glial cell differentiation (GO:0060019)2.54611160
171cellular protein complex localization (GO:0034629)2.54217191
172protein localization to chromosome, centromeric region (GO:0071459)2.54049754
173pituitary gland development (GO:0021983)2.50095676
174negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.49872295
175negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.49872295
176negative regulation of mitotic sister chromatid segregation (GO:0033048)2.49872295
177negative regulation of mitotic sister chromatid separation (GO:2000816)2.49872295
178negative regulation of sister chromatid segregation (GO:0033046)2.49872295
179tongue development (GO:0043586)2.48630650
180protein targeting to ER (GO:0045047)2.48397317
181single strand break repair (GO:0000012)2.48376729
182negative regulation of chromosome segregation (GO:0051985)2.46224172
183DNA strand elongation (GO:0022616)2.45704987

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.34164503
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.65791790
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.39522111
4WT1_19549856_ChIP-ChIP_CCG9911_Human3.86960237
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.56516488
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.40156425
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.40156425
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.19636980
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.16799385
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.91617418
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.86508500
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.78896155
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75828813
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73627735
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.72792894
16CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.69901814
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66744802
18* SOX2_16153702_ChIP-ChIP_HESCs_Human2.57899418
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.56101097
20SOX2_18555785_ChIP-Seq_MESCs_Mouse2.50426506
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50356429
22TCF3_18692474_ChIP-Seq_MEFs_Mouse2.47950970
23* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46729057
24* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46729057
25* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.43356681
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.42623656
27* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.36101564
28RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33993803
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.32353357
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.29152107
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25317440
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.25313272
33* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24856994
34NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.23285906
35TP53_20018659_ChIP-ChIP_R1E_Mouse2.09927442
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06479535
37* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05580840
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97909417
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97875739
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.97468013
41TCF3_18692474_ChIP-Seq_MESCs_Mouse1.96486936
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94989214
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92578586
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.91447052
45SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.90607926
46* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88497104
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88351750
48CJUN_26792858_Chip-Seq_BT549_Human1.86600223
49BRD4_25478319_ChIP-Seq_HGPS_Human1.84974576
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.83001975
51AR_21909140_ChIP-Seq_LNCAP_Human1.81742192
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81665292
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76510643
54SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.74542566
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.74143163
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73895529
57TP53_18474530_ChIP-ChIP_U2OS_Human1.71715306
58* RNF2_27304074_Chip-Seq_ESCs_Mouse1.67709174
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66592702
60ISL1_27105846_Chip-Seq_CPCs_Mouse1.66514590
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65711858
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65563519
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.64498042
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63949268
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61368035
66* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61142913
