SF3B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.56425867
2nuclear pore complex assembly (GO:0051292)4.86970535
3nuclear pore organization (GO:0006999)4.41498307
4phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.29482584
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.05641143
6positive regulation of gamma-delta T cell activation (GO:0046645)4.03342293
7negative regulation of histone methylation (GO:0031061)3.99245602
8positive regulation of granulocyte differentiation (GO:0030854)3.74655839
9pore complex assembly (GO:0046931)3.70408051
10regulation of RNA export from nucleus (GO:0046831)3.67276081
11pre-miRNA processing (GO:0031054)3.64794627
12regulation of histone H3-K9 methylation (GO:0051570)3.60794237
13response to interleukin-15 (GO:0070672)3.58973665
14negative regulation of DNA repair (GO:0045738)3.58946345
15mitotic chromosome condensation (GO:0007076)3.54503330
16alternative mRNA splicing, via spliceosome (GO:0000380)3.51661911
17DNA topological change (GO:0006265)3.48845755
18DNA unwinding involved in DNA replication (GO:0006268)3.43180326
19kinetochore organization (GO:0051383)3.39256377
20histone H3-K4 trimethylation (GO:0080182)3.30384960
21regulation of DNA endoreduplication (GO:0032875)3.28721526
22regulation of B cell differentiation (GO:0045577)3.26888326
23dosage compensation (GO:0007549)3.26732406
24DNA strand renaturation (GO:0000733)3.25553860
25regulation of gamma-delta T cell differentiation (GO:0045586)3.24942007
26DNA duplex unwinding (GO:0032508)3.21874608
27DNA geometric change (GO:0032392)3.21550277
28mRNA splice site selection (GO:0006376)3.17307051
29negative T cell selection (GO:0043383)3.16670462
30negative regulation of cell killing (GO:0031342)3.13258504
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13258504
32histone H4-K16 acetylation (GO:0043984)3.12663436
33histone demethylation (GO:0016577)3.11888437
34positive regulation of B cell differentiation (GO:0045579)3.11677832
35regulation of histone H3-K27 methylation (GO:0061085)3.10478236
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07404472
37sister chromatid segregation (GO:0000819)3.06949579
38sister chromatid cohesion (GO:0007062)3.06807790
39monoubiquitinated protein deubiquitination (GO:0035520)3.06505583
40negative regulation of T cell mediated immunity (GO:0002710)3.06176490
41mitotic nuclear envelope disassembly (GO:0007077)3.05151259
42negative thymic T cell selection (GO:0045060)3.03276615
43regulation of gamma-delta T cell activation (GO:0046643)3.02494568
44positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.00499015
45negative regulation of RNA splicing (GO:0033119)2.96494235
46membrane disassembly (GO:0030397)2.94940031
47nuclear envelope disassembly (GO:0051081)2.94940031
48protein localization to kinetochore (GO:0034501)2.94837568
49hepatocyte apoptotic process (GO:0097284)2.92541240
50regulation of nucleobase-containing compound transport (GO:0032239)2.92209253
51regulation of alpha-beta T cell proliferation (GO:0046640)2.92062331
52positive regulation of histone H3-K4 methylation (GO:0051571)2.91644463
53peptidyl-lysine trimethylation (GO:0018023)2.91262165
54cellular response to interleukin-15 (GO:0071350)2.90819097
55thymic T cell selection (GO:0045061)2.90484715
56regulation of sister chromatid cohesion (GO:0007063)2.88972367
57activated T cell proliferation (GO:0050798)2.87657752
58cellular extravasation (GO:0045123)2.87147682
59T cell migration (GO:0072678)2.85939288
60definitive hemopoiesis (GO:0060216)2.84811653
61translesion synthesis (GO:0019985)2.84603012
62histone H3-K4 methylation (GO:0051568)2.81281819
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80595840
64negative regulation of fibroblast apoptotic process (GO:2000270)2.79487109
65histone H3-K36 demethylation (GO:0070544)2.78701209
66positive T cell selection (GO:0043368)2.78547433
67positive regulation of alpha-beta T cell proliferation (GO:0046641)2.77332523
68positive thymic T cell selection (GO:0045059)2.77148336
69negative regulation of lymphocyte mediated immunity (GO:0002707)2.76698292
70negative regulation of histone modification (GO:0031057)2.76366311
71embryonic process involved in female pregnancy (GO:0060136)2.76240918
72protein demethylation (GO:0006482)2.76051480
73protein dealkylation (GO:0008214)2.76051480
74regulation of spindle organization (GO:0090224)2.74928907
75B cell receptor signaling pathway (GO:0050853)2.74642572
76cellular hyperosmotic response (GO:0071474)2.72863042
77regulation of histone methylation (GO:0031060)2.71886038
78histone deubiquitination (GO:0016578)2.70807055
79DNA replication-independent nucleosome assembly (GO:0006336)2.70548736
80DNA replication-independent nucleosome organization (GO:0034724)2.70548736
81histone H3-K9 methylation (GO:0051567)2.69609820
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.69099140
83regulation of centriole replication (GO:0046599)2.68772185
