SFRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)7.89434936
2mesenchymal-epithelial cell signaling (GO:0060638)6.56287617
3regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.46912872
4cell proliferation involved in metanephros development (GO:0072203)5.38437279
5craniofacial suture morphogenesis (GO:0097094)5.36238188
6* planar cell polarity pathway involved in neural tube closure (GO:0090179)5.29678599
7cell proliferation involved in kidney development (GO:0072111)5.12390675
8mesenchymal cell proliferation (GO:0010463)5.00773655
9regulation of gene silencing by RNA (GO:0060966)4.96679458
10regulation of posttranscriptional gene silencing (GO:0060147)4.96679458
11regulation of gene silencing by miRNA (GO:0060964)4.96679458
12* regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.95358276
13sequestering of extracellular ligand from receptor (GO:0035581)4.74314805
14radial glial cell differentiation (GO:0060019)4.67786060
15negative regulation of chondrocyte differentiation (GO:0032331)4.52483204
16cranial suture morphogenesis (GO:0060363)4.49642456
17heterochromatin organization (GO:0070828)4.46442000
18notochord development (GO:0030903)4.32763660
19outer ear morphogenesis (GO:0042473)4.23385820
20* regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.13567197
21branching involved in salivary gland morphogenesis (GO:0060445)4.12023381
22establishment of integrated proviral latency (GO:0075713)4.09977527
23chondrocyte proliferation (GO:0035988)4.01068786
24pre-miRNA processing (GO:0031054)3.98453075
25paraxial mesoderm development (GO:0048339)3.97794549
26negative regulation of catenin import into nucleus (GO:0035414)3.91994230
27collagen fibril organization (GO:0030199)3.87136944
28* bone trabecula formation (GO:0060346)3.80848310
29renal system development (GO:0072001)3.79007614
30keratinocyte proliferation (GO:0043616)3.74276438
31somite development (GO:0061053)3.72079047
32endothelial cell morphogenesis (GO:0001886)3.71596628
33establishment of apical/basal cell polarity (GO:0035089)3.68223926
34G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.64257236
35negative regulation of cartilage development (GO:0061037)3.63854893
36branching involved in labyrinthine layer morphogenesis (GO:0060670)3.60090427
37embryonic cranial skeleton morphogenesis (GO:0048701)3.57125851
38cell migration involved in sprouting angiogenesis (GO:0002042)3.51833414
39hindlimb morphogenesis (GO:0035137)3.51270882
40* Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.49853637
41* regulation of non-canonical Wnt signaling pathway (GO:2000050)3.47900543
42axis elongation (GO:0003401)3.47063386
43* regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.46481855
44regulation of keratinocyte proliferation (GO:0010837)3.44709221
45axon extension involved in axon guidance (GO:0048846)3.42982551
46neuron projection extension involved in neuron projection guidance (GO:1902284)3.42982551
47lung-associated mesenchyme development (GO:0060484)3.41647574
48inner ear receptor cell development (GO:0060119)3.40410231
49* regulation of establishment of planar polarity (GO:0090175)3.37747308
50cochlea morphogenesis (GO:0090103)3.36436339
51metanephric mesenchyme development (GO:0072075)3.35466528
52proximal/distal pattern formation (GO:0009954)3.34931824
53epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.34351627
54protein heterotrimerization (GO:0070208)3.33361590
55organ induction (GO:0001759)3.32217970
56anatomical structure regression (GO:0060033)3.31886373
57organ formation (GO:0048645)3.28644757
58negative regulation of smoothened signaling pathway (GO:0045879)3.27963816
59negative regulation of embryonic development (GO:0045992)3.26405576
60regulation of catenin import into nucleus (GO:0035412)3.26047784
61establishment or maintenance of monopolar cell polarity (GO:0061339)3.25987823
62establishment of monopolar cell polarity (GO:0061162)3.25987823
63endodermal cell differentiation (GO:0035987)3.24687989
64mesenchymal cell differentiation (GO:0048762)3.24683579
65dermatan sulfate biosynthetic process (GO:0030208)3.22042847
66mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.21447697
67branch elongation of an epithelium (GO:0060602)3.20562541
68cell surface receptor signaling pathway involved in heart development (GO:0061311)3.19999359
69hippo signaling (GO:0035329)3.18720588
70mesenchyme morphogenesis (GO:0072132)3.18679532
71anterior/posterior axis specification, embryo (GO:0008595)3.18504002
72* convergent extension (GO:0060026)3.18120571
73* non-canonical Wnt signaling pathway (GO:0035567)3.16572420
74protein localization to kinetochore (GO:0034501)3.15305172
75protein complex localization (GO:0031503)3.14712888
76protein localization to cell surface (GO:0034394)3.13165519
77regulation of heart morphogenesis (GO:2000826)3.07268304
78hair follicle morphogenesis (GO:0031069)3.07098512
79limb bud formation (GO:0060174)3.07086737
80mesenchyme development (GO:0060485)3.06417774
81otic vesicle formation (GO:0030916)3.05564266
82regulation of chondrocyte differentiation (GO:0032330)3.05132846
83negative regulation of cell fate specification (GO:0009996)3.04977761
84chondrocyte development (GO:0002063)3.04023265
85kidney mesenchyme development (GO:0072074)3.03603575
86embryonic hindlimb morphogenesis (GO:0035116)3.03493827
87ventricular cardiac muscle cell development (GO:0055015)3.02961012
88regulation of cartilage development (GO:0061035)3.01043327
89generation of neurons (GO:0048699)3.01022437