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60039307
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58464272
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58204270
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.58173055
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.57521186
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56019588
73CLOCK_20551151_ChIP-Seq_293T_Human1.54448879
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54198251
75POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.52718174
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51721506
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51197738
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49954531
79SOX2_18692474_ChIP-Seq_MEFs_Mouse1.48701994
80AR_21572438_ChIP-Seq_LNCaP_Human1.47008965
81NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.46977130
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.46907809
83* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46458534
84FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.46251466
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.43880949
86* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39942515
87* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39942515
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.39792782
89EZH2_22144423_ChIP-Seq_EOC_Human1.38934269
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37748784
91TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.36533327
92NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35720362
93NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35518204
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35108309
95* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34344707
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.34177471
97* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33643263
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30637029
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27955347
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.26464571
101* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25954544
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.24811497
103NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24058627
104TTF2_22483619_ChIP-Seq_HELA_Human1.23520597
105XRN2_22483619_ChIP-Seq_HELA_Human1.23196313
106SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22650311
107SA1_22415368_ChIP-Seq_MEFs_Mouse1.22439282
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18762481
109EWS_26573619_Chip-Seq_HEK293_Human1.18156120
110* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18029031
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17992418
112NANOG_21062744_ChIP-ChIP_HESCs_Human1.17029666
113TP53_16413492_ChIP-PET_HCT116_Human1.16182922
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15967687
115NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15696512
116SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15509254
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.15498130
118MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15400537
119ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15101830
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14916827
121MYC_18940864_ChIP-ChIP_HL60_Human1.14719469
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14050581
123FUS_26573619_Chip-Seq_HEK293_Human1.13676051
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13526251
125THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13212816
126WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11854510
127* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09343935
128EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08983244
129* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08188555
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08158051
131TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07994133
132EST1_17652178_ChIP-ChIP_JURKAT_Human1.07723160
133GBX2_23144817_ChIP-Seq_PC3_Human1.07480885
134TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07239204
135TCF4_18268006_ChIP-ChIP_LS174T_Human1.07042720
136SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06360094
137* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05605264
138ESR1_21235772_ChIP-Seq_MCF-7_Human1.04182775
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03236957
140SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03074872
141POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02741159
142ARNT_22903824_ChIP-Seq_MCF-7_Human1.02606613
143NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01959291
144* NANOG_16518401_ChIP-PET_MESCs_Mouse1.01877435
145* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01371313
146HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00297521
147ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00259129
148NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00154358
149* EZH2_27294783_Chip-Seq_ESCs_Mouse0.99292495
150IRF1_19129219_ChIP-ChIP_H3396_Human0.98166790
151BCAT_22108803_ChIP-Seq_LS180_Human0.97024303
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96975236
153SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96598628
154RXR_22108803_ChIP-Seq_LS180_Human0.95657590
155BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95568129
156GABP_17652178_ChIP-ChIP_JURKAT_Human0.95552945
157BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95199062
158STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95044300
159* NANOG_16153702_ChIP-ChIP_HESCs_Human0.94547898
160CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94387917
161ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94091925
162CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93996379
163SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93257104
164ELK1_19687146_ChIP-ChIP_HELA_Human0.92397553
165ERG_21242973_ChIP-ChIP_JURKAT_Human0.92223306
166AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91820212
167P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91740275
168TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91729545
169AHR_22903824_ChIP-Seq_MCF-7_Human0.88784270
170KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87614445

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology7.17309962
2MP0008438_abnormal_cutaneous_collagen6.54633016
3MP0005275_abnormal_skin_tensile4.64616132
4MP0006292_abnormal_olfactory_placode3.61788240
5MP0003136_yellow_coat_color3.59651640
6MP0002254_reproductive_system_inflammat2.87886320
7MP0010030_abnormal_orbit_morphology2.87148813
8MP0003705_abnormal_hypodermis_morpholog2.85905440
9MP0003122_maternal_imprinting2.81144243
10MP0009384_cardiac_valve_regurgitation2.70122307
11MP0003385_abnormal_body_wall2.66391417
12MP0009250_abnormal_appendicular_skeleto2.58829761
13MP0003279_aneurysm2.51865861
14MP0005508_abnormal_skeleton_morphology2.50695759
15MP0005377_hearing/vestibular/ear_phenot2.34175501
16MP0003878_abnormal_ear_physiology2.34175501
17MP0009379_abnormal_foot_pigmentation2.28311357
18MP0006054_spinal_hemorrhage2.22398265
19MP0009053_abnormal_anal_canal2.20880062
20MP0002108_abnormal_muscle_morphology2.20356895
21MP0005257_abnormal_intraocular_pressure2.17629355
22MP0003693_abnormal_embryo_hatching2.17547673
23MP0000049_abnormal_middle_ear2.16604841
24MP0004272_abnormal_basement_membrane2.16416414
25MP0001958_emphysema2.15716349
26MP0003942_abnormal_urinary_system2.05520171
27MP0000534_abnormal_ureter_morphology1.95357479
28MP0009672_abnormal_birth_weight1.91448693
29MP0004957_abnormal_blastocyst_morpholog1.84497524
30MP0002249_abnormal_larynx_morphology1.83859568
31MP0003755_abnormal_palate_morphology1.80038254
32MP0000537_abnormal_urethra_morphology1.79609228
33MP0003890_abnormal_embryonic-extraembry1.77469685
34MP0003123_paternal_imprinting1.71959246
35MP0002896_abnormal_bone_mineralization1.69962000
36MP0005623_abnormal_meninges_morphology1.69752600
37MP0000762_abnormal_tongue_morphology1.69201242
38MP0002932_abnormal_joint_morphology1.65930893
39MP0002653_abnormal_ependyma_morphology1.62823448
40MP0000428_abnormal_craniofacial_morphol1.58404989
41MP0003935_abnormal_craniofacial_develop1.58229691
42MP0002233_abnormal_nose_morphology1.53746764
43MP0008932_abnormal_embryonic_tissue1.52245549
44* MP0003937_abnormal_limbs/digits/tail_de1.51597994
45MP0002115_abnormal_skeleton_extremities1.51013558
46MP0003121_genomic_imprinting1.49047829
47MP0000163_abnormal_cartilage_morphology1.48876286
48MP0003111_abnormal_nucleus_morphology1.46559332
49MP0002282_abnormal_trachea_morphology1.43934344
50MP0008789_abnormal_olfactory_epithelium1.43772077
51MP0002060_abnormal_skin_morphology1.43120781
52MP0000778_abnormal_nervous_system1.41565670
53MP0003115_abnormal_respiratory_system1.40294280
54MP0002116_abnormal_craniofacial_bone1.39861359
55MP0001188_hyperpigmentation1.38830555
56MP0001542_abnormal_bone_strength1.38517870
57* MP0002109_abnormal_limb_morphology1.38490734
58MP0008877_abnormal_DNA_methylation1.38319288
59MP0001299_abnormal_eye_distance/1.38113665
60MP0000733_abnormal_muscle_development1.37450640
61MP0002938_white_spotting1.36994841
62MP0004134_abnormal_chest_morphology1.34577778
63MP0010368_abnormal_lymphatic_system1.33922350
64MP0002295_abnormal_pulmonary_circulatio1.33760450
65MP0000516_abnormal_urinary_system1.31071251
66MP0005367_renal/urinary_system_phenotyp1.31071251
67MP0000432_abnormal_head_morphology1.26621208
68* MP0003861_abnormal_nervous_system1.26536257
69* MP0002113_abnormal_skeleton_development1.26491253
70MP0002084_abnormal_developmental_patter1.25564966
71MP0005390_skeleton_phenotype1.23007557
72MP0005499_abnormal_olfactory_system1.21280671
73MP0005394_taste/olfaction_phenotype1.21280671
74MP0001270_distended_abdomen1.20999640
75MP0000579_abnormal_nail_morphology1.19081250