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66835621
85negative regulation of chromatin modification (GO:1903309)2.66834971
86positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.66685259
87positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66685259
88positive regulation of mitotic sister chromatid separation (GO:1901970)2.66685259
89V(D)J recombination (GO:0033151)2.66432256
90interferon-gamma production (GO:0032609)2.66247930
91DNA conformation change (GO:0071103)2.65527213
92meiotic chromosome segregation (GO:0045132)2.65240078
93regulation of histone H3-K4 methylation (GO:0051569)2.64297177
94histone mRNA catabolic process (GO:0071044)2.63168059
95negative regulation of mRNA processing (GO:0050686)2.62557263
96cytoplasmic mRNA processing body assembly (GO:0033962)2.59942319
97regulation of fibroblast apoptotic process (GO:2000269)2.58286647
98histone H3-K9 demethylation (GO:0033169)2.58260406
99negative regulation of B cell proliferation (GO:0030889)2.57969646
100antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.57733664
101antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.57733664
102regulation of B cell receptor signaling pathway (GO:0050855)2.56133194
103kinetochore assembly (GO:0051382)2.55883338
104protein localization to chromosome, centromeric region (GO:0071459)2.55745553
105mitotic recombination (GO:0006312)2.55548266
106chromatin assembly or disassembly (GO:0006333)2.54678790
107histone H2A acetylation (GO:0043968)2.54638845
108T cell selection (GO:0045058)2.52940915
109neural tube formation (GO:0001841)2.52896885
110positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50502181
111cellular response to ethanol (GO:0071361)2.50326757
112regulation of mitotic spindle organization (GO:0060236)2.49187710
113interkinetic nuclear migration (GO:0022027)2.49105020
114positive regulation of chromosome segregation (GO:0051984)2.48945238
115regulation of interleukin-12 biosynthetic process (GO:0045075)2.48473077
116antigen processing and presentation of endogenous antigen (GO:0019883)2.48317298
117positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.47835980
118B cell proliferation (GO:0042100)2.46651071
119nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.46596781
120negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.46231434
121detection of other organism (GO:0098543)2.46108242
122histone lysine methylation (GO:0034968)2.45652725
123centrosome localization (GO:0051642)2.45558884
124regulation of granulocyte differentiation (GO:0030852)2.44925011
125positive regulation of histone methylation (GO:0031062)2.44670776
126mRNA export from nucleus (GO:0006406)2.44212755
127postreplication repair (GO:0006301)2.43624235
128ATP-dependent chromatin remodeling (GO:0043044)2.43268854
129nucleus organization (GO:0006997)2.43100323
130negative regulation of translation, ncRNA-mediated (GO:0040033)2.42362183
131regulation of translation, ncRNA-mediated (GO:0045974)2.42362183
132negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42362183
133RNA export from nucleus (GO:0006405)2.41701031
134mitotic sister chromatid segregation (GO:0000070)2.40191685
135peptidyl-lysine methylation (GO:0018022)2.39836998
136mRNA transport (GO:0051028)2.39833350
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.39713291
138histone H3-K9 modification (GO:0061647)2.39648565
139positive regulation of DNA-templated transcription, initiation (GO:2000144)2.39382275
140negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.39079863
141negative regulation of T-helper cell differentiation (GO:0045623)2.39079863
142regulation of DNA damage checkpoint (GO:2000001)2.38909161
143CENP-A containing nucleosome assembly (GO:0034080)2.38841347
144histone lysine demethylation (GO:0070076)2.38550674
145nuclear envelope organization (GO:0006998)2.38265036
146poly(A)+ mRNA export from nucleus (GO:0016973)2.37810091
147regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.37273886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.96752398
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.09623290
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.22301339
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.13720323
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95981838
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.08601534
7MYC_22102868_ChIP-Seq_BL_Human3.00428954
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.87608713
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.86997239
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81460373
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64496861
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52609723
13* E2F1_21310950_ChIP-Seq_MCF-7_Human2.11974317
14* CIITA_25753668_ChIP-Seq_RAJI_Human2.10493652
15* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07484780
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.03444888
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03316737
