SFI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.96686593
2tolerance induction (GO:0002507)4.67968944
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.40287152
4behavioral response to nicotine (GO:0035095)4.33115039
5histone H3-K4 trimethylation (GO:0080182)4.23419935
6fucose catabolic process (GO:0019317)4.00573770
7L-fucose metabolic process (GO:0042354)4.00573770
8L-fucose catabolic process (GO:0042355)4.00573770
9activated T cell proliferation (GO:0050798)3.98386526
10negative regulation of cell killing (GO:0031342)3.95946663
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95946663
12sulfation (GO:0051923)3.93138136
13cellular response to exogenous dsRNA (GO:0071360)3.86720862
14G-protein coupled receptor internalization (GO:0002031)3.74624438
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57431379
16negative regulation of granulocyte differentiation (GO:0030853)3.54469545
17histone H3-K36 demethylation (GO:0070544)3.53704562
18positive regulation of defense response to virus by host (GO:0002230)3.53092449
19cellular response to ATP (GO:0071318)3.49941131
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.47078068
21regulation of gamma-delta T cell activation (GO:0046643)3.39935811
22regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.38422593
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.37046299
24regulation of translation, ncRNA-mediated (GO:0045974)3.37046299
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.37046299
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33253138
27modulation by virus of host process (GO:0019054)3.33074388
28regulation of B cell receptor signaling pathway (GO:0050855)3.28366470
29regulation of histone H3-K27 methylation (GO:0061085)3.24314473
30superoxide anion generation (GO:0042554)3.21541896
31peptidyl-lysine trimethylation (GO:0018023)3.20252959
32mature B cell differentiation (GO:0002335)3.19881321
33histone H3-K4 methylation (GO:0051568)3.14591979
34positive regulation of granulocyte differentiation (GO:0030854)3.09694203
35positive regulation of CREB transcription factor activity (GO:0032793)3.09660424
36detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.07938088
37modulation by symbiont of host cellular process (GO:0044068)3.06327211
38negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.06233438
39regulation of alpha-beta T cell proliferation (GO:0046640)3.02204147
40CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.01611875
41cellular response to interleukin-15 (GO:0071350)3.01217089
42germinal center formation (GO:0002467)3.00694218
43negative regulation of T cell mediated immunity (GO:0002710)2.98683723
44positive thymic T cell selection (GO:0045059)2.97969235
45kynurenine metabolic process (GO:0070189)2.95603717
46DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.95186969
47positive regulation of humoral immune response (GO:0002922)2.93214085
48regulation of T cell mediated cytotoxicity (GO:0001914)2.92992131
49detection of bacterium (GO:0016045)2.92478564
50positive regulation of T cell mediated cytotoxicity (GO:0001916)2.92106370
51DNA deamination (GO:0045006)2.91697074
52histone H3-K9 demethylation (GO:0033169)2.89897542
53indolalkylamine metabolic process (GO:0006586)2.89539000
54regulation of gamma-delta T cell differentiation (GO:0045586)2.89280204
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.89268780
56positive regulation of antigen processing and presentation (GO:0002579)2.87313530
57regulation of regulatory T cell differentiation (GO:0045589)2.85013915
58detection of other organism (GO:0098543)2.83825514
59histone lysine demethylation (GO:0070076)2.81560681
60tryptophan metabolic process (GO:0006568)2.81466773
61positive regulation of cellular amide metabolic process (GO:0034250)2.76225936
62B cell receptor signaling pathway (GO:0050853)2.73729775
63positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.73236623
64regulation of memory T cell differentiation (GO:0043380)2.73008129
65mast cell activation involved in immune response (GO:0002279)2.72853262
66mast cell degranulation (GO:0043303)2.72853262
67regulation of granulocyte differentiation (GO:0030852)2.72704876
68detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.70814468
69mast cell activation (GO:0045576)2.70319948
70phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.69551940
71B cell homeostasis (GO:0001782)2.67258402
72positive regulation of fatty acid beta-oxidation (GO:0032000)2.67131389
73amino sugar catabolic process (GO:0046348)2.66699949
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.66663884
75positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66031219
76DNA damage response, signal transduction resulting in transcription (GO:0042772)2.65869269
77regulation of defense response to virus by host (GO:0050691)2.65251205
78regulation of MHC class I biosynthetic process (GO:0045343)2.65074056
79meiotic chromosome segregation (GO:0045132)2.64907113
80response to peptidoglycan (GO:0032494)2.64316488
81negative regulation of lymphocyte mediated immunity (GO:0002707)2.63409009
82histone demethylation (GO:0016577)2.63121249
83alpha-beta T cell differentiation (GO:0046632)2.63041718
84response to interleukin-15 (GO:0070672)2.61617330
85cytidine deamination (GO:0009972)2.61102127
86cytidine metabolic process (GO:0046087)2.61102127
87cytidine catabolic process (GO:0006216)2.61102127
88regulation of isotype switching to IgG isotypes (GO:0048302)2.60442005
89positive regulation of calcium-mediated signaling (GO:0050850)2.59357734
903-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.59045052
91purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.59045052