76MP0000566_synostosis1.18427137
77MP0005391_vision/eye_phenotype1.16105479
78MP0001293_anophthalmia1.15520217
79MP0010094_abnormal_chromosome_stability1.13787841
80MP0008058_abnormal_DNA_repair1.08941009
81MP0003077_abnormal_cell_cycle1.07131960
82MP0000767_abnormal_smooth_muscle1.06842226
83MP0003283_abnormal_digestive_organ1.06219799
84MP0003566_abnormal_cell_adhesion1.05413574
85MP0001879_abnormal_lymphatic_vessel1.01987913
86MP0005076_abnormal_cell_differentiation1.01785456
87MP0005023_abnormal_wound_healing1.01045392
88MP0003941_abnormal_skin_development0.99484217
89MP0001346_abnormal_lacrimal_gland0.99477949
90MP0000613_abnormal_salivary_gland0.99317772
91MP0001730_embryonic_growth_arrest0.99187854
92* MP0002111_abnormal_tail_morphology0.98022150
93MP0003787_abnormal_imprinting0.97848395
94MP0006072_abnormal_retinal_apoptosis0.96439453
95MP0001502_abnormal_circadian_rhythm0.95548257
96MP0001485_abnormal_pinna_reflex0.95149317
97MP0000631_abnormal_neuroendocrine_gland0.94855648
98MP0009703_decreased_birth_body0.94322752
99* MP0002114_abnormal_axial_skeleton0.94264068
100MP0005380_embryogenesis_phenotype0.93913911
101MP0001672_abnormal_embryogenesis/_devel0.93913911
102MP0002177_abnormal_outer_ear0.93113239
103MP0002998_abnormal_bone_remodeling0.90106975
104MP0003938_abnormal_ear_development0.89509350
105MP0001340_abnormal_eyelid_morphology0.89351028
106MP0001243_abnormal_dermal_layer0.87817172
107MP0001697_abnormal_embryo_size0.87369093
108MP0002697_abnormal_eye_size0.87018577
109MP0001529_abnormal_vocalization0.84632312
110MP0003119_abnormal_digestive_system0.84566694
111MP0002933_joint_inflammation0.83720893
112MP0002092_abnormal_eye_morphology0.82543147
113MP0004197_abnormal_fetal_growth/weight/0.82071956
114MP0000026_abnormal_inner_ear0.82031249
115MP0005171_absent_coat_pigmentation0.81952502
116MP0000462_abnormal_digestive_system0.81618050
117MP0005248_abnormal_Harderian_gland0.81281058
118MP0003795_abnormal_bone_structure0.80631501
119MP0002081_perinatal_lethality0.79291621
120MP0002925_abnormal_cardiovascular_devel0.78323437
121MP0001175_abnormal_lung_morphology0.76337271
122MP0003091_abnormal_cell_migration0.75729389
123MP0003984_embryonic_growth_retardation0.75307530
124MP0001286_abnormal_eye_development0.75148483
125MP0000350_abnormal_cell_proliferation0.75146863
126MP0002088_abnormal_embryonic_growth/wei0.73701908
127MP0010352_gastrointestinal_tract_polyps0.72587890
128MP0004885_abnormal_endolymph0.72335793
129MP0003567_abnormal_fetal_cardiomyocyte0.71842950
130MP0000013_abnormal_adipose_tissue0.71587383
131MP0002152_abnormal_brain_morphology0.71374831
132MP0001614_abnormal_blood_vessel0.70565142
133MP0002128_abnormal_blood_circulation0.70379869
134MP0005193_abnormal_anterior_eye0.67871814
135MP0005197_abnormal_uvea_morphology0.67549788
136MP0005195_abnormal_posterior_eye0.66267828
137MP0002796_impaired_skin_barrier0.64838010
138MP0001984_abnormal_olfaction0.64213951
139MP0001849_ear_inflammation0.63674209
140MP0001177_atelectasis0.63638310
141MP0002168_other_aberrant_phenotype0.61729966
142MP0002085_abnormal_embryonic_tissue0.61564523
143MP0000003_abnormal_adipose_tissue0.61202011
144MP0000266_abnormal_heart_morphology0.58678654
145MP0004133_heterotaxia0.57490381
146MP0002089_abnormal_postnatal_growth/wei0.57151059

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.72983880
2Premature rupture of membranes (HP:0001788)6.08699035
3Shallow orbits (HP:0000586)5.07042043
4Septo-optic dysplasia (HP:0100842)5.06116304
5Short 4th metacarpal (HP:0010044)4.50877910
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.50877910
7Broad metatarsal (HP:0001783)4.37379060
8Ankle contracture (HP:0006466)4.32843876
9Aortic dissection (HP:0002647)4.22107963
10Soft skin (HP:0000977)4.06473990
11Anophthalmia (HP:0000528)3.84652233
12Bladder diverticulum (HP:0000015)3.78427940
13Abnormality of dentin (HP:0010299)3.57277312
14Abnormality of the 4th metacarpal (HP:0010012)3.50192593
15Neonatal short-limb short stature (HP:0008921)3.49640832
16Atrophic scars (HP:0001075)3.45995893
17Rib fusion (HP:0000902)3.44134447
18Microglossia (HP:0000171)3.42867389
19Follicular hyperkeratosis (HP:0007502)3.41066900
20Aortic aneurysm (HP:0004942)3.40487960
21Colon cancer (HP:0003003)3.36676754
22Peritonitis (HP:0002586)3.34249945
23Biconcave vertebral bodies (HP:0004586)3.30702588
24Vitreoretinal degeneration (HP:0000655)3.29120295
25Partial duplication of thumb phalanx (HP:0009944)3.23861275
26Reticulocytopenia (HP:0001896)3.17320840
27Abnormality of the labia minora (HP:0012880)3.16144553
28Genu recurvatum (HP:0002816)3.15554861
29Mitral valve prolapse (HP:0001634)3.13712725
30Absent septum pellucidum (HP:0001331)3.12618565
31Asymmetry of the thorax (HP:0001555)3.10257897
32Maternal diabetes (HP:0009800)3.09155203
33Dilatation of the ascending aorta (HP:0005111)3.07099533
34Wormian bones (HP:0002645)3.06473182
35Wide anterior fontanel (HP:0000260)3.06366557