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02376608
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02129111
20MYB_26560356_Chip-Seq_TH2_Human1.94453937
21* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85965070
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81599168
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78228059
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76831849
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75396218
26RUNX_20019798_ChIP-Seq_JUKART_Human1.73729552
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73283835
28MYB_26560356_Chip-Seq_TH1_Human1.72119137
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.66536355
30SCL_19346495_ChIP-Seq_HPC-7_Human1.63567529
31VDR_21846776_ChIP-Seq_THP-1_Human1.59116541
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.59051070
33* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58987514
34* ELK1_19687146_ChIP-ChIP_HELA_Human1.58427817
35TCF7_22412390_ChIP-Seq_EML_Mouse1.54362295
36UTX_26944678_Chip-Seq_JUKART_Human1.53721838
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51973689
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.51377738
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50372070
40* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47803494
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.44851931
42* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44459183
43AR_21909140_ChIP-Seq_LNCAP_Human1.43788165
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43414080
45VDR_23849224_ChIP-Seq_CD4+_Human1.42586700
46MAF_26560356_Chip-Seq_TH1_Human1.40905170
47FUS_26573619_Chip-Seq_HEK293_Human1.38248455
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37184462
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35901795
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35824167
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35527634
52* SPI1_23547873_ChIP-Seq_NB4_Human1.35264965
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34981121
54* FLI1_27457419_Chip-Seq_LIVER_Mouse1.34822323
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34566910
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33351099
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.33089617
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32055369
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31993193
60KDM5A_27292631_Chip-Seq_BREAST_Human1.28059722
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27669315
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25326242
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24933922
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.23598997
65FOXP3_21729870_ChIP-Seq_TREG_Human1.23215294
66GATA1_22025678_ChIP-Seq_K562_Human1.23073680
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22842350
68* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21279021
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21231040
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20229068
71* RUNX1_22412390_ChIP-Seq_EML_Mouse1.16769148
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15029689
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14593913
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13401410
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13157278
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12840403
77* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12794145
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11271134
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10737746
80VDR_24763502_ChIP-Seq_THP-1_Human1.09076087
81GATA3_27048872_Chip-Seq_THYMUS_Human1.09063289
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07104700
83* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07100837
84* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06874565
85* RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06154975
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05952457
87* GATA3_26560356_Chip-Seq_TH2_Human1.05131384
88* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05115223
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.03990038
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03435969
91* EZH2_27294783_Chip-Seq_NPCs_Mouse1.02612571
92SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02601829
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01293752
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00060547
95* TFEB_21752829_ChIP-Seq_HELA_Human0.99590109
96* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98284205
97TAF15_26573619_Chip-Seq_HEK293_Human0.97777435
98KDM2B_26808549_Chip-Seq_DND41_Human0.97532583
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96883475
100* XRN2_22483619_ChIP-Seq_HELA_Human0.96704899
101SALL4_22934838_ChIP-ChIP_CD34+_Human0.96186152
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95202654
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94643833
104* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93832312
105IGF1R_20145208_ChIP-Seq_DFB_Human0.93736847
106* IRF8_27001747_Chip-Seq_BMDM_Mouse0.93132632
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92947020
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92926901
109VDR_24787735_ChIP-Seq_THP-1_Human0.92720303
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92326652
111EWS_26573619_Chip-Seq_HEK293_Human0.92091658
112FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91155184
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91146399
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90751711
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89872036
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89859247
117POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89600069
118* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89519111
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88373446
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88216579
121IRF8_21731497_ChIP-ChIP_J774_Mouse0.87404804
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86754678
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86358646
124* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85331268
125* NFE2_27457419_Chip-Seq_LIVER_Mouse0.84531676
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84281140
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84225890
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.83794331
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.83280457
130MAF_26560356_Chip-Seq_TH2_Human0.83192207
131* PU_27001747_Chip-Seq_BMDM_Mouse0.82577679
132SPI1_23127762_ChIP-Seq_K562_Human0.81695129
133CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81094275
134* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78446802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.33513487
2MP0010094_abnormal_chromosome_stability3.18759180
3MP0008057_abnormal_DNA_replication2.95665332
4MP0002396_abnormal_hematopoietic_system2.84529134
5MP0003763_abnormal_thymus_physiology2.72016468
6MP0003111_abnormal_nucleus_morphology2.62139634
7MP0003077_abnormal_cell_cycle2.60786830
8MP0004808_abnormal_hematopoietic_stem2.46968429
9MP0003693_abnormal_embryo_hatching2.44914409
10MP0003787_abnormal_imprinting2.43289095
11MP0008007_abnormal_cellular_replicative2.26860300
12MP0002166_altered_tumor_susceptibility2.25939399
13MP0003221_abnormal_cardiomyocyte_apopto2.13569126
14MP0008058_abnormal_DNA_repair2.07171755
15MP0008877_abnormal_DNA_methylation2.05024266
16MP0000703_abnormal_thymus_morphology2.02307343
17MP0010307_abnormal_tumor_latency2.00255964
18MP0010352_gastrointestinal_tract_polyps1.98321225
19MP0004957_abnormal_blastocyst_morpholog1.96896763
20MP0005671_abnormal_response_to1.95123074
21MP0001835_abnormal_antigen_presentation1.95040207
22MP0002398_abnormal_bone_marrow1.94985541
23MP0006054_spinal_hemorrhage1.94568668
24MP0003121_genomic_imprinting1.93499267
25MP0010234_abnormal_vibrissa_follicle1.90740687
26MP0002009_preneoplasia1.88567240
27MP0001800_abnormal_humoral_immune1.85589917
28MP0002006_tumorigenesis1.83348982
29MP0000685_abnormal_immune_system1.81666064
30MP0003724_increased_susceptibility_to1.77107397
31MP0008260_abnormal_autophagy1.72702801
32MP0003436_decreased_susceptibility_to1.69046286
33MP0005076_abnormal_cell_differentiation1.67483385
34MP0004264_abnormal_extraembryonic_tissu1.66192069
35MP0000350_abnormal_cell_proliferation1.62509949
36MP0002420_abnormal_adaptive_immunity1.57129420
37MP0001819_abnormal_immune_cell1.53469724
38MP0002452_abnormal_antigen_presenting1.52986890
39MP0002722_abnormal_immune_system1.52679999
40MP0000689_abnormal_spleen_morphology1.49177531
41MP0001873_stomach_inflammation1.48799909
42MP0003300_gastrointestinal_ulcer1.47799423
43MP0000716_abnormal_immune_system1.47461548
44MP0001730_embryonic_growth_arrest1.44369769
45MP0009278_abnormal_bone_marrow1.42868079
46MP0003656_abnormal_erythrocyte_physiolo1.40975540
47MP0003123_paternal_imprinting1.40054271
48MP0001790_abnormal_immune_system1.36806049
49MP0005387_immune_system_phenotype1.36806049
50MP0005397_hematopoietic_system_phenotyp1.34192044
51MP0001545_abnormal_hematopoietic_system1.34192044
52MP0002723_abnormal_immune_serum1.32914578
53MP0004381_abnormal_hair_follicle1.32073599
54MP0001853_heart_inflammation1.30666142
55MP0000465_gastrointestinal_hemorrhage1.30430879
56MP0003172_abnormal_lysosome_physiology1.29184787
57MP0002429_abnormal_blood_cell1.29084566
58MP0003828_pulmonary_edema1.27555486
59MP0005075_abnormal_melanosome_morpholog1.26688941
60MP0002095_abnormal_skin_pigmentation1.26643575
61MP0005174_abnormal_tail_pigmentation1.24911366
62MP0000490_abnormal_crypts_of1.18394463
63MP0002084_abnormal_developmental_patter1.17606745
64MP0001672_abnormal_embryogenesis/_devel1.17074343
65MP0005380_embryogenesis_phenotype1.17074343
66MP0005000_abnormal_immune_tolerance1.16544108