92negative regulation of DNA-dependent DNA replication (GO:2000104)2.58844845
93positive T cell selection (GO:0043368)2.57932233
94energy homeostasis (GO:0097009)2.57731598
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.57722504
96negative regulation of T-helper cell differentiation (GO:0045623)2.57722504
97response to muramyl dipeptide (GO:0032495)2.55737598
98positive regulation of interleukin-1 beta secretion (GO:0050718)2.55509485
99purinergic nucleotide receptor signaling pathway (GO:0035590)2.55354184
100interferon-gamma secretion (GO:0072643)2.54808252
101pyrimidine ribonucleoside catabolic process (GO:0046133)2.54082622
102regulation of antigen processing and presentation (GO:0002577)2.53753909
103positive regulation of fatty acid oxidation (GO:0046321)2.53731507
104negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.51911504
105leukocyte aggregation (GO:0070486)2.51396554
106NIK/NF-kappaB signaling (GO:0038061)2.51341246
107female gonad development (GO:0008585)2.51308507
108negative T cell selection (GO:0043383)2.50223049
109regulation of leukocyte mediated cytotoxicity (GO:0001910)2.50010826
110thymic T cell selection (GO:0045061)2.49724301
111negative thymic T cell selection (GO:0045060)2.49578457
112positive regulation of cholesterol efflux (GO:0010875)2.48883711
113detection of chemical stimulus involved in sensory perception (GO:0050907)2.48635058
114androgen biosynthetic process (GO:0006702)2.48350005
115positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.47899038
116regulation of interleukin-12 biosynthetic process (GO:0045075)2.47738497
117positive regulation of T-helper 1 type immune response (GO:0002827)2.46902689
118regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.46507559
119regulation of natural killer cell mediated immunity (GO:0002715)2.46507559
120interkinetic nuclear migration (GO:0022027)2.45875788
121antigen receptor-mediated signaling pathway (GO:0050851)2.45789086
122interferon-gamma production (GO:0032609)2.45188099
123regulation of dendritic cell antigen processing and presentation (GO:0002604)2.44532499
124positive regulation of interferon-alpha production (GO:0032727)2.43932297
125antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43904647
126regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.43534205
127poly(A)+ mRNA export from nucleus (GO:0016973)2.42813016
128regulation of T cell receptor signaling pathway (GO:0050856)2.42615175
129regulation of T-helper 1 type immune response (GO:0002825)2.42539096
130positive regulation of interleukin-1 secretion (GO:0050716)2.42371107
131defense response to protozoan (GO:0042832)2.42110841
132NAD biosynthetic process (GO:0009435)2.42079103
133regulation of platelet aggregation (GO:0090330)2.41475877
134positive regulation of cAMP-mediated signaling (GO:0043950)2.41203098
135negative regulation of nitric oxide biosynthetic process (GO:0045019)2.40818621
136negative regulation of cAMP-mediated signaling (GO:0043951)2.40719288
137indole-containing compound catabolic process (GO:0042436)2.40675715
138indolalkylamine catabolic process (GO:0046218)2.40675715
139tryptophan catabolic process (GO:0006569)2.40675715
140Peyers patch development (GO:0048541)2.40541418
141mucosal-associated lymphoid tissue development (GO:0048537)2.40541418
142T cell selection (GO:0045058)2.40504090
143detection of molecule of bacterial origin (GO:0032490)2.40172566
144regulation of B cell differentiation (GO:0045577)2.40007594
145protein K48-linked deubiquitination (GO:0071108)2.39942204
146replicative senescence (GO:0090399)2.39735493
147regulation of interleukin-1 beta secretion (GO:0050706)2.37939335
148regulation of cell killing (GO:0031341)2.37573432
149regulation of interferon-alpha production (GO:0032647)2.37295589
150antigen processing and presentation of endogenous antigen (GO:0019883)2.34780507
151negative regulation of keratinocyte proliferation (GO:0010839)2.33915974
152oligosaccharide catabolic process (GO:0009313)2.33516699
153sulfate transmembrane transport (GO:1902358)2.30854723
154B cell differentiation (GO:0030183)2.29646866
155sulfate transport (GO:0008272)2.29395668
156positive regulation of B cell differentiation (GO:0045579)2.28368424
157left/right axis specification (GO:0070986)2.27844482
158DNA integration (GO:0015074)2.27790326
159mature B cell differentiation involved in immune response (GO:0002313)2.27624123
160histone H4-K12 acetylation (GO:0043983)2.26771797
161cellular biogenic amine catabolic process (GO:0042402)2.26009159
162amine catabolic process (GO:0009310)2.26009159
163detection of external biotic stimulus (GO:0098581)2.25161484
164response to host immune response (GO:0052572)2.24157468
165response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.24157468
166histone H3-K9 methylation (GO:0051567)2.23574697
167T cell migration (GO:0072678)2.22887992
168histone H3-K9 modification (GO:0061647)2.22656139
169positive regulation by organism of defense response of other organism involved in symbiotic interact2.21695054
170modulation by symbiont of host immune response (GO:0052553)2.21695054
171positive regulation by symbiont of host defense response (GO:0052509)2.21695054
172modulation by symbiont of host defense response (GO:0052031)2.21695054
173modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.21695054
174modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.21695054
175regulation of germinal center formation (GO:0002634)2.21502399

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.13531876
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.84613759
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65914127
4SUZ12_27294783_Chip-Seq_NPCs_Mouse2.55923735