90mesodermal cell differentiation (GO:0048333)2.99982145
91positive regulation of catenin import into nucleus (GO:0035413)2.99364054
92L-serine metabolic process (GO:0006563)2.98614328
93head development (GO:0060322)2.97998727
94mesonephros development (GO:0001823)2.97706670
95lens fiber cell development (GO:0070307)2.96808026
96regulation of SMAD protein import into nucleus (GO:0060390)2.96492735
97endocardial cushion morphogenesis (GO:0003203)2.95266429
98somatic stem cell division (GO:0048103)2.94434774
99glial cell migration (GO:0008347)2.94102004
100positive regulation of SMAD protein import into nucleus (GO:0060391)2.93911425
101establishment of viral latency (GO:0019043)2.93633157
102DNA unwinding involved in DNA replication (GO:0006268)2.89158139
103regulation of mesenchymal cell proliferation (GO:0010464)2.87995267
104establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.87702099
105dermatan sulfate metabolic process (GO:0030205)2.87644796
106positive regulation of mesenchymal cell proliferation (GO:0002053)2.86400886
107chromatin remodeling at centromere (GO:0031055)2.83478856
108insulin-like growth factor receptor signaling pathway (GO:0048009)2.83253984
109cartilage morphogenesis (GO:0060536)2.83139238
110bone morphogenesis (GO:0060349)2.81593010
111pharyngeal system development (GO:0060037)2.80950864
112camera-type eye morphogenesis (GO:0048593)2.80645654
113polarized epithelial cell differentiation (GO:0030859)2.80323554
114genitalia morphogenesis (GO:0035112)2.79562112
115extracellular negative regulation of signal transduction (GO:1900116)2.77987139
116extracellular regulation of signal transduction (GO:1900115)2.77987139
117positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.77659086
118* prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.76007881
119negative regulation of stem cell proliferation (GO:2000647)2.75848997
120regulation of organ formation (GO:0003156)2.75510682
121regulation of cell fate specification (GO:0042659)2.75422403
122cellular protein complex localization (GO:0034629)2.75045041
123branching involved in ureteric bud morphogenesis (GO:0001658)2.74770591
124negative regulation of gluconeogenesis (GO:0045721)2.74695698
125positive regulation of cartilage development (GO:0061036)2.74665304
126regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.74562963
127embryonic camera-type eye development (GO:0031076)2.74506656
128gap junction assembly (GO:0016264)2.66334289
129CENP-A containing nucleosome assembly (GO:0034080)2.65945629
130artery development (GO:0060840)2.65209832
131establishment of tissue polarity (GO:0007164)2.64969437
132establishment of planar polarity (GO:0001736)2.64969437
133positive regulation of cardiac muscle cell proliferation (GO:0060045)2.63644436
134nuclear pore complex assembly (GO:0051292)2.60912836
135regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.60395946
136negative regulation of translation, ncRNA-mediated (GO:0040033)2.55950402
137regulation of translation, ncRNA-mediated (GO:0045974)2.55950402
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55950402
139negative regulation of DNA repair (GO:0045738)2.53844459
140dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.53751088
141mitotic metaphase plate congression (GO:0007080)2.52533408
142* tube closure (GO:0060606)2.51456450
143establishment or maintenance of bipolar cell polarity (GO:0061245)2.50261287
144establishment or maintenance of apical/basal cell polarity (GO:0035088)2.50261287
145* neural tube closure (GO:0001843)2.48384886
146hemidesmosome assembly (GO:0031581)2.43833126
147mesenchymal to epithelial transition (GO:0060231)2.43608968
148regulation of cell fate commitment (GO:0010453)2.43115146
149negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.42350641
150regulation of stem cell maintenance (GO:2000036)2.41018663
151ATP-dependent chromatin remodeling (GO:0043044)2.39980238
152NLS-bearing protein import into nucleus (GO:0006607)2.39306631
153heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.38853218
154protein localization to chromosome, centromeric region (GO:0071459)2.38851384
155negative regulation of cell fate commitment (GO:0010454)2.37861718
156organ growth (GO:0035265)2.37764159
157regulation of gastrulation (GO:0010470)2.36134376
158adherens junction assembly (GO:0034333)2.35352472
159nuclear pore organization (GO:0006999)2.34874575
160histone exchange (GO:0043486)2.34831088
161DNA replication-independent nucleosome organization (GO:0034724)2.33895012
162DNA replication-independent nucleosome assembly (GO:0006336)2.33895012
163positive regulation of cell cycle G2/M phase transition (GO:1902751)2.33607265
164positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.33607265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.84703350
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.33168899
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.86610655
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.77149534
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.56349317
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.25711405
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.25573494
8* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.19758444
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.71866073
10* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.48567561
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.41487468
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.41487468