67MP0004197_abnormal_fetal_growth/weight/1.15583793
68MP0003890_abnormal_embryonic-extraembry1.13229458
69MP0002086_abnormal_extraembryonic_tissu1.12698413
70MP0002088_abnormal_embryonic_growth/wei1.10959508
71MP0005310_abnormal_salivary_gland1.09991803
72MP0003984_embryonic_growth_retardation1.09657898
73MP0001697_abnormal_embryo_size1.08438867
74MP0004883_abnormal_blood_vessel1.05830145
75MP0002019_abnormal_tumor_incidence1.04935778
76MP0002085_abnormal_embryonic_tissue1.04505084
77MP0010155_abnormal_intestine_physiology1.04300220
78MP0008932_abnormal_embryonic_tissue0.99901704
79MP0005025_abnormal_response_to0.99855621
80MP0002405_respiratory_system_inflammati0.99523421
81* MP0002080_prenatal_lethality0.98525827
82MP0003786_premature_aging0.98049185
83MP0003866_abnormal_defecation0.97503423
84MP0010678_abnormal_skin_adnexa0.96977676
85MP0000313_abnormal_cell_death0.96589980
86MP0009333_abnormal_splenocyte_physiolog0.96324954
87MP0001851_eye_inflammation0.95358793
88MP0003183_abnormal_peptide_metabolism0.95149759
89MP0002877_abnormal_melanocyte_morpholog0.94296502
90MP0003303_peritoneal_inflammation0.93971436
91MP0009703_decreased_birth_body0.93726920
92MP0008995_early_reproductive_senescence0.93185387
93MP0001293_anophthalmia0.91210157
94MP0004185_abnormal_adipocyte_glucose0.90436634
95MP0004947_skin_inflammation0.90080556
96MP0000733_abnormal_muscle_development0.89546658
97MP0003567_abnormal_fetal_cardiomyocyte0.87755492
98MP0002075_abnormal_coat/hair_pigmentati0.86314440
99MP0002933_joint_inflammation0.85093588
100MP0000371_diluted_coat_color0.84508377
101MP0000383_abnormal_hair_follicle0.83688155
102MP0000015_abnormal_ear_pigmentation0.81364963
103MP0003943_abnormal_hepatobiliary_system0.80996775
104MP0003935_abnormal_craniofacial_develop0.80519228
105MP0003115_abnormal_respiratory_system0.79342533
106MP0009672_abnormal_birth_weight0.77860485
107MP0008961_abnormal_basal_metabolism0.77543225
108MP0002925_abnormal_cardiovascular_devel0.77123861
109MP0001177_atelectasis0.74859551
110MP0005621_abnormal_cell_physiology0.74810435
111MP0000537_abnormal_urethra_morphology0.74700594
112MP0003566_abnormal_cell_adhesion0.73964998
113MP0002092_abnormal_eye_morphology0.73742489
114MP0005388_respiratory_system_phenotype0.71705288
115MP0002133_abnormal_respiratory_system0.71705288
116MP0001915_intracranial_hemorrhage0.71039630
117MP0002928_abnormal_bile_duct0.70892657
118MP0003448_altered_tumor_morphology0.70735997
119MP0003091_abnormal_cell_migration0.68299680
120MP0002419_abnormal_innate_immunity0.67478297
121MP0001186_pigmentation_phenotype0.67058498
122MP0000428_abnormal_craniofacial_morphol0.66383642
123MP0005384_cellular_phenotype0.66123617
124MP0005248_abnormal_Harderian_gland0.65980427

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.71855468
2Volvulus (HP:0002580)3.66033483
3Abnormality of the fingertips (HP:0001211)3.58782650
4Eczematoid dermatitis (HP:0000976)3.06134547
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.97930065
6Short 4th metacarpal (HP:0010044)2.97930065
7T lymphocytopenia (HP:0005403)2.84204980
8Colitis (HP:0002583)2.81252753
9Recurrent cutaneous fungal infections (HP:0011370)2.79382687
10Chronic mucocutaneous candidiasis (HP:0002728)2.79382687
11Recurrent bacterial skin infections (HP:0005406)2.78922486
12Hepatoblastoma (HP:0002884)2.59532022
13IgM deficiency (HP:0002850)2.58378374
14Abnormality of T cell number (HP:0011839)2.58205763
15Nephroblastoma (Wilms tumor) (HP:0002667)2.56756893
16Optic neuritis (HP:0100653)2.52803323
17Retrobulbar optic neuritis (HP:0100654)2.52803323
18Recurrent abscess formation (HP:0002722)2.46982895
19Recurrent viral infections (HP:0004429)2.46608956
20Absent frontal sinuses (HP:0002688)2.46304115
21Prominent nose (HP:0000448)2.44639147
22Embryonal renal neoplasm (HP:0011794)2.42528944
23Macroorchidism (HP:0000053)2.39948340
24Thyroiditis (HP:0100646)2.39283932
25Thyroid carcinoma (HP:0002890)2.35046308
26Gastrointestinal infarctions (HP:0005244)2.34024736
27Asymmetry of the thorax (HP:0001555)2.32572175
28Encephalitis (HP:0002383)2.30613539
29Lymphopenia (HP:0001888)2.29771827
30Ectopic kidney (HP:0000086)2.26793982
31Chromsome breakage (HP:0040012)2.25989241
32Colon cancer (HP:0003003)2.24390040
33Medulloblastoma (HP:0002885)2.24321798
34Myositis (HP:0100614)2.23121760
35Recurrent bronchitis (HP:0002837)2.22386540
36Panhypogammaglobulinemia (HP:0003139)2.20246319
37Abnormality of T cells (HP:0002843)2.20202820
38Transitional cell carcinoma of the bladder (HP:0006740)2.19343741
39Abnormality of cells of the lymphoid lineage (HP:0012140)2.18403228
40High pitched voice (HP:0001620)2.17768199
41Keratoconjunctivitis sicca (HP:0001097)2.17249817
42Long eyelashes (HP:0000527)2.16378212
43Basal cell carcinoma (HP:0002671)2.16294219
44Recurrent skin infections (HP:0001581)2.15879419
45Inflammation of the large intestine (HP:0002037)2.15814536
46Abnormal hair whorl (HP:0010721)2.15420820
47Ependymoma (HP:0002888)2.14942625