36Fragile skin (HP:0001030)2.97473725
37Blue sclerae (HP:0000592)2.97186282
38Partial duplication of the phalanx of hand (HP:0009999)2.93333475
39Cervical subluxation (HP:0003308)2.87583328
40Bell-shaped thorax (HP:0001591)2.79880629
41Choanal stenosis (HP:0000452)2.79272915
42Vertebral compression fractures (HP:0002953)2.75095733
43Hemivertebrae (HP:0002937)2.72290996
44Cerebral aneurysm (HP:0004944)2.70900586
45Abnormality of the septum pellucidum (HP:0007375)2.70052290
46Type 1 muscle fiber predominance (HP:0003803)2.69305927
47Hyperextensible skin (HP:0000974)2.69115567
48Coronal craniosynostosis (HP:0004440)2.69003420
49Bowel diverticulosis (HP:0005222)2.66829988
50Deviation of the hallux (HP:0010051)2.60872199
51Broad thumb (HP:0011304)2.54464662
52Cutaneous syndactyly (HP:0012725)2.53564997
53Joint laxity (HP:0001388)2.52157823
54Duplication of thumb phalanx (HP:0009942)2.50059475
55Hallux valgus (HP:0001822)2.49469659
56Preaxial foot polydactyly (HP:0001841)2.48902109
57Buphthalmos (HP:0000557)2.43619500
58Broad ribs (HP:0000885)2.42996767
59Overgrowth (HP:0001548)2.42864891
60Morphological abnormality of the middle ear (HP:0008609)2.42050990
61Optic nerve hypoplasia (HP:0000609)2.42048789
62Renal duplication (HP:0000075)2.41497116
63Slender build (HP:0001533)2.40793820
64Bifid tongue (HP:0010297)2.39454145
65Breech presentation (HP:0001623)2.38630996
66Missing ribs (HP:0000921)2.38607121
67Bilateral microphthalmos (HP:0007633)2.38145544
68Spinal cord lesions (HP:0100561)2.37524012
69Syringomyelia (HP:0003396)2.37524012
70Esophageal atresia (HP:0002032)2.33987922
71High anterior hairline (HP:0009890)2.33234672
72Lymphangioma (HP:0100764)2.32181921
73Vascular tortuosity (HP:0004948)2.31867178
74Ectopia lentis (HP:0001083)2.31741858
75Wide cranial sutures (HP:0010537)2.31269279
76Stenosis of the external auditory canal (HP:0000402)2.31161400
77Diastasis recti (HP:0001540)2.29437709
78Metaphyseal cupping (HP:0003021)2.29407817
79Wrist flexion contracture (HP:0001239)2.28248511
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28174060
81Cortical dysplasia (HP:0002539)2.26737490
82Hepatoblastoma (HP:0002884)2.25790653
83Broad long bones (HP:0005622)2.23491545
84Abnormality of the parietal bone (HP:0002696)2.22928233
85Infantile muscular hypotonia (HP:0008947)2.22296095
86Abnormal number of incisors (HP:0011064)2.21487001
87Protruding ear (HP:0000411)2.21283076
88Mesomelia (HP:0003027)2.20399623
89Decreased skull ossification (HP:0004331)2.19645137
90Broad phalanges of the hand (HP:0009768)2.19630037
91Mild short stature (HP:0003502)2.19344372
92Broad finger (HP:0001500)2.17193248
93Vertebral clefting (HP:0008428)2.17057541
94Spinal rigidity (HP:0003306)2.16148353
95Hyperglycinemia (HP:0002154)2.16137120
96Elbow flexion contracture (HP:0002987)2.15611063
97Abnormal lung lobation (HP:0002101)2.14794791
98Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.13254669
99Abnormal delivery (HP:0001787)2.12913338
100Spastic diplegia (HP:0001264)2.11993653
101Trigonocephaly (HP:0000243)2.11934873
102Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11932073
103Short hallux (HP:0010109)2.11629301
104Aplasia involving bones of the extremities (HP:0009825)2.11021295
105Aplasia involving bones of the upper limbs (HP:0009823)2.11021295
106Aplasia of the phalanges of the hand (HP:0009802)2.11021295
107Limited hip movement (HP:0008800)2.07694835
108Short middle phalanx of finger (HP:0005819)2.07419634
109Sclerocornea (HP:0000647)2.07317529
110Narrow nasal bridge (HP:0000446)2.07207871
111Macrocytic anemia (HP:0001972)2.06025451
112Ectopic kidney (HP:0000086)2.05877174
113Disproportionate tall stature (HP:0001519)2.05375398
114Arterial tortuosity (HP:0005116)2.05261073
115Irregular epiphyses (HP:0010582)2.03728947
116Turricephaly (HP:0000262)2.03255229
117Aplasia/Hypoplasia of the breasts (HP:0010311)2.03102560
118Broad toe (HP:0001837)2.01979605
119Mitral regurgitation (HP:0001653)2.01923426
120Delayed cranial suture closure (HP:0000270)2.00987386
121Flat cornea (HP:0007720)2.00126290
122Aplasia/Hypoplasia of the hallux (HP:0008362)1.99836299
123Breast aplasia (HP:0100783)1.99319347
124Osteoarthritis (HP:0002758)1.98886293
125Spondylolisthesis (HP:0003302)1.98461876
126Hypoplasia of the maxilla (HP:0000327)1.97560541
127Osteopenia (HP:0000938)1.97508058
128Abnormality of the middle phalanges of the toes (HP:0010183)1.96870219
129Short middle phalanx of the 5th finger (HP:0004220)1.96739889
130Abnormality of the phalanges of the 2nd finger (HP:0009541)1.96514387
131Femoral bowing (HP:0002980)1.96388789
132Abnormality of the peritoneum (HP:0002585)1.95495989
133Tibial bowing (HP:0002982)1.95480063
134Abnormality of the acetabulum (HP:0003170)1.95040654
135Selective tooth agenesis (HP:0001592)1.94219296
136Camptodactyly of toe (HP:0001836)1.94037698
137Knee flexion contracture (HP:0006380)1.93479368