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.41487468
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.33741241
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30230232
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.29777305
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.28714037
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.22319474
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.21463570
20* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.17352560
21* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16126766
22AR_21909140_ChIP-Seq_LNCAP_Human2.12911807
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.12635829
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.10025106
25* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.07954464
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05006963
27* NANOG_16153702_ChIP-ChIP_HESCs_Human2.04671156
28* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01469594
29* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01469594
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00885696
31* SOX2_16153702_ChIP-ChIP_HESCs_Human2.00298756
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99872570
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.99566111
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95923594
35CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.94949908
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94840229
37* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.94766473
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.85483903
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82816514
40SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81606910
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81489814
42* EZH2_27304074_Chip-Seq_ESCs_Mouse1.81408076
43TBX3_20139965_ChIP-Seq_ESCs_Mouse1.80052699
44TBX3_20139965_ChIP-Seq_MESCs_Mouse1.78828691
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76295869
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.75937493
47* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75441038
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.72754527
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68973585
50* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.66644784
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66323492
52* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66185619
53* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64240743
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.59336629
55AR_21572438_ChIP-Seq_LNCaP_Human1.57963974
56* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57091993
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.56679163
58TP53_18474530_ChIP-ChIP_U2OS_Human1.56338797
59* EP300_21415370_ChIP-Seq_HL-1_Mouse1.54912800
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53052007
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52452840
62* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51136033
63* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50500842
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.48602509
65CJUN_26792858_Chip-Seq_BT549_Human1.47207735
66* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.46308299
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46096586
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45889001
69BRD4_25478319_ChIP-Seq_HGPS_Human1.45648084
70* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45592417
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44940105
72* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44933532
73SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.44306233
74* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.42974997
75* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.41366957
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38552235
77FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37713599
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37320923
79CLOCK_20551151_ChIP-Seq_293T_Human1.37073864
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.36322085
81* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.33780123
82AHR_22903824_ChIP-Seq_MCF-7_Human1.33244025
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32372442
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.31627724
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30332804
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.29734587
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.28948776
88TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26501064
89* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24830540
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24644272
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24633447
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23967857
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23788676
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22125105
95* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20904163
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20733309
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20588357
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.20341682
99* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19268569
100* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18506849
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17887296
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17718523