5NFE2_27457419_Chip-Seq_LIVER_Mouse2.55155990
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.51973848
7PCGF2_27294783_Chip-Seq_NPCs_Mouse2.50545026
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44586541
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.37792543
10EZH2_22144423_ChIP-Seq_EOC_Human2.35246609
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.34340779
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.23598998
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20841894
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18955194
15ZNF274_21170338_ChIP-Seq_K562_Hela2.09863625
16EZH2_27294783_Chip-Seq_NPCs_Mouse2.08145218
17* SCL_19346495_ChIP-Seq_HPC-7_Human1.99800197
18IRF8_21731497_ChIP-ChIP_J774_Mouse1.95775747
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89527814
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84979412
21GATA3_27048872_Chip-Seq_THYMUS_Human1.82931242
22VDR_21846776_ChIP-Seq_THP-1_Human1.82728348
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82574278
24* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.81243650
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.80554886
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.77059843
27GBX2_23144817_ChIP-Seq_PC3_Human1.76923535
28MAF_26560356_Chip-Seq_TH1_Human1.76714886
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75878754
30UTX_26944678_Chip-Seq_JUKART_Human1.73624999
31NMYC_18555785_Chip-Seq_ESCs_Mouse1.71248182
32MAF_26560356_Chip-Seq_TH2_Human1.67562095
33* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.65597968
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.65201253
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64434725
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.64264319
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62016970
38P53_22387025_ChIP-Seq_ESCs_Mouse1.61664521
39STAT3_18555785_Chip-Seq_ESCs_Mouse1.61574651
40* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.60801338
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60676080
42SUZ12_18555785_Chip-Seq_ESCs_Mouse1.60279527
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57358868
44GATA3_26560356_Chip-Seq_TH2_Human1.57073836
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56780473
46MYC_22102868_ChIP-Seq_BL_Human1.56375781
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55810026
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55687400
49OCT4_18555785_Chip-Seq_ESCs_Mouse1.54154094
50ESRRB_18555785_Chip-Seq_ESCs_Mouse1.53247237
51RUNX1_27457419_Chip-Seq_LIVER_Mouse1.52765737
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.52236001
53ZFX_18555785_Chip-Seq_ESCs_Mouse1.49357502
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49254853
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48761611
56E2F1_18555785_Chip-Seq_ESCs_Mouse1.47254494
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.46569674
58IRF1_19129219_ChIP-ChIP_H3396_Human1.46377669
59PU1_27457419_Chip-Seq_LIVER_Mouse1.46198725
60EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.46071060
61DROSHA_22980978_ChIP-Seq_HELA_Human1.45724672
62P300_18555785_Chip-Seq_ESCs_Mouse1.45305793
63* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.45134504
64CMYC_18555785_Chip-Seq_ESCs_Mouse1.44458905
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44180788
66BCL6_27268052_Chip-Seq_Bcells_Human1.42709924
67KLF4_18555785_Chip-Seq_ESCs_Mouse1.41615041
68CTCF_18555785_Chip-Seq_ESCs_Mouse1.40606800
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.40185996
70SOX2_18555785_Chip-Seq_ESCs_Mouse1.39692668
71* CRX_20693478_ChIP-Seq_RETINA_Mouse1.39293126
72ERA_21632823_ChIP-Seq_H3396_Human1.38235630
73SMAD1_18555785_Chip-Seq_ESCs_Mouse1.35190396
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34379668
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34037398
76VDR_24763502_ChIP-Seq_THP-1_Human1.33985911
77CIITA_25753668_ChIP-Seq_RAJI_Human1.33746886
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32809588
79EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31685567
80* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30281207
81P68_20966046_ChIP-Seq_HELA_Human1.29107372
82TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28187161
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26357240
84RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.24687092
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24186864
86RUNX_20019798_ChIP-Seq_JUKART_Human1.23239931
87VDR_22108803_ChIP-Seq_LS180_Human1.22785455
88E2F1_20622854_ChIP-Seq_HELA_Human1.22489696
89BCOR_27268052_Chip-Seq_Bcells_Human1.20689471
90P300_27268052_Chip-Seq_Bcells_Human1.20631368
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18657441
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17936830
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.17086074
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16526478
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16526478
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16419621
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16186633
98* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14886651
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14311619
100PHF8_20622854_ChIP-Seq_HELA_Human1.12958370
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10835042
102SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10492612
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09260054
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09046958
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08578904
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08229954