138Skull defect (HP:0001362)1.92375224
139Hip contracture (HP:0003273)1.92257190
140Synostosis of carpal bones (HP:0005048)1.91619725
141Dislocated radial head (HP:0003083)1.91266767
142Hypoplastic ischia (HP:0003175)1.90637750
143Abnormality of skull ossification (HP:0002703)1.90283900
144Overriding aorta (HP:0002623)1.89892371
145Abnormality of the radial head (HP:0003995)1.89346958
146Bronchomalacia (HP:0002780)1.87527577
147Atresia of the external auditory canal (HP:0000413)1.87113695
148Inguinal hernia (HP:0000023)1.87108586
149Abnormality of the phalanges of the hallux (HP:0010057)1.87016320
150Abnormality of the diencephalon (HP:0010662)1.86719362
151Abnormality of abdominal situs (HP:0011620)1.86667576
152Abdominal situs inversus (HP:0003363)1.86667576
153Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86485351
154Abnormality of the calcaneus (HP:0008364)1.85878521
155Ulnar bowing (HP:0003031)1.84769946
156Renal hypoplasia (HP:0000089)1.83762698
157Abnormality of cells of the erythroid lineage (HP:0012130)1.83003181
158Cutaneous finger syndactyly (HP:0010554)1.81967933
159Renovascular hypertension (HP:0100817)1.80857942
160Birth length less than 3rd percentile (HP:0003561)1.80190136
161Broad phalanx (HP:0006009)1.79888531
162Aneurysm (HP:0002617)1.79113263
163Nephroblastoma (Wilms tumor) (HP:0002667)1.78550321
164Pulmonary artery stenosis (HP:0004415)1.78197675
165Rectovaginal fistula (HP:0000143)1.77820665
166Rectal fistula (HP:0100590)1.77820665
167Omphalocele (HP:0001539)1.77596653
168Humeroradial synostosis (HP:0003041)1.77551424
169Synostosis involving the elbow (HP:0003938)1.77551424
170Patent foramen ovale (HP:0001655)1.76625440
171Aqueductal stenosis (HP:0002410)1.75273937
172Venous insufficiency (HP:0005293)1.74907198
173Hyperglycinuria (HP:0003108)1.74865822
174Hypoplastic pelvis (HP:0008839)1.74771579
175Mildly elevated creatine phosphokinase (HP:0008180)1.74663984
176Myelomeningocele (HP:0002475)1.74105178
177Triphalangeal thumb (HP:0001199)1.73979420
178Congenital glaucoma (HP:0001087)1.73036103
179Meckel diverticulum (HP:0002245)1.72947821
180Midline defect of the nose (HP:0004122)1.72284359
181Facial cleft (HP:0002006)1.72103138
182Depressed nasal tip (HP:0000437)1.71506012
183Hypoplastic female external genitalia (HP:0012815)1.71281306
184Abnormality of the phalanges of the 5th finger (HP:0004213)1.71112625
185Increased nuchal translucency (HP:0010880)1.70409641
186Gastrointestinal atresia (HP:0002589)1.69581265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA36.50885340
2DDR25.86774074
3LATS14.15531722
4SIK14.12508473
5EPHB23.78709211
6PDGFRA3.60173869
7LATS22.84181466
8TTK2.74075011
9MKNK22.68476587
10VRK22.37610365
11TAF12.36845882
12FGFR22.11009566
13DYRK22.09995215
14TNIK2.09645700
15TRIB32.00857606
16BUB11.96538791
17CDK191.93154162
18TYRO31.86783240
19PNCK1.85906764
20TTN1.85560374
21CASK1.80742915
22STK241.74151204
23STK31.72699673
24FRK1.68870133
25TGFBR21.68290723
26FGFR11.61503888
27WEE11.58995627
28SRPK11.58666564
29TSSK61.58548953
30STK161.58094629
31DMPK1.51296962
32PASK1.43219941
33DYRK31.40427035
34PAK21.38423586
35NLK1.29196400
36MYLK1.28459211
37BRSK21.26016101
38PLK11.26002619
39PIK3CA1.25902675
40TGFBR11.21623256
41NTRK21.21571261
42PLK41.20318058
43VRK11.20295917
44NEK91.19746794
45MAP3K101.19311946
46RIPK11.17292134
47RPS6KA41.16683013
48STK38L1.14975224
49FER1.14553768
50AKT31.14517098
51PDGFRB1.11539399
52PKN21.10985084
53ERBB31.09979896
54EPHA41.06513830
55MET1.05841811
56PLK21.05520140
57PTK21.04689230
58WNK11.04218154
59PAK41.04121467
60ROCK11.03881425
61WNK31.03275845
62MTOR1.03220121
63PTK61.02261180
64SMG10.99188779
65MAP3K40.98117802
66CAMK1D0.95904463
67NUAK10.95331285
68PAK30.94397002
69CDK120.90668774
70EIF2AK20.89768968
71CAMK1G0.89600665
72BMX0.88827458
73PBK0.87889953
74FGFR30.86755890
75PTK2B0.81445009
76MKNK10.78206037
77ICK0.77870362
78NME10.77832759
79PLK30.75542502
80AURKB0.73743465
81ADRBK10.73720968
82LRRK20.73448178
83FGFR40.72949169
84CDK60.72925146
85ATR0.71649725
86ERN10.71261941
87BCR0.69719644
88JAK10.68604914
89ROCK20.68296072
90NTRK10.68020535
91CSNK1G10.65728219
92CDK30.65294881
93CSNK1A1L0.64712626
94CSNK1G20.63909042
95ATM0.62976514
96STK40.61427683
97CHEK10.61391096
98ERBB20.61287296
99PRKCH0.60523153
100CDK80.59290394
101CSF1R0.58806201
102DYRK1A0.58405400
103NEK10.56568766
104BRAF0.54005888
105STK110.53283756
106PRKDC0.53197130
107MAP2K70.52491513
108ALK0.51363411
109SGK2230.51028034
110SGK4940.51028034
111ERBB40.50594275
112BRD40.50182934
113CDC42BPA0.49611912
114KSR10.49568629
115BRSK10.48691988
116CDK70.47152981
117CDK20.47071818
118KIT0.45722970
119UHMK10.45657920
120INSR0.45432906
121MAPK150.44764740
122GSK3A0.44039695
123CDC70.43896731
124SRC0.41898198
125CAMK10.41277057
126FLT30.41248639
127MAP3K90.41213017
128MAPK10.41007392
129ZAK0.40118530
130PRKCE0.39991719
131CSNK1G30.39095967
132DYRK1B0.38413569
133CHUK0.37261834