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17674238
104PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.17144712
105TP53_16413492_ChIP-PET_HCT116_Human1.15825891
106HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14845425
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.13876357
108GATA1_26923725_Chip-Seq_HPCs_Mouse1.12364128
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12069989
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.11273285
111* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10071520
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09738981
113* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08659933
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08416522
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08176707
116NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08176707
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07060769
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06179662
119NANOG_16518401_ChIP-PET_MESCs_Mouse1.05540418
120SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05211648
121CBX2_27304074_Chip-Seq_ESCs_Mouse1.03891567
122* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03544823
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.03519093
124SOX9_26525672_Chip-Seq_HEART_Mouse1.03479781
125EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03428797
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03171431
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02514598
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02281473
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00592425
130FUS_26573619_Chip-Seq_HEK293_Human1.00013594
131E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99984989
132SOX17_20123909_ChIP-Seq_XEN_Mouse0.98369249
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97576103
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97576103
135CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96622339
136SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95616853
137* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93774473
138SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93706904
139EZH2_27294783_Chip-Seq_ESCs_Mouse0.93464807
140YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93378495
141EZH2_22144423_ChIP-Seq_EOC_Human0.93009804
142* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93001796
143GBX2_23144817_ChIP-Seq_PC3_Human0.92045274
144TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91471458
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91180809
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90615170
147SA1_22415368_ChIP-Seq_MEFs_Mouse0.90507830
148ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89862261
149KAP1_27257070_Chip-Seq_ESCs_Mouse0.86610389
150MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85950163
151POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.85418036
152TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85383734
153* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85089032
154OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84843053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology5.15875399
2MP0008438_abnormal_cutaneous_collagen4.13150642
3MP0010030_abnormal_orbit_morphology3.60212163
4MP0002254_reproductive_system_inflammat3.41994868
5MP0000566_synostosis3.00733071
6MP0005275_abnormal_skin_tensile2.99865507
7MP0002938_white_spotting2.88513081
8MP0004272_abnormal_basement_membrane2.75314853
9MP0003705_abnormal_hypodermis_morpholog2.65886310
10MP0006292_abnormal_olfactory_placode2.60586251
11MP0009250_abnormal_appendicular_skeleto2.59689634
12MP0005187_abnormal_penis_morphology2.44537986
13MP0005248_abnormal_Harderian_gland2.41194421
14MP0003385_abnormal_body_wall2.31968527
15MP0005257_abnormal_intraocular_pressure2.31874556
16MP0000537_abnormal_urethra_morphology2.28320817
17MP0005508_abnormal_skeleton_morphology2.15529511
18MP0001299_abnormal_eye_distance/2.12905748
19MP0002282_abnormal_trachea_morphology2.10273589
20MP0003942_abnormal_urinary_system2.10052336
21MP0003941_abnormal_skin_development2.07883493
22MP0002249_abnormal_larynx_morphology2.04964266
23MP0009053_abnormal_anal_canal2.03237741
24MP0002108_abnormal_muscle_morphology1.97320825
25* MP0000428_abnormal_craniofacial_morphol1.96941119
26MP0001958_emphysema1.95306963
27MP0000049_abnormal_middle_ear1.94853827
28MP0004134_abnormal_chest_morphology1.89058756
29MP0003279_aneurysm1.82441710
30MP0000762_abnormal_tongue_morphology1.81513623
31MP0001293_anophthalmia1.80578154
32MP0009672_abnormal_birth_weight1.75611410
33MP0000534_abnormal_ureter_morphology1.74563363
34MP0003755_abnormal_palate_morphology1.74301894
35MP0002932_abnormal_joint_morphology1.68543507
36MP0001346_abnormal_lacrimal_gland1.66199296
37MP0008932_abnormal_embryonic_tissue1.66145023
38MP0003937_abnormal_limbs/digits/tail_de1.62484076
39MP0003890_abnormal_embryonic-extraembry1.62356003
40MP0002116_abnormal_craniofacial_bone1.60948256
41MP0009384_cardiac_valve_regurgitation1.56292923
42MP0003935_abnormal_craniofacial_develop1.53222299
43MP0000516_abnormal_urinary_system1.52251302
44MP0005367_renal/urinary_system_phenotyp1.52251302
45MP0004957_abnormal_blastocyst_morpholog1.51941130
46MP0002697_abnormal_eye_size1.49410746
47MP0003693_abnormal_embryo_hatching1.48292222
48MP0010368_abnormal_lymphatic_system1.47753161
49MP0002233_abnormal_nose_morphology1.47709532
50MP0003938_abnormal_ear_development1.47098604