107SMRT_27268052_Chip-Seq_Bcells_Human1.06365187
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05648270
109GATA1_22025678_ChIP-Seq_K562_Human1.05343291
110ELF1_20517297_ChIP-Seq_JURKAT_Human1.05180937
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04354056
112* STAT1_17558387_ChIP-Seq_HELA_Human1.03245545
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03078854
114MYB_26560356_Chip-Seq_TH1_Human1.02057894
115ER_23166858_ChIP-Seq_MCF-7_Human1.01774509
116* GATA1_19941827_ChIP-Seq_MEL_Mouse1.01126175
117RUNX1_22412390_ChIP-Seq_EML_Mouse1.00718353
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00174642
119TBL1_22424771_ChIP-Seq_293T_Human0.99657207
120OCT4_20526341_ChIP-Seq_ESCs_Human0.98999784
121* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98720490
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98703688
123KDM2B_26808549_Chip-Seq_REH_Human0.98492237
124OCT4_19829295_ChIP-Seq_ESCs_Human0.98193160
125GATA3_21878914_ChIP-Seq_MCF-7_Human0.97616437
126TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96917605
127WDR5_24793694_ChIP-Seq_LNCAP_Human0.96858186
128NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96588275
129* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96274629
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95080835
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.94809810
132GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93958946
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93952514
134KDM2B_26808549_Chip-Seq_DND41_Human0.93915553
135REST_21632747_ChIP-Seq_MESCs_Mouse0.93839119
136VDR_24787735_ChIP-Seq_THP-1_Human0.93717383
137RAC3_21632823_ChIP-Seq_H3396_Human0.92859757
138TAF2_19829295_ChIP-Seq_ESCs_Human0.92617087
139VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91498801
140TCF7_22412390_ChIP-Seq_EML_Mouse0.91233905
141STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89739063
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88984477
143NANOG_20526341_ChIP-Seq_ESCs_Human0.88892727
144GF1_26923725_Chip-Seq_HPCs_Mouse0.88797649
145YY1_22570637_ChIP-Seq_MALME-3M_Human0.88745032
146TP53_16413492_ChIP-PET_HCT116_Human0.88470356
147AR_21572438_ChIP-Seq_LNCaP_Human0.87947046
148NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87916079
149ESR1_21235772_ChIP-Seq_MCF-7_Human0.87613597
150* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87046694
151GATA6_21074721_ChIP-Seq_CACO-2_Human0.86827616
152TAL1_26923725_Chip-Seq_HPCs_Mouse0.86402102
153GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86369858
154MYB_26560356_Chip-Seq_TH2_Human0.86155623
155CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85536108
156HNFA_21074721_ChIP-Seq_CACO-2_Human0.85286014
157NFYA_21822215_ChIP-Seq_K562_Human0.84759220
158KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84695145
159P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.84295293
160GATA1_19941826_ChIP-Seq_K562_Human0.83668489
161P53_21459846_ChIP-Seq_SAOS-2_Human0.81826861
162BCAT_22108803_ChIP-Seq_LS180_Human0.81582826
163FOXA1_25329375_ChIP-Seq_VCAP_Human0.80876937
164FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80876937
165* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80144757
166PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79630579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.97449932
2MP0000569_abnormal_digit_pigmentation3.38851050
3MP0004381_abnormal_hair_follicle3.10209794
4MP0001835_abnormal_antigen_presentation2.94526676
5MP0005174_abnormal_tail_pigmentation2.69288451
6MP0006292_abnormal_olfactory_placode2.61384795
7MP0001800_abnormal_humoral_immune2.52394365
8MP0001790_abnormal_immune_system2.37795190
9MP0005387_immune_system_phenotype2.37795190
10MP0002277_abnormal_respiratory_mucosa2.36398611
11MP0005671_abnormal_response_to2.21419432
12MP0001188_hyperpigmentation2.20605424
13MP0002396_abnormal_hematopoietic_system2.09820714
14MP0002254_reproductive_system_inflammat2.05801861
15MP0002102_abnormal_ear_morphology2.04959479
16MP0000015_abnormal_ear_pigmentation1.93787656
17MP0002452_abnormal_antigen_presenting1.91988325
18MP0002723_abnormal_immune_serum1.90427948
19MP0003763_abnormal_thymus_physiology1.86242117
20MP0005670_abnormal_white_adipose1.84140475
21MP0004130_abnormal_muscle_cell1.82434816
22MP0003136_yellow_coat_color1.78433120
23MP0005365_abnormal_bile_salt1.76882938
24MP0008872_abnormal_physiological_respon1.75825550
25MP0005451_abnormal_body_composition1.73290577
26MP0005000_abnormal_immune_tolerance1.72086804
27MP0009764_decreased_sensitivity_to1.69800540
28MP0008995_early_reproductive_senescence1.68157289
29MP0008058_abnormal_DNA_repair1.65616682
30MP0003787_abnormal_imprinting1.62849411
31MP0005464_abnormal_platelet_physiology1.62455779
32MP0005025_abnormal_response_to1.62445226
33MP0003195_calcinosis1.61696936
34MP0002420_abnormal_adaptive_immunity1.61421148
35MP0002653_abnormal_ependyma_morphology1.61416119
36MP0002419_abnormal_innate_immunity1.61358339
37MP0001819_abnormal_immune_cell1.60745623
38MP0000566_synostosis1.60634549
39MP0003866_abnormal_defecation1.60369698
40MP0005645_abnormal_hypothalamus_physiol1.59532319
41MP0000685_abnormal_immune_system1.58187032
42MP0008057_abnormal_DNA_replication1.56492840
43MP0002163_abnormal_gland_morphology1.55595300
44MP0000383_abnormal_hair_follicle1.54871226
45MP0003646_muscle_fatigue1.53495298
46MP0005083_abnormal_biliary_tract1.49637865
47MP0004019_abnormal_vitamin_homeostasis1.49231012
48MP0002933_joint_inflammation1.48509192
49MP0005310_abnormal_salivary_gland1.48064803
50MP0001968_abnormal_touch/_nociception1.47896992
51MP0002876_abnormal_thyroid_physiology1.46194069
52MP0000579_abnormal_nail_morphology1.44543780