134EEF2K0.35610383
135NEK20.35411850
136PRKCG0.34442681
137ACVR1B0.34432096
138CSNK2A20.34225083
139CDK11A0.34124922
140CSNK1A10.33106245
141AURKA0.32322605
142PRKD10.30605353
143PRKD30.28983241
144IGF1R0.28781738
145PRKD20.27693770
146TIE10.27058112
147MAPK80.26545672
148ILK0.26031692
149AKT10.23930301
150MAPK90.22333884
151MELK0.21542381
152CAMK40.21022140
153MAPK70.20445945
154MAPK140.19834705
155TRPM70.19632970
156CHEK20.18757170
157MAP2K10.16366072
158CDK10.16199617
159CSNK1D0.14988800
160MAPK30.13579438
161GSK3B0.12793363
162CSNK1E0.12684980

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.18506092
2Ribosome_Homo sapiens_hsa030103.50308391
3Basal cell carcinoma_Homo sapiens_hsa052173.38287526
4Mismatch repair_Homo sapiens_hsa034303.35887598
5DNA replication_Homo sapiens_hsa030303.23099424
6Protein digestion and absorption_Homo sapiens_hsa049743.05217837
7Focal adhesion_Homo sapiens_hsa045102.87072774
8Hedgehog signaling pathway_Homo sapiens_hsa043402.73490020
9Spliceosome_Homo sapiens_hsa030402.45404304
10Hippo signaling pathway_Homo sapiens_hsa043902.38056557
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36800706
12Adherens junction_Homo sapiens_hsa045202.34049903
13Proteoglycans in cancer_Homo sapiens_hsa052052.29489176
14TGF-beta signaling pathway_Homo sapiens_hsa043502.22404173
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.02592295
16* Wnt signaling pathway_Homo sapiens_hsa043102.02083409
17Axon guidance_Homo sapiens_hsa043602.00705142
18MicroRNAs in cancer_Homo sapiens_hsa052061.98929018
19RNA polymerase_Homo sapiens_hsa030201.98738502
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97780595
21Renin-angiotensin system_Homo sapiens_hsa046141.94339204
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.92462125
23Base excision repair_Homo sapiens_hsa034101.91794332
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87513497
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86857736
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86006226
27Homologous recombination_Homo sapiens_hsa034401.84980105
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.80952893
29RNA transport_Homo sapiens_hsa030131.80074507
30PI3K-Akt signaling pathway_Homo sapiens_hsa041511.76201864
31Steroid biosynthesis_Homo sapiens_hsa001001.75813480
32One carbon pool by folate_Homo sapiens_hsa006701.71319034
33Amoebiasis_Homo sapiens_hsa051461.69942535
34Melanoma_Homo sapiens_hsa052181.69884468
35mRNA surveillance pathway_Homo sapiens_hsa030151.69251519
36Nucleotide excision repair_Homo sapiens_hsa034201.68507519
37Prostate cancer_Homo sapiens_hsa052151.67600338
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.66875711
39Dilated cardiomyopathy_Homo sapiens_hsa054141.66529657
40Fanconi anemia pathway_Homo sapiens_hsa034601.66005165
41Non-homologous end-joining_Homo sapiens_hsa034501.63286994
42Vitamin B6 metabolism_Homo sapiens_hsa007501.57452156
43Small cell lung cancer_Homo sapiens_hsa052221.56573689
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.55098482
45RNA degradation_Homo sapiens_hsa030181.54073824
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.52288805
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.51230433
48Melanogenesis_Homo sapiens_hsa049161.50448018
49Pathways in cancer_Homo sapiens_hsa052001.49581677
50Malaria_Homo sapiens_hsa051441.48741775
51Protein export_Homo sapiens_hsa030601.40168456
52Chronic myeloid leukemia_Homo sapiens_hsa052201.39098357
53Selenocompound metabolism_Homo sapiens_hsa004501.36816480
54Colorectal cancer_Homo sapiens_hsa052101.34986590
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34979515
56Bladder cancer_Homo sapiens_hsa052191.30958088
57Glioma_Homo sapiens_hsa052141.29674406
58Basal transcription factors_Homo sapiens_hsa030221.27715711
59Biosynthesis of amino acids_Homo sapiens_hsa012301.23847836
60Pancreatic cancer_Homo sapiens_hsa052121.18530520
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18147232
62HTLV-I infection_Homo sapiens_hsa051661.17524512
63Rap1 signaling pathway_Homo sapiens_hsa040151.14586936
64Cell cycle_Homo sapiens_hsa041101.13499339
65Proteasome_Homo sapiens_hsa030501.13065686
66Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12970399
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12056466
68Notch signaling pathway_Homo sapiens_hsa043301.09409559
69Endometrial cancer_Homo sapiens_hsa052131.06718713
70Lysine degradation_Homo sapiens_hsa003101.02060744
71Platelet activation_Homo sapiens_hsa046110.99464342
72Viral myocarditis_Homo sapiens_hsa054160.96508762
73p53 signaling pathway_Homo sapiens_hsa041150.95069490
74Renal cell carcinoma_Homo sapiens_hsa052110.93529837
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92943294
76mTOR signaling pathway_Homo sapiens_hsa041500.91879327
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91501745
78Gap junction_Homo sapiens_hsa045400.90799659