51MP0003115_abnormal_respiratory_system1.44933317
52MP0000579_abnormal_nail_morphology1.42124188
53MP0003111_abnormal_nucleus_morphology1.36284901
54MP0000163_abnormal_cartilage_morphology1.33013978
55MP0000432_abnormal_head_morphology1.32875092
56MP0003136_yellow_coat_color1.30711892
57MP0002896_abnormal_bone_mineralization1.29019148
58MP0002295_abnormal_pulmonary_circulatio1.26314404
59MP0005623_abnormal_meninges_morphology1.26034140
60MP0002092_abnormal_eye_morphology1.24815726
61MP0002115_abnormal_skeleton_extremities1.23623485
62* MP0002109_abnormal_limb_morphology1.21961137
63MP0003878_abnormal_ear_physiology1.21698951
64MP0005377_hearing/vestibular/ear_phenot1.21698951
65* MP0002084_abnormal_developmental_patter1.19936677
66MP0004858_abnormal_nervous_system1.19577757
67MP0006054_spinal_hemorrhage1.19544096
68MP0000647_abnormal_sebaceous_gland1.19252618
69MP0008789_abnormal_olfactory_epithelium1.18614758
70MP0003122_maternal_imprinting1.18489591
71MP0002177_abnormal_outer_ear1.14243187
72MP0005076_abnormal_cell_differentiation1.10446679
73MP0005197_abnormal_uvea_morphology1.10237066
74MP0001340_abnormal_eyelid_morphology1.08589209
75MP0001849_ear_inflammation1.07012297
76MP0002060_abnormal_skin_morphology1.06860607
77MP0002113_abnormal_skeleton_development1.05952501
78MP0001730_embryonic_growth_arrest1.05503238
79MP0005394_taste/olfaction_phenotype1.05255345
80MP0005499_abnormal_olfactory_system1.05255345
81MP0002111_abnormal_tail_morphology1.04908811
82MP0000733_abnormal_muscle_development1.02599046
83* MP0003861_abnormal_nervous_system1.00599170
84MP0003283_abnormal_digestive_organ0.97089900
85MP0003119_abnormal_digestive_system0.96210535
86MP0000427_abnormal_hair_cycle0.95539864
87MP0001286_abnormal_eye_development0.94432695
88MP0002098_abnormal_vibrissa_morphology0.93654725
89MP0010094_abnormal_chromosome_stability0.91392709
90* MP0005380_embryogenesis_phenotype0.90871750
91* MP0001672_abnormal_embryogenesis/_devel0.90871750
92MP0000778_abnormal_nervous_system0.89876780
93* MP0002114_abnormal_axial_skeleton0.89645831
94MP0001177_atelectasis0.88639940
95MP0003077_abnormal_cell_cycle0.87865522
96MP0003123_paternal_imprinting0.87780401
97MP0000383_abnormal_hair_follicle0.86771305
98MP0002751_abnormal_autonomic_nervous0.86577296
99MP0005023_abnormal_wound_healing0.84305045
100MP0000751_myopathy0.83908228
101MP0000462_abnormal_digestive_system0.83421517
102MP0001243_abnormal_dermal_layer0.83300937
103MP0001697_abnormal_embryo_size0.81560926
104MP0001270_distended_abdomen0.81483795
105MP0010352_gastrointestinal_tract_polyps0.81475258
106MP0005390_skeleton_phenotype0.81399818
107MP0000350_abnormal_cell_proliferation0.81097410
108MP0004197_abnormal_fetal_growth/weight/0.81073984
109MP0002009_preneoplasia0.80859267
110MP0003566_abnormal_cell_adhesion0.80526036
111MP0003121_genomic_imprinting0.79962807
112MP0002089_abnormal_postnatal_growth/wei0.78736252
113* MP0003984_embryonic_growth_retardation0.78576744
114MP0003315_abnormal_perineum_morphology0.78403909
115MP0005193_abnormal_anterior_eye0.76590141
116* MP0002085_abnormal_embryonic_tissue0.76409495
117MP0002796_impaired_skin_barrier0.76234837
118MP0000613_abnormal_salivary_gland0.76084576
119* MP0002088_abnormal_embryonic_growth/wei0.74802059
120MP0001661_extended_life_span0.74327315
121MP0000767_abnormal_smooth_muscle0.73749814
122MP0002925_abnormal_cardiovascular_devel0.73299025
123MP0000678_abnormal_parathyroid_gland0.72004213
124MP0009703_decreased_birth_body0.70900073
125MP0003091_abnormal_cell_migration0.70777792
126MP0001175_abnormal_lung_morphology0.70705628
127* MP0002080_prenatal_lethality0.70486410
128MP0002081_perinatal_lethality0.70161826
129MP0003567_abnormal_fetal_cardiomyocyte0.68525064
130MP0004133_heterotaxia0.66964566
131MP0002102_abnormal_ear_morphology0.66951150
132MP0005220_abnormal_exocrine_pancreas0.66564691

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)5.60511006
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.60511006
3Abnormality of the parietal bone (HP:0002696)4.76882697
4Shallow orbits (HP:0000586)4.63414117
5Protrusio acetabuli (HP:0003179)4.43400206
6Midline defect of the nose (HP:0004122)4.34597245
7Broad metatarsal (HP:0001783)4.09693607
8Abnormality of the 4th metacarpal (HP:0010012)4.06105771
9Septo-optic dysplasia (HP:0100842)3.61989277
10Trigonocephaly (HP:0000243)3.61664364
11Premature rupture of membranes (HP:0001788)3.39265725
12Abnormality of the diencephalon (HP:0010662)3.36242711
13Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.32833013
14Selective tooth agenesis (HP:0001592)2.96544483
15Down-sloping shoulders (HP:0200021)2.96417561
16Coronal craniosynostosis (HP:0004440)2.93330268
17Nasolacrimal duct obstruction (HP:0000579)2.90524315
18Abnormality of the distal phalanx of the thumb (HP:0009617)2.89306247
19Abnormality of the nasal septum (HP:0000419)2.84400201
20Abnormal number of incisors (HP:0011064)2.77242571
21Bell-shaped thorax (HP:0001591)2.73271112
22Aplasia involving bones of the extremities (HP:0009825)2.72061356
23Aplasia involving bones of the upper limbs (HP:0009823)2.72061356
24Aplasia of the phalanges of the hand (HP:0009802)2.72061356
25Alacrima (HP:0000522)2.71116156
26Hepatoblastoma (HP:0002884)2.68717315
27Microglossia (HP:0000171)2.68057717
28Short phalanx of the thumb (HP:0009660)2.66112124
29Supernumerary ribs (HP:0005815)2.64143537
30Abnormality of the lacrimal duct (HP:0011481)2.62974771
31Broad toe (HP:0001837)2.62532058
32Abnormality of the nasolacrimal system (HP:0000614)2.61595011