53MP0002928_abnormal_bile_duct1.41378166
54MP0002148_abnormal_hypersensitivity_rea1.39621730
55MP0000716_abnormal_immune_system1.39214719
56MP0001873_stomach_inflammation1.36930205
57MP0003436_decreased_susceptibility_to1.36738654
58MP0005075_abnormal_melanosome_morpholog1.35653275
59MP0000371_diluted_coat_color1.35130244
60MP0009785_altered_susceptibility_to1.34500175
61MP0008877_abnormal_DNA_methylation1.33521808
62MP0002398_abnormal_bone_marrow1.33388756
63MP0005423_abnormal_somatic_nervous1.31411200
64MP0004043_abnormal_pH_regulation1.31402472
65MP0004142_abnormal_muscle_tone1.27886611
66MP0003252_abnormal_bile_duct1.24327669
67MP0002638_abnormal_pupillary_reflex1.23950797
68MP0003183_abnormal_peptide_metabolism1.23627722
69MP0002095_abnormal_skin_pigmentation1.20386671
70MP0005360_urolithiasis1.18633977
71MP0010155_abnormal_intestine_physiology1.18350891
72MP0000689_abnormal_spleen_morphology1.17993482
73MP0002006_tumorigenesis1.17953198
74MP0005647_abnormal_sex_gland1.16400839
75MP0002138_abnormal_hepatobiliary_system1.14935096
76MP0003868_abnormal_feces_composition1.14854803
77MP0002166_altered_tumor_susceptibility1.14404103
78MP0001346_abnormal_lacrimal_gland1.11640409
79MP0008260_abnormal_autophagy1.11108019
80MP0003941_abnormal_skin_development1.10372251
81MP0005389_reproductive_system_phenotype1.10196299
82MP0000490_abnormal_crypts_of1.08931611
83MP0003045_fibrosis1.06534997
84MP0001485_abnormal_pinna_reflex1.04308889
85MP0001845_abnormal_inflammatory_respons1.03131963
86MP0002160_abnormal_reproductive_system1.03111650
87MP0002722_abnormal_immune_system1.02393535
88MP0005085_abnormal_gallbladder_physiolo1.02131558
89MP0004742_abnormal_vestibular_system1.00527412
90MP0003303_peritoneal_inflammation0.99386763
91MP0009745_abnormal_behavioral_response0.99223755
92MP0006082_CNS_inflammation0.98960849
93MP0005379_endocrine/exocrine_gland_phen0.98073207
94MP0002429_abnormal_blood_cell0.97936934
95MP0001501_abnormal_sleep_pattern0.97878662
96MP0003111_abnormal_nucleus_morphology0.97557173
97MP0001765_abnormal_ion_homeostasis0.96636437
98MP0009278_abnormal_bone_marrow0.95987250
99MP0003724_increased_susceptibility_to0.95351034
100MP0004808_abnormal_hematopoietic_stem0.94850030
101MP0000703_abnormal_thymus_morphology0.94543809
102MP0004947_skin_inflammation0.92872187
103MP0001663_abnormal_digestive_system0.91832108
104MP0005448_abnormal_energy_balance0.89437087
105MP0002075_abnormal_coat/hair_pigmentati0.89052371
106MP0005409_darkened_coat_color0.88889800
107MP0004145_abnormal_muscle_electrophysio0.87683529
108MP0001186_pigmentation_phenotype0.85951136
109MP0003172_abnormal_lysosome_physiology0.85883778
110MP0004885_abnormal_endolymph0.85371476
111MP0009046_muscle_twitch0.85357616
112MP0001502_abnormal_circadian_rhythm0.85277553
113MP0004134_abnormal_chest_morphology0.84925048
114MP0000631_abnormal_neuroendocrine_gland0.84624335
115MP0002064_seizures0.83416480
116MP0009333_abnormal_splenocyte_physiolog0.82974689
117MP0008961_abnormal_basal_metabolism0.80716672
118MP0002405_respiratory_system_inflammati0.80525587
119MP0002693_abnormal_pancreas_physiology0.79142876
120MP0008469_abnormal_protein_level0.78102101
121MP0001919_abnormal_reproductive_system0.77960922
122MP0001533_abnormal_skeleton_physiology0.77932449
123MP0005551_abnormal_eye_electrophysiolog0.77795159
124MP0005397_hematopoietic_system_phenotyp0.76621479
125MP0001545_abnormal_hematopoietic_system0.76621479
126MP0005257_abnormal_intraocular_pressure0.75634810
127MP0002272_abnormal_nervous_system0.75606798
128MP0002136_abnormal_kidney_physiology0.75076610
129MP0008875_abnormal_xenobiotic_pharmacok0.74504540
130MP0005646_abnormal_pituitary_gland0.74432184
131MP0002009_preneoplasia0.73143938
132MP0010678_abnormal_skin_adnexa0.73023407
133MP0001970_abnormal_pain_threshold0.72345428
134MP0010329_abnormal_lipoprotein_level0.72230626
135MP0000465_gastrointestinal_hemorrhage0.71475936
136MP0001119_abnormal_female_reproductive0.71165700
137MP0000470_abnormal_stomach_morphology0.70850596
138MP0003878_abnormal_ear_physiology0.70051960
139MP0005377_hearing/vestibular/ear_phenot0.70051960
140MP0000427_abnormal_hair_cycle0.68595076
141MP0002735_abnormal_chemical_nociception0.68391917

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.98200659
2Chromsome breakage (HP:0040012)5.29581691
3Genetic anticipation (HP:0003743)4.60498699
4Prostate neoplasm (HP:0100787)4.40974711
5Congenital stationary night blindness (HP:0007642)3.82557317
6Pancreatic cysts (HP:0001737)3.60119149
7Abnormality of the fingertips (HP:0001211)3.46369237
8Agammaglobulinemia (HP:0004432)3.36059471
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.26336317
10Recurrent cutaneous fungal infections (HP:0011370)3.24237934
11Chronic mucocutaneous candidiasis (HP:0002728)3.24237934
12Progressive cerebellar ataxia (HP:0002073)3.23863571
13Duplicated collecting system (HP:0000081)3.11318615
14IgG deficiency (HP:0004315)3.05425897
15Abnormality of DNA repair (HP:0003254)3.03147366
16Pendular nystagmus (HP:0012043)3.00833682
17Clubbing of toes (HP:0100760)3.00696776
18Pancreatic fibrosis (HP:0100732)2.88807689
19Abnormality of the renal collecting system (HP:0004742)2.86520278
20Abnormality of the prostate (HP:0008775)2.85209892
21Elevated erythrocyte sedimentation rate (HP:0003565)2.85150874
22Severe combined immunodeficiency (HP:0004430)2.79583421
23Panhypogammaglobulinemia (HP:0003139)2.79227188
24Molar tooth sign on MRI (HP:0002419)2.76706496
25Abnormality of midbrain morphology (HP:0002418)2.76706496
26Recurrent fungal infections (HP:0002841)2.75447423
27Colitis (HP:0002583)2.74525239
28True hermaphroditism (HP:0010459)2.73476685