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14270508
49Meningitis (HP:0001287)2.14211432
50Abnormality of chromosome stability (HP:0003220)2.13955502
51Abnormality of B cell number (HP:0010975)2.13813836
52B lymphocytopenia (HP:0010976)2.13813836
53Orchitis (HP:0100796)2.11779003
54Increased nuchal translucency (HP:0010880)2.10889558
55Agnosia (HP:0010524)2.09776376
56Curly hair (HP:0002212)2.08312066
57Gastrointestinal inflammation (HP:0004386)2.07098405
58Acute myeloid leukemia (HP:0004808)2.05771490
59Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.04611073
60Anal stenosis (HP:0002025)2.04453046
61Chest pain (HP:0100749)2.04194356
62Narrow palate (HP:0000189)2.02793182
63Proximal placement of thumb (HP:0009623)2.01112677
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01086793
65Bladder carcinoma (HP:0002862)2.00301438
66Bladder neoplasm (HP:0009725)2.00301438
67Cystic hygroma (HP:0000476)1.98192003
68Hypoplasia of the thymus (HP:0000778)1.97859765
69Syringomyelia (HP:0003396)1.96666134
70Spinal cord lesions (HP:0100561)1.96666134
71Deviation of the thumb (HP:0009603)1.96098186
72IgG deficiency (HP:0004315)1.95351272
73Large earlobe (HP:0009748)1.94299992
74Broad alveolar ridges (HP:0000187)1.94221782
75Agammaglobulinemia (HP:0004432)1.93779896
76Abnormality of eosinophils (HP:0001879)1.93430650
77Lymphoma (HP:0002665)1.93147159
78Eosinophilia (HP:0001880)1.92492220
79Neoplasm of the tracheobronchial system (HP:0100552)1.92275924
80Gingivitis (HP:0000230)1.92230478
81Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91728952
82Sandal gap (HP:0001852)1.91637198
83Recurrent fungal infections (HP:0002841)1.91245770
84Granulocytopenia (HP:0001913)1.91233039
85Osteomyelitis (HP:0002754)1.91071133
86Chronic otitis media (HP:0000389)1.90937955
87Amaurosis fugax (HP:0100576)1.89678324
88Leukocytosis (HP:0001974)1.89635469
89Keratoconjunctivitis (HP:0001096)1.88985758
90* Myelodysplasia (HP:0002863)1.88782371
91Hematochezia (HP:0002573)1.88742274
92Trigonocephaly (HP:0000243)1.87738408
93Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.86209365
94Leiomyosarcoma (HP:0100243)1.84790940
95Uterine leiomyosarcoma (HP:0002891)1.84790940
96Increased density of long bones (HP:0006392)1.84560262
97Recurrent gram-negative bacterial infections (HP:0005420)1.83789867
98Subacute progressive viral hepatitis (HP:0006572)1.83261878
99Hepatitis (HP:0012115)1.83173264
100Hyperacusis (HP:0010780)1.82385912
101Vasculitis (HP:0002633)1.82150934
102Abnormality of the 4th metacarpal (HP:0010012)1.81996389
103Severe combined immunodeficiency (HP:0004430)1.81752406
104Heterotopia (HP:0002282)1.81278916
105Birth length less than 3rd percentile (HP:0003561)1.81116644
106Abnormality of oral frenula (HP:0000190)1.81103925
107Truncal obesity (HP:0001956)1.80248030
108Obsessive-compulsive behavior (HP:0000722)1.79969305
109Wide nose (HP:0000445)1.79573658
110Spontaneous hematomas (HP:0007420)1.79533523
111Autoimmune hemolytic anemia (HP:0001890)1.78600183
112Cafe-au-lait spot (HP:0000957)1.78560692
113Broad palm (HP:0001169)1.77874592
114Arterial thrombosis (HP:0004420)1.77647263
115Cutis marmorata (HP:0000965)1.76974641
116Astrocytoma (HP:0009592)1.75195755
117Abnormality of the astrocytes (HP:0100707)1.75195755
118IgA deficiency (HP:0002720)1.74343486
119Supernumerary ribs (HP:0005815)1.74340299
120Mediastinal lymphadenopathy (HP:0100721)1.73993113
121Abnormal foot bone ossification (HP:0010675)1.73076383
122Long clavicles (HP:0000890)1.72899521
123Low anterior hairline (HP:0000294)1.72806764
124Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.72287691
125Selective tooth agenesis (HP:0001592)1.71389878
126Thrombocytosis (HP:0001894)1.70127483
127Dislocated radial head (HP:0003083)1.70030435
128Acute lymphatic leukemia (HP:0006721)1.69011040
129Deep philtrum (HP:0002002)1.68343857
130Protruding tongue (HP:0010808)1.67720316
131Neoplasm of the oral cavity (HP:0100649)1.67509275
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.67211215
133Chronic diarrhea (HP:0002028)1.65688425
134Micronodular cirrhosis (HP:0001413)1.65614276
135Acute hepatic failure (HP:0006554)1.65484355
136Hypoplasia of the maxilla (HP:0000327)1.65040207
137Vertebral arch anomaly (HP:0008438)1.65013643
138Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65012122
139Stomach cancer (HP:0012126)1.64923363
140Abnormality of the radial head (HP:0003995)1.64786245
141Cellulitis (HP:0100658)1.64555853
142Supernumerary bones of the axial skeleton (HP:0009144)1.64450040
143Gastrointestinal carcinoma (HP:0002672)1.64345260
144Malignant gastrointestinal tract tumors (HP:0006749)1.64345260
145Abnormal delayed hypersensitivity skin test (HP:0002963)1.62949227
146Aplasia/Hypoplasia of the sternum (HP:0006714)1.62555930
147Abnormality of the thoracic spine (HP:0100711)1.62384611
148Abnormality of DNA repair (HP:0003254)1.62018347
149Cellular immunodeficiency (HP:0005374)1.61435506
150Aortic aneurysm (HP:0004942)1.60192811