33Short hallux (HP:0010109)2.57250531
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.56582034
35Neoplasm of the heart (HP:0100544)2.55302455
36Natal tooth (HP:0000695)2.54183592
37Ankle contracture (HP:0006466)2.46672307
38Broad hallux (HP:0010055)2.42910618
39Hypoplastic labia majora (HP:0000059)2.39647676
40Aortic dissection (HP:0002647)2.36747637
41Maternal diabetes (HP:0009800)2.35411275
42Aplasia/Hypoplasia of the hallux (HP:0008362)2.34565309
43Abnormality of the incisor (HP:0000676)2.32540278
44Wide anterior fontanel (HP:0000260)2.30963615
45Supernumerary bones of the axial skeleton (HP:0009144)2.30956444
46Partial duplication of the phalanx of hand (HP:0009999)2.30684106
47Abnormality of the labia minora (HP:0012880)2.29034997
48Vascular tortuosity (HP:0004948)2.26640374
49Bladder diverticulum (HP:0000015)2.25262625
50Soft skin (HP:0000977)2.24759164
51Arnold-Chiari malformation (HP:0002308)2.24601871
52Bilateral microphthalmos (HP:0007633)2.24295978
53Arterial tortuosity (HP:0005116)2.24124041
54Atrophic scars (HP:0001075)2.23862758
55Colon cancer (HP:0003003)2.23620141
56Abnormality of the labia majora (HP:0012881)2.22825869
57Neonatal short-limb short stature (HP:0008921)2.20896086
58Turricephaly (HP:0000262)2.20583697
59Exostoses (HP:0100777)2.17915202
60Cervical subluxation (HP:0003308)2.15406994
61Broad face (HP:0000283)2.14574520
62Humeroradial synostosis (HP:0003041)2.11435649
63Synostosis involving the elbow (HP:0003938)2.11435649
64Aplasia/Hypoplasia of the breasts (HP:0010311)2.11210920
65Decreased lacrimation (HP:0000633)2.10906711
66Anteriorly placed anus (HP:0001545)2.10589151
67Mesomelia (HP:0003027)2.09026115
68Abnormal lung lobation (HP:0002101)2.07854590
69Renal duplication (HP:0000075)2.07702011
70Spastic diplegia (HP:0001264)2.06870849
71Abnormality of the antihelix (HP:0009738)2.06664315
72Vitreoretinal degeneration (HP:0000655)2.05361035
73Breast aplasia (HP:0100783)2.05094775
74Partial duplication of thumb phalanx (HP:0009944)2.04050228
75Abnormality of incisor morphology (HP:0011063)2.03323223
76Nuclear cataract (HP:0100018)2.02197803
77Duplication of thumb phalanx (HP:0009942)2.01667412
78Preaxial foot polydactyly (HP:0001841)2.00900933
79Ulnar bowing (HP:0003031)2.00797516
80Aortic aneurysm (HP:0004942)1.99124372
81Neoplasm of the oral cavity (HP:0100649)1.97981928
82Overgrowth (HP:0001548)1.97547782
83Hypoplastic ischia (HP:0003175)1.96923247
84Spinal rigidity (HP:0003306)1.96868063
85Peritonitis (HP:0002586)1.95068200
86Bowel diverticulosis (HP:0005222)1.93867778
87Abnormality of dentin (HP:0010299)1.93303381
88Broad long bones (HP:0005622)1.91860298
89Follicular hyperkeratosis (HP:0007502)1.91594435
90Aplasia cutis congenita (HP:0001057)1.91544489
91Increased nuchal translucency (HP:0010880)1.91494840
92Anophthalmia (HP:0000528)1.91433097
93Broad thumb (HP:0011304)1.91055003
94Bronchomalacia (HP:0002780)1.90648450
95Deviation of the hallux (HP:0010051)1.90439525
96Narrow palate (HP:0000189)1.90406514
97Hypoplasia of the maxilla (HP:0000327)1.89953709
98Infantile muscular hypotonia (HP:0008947)1.89744102
99Hemivertebrae (HP:0002937)1.87678349
100Absent septum pellucidum (HP:0001331)1.87228381
101Hyperextensible skin (HP:0000974)1.86909090
102Cutaneous syndactyly (HP:0012725)1.86269182
103Decreased skull ossification (HP:0004331)1.85865705
104Choanal stenosis (HP:0000452)1.84648319
105Milia (HP:0001056)1.84300812
106Large earlobe (HP:0009748)1.83511272
107Toxemia of pregnancy (HP:0100603)1.83052763
108Abnormality of the middle phalanges of the hand (HP:0009833)1.82261215
109Increased number of teeth (HP:0011069)1.82228913
110Overriding aorta (HP:0002623)1.81649348
111Mitral valve prolapse (HP:0001634)1.81276485
112Abnormality of the middle phalanges of the toes (HP:0010183)1.80891539
113Fragile skin (HP:0001030)1.79604012
114Broad phalanx (HP:0006009)1.78457962
115Aqueductal stenosis (HP:0002410)1.78380662
116Wide cranial sutures (HP:0010537)1.78280803
117Blue sclerae (HP:0000592)1.77325408
118Medulloblastoma (HP:0002885)1.76366131
119Morphological abnormality of the middle ear (HP:0008609)1.75151371
120Broad ribs (HP:0000885)1.75055434
121Hallux valgus (HP:0001822)1.74224957
122Broad finger (HP:0001500)1.73610445
123Mixed hearing impairment (HP:0000410)1.73583029
124Bifid tongue (HP:0010297)1.73568337
125Abnormality of the septum pellucidum (HP:0007375)1.72105915
126Vertebral arch anomaly (HP:0008438)1.71713700
127Abnormality of the ischium (HP:0003174)1.71440727
128Cutaneous finger syndactyly (HP:0010554)1.71211123
129Broad phalanges of the hand (HP:0009768)1.71031075
130Vertebral clefting (HP:0008428)1.70977803
131Genu recurvatum (HP:0002816)1.70302325
132Biconcave vertebral bodies (HP:0004586)1.68511706
133Camptodactyly of toe (HP:0001836)1.68127879
134Optic nerve hypoplasia (HP:0000609)1.67681787
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67651662
136Advanced eruption of teeth (HP:0006288)1.67139184
137Pterygium (HP:0001059)1.66594252
138Esophageal atresia (HP:0002032)1.66102835
139Disproportionate tall stature (HP:0001519)1.64563551
140Ectopia lentis (HP:0001083)1.63750857
141Syringomyelia (HP:0003396)1.62416692
142Spinal cord lesions (HP:0100561)1.62416692
143Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.62128067
144Myelomeningocele (HP:0002475)1.62121201
145Ependymoma (HP:0002888)1.61928009
146Wormian bones (HP:0002645)1.61871750
147High anterior hairline (HP:0009890)1.61766416
148Facial cleft (HP:0002006)1.59530654