29Lip pit (HP:0100267)2.72679418
30Recurrent sinusitis (HP:0011108)2.70068272
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.64215619
32Abolished electroretinogram (ERG) (HP:0000550)2.63204345
33Ectopic kidney (HP:0000086)2.60714005
34Inflammation of the large intestine (HP:0002037)2.58383177
35Cystic liver disease (HP:0006706)2.57776275
36Joint hemorrhage (HP:0005261)2.57344419
37Decreased central vision (HP:0007663)2.55297481
38Recurrent abscess formation (HP:0002722)2.54988281
39Recurrent bacterial skin infections (HP:0005406)2.52246824
40Hemiplegia (HP:0002301)2.51997104
41Stomach cancer (HP:0012126)2.49913199
42Abnormality of T cell number (HP:0011839)2.49688220
43Abnormality of the preputium (HP:0100587)2.48867605
44Clumsiness (HP:0002312)2.46293303
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.45851490
46Decreased circulating renin level (HP:0003351)2.43758121
47T lymphocytopenia (HP:0005403)2.43100033
48Abnormality of T cells (HP:0002843)2.42579913
49Nephronophthisis (HP:0000090)2.40958642
50Chronic diarrhea (HP:0002028)2.40831876
51Prolonged bleeding time (HP:0003010)2.40245199
52Abnormality of the renal cortex (HP:0011035)2.39351000
53Eczematoid dermatitis (HP:0000976)2.38771015
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.38511686
55Aplasia/Hypoplasia of the spleen (HP:0010451)2.36740958
56Impaired smooth pursuit (HP:0007772)2.36371648
57Absent/shortened dynein arms (HP:0200106)2.35763145
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.35763145
59Cheilitis (HP:0100825)2.35650719
60Acute lymphatic leukemia (HP:0006721)2.35465496
61Gaze-evoked nystagmus (HP:0000640)2.35273169
62Recurrent skin infections (HP:0001581)2.34957516
63Asplenia (HP:0001746)2.31524553
64IgM deficiency (HP:0002850)2.29479463
65Anal stenosis (HP:0002025)2.28117252
66Meckel diverticulum (HP:0002245)2.28113499
67Abnormality of chromosome stability (HP:0003220)2.27621990
68Recurrent viral infections (HP:0004429)2.27057386
69Febrile seizures (HP:0002373)2.25867915
70Attenuation of retinal blood vessels (HP:0007843)2.25866850
71Orchitis (HP:0100796)2.25505742
72Meningitis (HP:0001287)2.25486780
73Recurrent bronchitis (HP:0002837)2.25244126
74Abnormality of the ileum (HP:0001549)2.25139109
75Abnormality of binocular vision (HP:0011514)2.22850967
76Diplopia (HP:0000651)2.22850967
77Abnormality of T cell physiology (HP:0011840)2.21237078
78Gastrointestinal inflammation (HP:0004386)2.20771734
79Leukopenia (HP:0001882)2.19332777
80Gingival bleeding (HP:0000225)2.18805145
81Abnormality of B cell number (HP:0010975)2.18240584
82Abnormality of eosinophils (HP:0001879)2.16593957
83Vasculitis (HP:0002633)2.15471201
84Abnormality of the renal medulla (HP:0100957)2.15306535
85Gastrointestinal infarctions (HP:0005244)2.14257699
86Upper limb muscle weakness (HP:0003484)2.13654155
87Autoimmune thrombocytopenia (HP:0001973)2.12474312
88Abnormality of the carotid arteries (HP:0005344)2.12092731
89Mediastinal lymphadenopathy (HP:0100721)2.11324083
90Septo-optic dysplasia (HP:0100842)2.10933888
91Gingivitis (HP:0000230)2.09886117
92Hyperventilation (HP:0002883)2.07252336
93Pustule (HP:0200039)2.05569381
94Abnormal drinking behavior (HP:0030082)2.04703774
95Polydipsia (HP:0001959)2.04703774
96Hypochromic anemia (HP:0001931)2.04091122
97Severe visual impairment (HP:0001141)2.03756558
98Obstructive lung disease (HP:0006536)2.02469807
99Chronic obstructive pulmonary disease (HP:0006510)2.02469807
100Progressive inability to walk (HP:0002505)1.99056233
101Bony spicule pigmentary retinopathy (HP:0007737)1.99011465
102Tubular atrophy (HP:0000092)1.97925269
103Retrobulbar optic neuritis (HP:0100654)1.97097538
104Optic neuritis (HP:0100653)1.97097538
105Encephalitis (HP:0002383)1.96642171
106Ectropion (HP:0000656)1.96523626
107Furrowed tongue (HP:0000221)1.94779384
108Abnormality of ocular smooth pursuit (HP:0000617)1.93656431
109Inability to walk (HP:0002540)1.92979463
110Congenital sensorineural hearing impairment (HP:0008527)1.92917367
111Protruding tongue (HP:0010808)1.91884892
112Lymphopenia (HP:0001888)1.91710084
113Increased neuronal autofluorescent lipopigment (HP:0002074)1.90896839
114Visual hallucinations (HP:0002367)1.90497434
115Periodontitis (HP:0000704)1.90088561
116Reticulocytopenia (HP:0001896)1.88306528
117Aplasia/Hypoplasia of the patella (HP:0006498)1.85428558
118Epistaxis (HP:0000421)1.84914702
119Chronic hepatic failure (HP:0100626)1.84608757
120Hemoptysis (HP:0002105)1.84481789
121Autoimmune hemolytic anemia (HP:0001890)1.83246639
122Increased corneal curvature (HP:0100692)1.82477335
123Keratoconus (HP:0000563)1.82477335
124IgA deficiency (HP:0002720)1.82244255
125Gastrointestinal stroma tumor (HP:0100723)1.82044971
126Abnormality of the nasal septum (HP:0000419)1.80716328
127Abnormality of cells of the lymphoid lineage (HP:0012140)1.80395705
128Combined immunodeficiency (HP:0005387)1.80295180
129Concave nail (HP:0001598)1.80055870
130Myocardial infarction (HP:0001658)1.79546977
131Granulocytopenia (HP:0001913)1.78049766
132Tetany (HP:0001281)1.76826668
133Osteomalacia (HP:0002749)1.76475773
134Abnormality of male internal genitalia (HP:0000022)1.75939414
135Patellar aplasia (HP:0006443)1.75740254
136Eosinophilia (HP:0001880)1.74964791
137Leukocytosis (HP:0001974)1.74903323
138Hypoplasia of the thymus (HP:0000778)1.74574642
139Bile duct proliferation (HP:0001408)1.74002703
140Abnormal biliary tract physiology (HP:0012439)1.74002703
141Confusion (HP:0001289)1.73842596
142Tented upper lip vermilion (HP:0010804)1.73801237
143Oligodactyly (hands) (HP:0001180)1.71745613
144Abnormality of pyrimidine metabolism (HP:0004353)1.71593840
145Thyroiditis (HP:0100646)1.71155199
146Renal cortical cysts (HP:0000803)1.70919625