151Glioma (HP:0009733)1.59341492
152Limited elbow extension (HP:0001377)1.58956390
153Rhabdomyosarcoma (HP:0002859)1.58509471
154Persistence of primary teeth (HP:0006335)1.57902363
155Combined immunodeficiency (HP:0005387)1.57550388
156Absent epiphyses (HP:0010577)1.56400688
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.56400688
158Viral hepatitis (HP:0006562)1.56357037
159Biliary tract neoplasm (HP:0100574)1.54802333
160Lip pit (HP:0100267)1.54712729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.73716982
2MAP4K13.19714906
3CDK122.64820786
4BRD42.31442879
5TXK2.12593205
6SRPK12.09943432
7STK102.07721138
8NEK21.99104983
9FGFR31.82894789
10MAP3K101.82879321
11TSSK61.80139014
12JAK31.75892223
13ATR1.75430826
14ITK1.70217821
15EEF2K1.69952335
16PASK1.65536676
17MKNK11.62039780
18PRPF4B1.60042227
19EIF2AK31.59341034
20MAP3K141.54488911
21WEE11.54066696
22RIPK41.53937149
23NUAK11.49173267
24CDK61.48222981
25FES1.45238896
26MARK31.40846552
27SIK21.40083079
28BLK1.38950475
29IRAK11.37146196
30BCR1.35357120
31TYK21.33804206
32AKT31.33548712
33PKN21.33504114
34MKNK21.29246926
35TGFBR11.28938786
36SCYL21.28613742
37STK41.24436925
38IRAK41.24165226
39FGR1.22976877
40FGFR21.22558378
41EPHA31.22060357
42RPS6KB21.20751296
43CCNB11.20564132
44CHEK11.19339272
45BTK1.18898132
46MELK1.18526641
47CDK41.17433494
48CSF1R1.17085396
49SGK31.13013320
50TEC1.11031081
51RPS6KA41.09487618
52SGK21.06877616
53LCK1.06429766
54FLT31.05665371
55JAK11.05489516
56MAP4K21.04705602
57ATM1.03203860
58PIM11.03040023
59DYRK31.02742628
60GRK61.02319941
61PLK31.01658997
62MAP3K81.01594322
63AURKB1.00442806
64LATS10.99828247
65NEK60.99697291
66PDGFRB0.99596434
67CLK10.99111988
68JAK20.98631635
69TRIM280.97365887
70STK38L0.95505188
71TTK0.93733084
72KSR10.92632282
73KIT0.92570163
74WNK10.92517920
75CHUK0.92071799
76ERBB30.89876789
77HCK0.89876097
78SIK30.88869747
79IRAK20.88576245
80TGFBR20.87793694
81ACVR1B0.87218518
82FGFR40.86011013
83ZAP700.85202426
84YES10.84891801
85ALK0.84207331
86CAMK1D0.83839442
87MAP2K30.83834660
88TTN0.82224799
89SYK0.81926053
90* CDK20.80161569
91STK30.79863700
92CHEK20.77110724
93FRK0.76063110
94CDK70.75572310
95VRK10.75259211
96TAOK30.75127410
97BMPR20.74030606
98MAP3K130.70485545
99HIPK20.70340554
100RET0.69658597
101PLK10.69127056
102MAP3K40.68082934
103CSNK1A1L0.67831818
104* CDK10.67185686
105NLK0.65983186
106IKBKE0.65000072
107EIF2AK10.64402428
108PTK60.64227043
109BRSK20.63951678
110CDK90.63303458
111PIK3CG0.63016257
112EPHB10.62707172
113NEK90.62087884
114PIK3CA0.61820866
115MAP3K70.60445681
116TRPM70.59134310
117PLK40.58633350
118CAMK1G0.58394064
119CAMKK20.57825169
120FGFR10.57636144
121PRKDC0.56944897
122LRRK20.56917524
123MAP3K20.56903894
124LYN0.55732279
125CSK0.55535961
126EGFR0.54468007
127MTOR0.53198396
128RPS6KB10.51606795
129MAPK140.51539349
130CSNK1D0.50806455
131TNK20.50045412
132EIF2AK20.49902880
133SGK2230.49663301
134SGK4940.49663301
135MAP3K60.46864784
136MARK20.46418077
137AKT10.46018178
138KSR20.44718892

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.31571873
2DNA replication_Homo sapiens_hsa030302.29338800
3Mismatch repair_Homo sapiens_hsa034302.25277560
4* Spliceosome_Homo sapiens_hsa030402.02541337
5Cell cycle_Homo sapiens_hsa041101.92225759
6Non-homologous end-joining_Homo sapiens_hsa034501.83056488
7mRNA surveillance pathway_Homo sapiens_hsa030151.76043882
8B cell receptor signaling pathway_Homo sapiens_hsa046621.75620903
9RNA transport_Homo sapiens_hsa030131.70248269
10Fanconi anemia pathway_Homo sapiens_hsa034601.69663862
11T cell receptor signaling pathway_Homo sapiens_hsa046601.67113920
12Base excision repair_Homo sapiens_hsa034101.62902291
13Antigen processing and presentation_Homo sapiens_hsa046121.55877634
14Homologous recombination_Homo sapiens_hsa034401.53987636
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52788838
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.52734309
17Herpes simplex infection_Homo sapiens_hsa051681.45090831
18Measles_Homo sapiens_hsa051621.43653942
19RNA degradation_Homo sapiens_hsa030181.34907306
20Chronic myeloid leukemia_Homo sapiens_hsa052201.32417507
21Viral carcinogenesis_Homo sapiens_hsa052031.32063781
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31716733
23Nucleotide excision repair_Homo sapiens_hsa034201.29424620
24Osteoclast differentiation_Homo sapiens_hsa043801.24888669
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24826847
26HTLV-I infection_Homo sapiens_hsa051661.24273603
27Colorectal cancer_Homo sapiens_hsa052101.22991582
28p53 signaling pathway_Homo sapiens_hsa041151.20695165
29MicroRNAs in cancer_Homo sapiens_hsa052061.19430275
30Systemic lupus erythematosus_Homo sapiens_hsa053221.17307324
31Small cell lung cancer_Homo sapiens_hsa052221.15519957
32Epstein-Barr virus infection_Homo sapiens_hsa051691.15453550
33Graft-versus-host disease_Homo sapiens_hsa053321.15350178
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13402031