149Short middle phalanx of finger (HP:0005819)1.58632443
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.58460536
151Synostosis of carpal bones (HP:0005048)1.57166615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.66894214
2LATS15.36423604
3FGFR24.09763873
4EPHB23.62662973
5PDGFRA3.17952461
6CDC73.03890998
7EPHA32.94164027
8LATS22.91229549
9SIK12.89229505
10BUB12.39769941
11FGFR12.31737800
12TAF12.17723341
13MYLK2.04385247
14VRK21.97824489
15STK38L1.93569547
16TNIK1.90502870
17CDK121.70832422
18STK31.69358260
19FER1.67224010
20SMG11.65947595
21WEE11.61170101
22BRSK21.60068990
23TSSK61.59408789
24PIK3CA1.56321317
25ERBB41.49866966
26BMX1.45600500
27PNCK1.40165548
28TRIB31.39068081
29RIPK11.33108927
30CDK61.29192795
31FLT31.27696091
32ERBB31.27163602
33NEK21.25983678
34PDGFRB1.23992440
35EPHA41.20989997
36SRPK11.20104943
37NUAK11.16883268
38PLK11.10233183
39TTN1.08906449
40NLK1.07813939
41PBK1.06225526
42DMPK1.04505294
43MTOR1.04461063
44MKNK11.03185782
45EEF2K1.02088404
46TGFBR10.98735693
47PLK40.97041630
48PTK60.93727135
49CAMK1D0.91338306
50TYRO30.90967931
51PTK20.89959560
52MET0.89756207
53PAK20.89539813
54CASK0.88819008
55ERBB20.87940446
56BRD40.87743408
57WNK10.87523854
58CAMK1G0.86696769
59CSNK1A1L0.84377177
60ROCK10.84020970
61PRKD30.82860404
62CDK70.82394627
63DYRK20.81769508
64MKNK20.79013264
65PAK30.78603935
66FGFR30.78281673
67PAK40.78166990
68TGFBR20.76339341
69PKN20.74266016
70CDC42BPA0.73515104
71CAMK40.72330238
72PASK0.71925867
73CDK190.70468466
74BRSK10.70106012
75ICK0.69833719
76MAP3K100.66752166
77NEK10.66725380
78PLK30.65925863
79GSK3A0.64525755
80MAP3K90.64426768
81WNK40.62149928
82AURKB0.61221564
83LIMK10.60085347
84PLK20.59297906
85AKT30.59074842
86SGK30.57956442
87CHUK0.57269243
88PRKD20.57114486
89NEK90.57054144
90VRK10.55481271
91ATR0.55345853
92CLK10.55163966
93CSNK1G10.54814525
94ACVR1B0.54581348
95SGK20.54296869
96EIF2AK20.54263511
97ERN10.54067784
98MAP3K80.53899659
99CHEK10.53155053
100RPS6KA40.53051004
101LRRK20.51766075
102LMTK20.51294886
103WNK30.50770988
104STK40.49814722
105ALK0.48895162
106MARK10.48853690
107CHEK20.48624448
108BMPR1B0.48015933
109EPHB10.47458402
110MAPK10.47261088
111PRKDC0.46599985
112MOS0.46303775
113ROCK20.45975731
114RPS6KB20.44444043
115PRKD10.43707135
116STK240.43460054
117TIE10.41986671
118TTK0.41517788
119RPS6KA20.40909416
120CSNK1E0.40380543
121BRAF0.39995850
122CDK10.39787022
123CDK150.39613329
124CDK11A0.39322220
125CSNK1D0.38905564
126RET0.38726318
127CDK180.38427924
128BCR0.38289257
129HIPK20.37795693
130ADRBK10.37686773
131STK380.37207055
132PAK10.37060410
133INSR0.36665997
134DYRK1B0.36179533
135DYRK30.35899941
136MAPK80.34931302
137MAPK150.34515497
138AKT10.33247028
139RPS6KL10.32793903
140RPS6KC10.32793903
141IGF1R0.32768081
142ATM0.31409351
143EPHA20.31318045
144PRKCH0.31075417
145IRAK10.30523427
146KSR10.30278309
147PRKCE0.30219532
148ZAK0.30032769
149NTRK10.29551999
150MAPK140.29531573
151CDK40.29407807

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052175.26117970
2Hedgehog signaling pathway_Homo sapiens_hsa043404.43911026
3ECM-receptor interaction_Homo sapiens_hsa045123.29799138
4Hippo signaling pathway_Homo sapiens_hsa043902.91289317
5TGF-beta signaling pathway_Homo sapiens_hsa043502.78980541
6Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.55639780
7Adherens junction_Homo sapiens_hsa045202.51555453
8DNA replication_Homo sapiens_hsa030302.39696005
9Mismatch repair_Homo sapiens_hsa034302.36799303
10* Wnt signaling pathway_Homo sapiens_hsa043102.34083524
11Protein digestion and absorption_Homo sapiens_hsa049742.25129086
12Melanoma_Homo sapiens_hsa052182.24034915
13Focal adhesion_Homo sapiens_hsa045102.15664954
14Proteoglycans in cancer_Homo sapiens_hsa052052.05451679
15Prostate cancer_Homo sapiens_hsa052151.94546098
16Non-homologous end-joining_Homo sapiens_hsa034501.93199237
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.92828708
18Pathways in cancer_Homo sapiens_hsa052001.91608851
19MicroRNAs in cancer_Homo sapiens_hsa052061.83523226
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.76030763
21Small cell lung cancer_Homo sapiens_hsa052221.70094694
22Colorectal cancer_Homo sapiens_hsa052101.69774273
23Axon guidance_Homo sapiens_hsa043601.68681486
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.52965210
25Melanogenesis_Homo sapiens_hsa049161.52879512
26Notch signaling pathway_Homo sapiens_hsa043301.52375760
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.50305667
28Dilated cardiomyopathy_Homo sapiens_hsa054141.45027848
29Amoebiasis_Homo sapiens_hsa051461.44920019
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41965243
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41503832
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38805818
33Chronic myeloid leukemia_Homo sapiens_hsa052201.36465791
34Endometrial cancer_Homo sapiens_hsa052131.36265066
35Lysine degradation_Homo sapiens_hsa003101.31819181
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29693841
37Bladder cancer_Homo sapiens_hsa052191.28633081
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.26909359
39Base excision repair_Homo sapiens_hsa034101.25376710
40Nucleotide excision repair_Homo sapiens_hsa034201.23852340
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23600096
42Biosynthesis of amino acids_Homo sapiens_hsa012301.23591749
43Rap1 signaling pathway_Homo sapiens_hsa040151.20116606
44Selenocompound metabolism_Homo sapiens_hsa004501.16548922
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16031062