147Fair hair (HP:0002286)1.69317187
148Generalized hypopigmentation of hair (HP:0011358)1.68610398
149Abnormal rod and cone electroretinograms (HP:0008323)1.66664897
150Abnormality of the hepatic vasculature (HP:0006707)1.65064996
151Increased IgE level (HP:0003212)1.64761978
152Menorrhagia (HP:0000132)1.63184595
153Recurrent pneumonia (HP:0006532)1.62479613
154Anal atresia (HP:0002023)1.62465153
155Chronic otitis media (HP:0000389)1.61881315
156Stomatitis (HP:0010280)1.61630024
157Myelodysplasia (HP:0002863)1.60379605
158Anomalous pulmonary venous return (HP:0010772)1.59441352
159Pulmonary infiltrates (HP:0002113)1.58261838
160Myositis (HP:0100614)1.58162019
161Acute myeloid leukemia (HP:0004808)1.58134196
162Distal lower limb muscle weakness (HP:0009053)1.57766470
163Prolonged partial thromboplastin time (HP:0003645)1.56605116
164Abnormality of the intervertebral disk (HP:0005108)1.55977457
165Albinism (HP:0001022)1.54158914
166Elfin facies (HP:0004428)1.52947656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.10696843
2INSRR3.00409701
3MAP4K12.90206705
4TXK2.66031037
5TAOK32.31203974
6IRAK42.29244953
7CDK122.25879933
8MAP3K142.10190810
9GRK62.05649494
10MAP3K132.00931795
11EIF2AK21.99314590
12ACVR1B1.95487971
13LATS11.95148087
14BRD41.94179654
15BLK1.91420311
16JAK11.84980767
17FGFR41.83597135
18JAK31.81631796
19TNK21.80993414
20IKBKE1.79381095
21WNK41.78374642
22CAMK1D1.75570161
23CAMKK21.67484216
24TNIK1.65364580
25TYK21.63369702
26GRK11.61936683
27CAMKK11.61068214
28IKBKB1.60369480
29SIK21.59029164
30CAMK1G1.56236312
31TEC1.52413917
32BMPR1B1.52202640
33KIT1.48986951
34ZAK1.48113594
35IRAK11.43327355
36MAP2K61.39002516
37MST1R1.38420354
38NLK1.31193749
39DAPK21.24402848
40ADRBK21.21007825
41BTK1.17427236
42IRAK21.17132774
43CASK1.13545970
44CDK31.12900093
45TGFBR21.12681502
46CHUK1.10012281
47HCK1.09995383
48PRKCQ1.07914772
49PKN11.07899113
50RIPK41.07299614
51PRKD21.06959508
52YES11.02479274
53PRKCH1.01621608
54NTRK20.93892558
55TRIB30.92716864
56STK380.91677296
57MAP3K60.91376732
58PRKAA20.90706603
59FGFR30.90329230
60EPHA30.89421913
61SYK0.88771856
62NEK60.88469244
63CSF1R0.87280482
64MAP2K30.86935914
65MARK20.86798362
66MAPK130.85252846
67RPS6KA60.84242034
68LYN0.82408601
69PIK3CG0.82215037
70PTK2B0.81322451
71PASK0.81011894
72MARK30.80807585
73MAP3K110.78840849
74SRPK10.78349546
75CDK90.77808224
76PINK10.77706617
77ITK0.76175378
78LCK0.75039781
79SGK20.74238951
80ADRBK10.73702677
81PRPF4B0.72504703
82MAP4K20.72216219
83WNK10.71916760
84FES0.71628983
85STK110.71618033
86DYRK30.71578126
87TYRO30.71432987
88ZAP700.71237631
89FGFR20.71236900
90CDC42BPA0.70874032
91TLK10.70416122
92MAP2K20.69393903
93HIPK20.69194402
94MARK10.69105911
95PDK10.69065863
96MAPKAPK30.66501456
97CAMK10.65509059
98ATR0.64042892
99MAPK70.63960295
100MAPK120.63060746
101CSK0.62534761
102MAP3K70.61266277
103FRK0.61058883
104MKNK20.60952384
105MAPK110.60242193
106JAK20.60171170
107MELK0.59249092
108STK38L0.58956676
109TBK10.58830310
110NUAK10.58547227
111PIM10.57907930
112EPHB10.57769658
113SIK10.56392234
114PLK40.56364839
115STK40.55858645
116RPS6KA50.54140751
117OXSR10.51913522
118CLK10.51727759
119SGK30.51365844
120ABL10.48762846
121SGK10.48670990
122SGK2230.47681781
123SGK4940.47681781
124RPS6KC10.46240353
125RPS6KL10.46240353
126CAMK40.45684383
127ERBB20.44015545
128CDK70.43929300
129PRKAA10.40552236
130TRPM70.39857504
131PRKCI0.38408554
132PDGFRB0.37847043
133PIK3CA0.36713743
134GRK70.36176578
135MAPKAPK50.36077849
136MAP3K10.35808215
137BMX0.35801887
138NEK20.35719315
139FLT30.35110114
140MAPK150.34783003
141EPHA20.34312417
142CHEK20.34300291
143MAPK30.32097283

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.82054982
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.53750815
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.32676446
4Fanconi anemia pathway_Homo sapiens_hsa034602.27094534
5ABC transporters_Homo sapiens_hsa020102.13422545
6Lysine degradation_Homo sapiens_hsa003102.06736948
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.01904244
8Hematopoietic cell lineage_Homo sapiens_hsa046401.94958219
9Vitamin digestion and absorption_Homo sapiens_hsa049771.84088615
10Other glycan degradation_Homo sapiens_hsa005111.80715509
11B cell receptor signaling pathway_Homo sapiens_hsa046621.79168811
12Type I diabetes mellitus_Homo sapiens_hsa049401.75150225
13Staphylococcus aureus infection_Homo sapiens_hsa051501.71325822
14Phototransduction_Homo sapiens_hsa047441.64997298
15Measles_Homo sapiens_hsa051621.58906151
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.58376056
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56530614
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51169143
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50516605
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44525449
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.41081847
22Osteoclast differentiation_Homo sapiens_hsa043801.36464483
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34323289
24Graft-versus-host disease_Homo sapiens_hsa053321.33437629
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29090601
26Nitrogen metabolism_Homo sapiens_hsa009101.29082933
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28342625
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.27622588
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.24948333
30Herpes simplex infection_Homo sapiens_hsa051681.24816250
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22198353
32beta-Alanine metabolism_Homo sapiens_hsa004101.21850103
33Sphingolipid metabolism_Homo sapiens_hsa006001.20787720
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19655088