79Estrogen signaling pathway_Homo sapiens_hsa049150.89077564
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88316812
81Propanoate metabolism_Homo sapiens_hsa006400.88252239
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87531552
83Huntingtons disease_Homo sapiens_hsa050160.87198565
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86867322
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.86769400
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86557215
87Pyruvate metabolism_Homo sapiens_hsa006200.86540083
88Parkinsons disease_Homo sapiens_hsa050120.85943251
89Tight junction_Homo sapiens_hsa045300.83976606
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83593716
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83478972
92Purine metabolism_Homo sapiens_hsa002300.82715196
93Thyroid cancer_Homo sapiens_hsa052160.82670569
94Pyrimidine metabolism_Homo sapiens_hsa002400.81623106
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79494967
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78715227
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78344300
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.77705797
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77470646
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.77175622
101Oxidative phosphorylation_Homo sapiens_hsa001900.75980974
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73096182
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72684030
104Thyroid hormone synthesis_Homo sapiens_hsa049180.72387733
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71499355
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.71450165
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70242666
108Folate biosynthesis_Homo sapiens_hsa007900.68144023
109Hepatitis B_Homo sapiens_hsa051610.66407930
110Non-small cell lung cancer_Homo sapiens_hsa052230.66405975
111FoxO signaling pathway_Homo sapiens_hsa040680.66344665
112Cardiac muscle contraction_Homo sapiens_hsa042600.66223342
113Viral carcinogenesis_Homo sapiens_hsa052030.65713402
114Vitamin digestion and absorption_Homo sapiens_hsa049770.65388151
115Renin secretion_Homo sapiens_hsa049240.65294483
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64566428
117Ras signaling pathway_Homo sapiens_hsa040140.64039575
118Arginine and proline metabolism_Homo sapiens_hsa003300.60141665
119Ovarian steroidogenesis_Homo sapiens_hsa049130.59897771
120Glutathione metabolism_Homo sapiens_hsa004800.57286287
121Fatty acid elongation_Homo sapiens_hsa000620.57219146
122N-Glycan biosynthesis_Homo sapiens_hsa005100.56999127
123Insulin resistance_Homo sapiens_hsa049310.56486105
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55654442
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54604837
126TNF signaling pathway_Homo sapiens_hsa046680.54186050
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50134894
128Oocyte meiosis_Homo sapiens_hsa041140.48093751
129cAMP signaling pathway_Homo sapiens_hsa040240.47557325
130AMPK signaling pathway_Homo sapiens_hsa041520.46976159
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.46867873
132Carbon metabolism_Homo sapiens_hsa012000.46747857
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46741089
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45942083
135Type II diabetes mellitus_Homo sapiens_hsa049300.45643020
136MAPK signaling pathway_Homo sapiens_hsa040100.44590252
137Fatty acid metabolism_Homo sapiens_hsa012120.44486774
138Alzheimers disease_Homo sapiens_hsa050100.42338511
139Cocaine addiction_Homo sapiens_hsa050300.41914113
140Toxoplasmosis_Homo sapiens_hsa051450.41864421
141GnRH signaling pathway_Homo sapiens_hsa049120.40957221
142HIF-1 signaling pathway_Homo sapiens_hsa040660.40402321
143Alcoholism_Homo sapiens_hsa050340.40218369
144Choline metabolism in cancer_Homo sapiens_hsa052310.39929411
145ErbB signaling pathway_Homo sapiens_hsa040120.38464338
146Metabolic pathways_Homo sapiens_hsa011000.33315687
147Oxytocin signaling pathway_Homo sapiens_hsa049210.32950219
148Retinol metabolism_Homo sapiens_hsa008300.32760417
149Acute myeloid leukemia_Homo sapiens_hsa052210.32188642
150Systemic lupus erythematosus_Homo sapiens_hsa053220.31652481
151Insulin signaling pathway_Homo sapiens_hsa049100.30618924
152beta-Alanine metabolism_Homo sapiens_hsa004100.30209060
153Arginine biosynthesis_Homo sapiens_hsa002200.28269302
154Phototransduction_Homo sapiens_hsa047440.27843366
155Endocytosis_Homo sapiens_hsa041440.25939000
156Cyanoamino acid metabolism_Homo sapiens_hsa004600.21734380
157Taste transduction_Homo sapiens_hsa047420.20125057
158Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18989243
159Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17188746
160Fat digestion and absorption_Homo sapiens_hsa049750.17048069
161Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16192742

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