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15712061
47Steroid biosynthesis_Homo sapiens_hsa001001.15669260
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14911719
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14250479
50HTLV-I infection_Homo sapiens_hsa051661.10713636
51Glioma_Homo sapiens_hsa052141.09267961
52Tight junction_Homo sapiens_hsa045301.09118245
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06827517
54Homologous recombination_Homo sapiens_hsa034401.06568031
55Cell cycle_Homo sapiens_hsa041101.04473552
56Vitamin B6 metabolism_Homo sapiens_hsa007501.04437364
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02324226
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.00843076
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99465761
60Pyruvate metabolism_Homo sapiens_hsa006200.99318590
61Viral myocarditis_Homo sapiens_hsa054160.98117758
62RNA polymerase_Homo sapiens_hsa030200.91547602
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90033363
64Renal cell carcinoma_Homo sapiens_hsa052110.89903692
65Basal transcription factors_Homo sapiens_hsa030220.89430063
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88191231
67One carbon pool by folate_Homo sapiens_hsa006700.81719620
68Pancreatic cancer_Homo sapiens_hsa052120.81409576
69Toxoplasmosis_Homo sapiens_hsa051450.80687748
70Fanconi anemia pathway_Homo sapiens_hsa034600.78703704
71mTOR signaling pathway_Homo sapiens_hsa041500.76093708
72Malaria_Homo sapiens_hsa051440.75633574
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75005339
74p53 signaling pathway_Homo sapiens_hsa041150.74891985
75RNA degradation_Homo sapiens_hsa030180.74777964
76FoxO signaling pathway_Homo sapiens_hsa040680.74678780
77Thyroid cancer_Homo sapiens_hsa052160.74542633
78Ras signaling pathway_Homo sapiens_hsa040140.72085631
79Protein export_Homo sapiens_hsa030600.71749149
80ErbB signaling pathway_Homo sapiens_hsa040120.70821913
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70037534
82Estrogen signaling pathway_Homo sapiens_hsa049150.69652083
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69326286
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67899411
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63213497
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62843701
87MAPK signaling pathway_Homo sapiens_hsa040100.62705503
88AMPK signaling pathway_Homo sapiens_hsa041520.61526400
89Carbon metabolism_Homo sapiens_hsa012000.61443626
90Gap junction_Homo sapiens_hsa045400.60137838
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60014047
92TNF signaling pathway_Homo sapiens_hsa046680.59682496
93cAMP signaling pathway_Homo sapiens_hsa040240.59185217
94Insulin resistance_Homo sapiens_hsa049310.58700732
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.58590299
96Non-small cell lung cancer_Homo sapiens_hsa052230.58423665
97mRNA surveillance pathway_Homo sapiens_hsa030150.57249313
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56207434
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.53865842
100N-Glycan biosynthesis_Homo sapiens_hsa005100.52774709
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50410118
102Ribosome_Homo sapiens_hsa030100.48645973
103Acute myeloid leukemia_Homo sapiens_hsa052210.47435838
104Pyrimidine metabolism_Homo sapiens_hsa002400.47326661
105Proteasome_Homo sapiens_hsa030500.46821651
106Vitamin digestion and absorption_Homo sapiens_hsa049770.46676092
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45335077
108Ovarian steroidogenesis_Homo sapiens_hsa049130.44244497
109Hepatitis B_Homo sapiens_hsa051610.44025235
110Prolactin signaling pathway_Homo sapiens_hsa049170.43682200
111Choline metabolism in cancer_Homo sapiens_hsa052310.43065323
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42187246
113Propanoate metabolism_Homo sapiens_hsa006400.42109285
114Fatty acid elongation_Homo sapiens_hsa000620.41627888
115Glutathione metabolism_Homo sapiens_hsa004800.41394621
116Insulin signaling pathway_Homo sapiens_hsa049100.40294055
117Glucagon signaling pathway_Homo sapiens_hsa049220.39995695
118Pentose phosphate pathway_Homo sapiens_hsa000300.37071205
119HIF-1 signaling pathway_Homo sapiens_hsa040660.36807442
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35976891
121Purine metabolism_Homo sapiens_hsa002300.34593965
122Folate biosynthesis_Homo sapiens_hsa007900.34520908
123Dorso-ventral axis formation_Homo sapiens_hsa043200.34270164
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34180559
125Type II diabetes mellitus_Homo sapiens_hsa049300.33411021
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33107844
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.32847744
128Viral carcinogenesis_Homo sapiens_hsa052030.29294271
129Renin secretion_Homo sapiens_hsa049240.28712214
130Oocyte meiosis_Homo sapiens_hsa041140.27892157
131GnRH signaling pathway_Homo sapiens_hsa049120.27479228
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27170808
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27116034
134Spliceosome_Homo sapiens_hsa030400.26977026
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.25702178
136RNA transport_Homo sapiens_hsa030130.22519979
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20947524
138Platelet activation_Homo sapiens_hsa046110.20372101
139Endocytosis_Homo sapiens_hsa041440.18305559
140Thyroid hormone synthesis_Homo sapiens_hsa049180.18208016

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