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19620618
36Leishmaniasis_Homo sapiens_hsa051401.17600043
37Antigen processing and presentation_Homo sapiens_hsa046121.09788867
38Retinol metabolism_Homo sapiens_hsa008301.08508183
39Complement and coagulation cascades_Homo sapiens_hsa046101.06462773
40T cell receptor signaling pathway_Homo sapiens_hsa046601.06316792
41Nicotine addiction_Homo sapiens_hsa050331.06049872
42Influenza A_Homo sapiens_hsa051641.03600809
43Allograft rejection_Homo sapiens_hsa053301.03263873
44Chemokine signaling pathway_Homo sapiens_hsa040620.99020197
45Histidine metabolism_Homo sapiens_hsa003400.98146170
46Glycerolipid metabolism_Homo sapiens_hsa005610.97762880
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96430091
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96291886
49Sulfur relay system_Homo sapiens_hsa041220.95989924
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94781549
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94029757
52Notch signaling pathway_Homo sapiens_hsa043300.93677496
53TNF signaling pathway_Homo sapiens_hsa046680.92571792
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91752612
55Homologous recombination_Homo sapiens_hsa034400.91137305
56Tryptophan metabolism_Homo sapiens_hsa003800.88354417
57Linoleic acid metabolism_Homo sapiens_hsa005910.86510988
58Inositol phosphate metabolism_Homo sapiens_hsa005620.85932050
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.85629692
60Acute myeloid leukemia_Homo sapiens_hsa052210.83177771
61Autoimmune thyroid disease_Homo sapiens_hsa053200.81463409
62Systemic lupus erythematosus_Homo sapiens_hsa053220.81020189
63Asthma_Homo sapiens_hsa053100.78587146
64Non-homologous end-joining_Homo sapiens_hsa034500.77211403
65Prolactin signaling pathway_Homo sapiens_hsa049170.76737765
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76587276
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76483093
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75614602
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74651037
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74422428
71Type II diabetes mellitus_Homo sapiens_hsa049300.72669997
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71777231
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70963869
74MAPK signaling pathway_Homo sapiens_hsa040100.70935890
75Taste transduction_Homo sapiens_hsa047420.70827757
76Calcium signaling pathway_Homo sapiens_hsa040200.70235797
77Selenocompound metabolism_Homo sapiens_hsa004500.67720916
78Toxoplasmosis_Homo sapiens_hsa051450.67427262
79Cholinergic synapse_Homo sapiens_hsa047250.66955653
80Arachidonic acid metabolism_Homo sapiens_hsa005900.65316137
81Hepatitis C_Homo sapiens_hsa051600.65035878
82Malaria_Homo sapiens_hsa051440.64871035
83Regulation of autophagy_Homo sapiens_hsa041400.64451995
84African trypanosomiasis_Homo sapiens_hsa051430.63977504
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62450906
86Tuberculosis_Homo sapiens_hsa051520.59657364
87Dorso-ventral axis formation_Homo sapiens_hsa043200.58536403
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56480187
89Circadian entrainment_Homo sapiens_hsa047130.55261560
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54753018
91Olfactory transduction_Homo sapiens_hsa047400.54274023
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54139227
93Insulin secretion_Homo sapiens_hsa049110.53608365
94Glutamatergic synapse_Homo sapiens_hsa047240.53472679
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53059493
96Chemical carcinogenesis_Homo sapiens_hsa052040.52410228
97Choline metabolism in cancer_Homo sapiens_hsa052310.52378204
98Small cell lung cancer_Homo sapiens_hsa052220.51839382
99Caffeine metabolism_Homo sapiens_hsa002320.51791062
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.50925326
101Serotonergic synapse_Homo sapiens_hsa047260.50818312
102MicroRNAs in cancer_Homo sapiens_hsa052060.50060428
103Hepatitis B_Homo sapiens_hsa051610.49449577
104VEGF signaling pathway_Homo sapiens_hsa043700.49143068
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.49059796
106Salivary secretion_Homo sapiens_hsa049700.47798275
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.47152691
108Apoptosis_Homo sapiens_hsa042100.47068212
109Ovarian steroidogenesis_Homo sapiens_hsa049130.46516442
110FoxO signaling pathway_Homo sapiens_hsa040680.46303672
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46099870
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44234719
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.43279601
114Chronic myeloid leukemia_Homo sapiens_hsa052200.42654432
115Ras signaling pathway_Homo sapiens_hsa040140.41968308
116Viral myocarditis_Homo sapiens_hsa054160.41955539
117Ether lipid metabolism_Homo sapiens_hsa005650.41651228
118mTOR signaling pathway_Homo sapiens_hsa041500.41590647
119Pancreatic cancer_Homo sapiens_hsa052120.41183899
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40862169
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40613291
122Morphine addiction_Homo sapiens_hsa050320.40368533
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.40344673
124p53 signaling pathway_Homo sapiens_hsa041150.40099690
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39835910
126Non-small cell lung cancer_Homo sapiens_hsa052230.39808993
127Peroxisome_Homo sapiens_hsa041460.39752955
128Insulin resistance_Homo sapiens_hsa049310.39404327
129Rheumatoid arthritis_Homo sapiens_hsa053230.38576192
130One carbon pool by folate_Homo sapiens_hsa006700.36934213
131Platelet activation_Homo sapiens_hsa046110.35139081

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