35Hematopoietic cell lineage_Homo sapiens_hsa046401.13187299
36Hepatitis B_Homo sapiens_hsa051611.12639106
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11798296
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11588723
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.10585434
40Autoimmune thyroid disease_Homo sapiens_hsa053201.10365355
41Choline metabolism in cancer_Homo sapiens_hsa052311.08202891
42Allograft rejection_Homo sapiens_hsa053301.06703461
43Staphylococcus aureus infection_Homo sapiens_hsa051501.06517831
44Pancreatic cancer_Homo sapiens_hsa052121.05204297
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05057728
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05055886
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02776804
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02472157
49Leishmaniasis_Homo sapiens_hsa051400.99505940
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98788776
51Non-small cell lung cancer_Homo sapiens_hsa052230.97967709
52Influenza A_Homo sapiens_hsa051640.96836245
53ErbB signaling pathway_Homo sapiens_hsa040120.96141094
54Viral myocarditis_Homo sapiens_hsa054160.95584356
55Notch signaling pathway_Homo sapiens_hsa043300.95234561
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.93454324
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92912276
58Tuberculosis_Homo sapiens_hsa051520.92626295
59Toxoplasmosis_Homo sapiens_hsa051450.91458398
60Acute myeloid leukemia_Homo sapiens_hsa052210.90721165
61Dorso-ventral axis formation_Homo sapiens_hsa043200.87868987
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87609773
63Endometrial cancer_Homo sapiens_hsa052130.87597593
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86726145
65Platelet activation_Homo sapiens_hsa046110.86154925
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.85077222
67One carbon pool by folate_Homo sapiens_hsa006700.84852111
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.84132685
69FoxO signaling pathway_Homo sapiens_hsa040680.83723927
70Oocyte meiosis_Homo sapiens_hsa041140.83220219
71Basal transcription factors_Homo sapiens_hsa030220.83216840
72Prostate cancer_Homo sapiens_hsa052150.82622295
73mTOR signaling pathway_Homo sapiens_hsa041500.82323796
74Apoptosis_Homo sapiens_hsa042100.81623857
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81100179
76Chemokine signaling pathway_Homo sapiens_hsa040620.80561215
77Shigellosis_Homo sapiens_hsa051310.77543595
78TNF signaling pathway_Homo sapiens_hsa046680.76829249
79Alcoholism_Homo sapiens_hsa050340.76746002
80Proteoglycans in cancer_Homo sapiens_hsa052050.75915181
81Adherens junction_Homo sapiens_hsa045200.74376941
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73673080
83Inositol phosphate metabolism_Homo sapiens_hsa005620.71882836
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70766773
85Type I diabetes mellitus_Homo sapiens_hsa049400.70379825
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69777606
87Pathways in cancer_Homo sapiens_hsa052000.68849035
88HIF-1 signaling pathway_Homo sapiens_hsa040660.68704353
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68261003
90Prolactin signaling pathway_Homo sapiens_hsa049170.68175002
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68038881
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.67451421
93Lysine degradation_Homo sapiens_hsa003100.65600409
94Wnt signaling pathway_Homo sapiens_hsa043100.64682020
95Renal cell carcinoma_Homo sapiens_hsa052110.64088668
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62449834
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61620619
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61513624
99Thyroid cancer_Homo sapiens_hsa052160.60418090
100Basal cell carcinoma_Homo sapiens_hsa052170.59607206
101TGF-beta signaling pathway_Homo sapiens_hsa043500.59075790
102Focal adhesion_Homo sapiens_hsa045100.58488584
103Legionellosis_Homo sapiens_hsa051340.58390053
104Circadian rhythm_Homo sapiens_hsa047100.58376521
105Hippo signaling pathway_Homo sapiens_hsa043900.56478823
106Glioma_Homo sapiens_hsa052140.56407876
107MAPK signaling pathway_Homo sapiens_hsa040100.55058133
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.54909620
109Pyrimidine metabolism_Homo sapiens_hsa002400.53076796
110Hepatitis C_Homo sapiens_hsa051600.52819070
111VEGF signaling pathway_Homo sapiens_hsa043700.51560289
112N-Glycan biosynthesis_Homo sapiens_hsa005100.51353022
113Insulin resistance_Homo sapiens_hsa049310.51162007
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50992534
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50909842
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.50639704
117RNA polymerase_Homo sapiens_hsa030200.50525435
118Asthma_Homo sapiens_hsa053100.48282949
119Other glycan degradation_Homo sapiens_hsa005110.46541442
120Estrogen signaling pathway_Homo sapiens_hsa049150.43718360

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